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Volume 46(2); April 2012
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Original Articles
Clinicopathologic Features of IgA-Dominant Postinfectious Glomerulonephritis
Tai Yeon Koo, Gheun-Ho Kim, Moon Hyang Park
Korean J Pathol. 2012;46(2):105-114.   Published online April 25, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.2.105
  • 9,438 View
  • 100 Download
  • 10 Citations
AbstractAbstract PDF
Background

IgA-dominant acute postinfectious glomerulonephritis (APIGN) is a recently recognized morphologic variant of APIGN, but its clinicopathologic features were not clearly characterized. We will present demographic, clinical and renal biopsy findings from seven patients with IgA-dominant APIGN with a literature review.

Methods

All renal biopsy specimens (n=1,119) processed by the Department of Pathology in Hanyang University Hospital from 2005 to 2009 were reviewed. Seven patients with IgA-dominant APIGN were identified, and their clinical data analyzed.

Results

All patients had renal failure, hematuria and proteinuria. One was diabetic, and none of the patients had previous renal diseases. Three had clinical infections at the time of presentation: 2 with methicillin-resistant Staphylococcus aureus and one with rickettsial infection. Light microscopically diffuse endocapillary proliferative and exudative glomerulonephritis was found in all cases. Immunofluorescence microscopy showed granular IgA deposits along peripheral capillary walls and in mesangium. Ultrastructurally, subepithelial 'humps' with mesangial deposits were noted. End-stage renal disease developed in two patients, chronic renal failure was stationary in two, and azotemia improved in three.

Conclusions

Various infections including rickettsiosis preceded IgA-dominant APIGN in both diabetics and nondiabetics. Because the prognosis of IgA-dominant APIGN is poor, early diagnosis based on renal biopsy is required.

Citations

Citations to this article as recorded by  
  • Staphylococcus aureus Infection-Related Glomerulonephritis with Dominant IgA Deposition
    Mamiko Takayasu, Kouichi Hirayama, Homare Shimohata, Masaki Kobayashi, Akio Koyama
    International Journal of Molecular Sciences.2022; 23(13): 7482.     CrossRef
  • IgA-Dominant Infection-Associated Glomerulonephritis Following SARS-CoV-2 Infection
    Aurora Pérez, Isidro Torregrosa, Luis D’Marco, Isabel Juan, Liria Terradez, Miguel Ángel Solís, Francesc Moncho, Carmen Carda-Batalla, María J. Forner, Jose Luis Gorriz
    Viruses.2021; 13(4): 587.     CrossRef
  • Relationship between blood neutrophil‐lymphocyte ratio and renal tubular atrophy/interstitial fibrosis in IgA nephropathy patients
    Lingxiong Chai, Kedan Cai, Kaiyue Wang, Qun Luo
    Journal of Clinical Laboratory Analysis.2021;[Epub]     CrossRef
  • The Continuing Need for Electron Microscopy in Examination of Medical Renal Biopsies: Examples in Practice
    Michifumi Yamashita, Mercury Y. Lin, Jean Hou, Kevin Y.M. Ren, Mark Haas
    Glomerular Diseases.2021; 1(3): 145.     CrossRef
  • Clinicopathologic features of infection-related glomerulonephritis with IgA deposits: a French Nationwide study
    Elodie Miquelestorena-Standley, Charlotte Jaulerry, Marie-Christine Machet, Nolwenn Rabot, Christelle Barbet, Aurélie Hummel, Alexandre Karras, Cyril Garrouste, Thomas Crepin, Didier Ducloux, Maud Cousin, Catherine Albert, Joseph Rivalan, Emilie Cornec-Le
    Diagnostic Pathology.2020;[Epub]     CrossRef
  • IgA nephropathy and infections
    Cristiana Rollino, Gisella Vischini, Rosanna Coppo
    Journal of Nephrology.2016; 29(4): 463.     CrossRef
  • <i>Staphylococcus</i>-associated Glomerulonephritis
    Dong Yeol Shin, Sung Han Kim, Ji Wan Lee, Ki Ju Chang, Seung Ha Hwang, Yong Mee Cho, Soon Bae Kim
    The Korean Journal of Medicine.2016; 90(2): 148.     CrossRef
  • Use of steroid therapy in immunoglobulin A-dominant poststaphylococcal glomerulonephritis
    Mahesh Eswarappa, Vijay Varma, K.C. Gurudev
    Hong Kong Journal of Nephrology.2015; 17(2): 46.     CrossRef
  • Clinicopathologic Features of IgA-Dominant Infection-Associated Glomerulonephritis: A Pooled Analysis of 78 Cases
    Ru Bu, Qian Li, Zhi-yu Duan, Jie Wu, Pu Chen, Xiang-mei Chen, Guang-yan Cai
    American Journal of Nephrology.2015; 41(2): 98.     CrossRef
  • Garland-pattern postinfectious glomerulonephritis with IgA-dominant deposition
    Makoto Kanno, Kenichi Tanaka, Hiroshi Kimura, Kimio Watanabe, Yoshimitsu Hayashi, Koichi Asahi, Masaaki Nakayama, Kensuke Joh, Tsuyoshi Watanabe
    CEN Case Reports.2014; 3(1): 56.     CrossRef
Diagnostic Value of MDM2 and DDIT3 Fluorescence In Situ Hybridization in Liposarcoma Classification: A Single-Institution Experience
Junhun Cho, Seung Eun Lee, Yoon-La Choi
Korean J Pathol. 2012;46(2):115-122.   Published online April 25, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.2.115
  • 7,008 View
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  • 7 Citations
AbstractAbstract PDF
Background

The amplification of murine double minutes (MDM2) is the primary feature of well-differentiated liposarcomas (WDLPS) and dedifferentiated liposarcomas (DDLPS), while DDIT3 rearrangement is the main one of myxoid liposarcomas (MLPS). Our aim was to evaluate the added value of MDM2 amplification and DDIT3 rearrangement in making a diagnosis and classifying lipogenic tumors.

Methods

Eighty-two cases of liposarcoma and 60 lipomas diagnosed between 1995 and 2010 were analysed for MDM2 amplification and DDIT3 rearrangement using a fluorescence in situ hybridization (FISH). The subtypes of liposarcoma were reclassified according to the molecular results, whose results were reviewed with an analysis of the relevant histologic and immunohistochemical findings.

Results

One case of lipoma (1.67%) was reclassified as a WDLPS. Of the liposarcomas, 13.4% (16/82) were reclassified after the molecular testing. Five cases of MLPS were reclassified as four cases of DDLPS and one case of myxoid lipoma. Two cases of WDLPS were reclassified as one case of spindle cell lipoma and another case of myxofibrosarcoma. Four cases of DDLPS were reclassified as two cases of leiomyosarcoma, one case of angiomyolipoma and another case of fibroinflammatory lesion. Of the six cases of pleomorphic liposarcoma, five were reclassified as DDLPS.

Conclusions

In our series, a critical revision of diagnosis was found at a rate of 3.5% (5/142) after a review of the lipomatous lesions. The uses of molecular testing by MDM2 and DDIT3 FISH were valuable to make an accurate subtyping of liposarcomas as well as to differentiate WDLPS from benign lipomatous tumor.

