Journal of Pathology and Translational Medicine

Eunjung Lee

7 Articles

Comparison of the Mismatch Repair System between Primary and Metastatic Colorectal Cancers Using Immunohistochemistry: Jiyoon Jung, Youngjin Kang, Yoo Jin Lee, Eojin Kim, Bokyung Ahn, Eunjung Lee, Joo Young Kim, Jeong Hyeon Lee, Youngseok Lee, Chul Hwan Kim, Yang-Seok Chae; J Pathol Transl Med. 2017;51(2):129-136. Published online February 14, 2017; DOI: https://doi.org/10.4132/jptm.2016.12.09

10,507 View
323 Download
28 Web of Science
26 Crossref

Background
Colorectal cancer (CRC) is one of the most common malignancies worldwide. Approximately 10%–15% of the CRC cases have defective DNA mismatch repair (MMR) genes. Although the high level of microsatellite instability status is a predictor of favorable outcome in primary CRC, little is known about its frequency and importance in secondary CRC. Immunohistochemical staining (IHC) for MMR proteins (e.g., MLH1, MSH2, MSH6, and PMS2) has emerged as a useful technique to complement polymerase chain reaction (PCR) analyses. Methods: In this study, comparison between the MMR system of primary CRCs and paired liver and lung metastatic lesions was done using IHC and the correlation with clinical outcomes was also examined. Results: Based on IHC, 7/61 primary tumors (11.4%) showed deficient MMR systems, while 13/61 secondary tumors (21.3%) showed deficiencies. In total, 44 cases showed proficient expression in both the primary and metastatic lesions. Three cases showed deficiencies in both the primary and paired metastatic lesions. In 10 cases, proficient expression was found only in the primary lesions, and not in the corresponding metastatic lesions. In four cases, proficient expression was detected in the secondary tumor, but not in the primary tumor. Conclusions: Although each IHC result and the likely defective genes were not exactly matched between the primary and the metastatic tumors, identical results for primary and metastatic lesions were obtained in 77% of the cases (47/61). These data are in agreement with the previous microsatellite detection studies that used PCR and IHC.

Citations

Citations to this article as recorded by

Immunotherapy-induced microsatellite instability status shift in recurrent perihilar cholangiocarcinoma: A case report
Hailing Yu, Tan Deng, Hongbing Liu
Human Vaccines & Immunotherapeutics.2025;[Epub] CrossRef
Prognostic and predictive value of microsatellite instability analysis in ctDNA by digital droplet PCR for patients with MSI colorectal cancers.
Camille Evrard, Tristan Rochelle, Marine Martel, Anis Al Achkar, Aurélie Ferru, Violaine Randrian, Lucie Karayan-Tapon, David Tougeron
Laboratory Investigation.2025; : 104176. CrossRef
MMR profile and microsatellite instability status in colorectal mucinous adenocarcinoma with synchronous metastasis: a new clue for the clinical practice
Paola Parente, Umberto Malapelle, Valentina Angerilli, Mariangela Balistreri, Sara Lonardi, Salvatore Pucciarelli, Caterina De Luca, Francesco Pepe, Gianluca Russo, Elena Vigliar, Angela Danza, Fabio Scaramuzzi, Giancarlo Troncone, Paolo Graziano, Matteo
Journal of Clinical Pathology.2023; 76(7): 492. CrossRef
Histomorphological and molecular genetic characterization of different intratumoral regions and matched metastatic lymph nodes of colorectal cancer with heterogenous mismatch repair protein expression
Jing Zhang, Xin Zhang, Qian Wang, Yu-yin Xu, Qian-lan Yao, Dan Huang, Wei-qi Sheng, Xiao-li Zhu, Xiao-yan Zhou, Qian-ming Bai
Journal of Cancer Research and Clinical Oncology.2023; 149(7): 3423. CrossRef
Intraindividual Tumor Heterogeneity of Mismatch Repair Status in Metastatic Colorectal Cancer
Qianpeng Huang, Tao Yu, Lei Li, Qi Zhang, Shiyao Zhang, Baosong Li, Xiaoping Li, Wanyi Xiao, Gang Liu
Applied Immunohistochemistry & Molecular Morphology.2023; 31(2): 84. CrossRef
Patterns of DNA mismatch repair protein expression for primary and recurrent colorectal cancer at an advanced surgical unit: A retrospective audit
Charles Risbey, Timothy Fielder, Daniel Steffens, Joo‐Shik Shin, Michael Solomon
Colorectal Disease.2023; 25(3): 369. CrossRef
Mesonephric-like Adenocarcinoma of the Uterine Corpus: Genomic and Immunohistochemical Profiling with Comprehensive Clinicopathological Analysis of 17 Consecutive Cases from a Single Institution
Hyun-Hee Koh, Eunhyang Park, Hyun-Soo Kim
Biomedicines.2023; 11(8): 2269. CrossRef
Multilevel Heterogeneity of Colorectal Cancer Liver Metastasis
Hao Chen, Chongya Zhai, Xian Xu, Haidong Wang, Weidong Han, Jiaying Shen
Cancers.2023; 16(1): 59. CrossRef
Heterogeneity of Mismatch Repair Status and Microsatellite Instability between Primary Tumour and Metastasis and Its Implications for Immunotherapy in Colorectal Cancers
Camille Evrard, Stéphane Messina, David Sefrioui, Éric Frouin, Marie-Luce Auriault, Romain Chautard, Aziz Zaanan, Marion Jaffrelot, Christelle De La Fouchardière, Thomas Aparicio, Romain Coriat, Julie Godet, Christine Silvain, Violaine Randrian, Jean-Chri
International Journal of Molecular Sciences.2022; 23(8): 4427. CrossRef
Clinicopathologic Factors Associated with Mismatch Repair Status Among Filipino Patients with Young-Onset Colorectal Cancer
Dennis Lee Sacdalan, Reynaldo L Garcia, Michele H Diwa, Danielle Benedict Sacdalan
Cancer Management and Research.2021; Volume 13: 2105. CrossRef
Recommendations for Specimen and Therapy Selection in Colorectal Cancer
Snehal B. Patel, Robert Bookstein, Navid Farahani, Myriam Chevarie-Davis, Andy Pao, Angela Aguiluz, Christian Riley, Jennelle C. Hodge, Serhan Alkan, Zhenqui Liu, Nan Deng, Jean R. Lopategui
Oncology and Therapy.2021; 9(2): 451. CrossRef
Evaluating Mismatch Repair/Microsatellite Instability Status Using Cytology Effusion Specimens to Determine Eligibility for Immunotherapy
Elizabeth M. Jacobi, Gene Landon, Russell R. Broaddus, Sinchita Roy-Chowdhuri
Archives of Pathology & Laboratory Medicine.2021; 145(1): 46. CrossRef
Médecine de précision et immunoradiothérapie
C. Chargari, C. Robert, C. Genestie, E. Deutsch
Cancer/Radiothérapie.2021; 25(6-7): 570. CrossRef
Identificación del fenotipo de inestabilidad microsatelital en carcinoma colorrectal mediante el análisis de la expresión de proteínas reparadoras del ADN: Revisión narrativa
Orlando Rodas-Pernillo, Edith Oregón
Ciencia, Tecnología y Salud.2021; 8(2): 232. CrossRef
Japan Society of Clinical Oncology provisional clinical opinion for the diagnosis and use of immunotherapy in patients with deficient DNA mismatch repair tumors, cooperated by Japanese Society of Medical Oncology, First Edition
Saori Mishima, Hiroya Taniguchi, Kiwamu Akagi, Eishi Baba, Yutaka Fujiwara, Akira Hirasawa, Masafumi Ikeda, Osamu Maeda, Kei Muro, Hiroshi Nishihara, Hiroyki Nishiyama, Tadao Takano, Katsuya Tsuchihara, Yasushi Yatabe, Yasuhiro Kodera, Takayuki Yoshino
International Journal of Clinical Oncology.2020; 25(2): 217. CrossRef
Microsatellite Stable Colorectal Cancer With an Immunogenic Phenotype: Challenges in Diagnosis and Treatment
James Saller, Dahui Qin, Seth Felder, Domenico Coppola
Clinical Colorectal Cancer.2020; 19(2): 123. CrossRef
Should you repeat mismatch repair testing in cases of tumour recurrence? An evaluation of repeat mismatch repair testing by the use of immunohistochemistry in recurrent tumours of the gastrointestinal and gynaecological tracts
John J Aird, Michael J Steel, Christine Chow, Julie Ho, Robert Wolber, C Blake Gilks, Lynn N Hoang, David F Schaeffer
Histopathology.2020; 76(4): 521. CrossRef
Microsatellite instability as a unique characteristic of tumors and a predictor of response to immune therapy
A. A. Tryakin, M. Yu. Fedyanin, A. S. Tsukanov, Yu. A. Shelygin, I. A. Pokataev, E. O. Ignatova, G. G. Khakimova, M. A. Frolova, S. A. Tjulandin
Malignant tumours.2020; 9(4): 59. CrossRef
Spontaneous regression of transverse colon cancer with high-frequency microsatellite instability: a case report and literature review
Nozomi Karakuchi, Manabu Shimomura, Kazuhiro Toyota, Takao Hinoi, Hideki Yamamoto, Seiji Sadamoto, Koichi Mandai, Hiroyuki Egi, Hideki Ohdan, Tadateru Takahashi
World Journal of Surgical Oncology.2019;[Epub] CrossRef
Biomarker concordance between primary colorectal cancer and its metastases
D.S. Bhullar, J. Barriuso, S. Mullamitha, M.P. Saunders, S.T. O'Dwyer, O. Aziz
EBioMedicine.2019; 40: 363. CrossRef
Identification of novel pathogenic MSH2 mutation and new DNA repair genes variants: investigation of a Tunisian Lynch syndrome family with discordant twins
Amira Jaballah-Gabteni, Haifa Tounsi, Maria Kabbage, Yosr Hamdi, Sahar Elouej, Ines Ben Ayed, Mouna Medhioub, Moufida Mahmoudi, Hamza Dallali, Hamza Yaiche, Nadia Ben Jemii, Afifa Maaloul, Najla Mezghani, Sonia Abdelhak, Lamine Hamzaoui, Mousaddak Azzouz,
Journal of Translational Medicine.2019;[Epub] CrossRef
Mismatch repair status between primary colorectal tumor and metastatic tumor, a retrospective consistent study
Zheng Wang, Xiaoli Tang, Xiaoqing Wu, Meiyuan Yang, Daorong Wang
Bioscience Reports.2019;[Epub] CrossRef
Heterogeneity of mismatch repair defect in colorectal cancer and its implications in clinical practice
Gaelle Tachon, Eric Frouin, Lucie Karayan-Tapon, Marie-Luce Auriault, Julie Godet, Valerie Moulin, Qing Wang, David Tougeron
European Journal of Cancer.2018; 95: 112. CrossRef
DNA mismatch repair in cancer
Marina Baretti, Dung T. Le
Pharmacology & Therapeutics.2018; 189: 45. CrossRef
Discordant loss of mismatch repair proteins in advanced endometrial endometrioid carcinoma compared to paired primary uterine tumors
Robert M. Ta, Jonathan L. Hecht, Douglas I. Lin
Gynecologic Oncology.2018; 151(3): 401. CrossRef
The CpG island methylator phenotype is concordant between primary colorectal carcinoma and matched distant metastases
Stacey A. Cohen, Ming Yu, Kelsey Baker, Mary Redman, Chen Wu, Tai J. Heinzerling, Ralph M. Wirtz, Elpida Charalambous, George Pentheroudakis, Vassiliki Kotoula, Konstantine T. Kalogeras, George Fountzilas, William M. Grady
Clinical Epigenetics.2017;[Epub] CrossRef

