Journal of Pathology and Translational Medicine

Case Study

Recurrent malignant solitary fibrous tumor of the scalp: a case report and literature review: Ahmed Rabie, Abdulkarim Hasan, Yasein Mohammed, Ayman Abdelmaksoud, Ali A. Rabaan; J Pathol Transl Med. 2022;56(2):103-108. Published online January 21, 2022; DOI: https://doi.org/10.4132/jptm.2021.10.29

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Solitary fibrous tumor (SFT) is a rare type of mesenchymal neoplasm that first was discovered in the pleura but can also affect the peritoneum, lungs, mediastinum, and skin. Cutaneous malignant SFT is an extremely rare tumor that resembles dermatofibrosacoma protuberance (DFSP) histologically and immunohistochemically. Herein, we describe a case of malignant SFT that presented as a recurrent mass on the scalp. The first lesion was totally excised one year before recurrence and was diagnosed as a DFSP based on the histopathology and cluster of differentiation 34 immunostaining positivity. Re-examination of the previously examined specimen was considered. Activator of transcription 6 positivity was also detected in the tissue, confirming the diagnosis of a recurrent malignant SFT rather than DFSP. There was no evidence of recurrence, locoregional, or distant metastases at six months after lesion removal with a safety margin.

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Prolonged generalized osteomalacia associated with a sinonasal cavity phosphaturic mesenchymal tumor: A case report
Mehdi Montazer, Naser Tayyebi Meibodi, Elmira Teymouri, Zohreh Mousavi, Sedigheh Reisian, Motahare Ebrahimnejad
Clinical Case Reports.2024;[Epub] CrossRef
Giant Cell Tumor of Soft Tissue on the Forearm Skin: Case Report and Literature Review
Abdulkarim Hasan, Khalid Nafie, Mohamed Adwi, Ayman Abdelmaksoud, Mohammed S. Abdelwahed, Abdulhadi Samman, Mohammad A. Alghamdi, Hasan S. Al-Ghamdi, Hind Ali Hendi, S. K. A. Horsu
Open Access Macedonian Journal of Medical Sciences.2023; 11(C): 71. CrossRef
Primary sclerosing liposarcoma of the ovary: Case report and a review of the literature
Thyagaraja Dhanurjaya, Turnbull Hilary, Jasenka Mazibrada
International Journal of Surgery Case Reports.2023; 109: 108513. CrossRef
Favorable outcome of a histiocytic sarcoma patient treated with immune checkpoint inhibitor: a case report
Long Thanh Nguyen, Giang Hoang Pham, Phuong Thi Vu, Hyeon Gyu Yi
Annals of Medicine & Surgery.2023; 85(12): 6274. CrossRef
Adrenal Solitary Fibrous Tumor: A Case Report
Elena Casademunt-Gras, Isabel Salinas, Pau Moreno Santabarbara, Gustavo Tapia Melendo, Jordi L Reverter
Cureus.2023;[Epub] CrossRef
A Rare Case of Malignant Solitary Fibrous Tumor on the Scalp
Kwang-Ryeol Kim, Ki Hong Kim
Keimyung Medical Journal.2023; 42(2): 107. CrossRef

Original Article

Clinicopathologic features of cutaneous metastases from internal malignancies: Hyeong Mok Kwon, Gyu Yeong Kim, Dong Hoon Shin, Young Kyung Bae; J Pathol Transl Med. 2021;55(4):289-297. Published online July 7, 2021; DOI: https://doi.org/10.4132/jptm.2021.05.24

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Abstract PDF Supplementary Material

