Journal of Pathology and Translational Medicine

Volume 51(5); September 2017

Review

White Matter Injury of Prematurity: Its Mechanisms and Clinical Features: Young Ah Lee; J Pathol Transl Med. 2017;51(5):449-455. Published online August 11, 2017; DOI: https://doi.org/10.4132/jptm.2017.07.25

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A developing central nervous system is vulnerable to various insults such as infection and ischemia. While increased understanding of the dynamic nature of brain development allows a deeper insight into the pathophysiology of perinatal brain injury, the precise nature of specific fetal and neonatal brain injuries and their short- and long-term clinical consequences need special attention and further elucidation. The current review will describe the pathophysiological aspects and clinical significance of white matter injury of prematurity, a main form of perinatal brain injury in premature newborns, with a particular emphasis on its potential antenatal components.

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Adrien Dufour, Ariane Heydari Olya, Sophie Foulon, Clémence Réda, Amazigh Mokhtari, Valérie Faivre, Jennifer Hua, Cindy Bokobza, Andrew D. Griffiths, Philippe Nghe, Pierre Gressens, Andrée Delahaye-Duriez, Juliette Van Steenwinckel
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FGF21 Alleviates Hypoxic-Ischemic White Matter Injury in Neonatal Mice by Mediating Inflammation and Oxidative Stress Through PPAR-γ Signaling Pathway
Mingchu Fang, Liying Lu, Jia Lou, Jiahao Ou, Qianqian Yu, Xiaoyue Tao, Jianghu Zhu, Zhenlang Lin
Molecular Neurobiology.2025; 62(4): 4743. CrossRef
Minimum effective dose of clemastine in a mouse model of preterm white matter injury
Elizabeth P. Odell, Nora Jabassini, Björn Schniedewind, Sarah E. Pease-Raissi, Adam Frymoyer, Uwe Christians, Ari J. Green, Jonah R. Chan, Bridget E. L. Ostrem
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The Neuroprotective Mechanisms of PPAR‐γ: Inhibition of Microglia‐Mediated Neuroinflammation and Oxidative Stress in a Neonatal Mouse Model of Hypoxic‐Ischemic White Matter Injury
Mingchu Fang, Qianqian Yu, Jiahao Ou, Jia Lou, Jianghu Zhu, Zhenlang Lin
CNS Neuroscience & Therapeutics.2024;[Epub] CrossRef
Neurodevelopmental outcome in preterm neonates
Ilija Palić, Ružica Kravljanac
Medicinski podmladak.2024; 75(3): 43. CrossRef
Parsing brain-behavior heterogeneity in very preterm born children using integrated similarity networks
Laila Hadaya, Konstantina Dimitrakopoulou, Lucy D. Vanes, Dana Kanel, Sunniva Fenn-Moltu, Oliver Gale-Grant, Serena J. Counsell, A. David Edwards, Mansoor Saqi, Dafnis Batalle, Chiara Nosarti
Translational Psychiatry.2023;[Epub] CrossRef
Kaempferol improves periventricular white matter injury in premature infants by inhibiting microglial activation
Qiuling Zhuo, Binsha Fu, Liangsun Shi
Materials Express.2023; 13(5): 916. CrossRef
The impact of neonatal morbidities on child growth and developmental outcomes in very low birth weight infants: a nationwide cohort study
Jung Ho Han, So Jin Yoon, Joo Hee Lim, Jeong Eun Shin, Ho Seon Eun, Min Soo Park, Kook In Park, Soon Min Lee
European Journal of Pediatrics.2022; 181(1): 197. CrossRef
Global and Regional White Matter Fractional Anisotropy in Children with Chronic Kidney Disease
Ellen van der Plas, Matthew A. Solomon, Lauren Hopkins, Timothy Koscik, Jordan Schultz, Patrick D. Brophy, Peggy C. Nopoulos, Lyndsay A. Harshman
The Journal of Pediatrics.2022; 242: 166. CrossRef
A Case of Prenatally Diagnosed Congenital Adrenal Hyperplasia With Brain Morphometric Differences
Vidya Rajagopalan, Lloyd Nate Overholtzer, William S. Kim, Jessica L. Wisnowski, David A. Miller, Mitchell E. Geffner, Mimi S. Kim
Journal of Investigative Medicine High Impact Case Reports.2022;[Epub] CrossRef
Role of Vitamin E in Neonatal Neuroprotection: A Comprehensive Narrative Review
Sarah Kolnik, Thomas Wood
Life.2022; 12(7): 1083. CrossRef
Sirt2 promotes white matter oligodendrogenesis during development and in models of neonatal hypoxia
Beata Jablonska, Katrina L. Adams, Panagiotis Kratimenos, Zhen Li, Emma Strickland, Tarik F. Haydar, Katharina Kusch, Klaus-Armin Nave, Vittorio Gallo
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PGC-1α activity and mitochondrial dysfunction in preterm infants
Atefeh Mohammadi, Randa Higazy, Estelle B. Gauda
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Intranasal mesenchymal stem cell therapy to boost myelination after encephalopathy of prematurity
Josine E. G. Vaes, Caren M. van Kammen, Chloe Trayford, Annette van der Toorn, Torben Ruhwedel, Manon J. N. L. Benders, Rick M. Dijkhuizen, Wiebke Möbius, Sabine H. van Rijt, Cora H. Nijboer
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The impact of trophic and immunomodulatory factors on oligodendrocyte maturation: Potential treatments for encephalopathy of prematurity
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Glia.2021; 69(6): 1311. CrossRef
Pioglitazone Ameliorates Lipopolysaccharide-Induced Behavioral Impairment, Brain Inflammation, White Matter Injury and Mitochondrial Dysfunction in Neonatal Rats
Jiann-Horng Yeh, Kuo-Ching Wang, Asuka Kaizaki, Jonathan W. Lee, Han-Chi Wei, Michelle A. Tucci, Norma B. Ojeda, Lir-Wan Fan, Lu-Tai Tien
International Journal of Molecular Sciences.2021; 22(12): 6306. CrossRef
Dissecting the Roles of LncRNAs in the Development of Periventricular White Matter Damage
Xinyu Wang, Heng Liu, Xiaoli Liao, Lixing Qiao, Lihua Zhu, Shun Wu, Yan Zhou, Yi Zhang, Bangbang Li, Lili Lin, Jingjing Ma, Qianying Gu, Jiaping Shu
Frontiers in Genetics.2021;[Epub] CrossRef
Targeting Microglial Disturbances to Protect the Brain From Neurodevelopmental Disorders Associated With Prematurity
Andrée Delahaye-Duriez, Adrien Dufour, Cindy Bokobza, Pierre Gressens, Juliette Van Steenwinckel
Journal of Neuropathology & Experimental Neurology.2021; 80(7): 634. CrossRef
Circular RNA expression alteration in whole blood of premature infants with periventricular white matter damage
Lixing Qiao, Sisi Mo, Yan Zhou, Yi Zhang, Bangbang Li, Shun Wu, Lili Lin, Lihua Zhu, Ruibin Zhao
Genomics.2020; 112(4): 2875. CrossRef
Feed-forward neural networks using cerebral MR spectroscopy and DTI might predict neurodevelopmental outcome in preterm neonates
T. Janjic, S. Pereverzyev, M. Hammerl, V. Neubauer, H. Lerchner, V. Wallner, R. Steiger, U. Kiechl-Kohlendorfer, M. Zimmermann, A. Buchheim, A. E. Grams, E. R. Gizewski
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White Matter Injury in Early Brain Injury after Subarachnoid Hemorrhage
Jinwei Pang, Jianhua Peng, Ping Yang, Li Kuai, Ligang Chen, John H. Zhang, Yong Jiang
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The Potential of Stem Cell Therapy to Repair White Matter Injury in Preterm Infants: Lessons Learned From Experimental Models
Josine E. G. Vaes, Marit A. Vink, Caroline G. M. de Theije, Freek E. Hoebeek, Manon J. N. L. Benders, Cora H. A. Nijboer
Frontiers in Physiology.2019;[Epub] CrossRef
Abilitation of Infants with Combined Perinatal Pathology: Capabilities of Approaches and Methods Personalization
Аlexander A. Baranov, Leyla S. Namazova-Baranova, Irina A. Belyaeva, Еlena V. Аntonova, Еlena A. Vishneva, Еlena P. Bombardirova, Vladimir I. Smirnov, Аlexsei I. Molodchenkov, Мariay О. Zubrikhina
Current Pediatrics.2019; 18(2): 91. CrossRef
Advanced nanotherapies to promote neuroregeneration in the injured newborn brain
Olatz Arteaga Cabeza, Alkisti Mikrogeorgiou, Sujatha Kannan, Donna M. Ferriero
Advanced Drug Delivery Reviews.2019; 148: 19. CrossRef
Rapid Postnatal Adaptation of Neurodevelopment in Pigs Born Late Preterm
Charlotte Holme Nielsen, Anne Bladt Brandt, Thomas Thymann, Karina Obelitz-Ryom, Pingping Jiang, Charlotte Vanden Hole, Chris van Ginneken, Stanislava Pankratova, Per Torp Sangild
Developmental Neuroscience.2018; 40(5-6): 586. CrossRef

