Journal of Pathology and Translational Medicine

Case Study

EWSR1 rearranged primary renal myoepithelial carcinoma: a diagnostic conundrum: Nilay Nishith, Zachariah Chowdhury; J Pathol Transl Med. 2023;57(5):284-288. Published online September 15, 2023; DOI: https://doi.org/10.4132/jptm.2023.08.08

1,627 View
197 Download

Abstract PDF: Primary renal myoepithelial carcinoma is an exceedingly rare neoplasm with an aggressive phenotype and Ewing sarcoma breakpoint region 1 (EWSR1) rearrangement in a small fraction of cases. In addition to its rarity, the diagnosis can be challenging for the pathologist due to morphologic heterogeneity, particularly on the biopsy specimen. At times, immunohistochemistry may be indecisive; therefore, molecular studies should be undertaken for clinching the diagnosis. We aim to illustrate a case of primary myoepithelial carcinoma of the kidney with EWSR1-rearrangement in a 67-year-old male patient who presented with right supraclavicular mass, which was clinically diagnosed as carcinoma of an unknown primary. An elaborate immunohistochemical work-up aided by fluorescent in-situ hybridization allowed us to reach a conclusive diagnosis. This unusual case report advocates that one should be aware of the histological mimickers and begin with broad differential diagnoses alongside sporadic ones and then narrow them down with appropriate ancillary studies.

Original Article

Post-mortem assessment of vimentin expression as a biomarker for renal tubular regeneration following acute kidney injury: Juan Carlos Alvarez Moreno, Hisham F. Bahmad, Christopher A. Febres-Aldana, Andrés Pirela, Andres Azuero, Ali Salami, Robert Poppiti; J Pathol Transl Med. 2021;55(6):369-379. Published online October 14, 2021; DOI: https://doi.org/10.4132/jptm.2021.08.03

4,154 View
125 Download
4 Web of Science
4 Crossref

Background
Acute kidney injury (AKI) is a common cause of morbidity and mortality. It mainly targets the renal tubular epithelium with pathological changes, referred to as acute tubular injury. The latter is followed by a regenerative response that is difficult to visualize on routine hematoxylin and eosin (H&E) stains. In this study, we examined the regenerative capacity of renal tubules by correlating vimentin (VIM) immunohistochemical (IHC) expression and pathological findings of AKI and renal tubular regeneration (RTR) on H&E.
Methods
We reviewed 23 autopsies performed in the clinical setting of AKI and RTR. VIM expression was scored in the renal cortical tubular epithelium using a statistical cutoff ≥ 3% for high expression and < 3% for low expression.
Results
Of the 23 kidney tissues examined, seven (30.4%) had low VIM expression, and 16 (69.6%) had high VIM expression. Kidney tissues with evidence of AKI and RTR had significantly higher VIM expression. Renal peritubular microenvironment features showing regenerative changes on H&E were associated with high VIM expression. In the univariate model, kidney tissues with RTR were 18-fold more likely to have high VIM expression.
Conclusions
In conclusion, our findings suggest that VIM could serve as an IHC marker for RTR following AKI. However, correlation with H&E findings remains critical to excluding chronic tubular damage. Collectively, our preliminary results pave the way for future studies including a larger sample size to validate the use of VIM as a reliable biomarker for RTR.

Citations

Citations to this article as recorded by

Myocardial Infarction Injury Is Exacerbated by Nicotine in Vape Aerosol Exposure
Clarissa Savko, Carolina Esquer, Claudia Molinaro, Sophie Rokaw, Abraham G. Shain, Faid Jaafar, Morgan K. Wright, Joy A. Phillips, Tyler Hopkins, Sama Mikhail, Abigail Rieder, Ariana Mardani, Barbara Bailey, Mark A. Sussman
Journal of the American Heart Association.2025;[Epub] CrossRef
Characterization of macrophages in ischemia–reperfusion injury-induced acute kidney injury based on single-cell RNA-Seq and bulk RNA-Seq analysis
Qin Wang, Yuxing Liu, Yan Zhang, Siyuan Zhang, Meifang Zhao, Zhangzhe Peng, Hui Xu, Hao Huang
International Immunopharmacology.2024; 130: 111754. CrossRef
Renal tubular necrosis associated with anagrelide administration: a case report
Atsushi Sawase, Mineaki Kitamura, Misato Morimoto, Haruka Fukuda, Tadashi Uramatsu, Eisuke Katafuchi, Hiroshi Yamashita, Toshiyuki Nakayama, Hiroshi Mukae, Tomoya Nishino
CEN Case Reports.2024; 13(6): 510. CrossRef
Morin attenuates sepsis-induced acute kidney injury by regulating inflammatory responses, oxidative stress and tubular regeneration (morin and sepsis-induced acute kidney injury)
Aya M. Shehata, Nagui H. Fares, Basma H. Amin, Asmaa A. Mahmoud, Yomna I. Mahmoud
Environmental Toxicology and Pharmacology.2024; 111: 104543. CrossRef

