Fig. 1Histologic and immunologic features of molecular apocrine breast cancer (MABC). It shows abundant granular eosinophilic cytoplasm, cytoplasmic vacuolization and vesicular nuclei with prominent nucleoli on histology (A). It is negative for estrogen receptor (B), but is also frequently positive for human epidermal growth factor receptor 2 (C), androgen receptor (D) and gamma-glutamyltrasferase 1 (E). The expression of basal markers such as epidermal growth factor receptor (F) and cytokeratin 5/6 (G) is also occasionally seen in cases of MABC.
Fig. 2Disease-free survival and overall survival depending on the phenotypes of breast cancer. MABC, molecular apocrine breast cancer.
Fig. 3The prognostic value of the expression of human epidermal growth factor receptor 2 (HER-2) and basal markers in cases of molecular apocrine breast cancer.
Table 1Clone, dilution, and source of antibodies
Table 2Clinicopathologic characteristics of patients according to the molecular subtype of breast cancer
Table 3Clinicopathologic characteristics of patients according to breast cancer phenotype
Table 4Correlation between molecular subtype and tumor phenotype