Original Articles

The Potential Roles of MELF-Pattern, Microvessel Density, and VEGF Expression in Survival of Patients with Endometrioid Endometrial Carcinoma: A Morphometrical and Immunohistochemical Analysis of 100 Cases: Dmitry Aleksandrovich Zinovkin, Md Zahidul Islam Pranjol, Daniil Rudolfovich Petrenyov, Eldar Arkadievich Nadyrov, Oleg Gennadievich Savchenko; J Pathol Transl Med. 2017;51(5):456-462. Published online September 14, 2017; DOI: https://doi.org/10.4132/jptm.2017.07.19

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Abstract PDF

Background
In this study, we hypothesized that microcystic, elongated, fragmented (MELF)-pattern, vascular endothelial growth factor (VEGF) expression by cancer cells and microvessel density of cancer stroma may be associated with progression of endometrioid adenocarcinoma. Methods: The study used data from the Belarus Cancer Registry and archival histological material of 100 patients with retrospectively known good (survival) and poor (disease progression and death) outcomes. All cases were immunohistochemically stained for CD34 and VEGF. Two independent samples were compared for the characteristics of signs, and obtained results were analyzed by receiver operating characteristic analysis, Mann-Whitney U test, χ² test (Yates correction), and Mantel-Cox test. Multivariate Cox hazard analysis and Spearman correlation test were used. A p-value of less than .05 was considered statistically significant. Results: The observed survival rate of patients with endometrioid adenocarcinoma was significantly lower (p = .002) in MELF-pattern positive patients when compared with MELF-pattern negative patients. The overall survival rate of patients whose tumors had more than 114 vessels/mm² of tissue was significantly low (p < .001). Interestingly, a similar observation was found in patients with increased vessel area, evidenced by VEGF expression in the glandular tumor component. Conclusions: Our study suggests, for the first time, that these criteria may be used as risk factors of endometrioid adenocarcinoma progression during 5 years after radical surgical treatment. However, a large independent cohort of samples should be considered in the future to validate our findings.