Case Studies

Malignant rhabdoid tumor of the kidney in an adult with loss of INI1 expression and mutation in the SMARCB1 gene: Eunkyung Han, Jiyoon Kim, Min Jung Jung, Susie Chin, Sang Wook Lee, Ahrim Moon; J Pathol Transl Med. 2021;55(2):145-153. Published online March 9, 2021; DOI: https://doi.org/10.4132/jptm.2021.01.26

3,181 View
103 Download
4 Web of Science
4 Crossref

Abstract PDF

A 57-year-old man with left flank pain was referred to our institute. Computed tomography scans revealed two enhancing masses in the left kidney. The clinical diagnosis was renal cell carcinoma (RCC). He underwent a radical nephrectomy with an adrenalectomy. Two well-circumscribed solid masses in the hilum and the lower pole (4.5 × 3.5 cm and 7.0 × 4.1 cm) were present. Poorly cohesive uniform round to polygonal epithelioid cells making solid sheets accounted for most of the tumor area. The initial diagnosis was RCC, undifferentiated with rhabdoid features. As the tumor showed loss of INI1 expression and a mutation in the SMARCB1 gene on chromosome 22, the revised diagnosis was a malignant rhabdoid tumor (MRT) of the kidney. To date, only a few cases of renal MRT in adults have been reported. To the best of our knowledge, this is the first report of MRT in the native kidney of an adult demonstrating a SMARCB1 gene mutation, a hallmark of MRT.

Citations

Citations to this article as recorded by

Cancer epigenetic therapy: recent advances, challenges, and emerging opportunities
Rajita Vatapalli, Alex P. Rossi, Ho Man Chan, Jingwen Zhang
Epigenomics.2025; 17(1): 59. CrossRef
Supratentorial ATRT in a young Infant: Expanding the diagnostic spectrum beyond medulloblastoma
Ali Msheik, Mohamad Aoun, Youssef Fares
Interdisciplinary Neurosurgery.2024; 35: 101857. CrossRef
Sarcomatoid and Rhabdoid Renal Cell Carcinoma
Adebowale J. Adeniran, Brian Shuch, Peter A. Humphrey
American Journal of Surgical Pathology.2024; 48(7): e65. CrossRef
Malignant rhabdoid tumor of kidney in an adult patient with positive family history of rhabdoid tumor: A case report and review of literature
Farhood Khaleghi mehr, Nasrollah Abian, Mandana Rahimi, Yasaman Moradi
International Journal of Surgery Case Reports.2023; 113: 109053. CrossRef

Renal intravascular large B cell lymphoma: the first case report in Korea and a review of the literature: Moonsik Kim, Haerim Chung, Woo Ick Yang, Hyeon Joo Jeong; J Pathol Transl Med. 2020;54(5):426-431. Published online August 13, 2020; DOI: https://doi.org/10.4132/jptm.2020.06.18

4,390 View
120 Download
4 Web of Science
4 Crossref

Abstract PDF Supplementary Material

Herein, we describe the first case of renal intravascular large B cell lymphoma in Korea occurring in a 66-year-old female. She presented with mild fever and dyspnea. On physical and laboratory evaluations, hemophagocytic lymphohistiocytosis was suspected, but the bone marrow biopsy results were unremarkable. During the work-up, massive proteinuria developed, which led to a renal biopsy. The renal architecture was relatively well-preserved, but the glomeruli were hypercellular with the infiltration of atypical, large lymphoid cells with increased nucleus-cytoplasm ratio and clumped chromatin. Similar cells were also present in the peritubular capillaries. The tumor cells exhibited membranous staining for CD20 and CD79a. After the diagnosis of intravascular large B cell lymphoma, the patient received rituximab-based chemotherapy under close follow-up.

Citations

Citations to this article as recorded by

EBV-Positive Intravascular Large B-Cell Lymphoma of the Small Intestine: A Case Report and Literature Review
Chenglong Pan, Xiaoling Ma, Yanfei Yao, Chunyan Wang
International Journal of Surgical Pathology.2024; 32(3): 586. CrossRef
Intravascular large B‐cell lymphoma in renal cell carcinoma incidentally detected by robot‐assisted partial nephrectomy
Michio Noda, Yutaka Enomoto, Yukari Shirasugi, Sumiyo Ando, Yukimasa Matsuzawa, Haruki Kume
IJU Case Reports.2022; 5(3): 191. CrossRef
Case Report: Intravascular Large B-Cell Lymphoma: A Clinicopathologic Study of Four Cases With Review of Additional 331 Cases in the Literature
Yingying Han, Qingjiao Li, Dan Wang, Lushan Peng, Tao Huang, Chunlin Ou, Keda Yang, Junpu Wang
Frontiers in Oncology.2022;[Epub] CrossRef
Renal Involvement of CD20-Negative Intravascular Large B Cell Lymphoma with Neurological Manifestations
Faten Aqeel, Serena M. Bagnasco, Duvuru Geetha, Yoshihide Fujigaki
Case Reports in Nephrology.2022; 2022: 1. CrossRef