Citations

Citations to this article as recorded by  
  • FISH Diagnostic Assessment of MDM2 Amplification in Liposarcoma: Potential Pitfalls and Troubleshooting Recommendations
    Alessandro Gambella, Luca Bertero, Milena Rondón-Lagos, Ludovica Verdun Di Cantogno, Nelson Rangel, Chiara Pitino, Alessia Andrea Ricci, Luca Mangherini, Isabella Castellano, Paola Cassoni
    International Journal of Molecular Sciences.2023; 24(2): 1342.     CrossRef
  • Expression of CTAG1B clone EPR13780 versus DDIT3 gene rearrangement distinguishes myxoid liposarcoma from its mimics with detection of novel DDIT3 gene copy number variations
    Marwa M. Abdelaziz, Hanan Y. Tayel, Amany Abdel-Bary, Omnia M. Badawy
    Journal of Histotechnology.2022; 45(2): 56.     CrossRef
  • Musculoskeletal Tumors
    Amit Singla, David S. Geller
    Pediatric Clinics of North America.2020; 67(1): 227.     CrossRef
  • Vulvar Myxoid Liposarcoma, an Extremely Rare Diagnosis
    Ligia Redroban, Nelson Montalvo
    International Journal of Gynecological Pathology.2019; 38(1): 17.     CrossRef
  • Molecular updates in adipocytic neoplasms✰
    Elizabeth G. Demicco
    Seminars in Diagnostic Pathology.2019; 36(2): 85.     CrossRef
  • Application of MDM2 Fluorescence In Situ Hybridization and Immunohistochemistry in Distinguishing Dedifferentiated Liposarcoma From Other High-grade Sarcomas
    Min Jeong Song, Kyung-Ja Cho, Jong-Seok Lee, Joon Seon Song
    Applied Immunohistochemistry & Molecular Morphology.2017; 25(10): 712.     CrossRef
  • FluorescenceIn SituHybridization forMDM2Amplification as a Routine Ancillary Diagnostic Tool for Suspected Well-Differentiated and Dedifferentiated Liposarcomas: Experience at a Tertiary Center
    Khin Thway, Jayson Wang, John Swansbury, Toon Min, Cyril Fisher
    Sarcoma.2015; 2015: 1.     CrossRef
Difference of Genome-Wide Copy Number Alterations between High-Grade Squamous Intraepithelial Lesions and Squamous Cell Carcinomas of the Uterine Cervix
Bum Hee Lee, Sangyoung Roh, Yu Im Kim, Ahwon Lee, Su Young Kim
Korean J Pathol. 2012;46(2):123-130.   Published online April 25, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.2.123
  • 5,790 View
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  • 2 Citations
AbstractAbstract PDF
Background

About 10% of high-grade squamous intraepithelial lesions (HSILs) progress to invasive carcinomas within 2-10 years. By delineating the events that occur in the early stage of the invasion, the pathogenesis of cervical cancer could be better understood. This will also propose the possible methods for inhibiting the tumor invasion and improving the survival of patients.

Methods

We compared the genomic profiles between the HSIL and the invasive squamous cell carcinoma (SCC) using an array comparative genomic hybridization. Using recurrently altered genes, we performed a principal component analysis to see variation of samples in both groups. To find possibly affected pathways by altered genes, we analyzed genomic profiles with the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway database and GOEAST software.

Results

We found 11q12.3 and 2p24.1 regions have recurrent copy number gains in both groups. 16p12-13 and 20q11-13 regions showed an increased copy number only in cases of HSIL. 1q25.3 and 3q23-29 regions showed copy number gains only in cases of SCC. Altered genes in the SCC group were related to the mitogen-activated protein kinase signaling pathway and the RNA transport. Altered genes in the HSIL group were related to the ubiquitin mediated proteolysis and cell adhesion molecules.

Conclusions

Our results showed not only that gains in 11q12.3 and 2p24.1 were early events occurring in the premalignant lesions and then maintained in cases of SCC but also that gains in 1q25.3 and 3q23-29 were late events occurring after invasion in those of SCC.

Citations

Citations to this article as recorded by  
  • Cytokeratin and protein expression patterns in squamous cell carcinoma of the oral cavity provide evidence for two distinct pathogenetic pathways
    GESCHE FROHWITTER, HORST BUERGER, PAUL J. VAN DIEST, EBERHARD KORSCHING, JOHANNES KLEINHEINZ, THOMAS FILLIES
    Oncology Letters.2016; 12(1): 107.     CrossRef
  • 'Drawing' a Molecular Portrait of CIN and Cervical Cancer: a Review of Genome-Wide Molecular Profiling Data
    Olga V Kurmyshkina, Pavel I Kovchur, Tatyana O Volkova
    Asian Pacific Journal of Cancer Prevention.2015; 16(11): 4477.     CrossRef
Markers for Screening Lynch Syndrome Are Reliable and Useful for Identifying the Specimen Mislabeling
Sun-ju Byeon, Jiwoon Choi, Kyung Han Nam, Bo-Gun Jang, Hee Eun Lee, Min A Kim, Woo Ho Kim
Korean J Pathol. 2012;46(2):131-136.   Published online April 25, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.2.131
  • 6,259 View
  • 45 Download
  • 1 Citations
AbstractAbstract PDF
Background

During specimen processing in surgical pathology laboratories, specimen-related adverse events (SRAEs), such as mislabeling and specimen mixed-up might occur. In these situations, molecular techniques using short tandem repeat (STR) loci are required to identify the personal identity. Microsatellite instability (MSI) test is widely used for screening the hereditary non-polyposis colon cancer (Lynch syndrome) in surgical pathologies using polymorphic STR markers. We tried to evaluate the applicability of the MSI test for SRAEs.

Methods

We obtained 253 MSI test results to analyze the allele frequencies. After calibrating the estimated nucleotide lengths, we calculated the allele frequencies, a random match probability, and a likelihood ratio (LR) of three dinucleotide STR markers (D5S349, D17S250, and D2S123).

Results

The distribution of LR was 136.38 to 5,606,213.10. There was no case of LR<100. In addition, there were 153 cases (60.5%) of LR ranging from 100 to 10,000 and 100 cases (39.5%) of LR>10,000. Furthermore, the combined probability of identity was 9.23×10-4 and the combined power of exclusion was 0.99908.

Conclusions

Using the three STR markers that are recommended for MSI test, all the cases were positively identified in 1% range and about one-third cases showed high LR (>10,000). These results showed that MSI tests are useful to screen the personal identity in case of SRAE in pathology laboratories.

Citations

Citations to this article as recorded by  
  • Sensitivity and polymorphism of Bethesda panel markers in Chinese population
    Yanying Zheng, Jie Chen, Xiang Zhang, Ling Xie, Yifen Zhang, Yi Sun
    Bulletin du Cancer.2020; 107(11): 1091.     CrossRef
Significance of Electron Dense Deposits in Patients with Minimal Change Nephrotic Syndrome
Sae Yoon Kim, Sang Su Lee, Myoung Uk Kim, Jae Min Lee, Seok Jeong Kang, Yong Jin Kim, Yong Hoon Park
Korean J Pathol. 2012;46(2):137-141.   Published online April 25, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.2.137
  • 4,960 View
  • 34 Download
AbstractAbstract PDF
Background

Minimal change nephritic syndrome (MCNS) is characterized by a lack of obvious abnormalities on light microscopy, but its electron microscopic findings include the negative immunofluorescence findings and the diffuse effacement of the epithelial cell foot processes. Rarely the presence of electron dense deposits (EDDs) has been reported, but its clinical significance remains obscure.