Citations

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Molecular Classification of Endometrial Endometrioid Carcinoma With Microcystic Elongated and Fragmented Pattern
Baohui Ju, Jianghua Wu, Lin Sun, Chunrui Yang, Hu Yu, Quan Hao, Jianmei Wang, Huiying Zhang
International Journal of Gynecological Pathology.2024; 43(3): 233. CrossRef
Association of Local and Distant Organ Metastases With MELF Pattern in Endometrial Cancer
Varol Gülseren, Ertuğrul Şen, Mehmet Dolanbay, Fulya Çağli, Nahit Topaloğlu, Figen Öztürk, Bülent Özçelik, Serdar Serin, Kemal Güngördük
International Journal of Gynecological Pathology.2024;[Epub] CrossRef
The vasculogenic mimicry, CD146 + and CD105 + microvessel density in the prognosis of endometrioid endometrial adenocarcinoma: a single-centre immunohistochemical study
Dmitry A. Zinovkin, Hongbo Wang, Zhicheng Yu, Qian Zhang, Yang Zhang, Sitian Wei, Ting Zhou, Qi Zhang, Jun Zhang, Eldar A. Nadyrov, Abdullah Farooq, Yulia Lyzikova, Ilya V. Vejalkin, Irina I. Slepokurova, Md Zahidul Islam Pranjol
Biomarkers.2024; 29(7): 459. CrossRef
Dynamic contrast-enhanced MR imaging of uterine endometrial carcinoma with/without squamous differentiation
Mayumi Takeuchi, Kenji Matsuzaki, Yoshimi Bando, Masafumi Harada
Abdominal Radiology.2023; 48(8): 2494. CrossRef
Role of adipocytokines in endometrial cancer progression
Ran Li, Fang Dong, Ling Zhang, Xiuqin Ni, Guozhi Lin
Frontiers in Pharmacology.2022;[Epub] CrossRef
Endometrial carcinoma: use of tracer kinetic modeling of dynamic contrast-enhanced MRI for preoperative risk assessment
Zhijun Ye, Gang Ning, Xuesheng Li, Tong San Koh, Huizhu Chen, Wanjing Bai, Haibo Qu
Cancer Imaging.2022;[Epub] CrossRef
Microcystic elongated and fragmented (MELF) pattern of invasion: Molecular features and prognostic significance in the PORTEC-1 and -2 trials
A.S.V.M. van den Heerik, K.T.S. Aiyer, E. Stelloo, I.M. Jürgenliemk-Schulz, L.C.H.W. Lutgens, J.J. Jobsen, J.W.M. Mens, E.M. van der Steen-Banasik, C.L. Creutzberg, V.T.H.B.M. Smit, N. Horeweg, T. Bosse
Gynecologic Oncology.2022; 166(3): 530. CrossRef
Pathological features, immunoprofile and mismatch repair protein expression status in uterine endometrioid carcinoma: focus on MELF pattern of myoinvasion
Angela Santoro, Giuseppe Angelico, Frediano Inzani, Saveria Spadola, Damiano Arciuolo, Michele Valente, Teresa Musarra, Giovanni Capelli, Francesco Fanfani, Valerio Gallotta, Giovanni Scambia, Gian Franco Zannoni
European Journal of Surgical Oncology.2021; 47(2): 338. CrossRef
Prognostic impact of tumor budding in endometrial carcinoma within distinct molecular subgroups
Tilman T. Rau, Eva Bettschen, Carol Büchi, Lucine Christe, Amanda Rohner, Michael D. Müller, Joseph W. Carlson, Sara Imboden, Inti Zlobec
Modern Pathology.2021; 34(1): 222. CrossRef
Sentinel Nodal Metastasis Detection in Endometrial Carcinoma With Microcystic, Elongated, and Fragmented (MELF) Pattern by Cytokeratin Immunostaining
Kimmie M Rabe, Molly E Klein, Sayak Ghatak, Irina Stout, Alexandra Schefter, Britt K Erickson, Mahmoud A Khalifa
American Journal of Clinical Pathology.2021; 156(5): 846. CrossRef
Patterns of Myometrial Invasion in Endometrial Adenocarcinoma with Emphasizing on Microcystic, Elongated and Fragmented (MELF) Glands Pattern: A Narrative Review of the Literature
Svetlana Mateva, Margarita Nikolova, Angel Yordanov
Diagnostics.2021; 11(9): 1707. CrossRef
Increase in FoxP3, CD56 immune cells and decrease in glands PGRMC1 expression in the endometrium are associated with recurrent miscarriages
Yulia Anatolievna Lyzikova, Dmitry Aleksandrovich Zinovkin, Md Zahidul Islam Pranjol
European Journal of Obstetrics & Gynecology and Reproductive Biology.2020; 245: 121. CrossRef
Clinicopathologic Association and Prognostic Value of MELF Pattern in Invasive Endocervical Adenocarcinoma (ECA) as Classified by IECC
Sheila E. Segura, Lien Hoang, Monica Boros, Cristina Terinte, Anna Pesci, Sarit Aviel-Ronen, Takako Kiyokawa, Isabel Alvarado-Cabrero, Esther Oliva, Kay J. Park, Robert A. Soslow, Simona Stolnicu
International Journal of Gynecological Pathology.2020; 39(5): 436. CrossRef
Usual-Type Endocervical Adenocarcinoma with a Microcystic, Elongated, and Fragmented Pattern of Stromal Invasion: A Case Report with Emphasis on Ki-67 Immunostaining and Targeted Sequencing Results
Sangjoon Choi, Soohyun Hwang, Sung-Im Do, Hyun-Soo Kim
Case Reports in Oncology.2020; 13(3): 1421. CrossRef
High Expression of Galectin-1, VEGF and Increased Microvessel Density Are Associated with MELF Pattern in Stage I-III Endometrioid Endometrial Adenocarcinoma
Dmitry Aleksandrovich Zinovkin, Sergey Leonidovich Achinovich, Mikhail Grigoryevich Zubritskiy, Jacqueline Linda Whatmore, Md Zahidul Islam Pranjol
Journal of Pathology and Translational Medicine.2019; 53(5): 280. CrossRef
The Roles of Melf Patterns, the Depth of Invasion and Number of Tumor Emboli as the Predictive Factors of the Survival Rate Among Patients with Endometrioid Adenocarcinoma of the Corpus Uterus
D. A. Zinovkin
Health and Ecology Issues.2019; (1): 49. CrossRef
Non-endometrioid and high-grade endometrioid endometrial cancers show DNA fragmentation factor 40 (DFF40) and B-cell lymphoma 2 protein (BCL2) underexpression, which predicts disease-free and overall survival, but not DNA fragmentation factor 45 (DFF45) u
Tomasz Banas, Kazimierz Pitynski, Krzysztof Okon, Aleksandra Winiarska
BMC Cancer.2018;[Epub] CrossRef
Tumor-Associated T-Lymphocytes and Macrophages are Decreased in Endometrioid Endometrial Carcinoma with MELF-Pattern Stromal Changes
Dmitry Aleksandrovich Zinovkin, Md Zahidul Islam Pranjol, Il’ya Andreevich Bilsky, Valeriya Alexandrovna Zmushko
Cancer Microenvironment.2018; 11(2-3): 107. CrossRef
MELF pattern of myometrial invasion and role in possible endometrial cancer diagnostic pathway: A systematic review of the literature
Anastasia Prodromidou, George Vorgias, Konstantinos Bakogiannis, Nikolaos Kalinoglou, Christos Iavazzo
European Journal of Obstetrics & Gynecology and Reproductive Biology.2018; 230: 147. CrossRef
CORRELATIVE INTERRELATIONS OF THE TUMOR MICROENVIRONMENT AND RELATIVE RISK OF UNFAVOURABLE OUTCOME OF ENDOMETRIOID ADENOCARCINOMA OF THE CORPUS UTERI
D. A. Zinovkin
Health and Ecology Issues.2018; (3): 48. CrossRef

