Journal of Pathology and Translational Medicine

Volume 46(2); April 2012

Original Articles

Clinicopathologic Features of IgA-Dominant Postinfectious Glomerulonephritis: Tai Yeon Koo, Gheun-Ho Kim, Moon Hyang Park; Korean J Pathol. 2012;46(2):105-114. Published online April 25, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.2.105

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Background

IgA-dominant acute postinfectious glomerulonephritis (APIGN) is a recently recognized morphologic variant of APIGN, but its clinicopathologic features were not clearly characterized. We will present demographic, clinical and renal biopsy findings from seven patients with IgA-dominant APIGN with a literature review.

Methods

All renal biopsy specimens (n=1,119) processed by the Department of Pathology in Hanyang University Hospital from 2005 to 2009 were reviewed. Seven patients with IgA-dominant APIGN were identified, and their clinical data analyzed.

Results

All patients had renal failure, hematuria and proteinuria. One was diabetic, and none of the patients had previous renal diseases. Three had clinical infections at the time of presentation: 2 with methicillin-resistant Staphylococcus aureus and one with rickettsial infection. Light microscopically diffuse endocapillary proliferative and exudative glomerulonephritis was found in all cases. Immunofluorescence microscopy showed granular IgA deposits along peripheral capillary walls and in mesangium. Ultrastructurally, subepithelial 'humps' with mesangial deposits were noted. End-stage renal disease developed in two patients, chronic renal failure was stationary in two, and azotemia improved in three.

Conclusions

Various infections including rickettsiosis preceded IgA-dominant APIGN in both diabetics and nondiabetics. Because the prognosis of IgA-dominant APIGN is poor, early diagnosis based on renal biopsy is required.

Citations

Citations to this article as recorded by

Staphylococcus aureus Infection-Related Glomerulonephritis with Dominant IgA Deposition
Mamiko Takayasu, Kouichi Hirayama, Homare Shimohata, Masaki Kobayashi, Akio Koyama
International Journal of Molecular Sciences.2022; 23(13): 7482. CrossRef
A rare case of Immunoglobulin A dominant post-infectious glomerulonephritis (IgA PIGN) in a young patient
A. Saghar, G. Klaus, B. Trutnau, M. Kömhoff, H. J. Gröne, S. Weber
BMC Nephrology.2022;[Epub] CrossRef
IgA-Dominant Infection-Associated Glomerulonephritis Following SARS-CoV-2 Infection
Aurora Pérez, Isidro Torregrosa, Luis D’Marco, Isabel Juan, Liria Terradez, Miguel Ángel Solís, Francesc Moncho, Carmen Carda-Batalla, María J. Forner, Jose Luis Gorriz
Viruses.2021; 13(4): 587. CrossRef
Relationship between blood neutrophil‐lymphocyte ratio and renal tubular atrophy/interstitial fibrosis in IgA nephropathy patients
Lingxiong Chai, Kedan Cai, Kaiyue Wang, Qun Luo
Journal of Clinical Laboratory Analysis.2021;[Epub] CrossRef
The Continuing Need for Electron Microscopy in Examination of Medical Renal Biopsies: Examples in Practice
Michifumi Yamashita, Mercury Y. Lin, Jean Hou, Kevin Y.M. Ren, Mark Haas
Glomerular Diseases.2021; 1(3): 145. CrossRef
Clinicopathologic features of infection-related glomerulonephritis with IgA deposits: a French Nationwide study
Elodie Miquelestorena-Standley, Charlotte Jaulerry, Marie-Christine Machet, Nolwenn Rabot, Christelle Barbet, Aurélie Hummel, Alexandre Karras, Cyril Garrouste, Thomas Crepin, Didier Ducloux, Maud Cousin, Catherine Albert, Joseph Rivalan, Emilie Cornec-Le
Diagnostic Pathology.2020;[Epub] CrossRef
IgA nephropathy and infections
Cristiana Rollino, Gisella Vischini, Rosanna Coppo
Journal of Nephrology.2016; 29(4): 463. CrossRef
<i>Staphylococcus</i>-associated Glomerulonephritis
Dong Yeol Shin, Sung Han Kim, Ji Wan Lee, Ki Ju Chang, Seung Ha Hwang, Yong Mee Cho, Soon Bae Kim
The Korean Journal of Medicine.2016; 90(2): 148. CrossRef
Use of steroid therapy in immunoglobulin A-dominant poststaphylococcal glomerulonephritis
Mahesh Eswarappa, Vijay Varma, K.C. Gurudev
Hong Kong Journal of Nephrology.2015; 17(2): 46. CrossRef
Clinicopathologic Features of IgA-Dominant Infection-Associated Glomerulonephritis: A Pooled Analysis of 78 Cases
Ru Bu, Qian Li, Zhi-yu Duan, Jie Wu, Pu Chen, Xiang-mei Chen, Guang-yan Cai
American Journal of Nephrology.2015; 41(2): 98. CrossRef
Garland-pattern postinfectious glomerulonephritis with IgA-dominant deposition
Makoto Kanno, Kenichi Tanaka, Hiroshi Kimura, Kimio Watanabe, Yoshimitsu Hayashi, Koichi Asahi, Masaaki Nakayama, Kensuke Joh, Tsuyoshi Watanabe
CEN Case Reports.2014; 3(1): 56. CrossRef