Methods

Eleven patients with MCNS who had the EDD deposited were enrolled in the current study. We compared the clinical characteristics, laboratory results and response to steroid treatment between the two group: the EDD group (n=11; the male-to-female ratio, 8:3) and the non-EDD group (n=13, 8:5).

Results

There were no significant differences in most of the laboratory results or response to steroid treatment between the two groups. The frequency of relapses per year was significantly higher in the EDD group (1.1±0.7 times vs. 0.5±0.6 times; p=0.023). These EDDs were found in the mesangium or paramesangium. With no respect to the characteristics of EDDs, our results showed that they did not cause poor treatment outcomes except for the annual frequency of relapse.

Conclusions

Further large-scale studies are warrented to determine the immunologic and prognostic significance of EDDs in patients with MCNS.

Expression of HAT1 and HDAC1, 2, 3 in Diffuse Large B-Cell Lymphomas, Peripheral T-Cell Lymphomas, and NK/T-Cell Lymphomas
Soo Kee Min, Young Ho Koh, Yunwoong Park, Hyo Jung Kim, Jinwon Seo, Hye-Rim Park, Seong Jin Cho, In Sun Kim
Korean J Pathol. 2012;46(2):142-150.   Published online April 25, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.2.142
  • 6,078 View
  • 60 Download
  • 18 Citations
AbstractAbstract PDF
Background

It has generally been proven that histone acetylation and deacetylation are involved in the malignant transformation. To date, however, this has rarely been studied in cases of malignant lymphoma.

Methods

We studied nine cases of reactive lymphoid hyperplasia, 78 cases of diffuse large B-cell lymphoma (DLBCL), 13 cases of peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), and 13 cases of extranodal NK/T-cell lymphoma, nasal type (NKTCL). Thus, we attempted to elucidate the associations of the degree of the expression of histone acetyltransferase 1 (HAT1), histone deacetylase (HDAC) 1, HDAC2, and HDAC3 with the clinical behaviors of above malignant lymphomas using the immunohistochemistry and a western blot analysis.

Results

The degree of the expression of HAT1 was higher in cases of DLBCL, PTCL-NOS or NKTCL as compared with reactive lymphoid hyperplasia (p<0.05). The degree of the expression of HAT1 was correlated with that of HDAC1 in cases of DLBCL or NKTCL (p<0.05). The degree of the expression of HAT1 and HDAC1 was correlated with a poor survival in cases of DLBCL or PTCL-NOS (p>0.05).

Conclusions

HAT1, HDAC1, and HDAC2 play a critical role in the development of malignant lymphomas. Both HAT1 and HDAC1 might be indicators for a poor prognosis in cases of DLBCL as cooperating factors.

Citations

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  • Potential Therapeutic Use of Aptamers against HAT1 in Lung Cancer
    José Ignacio Klett-Mingo, Celia Pinto-Díez, Julio Cambronero-Plaza, Rebeca Carrión-Marchante, Miriam Barragán-Usero, María Isabel Pérez-Morgado, Eulalia Rodríguez-Martín, Mª Val Toledo-Lobo, Víctor M González, M. Elena Martín
    Cancers.2022; 15(1): 227.     CrossRef
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    Bárbara Matos, John Howl, Carmen Jerónimo, Margarida Fardilha
    Drug Discovery Today.2021; 26(11): 2680.     CrossRef
  • Histone acetyltransferase 1 promotes gemcitabine resistance by regulating the PVT1/EZH2 complex in pancreatic cancer
    Yan Sun, Dianyun Ren, Yingke Zhou, Jian Shen, Heshui Wu, Xin Jin
    Cell Death & Disease.2021;[Epub]     CrossRef
  • Deciphering genes associated with diffuse large B-cell lymphoma with lymphomatous effusions: A mutational accumulation scoring approach
    Sina Abdollahi, Seyedeh Zahra Dehghanian, Liang-Yi Hung, Shiang-Jie Yang, Dao-Peng Chen, L. Jeffrey Medeiros, Jung-Hsien Chiang, Kung-Chao Chang
    Biomarker Research.2021;[Epub]     CrossRef
  • The contributory roles of histone deacetylases (HDACs) in hematopoiesis regulation and possibilities for pharmacologic interventions in hematologic malignancies
    Mahdieh Mehrpouri, Atieh Pourbagheri-Sigaroodi, Davood Bashash
    International Immunopharmacology.2021; 100: 108114.     CrossRef
  • Emerging role of histone deacetylase inhibitors in the treatment of diffuse large B-cell lymphoma
    Mingyang Wang, Xiaosheng Fang, Xin Wang
    Leukemia & Lymphoma.2020; 61(4): 763.     CrossRef
  • Effective Treatment with PD-1 Antibody, Chidamide, Etoposide, and Thalidomide (PCET) for Relapsed/Refractory Natural Killer/T-Cell Lymphoma: A Report of Three Cases


    Lijun Du, Lei Zhang, Ling Li, Xin Li, Jiaqin Yan, Xinhua Wang, Xiaorui Fu, Zhenchang Sun, Xudong Zhang, Zhaoming Li, Jingjing Wu, Hui Yu, Yu Chang, Zhiyuan Zhou, Feifei Nan, Xiaolong Wu, Li Tian, Mingzhi Zhang
    OncoTargets and Therapy.2020; Volume 13: 7189.     CrossRef
  • Overexpressed histone acetyltransferase 1 regulates cancer immunity by increasing programmed death-ligand 1 expression in pancreatic cancer
    Ping Fan, Jingyuan Zhao, Zibo Meng, Heyu Wu, Bo Wang, Heshui Wu, Xin Jin
    Journal of Experimental & Clinical Cancer Research.2019;[Epub]     CrossRef
  • Histone modifications: A review about the presence of this epigenetic phenomenon in carcinogenesis
    Emanuely Silva Chrun, Filipe Modolo, Filipe Ivan Daniel
    Pathology - Research and Practice.2017; 213(11): 1329.     CrossRef
  • Histone Acetyltransferase 1 Promotes Cell Proliferation and Induces Cisplatin Resistance in Hepatocellular Carcinoma
    Xin Jin, Shenghua Tian, Pingping Li
    Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics.2017; 25(6): 939.     CrossRef
  • HDACs and HDAC Inhibitors in Cancer Development and Therapy
    Yixuan Li, Edward Seto
    Cold Spring Harbor Perspectives in Medicine.2016; 6(10): a026831.     CrossRef
  • Histone deacetylase inhibitors and epigenetic regulation in lymphoid malignancies
    Diana Markozashvili, Vincent Ribrag, Yegor S. Vassetzky
    Investigational New Drugs.2015; 33(6): 1280.     CrossRef
  • Genome-Wide Association Study of Event-Free Survival in Diffuse Large B-Cell Lymphoma Treated With Immunochemotherapy
    Hervé Ghesquieres, Susan L. Slager, Fabrice Jardin, Amelie S. Veron, Yan W. Asmann, Matthew J. Maurer, Thierry Fest, Thomas M. Habermann, Marie C. Bene, Anne J. Novak, Sylvain Mareschal, Corinne Haioun, Thierry Lamy, Stephen M. Ansell, Herve Tilly, Thomas
    Journal of Clinical Oncology.2015; 33(33): 3930.     CrossRef
  • Histone deacetylase 2 controls p53 and is a critical factor in tumorigenesis
    Tobias Wagner, Peter Brand, Thorsten Heinzel, Oliver H. Krämer
    Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2014; 1846(2): 524.     CrossRef
  • Targetome profiling and functional genetics implicate miR-618 in lymphomagenesis
    Alan Fu, Aaron E Hoffman, Ran Liu, Daniel I Jacobs, Tongzhang Zheng, Yong Zhu
    Epigenetics.2014; 9(5): 730.     CrossRef
  • Expression of Histone Deacetylases HDAC1, HDAC2, HDAC3, and HDAC6 in Invasive Ductal Carcinomas of the Breast
    Jinwon Seo, Soo Kee Min, Hye-Rim Park, Dong Hoon Kim, Mi Jung Kwon, Lee Su Kim, Young-Su Ju
    Journal of Breast Cancer.2014; 17(4): 323.     CrossRef
  • Diffuse large B-cell lymphoma
    Maurizio Martelli, Andrés J.M. Ferreri, Claudio Agostinelli, Alice Di Rocco, Michael Pfreundschuh, Stefano A. Pileri
    Critical Reviews in Oncology/Hematology.2013; 87(2): 146.     CrossRef
  • Histone deacetylase inhibitors activate CIITA and MHC class II antigen expression in diffuse large B-cell lymphoma
    Kelly A. Cycon, Kathleen Mulvaney, Lisa M. Rimsza, Daniel Persky, Shawn P. Murphy
    Immunology.2013; 140(2): 259.     CrossRef
Evaluation of Bronchiolar and Alveolar Cell Injuries Induced by Short- and Long-term Exposure to Sidestream Smoke
Kun-Young Kwon, Hye-Ra Jung, Ilseon Hwang, Won-Il Choi
Korean J Pathol. 2012;46(2):151-161.   Published online April 25, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.2.151
  • 6,646 View
  • 35 Download
  • 2 Citations
AbstractAbstract PDF
Background

