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Inflammatory bowel disease–associated intestinal fibrosis
Ji Min Park, Jeongseok Kim, Yoo Jin Lee, Sung Uk Bae, Hye Won Lee
J Pathol Transl Med. 2023;57(1):60-66.   Published online January 10, 2023
DOI: https://doi.org/10.4132/jptm.2022.11.02
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  • 326 Download
  • 16 Web of Science
  • 15 Crossref
AbstractAbstract PDF
Fibrosis is characterized by a proliferation of fibroblasts and excessive extracellular matrix following chronic inflammation, and this replacement of organ tissue with fibrotic tissue causes a loss of function. Inflammatory bowel disease (IBD) is a chronic inflammation of the gastrointestinal tract, and intestinal fibrosis is common in IBD patients, resulting in several complications that require surgery, such as a stricture or penetration. This review describes the pathogenesis and various factors involved in intestinal fibrosis in IBD, including cytokines, growth factors, epithelial-mesenchymal and endothelial-mesenchymal transitions, and gut microbiota. Furthermore, histopathologic findings and scoring systems used for stenosis in IBD are discussed, and differences in the fibrosis patterns of ulcerative colitis and Crohn’s disease are compared. Biomarkers and therapeutic agents targeting intestinal fibrosis are briefly mentioned at the end.