Does Polymerase Chain Reaction of Tissue Specimens Aid in the Diagnosis of Tuberculosis?: Yoo Jin Lee, Seojin Kim, Youngjin Kang, Jiyoon Jung, Eunjung Lee, Joo-Young Kim, Jeong Hyeon Lee, Youngseok Lee, Yang-seok Chae, Chul Hwan Kim; J Pathol Transl Med. 2016;50(6):451-458. Published online October 10, 2016; DOI: https://doi.org/10.4132/jptm.2016.08.04

11,054 View
243 Download
6 Web of Science
9 Crossref

Abstract PDF

Background
Mycobacterial culture is the gold standard test for diagnosing tuberculosis (TB), but it is time-consuming. Polymerase chain reaction (PCR) is a highly sensitive and specific method that can reduce the time required for diagnosis. The diagnostic efficacy of PCR differs, so this study determined the actual sensitivity of TB-PCR in tissue specimens.
Methods
We retrospectively reviewed 574 cases. The results of the nested PCR of the IS6110 gene, mycobacterial culture, TB-specific antigen-induced interferon-γ release assay (IGRA), acid-fast bacilli (AFB) staining, and histological findings were evaluated.
Results
The positivity rates were 17.6% for PCR, 3.3% for the AFB stain, 22.2% for mycobacterial culture, and 55.4% for IGRA. PCR had a low sensitivity (51.1%) and a high specificity (86.3%) based on the culture results of other studies. The sensitivity was higher (65.5%) in cases with necrotizing granuloma but showed the highest sensitivity (66.7%) in those with necrosis only. The concordance rate between the methods indicated that PCR was the best method compared to mycobacterial culture, and the concordance rate increased for the methods using positive result for PCR or histologic features.
Conclusions
PCR of tissue specimens is a good alternative to detect tuberculosis, but it may not be as sensitive as previously suggested. Its reliability may also be influenced by some histological features. Our data showed a higher sensitivity when specimens contained necrosis, which indicated that only specimens with necrosis should be used for PCR to detect tuberculosis.

Citations

Citations to this article as recorded by

The Need for Persistence in the Diagnosis of Mycobacterium Tuberculosis Mono-arthritis: A Unique Case Presentation
T. Bekoulis, P. Christodoulou, K. Dogramatzis, E. Markopoulou, Emmanouel Antonogiannakis, E. Kokkinakis, Alexandros P. Apostolopoulos, A. Manimanaki
Journal of Long-Term Effects of Medical Implants.2024; 34(1): 35. CrossRef
A Case Report on Scrofuloderma: A Cutaneous Manifestation of Tuberculosis
Soham R Meghe, Adarshlata Singh, Drishti M Bhatt, Shreya N Gupta, Varun Hanumanthaiah, Shree Ramya Talasila
Cureus.2024;[Epub] CrossRef
An overview of infectious disease laboratory methods: an update for the histopathologist
Daniel R. Stevenson
Diagnostic Histopathology.2024; 30(10): 534. CrossRef
Diagnostic Utility of Biplex/Multiplex Polymerase Chain Reaction in Infectious Granulomatous Dermatitis in North Indian Population
Mayur Parkhi, Mukin Kumar S, Dipankar De, Rakesh Yadav, Sunil Sethi, Bishan Dass Radotra, Uma Nahar Saikia
The American Journal of Dermatopathology.2021; 43(8): 567. CrossRef
Reduction of turnaround time for non-tuberculous mycobacteria detection in heater–cooler units by propidium monoazide–real-time polymerase chain reaction
S. Ditommaso, M. Giacomuzzi, G. Memoli, R. Cavallo, A. Curtoni, M. Avolio, C. Silvestre, C.M. Zotti
Journal of Hospital Infection.2020; 104(3): 365. CrossRef
Ergonomic Diagnostic Tool based on Chip Mini RT-PCR for Diagnosis of Pulmonary and Extra Pulmonary Tuberculosis
V Mangayarkarasi, Sneka P, Sujith R, Jayaprakash Jayaprakash
Journal of Pure and Applied Microbiology.2019; 13(2): 1185. CrossRef
Cutaneous Tuberculosis: Clinicopathologic Arrays and Diagnostic Challenges
Priyatam Khadka, Soniya Koirala, Januka Thapaliya
Dermatology Research and Practice.2018; 2018: 1. CrossRef
Utility of Real-Time Quantitative Polymerase Chain Reaction in DetectingMycobacterium tuberculosis
Zhongquan Lv, Mingxin Zhang, Hui Zhang, Xinxin Lu
BioMed Research International.2017; 2017: 1. CrossRef
Primary Appendicular Tuberculosis
Vipul D Yagnik
Gastroenterology & Hepatology: Open Access.2017;[Epub] CrossRef