Clear Cell Renal Cell Carcinoma with Intratumoral Granulomatous Reaction: A Case Report and Review of the Literature: Hayeon Kim, Jong Wook Kim, Aeree Kim, Hyeyoon Chang; J Pathol Transl Med. 2017;51(3):325-328. Published online March 14, 2017; DOI: https://doi.org/10.4132/jptm.2016.09.08

8,261 View
119 Download

Abstract PDF: Granulomatous reaction associated with clear cell renal cell carcinoma (CCRCC) is a rare finding, and only a few cases have been described in the literature. It is postulated to occur due to cancer- related antigenic factors such as cancer cells themselves or soluble tumor antigens shed into the blood. Herein, we describe a case of a 56-year-old male patient diagnosed with CCRCC with intratumoral granulomatous inflammation.

Original Article

Aberrant Blood Vessel Formation Connecting the Glomerular Capillary Tuft and the Interstitium Is a Characteristic Feature of Focal Segmental Glomerulosclerosis-like IgA Nephropathy: Beom Jin Lim, Min Ju Kim, Soon Won Hong, Hyeon Joo Jeong; J Pathol Transl Med. 2016;50(3):211-216. Published online April 11, 2016; DOI: https://doi.org/10.4132/jptm.2016.02.01

7,928 View
72 Download
1 Web of Science
1 Crossref

Abstract PDF

Background
Segmental glomerulosclerosis without significant mesangial or endocapillary proliferation is rarely seen in IgA nephropathy (IgAN), which simulates idiopathic focal segmental glomerulosclerosis (FSGS). We recently recognized aberrant blood vessels running through the adhesion sites of sclerosed tufts and Bowman’s capsule in IgAN cases with mild glomerular histologic change.
Methods
To characterize aberrant blood vessels in relation to segmental sclerosis, we retrospectively reviewed the clinical and histologic features of 51 cases of FSGS-like IgAN and compared them with 51 age and gender-matched idiopathic FSGS cases.
Results
In FSGS-like IgAN, aberrant blood vessel formation was observed in 15.7% of cases, 1.0% of the total glomeruli, and 7.3% of the segmentally sclerosed glomeruli, significantly more frequently than in the idiopathic FSGS cases (p = .009). Aberrant blood vessels occasionally accompanied mild cellular proliferation surrounding penetrating neovessels. Clinically, all FSGS-like IgAN cases had hematuria; however, nephrotic range proteinuria was significantly less frequent than idiopathic FSGS.
Conclusions
Aberrant blood vessels in IgAN are related to glomerular capillary injury and may indicate abnormal repair processes in IgAN.

Citations

Citations to this article as recorded by

IgA nephropathy
Maria F. Soares, Ian S.D. Roberts
Current Opinion in Nephrology and Hypertension.2017; 26(3): 165. CrossRef

Case Study

Silent Colonic Malakoplakia in a Living-Donor Kidney Transplant Recipient Diagnosed during Annual Medical Examination: Go Eun Bae, Nara Yoon, Ha Young Park, Sang Yun Ha, Junhun Cho, Yunkyung Lee, Kyoung-Mee Kim, Cheol Keun Park; Korean J Pathol. 2013;47(2):163-166. Published online April 24, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.2.163

6,735 View
57 Download
8 Crossref

Abstract PDF

Malakoplakia is a characteristic inflammatory condition, which is usually seen in the urogenital tract, and less frequently in the gastrointestinal tract. We present a case of colonic malakoplakia in an immunocompromised patient. A 55-year-old female visited the outpatient clinic for routine cancer surveillance. Her past medical history was significant for kidney transplantation 11 years ago, and she had been taking immunosuppressants. A colonoscopy revealed several depressed flat lesions and elevated polyps, which were 0.3 to 0.4 cm in size and accompanied by whitish exudates. A biopsy revealed an infiltration of histiocytes with ample granular eosinophilic cytoplasm, with some lymphocytes and plasma cells. Many histiocytes had the characteristic morphology, described as Michaelis-Gutmann bodies: one or several round basophilic structures of approximately 1 to 10 µm in size with some being laminated, some appearing homogeneous, and others having a dense central core with a targetoid appearance. These Michaelis-Gutmann bodies were positively stained on von Kossa stain, and were diagnostic for malakoplakia.