Citations

Citations to this article as recorded by  
  • Resistance to apoptosis in complicated Crohn's disease: Relevance in ileal fibrosis
    M. Seco-Cervera, D. Ortiz-Masiá, D.C. Macias-Ceja, S. Coll, L. Gisbert-Ferrándiz, J. Cosín-Roger, C. Bauset, M. Ortega, B. Heras-Morán, F. Navarro-Vicente, M. Millán, J.V. Esplugues, S. Calatayud, M.D. Barrachina
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2024; 1870(2): 166966.     CrossRef
  • Characterization of patient-derived intestinal organoids for modelling fibrosis in Inflammatory Bowel Disease
    Ilaria Laudadio, Claudia Carissimi, Noemi Scafa, Alex Bastianelli, Valerio Fulci, Alessandra Renzini, Giusy Russo, Salvatore Oliva, Roberta Vitali, Francesca Palone, Salvatore Cucchiara, Laura Stronati
    Inflammation Research.2024; 73(8): 1359.     CrossRef
  • Food additives impair gut microbiota from healthy individuals and IBD patients in a colonic in vitro fermentation model
    Irma Gonza, Elizabeth Goya-Jorge, Caroline Douny, Samiha Boutaleb, Bernard Taminiau, Georges Daube, Marie–Louise Scippo, Edouard Louis, Véronique Delcenserie
    Food Research International.2024; 182: 114157.     CrossRef
  • Epigenetic Regulation of EMP/EMT-Dependent Fibrosis
    Margherita Sisto, Sabrina Lisi
    International Journal of Molecular Sciences.2024; 25(5): 2775.     CrossRef
  • Mechanisms and therapeutic research progress in intestinal fibrosis
    Yanjiang Liu, Tao Zhang, Kejian Pan, He Wei
    Frontiers in Medicine.2024;[Epub]     CrossRef
  • Disease clearance in ulcerative colitis: A new therapeutic target for the future
    Syed Adeel Hassan, Neeraj Kapur, Fahad Sheikh, Anam Fahad, Somia Jamal
    World Journal of Gastroenterology.2024; 30(13): 1801.     CrossRef
  • Urinary Hydroxyproline as an Inflammation-Independent Biomarker of Inflammatory Bowel Disease
    Muriel Huss, Tanja Elger, Johanna Loibl, Arne Kandulski, Benedicta Binder, Petra Stoeckert, Patricia Mester, Martina Müller, Christa Buechler, Hauke Christian Tews
    Gastroenterology Insights.2024; 15(2): 486.     CrossRef
  • Inflammatory Bowel Disease: Immune Function, Tissue Fibrosis and Current Therapies
    Jesús Cosín-Roger
    International Journal of Molecular Sciences.2024; 25(12): 6416.     CrossRef
  • The Diagnosis of Intestinal Fibrosis in Crohn’s Disease—Present and Future
    Sara Jarmakiewicz-Czaja, Jolanta Gruszecka, Rafał Filip
    International Journal of Molecular Sciences.2024; 25(13): 6935.     CrossRef
  • Role of gut microbiota in Crohn’s disease pathogenesis: Insights from fecal microbiota transplantation in mouse model
    Qiang Wu, Lian-Wen Yuan, Li-Chao Yang, Ya-Wei Zhang, Heng-Chang Yao, Liang-Xin Peng, Bao-Jia Yao, Zhi-Xian Jiang
    World Journal of Gastroenterology.2024; 30(31): 3689.     CrossRef
  • Ultrasound of the bowel with a focus on IBD: the new best practice
    Christina Merrill, Stephanie R. Wilson
    Abdominal Radiology.2024;[Epub]     CrossRef
  • Unveiling the anti-inflammatory potential of 11β,13-dihydrolactucin for application in inflammatory bowel disease management
    Melanie S. Matos, María Ángeles Ávila-Gálvez, Antonio González-Sarrías, Nuno-Valério Silva, Carolina Lage Crespo, António Jacinto, Ana Teresa Serra, Ana A. Matias, Cláudia Nunes dos Santos
    Food & Function.2024; 15(18): 9254.     CrossRef
  • Pathways Affected by Falcarinol-Type Polyacetylenes and Implications for Their Anti-Inflammatory Function and Potential in Cancer Chemoprevention
    Ruyuf Alfurayhi, Lei Huang, Kirsten Brandt
    Foods.2023; 12(6): 1192.     CrossRef
  • Time to eRAASe chronic inflammation: current advances and future perspectives on renin-angiotensin-aldosterone-system and chronic intestinal inflammation in dogs and humans
    Romy M. Heilmann, Georg Csukovich, Iwan A. Burgener, Franziska Dengler
    Frontiers in Veterinary Science.2023;[Epub]     CrossRef
  • Role of the epithelial barrier in intestinal fibrosis associated with inflammatory bowel disease: relevance of the epithelial-to mesenchymal transition
    Dulce C. Macias-Ceja, M. Teresa Mendoza-Ballesteros, María Ortega-Albiach, M. Dolores Barrachina, Dolores Ortiz-Masià
    Frontiers in Cell and Developmental Biology.2023;[Epub]     CrossRef
Original Article
Article image
Prognostic significance of BLK expression in R-CHOP treated diffuse large B-cell lymphoma
Soyeon Choi, Yoo Jin Lee, Yunsuk Choi, Misung Kim, Hyun-Jung Kim, Ji Eun Kim, Sukjoong Oh, Seoung Wan Chae, Hee Jeong Cha, Jae-Cheol Jo
J Pathol Transl Med. 2022;56(5):281-288.   Published online September 13, 2022
DOI: https://doi.org/10.4132/jptm.2022.07.26
  • 2,366 View
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  • 1 Crossref
AbstractAbstract PDF
Background
The aim of the present study was to evaluate the prognostic significance of B-cell lymphocyte kinase (BLK) expression for survival outcomes in diffuse large B-cell lymphoma (DLBCL) patients treated with R-CHOP.
Methods
We retrospectively analyzed the medical records of 89 patients from two tertiary referral hospitals. The expression of BLK, SYK, and CDK1 were evaluated in a semiquantitative method using an H-score, and the proportions of BCL2 and C-MYC were evaluated.
Results
A total of 89 patients received R-CHOP chemotherapy as a first-line chemotherapy. The expression rates of BLK in tumor cells was 39.2% (n = 34). BLK expression status was not significantly associated with clinical variables; however, BLK expression in tumor cells was significantly associated with the expression of both C-MYC and BCL2 (p = .003). With a median follow-up of 60.4 months, patients with BLK expression had significantly lower 5-year progression-free survival (PFS) and overall survival rates (49.8% and 60.9%, respectively) than patients without BLK expression (77.3% and 86.7%, respectively). In multivariate analysis for PFS, BLK positivity was an independent poor prognostic factor (hazard ratio, 2.208; p = .040).
Conclusions
Here, we describe the clinicopathological features and survival outcome according to expression of BLK in DLBCL. Approximately 39% of DLBCL patients showed BLK positivity, which was associated as a predictive marker for poor prognosis in patients who received R-CHOP chemotherapy.