Background
Cutaneous metastasis (CM) is the spread of cancer cells from a primary site to the skin and is rarely the first sign of silent cancer. We investigated the clinicopathological characteristics of CM from internal malignancies in Korean patients treated at our institution over 20 years.
Methods
The clinicopathological findings of 112 patients (62 females, 50 males) with CM diagnosed at Yeungnam University Hospital between 2000 and 2020 were retrospectively reviewed.
Results
Mean patient age was 58.6 years (range, 26 to 87 years), and the most common primary cancer site was breast (74.2%) in women and lung (36.0%) in men. Ninety-six patients (85.7%) presented with CM after primary tumor diagnosis. CM from the lung or biliary tract usually occurred within 2 years of primary tumor diagnosis, whereas metastases from the breast and kidney occurred several years later. The chest, abdomen, and scalp were common sites of CM. Breast cancer usually metastasized to chest skin, while gastrointestinal tract cancers commonly metastasized to the abdomen. The scalp was a common location for CM from various tumors. The most common dermatologic presentations were nodules and masses. Immunohistochemical studies helped identify underlying malignancies when primary tumors were unknown.
Conclusions
The relative frequency of CM parallels the overall incidence of primary malignant tumors, and CMs usually occur at anatomic sites close to the primary tumor. CM can be diagnosed based on clinical, radiological, and histological features; however, immunohistochemical study is required in some cases.

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A Mirror of Metastatic Destiny – A Case Series of Cutaneous Metastases
Rochelle Monteiro, Monisha Madhumita, Hemanth Kumar, Jacintha Martis
Clinical Dermatology Review.2024; 8(1): 58. CrossRef
Nonbrain metastases seen on magnetic resonance imaging during metastatic brain tumor screening
Mio Sakai, Nobuo Kashiwagi, Katsuyuki Nakanishi, Noboru Maeda, Yasuhiro Nakaya, Junichiro Tanaka, Shinichiro Watanabe, Hidenari Hongyo, Yu Tanaka, Sawaka Yamada, Atsushi Kawata, Sou Toda, Koji Takano, Hideyuki Arita, Noriyuki Tomiyama
Japanese Journal of Radiology.2023; 41(4): 367. CrossRef
Cutaneous Metastasis as a Diagnostic Prelude in a 48-year-old Female
Nagatoshi M. Ebisawa, Isabel G. Palabyab-Imperial, Leilani R. Senador, Luella Joy A. Escueta-Alcos
Journal of the Philippine Dermatological Society.2023; 32(2): 107. CrossRef
Pigmented epidermotropic breast cancer metastases: A rare variant with a particularly unusual feature
Juan Torre‐Castro, Cristina Moya‐Martínez, Lara Haya‐Martínez, María Dolores Mendoza‐Cembranos, Itziar Eraña‐Tomás, Luis Requena
Journal of Cutaneous Pathology.2022; 49(1): 99. CrossRef
Skin metastases in the clinical and dermoscopic aspects
Grazyna Kamińska-Winciorek, Aleksandra Pilśniak, Wojciech Piskorski, Jerzy Wydmański
Seminars in Oncology.2022; 49(2): 160. CrossRef
Dermoscopy and novel non invasive imaging of Cutaneous Metastases
Dimitrios Alexandris, Nektarios Alevizopoulos, Leonidas Marinos, Charikleia Gakiopoulou
Advances in Cancer Biology - Metastasis.2022; 6: 100078. CrossRef

Case Studies

A case of cribriform carcinoma of the skin: a newly described rare condition: Hyun Lee, Chong-Hyun Won, Chan-Sik Park; J Pathol Transl Med. 2021;55(1):68-74. Published online December 3, 2020; DOI: https://doi.org/10.4132/jptm.2020.10.05

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Abstract PDF

Primary cribriform carcinoma of the skin is an indolent, rare, adnexal tumor. Although its malignant potential remains uncertain, no recurrence or metastasis has been reported. A 33-year-old man presented with a solitary, erythematous, subcutaneous nodule on the right knee. The clinical impression was epidermal cyst, and the resected tumor demonstrated a well-circumscribed mass in the dermis and subcutis. The tumor was composed of two regions: a solid component and a cribriform component. The solid component (90%) showed multiple solid nests of epithelial cells. Individual cells had large, oval-to-round, hyperchromatic, pleomorphic nuclei with a nuclear groove. The cribriform component (10%) showed similar neoplastic cells with many prominent lumina. Some lumina had an eosinophilic substance that exhibited a positive periodic acid-Schiff reaction. No recurrence or metastasis was observed within a followup period of eight months after excision. In conclusion, we report the first case of primary cribriform carcinoma of the skin in Korea.