We investigated effects of short- and long-term exposure to sidestream smoke on the bronchiolar and alveolar cells in Sprague-Dawley rats.

Methods

Rats were divided into five experimental groups: groups 1, 2, and 3 (1-month exposure to 3, 5, and 7 cigarettes a day, respectively), groups 4 and 5 (3- and 6 month exposure to five cigarettes a day, respectively). We examined the morphologic changes, the expressions of tumor necrosis factor α (TNF-α), tumor growth factor β1 (TGF-β1), interlekin (IL)-1α, IL-1β, Ki-67, and cytokeratin 14 and in situ apoptosis in the bronchiolar and alveolar cells on light microscopy (LM) and electron microscopic (EM) terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining.

Results

LM showed the respiratory bronchiolar dilatation and alveolar wall collapse. In groups 3, 4, and 5, EM showed loss of the cilia and Clara cells with irregular size, more prominent alveolar wall collapse and dilation of alveolar duct than those of groups 1 and 2. Bronchiolar and alveolar cells showed increased expressions of TNF-α and TGF-β in groups 4 and 5. LM and EM TUNEL stains showed increased apoptosis in groups 3, 4, and 5.

Conclusions

Sidestream smoke causes a bronchiolar and alveolar cell injury and the severity correlates strongly the volume and duration of exposure to sidestream smoke.

Citations

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  • Cigarette smoke extract alters the cell cycle via the phospholipid transfer protein/transforming growth factor-β1/CyclinD1/CDK4 pathway
    Xue-Min Chai, You-Lun Li, Hong Chen, Shu-Liang Guo, Li-Li Shui, Ya-Juan Chen
    European Journal of Pharmacology.2016; 786: 85.     CrossRef
  • Keratin-14 Expression in Pneumocytes as a Marker of Lung Regeneration/Repair during Diffuse Alveolar Damage
    Miriam Ficial, Caterina Antonaglia, Marco Chilosi, Mario Santagiuliana, Al-Omoush Tahseen, Davide Confalonieri, Lorenzo Zandonà, Rossana Bussani, Marco Confalonieri
    American Journal of Respiratory and Critical Care Medicine.2014; 189(9): 1142.     CrossRef
Identifying Polymorphisms in IL-31 and Their Association with Susceptibility to Asthma
Ji-In Yu, Weon-Cheol Han, Ki-Jung Yun, Hyung-Bae Moon, Gyung-Jae Oh, Soo-Cheon Chae
Korean J Pathol. 2012;46(2):162-168.   Published online April 25, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.2.162
  • 7,793 View
  • 56 Download
  • 19 Citations
AbstractAbstract PDF
Background

Interleukin 31 (IL-31) is a T helper type 2 effector cytokine that plays an important role in the pathogenesis of atopic and allergic diseases. IL-31 may be involved in promoting allergic inflammation and in inducing airway epithelial responses such as allergic asthma.

Methods

Single-base extension analysis was used to detect the genotypes of IL-31 single nucleotide polymorphisms (SNPs), and we compared the genotype and allele frequencies of the IL-31 SNPs between patients with asthma and healthy controls.

Results

There were no significant differences in the genotype and allele frequencies of the IL-31 SNPs between patients with asthma and healthy controls. Furthermore we compared the genotype and allele frequencies of IL-31 SNPs between patients with atopic asthma, those with non-atopic asthma and healthy controls. This showed that the SNPs were not associated with the susceptibility to atopic asthma. There were no significant differences in the haplotype frequencies of IL-31 SNPs between patients with asthma and healthy controls. In patients with asthma, the IL-31 SNPs were significantly correlated with total serum levels of IgE (p=0.035).

Conclusions

Our results indicate that, the IL-31 SNPs may be associated with IgE production in patients with asthma.