Citations

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  • Exploring the cell-free total RNA transcriptome in diffuse large B-cell lymphoma and primary mediastinal B-cell lymphoma patients as biomarker source in blood plasma liquid biopsies
    Philippe Decruyenaere, Edoardo Giuili, Kimberly Verniers, Jasper Anckaert, Katrien De Grove, Malaïka Van der Linden, Dries Deeren, Jo Van Dorpe, Fritz Offner, Jo Vandesompele
    Frontiers in Oncology.2023;[Epub]     CrossRef
Case Study
Article image
Morule-like features in pulmonary adenocarcinoma associated with epidermal growth factor receptor mutations: two case reports with targeted next-generation sequencing analysis
Yoo Jin Lee, Harim Oh, Eojin Kim, Bokyung Ahn, Jeong Hyeon Lee, Youngseok Lee, Yang Seok Chae, Chul Hwan Kim
J Pathol Transl Med. 2020;54(1):119-122.   Published online November 1, 2019
DOI: https://doi.org/10.4132/jptm.2019.09.30
  • 4,720 View
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  • 2 Web of Science
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AbstractAbstract PDF
Morules, or morule-like features, can be identified in benign and malignant lesions in various organs. Morular features are unusual in pulmonary adenocarcinoma cases with only 26 cases reported to date. Here, we describe two cases of pulmonary adenocarcinoma with morule-like features in Korean women. One patient had a non-mucinous-type adenocarcinoma in situ and the other had an acinarpredominant adenocarcinoma with a micropapillary component. Both patients showed multiple intra-alveolar, nodular, whorled proliferative foci composed of atypical spindle cells with eosinophilic cytoplasm. Targeted next-generation sequencing was performed on DNA extracted from formalin-fixed paraffin-embedded samples of the tumors. Results showed unusual epidermal growth factor receptor (EGFR) mutations, which are associated with drug resistance to EGFR tyrosine kinase inhibitors, revealing the importance of identifying morule-like features in pulmonary adenocarcinoma and the need for additional study, since there are few reported cases.

Citations

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  • Pulmonary adenocarcinoma in situ with morule - like components: A surgical case report
    Mitsuteru Yosida, Mitsuru Tomita, Naoya Kawakita, Teruki Shimizu, Ryou Yamada, Hiromitsu Takizawa, Hisanori Uehara
    Respiratory Medicine Case Reports.2024; 48: 102008.     CrossRef
  • Clinicopathological, Radiological, and Molecular Features of Primary Lung Adenocarcinoma with Morule-Like Components
    Li-Li Wang, Li Ding, Peng Zhao, Jing-Jing Guan, Xiao-Bin Ji, Xiao-Li Zhou, Shi-Hong Shao, Yu-Wei Zou, Wei-Wei Fu, Dong-Liang Lin, Dong Pan
    Disease Markers.2021; 2021: 1.     CrossRef
Brief Case Reports
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Adenocarcinoma Arising in an Ectopic Hamartomatous Thymoma with HER2 Overexpression
Harim Oh, Eojin Kim, Bokyung Ahn, Jeong Hyeon Lee, Youngseok Lee, Yang Seok Chae, Chul Hwan Kim, Yoo Jin Lee
J Pathol Transl Med. 2019;53(6):403-406.   Published online August 19, 2019
DOI: https://doi.org/10.4132/jptm.2019.06.23
  • 4,033 View
  • 115 Download
  • 2 Web of Science
  • 3 Crossref
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  • Branchioma: immunohistochemical and molecular genetic study of 23 cases highlighting frequent loss of retinoblastoma 1 immunoexpression
    Martina Bradová, Lester D. R. Thompson, Martin Hyrcza, Tomáš Vaněček, Petr Grossman, Michael Michal, Veronika Hájková, Touraj Taheri, Niels Rupp, David Suster, Sunil Lakhani, Dimitar Hadži Nikolov, Radim Žalud, Alena Skálová, Michal Michal, Abbas Agaimy
    Virchows Archiv.2024; 484(1): 103.     CrossRef
  • Adenocarcinoma arising in branchioma with a KRAS and TP53 mutation
    Natsuki Taniguchi, Akira Satou, Takanori Ito, Masato Nakaguro, Toyonori Tsuzuki
    Pathology International.2023; 73(7): 317.     CrossRef
  • Two Ectopic Hamartomatous Thymomas of Suprasternal Region of the Neck in A Single Patient: A Case Report
    Wei WANG, Manmei LONG, Zhichao WANG
    Chinese Journal of Plastic and Reconstructive Surgery.2021; 3(1): 51.     CrossRef
Human Papillomavirus–Related Multiphenotypic Sinonasal Carcinoma with Late Recurrence
Bokyung Ahn, Eojin Kim, Harim Oh, Yang-Seok Chae, Chul Hwan Kim, Youngseok Lee, Jeong Hyeon Lee, Yoo Jin Lee
J Pathol Transl Med. 2019;53(5):337-340.   Published online April 25, 2019
DOI: https://doi.org/10.4132/jptm.2019.04.02
  • 5,033 View
  • 106 Download
  • 8 Web of Science
  • 8 Crossref
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Citations