Citations

Citations to this article as recorded by

Caecal malakoplakia: a rare mimic of malignancy
Jeffrey Li Voon Chong, Noor Ali
BMJ Case Reports.2024; 17(1): e257130. CrossRef
A Surgical Challenge Generated by Colonic Malakoplakia in Disguise as a Locally Advanced Colonic Malignancy—A Case Report
Cristina Șerban, Alexandra Toma, Dragoș Cristian Voicu, Constantin Popazu, Dorel Firescu, George Țocu, Raul Mihailov, Laura Rebegea
Medicina.2023; 59(1): 156. CrossRef
Colonic malakoplakia in a cardiac transplant recipient: A case report
Sadiya Shafijan
Indian Journal of Pathology and Microbiology.2020; 63(2): 322. CrossRef
Immunosuppressive drugs and the gastrointestinal tract in renal transplant patients
Merel M. Tielemans, Gerben A.J. van Boekel, Teun van Gelder, Eric T. Tjwa, Luuk B. Hilbrands
Transplantation Reviews.2019; 33(2): 55. CrossRef
Malakoplakia of the colon following renal transplantation in a 73 year old woman: report of a case presenting as intestinal perforation
Andrew Mitchell, Alexandre Dugas
Diagnostic Pathology.2019;[Epub] CrossRef
Colonic malakoplakia in a liver transplant recipient: A case report
Rana Ajabnoor, Mohammad Mawardi, Abdulmonem Almutawa
Human Pathology: Case Reports.2019; 18: 200323. CrossRef
Malakoplakia after kidney transplantation: Case report and literature review
John Fredy Nieto‐Ríos, Isabel Ramírez, Mónica Zuluaga‐Quintero, Lina María Serna‐Higuita, Federico Gaviria‐Gil, Alejandro Velez‐Hoyos
Transplant Infectious Disease.2017;[Epub] CrossRef
Megalocytic Interstitial Nephritis Following Acute Pyelonephritis with Escherichia coli Bacteremia: A Case Report
Hee Jin Kwon, Kwai Han Yoo, In Young Kim, Seulkee Lee, Hye Ryoun Jang, Ghee Young Kwon
Journal of Korean Medical Science.2015; 30(1): 110. CrossRef

Case Reports

Castleman's Disease of the Renal Sinus Presenting as a Urothelial Malignancy: A Brief Case Report: Se Min Jang, Hulin Han, Ki-Seok Jang, Young Jin Jun, Tchun Yong Lee, Seung Sam Paik; Korean J Pathol. 2012;46(5):503-506. Published online October 25, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.5.503

7,143 View
45 Download
4 Crossref

Abstract PDF

Castleman's disease is a rare benign lymphoproliferative disorder that frequently affects lymph nodes of the mediastinal thorax and the neck. It very rarely affects the renal sinus. We report a case of Castleman's disease arising in the renal sinus in a 64-year-old man. The patient visited the hospital with the chief complaint of hematuria. Abdominal computed tomography revealed a homogeneous mass in the sinus of the left kidney, radiologically interpreted as a malignant urothelial tumor. Subsequently, nephroureterectomy was performed, after which microscopic examination of the specimen revealed a diffuse lymphoproliferative lesion with reactive lymphoid follicles of various sizes and prominent plasma cell infiltration of interfollicular spaces, highlighted by immunohistochemical staining for CD138. The lesion was diagnosed as Castleman's disease of the plasma cell type. Although preoperative diagnosis of Castleman's disease is difficult and the incidence is exceedingly rare, it should be considered in the differential diagnosis of renal sinus tumors.

Citations

Citations to this article as recorded by

Misdiagnosis of renal pelvic unicentric Castleman disease: a case report
Dian Fu, Bo Yang, Ming Yang, Zhenyu Xu, Wen Cheng, Zhijia Liu, Liming Zhang, Zhiguo Mao, Cheng Xue
Frontiers in Surgery.2023;[Epub] CrossRef
Case report: Castleman’s disease involving the renal sinus resembling renal cell carcinoma
Enlong Zhang, Yuan Li, Ning Lang
Frontiers in Surgery.2022;[Epub] CrossRef
Radiologic features of Castleman’s disease involving the renal sinus: A case report and review of the literature
Xiao-Wan Guo, Xu-Dong Jia, Shan-Shan Shen, Hong Ji, Ying-Min Chen, Qian Du, Shu-Qian Zhang
World Journal of Clinical Cases.2019; 7(8): 1001. CrossRef
Castleman’s Disease: a Suprarenal Surprise!
Praveen Sundar, Priyank Bijalwan, Ginil Kumar Pooleri
Indian Journal of Surgical Oncology.2018; 9(2): 254. CrossRef

