Journal of Pathology and Translational Medicine

Histopathological Study on Germ Cell Tumors of Hypothalamic Region -A Report of 5 Cases-: Eun Joo Seo, Chong Moo Lee*, Jin Un Song**; J Pathol Transl Med. 1979;13(2):73-76.

1,785 View
10 Download

Abstract: Intracranial tumours histologically identical with seminoma or dysgerminoma of the gonads have been called ectopic pinealoma, germinoma and atypical teratoma. The origin of these tumors is difficult to explain. Primitive germ cells migrate over wide areas of the embryo during early embryonic life. Very occasionally such germ cells have been observed within the developing brain of the embryo. We have experienced 5 cases of intracranial tumors which were confirmed histopathologically as germinoma or teratoma during last 5 years at St. Mary Hospital, Catholic Medical College. The patients were between 12 and 23 years old. All of the cases were males except one case of germinoma. The chief complaints of the male patients were nausea, vomiting and visual disturbances, and histological diagnosis of these cases were 3 germinoma and 1 teratoma. The female patient was 21 years old. The symptoms were those of diabetes inspidus such as polydipaia and polyuria, nausea, vomiting, weight loss and amenorrhea of several months duration. Histologically, it was proved as germinoina.

Histopathological Studies in the Liver Cell and Adrenal Glands in Case of Stress: Chae Hong Suh; J Pathol Transl Med. 1979;13(2):79-82.

1,622 View
10 Download

Abstract: The author has examined the influence of emotional cold stressor upon the liver cells and adrenal glands of rats histopathologically. Consequently the author has drawn the following conclusions : 1. In view of the fact that the characteristic histopathological changes brought about by the non-specific harmful agents mentioned above are common to the liver cells, and that the changes are closely connected with the function of adrenal cortex, these changes should be looked upon as a manifestation of the reaction of organism upon the stress, manely, as a part of General Adaptation Syndrome (Selye). 2. The Stress has a stimulating effect not only on the zona fasciculata, but also on the zona glomerulosa. However, the manifestation of the stimulating effect upon both zones shows discrepancy of time.

A Study on Hemoglobin Electrophoresis in Healthy Adult Persons, Newborns at Birth and Patients with Anemic Diseases: Eun Yup Lee, Soon Ho Kim; J Pathol Transl Med. 1979;13(2):83-92.

2,218 View
10 Download

Abstract: The author investigated hemoglobin types in the peripheral blood obtained from antecubital vein of 90 cases of the healthy adult persons and 18 cases of the patients with anemia, and in the cord blood of 30 cases of the newborns at birth. The patients with anemia consisted of 6 cases of iron deficiency anemia, 6 cases of aplastic anemia and 6 cases of malignant tumor associated with anemia. The hemoglobin concentration estimated by cyanmethemoglobin method and the hemoglobin types estimated by cellulose acetate electrophoresis. The results obtained were summarized as follows : 1. In the healthy adult persons, the mean hemoglobin concentration was 16.0±1.2g/dl in male and 14.4±1.3g/dl in female. The mean percentages of HbA and HbA2 were 96.83±0.58 and 3.12±0.58%, respectively. 2. In the newborns at birth, the mean hemoglobin concentration was 16.7±1.5g/dl and the mean percentages of HbA and HbF were 27.3±5.5% and 72.7±5.5%, respectively. 3. In the patients with aplastic anemia, the mean percentages of HbA, HbA2 and HbF were 93.7±1.7, 2.6±0.4% and 4.2±1.8%, respectively. The mean percentage of HbF in the patients with aplastic anemia was significantly increased than that in the healthy adult persons, while the mean percentages of HbA and HbA2 were significantly decreased. 4. In the patients with iron deficiency anemia, the mean percentages of HbA and HbA2 were 97.6±0.4 and 2.4±0.4%, respectively. The mean percentage of HbA in the patient with iron deficiency anemia was significantly increased than that in the healthy adult persons, while the mean percentage of HbA2 was significantly decreased. 5. In the anemia patients with malignancy, the mean percentages of HbA and HbA2 were 96.8±0.78% and 3.2±0.78%, respectively. And the mean percentages of HbA and HbA2 were not significantly different between the healthy adult persons and the anemia patients with malignancy. According to these results, it may be somewhat helpful to estimate the hemoglobin types in the diagnosis and treatment of aplastic anemia and iron deficiency anemia.