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Mohs micrographic surgery for the management of primary cutaneous cribriform carcinoma of the back
Min Jae Kim, Je‐Ho Mun
JDDG: Journal der Deutschen Dermatologischen Gesellschaft.2024; 22(4): 584. CrossRef
Mikrographische Chirurgie nach Mohs bei einem primär kutanen kribriformen Karzinom am Rücken
Min Jae Kim, Je‐Ho Mun
JDDG: Journal der Deutschen Dermatologischen Gesellschaft.2024; 22(4): 584. CrossRef
Primary cutaneous cribriform tumor: A case report and literature review
Doukou Jiang, Yongzhen Tian, Jiabin Tian, Hui Liu, Yang Guan
Journal of Cutaneous Pathology.2024;[Epub] CrossRef
Rare skin appendage tumour on the right leg: a case of primary cutaneous cribriform carcinoma
Kashini Andrew, James M Carr, Claudia Roberts
BMJ Case Reports.2023; 16(5): e254781. CrossRef

Squamous Cell Carcinoma of the Extrahepatic Common Hepatic Duct: Myunghee Kang, Na Rae Kim, Dong Hae Chung, Hyun Yee Cho, Yeon Ho Park; J Pathol Transl Med. 2019;53(2):112-118. Published online October 1, 2018; DOI: https://doi.org/10.4132/jptm.2018.09.03

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Abstract PDF

We report a rare case of hilar squamous cell carcinoma. A 62-year-old Korean woman complaining of nausea was referred to our hospital. Her biliary computed tomography revealed a 28 mm-sized protruding solid mass in the proximal common bile duct. The patient underwent left hemihepatectomy with S1 segmentectomy and segmental excision of the common bile duct. Microscopically, the tumor was a moderately differentiated squamous cell carcinoma of the extrahepatic bile duct, without any component of adenocarcinoma or metaplastic portion in the biliary epithelium. Immunohistochemically, the tumor was positive for cytokeratin (CK) 5/6, CK19, p40, and p63. Squamous cell carcinoma of the extrahepatic bile duct is rare. To date, only 24 cases of biliary squamous cell carcinomas have been reported. Here, we provide a clinicopathologic review of previously reported extrahepatic bile duct squamous cell carcinomas.

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Cholangiocarcinoma With Liver Metastasis in Squamous Cell Carcinoma Type: A Case Report
Jane Chiang
Journal of Diagnostic Medical Sonography.2024; 40(6): 609. CrossRef
A Rare Case of Squamous Cell Carcinoma of the Bile Duct
Julianna Tantum, Rachael Schneider, Stefanie Gallagher, Kyley Leroy, Jared Lander, Patricia Wong
ACG Case Reports Journal.2023; 10(8): e01119. CrossRef
Metastatic Anal Squamous Cell Carcinoma Presenting as an Indeterminate Biliary Stricture Diagnosed By Cholangioscopy
Ritu Nahar, Ian Holmes, Jeffrey Baliff, Austin Chiang, Thomas Kowalski
ACG Case Reports Journal.2022; 9(6): e00785. CrossRef
Temporal Changes in Cholangiocarcinoma Incidence and Mortality in the United States from 2001 to 2017
Milind Javle, Sunyoung Lee, Nilofer S Azad, Mitesh J Borad, Robin Kate Kelley, Smitha Sivaraman, Anna Teschemaker, Ishveen Chopra, Nora Janjan, Shreekant Parasuraman, Tanios S Bekaii-Saab
The Oncologist.2022; 27(10): 874. CrossRef
PRIMARY SQUAMOUS CELL CARCINOMA OF THE COMMON BILE DUCT WITH LIVER METASTASES
Dhouha BACHA, Mohamed HAJRI, Wael FERJAOUI, Ghofrane TALBI, Lasaad GHARBI, Mohamed Taher KHALFALLAH, Sana ben SLAMA, Ahlem LAHMAR
ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo).2021;[Epub] CrossRef
S1510 A Rare Case of Squamous Cell Carcinoma of the Bile Duct
Stefanie Gallagher, Kyley Leroy, Julianna Tantum, Babak Etemad
American Journal of Gastroenterology.2021; 116(1): S688. CrossRef
Heparin