Pigmented Perivascular Epithelioid Cell Tumor (PEComa) of the Kidney: A Case Report and Review of the Literature: Hyeyoon Chang, Wonkyung Jung, Youngran Kang, Woon Yong Jung; Korean J Pathol. 2012;46(5):499-502. Published online October 25, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.5.499

8,236 View
72 Download
10 Crossref

Abstract PDF

Heavily pigmented perivascular epithelioid cell tumors (PEComa) are rare, only eight cases of which have been reported. Unlike typical epithelioid angiomyolipoma, most of these tumors have been encountered in female patients without tuberous sclerosis. The long-term prognosis thereof is undetermined. Cytological similarity and heavy melanin pigment make it difficult for pigmented PEComa to be differentiated from pigmented clear cell renal cell carcinoma or malignant melanoma. The immunoprofile of tumor cells, such as human melanoma black-45 expression, as well as the absence or presence of other melanocytic or epithelial markers, are helpful in determining a differential diagnosis. Here we report a case of heavily pigmented PEComa of the right kidney and review the literature describing this tumor. In this case, the immunoprofile and clinical features corresponded well to those described in the literature. Since the prognosis of such disease has not yet been established, close follow-up of this patient was recommended.

Citations

Citations to this article as recorded by

Tumor de células epitelioides perivasculares (PEComa) primário do rim: uma revisão sistemática
Eric Lima Freitas Mota, Mariana Macambira Noronha, Letícia Pinheiro Amorim, João Luiz Lima Pinheiro, Eduarda Severo Alvarenga, Paulo Eduardo de Oliveira, Fabrícia Cardoso Marques, Emmanuel Apollo de Macedo Ferreira
Cuadernos de Educación y Desarrollo.2024; 16(12 Edição ): e6498. CrossRef
Malignant Pigmented Epithelioid Angiomyolipoma of the Kidney in a Child with Tuberous Sclerosis Complex
Thu Dang Anh Phan, Nhi Thuy To, Diem Thi Nhu Pham
Fetal and Pediatric Pathology.2023; 42(2): 285. CrossRef
Perivascular epithelioid cell tumor (PEComa) of the cystic duct
Takeshi Okamoto, Takashi Sasaki, Yu Takahashi, Manabu Takamatsu, Hiroaki Kanda, Makiko Hiratsuka, Masato Matsuyama, Masato Ozaka, Naoki Sasahira
Clinical Journal of Gastroenterology.2023; 16(1): 87. CrossRef
PEComa of the Adrenal Gland
Craig B. Wakefield, Peter M. Sadow, Jason L. Hornick, Christopher D.M. Fletcher, Justine A. Barletta, William J. Anderson
American Journal of Surgical Pathology.2023; 47(11): 1316. CrossRef
Recurrence of Pigmented Epithelioid Angiomyolipoma of the Kidney With Xp11 Translocation: A Case Report
Mahmoud D Srour, Andrew Harris
Cureus.2023;[Epub] CrossRef
Pigmented perivascular epithelioid cell tumor (PEComa) arising from kidney
Hexi Du, Jun Zhou, Lingfan Xu, Cheng Yang, Li Zhang, Chaozhao Liang
Medicine.2016; 95(44): e5248. CrossRef
PEComas of the kidney and of the genitourinary tract
Guido Martignoni, Maurizio Pea, Claudia Zampini, Matteo Brunelli, Diego Segala, Giuseppe Zamboni, Franco Bonetti
Seminars in Diagnostic Pathology.2015; 32(2): 140. CrossRef
Pigmented Perivascular Epithelioid Cell Tumor of the Skin
Pooja Navale, Masoud Asgari, Sheng Chen
The American Journal of Dermatopathology.2015; 37(11): 866. CrossRef
Clear Cell Melanoma: A Cutaneous Clear Cell Malignancy
Maria A. Pletneva, Aleodor Andea, Nallasivam Palanisamy, Bryan L. Betz, Shannon Carskadon, Min Wang, Rajiv M. Patel, Douglas R. Fullen, Paul W. Harms
Archives of Pathology & Laboratory Medicine.2014; 138(10): 1328. CrossRef
Extrapulmonary Lymphangioleiomyoma: Clinicopathological Analysis of 4 Cases
Dae Hyun Song, In Ho Choi, Sang Yun Ha, Kang Min Han, Jae Jun Lee, Min Eui Hong, Yoon-La Choi, Kee-Taek Jang, Sang Yong Song, Chin A Yi, Joungho Han
Korean Journal of Pathology.2014; 48(3): 188. CrossRef

Multifocal Renal Cell Carcinoma of Different Histological Subtypes in Autosomal Dominant Polycystic Kidney Disease: Ki Yong Na, Hyun-Soo Kim, Yong-Koo Park, Sung-Goo Chang, Youn Wha Kim; Korean J Pathol. 2012;46(4):382-386. Published online August 23, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.4.382

8,539 View
70 Download
11 Crossref

Abstract PDF

Renal cell carcinoma (RCC) in autosomal dominant polycystic kidney (ADPKD) is rare. To date, 54 cases of RCC in ADPKD have been reported. Among these, only 2 cases have different histologic types of RCC. Here we describe a 45-year-old man who received radical nephrectomy for multifocal RCC with synchronous papillary and clear cell histology in ADPKD and chronic renal failure under regular hemodialysis. The case reported herein is another example of the rare pathological finding of RCC arising in a patient with ADPKD.