The Intraoperative Immunohistochemical Staining of CD56 and CK19 Improves Surgical Decision for Thyroid Follicular Lesions: Ju Yeon Pyo, Sung-eun Choi, Eunah Shin, JaSeung Koo, SoonWon Hong; J Pathol Transl Med. 2017;51(5):463-470. Published online August 2, 2017; DOI: https://doi.org/10.4132/jptm.2017.05.25

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152 Download
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Abstract PDF

Background
When differential diagnosis is difficult in thyroid follicular lesions with overlapping histological features, the immunohistochemical staining can help confirm the diagnosis. We aimed to evaluate the effectiveness of rapid immunohistochemical stains of CD56 and cytokeratin 19 on frozen sections of thyroid follicular lesion and explore the possible gains and limitations of the practice. Methods: Eighty-six nodules of 79 patients whose intraoperative frozen sections were selected as the control group, and 53 nodules of 48 patients whose intraoperative frozen sections were subject to rapid immunohistochemistry were selected as the study group. Results: Five nodules (6%) in the control group were diagnosed as follicular neoplasm and six nodules (7%) were deferred. In the study group, six nodules (11%) were follicular neoplasm and none were deferred. Three nodules (4%) in the control group showed diagnostic discrepancy between the frozen and permanent diagnoses, but none in the study group. The average turnaround time for the frozen diagnosis of the control group was 24 minutes, whereas it was 54 minutes for the study group. Conclusions: Intraoperative rapid immunohistochemical stains significantly decreased the diagnostic discrepancy in this study. Considering the adverse effects of indefinite frozen diagnosis or discrepancy with permanent diagnoses, the intraoperative rapid immunohistochemical stain can help to accurately diagnose and hence provide guidance to surgical treatment.

Citations

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High-Contrast Facile Imaging with Target-Directing Fluorescent Molecular Rotors, the N3-Modified Thioflavin T Derivatives
Yuka Kataoka, Hiroto Fujita, Arina Afanaseva, Chioko Nagao, Kenji Mizuguchi, Yuuya Kasahara, Satoshi Obika, Masayasu Kuwahara
Biochemistry.2019; 58(6): 493. CrossRef
The diagnostic value of TROP-2, SLP-2 and CD56 expression in papillary thyroid carcinoma
Xueyang Yang, Yifang Hu, He Shi, Chengzhou Zhang, Zhixiao Wang, Xiaoyun Liu, Huanhuan Chen, Lijuan Zhang, Dai Cui
European Archives of Oto-Rhino-Laryngology.2018; 275(8): 2127. CrossRef

Diverse Immunoprofile of Ductal Adenocarcinoma of the Prostate with an Emphasis on the Prognostic Factors: Se Un Jeong, Anuja Kashikar Kekatpure, Ja-Min Park, Minkyu Han, Hee Sang Hwang, Hui Jeong Jeong, Heounjeong Go, Yong Mee Cho; J Pathol Transl Med. 2017;51(5):471-481. Published online August 9, 2017; DOI: https://doi.org/10.4132/jptm.2017.06.02

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205 Download
14 Web of Science
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Abstract PDF