SIRT7, H3K18ac, and ELK4 Immunohistochemical Expression in Hepatocellular Carcinoma: Hye Seung Lee, Wonkyung Jung, Eunjung Lee, Hyeyoon Chang, Jin Hyuk Choi, Han Gyeom Kim, Aeree Kim, Baek-hui Kim; J Pathol Transl Med. 2016;50(5):337-344. Published online August 5, 2016; DOI: https://doi.org/10.4132/jptm.2016.05.20

10,970 View
167 Download
27 Web of Science
27 Crossref

Abstract PDF

Background
SIRT7 is one of the histone deacetylases and is NAD-dependent. It forms a complex with ETS-like transcription factor 4 (ELK4), which deacetylates H3K18ac and works as a transcriptional suppressor. Overexpression of SIRT7 and deacetylation of H3K18ac have been shown to be associated with aggressive clinical behavior in some cancers, including hepatocellular carcinoma (HCC). The present study investigated the immunohistochemical expression of SIRT7, H3K18ac, and ELK4 in hepatocellular carcinoma.
Methods
A total of 278 HCC patients were enrolled in this study. Tissue microarray blocks were made from existing paraffin-embedded blocks. Immunohistochemical expressions of SIRT7, H3K18ac and ELK4 were scored and analyzed.
Results
High SIRT7 (p = .034), high H3K18ac (p = .001), and low ELK4 (p = .021) groups were associated with poor outcomes. Age < 65 years (p = .028), tumor size ≥ 5 cm (p = .001), presence of vascular emboli (p = .003), involvement of surgical margin (p = .001), and high American Joint Committee on Cancer stage (III&V) (p < .001) were correlated with worse prognoses. In multivariate analysis, H3K18ac (p = .001) and ELK4 (p = .015) were the significant independent prognostic factors.
Conclusions
High SIRT7 expression with poor overall survival implies that deacetylation of H3K18ac contributes to progression of HCC. High H3K18ac expression with poor prognosis is predicted due to a compensation mechanism. In addition, high ELK4 expression with good prognosis suggests another role of ELK4 as a tumor suppressor beyond SIRT7’s helper. In conclusion, we could assume that the H3K18ac deacetylation pathway is influenced by many other factors.

Citations

Citations to this article as recorded by

Combined single-cell RNA sequencing and mendelian randomization to identify biomarkers associated with necrotic apoptosis in intervertebral disc degeneration
Yi Ye, Lun Wan, Jiang Hu, Xiaoxue Li, Kun Zhang
The Spine Journal.2025; 25(1): 165. CrossRef
ETS-1 in tumor immunology: implications for novel anti-cancer strategies
SiYu Wang, Lei Wan, XiaoJun Zhang, HaoXiang Fang, MengYu Zhang, Feng Li, DaWei Yan
Frontiers in Immunology.2025;[Epub] CrossRef
Role of SIRT7 in Prostate Cancer Progression: New Insight Into Potential Therapeutic Target
Jiale Zhang, Chenxin Liu, Wenting Luo, Baoqing Sun
Cancer Medicine.2025;[Epub] CrossRef
SIRT7: the seventh key to unlocking the mystery of aging
Umar Raza, Xiaolong Tang, Zuojun Liu, Baohua Liu
Physiological Reviews.2024; 104(1): 253. CrossRef
The Significance of Modified Histone H3 in Epithelial Dysplasia and Oral Cancer
Woraphaluck Tachaveeraphong, Ekarat Phattarataratip
International Dental Journal.2024; 74(4): 769. CrossRef
Analysis of the Expression and Prognostic Value of SIRTs in Hepatocellular Carcinoma
Chuang Qin, Xiaofei Ye, Hongliang Luo, Hu Jin, Qiang Liu, Jiangfa Li
International Journal of General Medicine.2024; Volume 17: 2655. CrossRef
Role of Sirtuins in the Pathogenesis of Rheumatoid Arthritis
Agata Poniewierska-Baran, Oliwia Bochniak, Paulina Warias, Andrzej Pawlik
International Journal of Molecular Sciences.2023; 24(2): 1532. CrossRef
Role of sirtuins in hepatocellular carcinoma progression and multidrug resistance: Mechanistical and pharmacological perspectives
María Paula Ceballos, Ariel Darío Quiroga, Nicolás Francisco Palma
Biochemical Pharmacology.2023; 212: 115573. CrossRef
Substrates and Cyclic Peptide Inhibitors of the Oligonucleotide‐Activated Sirtuin 7**
Julie E. Bolding, Alexander L. Nielsen, Iben Jensen, Tobias N. Hansen, Line A. Ryberg, Samuel T. Jameson, Pernille Harris, Günther H. J. Peters, John M. Denu, Joseph M. Rogers, Christian A. Olsen
Angewandte Chemie International Edition.2023;[Epub] CrossRef
Substrates and Cyclic Peptide Inhibitors of the Oligonucleotide‐Activated Sirtuin 7**
Julie E. Bolding, Alexander L. Nielsen, Iben Jensen, Tobias N. Hansen, Line A. Ryberg, Samuel T. Jameson, Pernille Harris, Günther H. J. Peters, John M. Denu, Joseph M. Rogers, Christian A. Olsen
Angewandte Chemie.2023;[Epub] CrossRef
Epigenomic interplay in tumor heterogeneity: Potential of epidrugs as adjunct therapy
Suvasmita Rath, Diptesh Chakraborty, Jyotsnarani Pradhan, Mohammad Imran Khan, Jagneshwar Dandapat
Cytokine.2022; 157: 155967. CrossRef
Distinct histone H3 modification profiles correlate with aggressive characteristics of salivary gland neoplasms
Aroonwan Lam-Ubol, Ekarat Phattarataratip
Scientific Reports.2022;[Epub] CrossRef
Acetyl-CoA: An interplay between metabolism and epigenetics in cancer
Yang Hao, Qin Yi, Xu XiaoWu, Chen WeiBo, Zu GuangChen, Chen XueMin
Frontiers in Molecular Medicine.2022;[Epub] CrossRef
Sirtuins (SIRTs) As a Novel Target in Gastric Cancer
Agata Poniewierska-Baran, Paulina Warias, Katarzyna Zgutka
International Journal of Molecular Sciences.2022; 23(23): 15119. CrossRef
Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma
Fang Wang, Peter Breslin S J, Wei Qiu
Liver Research.2021; 5(4): 195. CrossRef
Acute high folic acid treatment in SH-SY5Y cells with and without MTHFR function leads to gene expression changes in epigenetic modifying enzymes, changes in epigenetic marks, and changes in dendritic spine densities
Daniel F. Clark, Rachael Schmelz, Nicole Rogers, Nuri E. Smith, Kimberly R. Shorter, Lorenzo Chiariotti
PLOS ONE.2021; 16(1): e0245005. CrossRef
The E-Twenty-Six Family in Hepatocellular Carcinoma: Moving into the Spotlight
Tongyue Zhang, Danfei Liu, Yijun Wang, Mengyu Sun, Limin Xia
Frontiers in Oncology.2021;[Epub] CrossRef
Upregulation of histone acetylation reverses organic anion transporter 2 repression and enhances 5-fluorouracil sensitivity in hepatocellular carcinoma
Yingying Wang, Qianying Zhu, Haihong Hu, Hong Zhu, Bo Yang, Qiaojun He, Lushan Yu, Su Zeng
Biochemical Pharmacology.2021; 188: 114546. CrossRef
HCG11 up-regulation induced by ELK4 suppressed proliferation in vestibular schwannoma by targeting miR-620/ELK4
Ruiqing Long, Zhuohui Liu, Jinghui Li, Yuan Zhang, Hualin Yu
Cancer Cell International.2021;[Epub] CrossRef
Downregulation of circular RNA circPVT1 restricts cell growth of hepatocellular carcinoma through downregulation of Sirtuin 7 via microRNA‐3666
Yong Li, Haitao Shi, Jia Yuan, Lu Qiao, Lei Dong, Yan Wang
Clinical and Experimental Pharmacology and Physiology.2020; 47(7): 1291. CrossRef
Clinicopathological and molecular analysis of SIRT7 in hepatocellular carcinoma
Masae Yanai, Morito Kurata, Yutaka Muto, Hiroto Iha, Toshinori Kanao, Anna Tatsuzawa, Sachiko Ishibashi, Masumi Ikeda, Masanobu Kitagawa, Kouhei Yamamoto
Pathology.2020; 52(5): 529. CrossRef
MicroRNA‐148b Inhibits the Malignant Biological Behavior of Melanoma by Reducing Sirtuin 7 Expression Levels
Rui Sun, Meiliang Guo, Xiaojing Fan, Qinqin Meng, Dingfen Yuan, Xinrong Yang, Kexiang Yan, Hui Deng, Fengjie Sun
BioMed Research International.2020;[Epub] CrossRef
H3K18Ac as a Marker of Cancer Progression and Potential Target of Anti-Cancer Therapy
Marta Hałasa, Anna Wawruszak, Alicja Przybyszewska, Anna Jaruga, Małgorzata Guz, Joanna Kałafut, Andrzej Stepulak, Marek Cybulski
Cells.2019; 8(5): 485. CrossRef
Sirtuin7 has an oncogenic potential via promoting the growth of cholangiocarcinoma cells
Wenzhi Li, Zhe Sun, Chen Chen, Lin Wang, Zhimin Geng, Jie Tao
Biomedicine & Pharmacotherapy.2018; 100: 257. CrossRef
Identification of cancer‐related potential biomarkers based on lncRNA–pseudogene–mRNA competitive networks
Cheng Wu, Yunzhen Wei, Yinling Zhu, Kun Li, Yanjiao Zhu, Yichuan Zhao, Zhiqiang Chang, Yan Xu
FEBS Letters.2018; 592(6): 973. CrossRef
SIRT7 suppresses the epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis by promoting SMAD4 deacetylation
Wenlu Li, Dandan Zhu, Shuaihua Qin
Journal of Experimental & Clinical Cancer Research.2018;[Epub] CrossRef
Sirtuin 7: a new marker of aggressiveness in prostate cancer
Romain Haider, Fabienne Massa, Lisa Kaminski, Stephan Clavel, Zied Djabari, Guillaume Robert, Kathiane Laurent, Jean-François Michiels, Matthieu Durand, Jean-Ehrland Ricci, Jean-François Tanti, Frédéric Bost, Damien Ambrosetti
Oncotarget.2017; 8(44): 77309. CrossRef