Citations

Citations to this article as recorded by

Renal Cell Carcinoma in the Background of Autosomal Dominant Polycystic Kidney Disease: Report of Two Cases and Review of Literature
Poorva Vias, Shikha Goyal, Renu Madan, Nandita Kakkar, Ridhi Sood, Kannan Periasamy, Rajender Kumar
Indian Journal of Medical and Paediatric Oncology.2024; 45(02): 188. CrossRef
Detection of two synchronous histologically different renal cell carcinoma subtypes in the same kidney: a case report and review of the literature
Mohamed Sakr, Merhan Badran, Sarah Ahmed Hassan, Mohamed Elsaqa, Mohamed Anwar Elwany, Nevine M. F. El Deeb, Mohamed Sharafeldeen
Journal of Medical Case Reports.2024;[Epub] CrossRef
The Importance of Genetic Testing in the Differential Diagnosis of Atypical TSC2-PKD1 Contiguous Gene Syndrome—Case Series
Petronella Orosz, Zita Kollák, Ákos Pethő, András Fogarasi, György Reusz, Kinga Hadzsiev, Tamás Szabó
Children.2023; 10(3): 420. CrossRef
Autosomal dominant polycystic kidney disease coming up with an unusual presentation of renal cell carcinoma on its first encounter
Asma Shoukat Masumdar, Anitha Padmanabhan, Nitin Gadgil, Gargi Padalkar
Indian Journal of Pathology and Oncology.2023; 10(4): 417. CrossRef
Sarcomatoid renal cell carcinoma with autosomal dominant polycystic kidney disease: a case report and literature review
Yuji Hakozaki, Kiyotaka Uchiyama, Akane Yanai, Daisuke Yamada, Yuka Kamijo, Yoshitaka Ishibashi
CEN Case Reports.2021; 10(2): 199. CrossRef
CT and MRI findings of cystic renal cell carcinoma: comparison with cystic collecting duct carcinoma
Qingqiang Zhu, Jun Ling, Jing Ye, Wenrong Zhu, Jingtao Wu, Wenxin Chen
Cancer Imaging.2021;[Epub] CrossRef
Incidental occurrence of papillary renal cell carcinoma in the native kidney with autosomal dominant polycystic kidney disease after renal transplantation: A case report
Mahmoud Abbas, Melanie Pätzel, Angelika Thurn, Olaf Brinkmann, Olaf Bettendorf
Molecular and Clinical Oncology.2021;[Epub] CrossRef
Xp11.2 translocation renal cell carcinoma in the autosomal dominant polycystic kidney disease patient with preserved renal function
Hyuk Huh, Hyung Ah Jo, YongJin Yi, Seung Hyup Kim, Kyung Chul Moon, Curie Ahn, Hayne Cho Park
The Korean Journal of Internal Medicine.2017; 32(6): 1108. CrossRef
The Association between Autosomal Dominant Polycystic Kidney Disease and Renal Cell Carcinoma
Chase C. Hansen, Michael Derrick, Irfan Warriach, James Thomas Cammack, James Thomas Cammack, Werner de Riese
Open Journal of Urology.2015; 05(06): 84. CrossRef
The MSCT and MRI findings of collecting duct carcinoma
Q. Zhu, J. Wu, Z. Wang, W. Zhu, W. Chen, S. Wang
Clinical Radiology.2013; 68(10): 1002. CrossRef
Thyroid-like follicular carcinoma of the kidney in a patient with nephrolithiasis and polycystic kidney disease: a case report
Metka Volavšek, Margareta Strojan-Fležar, Gregor Mikuz
Diagnostic Pathology.2013;[Epub] CrossRef

Hyaline Vascular Castleman Disease Involving Renal Parenchyma and a Lymph Node: A Case Report: Ji Hyun Kwon, Soo Kee Min, Mi Kyung Shin, Yong Seong Lee, Young-Goo Lee, Young Hyeh Ko; Korean J Pathol. 2012;46(1):79-82. Published online February 23, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.1.79

7,811 View
52 Download
4 Crossref

Abstract PDF

Castleman disease is a rare lymphoproliferative lesion that is predominantly found in the mediastinum. Retroperitoneal and pararenal localizations are very rare. We describe a 36-year-old man with a hyaline vascular type of Castleman disease involving renal parenchyma and a paraaortic lymph node. Most reported renal Castleman disease was plasma cell type with systemic symptoms. Herein, we report the first Korean case of the hyaline vascular type of Castleman disease involving the renal parenchyma and the paraaortic lymph node simultaneously.