Background
Ductal adenocarcinoma (DAC) of the prostate is an uncommon histologic subtype whose prognostic factors and immunoprofile have not been fully defined. Methods: To define its prognostic factors and immunoprofile, the clinicopathological features, including biochemical recurrence (BCR), of 61 cases of DAC were analyzed. Immunohistochemistry was performed on tissue microarray constructs to assess the expression of prostate cancer-related and mammalian target of rapamycin (mTOR) signaling-related proteins. Results: During the median follow-up period of 19.3 months, BCR occurred in 26 cases (42.6%). DAC demonstrated a wide expression range of prostate cancer-related proteins, including nine cases (14.8%) that were totally negative for pan-cytokeratin (PanCK) immunostaining. The mTOR signaling-related proteins also showed diverse expression. On univariate analysis, BCR was associated with high preoperative serum levels of prostate-specific antigen (PSA), large tumor volume, predominant ductal component, high Gleason score (GS), comedo-necrosis, high tumor stage (pT), lymphovascular invasion, and positive surgical margin. High expressions of phospho-mTOR (p-mTOR) as well as low expressions of PSA, phospho-S6 ribosomal protein (pS6) and PanCK were associated with BCR. On multivariable analysis, GS, pT, and immunohistochemical expressions of PanCK and p-mTOR remained independent prognostic factors for BCR. Conclusions: These results suggest GS, pT, and immunohistochemical expressions of PanCK and p-mTOR as independent prognostic factors for BCR in DAC. Since DAC showed diverse expression of prostate cancer–related proteins, this should be recognized in interpreting the immunoprofile of DAC. The diverse expression of mTOR-related proteins implicates their potential utility as predictive markers for mTOR targeted therapy.

Citations

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Intermediate risk prostate tumors contain lethal subtypes
William L. Harryman, James P. Hinton, Rafael Sainz, Jaime M. C. Gard, John M. Ryniawec, Gregory C. Rogers, Noel A. Warfel, Beatrice S. Knudsen, Raymond B. Nagle, Juan J. Chipollini, Benjamin R. Lee, Belinda L. Sun, Anne E. Cress
Frontiers in Urology.2025;[Epub] CrossRef
High GLUT1 membrane expression and low PSMA membrane expression in Ductal Adenocarcinoma and Intraductal Carcinoma of the prostate
Xingming Wang, Li Zhou, Lin Qi, Ye Zhang, Hongling Yin, Yu Gan, Xiaomei Gao, Yi Cai
Prostate Cancer and Prostatic Diseases.2024; 27(4): 720. CrossRef
Association of Lymphovascular Invasion with Biochemical Recurrence and Adverse Pathological Characteristics of Prostate Cancer: A Systematic Review and Meta-analysis
Jakub Karwacki, Marcel Stodolak, Andrzej Dłubak, Łukasz Nowak, Adam Gurwin, Kamil Kowalczyk, Paweł Kiełb, Nazar Holdun, Wojciech Szlasa, Wojciech Krajewski, Agnieszka Hałoń, Anna Karwacka, Tomasz Szydełko, Bartosz Małkiewicz
European Urology Open Science.2024; 69: 112. CrossRef
Impact of Epithelial Histological Types, Subtypes, and Growth Patterns on Oncological Outcomes for Patients with Nonmetastatic Prostate Cancer Treated with Curative Intent: A Systematic Review
Giancarlo Marra, Geert J.L.H. van Leenders, Fabio Zattoni, Claudia Kesch, Pawel Rajwa, Philip Cornford, Theodorus van der Kwast, Roderick C.N. van den Bergh, Erik Briers, Thomas Van den Broeck, Gert De Meerleer, Maria De Santis, Daniel Eberli, Andrea Faro
European Urology.2023; 84(1): 65. CrossRef
Impact of comedonecrosis on prostate cancer outcome: a systematic review
Kaveri T S Aiyer, Lisa J Kroon, Geert J L H van Leenders
Histopathology.2023; 83(3): 339. CrossRef
Survival after radical prostatectomy vs. radiation therapy in ductal carcinoma of the prostate
Francesco Chierigo, Marco Borghesi, Christoph Würnschimmel, Rocco Simone Flammia, Benedikt Horlemann, Gabriele Sorce, Benedikt Höh, Zhe Tian, Fred Saad, Markus Graefen, Michele Gallucci, Alberto Briganti, Francesco Montorsi, Felix K. H. Chun, Shahrokh F.
International Urology and Nephrology.2022; 54(1): 89. CrossRef
Defining Diagnostic Criteria for Prostatic Ductal Adenocarcinoma at Multiparametric MRI
Weranja K. B. Ranasinghe, Patricia Troncoso, Devaki Shilpa Surasi, Juan José Ibarra Rovira, Priya Bhosale, Janio Szklaruk, Andrea Kokorovic, Xuemei Wang, Mohamed Elsheshtawi, Miao Zhang, Ana Aparicio, Brian F. Chapin, Tharakeswara K. Bathala
Radiology.2022; 303(1): 110. CrossRef
Oncological outcomes of patients with ductal adenocarcinoma of the prostate receiving radical prostatectomy or radiotherapy
Mengzhu Liu, Kun Jin, Shi Qiu, Pengyong Xu, Mingming Zhang, Wufeng Cai, Xiaonan Zheng, Lu Yang, Qiang Wei
Asian Journal of Urology.2021; 8(2): 227. CrossRef
Ductal Prostate Cancers Demonstrate Poor Outcomes with Conventional Therapies
Weranja Ranasinghe, Daniel D. Shapiro, Hyunsoo Hwang, Xuemei Wang, Chad A. Reichard, Mohamed Elsheshtawi, Mary F. Achim, Tharakeswara Bathala, Chad Tang, Ana Aparicio, Shi-Ming Tu, Nora Navone, Timothy C. Thompson, Louis Pisters, Patricia Troncoso, John W
European Urology.2021; 79(2): 298. CrossRef
Optimizing the diagnosis and management of ductal prostate cancer
Weranja Ranasinghe, Daniel D. Shapiro, Miao Zhang, Tharakeswara Bathala, Nora Navone, Timothy C. Thompson, Bradley Broom, Ana Aparicio, Shi-Ming Tu, Chad Tang, John W. Davis, Louis Pisters, Brian F. Chapin
Nature Reviews Urology.2021; 18(6): 337. CrossRef
A first case of ductal adenocarcinoma of the prostate having characteristics of neuroendocrine phenotype with PTEN, RB1 and TP53 alterations
Hiroaki Kobayashi, Takeo Kosaka, Kohei Nakamura, Kazunori Shojo, Hiroshi Hongo, Shuji Mikami, Hiroshi Nishihara, Mototsugu Oya
BMC Medical Genomics.2021;[Epub] CrossRef
Knowing what’s growing: Why ductal and intraductal prostate cancer matter
Mitchell G. Lawrence, Laura H. Porter, David Clouston, Declan G. Murphy, Mark Frydenberg, Renea A. Taylor, Gail P. Risbridger
Science Translational Medicine.2020;[Epub] CrossRef
Integrative Genomic Analysis of Coincident Cancer Foci Implicates CTNNB1 and PTEN Alterations in Ductal Prostate Cancer
Marc Gillard, Justin Lack, Andrea Pontier, Divya Gandla, David Hatcher, Adam G. Sowalsky, Jose Rodriguez-Nieves, Donald Vander Griend, Gladell Paner, David VanderWeele
European Urology Focus.2019; 5(3): 433. CrossRef
Genomic Characterization of Prostatic Ductal Adenocarcinoma Identifies a High Prevalence of DNA Repair Gene Mutations
Michael T. Schweizer, Emmanuel S. Antonarakis, Tarek A. Bismar, Liana B. Guedes, Heather H. Cheng, Maria S. Tretiakova, Funda Vakar-Lopez, Nola Klemfuss, Eric Q. Konnick, Elahe A. Mostaghel, Andrew C. Hsieh, Peter S. Nelson, Evan Y. Yu, R. Bruce Montgomer
JCO Precision Oncology.2019; (3): 1. CrossRef