Tumor Sprouting in Papillary Thyroid Carcinoma Is Correlated with Lymph Node Metastasis and Recurrence: Eunjung Lee, Wonkyung Jung, Jeong-Soo Woo, Jae Bok Lee, Bong Kyung Shin, Han Kyeom Kim, Aeree Kim, Baek-hui Kim; Korean J Pathol. 2014;48(2):117-125. Published online April 28, 2014; DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.2.117

11,551 View
67 Download
7 Crossref

Abstract PDF

Background

Identification of poor prognostic factors in papillary thyroid carcinoma (PTC) patients is important for the patients' care and follow-up. We can sometimes see small tumor clusters without desmoplasia and no evidence of lymphatic emboli around the main tumor mass of PTC. We termed this form of tumor clustering, 'tumor sprouting,' and determined whether these tumors correlate with lymphovascular invasion, lymph node metastasis, and recurrence.

Methods

We analyzed a total of 204 cases of papillary thyroid macrocarcinoma. Number, size and distance from the main tumor of the tumor sprouting were observed and analyzed with clinicopathologic characteristics.

Results

Tumor sprouting was observed in 101 patients. Presence of tumor sprouting was significantly associated with positive resection margin (p=.002), lymphovascular invasion (p=.001), lymph node metastasis (p<.001), and recurrence (p=.004). Univariate analysis of recurrence-free survival revealed that tumor multiplicity (p=.037), positive resection margin (p=.007), lymphovascular invasion (p=.004), lymph node metastasis (p<.001), and tumor sprouting (p=.004) were poor prognostic factors. In multivariate analysis, positive resection margin was an independent poor prognostic factor of recurrence.

Conclusions

In conclusion, tumor sprouting is significantly correlated with lymph node metastasis and recurrence. Evaluation of tumor sprouting in PTC patients could be helpful in predicting tumor recurrence or lymph node metastasis.

Citations

Citations to this article as recorded by

Korean Thyroid Association Guidelines on the Management of Differentiated Thyroid Cancers; Part I. Initial Management of Differentiated Thyroid Cancers - Chapter 5. Evaluation of Recurrence Risk Postoperatively and Initial Risk Stratification in Different
Eun Kyung Lee, Young Shin Song, Ho-Cheol Kang, Sun Wook Kim, Dong Gyu Na, Shin Je Moon, Dong-Jun Lim, Kyong Yeun Jung, Yun Jae Chung, Chan Kwon Jung, Young Joo Park
International Journal of Thyroidology.2024; 17(1): 68. CrossRef
Significance of Lymphovascular Invasion as a Prognostic Factor in Patients with Papillary Thyroid Cancer: a Systematic Review and Meta-Analysis
Ho-Ryun Won, Bon Seok Koo
International Journal of Thyroidology.2023; 16(2): 157. CrossRef
Peripheral Versus Intraparenchymal Papillary Thyroid Microcarcinoma: Different Morphologies and PD-L1 Expression
Bozidar Kovacevic, Dragana Vucevic, Snezana Cerovic, Catarina Eloy
Head and Neck Pathology.2022; 16(1): 200. CrossRef
Lymphovascular invasion and risk of recurrence in papillary thyroid carcinoma
Katy Wagner, Earl Abraham, Bryan Tran, David Roshan, James Wykes, Peter Campbell, Ardalan Ebrahimi
ANZ Journal of Surgery.2020; 90(9): 1727. CrossRef
The Predictors of Multicentricity in Well-Differentiated Thyroid Cancer
Mohamed Hegazi, Waleed El Nahas, Mohamed Elmetwally, Amr Hassan, Waleed Gado , Islam Abdou, Ahmed Senbel, Mohamed Samir Abou-Sheishaa
Journal of Analytical Oncology.2018; 7(4): 65. CrossRef
Prognostic impact of vascular invasion in differentiated thyroid carcinoma: a systematic review and meta-analysis
Huy Gia Vuong, Tetsuo Kondo, Uyen N P Duong, Thong Quang Pham, Naoki Oishi, Kunio Mochizuki, Tadao Nakazawa, Lewis Hassell, Ryohei Katoh
European Journal of Endocrinology.2017; 177(2): 207. CrossRef
Detection of Tumor Multifocality Is Important for Prediction of Tumor Recurrence in Papillary Thyroid Microcarcinoma: A Retrospective Study and Meta-Analysis
Jung-Soo Pyo, Jin Hee Sohn, Guhyun Kang
Journal of Pathology and Translational Medicine.2016; 50(4): 278. CrossRef

SIRT1 Expression Is Associated with Good Prognosis in Colorectal Cancer: Wonkyung Jung, Kwang Dae Hong, Woon Yong Jung, Eunjung Lee, Bong Kyung Shin, Han Kyeom Kim, Aeree Kim, Baek-hui Kim; Korean J Pathol. 2013;47(4):332-339. Published online August 26, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.4.332

10,980 View
81 Download
42 Crossref

Abstract PDF

Background

Silent mating type information regulation 2 homolog 1 (SIRT1), an NAD+-dependent deacetylase, might act as a tumor promoter by inhibiting p53, but may also as a tumor suppressor by inhibiting several oncogenes such as β-catenin and survivin. Deleted in breast cancer 1 (DBC1) is known as a negative regulator of SIRT1.