Diagnostic Value of MDM2 and DDIT3 Fluorescence In Situ Hybridization in Liposarcoma Classification: A Single-Institution Experience: Junhun Cho, Seung Eun Lee, Yoon-La Choi; Korean J Pathol. 2012;46(2):115-122. Published online April 25, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.2.115

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Abstract PDF

Background

The amplification of murine double minutes (MDM2) is the primary feature of well-differentiated liposarcomas (WDLPS) and dedifferentiated liposarcomas (DDLPS), while DDIT3 rearrangement is the main one of myxoid liposarcomas (MLPS). Our aim was to evaluate the added value of MDM2 amplification and DDIT3 rearrangement in making a diagnosis and classifying lipogenic tumors.

Methods

Eighty-two cases of liposarcoma and 60 lipomas diagnosed between 1995 and 2010 were analysed for MDM2 amplification and DDIT3 rearrangement using a fluorescence in situ hybridization (FISH). The subtypes of liposarcoma were reclassified according to the molecular results, whose results were reviewed with an analysis of the relevant histologic and immunohistochemical findings.

Results

One case of lipoma (1.67%) was reclassified as a WDLPS. Of the liposarcomas, 13.4% (16/82) were reclassified after the molecular testing. Five cases of MLPS were reclassified as four cases of DDLPS and one case of myxoid lipoma. Two cases of WDLPS were reclassified as one case of spindle cell lipoma and another case of myxofibrosarcoma. Four cases of DDLPS were reclassified as two cases of leiomyosarcoma, one case of angiomyolipoma and another case of fibroinflammatory lesion. Of the six cases of pleomorphic liposarcoma, five were reclassified as DDLPS.

Conclusions

In our series, a critical revision of diagnosis was found at a rate of 3.5% (5/142) after a review of the lipomatous lesions. The uses of molecular testing by MDM2 and DDIT3 FISH were valuable to make an accurate subtyping of liposarcomas as well as to differentiate WDLPS from benign lipomatous tumor.

Citations

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Myxoid liposarcoma with nuclear pleomorphism: a clinicopathological and molecular study
Naoki Kojima, Takashi Kubo, Taisuke Mori, Kaishi Satomi, Yuko Matsushita, Shintaro Iwata, Yasushi Yatabe, Koichi Ichimura, Akira Kawai, Hitoshi Ichikawa, Akihiko Yoshida
Virchows Archiv.2024; 484(1): 71. CrossRef
FISH Diagnostic Assessment of MDM2 Amplification in Liposarcoma: Potential Pitfalls and Troubleshooting Recommendations
Alessandro Gambella, Luca Bertero, Milena Rondón-Lagos, Ludovica Verdun Di Cantogno, Nelson Rangel, Chiara Pitino, Alessia Andrea Ricci, Luca Mangherini, Isabella Castellano, Paola Cassoni
International Journal of Molecular Sciences.2023; 24(2): 1342. CrossRef
Expression of CTAG1B clone EPR13780 versus DDIT3 gene rearrangement distinguishes myxoid liposarcoma from its mimics with detection of novel DDIT3 gene copy number variations
Marwa M. Abdelaziz, Hanan Y. Tayel, Amany Abdel-Bary, Omnia M. Badawy
Journal of Histotechnology.2022; 45(2): 56. CrossRef
Musculoskeletal Tumors
Amit Singla, David S. Geller
Pediatric Clinics of North America.2020; 67(1): 227. CrossRef
Vulvar Myxoid Liposarcoma, an Extremely Rare Diagnosis: A Case Report and Review of Literature
Ligia Redroban, Nelson Montalvo
International Journal of Gynecological Pathology.2019; 38(1): 17. CrossRef
Molecular updates in adipocytic neoplasms✰
Elizabeth G. Demicco
Seminars in Diagnostic Pathology.2019; 36(2): 85. CrossRef
Application of MDM2 Fluorescence In Situ Hybridization and Immunohistochemistry in Distinguishing Dedifferentiated Liposarcoma From Other High-grade Sarcomas
Min Jeong Song, Kyung-Ja Cho, Jong-Seok Lee, Joon Seon Song
Applied Immunohistochemistry & Molecular Morphology.2017; 25(10): 712. CrossRef
FluorescenceIn SituHybridization forMDM2Amplification as a Routine Ancillary Diagnostic Tool for Suspected Well-Differentiated and Dedifferentiated Liposarcomas: Experience at a Tertiary Center
Khin Thway, Jayson Wang, John Swansbury, Toon Min, Cyril Fisher
Sarcoma.2015; 2015: 1. CrossRef