Acid-Fastness of Histoplasma in Surgical Pathology Practice: Madhu Rajeshwari, Immaculata Xess, Mehar Chand Sharma, Deepali Jain; J Pathol Transl Med. 2017;51(5):482-487. Published online September 14, 2017; DOI: https://doi.org/10.4132/jptm.2017.07.11

10,451 View
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Abstract PDF

Background
Histoplasmosis (HP) is diagnosed by visualizing intracellular microorganisms in biopsy and/or culture. Periodic-acid Schiff (PAS) and Gomori methenamine silver (GMS) staining methods are routinely used for identification. The acid-fast property of Histoplasma was identified decades ago, but acid-fast staining has not been practiced in current surgical pathology. Awareness of the acid-fast property of Histoplasma, which is due to mycolic acid in the cell wall, is important in distinguishing Histoplasma from other infective microorganisms. Here, we examined acid-fastness in previously diagnosed cases of Histoplasma using the Ziehl-Neelsen (ZN) stain and correlated those findings with other known fungal stains. Methods: All cases diagnosed as HP were retrieved and reviewed along with ZN staining and other fungal stains. We also stained cases diagnosed with Cryptococcus and Leishmania as controls for comparison. Results: A total of 54 patients ranging in age from 11 to 69 years were examined. The most common sites of infection were the skin, adrenal tissue, and respiratory tract. Of the total 43 tissue samples, 20 (46.5%) stained positive with the ZN stain. In viable cases, a significant proportion of microorganisms were positive while necrotic cases showed only rare ZN-positive yeasts. In comparison to PAS and GMS stains, there was a low burden of ZN-positive yeasts. Cryptococcus showed characteristic ZN staining and all cases of Leishmania were negative. Conclusions: Although the morphology of fungal organisms is the foundation of identification, surgical pathologists should be aware of the acid-fast property of fungi, particularly when there is the potential for confusion with other infective organisms.

Citations

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Disseminated histoplasmosis in an HIV/AIDS transgender male‐to‐female with atypical and persistent GI manifestations
Aaron C Yee, Sarah Huang, Ranbir Singh, Dean Rizzi, Naureen Shama, Neil Khoury, Ilan S Weisberg
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Bernardo Franco, Naurú Idalia Vargas-Maya, Felipe Padilla-Vaca, Fátima Berenice Ramírez-Montiel, José Ascención Martínez-Álvarez
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Placental Lesions in Meconium Aspiration Syndrome: Binnari Kim, Soo-young Oh, Jung-Sun Kim; J Pathol Transl Med. 2017;51(5):488-498. Published online August 9, 2017; DOI: https://doi.org/10.4132/jptm.2017.07.20

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Background
Meconium aspiration syndrome (MAS) is defined by respiratory distress requiring supplemental oxygen in a meconium-stained neonate. MAS is clinically subclassified as mild, moderate, and severe according to the oxygen requirement. The aims of this study were to compare the histological findings in the placentas of MAS neonates with those of meconium-stained but non-MAS neonates and to analyze the correlation between the severity of MAS and the grade of its histological parameters. Methods: We collected 160 singleton term placentas from neonates with meconium staining at birth from a tertiary medical center, Seoul, Republic of Korea. We reviewed hematoxylin and eosin sections of tissue samples (full-thickness placental disc, chorioamniotic membranes, and umbilical cord). Results: Funisitis was present more frequently in MAS than in non-MAS (p < .01), of which the stage was correlated with the severity of MAS (p < .001). The histological findings consistent with maternal underperfusion and chronic deciduitis were more frequent in MAS than in non-MAS (p < .05). There was a correlation between the degree of chorionic vascular muscle necrosis and the severity of MAS (p < .05). Conclusions: Our results suggest that fetal inflammatory response evidenced by funisitis occurs prenatally in MAS and that the stage of funisitis and of chorionic vascular muscle necrosis may be a predictive marker of the severity of MAS.