Methods

Immunohistochemical expressions of SIRT1, DBC1, β-catenin, surviving, and p53 were evaluated using 2 mm tumor cores from 349 colorectal cancer patients for tissue microarray.

Results

Overexpression of SIRT1, DBC1, survivin, and p53 was seen in 235 (67%), 183 (52%), 193 (55%), and 190 (54%) patients, respectively. Altered expression of β-catenin was identified in 246 (70%) patients. On univariate analysis, overexpression of SIRT1 (p=0.029) and altered expression of β-catenin (p=0.008) were significantly associated with longer overall survival. Expression of SIRT1 was significantly related to DBC1 (p=0.001), β-catenin (p=0.001), and survivin (p=0.002), but not with p53. On multivariate analysis, age, tumor stage, differentiation, and expression of SIRT1 were independent prognostic factors significantly associated with overall survival.

Conclusions

SIRT1 overexpression is a good prognostic factor for colorectal cancer, and SIRT1 may interact with β-catenin and survivin rather than p53.

Citations

Citations to this article as recorded by

Ocular surface squamous neoplasia: Update on genetics, epigenetics and opportunities for targeted therapy
Nefeli Eleni Kounatidou, Evangelos Vitkos, Sotiria Palioura
The Ocular Surface.2025; 35: 1. CrossRef
The Prognostic Impact of SIRT1, STAT3, and YAP1 in Colorectal Carcinoma
Shimaa Elkholy, Aya Abdelbary, Dina Elazab, Mohamed Elkablawy, Asmaa G. Abdou
Applied Immunohistochemistry & Molecular Morphology.2025; 33(1): 29. CrossRef
The NR3C2-SIRT1 signaling axis promotes autophagy and inhibits epithelial mesenchymal transition in colorectal cancer
Feng Li, Xing Wan, Zhigui Li, Liming Zhou
Cell Death & Disease.2025;[Epub] CrossRef
ZMIZ1 Regulates Proliferation, Autophagy and Apoptosis of Colon Cancer Cells by Mediating Ubiquitin–Proteasome Degradation of SIRT1
Min Huang, Junfeng Wang, Zhengrong Zhang, Xueliang Zuo
Biochemical Genetics.2024; 62(4): 3245. CrossRef
Research Progress of Biological Function and Prognosis of Colorectal Cancer in Sirtuins Family
瑞阳李
Journal of Clinical Personalized Medicine.2024; 03(04): 1805. CrossRef
Oncogenic KRAS mutation confers chemoresistance by upregulating SIRT1 in non-small cell lung cancer
Dong Hoon Shin, Jeong Yeon Jo, Minyoung Choi, Kyung-Hee Kim, Young-Ki Bae, Sang Soo Kim
Experimental & Molecular Medicine.2023; 55(10): 2220. CrossRef
Association of β-Catenin, APC, SMAD3/4, Tp53, and Cyclin D1 Genes in Colorectal Cancer: A Systematic Review and Meta-Analysis
Hongfeng Yan, Fuquan Jiang, Jianwu Yang, Ying-Kun Xu
Genetics Research.2022; 2022: 1. CrossRef
Resveratrol-related compounds: Potential for cancer and beyond
MONICA SAVIO, VALENTINA MINOIA, PAOLA FULGHIERI, LUCIA ANNA STIVALA, VIRGINIE SOTTILE
BIOCELL.2022; 46(12): 2525. CrossRef
The relationship between β-catenin and patient survival in colorectal cancer systematic review and meta-analysis
Amna Matly, Jean A. Quinn, Donald C. McMillan, James H. Park, Joanne Edwards
Critical Reviews in Oncology/Hematology.2021; 163: 103337. CrossRef
Trending topics of SIRT1 in tumorigenicity
Liz M. Garcia-Peterson, Xiaoling Li
Biochimica et Biophysica Acta (BBA) - General Subjects.2021; 1865(9): 129952. CrossRef
Surtuin 1 as a potential prognostic biomarker in very elderly patients with colorectal cancer
Guk Jin Lee, Yun Hwa Jung, Tae-Jung Kim, Yosep Chong, Seo-Won Jeong, In Kyu Lee, In Sook Woo
The Korean Journal of Internal Medicine.2021; 36(Suppl 1): S235. CrossRef
Survival and Clinicopathological Significance of SIRT1 Expression in Cancers: A Meta-Analysis
Min Sun, Mengyu Du, Wenhua Zhang, Sisi Xiong, Xingrui Gong, Peijie Lei, Jin Zha, Hongrui Zhu, Heng Li, Dong Huang, Xinsheng Gu
Frontiers in Endocrinology.2019;[Epub] CrossRef
SIRT1: a potential tumour biomarker and therapeutic target
Bin Zhao, Xin Li, Liangfu Zhou, Ye Wang, Peng Shang
Journal of Drug Targeting.2019; 27(10): 1046. CrossRef
The clinicopathological significance of SIRT1 expression in colon cancer: An immunohistochemical study and meta-analysis
Won Gi Hong, Jung-Soo Pyo
Pathology - Research and Practice.2018; 214(10): 1550. CrossRef
Sirtuin 1 and oral cancer (Review)
Shajedul Islam, Yoshihiro Abiko, Osamu Uehara, Itsuo Chiba
Oncology Letters.2018;[Epub] CrossRef
A novel SIRT1 inhibitor, 4bb induces apoptosis in HCT116 human colon carcinoma cells partially by activating p53
Ananga Ghosh, Amrita Sengupta, Guru Pavan Kumar Seerapu, Ali Nakhi, E.V. Venkat Shivaji Ramarao, Navneet Bung, Gopalakrishnan Bulusu, Manojit Pal, Devyani Haldar
Biochemical and Biophysical Research Communications.2017; 488(3): 562. CrossRef
SIRT1 gene polymorphisms and its protein level in colorectal cancer
Olfat Gamil Shaker, Miriam Safwat Wadie, Reham Maher Mohamed Ali, Ayman Yosry
Gene Reports.2017; 7: 164. CrossRef
Overexpression of SIRT1 is Associated With Poor Outcomes in Patients With Ovarian Carcinoma
David H. Mvunta, Tsutomu Miyamoto, Ryoichi Asaka, Yasushi Yamada, Hirofumi Ando, Shotaro Higuchi, Koichi Ida, Hiroyasu Kashima, Tanri Shiozawa
Applied Immunohistochemistry & Molecular Morphology.2017; 25(6): 415. CrossRef
SIRT1 suppresses colorectal cancer metastasis by transcriptional repression of miR-15b-5p
Li-Na Sun, Zheng Zhi, Liang-Yan Chen, Qun Zhou, Xiu-Ming Li, Wen-Juan Gan, Shu Chen, Meng Yang, Yao Liu, Tong Shen, Yong Xu, Jian-Ming Li
Cancer Letters.2017; 409: 104. CrossRef
TrpC5 regulates differentiation through the Ca2+/Wnt5a signalling pathway in colorectal cancer
Zhen Chen, Chunlei Tang, Yaodan Zhu, Mingxu Xie, Dongxu He, Qiongxi Pan, Peng Zhang, Dong Hua, Teng Wang, Linfang Jin, Xiaowei Qi, Yifei Zhu, Xiaoqiang Yao, Jian Jin, Xin Ma
Clinical Science.2017; 131(3): 227. CrossRef
Meta-analysis of SIRT1 expression as a prognostic marker for overall survival in gastrointestinal cancer
Shuangjie Wu, Jinghui Jiang, Jun Liu, Xinhai Wang, Yu Gan, Yifan Tang