Citations

Citations to this article as recorded by

Castleman Disease of the Kidney in Computed Tomography Urography
Kai Wang, Fengjuan Xing, Heng Ma, Wenjuan Li
Current Medical Imaging Formerly Current Medical Imaging Reviews.2022; 18(1): 74. CrossRef
Primary hyaline vascular Castleman disease of the kidney: case report and literature review
Yunzhu Li, Haixia Zhao, Bingyin Su, Chan Yang, Shurong Li, Wanlei Fu
Diagnostic Pathology.2019;[Epub] CrossRef
Castleman’s Disease of the Kidney Mimicking Renal Cell Carcinoma on FDG PET/CT
Yang Wang, Aisheng Dong, Bo Yang, Jianping Lu
Clinical Nuclear Medicine.2018; 43(5): e160. CrossRef
Unicentric hyaline vascular type of castleman disease of the renal hilum with diagnostic dilemma: A case report and review of literature
AmitKumar Adhya, ManasRanjan Pradhan
Oncology Journal of India.2018; 2(4): 96. CrossRef

Original Articles

Prognostic Significance and Nature of Rhabdoid Features in Renal Cell Carcinoma.: Misun Choe, Ji Young Park, Ilseon Hwang, Sang Pyo Kim; Korean J Pathol. 2011;45(4):371-378.; DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.4.371

3,646 View
30 Download

Abstract PDF: BACKGROUND
Recent reports have indicated that renal cell carcinoma (RCC) with rhabdoid features follows an aggressive clinical course. We investigated the prognostic significance and nature of the rhabdoid component.
METHODS
We retrospectively analyzed the incidence and clinicopathologic characteristics of RCC with rhabdoid features in 174 radical nephrectomy cases. The specimens were examined histologically and immunohistochemically.
RESULTS
Twelve of the 174 RCC cases (6.9%) showed rhabdoid features. Histologically, all the tumors with rhabdoid features were of the clear cell type. The presence of rhabdoid features was significantly associated with higher Fuhrman's nuclear grade and higher pathologic tumor stage at presentation. Among the 12 patients who showed the rhabdoid component, nine (75%) developed metastasis and seven (58.3%) died of disease-related causes. The presence of rhabdoid features was independently associated with metastasis and disease-related mortality. The rhabdoid cells were positive for vimentin; variably positive for pan-cytokeratin, epithelial membrane antigen, and CD10; and negative for cytokeratin 7, smooth muscle actin, desmin, E-cadherin, and c-Kit. No case showed loss of integrase interactor-1; one was p53 positive, and five were insulin-like growth factor mRNA binding protein 3 positive. The Ki-67 labeling index was 1-25% (mean, 5.5%).
CONCLUSIONS
The rhabdoid component is an independent prognostic factor for metastasis of RCC; therefore, identification of this component is critical.

Comparison of Detecting Methods of BK Virus Infection in Patients with Renal Allograft Recipients.: Sung Hak Lee, Youn Jun Park, Chul Woo Yang, Yong Soo Kim, In Sung Moon, Chang Suk Kang, Yeong Jin Choi; Korean J Pathol. 2010;44(6):636-641.; DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.6.636

3,608 View
24 Download
2 Crossref

Abstract PDF

BACKGROUND
BK virus nephropathy (BKVN) is an emerging problem as a consequence of the use of potent immunosuppressive agents. Because optimal detection methods for the diagnosis of BKVN are required clinically, we compared the results of renal allograft biopsy, urine cytology, and urine and blood viral loads.
METHODS
Four hundred sixty two case notes from 2004 to 2009 at Seoul St. Mary's Hospital were reviewed. During that period, 286 cases of urine cytology for decoy cells, 938 cases of urine BKV reverse transcription-polymerase chain reaction (RT-PCR), and 1,029 cases of blood BKV RT-PCR were performed. All diagnostic methods were performed in 85 cases.
RESULTS
A histological diagnosis of BKVN was made in 2.4% of cases (11/462). Urine cytology for decoy cells was positive in 26.2% (75/286). BKV RT-PCR revealed viruria in positivity of 22.1% (207/938) and viremia in 5.2% (54/1,029). In cases of BKVN, the sensitivities of urine and blood BKV RT-PCR were all 100% and the specificities were 69% and 94.5%, respectively. In cases with positive urine decoy cells, the sensitivities of urine and blood BKV RT-PCR were 50% and 27.7%, with specificities of 77.7% and 100%, respectively.
CONCLUSIONS
BKV screening by RT-PCR assays may be a clinically useful noninvasive test to identify renal recipients with concurrent BKVN.