Difference of Genome-Wide Copy Number Alterations between High-Grade Squamous Intraepithelial Lesions and Squamous Cell Carcinomas of the Uterine Cervix: Bum Hee Lee, Sangyoung Roh, Yu Im Kim, Ahwon Lee, Su Young Kim; Korean J Pathol. 2012;46(2):123-130. Published online April 25, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.2.123

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Abstract PDF

Background

About 10% of high-grade squamous intraepithelial lesions (HSILs) progress to invasive carcinomas within 2-10 years. By delineating the events that occur in the early stage of the invasion, the pathogenesis of cervical cancer could be better understood. This will also propose the possible methods for inhibiting the tumor invasion and improving the survival of patients.

Methods

We compared the genomic profiles between the HSIL and the invasive squamous cell carcinoma (SCC) using an array comparative genomic hybridization. Using recurrently altered genes, we performed a principal component analysis to see variation of samples in both groups. To find possibly affected pathways by altered genes, we analyzed genomic profiles with the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway database and GOEAST software.

Results

We found 11q12.3 and 2p24.1 regions have recurrent copy number gains in both groups. 16p12-13 and 20q11-13 regions showed an increased copy number only in cases of HSIL. 1q25.3 and 3q23-29 regions showed copy number gains only in cases of SCC. Altered genes in the SCC group were related to the mitogen-activated protein kinase signaling pathway and the RNA transport. Altered genes in the HSIL group were related to the ubiquitin mediated proteolysis and cell adhesion molecules.

Conclusions

Our results showed not only that gains in 11q12.3 and 2p24.1 were early events occurring in the premalignant lesions and then maintained in cases of SCC but also that gains in 1q25.3 and 3q23-29 were late events occurring after invasion in those of SCC.

Citations

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Cytokeratin and protein expression patterns in squamous cell carcinoma of the oral cavity provide evidence for two distinct pathogenetic pathways
GESCHE FROHWITTER, HORST BUERGER, PAUL J. VAN DIEST, EBERHARD KORSCHING, JOHANNES KLEINHEINZ, THOMAS FILLIES
Oncology Letters.2016; 12(1): 107. CrossRef
'Drawing' a Molecular Portrait of CIN and Cervical Cancer: a Review of Genome-Wide Molecular Profiling Data
Olga V Kurmyshkina, Pavel I Kovchur, Tatyana O Volkova
Asian Pacific Journal of Cancer Prevention.2015; 16(11): 4477. CrossRef

Markers for Screening Lynch Syndrome Are Reliable and Useful for Identifying the Specimen Mislabeling: Sun-ju Byeon, Jiwoon Choi, Kyung Han Nam, Bo-Gun Jang, Hee Eun Lee, Min A Kim, Woo Ho Kim; Korean J Pathol. 2012;46(2):131-136. Published online April 25, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.2.131

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Abstract PDF

Background

During specimen processing in surgical pathology laboratories, specimen-related adverse events (SRAEs), such as mislabeling and specimen mixed-up might occur. In these situations, molecular techniques using short tandem repeat (STR) loci are required to identify the personal identity. Microsatellite instability (MSI) test is widely used for screening the hereditary non-polyposis colon cancer (Lynch syndrome) in surgical pathologies using polymorphic STR markers. We tried to evaluate the applicability of the MSI test for SRAEs.

Methods

We obtained 253 MSI test results to analyze the allele frequencies. After calibrating the estimated nucleotide lengths, we calculated the allele frequencies, a random match probability, and a likelihood ratio (LR) of three dinucleotide STR markers (D5S349, D17S250, and D2S123).

Results

The distribution of LR was 136.38 to 5,606,213.10. There was no case of LR<100. In addition, there were 153 cases (60.5%) of LR ranging from 100 to 10,000 and 100 cases (39.5%) of LR>10,000. Furthermore, the combined probability of identity was 9.23×10^-4 and the combined power of exclusion was 0.99908.