Oncotarget.2017; 8(37): 62589. CrossRef
Prognostic and clinicopathological significance of SIRT1 expression in NSCLC: a meta-analysis
Yifei Chen, Tao Wang, Wei Wang, Jiahao Hu, Ruiting Li, Shaojun He, Jiong Yang
Oncotarget.2017; 8(37): 62537. CrossRef
The prognostic role of Sirt1 expression in solid malignancies: a meta-analysis
Changwen Wang, Wen Yang, Fang Dong, Yawen Guo, Jie Tan, Shengnan Ruan, Tao Huang
Oncotarget.2017; 8(39): 66343. CrossRef
SIRT1 induces tumor invasion by targeting epithelial mesenchymal transition-related pathway and is a prognostic marker in triple negative breast cancer
Min-Sun Jin, Chang Lim Hyun, In Ae Park, Ji Young Kim, Yul Ri Chung, Seock-Ah Im, Kyung-Hun Lee, Hyeong-Gon Moon, Han Suk Ryu
Tumor Biology.2016; 37(4): 4743. CrossRef
Survivin and SIRT1: can be two prognostic factors in chronic myeloid leukemia?
Fatemeh Salari, Javad Mohammdai-asl, Amal Saki Malehi, Ahmad Ahmadzadeh, Mohammad Ali Jalali far, Zari Tahannejad Asadi, Najmaldin Saki
Comparative Clinical Pathology.2016; 25(2): 415. CrossRef
Clinicopathological significance of SIRT1 expression in colorectal cancer: A systematic review and meta analysis
Guo Zu, Anlong Ji, Tingting Zhou, Ningwei Che
International Journal of Surgery.2016; 26: 32. CrossRef
The small molecule survivin inhibitor YM155 may be an effective treatment modality for colon cancer through increasing apoptosis
Wan Lu Li, Mi-Ra Lee, Mee-Yon Cho
Biochemical and Biophysical Research Communications.2016; 471(2): 309. CrossRef
Nuclear expression and/or reduced membranous expression of β-catenin correlate with poor prognosis in colorectal carcinoma
Shizhen Zhang, Zhen Wang, Jinlan Shan, Xiuyan Yu, Ling Li, Rui Lei, Daozhe Lin, Siqi Guan, Xiaochen Wang
Medicine.2016; 95(49): e5546. CrossRef
Association of SIRT1 and HMGA1 expression in non-small cell lung cancer
SHUANG-YAN LIN, FANG PENG
Oncology Letters.2016; 11(1): 782. CrossRef
SIRT1 is a regulator of autophagy: Implications in gastric cancer progression and treatment
Guanglin Qiu, Xuqi Li, Xiangming Che, Chao Wei, Shicai He, Jing Lu, Zongliang Jia, Ke Pang, Lin Fan
FEBS Letters.2015; 589(16): 2034. CrossRef
Stromal expression of miR-21 in T3-4a colorectal cancer is an independent predictor of early tumor relapse
Won Kyung Kang, Jin Kwon Lee, Seong Taek Oh, Sung Hak Lee, Chan Kwon Jung
BMC Gastroenterology.2015;[Epub] CrossRef
Association of SIRT1 and tumor suppressor gene TAp63 expression in head and neck squamous cell carcinoma
Keiji Kikuchi, Akira Noguchi, Rika Kasajima, Yohei Miyagi, Daisuke Hoshino, Naohiko Koshikawa, Akira Kubota, Tomoyuki Yokose, Yasuo Takano
Tumor Biology.2015; 36(10): 7865. CrossRef
Differential expressions of cancer-associated genes and their regulatory miRNAs in colorectal carcinoma
Murat Kara, Onder Yumrutas, Onder Ozcan, Ozgur Ilhan Celik, Esra Bozgeyik, Ibrahim Bozgeyik, Sener Tasdemir
Gene.2015; 567(1): 81. CrossRef
Distinctive role of SIRT1 expression on tumor invasion and metastasis in breast cancer by molecular subtype
Yul Ri Chung, Hyojin Kim, Soo Young Park, In Ae Park, Ja June Jang, Ji-Young Choe, Yoon Yang Jung, Seock-Ah Im, Hyeong-Gon Moon, Kyung-Hun Lee, Koung Jin Suh, Tae-Yong Kim, Dong-Young Noh, Wonshik Han, Han Suk Ryu
Human Pathology.2015; 46(7): 1027. CrossRef
Expression of ROR1, pAkt, and pCREB in gastric adenocarcinoma
Hyeyoon Chang, Woon Yong Jung, Youngran Kang, Hyunjoo Lee, Aeree Kim, Baek-hui Kim
Annals of Diagnostic Pathology.2015; 19(5): 330. CrossRef
miR-34a inhibits cell proliferation in prostate cancer by downregulation of SIRT1 expression
KUN DUAN, YONG-CHAO GE, XUE-PEI ZHANG, SHU-YI WU, JIN-SHUN FENG, SHI-LIN CHEN, LI ZHANG, ZHI-HAO YUAN, CHAO-HONG FU
Oncology Letters.2015; 10(5): 3223. CrossRef
Immunohistochemical Characterization of Large Intestinal Adenocarcinoma in the Rhesus Macaque (Macaca mulatta)
C. E. Harbison, F. Taheri, H. Knight, A. D. Miller
Veterinary Pathology.2015; 52(4): 732. CrossRef
Correlation and prognostic value of SIRT1 and Notch1 signaling in breast cancer
Yu-Wen Cao, Wen-Qin Li, Guo-Xing Wan, Yi-Xiao Li, Xiao-Ming Du, Yu-Cong Li, Feng Li
Journal of Experimental & Clinical Cancer Research.2014;[Epub] CrossRef
Fentanyl Increases Colorectal Carcinoma Cell Apoptosis by Inhibition of NF-κB in a Sirt1-dependent Manner
Xiu-Lai Zhang, Min-Li Chen, Sheng-Li Zhou
Asian Pacific Journal of Cancer Prevention.2014; 15(22): 10015. CrossRef
Elevated HOXB9 expression promotes differentiation and predicts a favourable outcome in colon adenocarcinoma patients
J Zhan, M Niu, P Wang, X Zhu, S Li, J Song, H He, Y Wang, L Xue, W Fang, H Zhang
British Journal of Cancer.2014; 111(5): 883. CrossRef
Prognostic Factors for Metastatic Colorectal Cancer after First-line Chemotherapy with FOLFOX-4 or FOLFIRI Regimen
Jae Hyun Kim, Pyoung Rak Choi, Seun Ja Park, Moo In Park, Won Moon, Sung Eun Kim, Gyu Won Lee
The Korean Journal of Gastroenterology.2014; 63(4): 209. CrossRef
Down-Regulation of mir-221 and mir-222 Restrain Prostate Cancer Cell Proliferation and Migration That Is Partly Mediated by Activation of SIRT1
Xiao Yang, Yingmei Yang, Rong Gan, Lingxu Zhao, Wei Li, Huaibin Zhou, Xiaojuan Wang, Jianxin Lu, Qing H. Meng, George Calin
PLoS ONE.2014; 9(6): e98833. CrossRef

Prognostic Significance of Heat Shock Protein 70 Expression in Early Gastric Carcinoma: Youngran Kang, Woon Yong Jung, Hyunjoo Lee, Wonkyung Jung, Eunjung Lee, Bong Kyung Shin, Aeree Kim, Han Kyeom Kim, Baek-hui Kim; Korean J Pathol. 2013;47(3):219-226. Published online June 25, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.3.219

8,523 View
36 Download
8 Crossref

Abstract PDF

Background

Overexpression of heat shock protein 70 (HSP70) has been observed in many types of cancer including gastric adenocarcinomas, although the exact role of HSP70 in carcinogenesis remains unclear.