Citations

Citations to this article as recorded by  
  • IL-31: State of the Art for an Inflammation-Oriented Interleukin
    Francesco Borgia, Paolo Custurone, Federica Li Pomi, Raffaele Cordiano, Clara Alessandrello, Sebastiano Gangemi
    International Journal of Molecular Sciences.2022; 23(12): 6507.     CrossRef
  • Interleukin-31 and soluble CD40L: new candidate serum biomarkers that predict therapeutic response in multiple sclerosis
    Isabelle Pastor Bandeira, André Eduardo de Almeida Franzoi, Giulia Murillo Wollmann, Washigton Luiz Gomes de Medeiros Junior, Wesley Nogueira Brandão, Jean Pierre Schatzmann Peron, Jefferson Becker, Osvaldo José Moreira Nascimento, Marcus Vinícius Magno G
    Neurological Sciences.2022; 43(11): 6271.     CrossRef
  • Interleukin‐31: The “itchy” cytokine in inflammation and therapy
    Angeliki Datsi, Martin Steinhoff, Fareed Ahmad, Majid Alam, Joerg Buddenkotte
    Allergy.2021; 76(10): 2982.     CrossRef
  • Infection-Associated Mechanisms of Neuro-Inflammation and Neuro-Immune Crosstalk in Chronic Respiratory Diseases
    Belinda Camp, Sabine Stegemann-Koniszewski, Jens Schreiber
    International Journal of Molecular Sciences.2021; 22(11): 5699.     CrossRef
  • Livestock farm particulate matter enhances airway inflammation in mice with or without allergic airway disease
    Dingyu Liu, James G. Wagner, Jack R. Harkema, Miriam E. Gerlofs-Nijland, Elena Pinelli, Gert Folkerts, Rob J. Vandebriel, Flemming R. Cassee
    World Allergy Organization Journal.2020; 13(4): 100114.     CrossRef
  • IL-31: A new key player in dermatology and beyond
    Işın Sinem Bağci, Thomas Ruzicka
    Journal of Allergy and Clinical Immunology.2018; 141(3): 858.     CrossRef
  • The Role of Interleukin-31 Polymorphisms in Non-Small Cell Lung Cancer Genetic Susceptibility and Clinical Outcome
    Yongfeng Yang, Li Li, Fei Chen, Li Zhang, Hong Bu
    Genetic Testing and Molecular Biomarkers.2018; 22(5): 314.     CrossRef
  • Associations between Interleukin-31 Gene Polymorphisms and Dilated Cardiomyopathy in a Chinese Population
    Huizi Song, Ying Peng, Bin Zhou, Nan Chen, Xiaochuan Xie, Qingyu Dou, Yue Zhong, Li Rao
    Disease Markers.2017; 2017: 1.     CrossRef
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    Hua-Tuo Huang, Jian-Ming Chen, Jing Guo, Yan Lan, Ye-Sheng Wei
    Rheumatology International.2016; 36(6): 799.     CrossRef
  • Stem Cell Factor and Interleukin-31 Expression: Association with IgE among Egyptian Patients with Atopic and Nonatopic Bronchial Asthma
    M. Moaaz, S. Abo El-Nazar, M. Abd El-Rahman, E. Soliman
    Immunological Investigations.2016; 45(2): 87.     CrossRef
  • Interleukin-31 expression and relation to disease severity in human asthma
    Tianwen Lai, Dong Wu, Wen Li, Min Chen, Zhennan Yi, Dan Huang, Zhiliang Jing, Yingying Lü, Quanchao Lv, Dongming Li, Bin Wu
    Scientific Reports.2016;[Epub]     CrossRef
  • Elevated TGF-β1/IL-31 Pathway Is Associated with the Disease Severity of Hepatitis B Virus–Related Liver Cirrhosis
    Desong Ming, Xueping Yu, Ruyi Guo, Yong Deng, Julan Li, Chengzu Lin, Milong Su, Zhenzhong Lin, Zhijun Su
    Viral Immunology.2015; 28(4): 209.     CrossRef
  • Interleukin-31 promotes helper T cell type-2 inflammation in children with allergic rhinitis
    Wenlong Liu, Renzhong Luo, Yanqiu Chen, Changzhi Sun, Jie Wang, Lifeng Zhou, Yan Li, Li Deng
    Pediatric Research.2015; 77(1): 20.     CrossRef
  • The Transforming Growth Factor β1/Interleukin-31 Pathway Is Upregulated in Patients with Hepatitis B Virus-Related Acute-on-Chronic Liver Failure and Is Associated with Disease Severity and Survival
    Xueping Yu, Ruyi Guo, Desong Ming, Yong Deng, Milong Su, Chengzu Lin, Julan Li, Zhenzhong Lin, Zhijun Su, R. L. Hodinka
    Clinical and Vaccine Immunology.2015; 22(5): 484.     CrossRef
  • NFAT1 and JunB Cooperatively Regulate IL-31 Gene Expression in CD4+ T Cells in Health and Disease
    Ji Sun Hwang, Gi-Cheon Kim, EunBee Park, Jung-Eun Kim, Chang-Suk Chae, Won Hwang, Changhon Lee, Sung-Min Hwang, Hui Sun Wang, Chang-Duk Jun, Dipayan Rudra, Sin-Hyeog Im
    The Journal of Immunology.2015; 194(4): 1963.     CrossRef
  • Interleukin-31: A Novel Diagnostic Marker of Allergic Diseases
    Anja Rabenhorst, Karin Hartmann
    Current Allergy and Asthma Reports.2014;[Epub]     CrossRef
  • Role of IL-31 in regulation of Th2 cytokine levels in patients with nasal polyps
    Hong Ouyang, Jie Cheng, Yajun Zheng, Jingdong Du
    European Archives of Oto-Rhino-Laryngology.2014; 271(10): 2703.     CrossRef
  • Polymorphisms of interleukin-31 are associated with anti-CCP levels in females with rheumatoid arthritis
    JI-IN YU, YOUNG-RAN PARK, SHIN-SEOK LEE, SOO-CHEON CHAE
    Journal of Genetics.2014; 93(3): 813.     CrossRef
  • IL-31 Associated with Coronary Artery Lesion Formation in Kawasaki Disease
    Wan-Ning Tseng, Mao-Hung Lo, Mindy Ming-Huey Guo, Kai-Sheng Hsieh, Wei-Chiao Chang, Ho-Chang Kuo, Chien-Sheng Chen
    PLoS ONE.2014; 9(8): e105195.     CrossRef
The Clinicopathologic Features of Molecular Apocrine Breast Cancer
Yoon Jin Cha, Woo-Hee Jung, Ja Seung Koo
Korean J Pathol. 2012;46(2):169-176.   Published online April 25, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.2.169
  • 5,719 View
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  • 12 Citations
AbstractAbstract PDF
Background

To elucidate the clinicopathologic features and their implications on the immunohistochemistry in cases of molecular apocrine breast cancer (MABC).

Methods

Immunohistochemical (IHC) staining for estrogen receptor (ER), human epidermal growth factor receptor 2 (HER-2), cytokeratin (CK) 5/6, epidermal growth factor receptor (EGFR), androgen receptor (AR), gamma-glutamyltrasferase 1 (GGT1) and Ki-67 was performed on tissue microarray breast cancer samples from 204 patients. Phenotypes of breast cancer were divided based on the IHC status of ER, AR and GGT1 into the following: luminal type, ER positive and AR and/or GGT1 positive; basal type, ER, AR, and GGT1 negative; non-basal type, ER positive and AR and GGT1 negative; and MABC type, ER negative and AR and/or GGT1 positive.

Results

In our series of patients (n=204), there were 26 cases of MABC. Besides, there were 18, 60, and 100 cases of luminal type, basal type and non-basal type, respectively. The MABC demonstrated apocrine histology and a higher prevalence of HER-2 positivity than other phenotypes. With the basal type, the MABC manifested a more frequent expression of CK5/6 and EGFR and a higher Ki-67 index than other phenotypes (p<0.001). There were no significant differences in patient prognosis between the phenotypes of breast cancer.

Conclusions

MABC are distinguishable from other phenotypes based on the apocrine histology and a higher expression rate of HER-2.