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  • HPV-Related Multiphenotypic Sinonasal Carcinoma: A Clinicoradiological Series of 3 Cases With Full Endoscopic Surgical Outcome
    Catherine Beaumont, Sylvie Nadeau, Pierre-Olivier Champagne, Michel Beauchemin, Noémie Villemure-Poliquin
    Ear, Nose & Throat Journal.2024;[Epub]     CrossRef
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    Head and Neck Pathology.2020; 14(3): 623.     CrossRef
Original Articles
Comparison of the Mismatch Repair System between Primary and Metastatic Colorectal Cancers Using Immunohistochemistry
Jiyoon Jung, Youngjin Kang, Yoo Jin Lee, Eojin Kim, Bokyung Ahn, Eunjung Lee, Joo Young Kim, Jeong Hyeon Lee, Youngseok Lee, Chul Hwan Kim, Yang-Seok Chae
J Pathol Transl Med. 2017;51(2):129-136.   Published online February 14, 2017
DOI: https://doi.org/10.4132/jptm.2016.12.09
  • 9,623 View
  • 321 Download
  • 27 Web of Science
  • 24 Crossref
AbstractAbstract PDF
Background
Colorectal cancer (CRC) is one of the most common malignancies worldwide. Approximately 10%–15% of the CRC cases have defective DNA mismatch repair (MMR) genes. Although the high level of microsatellite instability status is a predictor of favorable outcome in primary CRC, little is known about its frequency and importance in secondary CRC. Immunohistochemical staining (IHC) for MMR proteins (e.g., MLH1, MSH2, MSH6, and PMS2) has emerged as a useful technique to complement polymerase chain reaction (PCR) analyses. Methods: In this study, comparison between the MMR system of primary CRCs and paired liver and lung metastatic lesions was done using IHC and the correlation with clinical outcomes was also examined. Results: Based on IHC, 7/61 primary tumors (11.4%) showed deficient MMR systems, while 13/61 secondary tumors (21.3%) showed deficiencies. In total, 44 cases showed proficient expression in both the primary and metastatic lesions. Three cases showed deficiencies in both the primary and paired metastatic lesions. In 10 cases, proficient expression was found only in the primary lesions, and not in the corresponding metastatic lesions. In four cases, proficient expression was detected in the secondary tumor, but not in the primary tumor. Conclusions: Although each IHC result and the likely defective genes were not exactly matched between the primary and the metastatic tumors, identical results for primary and metastatic lesions were obtained in 77% of the cases (47/61). These data are in agreement with the previous microsatellite detection studies that used PCR and IHC.