Methods

The study analyzed a total of 458 radical gastrectomy specimens which were immunohistochemically stained with HSP70, p53, and Ki-67 antibodies.

Results

The study determined that the expression of HSP70 was significantly increased in early gastric cancer (EGC) compared to advanced gastric cancer (p<0.001). The HSP70 expression was correlated with well-differentiated tumor type, intestinal type of Lauren classification and the lower pT and pN stage. Negative expression of Ki-67 and p53 expression was associated with poor prognosis. The study did not find any correlation between HSP70 and p53 expression. The study determined that HSP70 expression in the EGC subgroup was associated with a poor prognosis (p=0.009), as well as negative Ki-67 expression (p=0.006), but was not associated with p53. Based on multivariate analysis, HSP70 expression (p=0.024), negative expression of Ki-67, invasion depth and lymph node metastasis were determined to be independent prognostic markers.

Conclusions

HSP70 is expressed in the early stages of gastric adenocarcinoma. In EGC, HSP70 is a poor independent prognostic marker and is correlated with a low proliferation index.

Citations

Citations to this article as recorded by

The Prognostic Importance of Ki-67 in Gastrointestinal Carcinomas: A Meta-analysis and Multi-omics Approach
Mahdieh Razmi, Fatemeh Tajik, Farideh Hashemi, Ayna Yazdanpanah, Fatemeh Hashemi-Niasari, Adeleh Divsalar
Journal of Gastrointestinal Cancer.2024; 55(2): 599. CrossRef
Clinicopathological significance of HSP70 expression in gastric cancer: a systematic review and meta-analysis
Xiaolu Wang, Li Xie, Lijing Zhu
BMC Gastroenterology.2021;[Epub] CrossRef
Beta-sheet-specific interactions with heat shock proteins define a mechanism of delayed tumor cell death in response to HAMLET
Aftab Nadeem, James C.S. Ho, Tuan Hiep Tran, Sanchari Paul, Victoria Granqvist, Nadege Despretz, Catharina Svanborg
Journal of Molecular Biology.2019; 431(14): 2612. CrossRef
Evolving paradigms on the interplay of mitochondrial Hsp70 chaperone system in cell survival and senescence
Shubhi Srivastava, Vinaya Vishwanathan, Abhijit Birje, Devanjan Sinha, Patrick D’Silva
Critical Reviews in Biochemistry and Molecular Biology.2019; 54(6): 517. CrossRef
Clinicopathologic significance and prognostic value of Ki-67 expression in patients with gastric cancer: a meta-analysis
Guanying Luo, Yunzhao Hu, Zhiqiao Zhang, Peng Wang, Zhaowen Luo, Jinxin Lin, Canchang Cheng, You Yang
Oncotarget.2017; 8(30): 50273. CrossRef
Extracellular HSP70-peptide complexes promote the proliferation of hepatocellular carcinoma cells via TLR2/4/JNK1/2MAPK pathway
Yi Zhe, Yan Li, Dan Liu, Dong-Ming Su, Jin-Gang Liu, Hang-Yu Li
Tumor Biology.2016; 37(10): 13951. CrossRef
The cytomegalovirus protein UL138 induces apoptosis of gastric cancer cells by binding to heat shock protein 70
Wenjing Chen, Kezhi Lin, Liang Zhang, Gangqiang Guo, Xiangwei Sun, Jing Chen, Lulu Ye, Sisi Ye, Chenchen Mao, Jianfeng Xu, Lifang Zhang, Lubin Jiang, Xian Shen, Xiangyang Xue
Oncotarget.2016; 7(5): 5630. CrossRef
Targeting the hsp70 gene delays mammary tumor initiation and inhibits tumor cell metastasis
J Gong, D Weng, T Eguchi, A Murshid, M Y Sherman, B Song, S K Calderwood
Oncogene.2015; 34(43): 5460. CrossRef

Expression of SIRT1 and DBC1 in Gastric Adenocarcinoma: Youngran Kang, Woon Yong Jung, Hyunjoo Lee, Eunjung Lee, Aeree Kim, Baek-hui Kim; Korean J Pathol. 2012;46(6):523-531. Published online December 26, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.6.523

9,077 View
50 Download
30 Crossref

Abstract PDF

Background

Sirtuin 1 (SIRT1) and deleted in breast cancer 1 (DBC1) are known as tumor suppressor or promoter genes. This may be due to their diverse functions and interaction with other proteins. Gastric adenocarcinoma is one of the most common malignancies, but little is known about its carcinogenesis. Therefore, we investigated the association of immunohistochemical expression of SIRT1, DBC1, p53, and β-catenin and their variable clinicopathological characteristics.

Methods

We obtained samples from 452 patients who underwent gastrectomy. Tissue microarray blocks were constructed and immonohistochemical staining was performed.

Results

Expression of DBC1 and SIRT1 was associated with lower histologic grade, intestinal type of Lauren classification, and lower pT (p<0.001) and pN stage (DBC1, p=0.002; SIRT1, p<0.001). Association between absence of lymphatic invasion, and SIRT1 (p=0.001) and DBC1 (p=0.004) was observed. Cytoplasmic β-catenin expression was associated with lower histologic grade, pT, pN, tumor-node-metastasis (TNM) stage, DBC1 (p<0.001), and SIRT1 (p=0.001). Expression of SIRT1 and DBC1 was not associated with p53 (p=0.063 and p=0.060). DBC1 was an independent good prognostic factor in multivariate analysis (p=0.012).

Conclusions

SIRC1 and DBC1 can be considered to be good prognostic factors in gastric adenocarcinoma.

