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A standardized pathology report for gastric cancer: 2nd edition
Young Soo Park, Myeong-Cherl Kook, Baek-hui Kim, Hye Seung Lee, Dong-Wook Kang, Mi-Jin Gu, Ok Ran Shin, Younghee Choi, Wonae Lee, Hyunki Kim, In Hye Song, Kyoung-Mee Kim, Hee Sung Kim, Guhyun Kang, Do Youn Park, So-Young Jin, Joon Mee Kim, Yoon Jung Choi, Hee Kyung Chang, Soomin Ahn, Mee Soo Chang, Song-Hee Han, Yoonjin Kwak, An Na Seo, Sung Hak Lee, Mee-Yon Cho
J Pathol Transl Med. 2023;57(1):1-27.   Published online January 15, 2023
  • 1,097 View
  • 232 Download
AbstractAbstract PDFSupplementary Material
The first edition of ‘A Standardized Pathology Report for Gastric Cancer’ was initiated by the Gastrointestinal Pathology Study Group of the Korean Society of Pathologists and published 17 years ago. Since then, significant advances have been made in the pathologic diagnosis, molecular genetics, and management of gastric cancer (GC). To reflect those changes, a committee for publishing a second edition of the report was formed within the Gastrointestinal Pathology Study Group of the Korean Society of Pathologists. This second edition consists of two parts: standard data elements and conditional data elements. The standard data elements contain the basic pathologic findings and items necessary to predict the prognosis of GC patients, and they are adequate for routine surgical pathology service. Other diagnostic and prognostic factors relevant to adjuvant therapy, including molecular biomarkers, are classified as conditional data elements to allow each pathologist to selectively choose items appropriate to the environment in their institution. We trust that the standardized pathology report will be helpful for GC diagnosis and facilitate large-scale multidisciplinary collaborative studies.
Original Articles
Extremely well-differentiated adenocarcinoma of the stomach: diagnostic pitfalls in endoscopic biopsy
Jongwon Lee, In-Seob Lee, Ji Yong Ahn, Young Soo Park, Jihun Kim
J Pathol Transl Med. 2022;56(2):63-72.   Published online November 16, 2021
  • 3,379 View
  • 325 Download
AbstractAbstract PDFSupplementary Material
Extremely well-differentiated adenocarcinoma (EWDA) is a deceptively bland-looking adenocarcinoma of the stomach. It often causes diagnostic problems, especially in endoscopic biopsy samples. To better recognize this deceptively bland lesion, we carefully reviewed a series of EWDAs treated at our institution.
A total of 55 specimens from 19 patients were obtained. Endoscopic, gross and microscopic features defining EWDA were described and documented. For comparison, hyperplastic polyp specimens were randomly selected and analyzed.
Most cases (18 of 19, 94.7%) were advanced gastric cancer (AGC) and primarily located in the body of the stomach (15 of 19, 79.0%). The majority of AGCs were non-ulcerated (11 of 18, 61.1%) with an undermining growth pattern and a relatively small mucosal involvement. Specific histologic features included an irregular glandular shape, an undulating apical cytoplasmic border, disproportionately large glands, a variably distended mucinous cytoplasm. Classical features, such as small infiltrating glands or desmoplastic reactions, were barely observed. Identification of irregularly spaced nuclei and disruption of the foveolar epithelial structure, along with atypical features described above were helpful in making a diagnosis especially in gastric forceps biopsies.
Awareness of the histomorphologic characteristics described in this report would lead to timely diagnosis and prevent repeated endoscopic procedures.
Expression of CD99 in Multiple Myeloma: A Clinicopathologic and Immunohistochemical Study of 170 Cases
Su-Jin Shin, Hyangsin Lee, Geunyoung Jung, Minchan Gil, Hosub Park, Young Soo Park, Dok Hyun Yoon, Cheolwon Suh, Chan-Jeoung Park, Jooryung Huh, Chan-Sik Park
Korean J Pathol. 2014;48(3):209-216.   Published online June 26, 2014
  • 6,742 View
  • 53 Download
  • 8 Citations
AbstractAbstract PDF

Multiple myeloma (MM) is a heterogeneous and ultimately fatal disease. Risk stratification using prognostic biomarkers is crucial to individualize treatments. We sought to investigate the role of CD99, a transmembrane protein highly expressed in many hematopoietic cells including subpopulations of normal and neoplastic plasma cells, for MM risk stratification.