Reactions Weekly.2019; 1752(1): 184. CrossRef
Carcinoma primario de células escamosas del conducto hepático común: a propósito de un caso
Ana Delgado Maroto, Andrés Barrientos Delgado, Marta Lázaro Sáez, Samia Hallouch Toutouh, Enrique Práxedes González
Gastroenterología y Hepatología.2019; 42(7): 436. CrossRef
Primary squamous cell carcinoma of the extrahepatic bile duct: A case report
Ana Delgado Maroto, Andrés Barrientos Delgado, Marta Lázaro Sáez, Samia Hallouch Toutouh, Enrique Práxedes González
Gastroenterología y Hepatología (English Edition).2019; 42(7): 436. CrossRef

Recurrent Indeterminate Dendritic Cell Tumor of the Skin: Jin Woo Joo, Taek Chung, Yoon Ah Cho, Sang Kyum Kim; J Pathol Transl Med. 2018;52(4):243-247. Published online April 5, 2018; DOI: https://doi.org/10.4132/jptm.2018.03.27

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Abstract PDF

Indeterminate dendritic cell tumor (IDCT) is a dendritic cell tumor that displays histologic features similar to those of Langerhans cells. The origin of the indeterminate cells may represent precursors of Langerhans cells or skin dendritic cells. IDCT is extremely rare, and tumor progression and predictive factors are not well known. Here, we report a case of a 61-year-old man who presented with a papule on his back and was finally diagnosed with IDCT based on histology and immunohistochemistry. The tumor recurred three months after surgical excision.

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Pathologic characteristics of histiocytic and dendritic cell neoplasms
Sun Och Yoon
Blood Research.2024;[Epub] CrossRef
Indeterminate cell histiocytosis: A systematic review of the literature with a comprehensive revision of clinical, histopathological, and molecular features
Simone Zanella, Emilio Berti, Arturo Bonometti
Journal of the European Academy of Dermatology and Venereology.2023; 37(8): 1559. CrossRef

Primary Cutaneous Mucinous Carcinoma with Extramammary Paget’s Disease: Eccrine or Apocrine?: Sun-Ju Oh, Young-Ok Kim; J Pathol Transl Med. 2018;52(4):238-242. Published online January 25, 2018; DOI: https://doi.org/10.4132/jptm.2017.11.21

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Abstract PDF

Primary cutaneous mucinous carcinoma (PCMC) is an uncommon tumor of the sweat gland origin. The occurrence of PCMC is mostly in middle-aged and older patients, with a slight male predominance. Most cases of PCMC arise on the head, with a preference for eyelids. The histogenesis of PCMC, whether eccrine or apocrine, remains controversial. We report a rare case of PCMC with secondary extramammary Paget’s disease in the groin of a 75-year-old man, which favored an apocrine origin. Furthermore, based on a review of the literature, we provide several histologic clues that can be used to differentiate PCMC from metastatic mucinous carcinoma.

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Primary cutaneous mucinous carcinoma of the scalp masquerading as a benign dermatological mass – A case report
Fadi Alnehlaoui, Nafad Mohamed Lotfy Elhadidi, Shafik Fwakhrji, Shekhar V. Shikare, Majid Hassan Alhammadi, Salman Yousuf Guraya
International Journal of Surgery Case Reports.2024; 114: 109175. CrossRef
Primary cutaneous mucinous carcinoma in a periorbital lesion: two case reports and literature review
Jun Woo Kim, Sung Eun Kim
Archives of Craniofacial Surgery.2024; 25(2): 90. CrossRef
Primary Cutaneous Mucinous Carcinoma: A Review of the Literature
Timothy Freeman, Aaron J. Russell, M. Laurin Council
Dermatologic Surgery.2023; 49(12): 1091. CrossRef
A Case of Eccrine Mucinous Carcinoma Involving Scalp
Ramsha Saleem, Sachin Vaidya
Cureus.2021;[Epub] CrossRef

Original Article

CD99 Is Strongly Expressed in Basal Cells of the Normal Adult Epidermis and Some Subpopulations of Appendages: Comparison with Developing Fetal Skin: Gawon Choi, Jin Roh, Chan-Sik Park; J Pathol Transl Med. 2016;50(5):361-368. Published online August 7, 2016; DOI: https://doi.org/10.4132/jptm.2016.06.19