Conclusions

Using the three STR markers that are recommended for MSI test, all the cases were positively identified in 1% range and about one-third cases showed high LR (>10,000). These results showed that MSI tests are useful to screen the personal identity in case of SRAE in pathology laboratories.

Citations

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Sensitivity and polymorphism of Bethesda panel markers in Chinese population
Yanying Zheng, Jie Chen, Xiang Zhang, Ling Xie, Yifen Zhang, Yi Sun
Bulletin du Cancer.2020; 107(11): 1091. CrossRef

Significance of Electron Dense Deposits in Patients with Minimal Change Nephrotic Syndrome: Sae Yoon Kim, Sang Su Lee, Myoung Uk Kim, Jae Min Lee, Seok Jeong Kang, Yong Jin Kim, Yong Hoon Park; Korean J Pathol. 2012;46(2):137-141. Published online April 25, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.2.137

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Abstract PDF: Background
Minimal change nephritic syndrome (MCNS) is characterized by a lack of obvious abnormalities on light microscopy, but its electron microscopic findings include the negative immunofluorescence findings and the diffuse effacement of the epithelial cell foot processes. Rarely the presence of electron dense deposits (EDDs) has been reported, but its clinical significance remains obscure.
Methods
Eleven patients with MCNS who had the EDD deposited were enrolled in the current study. We compared the clinical characteristics, laboratory results and response to steroid treatment between the two group: the EDD group (n=11; the male-to-female ratio, 8:3) and the non-EDD group (n=13, 8:5).
Results
There were no significant differences in most of the laboratory results or response to steroid treatment between the two groups. The frequency of relapses per year was significantly higher in the EDD group (1.1±0.7 times vs. 0.5±0.6 times; p=0.023). These EDDs were found in the mesangium or paramesangium. With no respect to the characteristics of EDDs, our results showed that they did not cause poor treatment outcomes except for the annual frequency of relapse.
Conclusions
Further large-scale studies are warrented to determine the immunologic and prognostic significance of EDDs in patients with MCNS.

Expression of HAT1 and HDAC1, 2, 3 in Diffuse Large B-Cell Lymphomas, Peripheral T-Cell Lymphomas, and NK/T-Cell Lymphomas: Soo Kee Min, Young Ho Koh, Yunwoong Park, Hyo Jung Kim, Jinwon Seo, Hye-Rim Park, Seong Jin Cho, In Sun Kim; Korean J Pathol. 2012;46(2):142-150. Published online April 25, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.2.142

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Abstract PDF

Background

It has generally been proven that histone acetylation and deacetylation are involved in the malignant transformation. To date, however, this has rarely been studied in cases of malignant lymphoma.

Methods

We studied nine cases of reactive lymphoid hyperplasia, 78 cases of diffuse large B-cell lymphoma (DLBCL), 13 cases of peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), and 13 cases of extranodal NK/T-cell lymphoma, nasal type (NKTCL). Thus, we attempted to elucidate the associations of the degree of the expression of histone acetyltransferase 1 (HAT1), histone deacetylase (HDAC) 1, HDAC2, and HDAC3 with the clinical behaviors of above malignant lymphomas using the immunohistochemistry and a western blot analysis.

Results

The degree of the expression of HAT1 was higher in cases of DLBCL, PTCL-NOS or NKTCL as compared with reactive lymphoid hyperplasia (p<0.05). The degree of the expression of HAT1 was correlated with that of HDAC1 in cases of DLBCL or NKTCL (p<0.05). The degree of the expression of HAT1 and HDAC1 was correlated with a poor survival in cases of DLBCL or PTCL-NOS (p>0.05).

Conclusions

HAT1, HDAC1, and HDAC2 play a critical role in the development of malignant lymphomas. Both HAT1 and HDAC1 might be indicators for a poor prognosis in cases of DLBCL as cooperating factors.

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Evaluation of Bronchiolar and Alveolar Cell Injuries Induced by Short- and Long-term Exposure to Sidestream Smoke: Kun-Young Kwon, Hye-Ra Jung, Ilseon Hwang, Won-Il Choi; Korean J Pathol. 2012;46(2):151-161. Published online April 25, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.2.151

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Abstract PDF

Background

We investigated effects of short- and long-term exposure to sidestream smoke on the bronchiolar and alveolar cells in Sprague-Dawley rats.

Methods

Rats were divided into five experimental groups: groups 1, 2, and 3 (1-month exposure to 3, 5, and 7 cigarettes a day, respectively), groups 4 and 5 (3- and 6 month exposure to five cigarettes a day, respectively). We examined the morphologic changes, the expressions of tumor necrosis factor α (TNF-α), tumor growth factor β1 (TGF-β1), interlekin (IL)-1α, IL-1β, Ki-67, and cytokeratin 14 and in situ apoptosis in the bronchiolar and alveolar cells on light microscopy (LM) and electron microscopic (EM) terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining.