CD99 expression was measured in paraffin samples of bone marrow and extramedullary biopsies of 170 patients with MM. Patients were divided into those with high score (moderately and strongly positive) and low score (negative and weakly positive), with all staining being cytoplasmic and/or membranous.


High anti-CD99 immunostaining was observed in 72 of 136 (52.9%) bone marrow biopsies and 24 of 87 (27.6%) extramedullary biopsies in MM. High CD99 expression of extramedullary specimens was associated with significantly longer overall survival (OS; p=.016). High CD99 expression of extramedullary specimens was also associated with better prognosis in the nonautologous stem cell transplantation group of MM patients (p=.044). In multivariate analysis, International Staging System stage was an independent prognostic factor, whereas CD99 expression was no longer statistically significant.


Expression of CD99 in extramedullary specimens was correlated with longer OS, suggesting that CD99 may be a helpful immunohistochemical marker for risk stratification.


Citations to this article as recorded by  
  • Detection of Circulating Tumor Plasma Cells in Monoclonal Gammopathies: Methods, Pathogenic Role, and Clinical Implications
    Luzalba Sanoja-Flores, Juan Flores-Montero, Martín Pérez-Andrés, Noemí Puig, Alberto Orfao
    Cancers.2020; 12(6): 1499.     CrossRef
  • Tumor suppressor CD99 is downregulated in plasma cell neoplasms lacking CCND1 translocation and distinguishes neoplastic from normal plasma cells and B-cell lymphomas with plasmacytic differentiation from primary plasma cell neoplasms
    Qi Gao, Venkata Yellapantula, Maly Fenelus, Janine Pichardo, Lu Wang, Ola Landgren, Ahmet Dogan, Mikhail Roshal
    Modern Pathology.2018; 31(6): 881.     CrossRef
  • EWSR1 fusion proteins mediate PAX7 expression in Ewing sarcoma
    Gregory W Charville, Wei-Lien Wang, Davis R Ingram, Angshumoy Roy, Dafydd Thomas, Rajiv M Patel, Jason L Hornick, Matt van de Rijn, Alexander J Lazar
    Modern Pathology.2017; 30(9): 1312.     CrossRef
  • Activation of the polycomb repressive complex pathway in the bone marrow resident cells of diffuse large B-cell lymphoma patients
    Eun Ji Oh, Eun Kyung Kim, Woo Ick Yang, Sun Och Yoon
    Leukemia & Lymphoma.2016; 57(8): 1921.     CrossRef
  • CD99 Is Strongly Expressed in Basal Cells of the Normal Adult Epidermis and Some Subpopulations of Appendages: Comparison with Developing Fetal Skin
    Gawon Choi, Jin Roh, Chan-Sik Park
    Journal of Pathology and Translational Medicine.2016; 50(5): 361.     CrossRef
  • Towards Stratified Medicine in Plasma Cell Myeloma
    Philip Egan, Stephen Drain, Caroline Conway, Anthony Bjourson, H. Alexander
    International Journal of Molecular Sciences.2016; 17(10): 1760.     CrossRef
  • Human Myeloma Cell Lines Induce Osteoblast Downregulation of CD99 Which Is Involved in Osteoblast Formation and Activity
    Angela Oranger, Giacomina Brunetti, Claudia Carbone, Graziana Colaianni, Teresa Mongelli, Isabella Gigante, Roberto Tamma, Giorgio Mori, Adriana Di Benedetto, Marika Sciandra, Selena Ventura, Katia Scotlandi, Silvia Colucci, Maria Grano
    Journal of Immunology Research.2015; 2015: 1.     CrossRef
  • CD99 regulates CXCL12-induced chemotaxis of human plasma cells
    Minchan Gil, Hyo-Kyung Pak, A-Neum Lee, Seo-Jung Park, Yoonkyung Lee, Jin Roh, Hyunji Lee, Yoo-Sam Chung, Chan-Sik Park
    Immunology Letters.2015; 168(2): 329.     CrossRef
Brief Case Report
Adenocarcinoma Arising in Gastric Duplication Cyst
Hyo Jeong Kang, Se Jin Jang, Young Soo Park
Korean J Pathol. 2014;48(2):159-161.   Published online April 28, 2014
  • 5,962 View
  • 42 Download
  • 7 Citations