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Abstract PDF

Background
CD99 is a cell surface transmembrane glycoprotein expressed in various tissues. CD99 is differentially expressed between subpopulations of each tissue and is highly expressed in certain hematopoietic and precursor cells. However, there has been no comprehensive study of CD99 expression in normal skin. We evaluated CD99 expression in normal human skin and developing fetal skin.
Methods
Seventy-five adult skin samples containing normal skin and eight fetal skin samples of different gestational ages were collected. CD99 immunohistochemical staining was performed to evaluate expression pattern in adult and fetal skin samples. CD99 and CD34 expression were compared by double immunofluorescence.
Results
In normal adult skin, CD99 was strongly expressed in the membrane of epidermal basal keratinocytes, hair follicle bulges and outer root sheaths, and inner secretory cells of eccrine sweat glands. In fetal skin, CD99 was not expressed on the periderm at 16 weeks of gestation but was expressed in basal cells of fetal skin at around 19 weeks of gestation. CD99 expression became comparable to that of the adult skin after 20 weeks of gestation. CD99 and CD34 were co-expressed in hair follicle outer root sheaths, as seen by double immunofluorescence study.
Conclusions
This is the first study examining CD99 expression pattern in normal adult and fetal skin. CD99 tends to be expressed in the basal/precursor cells of epidermis and in hair follicles. These results provide a basis for future investigation on functions of CD99 in the skin and provide a novel potential target for the treatment of dermatologic lesions.

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Childhood pilomatrixoma mimicking malignant small round blue cell tumor with positivity for CD99: Potential pitfall in cytology
Brijdeep Singh, Radhika Srinivasan, Deepak Bansal, Manish Rohilla, Pranab Dey, Uma Nahar Saikia, Ritambhra Nada
Diagnostic Cytopathology.2023;[Epub] CrossRef
Role of CD99 in regulating homeostasis and differentiation in normal human epidermal keratinocytes
Yi Li Wong, Toru Okubo, Eiko Uno, Kazuma Suda, Tsuyoshi Ishii
Biochemical and Biophysical Research Communications.2022; 606: 108. CrossRef
Anti-human CD99 antibody exerts potent antitumor effects in mantle cell lymphoma
Nuchjira Takheaw, Gunya Sittithumcharee, Ryusho Kariya, Watchara Kasinrerk, Seiji Okada
Cancer Immunology, Immunotherapy.2021; 70(6): 1557. CrossRef
“Neuroectodermal influence of CD 99 immunoexpression correlates with the clinical behavior of odontogenic cysts and tumors”
Harshi Mishra, Nikita Gulati, Anshi Jain, Saurabh Juneja, Devi Charan Shetty
Journal of Oral and Maxillofacial Pathology.2021; 25(3): 423. CrossRef
CD99 at the crossroads of physiology and pathology
Michela Pasello, Maria Cristina Manara, Katia Scotlandi
Journal of Cell Communication and Signaling.2018; 12(1): 55. CrossRef
CD99: A Cell Surface Protein with an Oncojanus Role in Tumors
Maria Manara, Michela Pasello, Katia Scotlandi
Genes.2018; 9(3): 159. CrossRef

Case Reports

Squamoid Eccrine Ductal Carcinoma of the Scalp: Yong-Han Jung, Hye-Jung Jo, Mi-Seon Kang; Korean J Pathol. 2012;46(3):278-281. Published online June 22, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.3.278

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Abstract PDF

Squamoid eccrine ductal carcinoma (SEDC) is an exceedingly rare tumor that shows both squamous and adnexal ductal differentiation. We report a case of this unusual tumor occurring on the occiput of a 53-year-old man. A histopathological examination revealed a nodular lesion infiltrating the dermis and subcutaneous tissue with numerous duct-like structure and squamoid differentiation foci. Five months later, the patient presented with a palpable mass at the site of the previous excision and the right side of the neck. Sono-guided fine needle aspiration of the right neck mass was performed and was diagnosed as a metastastasis of a lymph node. A right neck node dissection and re-excision of the occiput was performed. The histopathological findings were similar, but squamoid differentiation was more prominent than that in the previous lesion. Because of the rarity of SEDC, little is known about its biological behavior and optimal treatment.