The Serum CAP and LAP Activities in Normal Pregnant Women: Su Ja Chu, Sun Ock Oh, Myong Joon Cho; J Pathol Transl Med. 1979;13(2):95-101.

1,596 View
10 Download

Abstract: The values of the serum cystine aminopeptidase and leucine aminopeptidase activities in clinically healthy pregnant women have been studied using Iatron Kit according to months of gestation periods. 1. The serum cystine aminopeptidase and leucine aminopeptidase activities in extensively normal women (control group) were 13.75±2.67 munit/ml. and 170.33±33.39 G-R unit/ml. respectively, and fail to show remarkable changes in early pregnancy (up to 5 months of periods). 2. The mean CAP and LAP activities in normal pregnant women showed progressively increasing tendency by months of gestation with a mean of 175±64.30 munit/ml. and 517.2±165.47 G-R unit/ml. at term. About 15 fold increased value in CAP and 3 to 4 fold increased value in LAP than those of early pregnancy and control group were noted at term. 3. A positive correlation (P<0,005) was found between cystine aminopeptidase and leucine aminopeptidase activities in pregnant women. It is, therefore, suggested that the comparative evaluation of cystine aminopeptidase and leucine aminopeptidase activities, relatively simple and easy to perform, could be used as a parameter in judging the functional state of the placenta during late pregnancy.

A Histopathological Study of Brenner Tumor of Ovary -A report of 3 cases-: Hea Soo Koo, Moon Hyang Park, Hyo Sook Park; J Pathol Transl Med. 1979;13(2):103-109.

1,718 View
10 Download

Abstract: Brenner tumor is a rare neoplasm of the ovary and there is general agreement that he tumor is derived from surface (coelomic) epithelium. We have experienced three cases of Brenner tumor in Pathology department of National Medical Center during 4 years and 6 months from Jan. 1975 to June 1979, which comprised 2.1% of 142 all benign ovarian tumors. The size of tumor was variable from microscopic to 15cm. in maximal diameter. Two of them were bilateral and another one had marked calcification in the stroma. One of the three cases was accompanied by mucinous cystadenoma. None of them showed proliferating or malignant pattern.

A Case of Sebaceous Epithelioma: Song Hoi Park, Je Geun Chi, Yong Il Kim; J Pathol Transl Med. 1979;13(2):111-115.

2,032 View
10 Download

Abstract: The sebaceous epithelioma is a rare variety of skin tumor, the histogenesis of which is not clearly elucidated. Their clinical character, localization and age incidence are very similar to basal cell epithelioma, but they have small number of mature sebaceous cells as tumor element, The main pathologic finding is proliferation of basaloid germinative cells of the sebaceous glands. We experienced a case of a recurrent sebaceous epithelioma of the right parotid area in a 37-year-old woman. She had her tumor removed at the same site one year previously. The clinical impression was neoplasm of salivary glands. The tumor was located just beneath the focally ulcerated skin, and was partly encapsulated and lobulated and measured 4×2.5×2.5cm. Cut surface was homogeneously yellowish white, showing lobule formation by fibrous septa of varying thickness. Areas of hemorrhage and cystic change were seen. Microscopically there were poorly defined masses of cells of basaloid shape. There were many cystic spaces, containing amorphous hyaline-like material. This material appeared foamy and in glaces vacuolated. The tumor masses consisted of two cell types, one was similar to that seen in the basal cell epithelioma and the other was sebaceous in nature. Germinative cells were predominant throughout and invaded the fibrous septa. Mild inflammatory infiltrates were present in areas. The overlying epidermis was relatively well maintained except for focal ulceration.