Citations to this article as recorded by  
  • Clinical features of gastric duplications: evidence from primary case reports and published data
    Yang Li, Chen Li, Hao Wu, Quan Wang, Zhi-Dong Gao, Xiao-Dong Yang, Ke-Wei Jiang, Ying-Jiang Ye
    Orphanet Journal of Rare Diseases.2021;[Epub]     CrossRef
  • Sarcomatoid Carcinoma Arising in a Gastric Duplication Cyst
    Mohamed A. H. Ahmed, Kanchana Sanjeewani Liyanaarachchi, Shaun R. Preston, Madeleine Hewish, Izhar N. Bagwan
    ACG Case Reports Journal.2021; 8(5): e00584.     CrossRef
  • Pancreatobiliary Adenocarcinoma in a Gastric Duplication Cyst: A Doubly Rare Diagnosis
    Ana Rolo, Rui Caetano Oliveira, Bárbara Lima, Ana Barbosa, Ilda Faustino
    Cureus.2021;[Epub]     CrossRef
  • Adenocarcinoma Arising From a Gastric Duplication Cyst With Lymph Node Metastasis
    Shoichi Kinugasa, Hiroyuki Monma, Yoshio Sakamoto, Takafumi Watanabe, Masayo Fujimoto
    Cureus.2020;[Epub]     CrossRef
  • Adult Gastric Bronchogenic Cyst With Elevated Tumor Marker in Containing Fluid: A Case Report and Literature Review
    Jixuan Duan, Sheng Yan, Qiyi Zhang, Jingjin Wu, Yu Du, K. G Owusu-Ansah, Shusen Zheng
    International Surgery.2019; 104(1-2): 58.     CrossRef
  • Papillary Adenocarcinoma in a Gastric Duplication Cyst
    Sonali Sethi, Satyajit Godhi, Sunil Kumar Puri
    Indian Journal of Surgical Oncology.2018; 9(1): 79.     CrossRef
  • Non-communicating gastric duplication cyst in a 10-week-old Labrador Retriever puppy
    MW Jack, D Burgess, A Griffin
    Australian Veterinary Journal.2016; 94(5): 166.     CrossRef
Original Article
Expression Pattern of the Cortical Immature Thymocyte Specific Antigen JL1 in Thymomas; a New Adjunctive Diagnostic Marker.
Young Soo Park, Youngji Kim, Yun Hee Lee, Joo Ryung Huh, Chan Sik Park
Korean J Pathol. 2008;42(5):251-259.
  • 1,513 View
  • 14 Download
AbstractAbstract PDF
JL1 is a novel antigen that has been reported to be expressed exclusively in immature CD4 CD8 double positive T-cells in the thymic cortex. Thymomas are often infiltrated with lymphocytes that are mostly immature T-cells. METHODS: We evaluated 67 cases of surgically resected thymomas and reviewed their histological, surgical, and clinical findings. Representative sections were immunostained using anti-JL1 monoclonal antibody and the immunostaining score was evaluated in each case. RESULTS: JL1 was strongly positive in immature T cells infiltrated in various subtypes of thymomas. The mean value of the immunostaining score was 0 for type A, 0.24 for the A areas of type AB, 2.71 for the B areas of type AB, 3 for type B1, 1.87 for type B2, 0.67 for type B3, and 0.13 for type C. The immunostaining score correlated with the histological subtypes according to the WHO classification, and stages according to the modified Masaoka system. CONCLUSION: JL1 was specifically detected in immature thymocytes in thymomas. Therefore, JL1 immunostaining can be useful for subtyping thymomas. JL1 can also serve as an adjunctive marker to diagnose thymomas in small biopsy specimens.

JPTM : Journal of Pathology and Translational Medicine