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Squamoid Eccrine Ductal Carcinoma: Treatment and Outcomes
Megan M. Lim, Jillian A. Macdonald
The American Journal of Dermatopathology.2022; 44(4): 249. CrossRef
Recurrent Squamoid Eccrine Ductal Carcinoma After Mohs Micrographic Surgery
Cardwell Gavin, Brinker Alyson
Dermatologic Surgery.2021; 47(8): 1108. CrossRef
Carcinoma ecrino: dos casos de una neoplasia inusual y revisión de la literatura
Clara Matas-Nadal, Josep Manel Fernández-Armenteros, Felip Vilardell, Josep Manel Casanova, Rafael S. Aguayo Ortiz
Piel.2020; 35(3): 159. CrossRef
Squamoid eccrine ductal carcinoma: a case report
Zeynep BAYRAMOĞLU, Betül ÜNAL
The European Research Journal.2020; 6(2): 173. CrossRef
Squamoid eccrine ductal carcinoma of the ear helix
Sunmin Yim, Yun Ho Lee, Seoung Wan Chae, Won‐Serk Kim
Clinical Case Reports.2019; 7(7): 1409. CrossRef
Squamoid eccrine ductal carcinoma of the scalp
Hsien Chan, Vicki Howard, Denis Moir, Delwyn Dyall‐Smith
Australasian Journal of Dermatology.2016;[Epub] CrossRef
Squamoid Eccrine Ductal Carcinoma
Michiel P.J. van der Horst, Adriana Garcia-Herrera, Dorota Markiewicz, Blanca Martin, Eduardo Calonje, Thomas Brenn
American Journal of Surgical Pathology.2016; 40(6): 755. CrossRef
Squamoid eccrine ductal carcinoma
Maria Isabel Ramos Saraiva, Marcella Amaral Horta Barbosa Vieira, Larissa Karine Leite Portocarrero, Rafael Cavanellas Fraga, Priscila Kakizaki, Neusa Yuriko Sakai Valente
Anais Brasileiros de Dermatologia.2016; 91(6): 799. CrossRef
Anatomoclinical study of 30 cases of sclerosing sweat duct carcinomas (microcystic adnexal carcinoma, syringomatous carcinoma and squamoid eccrine ductal carcinoma)
E. Frouin, M.D. Vignon‐Pennamen, B. Balme, B. Cavelier‐Balloy, U. Zimmermann, N. Ortonne, A. Carlotti, L. Pinquier, J. André, B. Cribier
Journal of the European Academy of Dermatology and Venereology.2015; 29(10): 1978. CrossRef

A Cutaneous Myoepithelial Carcinoma Arising in a Papillary Eccrine Adenoma.: Ji Han Jung, Soyoung Im, Seok Jin Kang, Gyong Moon Kim, Ki Taik Han, Jin Young Yoo, Chang Suk Kang; Korean J Pathol. 2011;45(6):644-649.; DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.6.644

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Abstract PDF

Cutaneous myoepithelial neoplasms and papillary eccrine adenomas (PEA) are rare conditions. Malignant tumors within a PEA are even rarer, with only one case reported to date. Herein, we present an extremely rare case of a cutaneous myoepithelial carcinoma arising in a PEA in a 70-year-old man presenting a solid mass in the left buttock. Histopathologically, most of the resected tumor revealed features consistent with the diagnosis of PEA. Some small nests and nodules were intermixed with the PEA and were present adjacent to the PEA. The tumor cells of nests and nodules showed ovoid to spindle shaped nuclei and slightly eosinophilic cytoplasm. Immunohistochemically, they were positive for both epithelial and myogenic markers, consistent with myoepithelioma. An inguinal lymph node with a metastatic lesion showed the same findings of myoepithelioma despite inconspicuous atypia. Our case showed malignant transformation of the myoepithelial cells at the outermost layers of the PEA.