Citations

Citations to this article as recorded by

Prevalence of BK Virus among Iranian Renal Transplant Recipients: A Systematic Review and Meta-Analysis
Mohsen Ebrahimi, Alireza Mohebbi, Mohammad Mostakhdem Hashemi, Mobina Ashrafi Shahmirzadi
Journal of Clinical and Basic Research.2020; 4(4): 50. CrossRef
Asymptomatic hematuria associated with urinary polyomavirus infection in immunocompetent patients
Sung Hak Lee, Sung Hoo Hong, Ji Youl Lee, Tae Kon Hwang, Kyoung Suk Kim, Hyoungnam Lee, Yeong Jin Choi
Journal of Medical Virology.2014; 86(2): 347. CrossRef

Practical Standardization in Renal Biopsy Reporting.: So Young Jin, Hyeon Joo Jeong, Sun Hee Sung, Beom Jin Lim, Jee Young Han, Soon Won Hong, Hyun Ee Yim, Yeong Jin Choi, Yong Mee Cho, Myoung Jae Kang, Kyung Chul Moon, Hee Jeong Cha, Seung Yeon Ha, Mi Seon Kang, Mee Young So, Kwang Sun Suh, Jong Eun Joo, Yong Jin Kim, Nam Hee Won, Moon Hyang Park; Korean J Pathol. 2010;44(6):613-622.; DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.6.613

4,605 View
161 Download
2 Crossref

Abstract PDF

BACKGROUND
To standardize renal biopsy reporting and diagnosis, The Renal Pathology Study Group of the Korean Society of Pathologists (RPSKSP) has developed a renal pathology reporting format for the native and allograft kidney.
METHODS
A consensus checklist of a provisional renal biopsy format was sent to all members of the RPSKSP. Feed back opinions regarding the practical application of the checklist to the diagnostic work were received.
RESULTS
Kidney biopsies require three essential examinations: by light microscopy, immunofluorescence (IF), and electron microscopy (EM). A final report of a renal biopsy should include information on specimen adequacy and a description of the morphologic change using a systematic semiquantitative method for each of the compartments, with optional separate IF and EM reports.
CONCLUSIONS
A standard renal biopsy report format is important in establishing clinicopathologic correlations, making reliable prognostic considerations, comparing the findings in sequential biopsies and evaluating the effects of therapy.

Citations

Citations to this article as recorded by

Additional antihypertensive effect of magnesium supplementation with an angiotensin II receptor blocker in hypomagnesemic rats
Kyubok Jin, Tae Hee Kim, Yeong Hoon Kim, Yang Wook Kim
The Korean Journal of Internal Medicine.2013; 28(2): 197. CrossRef
Clinicopathologic Features of IgA-Dominant Postinfectious Glomerulonephritis
Tai Yeon Koo, Gheun-Ho Kim, Hyang Park
Korean Journal of Pathology.2012; 46(2): 105. CrossRef

Case Report

Solitary Fibrous Tumor of the Kidney: A Report of Two Cases with Review of Literature.: Sun A Kim, Jung Eun Hwang, Jae Y Ro, Kyung Ja Cho, Cheryn Song, Mi Jung Kim; Korean J Pathol. 2010;44(4):420-425.; DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.4.420

3,618 View
22 Download
2 Crossref

Abstract PDF

Solitary fibrous tumor (SFT) is a benign mesenchymal neoplasm usually occurring in the pleura. Kidney is one of the rarest sites for SFT. We report here on two cases of renal SFT found in 30-year-old and 33-year-old men with review of the literatures. Both cases manifested as well-enhanced solid masses in kidney and radical nephrectomies were done. The tumors consisted of bland-looking spindle cells arranged in short, ill-defined fascicles and storiform pattern with characteristic hemangiopericytoma-like blood vessels. The tumor cells were strongly positive for CD34 and CD99, focally positive for bcl-2, and negative for cytokeratin and human melanoma black-45 on immunohistochemical stainings. Possibility of SFT should be considered in the differential diagnosis of a renal mass which consists of benign-looking spindle cells and hemangiopericytomatous blood vessels. Immunohistochemical staining for CD34 is essential to confirm the renal solitary fibrous tumor.

Citations

Citations to this article as recorded by

Solitary fibrous tumor located in the sella turcica: A report of two cases and review of the literature
XIAO YANG, QINGJUN JIANG, BINGBING YU
Oncology Letters.2015; 10(1): 354. CrossRef
Pediatric Renal Solitary Fibrous Tumor
William W. Wu, Julia T. Chu, Stephen G. Romansky, Lisa Shane
International Journal of Surgical Pathology.2015; 23(1): 34. CrossRef

First
Prev
Page of 5
Next
Last

Search