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    Journal of Cancer Research and Clinical Oncology.2023; 149(7): 3423.     CrossRef
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    Charles Risbey, Timothy Fielder, Daniel Steffens, Joo‐Shik Shin, Michael Solomon
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  • Mesonephric-like Adenocarcinoma of the Uterine Corpus: Genomic and Immunohistochemical Profiling with Comprehensive Clinicopathological Analysis of 17 Consecutive Cases from a Single Institution
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    Dennis Lee Sacdalan, Reynaldo L Garcia, Michele H Diwa, Danielle Benedict Sacdalan
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    Elizabeth M. Jacobi, Gene Landon, Russell R. Broaddus, Sinchita Roy-Chowdhuri
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Does Polymerase Chain Reaction of Tissue Specimens Aid in the Diagnosis of Tuberculosis?
Yoo Jin Lee, Seojin Kim, Youngjin Kang, Jiyoon Jung, Eunjung Lee, Joo-Young Kim, Jeong Hyeon Lee, Youngseok Lee, Yang-seok Chae, Chul Hwan Kim
J Pathol Transl Med. 2016;50(6):451-458.   Published online October 10, 2016
DOI: https://doi.org/10.4132/jptm.2016.08.04
  • 9,896 View
  • 240 Download
  • 6 Web of Science
  • 9 Crossref
AbstractAbstract PDF
Background
Mycobacterial culture is the gold standard test for diagnosing tuberculosis (TB), but it is time-consuming. Polymerase chain reaction (PCR) is a highly sensitive and specific method that can reduce the time required for diagnosis. The diagnostic efficacy of PCR differs, so this study determined the actual sensitivity of TB-PCR in tissue specimens.
Methods
We retrospectively reviewed 574 cases. The results of the nested PCR of the IS6110 gene, mycobacterial culture, TB-specific antigen-induced interferon-γ release assay (IGRA), acid-fast bacilli (AFB) staining, and histological findings were evaluated.
Results
The positivity rates were 17.6% for PCR, 3.3% for the AFB stain, 22.2% for mycobacterial culture, and 55.4% for IGRA. PCR had a low sensitivity (51.1%) and a high specificity (86.3%) based on the culture results of other studies. The sensitivity was higher (65.5%) in cases with necrotizing granuloma but showed the highest sensitivity (66.7%) in those with necrosis only. The concordance rate between the methods indicated that PCR was the best method compared to mycobacterial culture, and the concordance rate increased for the methods using positive result for PCR or histologic features.
Conclusions
PCR of tissue specimens is a good alternative to detect tuberculosis, but it may not be as sensitive as previously suggested. Its reliability may also be influenced by some histological features. Our data showed a higher sensitivity when specimens contained necrosis, which indicated that only specimens with necrosis should be used for PCR to detect tuberculosis.

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Morphometric Analysis of Thyroid Follicular Cells with Atypia of Undetermined Significance
Youngjin Kang, Yoo Jin Lee, Jiyoon Jung, Youngseok Lee, Nam Hee Won, Yang Seok Chae
J Pathol Transl Med. 2016;50(4):287-293.   Published online June 13, 2016
DOI: https://doi.org/10.4132/jptm.2016.04.04
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AbstractAbstract PDF
Background
Atypia of undetermined significance (AUS) is a category that encompasses a heterogeneous group of thyroid aspiration cytology. It has been reclassified into two subgroups based on the cytomorphologic features: AUS with cytologic atypia and AUS with architectural atypia. The nuclear characteristics of AUS with cytologic atypia need to be clarified by comparing to those observed in Hashimoto thyroiditis and benign follicular lesions.
Methods
We selected 84 cases of AUS with histologic follow-up, 24 cases of Hashimoto thyroiditis, and 26 cases of benign follicular lesions. We also subcategorized the AUS group according to the follow-up biopsy results into a papillary carcinoma group and a nodular hyperplasia group. The differences in morphometric parameters, including the nuclear areas and perimeters, were compared between these groups.
Results
The AUS group had significantly smaller nuclear areas than the Hashimoto thyroiditis group, but the nuclear perimeters were not statistically different. The AUS group also had significantly smaller nuclear areas than the benign follicular lesion group; however, the AUS group had significantly longer nuclear perimeters. The nuclear areas in the papillary carcinoma group were significantly smaller than those in the nodular hyperplasia group; however, the nuclear perimeters were not statistically different.
Conclusions
We found the AUS group to be a heterogeneous entity, including histologic follow-up diagnoses of papillary carcinoma and nodular hyperplasia. The AUS group showed significantly greater nuclear irregularities than the other two groups. Utilizing these features, nuclear morphometry could lead to improvements in the accuracy of the subjective diagnoses made with thyroid aspiration cytology.

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Brief Case Report
Intramuscular Tenosynovial Giant Cell Tumor, Diffuse-Type
Yoo Jin Lee, Youngjin Kang, Jiyoon Jung, Seojin Kim, Chul Hwan Kim
J Pathol Transl Med. 2016;50(4):306-308.   Published online January 11, 2016
DOI: https://doi.org/10.4132/jptm.2015.11.15
  • 8,399 View
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PDF

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  • Limited usefulness of classic MR findings in the diagnosis of tenosynovial giant cell tumor
    Julia Crim, Samantha L Dyroff, James Derek Stensby, Andrea Evenski, Lester J Layfield
    Skeletal Radiology.2021; 50(8): 1585.     CrossRef
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