Citations

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    Burak Ilhan, Selman Emiroğlu, Rustu Türkay, Rıdvan Ilhan
    Current Problems in Cancer.2020; 44(2): 100501.     CrossRef
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    Thomas Grellety
    Bulletin du Cancer.2020; 107(4): 506.     CrossRef
  • Triple‐negative apocrine carcinoma: A rare pathologic subtype with a better prognosis than other triple‐negative breast cancers
    Cletus A. Arciero, Albert H. Diehl, Yuan Liu, Qin Sun, Theresa Gillespie, Xiaoxian Li, Preeti Subhedar
    Journal of Surgical Oncology.2020; 122(6): 1232.     CrossRef
  • Apocrine lesions of the breast: part 2 of a two-part review. Invasive apocrine carcinoma, the molecular apocrine signature and utility of immunohistochemistry in the diagnosis of apocrine lesions of the breast
    Clare D'Arcy, Cecily M Quinn
    Journal of Clinical Pathology.2019; 72(1): 7.     CrossRef
  • Enhancing Abiraterone Acetate Efficacy in Androgen Receptor–positive Triple-negative Breast Cancer: Chk1 as a Potential Target
    Thomas Grellety, Celine Callens, Elodie Richard, Adrien Briaux, Valérie Vélasco, Marina Pulido, Anthony Gonçalves, Pierre Gestraud, Gaetan MacGrogan, Hervé Bonnefoi, Bruno Cardinaud
    Clinical Cancer Research.2019; 25(2): 856.     CrossRef
  • A clinicopathologic study of invasive apocrine carcinoma of the breast: A single-center experience
    Denira Imamovic, Nurija Bilalovic, Faruk Skenderi, Vanesa Beslagic, Timur Ceric, Berisa Hasanbegovic, Semir Beslija, Semir Vranic
    The Breast Journal.2018; 24(6): 1105.     CrossRef
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    Ning Zhang, Hanwen Zhang, Tong Chen, Qifeng Yang
    Oncotarget.2017; 8(15): 24579.     CrossRef
  • Pure Apocrine Carcinomas Represent a Clinicopathologically Distinct Androgen Receptor–Positive Subset of Triple-Negative Breast Cancers
    Anne M. Mills, Chelsea E. Gottlieb, Scott M. Wendroth, Christiana M. Brenin, Kristen A. Atkins
    American Journal of Surgical Pathology.2016; 40(8): 1109.     CrossRef
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    Ramesh Narayanan, James Dalton
    Cancers.2016; 8(12): 108.     CrossRef
  • Early versus late distant metastasis and adjuvant chemotherapy alone versus both radiotherapy and chemotherapy in molecular apocrine breast cancer
    Xiaozhen Liu, Yang Yang, Xiaolong Feng, Honghong Shen, Jian Liu, Xia Liu, Yun Niu
    Oncotarget.2016; 7(31): 48905.     CrossRef
  • Molecular and diagnostic features of apocrine breast lesions
    Pavel Gromov, Jaime A Espinoza, Irina Gromova
    Expert Review of Molecular Diagnostics.2015; 15(8): 1011.     CrossRef
  • Prevalencia de receptores androgénicos en el cáncer de mama
    Claudia Janeth Rodríguez-Silva, José Luis González-Vela, Ascary Alcides Velázquez-Pacheco
    Gaceta Mexicana de Oncología.2015; 14(3): 135.     CrossRef
Expression of Human Papillomavirus-Related Proteins and Its Clinical Implication in Tonsillar Squamous Cell Carcinoma
Joon Seon Song, Min-Sik Kim, Joon Wook Park, Youn Soo Lee, Chang Suk Kang
Korean J Pathol. 2012;46(2):177-186.   Published online April 25, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.2.177
  • 7,872 View
  • 36 Download
  • 9 Citations
AbstractAbstract PDF
Background

Human papillomavirus (HPV) is known to cause of oropharyngeal squamous cell carcinoma (SqCC). HPV positive SqCCs overexpress p16 and are associated with better survival. Several markers of cell cycles and apoptosis have been reported as a prognostic value. We examined the prognostic value of HPV status, p16, cyclin D1, and Bcl-2 in patients with tonsillar SqCC.

Methods

Tissue microarrays were constructed in 56 cases of tonsillar SqCC for which we performed an immunohistochemistry and an in situ hybridization (ISH) of the HPV.

Results

Of the 56 cases, 31 (55.3%) were positive for p16 and 20 (35.7%) were positive for HPV ISH. The expressions of p16, cyclin D1, and Bcl-2 were not correlated with the clinicopathologic variables including smoking status, differentiation and pT- and pN-stages. The HPV ISH positive group showed a better overall survival than the HPV negative group (p=0.04), and the p16 positive group showed a better disease free survival (DFS) than the negative group (p=0.016). Cox regression analysis showed that only p16 positivity was an independent prognostic factor for DFS (p=0.03; hazard ratio, 10.1).

Conclusions

Our results indicate that both p16 expression and HPV status are useful indicators for risk stratification in patients with tonsillar SqCC.

Citations

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  • Positive Rate of Human Papillomavirus and Its Trend in Head and Neck Cancer in South Korea
    Hyun Woong Jun, Yong Bae Ji, Chang Myeon Song, Jae Kyung Myung, Hae Jin Park, Kyung Tae
    Frontiers in Surgery.2022;[Epub]     CrossRef
  • Negative Prognostic Implication of TERT Promoter Mutations in Human Papillomavirus–Negative Tonsillar Squamous Cell Carcinoma Under the New 8th AJCC Staging System
    Hyunchul Kim, Mi Jung Kwon, Bumjung Park, Hyo Geun Choi, Eun Sook Nam, Seong Jin Cho, Kyueng-Whan Min, Eun Soo Kim, Hee Sung Hwang, Mineui Hong, Taeryool Koo, Hyo Jung Kim
    Indian Journal of Surgical Oncology.2021; 12(S1): 134.     CrossRef
  • In situ hybridization for high risk HPV E6/E7 mRNA in oropharyngeal squamous cell carcinoma
    Krish Suresh, Parth V. Shah, Sydney Coates, Borislav A. Alexiev, Sandeep Samant
    American Journal of Otolaryngology.2021; 42(1): 102782.     CrossRef
  • Prevalence of high-risk human papillomavirus and its genotype distribution in head and neck squamous cell carcinomas
    Yuil Kim, Young-Hoon Joo, Min-Sik Kim, Youn Soo Lee
    Journal of Pathology and Translational Medicine.2020; 54(5): 411.     CrossRef
  • Human Papillomavirus Testing in Head and Neck Carcinomas: Guideline From the College of American Pathologists
    James S. Lewis, Beth Beadle, Justin A. Bishop, Rebecca D. Chernock, Carol Colasacco, Christina Lacchetti, Joel Todd Moncur, James W. Rocco, Mary R. Schwartz, Raja R. Seethala, Nicole E. Thomas, William H. Westra, William C. Faquin
    Archives of Pathology & Laboratory Medicine.2018; 142(5): 559.     CrossRef
  • Detection of HPV infection in head and neck cancers: Promise and pitfalls in the last ten years: A meta-analysis
    Carolin G�tz, Clara Bischof, Klaus-Dietrich Wolff, Andreas Kolk
    Molecular and Clinical Oncology.2018;[Epub]     CrossRef
  • Frequent hepatocyte growth factor overexpression and low frequency of c-Met gene amplification in human papillomavirus–negative tonsillar squamous cell carcinoma and their prognostic significances
    Mi Jung Kwon, Dong Hoon Kim, Hye-Rim Park, Hyung Sik Shin, Ji Hyun Kwon, Dong Jin Lee, Jin Hwan Kim, Seong Jin Cho, Eun Sook Nam
    Human Pathology.2014; 45(7): 1327.     CrossRef
  • Human papillomavirus-stratified analysis of the prognostic role of miR-21 in oral cavity and oropharyngeal squamous cell carcinoma
    Yoon Ho Ko, Hye Sung Won, Der Sheng Sun, Ho Jung An, Eun Kyoung Jeon, Min Sik Kim, Han Hong Lee, Jin Hyoung Kang, Chan Kwon Jung
    Pathology International.2014; 64(10): 499.     CrossRef
  • Human Papillomavirus Prevalence and Cell Cycle Related Protein Expression in Tonsillar Squamous Cell Carcinomas of Korean Patients with Clinicopathologic Analysis
    Miji Lee, Sung Bae Kim, Sang-wook Lee, Jong-Lyel Roh, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim, Kyung-Ja Cho
    Korean Journal of Pathology.2013; 47(2): 148.     CrossRef
Case Reports
Primary Monophasic Synovial Sarcoma Arising in the Mesentery: Case Report of an Extremely Rare Mesenteric Sarcoma Confirmed by Molecular Detection of a SYT-SSX2 Fusion Transcript
Han Suk Ryu, Ilyeong Heo, Jae Soo Koh, Sung-Ho Jin, Hye Jin Kang, Soo Youn Cho
Korean J Pathol. 2012;46(2):187-191.   Published online April 25, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.2.187
  • 5,396 View
  • 29 Download
  • 2 Citations
AbstractAbstract PDF