A Case of Anorectal Malignant Melanoma: Kyung Ho Shin, Jae Sik Kim, Jyung Myung Kim, Eun Sook Chang*; J Pathol Transl Med. 1979;13(2):117-121.

1,682 View
10 Download

Abstract: The malignant melanoma of the anorectum is relatively rare and is highly virulent. There are only two cases reported in Korea, as far as our knowledge is concerned. In March 1979, we experienced a case of anorectal malignant melanoma, in a 50 years old woman. A case presentation with histopathological findings and a brief review of the literature were done.

Epidermoid Carcinoma arising in a Benign Cystic Teratoma of the Ovary -A Case Report-: Sang Sook Lee, Eun Sook Chang; J Pathol Transl Med. 1979;13(2):123-128.

1,867 View
10 Download

Abstract: Although dermoid cysts of cystic teratomas of the ovary are almost always benign tumors, the rare development of cancer deserves emphasis. All too often the change that suggest this complication are overlooked at the time of operation, and the correct diagnosis is not made until the opportunity for primary treatment has passed. We have recently experienced a case of epidermoid carcinoma, arising from the benign cystic teratoma of the ovary in a 52-year-old Korean woman, which herein reported and the literatures.

Two Cases of Nacardia asteroides Abscess: Yong Mo Ahn, Yunsop Chong, Samuel Y. Lee, Byung Soo Kim*, Hee Soo Rhee**; J Pathol Transl Med. 1979;13(2):129-134.

1,721 View
10 Download

Abstract: Nocardia is a gram-positive, acid-fast bacillus causing various clinical infections mostly in compromised hosts. Two cultures of N. asteroides were obtained ; one from a back trunk abscess of a 37-year-old male with Hodgkin's disease and the other from a buttock abscess of a 12-year-old girl. The former case had a history of therapy with cytotoxic drugs and steroides and the latter with intramuscular injections for her synovitis. These were thought to be the possible predisposing factors of the infections. In both cases, the direct smear of pus revealed the characteristic morphology of Nocardia and the culture yielded, N. asteroides which were identified on the basis of cultural and biochemical characteristics.

Primary Carcinoma of the Gallbladder -Report of 37 Cases-: Sang Sook Lee, Eun Sook Chang, Chai Hong Chung; J Pathol Transl Med. 1979;13(2):137-145.

1,719 View
10 Download

Abstract: Carcinoma of the gallbladder is an infrequent tumor of the gastrointestinal tract. It was first described by Stoll in 1771 and it has since been recognized as a highly malignant neoplasm of older females occurring more frequently in patients with preexisting cholelithiasis. Thirty-seven cases of carcinoma of the gallbladder were reviewed and the following results were obtained. 1. The age and sex distributions were summarized in Table 1. Of the total 37 cases, the disease was most common in older females(mean age, 57 years). 2. The incidence was 4.3% of total 863 biliary tract operations during the same period. 3. Gallstones with or without stones in the common bile duct were present in 8 patients. One patient had common bile stones only. Three patients had Clonorchis sinensis. 4. The incidence of cholelithiasis accompanying carcinoma was 2.8% of total 275 cases of Cholecystectomy for Cholelithiasis during the same period. 5. The most common symptoms and signs were RUQ palpable mass, jaundice and weight loss in order. 6. The carcinoma of the gall bladder was diagnosed in only 8 cases. 7. Histologic examination of the tumors revealed adenocarcinoma in 27 of the patients, (papillary carcinoma in 10) anaplastic carcinoma in 4, squamous cell carcinoma in 4, and adenosquamous carcinoma in 2. 8. Thirty-three patients had a preexisting clinical history of recurrent RUQ pain, suggestive of cholelithiasis for a median duration of about 2 years. Twenty-five patients had a histologic evidence of chronic cholecystitis. 9. Metastatic sites were the liver, closely followed by regional Iymph node, omentum, common bile duct, ovary, stomach, ileum, and transverse colon. 10. Therefore prophylactive cholecystectomy is recommended in the young Patients suffering from cholelithiasis.