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Papillary eccrine adenoma associated with syringocystadenoma papilliferum
Neha Meena, PrafullaKumar Sharma, Sawan Kumar, Minakshi Bhardwaj
Indian Journal of Dermatology, Venereology and Leprology.2018; 84(3): 322. CrossRef
Pleural fluid metastases of myoepithelial carcinoma: A case report and review of the literature
Alicia Calderon Bhambra, Yanhong Zhang, Eric C. Huang, John Bishop, Mahan Matin, Alaa Afify
CytoJournal.2016; 13: 13. CrossRef

Sporadic Cutaneous Keratocyst without Nevoid Basal Cell Carcinoma Syndrome: Report of 1 Case.: Hye Won Lee, Ji Young Park, Sun Hee Kang, Misun Choe; Korean J Pathol. 2011;45(3):322-325.; DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.3.322

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Abstract PDF

A cutaneous keratocyst is very rare and is ordinarily associated with nevoid basal cell carcinoma syndrome (NBCCS), also known as Gorlin syndrome. NBCCS is a rare autosomal-dominant disorder that results from the mutation in the patched homologue 1 (PTCH1) gene located on chromosome 9q22.3, with high penetrance and variable expressivity. NBCCS demonstrates multisystem manifestations such as multiple basal cell carcinomas in early age, jaw cysts and pits of the hands and feet. Cutaneous keratocysts are characteristically lined by festooned keratinized squamous epithelium with parakeratosis. The cystic wall contains neither granular cell layer nor skin appendages. To the best of our knowledge, only two cases of cutaneous keratocysts not associated with NBCCS have been reported to date. We report one another case of a histologically confirmed cutaneous keratocyst in a 50-year-old female without a family history and clinical features of NBCCS.

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Sporadic Cutaneous Keratocyst of the Scalp: A Report of an Extremely Rare Lesion
Rana S AL-Zaidi, Eyad Tantawi, Rahaf AL-Radadi, Asrar Banjar
Cureus.2021;[Epub] CrossRef
A Large Extragnathic Keratocystic Odontogenic Tumour
Soumya Makarla, Radhika M. Bavle, Sudhakara Muniswamappa, Srinath Narasimhamurthy
Case Reports in Pathology.2015; 2015: 1. CrossRef

Adnexal Clear Cell Carcinoma with Comedonecrosis: A Case Report.: Seo Hee Kim, Sun Hee Han, Jung Suk An, Ju Han Lee, Eung Seok Lee, Heum Rye Park, Young Sik Kim; Korean J Pathol. 2010;44(1):92-96.; DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.1.92

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Abstract PDF

Adnexal clear cell carcinoma with comedonecrosis (ACCCC) is a very rare malignancy of the skin with an aggressive clinical course and a predilection for the scalp. This is the first reported case of ACCCC in Korea. A 79-year-old male presented with left abdominal masses that proved to be two subcutaneous nodules. The tumors histologically consisted of epithelial nests that showed a distinctive zonal arrangement. The centrally located clear cell areas with comedonecroses were merged with the peripheral squamoid cells, often exhibiting retraction artifacts and an infiltrating border. Nuclear pleomorphism and frequent mitoses were prominent. The clear cells were immunopositive for carcinoembryonic antigen and epithelial membrane antigen. We report here on a case of ACCCC involving the abdominal skin, and this tumor should be distinguished from the more indolent squamous cell and tricholemmal carcinomas.

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Adnexal Clear Cell Carcinoma Exhibiting Comedonecrosis of the Ear: A Rare Case Treated With Mohs Micrographic Surgery
Helen Z Chen, Mohamad Jabin, Michelle Tarbox, Russell Akin, Ashley Sturgeon
Cureus.2024;[Epub] CrossRef

Original Article

Alteration of G1/S Cell Cycle Regulatory Proteins in Carcinogenesis of Cutaneous Squamous Cell Carcinomas.: Soyoung Im, Changyoung Yoo, Ji Han Jung, Hyun Joo Choi, Jinyoung Yoo, Seok Jin Kang, Kyo Young Lee; Korean J Pathol. 2009;43(6):542-549.; DOI: https://doi.org/10.4132/KoreanJPathol.2009.43.6.542