Synovial sarcoma arises in the para-articular tissues, and it can also occur in various unexpected sites. We report a rare case of primary monophasic synovial sarcoma (MSS) arising in the mesentery. A 59-year-old man presented with a palpable abdominal mass. On microscopic examination, the entire tumor comprised a dense proliferation of the spindle cells without epithelial components. The tumor cells were positive for transducin-like enhancer of split 1, bcl-2, epithelial membrane antigen and CD99 but negative for CD34, CD117, alpha-smooth muscle actin, cytokeratin, and calretinin on immunohistochemistry. The reverse transcriptase-polymerase chain reaction revealed a single 151-bp fragment representing the SYT-SSX2 fusion transcript. Because mesenteric MSS is extremely rare and many cases display histologic findings that overlap with those of more frequently involved tumors such as hemangiopericytoma and gastrointestinal stromal tumor, there is a chance of making an incorrect diagnosis that can result in an inappropriate treatment.

Citations

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  • Giant solitary fibrous tumor of the pelvis: A case report and review of literature
    Gerardo Palmieri, Carmine Grassi, Luigi Conti, Filippo Banchini, Maria Diletta Daccò, Gaetano M. Cattaneo, Patrizio Capelli
    International Journal of Surgery Case Reports.2020; 77: S52.     CrossRef
  • Tumeur neuroectodermique gastro-intestinale (GNET) : à propos d’un cas de tumeur du grêle avec métastases hépatiques
    Thibault Kervarrec, Claire Lecointre, Rémy Kerdraon, Guido Bens, Arnaud Piquard, Patrick Michenet
    Annales de Pathologie.2015; 35(6): 506.     CrossRef
Ectomesenchymal Chondromyxoid Tumor in the Anterior Tongue: Case Report of a Unique Tumor
Min Gyoung Pak, Kyung Bin Kim, Nari Shin, Woo Kyung Kim, Dong Hoon Shin, Kyung Un Choi, Mee Young Sol
Korean J Pathol. 2012;46(2):192-196.   Published online April 25, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.2.192
  • 6,230 View
  • 51 Download
  • 5 Citations
AbstractAbstract PDF

Ectomesenchymal chondromyxoid tumor (ECMT) is a rare tumor, exclusively arising in the anterior tongue. Thirty-eight cases have been reported in the English literature. It usually presents as a sessile protrusion and shows round to spindle cells embedded in myxoid to chondroid stroma. Tumor cells are almost always positive for polyclonal glial fibrillary acidic protein (GFAP). We report our experience in the recent treatment of a case of ECMT, the third case in 3 years. The mass in the anterior tongue revealed characteristic morphologic features of ECMT and the expression of polyclonal GFAP. Although ECMT should be differentiated from other mesenchymal tumors including myoepithelioma, its clinical, morphological, and immunohistochemical features enable its diagnosis, especially when pathologists are aware of it.

Citations

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  • Chondroid choristoma of the tongue: A rare case report
    Sumaiya Nezam, Roquaiya Nishat, ShababAhmed Khan, JeevendraNath Shukla
    National Journal of Maxillofacial Surgery.2022;[Epub]     CrossRef
  • Ectomesenchymal chondromyxoid tumor: a comprehensive updated review of the literature and case report
    Astrid Truschnegg, Stephan Acham, Lumnije Kqiku, Norbert Jakse, Alfred Beham
    International Journal of Oral Science.2018;[Epub]     CrossRef
  • Clinical features of ectomesenchymal chondromyxoid tumors: A systematic review of the literature
    Masanari G. Kato, Evren Erkul, Kendall S. Brewer, Emily E. Harruff, Shaun A. Nguyen, Terry A. Day
    Oral Oncology.2017; 67: 192.     CrossRef
  • Cyclin D1 Expression in Ectomesenchymal Chondromyxoid Tumor of the Anterior Tongue
    Jan Laco, Radovan Mottl, Walter Höbling, Stephan Ihrler, Petr Grossmann, Alena Skalova, Ales Ryska
    International Journal of Surgical Pathology.2016; 24(7): 586.     CrossRef
  • Nodular lesion in the buccal mucosa
    Bruna Jalfim Maraschin, Ana Carolina Amorim Pellicioli, Lélia Batista de Souza, Pantelis Varvaki Rados, Marco Antonio Trevizani Martins, Manoela Domingues Martins
    The Journal of the American Dental Association.2015; 146(3): 196.     CrossRef
Parathyromatosis: Critical Diagnosis Regarding Surgery and Pathologic Evaluation
Ayşegül Aksoy-Altinboga, Ayşegül Akder Sari, Türkan Rezanko, Mehmet Haciyanli, Aylin Orgen Calli
Korean J Pathol. 2012;46(2):197-200.   Published online April 25, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.2.197
  • 6,402 View
  • 40 Download
  • 9 Citations
AbstractAbstract PDF

Parathyromatosis, in which several nodules of hyperfunctioning parathyroid tissue form in the neck and mediastinum, is a rare cause of recurrent hyperparathyroidism. However, there are some theories regarding the origin of parathyromatosis, and seeding after rupture of the parathyroid gland capsule during surgical removal of a parathyroid lesions is the most regarded one. Herein, we report a 41-year-old man who presented with multiple parathyroid nodules in and around the left thyroid lobe 5 years after parathyroid surgery for secondary hyperparathyroidism that was finally diagnosed as parathyromatosis. We discuss the differential diagnosis of parathyromatosis from other parathyroid tumors, particularly from parathyroid carcinoma, which is important in the management of a suspected lesion.