A Case Report of Three Malignant Endometrioid Tumors of Ovary: Bom Woo Yeom, Moon Ja Kang, In Sun Kim, Seung Yong Paik; J Pathol Transl Med. 1979;13(2):147-153.

1,473 View
11 Download

Abstract: The endometrioid carcinoma is a primary neoplasm of the ovary which on light and electron microscopy, closely resembles adenocarcinoma of the uterine endometrium. It is one of the common ovarian carcinoma, but frequently diagnosed as unclassified adenocarcinoma or other types of adenocarcinoma due to histological variabilties of the tumor. The mesodermal mixed tumor of the ovary is a combined epithelial and mesenchymal neoplasm containing heterologous elements. This tumor is closely related with carcinosarcomas having homologous mesenchymal elements but differential diagnosis must be done due to better prognosis in carcinosarcoma. Histogenesis of endometrioid carcinoma and mesodermal mixed tumor are controversial but at present, most pathologists believe that these tumors are considered to originate from ovarian endometriosis, Mullerian or surface epithelium of the ovary. According to WHO classification, these tumors are categorized in malignant endometrioid tumors of the ovary. We report two cases of endometrioid carcinoma and one case of mesodermal mixed tumor of the ovary.

Angioimmunoblastic Lymphadenopathy with Dysproteinemia -Report of a Case-: Nam Hee Won, In Sun Kim, Seung Yong Paik; J Pathol Transl Med. 1979;13(2):155-160.

1,527 View
10 Download

Abstract: A new clinico-pathologic disease of Iymphoid system has been reported as immunoblastic Iymphadenopathy by Lukes and Tindle and as angioimmunoblastic Iymphadenopathy with dysproteinemia (AILD) by Frizzera et. at. Clinically it occurs most commonly in elder person is characterized by acute onset of constitutional symptoms, generalized Iymphadenopathy, hepatosplenomegaly and immunologic abnormalitis such as consistent polyclonal gammopathy and often hemolytic anemia. Histologically it has a diagnostic triad ; 1) loss of nodal architecture and pleomorphic infiltration of immunoblasts, plasmacytoid immunoblasts, plasma cells and Iymphocytes, 2) prominent proliferation of arborizing small vessels and 3) deposit of PAS-positive amorphous material in the interstitium. We report here a case of angioimmunoblastic Iymphadenopathy with dysproteinemia of a 64 year old male patient and review the literature.

Chordoma Presumed from Aspirated Materials -A Case Report-: Jae Sik Kim; J Pathol Transl Med. 1979;13(2):163-167.

1,842 View
10 Download

Abstract: Chordoma was suspected with the aspirated materials from 18 year-old woman high school girl complaining of severe pain on sacrococcygeal region and legs as well as walking disturbance over a year. The first tiny biopsy piece of sacrococcygeal region revealed only nonspecific chronic inflammation. No response to antibiotic and conservative therapy. An aspiration cytology and cell block preparation were done. The former revealed very characteristic vacuolated physaliferous cells in considerable numbers and the later showed same cells as well as foci of cells mimicking osteogenic sarcoma. Another biopsy obtained at the other hospital in Seoul revealed the lobulated groups of similar vacuolated cells mentioned as above were separated by fibrous tissue and foci of the aggregation of aggressive cells.

One Drop Method of MHA-TP: Kyung Sun Kim, Jae Sik Kim; J Pathol Transl Med. 1979;13(2):169-174.

1,396 View
10 Download

Abstract: One drop method of micro-TPHA(MHA-TP) using one drop of TP sensitized sheep red blood cells instead of three drops was evaluated for screening and the specific serological test for syphilis. Macro-tray method revealed almost same patterns of reaction in both two drops and 1 drop. In the later the ring of red cell pack is more dense and sharp than 2 drops method, in negative. The micro-tray method revealed also clear cut patterns of reaction in positive and negative results. The test cost may be reduced from 1/2 to 1/3 of original test cost by one drop method. The micro-tray method is prefered to recommend on account of the conveniency. One drop method appeared to be both the economical screening and specific confirmation for syphilis when one drop method is applied together with VDRL and RPR test.

Previous issues