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Abstract PDF

BACKGROUND
Aberration of the cell cycle regulatory proteins has been reported to contribute to the development and progression of human malignancy. We studied the expression of G1/S cell cycle regulatory proteins to investigate the carcinogenesis in cutaneous squamous cell lesions. METHODS: We evaluated the expressions of p16, pRb, cyclin D1 and Ki-67 protein by immunonohistochemistry in cases of normal skin (n=15), seborrheic keratosis (SK; n=26), actinic keratosis (AK; n=30), Bowen's disease (BD; n=37), keratoacanthoma (KA; n=23), and squamous cell carcinoma (SCC; n=22). RESULTS: The Ki-67 expression gradually increased from SK, through AK, to BD. The expression of p16 was more increased in BD than that in AK. The decreased expressions of p16 and Rb, and the increased expression of cyclin D1 were observed to a greater degree in SCC than those in BD. The expressions of cyclin D1 and Ki-67 were higher in SCC than those in KA. CONCLUSIONS: The altered expressions of p16, Rb, and cyclin D1 were considered to be related to the carcinogenesis in the cutaneous squamous cell lesions. Therefore, immunohistochemical studies of the cell cycle regulatory proteins and a combined analysis may be helpful as an adjunct to the histomorphology in the diagnosis of cutaneous squamous cell lesions.

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Expression of pRb, p53, p16 and Cyclin D1 and Their Clinical Implications in Urothelial Carcinoma
Kyungji Lee, Eun Sun Jung, Young-Jin Choi, Kyo Young Lee, Ahwon Lee
Journal of Korean Medical Science.2010; 25(10): 1449. CrossRef

Case Reports

Cutaneous Ciliated Cyst: Report of a case.: Eundeok Chang, Sangin Shim; Korean J Pathol. 1995;29(3):391-392.

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Abstract PDF: Farmer and Helwig coined the term cutaneous ciliated cyst in 1978 to describe specific skin cysts lined with ciliated epithelium a resembling the mucosa of the fallopian tube. Twenty case, of cutaneous ciliated cysts have been published to date. All have been found to affect the lower limb and all patients have been women. The etiology of the cyst is as yet unknown. A 37-year-old woman had a cyst excised from the left buttock. Microscopically, the lining epithelium of the cyst wall was composed of columnar cilited cells similar to those seen in the fallopian tubes. Immunoperoxidase stainings for cytokeratin, epithelial membrane antigen and carcinoembryonic antigen were positive.

Malignant Small Cell Tumor of the Thoracopulmonary Region (Askin Tumor): Report of a case.: Young Im Han, Hye Jin Lee, Kang Suek Suh, Sun Kyung Lee; Korean J Pathol. 1995;29(5):687-690.

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Abstract: Malignant small cell tumor(MSCT) of the thoracopulmonary region(Askin tumor) is extremely rare and is seen predominantly in children and adolescents. This tumor represents a distinct clinicopathologic entity of neuroectodertnal origin, arising from the soft tissues of the chest wall or peripheral lung. This tumor tends to recur locally, but does not seem to disseminate widely. The overall survival is poor. Recently, we experienced a case of the MSCT of the thoracopulmonary region of a 12-year-old female. She was admitted because of a chest wall mass on radiographic examination, and a complaint of intermittent chest pain. Grossly, the mass was lobulated, round and had a solid appearance with focal necrosis and hemorrhage on the cut surface. Histologically, small round to oval cells were arranged in compact sheets, nests and lobular patterns with intervening fibrovascular stroma. Ultrastructurally, the presence of loose-fitting membrane-bound neurosecretory granules was noted.

Sebaceous Trichofolliculoma: A case report.: Jeana Kim, Seong Beom Lee, Seok Jin Kang, Soo Il Chung, Sun Moo Kim; Korean J Pathol. 1995;29(6):794-796.

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Abstract PDF: Sebaceous trichofolliculoma is a variant of trichofolliculoma which occurs in the sebaceous areas rich in follicles and is a relatively rare skin tumor. This tumor is a clinically and histologically easy tumor to recognize that is well differentiated. We examined a case of a consists of a 21-year-old female who had a pedunculated nodule on her scalp. Microscopically, the tumor was large, had a centrally located cavity lined by squamous epithelium and radially arranged sebaceous follicles connected to the cavity. No cytological atypia or recurrence after excision was found.

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