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Raneen Abu Shqara, Lior Lowenstein, Maya Frank Wolf
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Machine learning‐based placental clusters and their associations with adverse pregnancy outcomes
Julie M. Petersen, Samantha E. Parker, Kimberly A. Dukes, Jennifer A. Hutcheon, Katherine A. Ahrens, Martha M. Werler
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The risk of meconium aspiration syndrome (MAS) increases with gestational age at term
Clara Ward, Aaron B. Caughey
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Protective placental inflammatory and oxidative stress responses are attenuated in the context of twin pregnancy and chorioamnionitis in assisted reproduction
Hayley R. Price, Nick Pang, Hugh Kim, Michael W. H. Coughtrie, Abby C. Collier
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Correlation between Pregnancy Outcome and Placental Pathology in COVID-19 Pregnant Women
Sara A. Al-Rawaf, Enas T. Mousa, Noora M. Kareem, Atif Amin Baig
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Differential impact of antiretroviral therapy initiated before or during pregnancy on placenta pathology in HIV-positive women
Nadia M. Ikumi, Thokozile R. Malaba, Komala Pillay, Marta C. Cohen, Hlengiwe P. Madlala, Mushi Matjila, Dilly Anumba, Landon Myer, Marie-Louise Newell, Clive M. Gray
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Meconium Aspiration Syndrome: A Narrative Review
Chiara Monfredini, Francesco Cavallin, Paolo Ernesto Villani, Giuseppe Paterlini, Benedetta Allais, Daniele Trevisanuto
Children.2021; 8(3): 230. CrossRef
Isolated acute funisitis in the absence of acute chorioamnionitis: What does it mean?
Tracy B. Grossman, Debra S. Heller, Rebecca N. Baergen
Placenta.2019; 75: 42. CrossRef
Influence of foetal inflammation on the development of meconium aspiration syndrome in term neonates with meconium-stained amniotic fluid
Kyoko Yokoi, Osuke Iwata, Satoru Kobayashi, Kanji Muramatsu, Haruo Goto
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Intraosseous Hibernoma: A Rare and Unique Intraosseous Lesion: Boram Song, Hye Jin Ryu, Cheol Lee, Kyung Chul Moon; J Pathol Transl Med. 2017;51(5):499-504. Published online August 22, 2017; DOI: https://doi.org/10.4132/jptm.2017.07.28

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Background
Hibernoma is a rare benign tumor of adults that is composed of multivacuolated adipocytes resembling brown fat cells. Hibernoma typically occurs in soft tissue, and intraosseous examples are very rare. Intraosseous hibernomas can radiologically mimic metastatic carcinoma and other tumorous conditions. Methods: To collect the intraosseous hibernomas, we searched the pathologic database and reviewed the hematoxylin and eosin (H&E)–stained slides of bone biopsy samples performed to differentiate radiologically abnormal bone lesions from 2006 to 2016. A total of six intraosseous hibernoma cases were collected, and clinical and radiological information was verified from electronic medical records. H&E slide review and immunohistochemical staining for CD68, pan-cytokeratin, and S-100 protein were performed. Results: Magnetic resonance imaging of intraosseous hibernomas showed low signal intensity with slightly hyperintense foci on T1 and intermediate to high signal intensity on T2 weighted images. Intraosseous hibernomas appeared as heterogeneous sclerotic lesions with trabecular thickening on computed tomography scans and revealed mild hypermetabolism on positron emission tomography scans. Histopathologically, the bone marrow space was replaced by sheets of multivacuolated, foamy adipocytes resembling brown fat cells, without destruction of bone trabeculae. In immunohistochemical analysis, the tumor cells were negative for CD68 and pan-cytokeratin and positive for S-100 protein. Conclusions: Intraosseous hibernoma is very rare. This tumor can be overlooked due to its rarity and resemblance to bone marrow fat. Pathologists need to be aware of this entity to avoid misdiagnosis of this rare lesion.