Citations

Citations to this article as recorded by

Regulatory role of DBC1 in inflammation and autoimmune diseases
Jinzhi Wu, Fan Yang, Guanhua Xu, Xinlei Ma, Jin Lin, Weiqian Chen
Rheumatology & Autoimmunity.2025; 5(1): 15. CrossRef
Mechanistic insights into the dual role of CCAR2/DBC1 in cancer
Hwa Jin Kim, Sue Jin Moon, Jeong Hoon Kim
Experimental & Molecular Medicine.2023; 55(8): 1691. CrossRef
Sirtuins (SIRTs) As a Novel Target in Gastric Cancer
Agata Poniewierska-Baran, Paulina Warias, Katarzyna Zgutka
International Journal of Molecular Sciences.2022; 23(23): 15119. CrossRef
Histone Deacetylase Functions in Gastric Cancer: Therapeutic Target?
Amandine Badie, Christian Gaiddon, Georg Mellitzer
Cancers.2022; 14(21): 5472. CrossRef
Advances on the role of the deleted in breast cancer (DBC1) in cancer and autoimmune diseases
Qiannan Fang, Joseph A Bellanti, Song Guo Zheng
Journal of Leukocyte Biology.2021; 109(2): 449. CrossRef
miR-1301-3p Promotes Cell Proliferation and Facilitates Cell Cycle Progression via Targeting SIRT1 in Gastric Cancer
Dakui Luo, Hao Fan, Xiang Ma, Chao Yang, Yu He, Yugang Ge, Mingkun Jiang, Zekuan Xu, Li Yang
Frontiers in Oncology.2021;[Epub] CrossRef
CCAR1 and CCAR2 as gene chameleons with antagonistic duality: Preclinical, human translational, and mechanistic basis
Gavin S. Johnson, Praveen Rajendran, Roderick H. Dashwood
Cancer Science.2020; 111(10): 3416. CrossRef
Role of Histone Acetylation in Gastric Cancer: Implications of Dietetic Compounds and Clinical Perspectives
Danielle Q Calcagno, Fernanda Wisnieski, Elizangela R da Silva Mota, Stefanie B Maia de Sousa, Jéssica M Costa da Silva, Mariana F Leal, Carolina O Gigek, Leonardo C Santos, Lucas T Rasmussen, Paulo P Assumpção, Rommel R Burbano, Marília AC Smith
Epigenomics.2019; 11(3): 349. CrossRef
Survival and Clinicopathological Significance of SIRT1 Expression in Cancers: A Meta-Analysis
Min Sun, Mengyu Du, Wenhua Zhang, Sisi Xiong, Xingrui Gong, Peijie Lei, Jin Zha, Hongrui Zhu, Heng Li, Dong Huang, Xinsheng Gu
Frontiers in Endocrinology.2019;[Epub] CrossRef
Cell cycle and apoptosis regulator 2 at the interface between DNA damage response and cell physiology
Martina Magni, Giacomo Buscemi, Laura Zannini
Mutation Research/Reviews in Mutation Research.2018; 776: 1. CrossRef
NANOGP8 expression regulates gastric cancer cell progression by transactivating DBC1 in gastric cancer MKN‑45 cells
Li Li, Ru Feng, Sujuan Fei, Jiang Cao, Qinqin Zhu, Guozhong Ji, Jianwei Zhou
Oncology Letters.2018;[Epub] CrossRef
Overexpression of DBC1, correlated with poor prognosis, is a potential therapeutic target for hepatocellular carcinoma
Changcan Li, Jianhua Liao, Shaohan Wu, Junwei Fan, Zhihai Peng, Zhaowen Wang
Biochemical and Biophysical Research Communications.2017; 494(3-4): 511. CrossRef
Association of sirtuins with clinicopathological parameters and overall survival in gastric cancer
Xiaobing Shen, Pengfei Li, Yuchao Xu, Xiaowei Chen, Haixiang Sun, Ying Zhao, Mengqi Liu, Wenwen Zhang
Oncotarget.2017; 8(43): 74359. CrossRef
Co-ordinated overexpression of SIRT1 and STAT3 is associated with poor survival outcome in gastric cancer patients
Shu Zhang, Shuling Huang, Chao Deng, Yu Cao, Jun Yang, Guangxia Chen, Bin Zhang, Chaoqin Duan, Jiong Shi, Bo Kong, Helmut Friess, Nanyi Zhao, Chen Huang, Xiaoli Huang, Lei Wang, Xiaoping Zou
Oncotarget.2017; 8(12): 18848. CrossRef
The prognostic role of Sirt1 expression in solid malignancies: a meta-analysis
Changwen Wang, Wen Yang, Fang Dong, Yawen Guo, Jie Tan, Shengnan Ruan, Tao Huang
Oncotarget.2017; 8(39): 66343. CrossRef
SIRT1 induces tumor invasion by targeting epithelial mesenchymal transition-related pathway and is a prognostic marker in triple negative breast cancer
Min-Sun Jin, Chang Lim Hyun, In Ae Park, Ji Young Kim, Yul Ri Chung, Seock-Ah Im, Kyung-Hun Lee, Hyeong-Gon Moon, Han Suk Ryu
Tumor Biology.2016; 37(4): 4743. CrossRef
Prognostic and clinical value of Sirt1 expression in gastric cancer: A systematic meta-analysis
Bin Jiang, Jin-huang Chen, Wen-zheng Yuan, Jin-tong Ji, Zheng-yi Liu, Liang Wu, Qiang Tang, Xiao-gang Shu
Journal of Huazhong University of Science and Technology [Medical Sciences].2016; 36(2): 278. CrossRef
Significance of silent mating type information regulation 2 homolog 1 and claudin 4 expression in gastric carcinoma and precursor lesions
Nashwa M. Emara, Ranih Z. Amer, Khaled M. Elsadek Attia, Heba M. Rashad, Adel Z. Elseady, Abd El-Latif M. Elbalshy
Egyptian Journal of Pathology.2016; 36(2): 158. CrossRef
Distinctive role of SIRT1 expression on tumor invasion and metastasis in breast cancer by molecular subtype
Yul Ri Chung, Hyojin Kim, Soo Young Park, In Ae Park, Ja June Jang, Ji-Young Choe, Yoon Yang Jung, Seock-Ah Im, Hyeong-Gon Moon, Kyung-Hun Lee, Koung Jin Suh, Tae-Yong Kim, Dong-Young Noh, Wonshik Han, Han Suk Ryu
Human Pathology.2015; 46(7): 1027. CrossRef
SIRT1 is a regulator of autophagy: Implications in gastric cancer progression and treatment
Guanglin Qiu, Xuqi Li, Xiangming Che, Chao Wei, Shicai He, Jing Lu, Zongliang Jia, Ke Pang, Lin Fan
FEBS Letters.2015; 589(16): 2034. CrossRef
DBC1 Functions as a Tumor Suppressor by Regulating p53 Stability
Bo Qin, Katherine Minter-Dykhouse, Jia Yu, Jun Zhang, Tongzheng Liu, Haoxing Zhang, SeungBaek Lee, JungJin Kim, Liewei Wang, Zhenkun Lou
Cell Reports.2015; 10(8): 1324. CrossRef
DBC1 promotes anoikis resistance of gastric cancer cells by regulating NF-κB activity
YONGWEI HUAN, DEPING WU, DAYONG ZHOU, BO SUN, GUOXIN LI
Oncology Reports.2015; 34(2): 843. CrossRef
Resveratrol relieves ischemia‑induced oxidative stress in the hippocampus by activating SIRT1
Zhuangzhi Meng, Jianguo Li, Honglin Zhao, Haiying Liu, Guowei Zhang, Lingzhan Wang, He Hu, Di Li, Mingjing Liu, Fulong Bi, Xiaoping Wang, Geng Tian, Qiang Liu, Batu Buren
Experimental and Therapeutic Medicine.2015;[Epub] CrossRef
CCAR2 deficiency augments genotoxic stress-induced apoptosis in the presence of melatonin in non-small cell lung cancer cells
Wootae Kim, Joo-Won Jeong, Ja-Eun Kim
Tumor Biology.2014; 35(11): 10919. CrossRef
Radioprotective and Antioxidant Effect of Resveratrol in Hippocampus by Activating Sirt1
Jianguo Li, Li Feng, Yonghua Xing, Yan Wang, Liqing Du, Chang Xu, Jia Cao, Qin Wang, Saijun Fan, Qiang Liu, Feiyue Fan
International Journal of Molecular Sciences.2014; 15(4): 5928. CrossRef
SIRT1 expression is associated with a poor prognosis, whereas DBC1 is associated with favorable outcomes in gastric cancer
Akira Noguchi, Keiji Kikuchi, Huachuan Zheng, Hiroyuki Takahashi, Yohei Miyagi, Ichiro Aoki, Yasuo Takano
Cancer Medicine.2014; 3(6): 1553. CrossRef
Sirtuins and Cancer: New Insights and Cell Signaling
Marcos Vinícius Macedo de Oliveira, João Marcus Oliveira Andrade, Alanna Fernandes Paraíso, Sérgio Henrique Sousa Santos
Cancer Investigation.2013; 31(10): 645. CrossRef
Deleted in breast cancer-1 (DBC-1) in the interface between metabolism, aging and cancer
Eduardo Nunes Chini, Claudia C. S. Chini, Veronica Nin, Carlos Escande
Bioscience Reports.2013;[Epub] CrossRef
SIRT1 Expression Is Associated with Good Prognosis in Colorectal Cancer
Wonkyung Jung, Kwang Dae Hong, Woon Yong Jung, Eunjung Lee, Bong Kyung Shin, Han Kyeom Kim, Aeree Kim, Baek-hui Kim
Korean Journal of Pathology.2013; 47(4): 332. CrossRef
Clinicopathological significance of SIRT1 and p300/CBP expression in gastroesophageal junction (GEJ) cancer and the correlation with E-cadherin and MLH1
Li-Hua Zhang, Qin Huang, Xiang-Shan Fan, Hong-Yan Wu, Jun Yang, An-Ning Feng
Pathology - Research and Practice.2013; 209(10): 611. CrossRef

Author index