Citations

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  • Histological alterations following fine‐needle aspiration for parathyroid adenoma: Incidence and diagnostic problems
    Mitsuyoshi Hirokawa, Ayana Suzuki, Miyoko Higuchi, Toshitetsu Hayashi, Seiji Kuma, Akihiro Miya, Akira Miyauchi
    Pathology International.2021; 71(6): 400.     CrossRef
  • Parathyromatosis as a cause of recurrence primary hyperparathyroidism: A case report
    Elena A. Ilyicheva, Gleb A. Bersenev
    International Journal of Surgery Case Reports.2021; 80: 105689.     CrossRef
  • Seguridad y rendimiento diagnóstico de la medición de PTH en el lavado del aspirado de lesiones sospechosas de adenomas de paratiroides
    Florentino Carral, Ana Isabel Jiménez, Mariana Tomé, Javier Alvarez, Ana Díez, Concepción García, Vicente Vega, Carmen Ayala
    Endocrinología, Diabetes y Nutrición.2021; 68(7): 481.     CrossRef
  • Safety and diagnostic performance of parathyroid hormone assay in fine-needle aspirate in suspicious parathyroid adenomas
    Florentino Carral, Ana Isabel Jiménez, Mariana Tomé, Javier Alvarez, Ana Díez, Concepción García, Vicente Vega, Carmen Ayala
    Endocrinología, Diabetes y Nutrición (English ed.).2021; 68(7): 481.     CrossRef
  • Persistent secondary hyperparathyroidism caused by parathyromatosis and supernumerary parathyroid glands in a patient on haemodialysis
    Jun Yang, Jun Zhang, Ning-hu Liu, Hao Liu, Meng-jie Dong
    BMC Nephrology.2020;[Epub]     CrossRef
  • Parathyromatosis: A Rare Case of Recurrent Hyperparathyroidism Localized by Four-Dimensional Computed Tomography
    Abraham E. Wei, Matthew R. Garrett, Ankur Gupta
    AACE Clinical Case Reports.2019; 5(6): e384.     CrossRef
  • Parathyromatosis: a very rare cause of recurrent primary hyperparathyroidism – case report and review of the literature
    M Haciyanli, S Karaisli, S Gucek Haciyanli, A Atasever, D Arikan Etit, EO Gur, T Acar
    The Annals of The Royal College of Surgeons of England.2019; 101(8): e178.     CrossRef
  • Parathyromatose : une cause rare d’hyperparathyroïdie récidivante
    I. Achour, S. Charfi, M.A. Chaabouni, A. Chakroun, F. Guermazi, B. Hammami, A. Ghorbel
    La Revue de Médecine Interne.2017; 38(1): 61.     CrossRef
  • Recurrent primary hyperparathyroidism due to Type 1 parathyromatosis
    Monica Jain, David L. Krasne, Frederick R. Singer, Armando E. Giuliano
    Endocrine.2017; 55(2): 643.     CrossRef
Melanotic Oncocytic Metaplasia of the Nasopharynx: A Report of Three Cases and Review of the Literature
Joo Young Na, Yeong Hui Kim, Yoo Duk Choi, Ji Shin Lee
Korean J Pathol. 2012;46(2):201-204.   Published online April 25, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.2.201
  • 7,145 View
  • 42 Download
  • 9 Citations
AbstractAbstract PDF

Melanotic oncocytic metaplasia of the nasopharynx is a rare condition which is characterized by the presence of usually a small, brown to black colored pigmented lesion around the Eustachian tube opening. Although it is a benign lesion, it may be clinically misdiagnosed as malignant melanoma. Microscopically, melanotic oncocytic metaplasia is a combination of oncocytic metaplasia of the epithelium of the gland and melanin pigmentation in its cytoplasm. In our present study, we report three cases of melanotic oncocytic metaplasia of the nasopharynx. All the three cases occurred in men and were presented as multiple black pigmented lesions around the torus tubarius. Microscopically, mucous glands with diffuse oncocytic metaplasia and numerous black pigments were observed. No cellular atypia was observed. Immunohistochemically, the scattering of S-100 protein-positive, and human melanoma black 45-negative dendritic melanocytes was evident. This is the first report of cases of melanotic oncocytic metaplasia of the nasopharynx in Korea.

Citations

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  • Lesions that mimic malignant tumors in nasopharyngeal biopsies: case series of 10 years
    Mine Ozsen, Ozlem Saraydaroglu, Selin Yirmibes, H. Hakan Coskun
    Tumori Journal.2022; 108(2): 119.     CrossRef
  • Melanotic Oncocytic Metaplasia of the Nasopharynx Seen as a Rare Form of Cystic Mass: A Case Report and Review of the Literature
    Keun-Ik Yi, Yong-Wan Kim
    Journal of Clinical Otolaryngology Head and Neck Surgery.2022; 33(1): 23.     CrossRef
  • Melanotic Oncocytic Metaplasia of the Nasopharynx: A Case Report With Review of Literature
    Hsing-Yu Chen, Mpendulo Felix Gule, I-Wei Chang
    Ear, Nose & Throat Journal.2021; 100(5_suppl): 771S.     CrossRef
  • Malignant Mucosal Melanoma of the Eustachian Tube With Extension Into the Ipsilateral External Ear Canal: A Case Report and Review of the Literature
    Lifeng Li, Nyall R. London, Xiaohong Chen
    Ear, Nose & Throat Journal.2021; 100(5_suppl): 730S.     CrossRef
  • Melanotic oncocytic metaplasia of the nasopharynx: A case report discussing the pathogenesis of a lesion
    Shina Sakaguchi, Hiromasa Takakura, Shin-ichi Hayashi, Akira Noguchi, Hirohiko Tachino, Hideo Shojaku, Johji Imura
    Otolaryngology Case Reports.2021; 20: 100276.     CrossRef
  • Oncocytic Cysts of the Nasopharynx: A Case Report
    Joshua C. Hwang, Raj D. Dedhia, Joan E. Bernard, Toby O. Steele
    Allergy & Rhinology.2020; 11: 215265672095659.     CrossRef
  • Melanotic Oncocytic Metaplasia of the Nasopharynx in the Patient with Suspicious Hemoptysis: Case Report
    Taek Yoon Cheong, Han Seong Kim, Ick Soo Choi
    Journal of Rhinology.2020; 27(2): 140.     CrossRef
  • Clinicopathological features of melanotic and non-melanotic oncocytic lesions of the nasopharynx
    Joshua J.X. Li, Joanna K.M. Ng, Amy B.W. Chan
    Pathology.2019; 51(6): 600.     CrossRef
  • Melanotic oncocytic metaplasia of the nasopharynx
    Keiichiro Uehara, Yu Usami, Yukihiro Imai, Michio Shimizu
    Pathology International.2015; 65(3): 144.     CrossRef
Invasive Cribriform Carcinoma Arising in Malignant Phyllodes Tumor of Breast: A Case Report
Yoomi Choi, Kyoung Yul Lee, Min Hye Jang, Hyesil Seol, Sung-Won Kim, So Yeon Park
Korean J Pathol. 2012;46(2):205-209.   Published online April 25, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.2.205
  • 6,391 View
  • 43 Download
  • 2 Citations
AbstractAbstract PDF

Phyllodes tumor is an uncommon fibroepithelial neoplasm of the breast. And it is characterized by expanded stroma with increased cellularity and elongated epithelium-lined clefts. Mammary carcinomas within phyllodes tumors have been rarely reported. To date, however, no reports have described the invasive cribriform carcinoma arising in malignant phyllodes tumor. Here, we report a 62-year-old woman who presented with a large breast mass. Microscopically, the mass was a typical malignant phyllodes tumor showing well developed leaf-like architecture and stromal overgrowth with high cellularity and nuclear pleomorphism. In a portion of the tumor, however, the epithelial component showed a cribriform pattern of proliferation in the absence of myoepithelial cells, suggestive of the invasive cribriform carcinoma. To our knowledge, this is rare and it is difficult to make a differential diagnosis of it. Here, we report our case with a review of literatures.

Citations

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  • Unexpectedly High Coexistence Rate of In Situ/Invasive Carcinoma In Phyllodes Tumors. 10-Year Retrospective and Review Study
    Öykü Dila Gemci, Serdar Altınay, Rümeysa İlbar Tartar, Sina Ferahman
    European Journal of Breast Health.2022; 18(4): 343.     CrossRef
  • Invasive ductal carcinoma within borderline phyllodes tumor with lymph node metastases: A case report and review of the literature
    DI WU, HAIPENG ZHANG, LIANG GUO, XU YAN, ZHIMIN FAN
    Oncology Letters.2016; 11(4): 2502.     CrossRef

JPTM : Journal of Pathology and Translational Medicine