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Hibernoma of two contiguous vertebrae: uniqueness of a lesion already rare in itself
Donato MASTRANTUONO, Domenico MARTORANO, Guido REGIS, Federica ARABIA, Alessandra LINARI, Federica SANTORO
Journal of Radiological Review.2022;[Epub] CrossRef
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Spinal Intraosseous Hibernoma: A Case Report and Review of Literature
Mi-Kyung Um, Eugene Lee, Joon Woo Lee, Kyu Sang Lee, Yusuhn Kang, Joong Mo Ahn, Heung Sik Kang
Journal of the Korean Society of Radiology.2020; 81(4): 965. CrossRef
Intraosseous hibernoma: A metastatic mimicker to consider on the differential
Allen Ko, Colin C. Rowell, James B. Vogler, Dmitri E. Samoilov
Radiology Case Reports.2020; 15(12): 2677. CrossRef
Co-expression of MDM2 and CDK4 in transformed human mesenchymal stem cells causes high-grade sarcoma with a dedifferentiated liposarcoma-like morphology
Yu Jin Kim, Mingi Kim, Hyung Kyu Park, Dan Bi Yu, Kyungsoo Jung, Kyoung Song, Yoon-La Choi
Laboratory Investigation.2019; 99(9): 1309. CrossRef
Intraosseous Hibernoma: Five Cases and a Review of the Literature
Francisco A. Myslicki, Andrew E. Rosenberg, Ivan Chaitowitz, Ty K. Subhawong
Journal of Computer Assisted Tomography.2019; 43(5): 793. CrossRef
Hibernoma Mimicking Atypical Lipomatous Tumor
Youssef Al Hmada, Inga-Marie Schaefer, Christopher D.M. Fletcher
American Journal of Surgical Pathology.2018; 42(7): 951. CrossRef

Case Studies

A Rare Case of Aggressive Melanotic Schwannoma Occurred in Spinal Nerve of a 59-Year-Old Male: Sung-eun Choi, Yoon Jin Cha, Jisup Kim, Hyunseo Cha, Jayeong Seo, Sung-Uk Kuh, Sung-Jun Kim, Se Hoon Kim; J Pathol Transl Med. 2017;51(5):505-508. Published online April 4, 2017; DOI: https://doi.org/10.4132/jptm.2017.01.04

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Abstract PDF

Melanotic schwannoma (MS) is a rare variant of nerve sheath neoplasm that shows ultrastructural and immunophenotypical features of Schwann cells but also has cytoplasmic melanosomes and is reactive for melanocytic markers as well. Unlike conventional schwannoma, which is totally benign, MS has an unpredictable prognosis and is thought to have low-malignant potential. Herein, we present a rare case of recurrent MS in lumbar spine of a 59-year-old male.

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Xiaobo Yan, Keyi Wang, Nong Lin, Xin Huang, YanBiao Fu, Zhaoming Ye
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Giulio Bonomo, Alessandro Gans, Elio Mazzapicchi, Emanuele Rubiu, Paolo Alimonti, Marica Eoli, Rosina Paterra, Bianca Pollo, Guglielmo Iess, Francesco Restelli, Jacopo Falco, Francesco Acerbi, Marco Paolo Schiariti, Paolo Ferroli, Morgan Broggi
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Case Report: Cutaneous melanocytic schwannoma with concomitant melanocytoma in a canine
Olwam H. Monakali, Nicolize O'Dell, Louise van der Weyden
Wellcome Open Research.2023; 8: 364. CrossRef
Fine‐needle aspiration cytology of melanotic schwannoma in the submandibular gland
Yu‐Hua Huang, Ying‐Chou Lu, Hsuan‐Ying Huang, Chien‐Chin Chen
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Checkpoint inhibitors and radiotherapy in refractory malignant melanocytic schwannoma with Carney complex: first evidence of efficacy
Jyoti Bajpai, Akhil Kapoor, Rakesh Jalali, Mrinal M Gounder
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18F-FDG PET/CT imaging for aggressive melanotic schwannoma of the L3 spinal root
Xun-Ze Shen, Wei Wang, Zhou-Ye Luo
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Dallas J. Soyland, Dylan R. Goehner, Kayla M. Hoerschgen, Troy D. Gust, Shawn M. Vuong
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Xiangliu OuYang, Lichun Zheng, Xiaoming Zhang
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Seung-Myoung Son, Chang Gok Woo
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Yoshitaka Nagashima, Yusuke Nishimura, Kaoru Eguchi, Takayuki Awaya, Satoshi Yoshikawa, Shoichi Haimoto, Toshihiko Wakabayashi, Masahito Hara
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Zongbin Hou, Teng Shi, Guangrun Li, Lin Tian, Xinna Li, Xiaoyang Liu
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Cytologic Characteristics of Thymic Adenocarcinoma with Enteric Differentiation: A Study of Four Fine-Needle Aspiration Specimens: Ah-Young Kwon, Joungho Han, Hae-yon Cho, Seokhwi Kim, Heejin Bang, Jiyeon Hyeon; J Pathol Transl Med. 2017;51(5):509-512. Published online August 4, 2017; DOI: https://doi.org/10.4132/jptm.2017.03.22

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Thymic adenocarcinoma is extremely rare. Although its histologic features have been occasionally reported, a lack of description of the cytologic features has hampered the prompt and accurate diagnosis of this condition. Herein, we describe the cytologic findings and histology of four aspiration cytology specimens of thymic adenocarcinoma. The specimens were obtained from primary tumors, metastatic lymph nodes, and pericardial effusions. All four specimens showed three-dimensional glandular clusters with a loss of polarity and nuclear overlapping. One specimen had extensive extracellular mucinous material. Three specimens contained tumor cells with intracytoplasmic vacuoles. While the specimen with extracellular mucin showed relatively mild cytologic atypia, other specimens exhibited more atypical cytologic changes: irregular nuclear membranes, a coarse chromatin pattern, and prominent nucleoli. The cytologic features were correlated with the histologic features in each case of enteric type thymic adenocarcinoma. The differential diagnosis included other thymic carcinomas, yolk sac tumors, and metastatic adenocarcinoma from the lung or colorectum.

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Brief Case Report

Iatrogenic Gastric Pseudolipomatosis during Endoscopic Submucosal Dissection: Sang Wook Kim, Woo Sung Moon; J Pathol Transl Med. 2017;51(5):513-515. Published online July 31, 2017; DOI: https://doi.org/10.4132/jptm.2017.04.25

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