Results

LM showed the respiratory bronchiolar dilatation and alveolar wall collapse. In groups 3, 4, and 5, EM showed loss of the cilia and Clara cells with irregular size, more prominent alveolar wall collapse and dilation of alveolar duct than those of groups 1 and 2. Bronchiolar and alveolar cells showed increased expressions of TNF-α and TGF-β in groups 4 and 5. LM and EM TUNEL stains showed increased apoptosis in groups 3, 4, and 5.

Conclusions

Sidestream smoke causes a bronchiolar and alveolar cell injury and the severity correlates strongly the volume and duration of exposure to sidestream smoke.

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Cigarette smoke extract alters the cell cycle via the phospholipid transfer protein/transforming growth factor-β1/CyclinD1/CDK4 pathway
Xue-Min Chai, You-Lun Li, Hong Chen, Shu-Liang Guo, Li-Li Shui, Ya-Juan Chen
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American Journal of Respiratory and Critical Care Medicine.2014; 189(9): 1142. CrossRef

Identifying Polymorphisms in IL-31 and Their Association with Susceptibility to Asthma: Ji-In Yu, Weon-Cheol Han, Ki-Jung Yun, Hyung-Bae Moon, Gyung-Jae Oh, Soo-Cheon Chae; Korean J Pathol. 2012;46(2):162-168. Published online April 25, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.2.162

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Abstract PDF

Background

Interleukin 31 (IL-31) is a T helper type 2 effector cytokine that plays an important role in the pathogenesis of atopic and allergic diseases. IL-31 may be involved in promoting allergic inflammation and in inducing airway epithelial responses such as allergic asthma.

Methods

Single-base extension analysis was used to detect the genotypes of IL-31 single nucleotide polymorphisms (SNPs), and we compared the genotype and allele frequencies of the IL-31 SNPs between patients with asthma and healthy controls.

Results

There were no significant differences in the genotype and allele frequencies of the IL-31 SNPs between patients with asthma and healthy controls. Furthermore we compared the genotype and allele frequencies of IL-31 SNPs between patients with atopic asthma, those with non-atopic asthma and healthy controls. This showed that the SNPs were not associated with the susceptibility to atopic asthma. There were no significant differences in the haplotype frequencies of IL-31 SNPs between patients with asthma and healthy controls. In patients with asthma, the IL-31 SNPs were significantly correlated with total serum levels of IgE (p=0.035).

Conclusions

Our results indicate that, the IL-31 SNPs may be associated with IgE production in patients with asthma.

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Dingyu Liu, James G. Wagner, Jack R. Harkema, Miriam E. Gerlofs-Nijland, Elena Pinelli, Gert Folkerts, Rob J. Vandebriel, Flemming R. Cassee
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Yongfeng Yang, Li Li, Fei Chen, Li Zhang, Hong Bu
Genetic Testing and Molecular Biomarkers.2018; 22(5): 314. CrossRef
Associations betweenInterleukin-31Gene Polymorphisms and Dilated Cardiomyopathy in a Chinese Population
Huizi Song, Ying Peng, Bin Zhou, Nan Chen, Xiaochuan Xie, Qingyu Dou, Yue Zhong, Li Rao
Disease Markers.2017; 2017: 1. CrossRef
The association of interleukin-31 polymorphisms with interleukin-31 serum levels and risk of systemic lupus erythematosus
Hua-Tuo Huang, Jian-Ming Chen, Jing Guo, Yan Lan, Ye-Sheng Wei
Rheumatology International.2016; 36(6): 799. CrossRef
Stem Cell Factor and Interleukin-31 Expression: Association with IgE among Egyptian Patients with Atopic and Nonatopic Bronchial Asthma
M. Moaaz, S. Abo El-Nazar, M. Abd El-Rahman, E. Soliman
Immunological Investigations.2016; 45(2): 87. CrossRef
Interleukin-31 expression and relation to disease severity in human asthma
Tianwen Lai, Dong Wu, Wen Li, Min Chen, Zhennan Yi, Dan Huang, Zhiliang Jing, Yingying Lü, Quanchao Lv, Dongming Li, Bin Wu
Scientific Reports.2016;[Epub] CrossRef
Elevated TGF-β1/IL-31 Pathway Is Associated with the Disease Severity of Hepatitis B Virus–Related Liver Cirrhosis
Desong Ming, Xueping Yu, Ruyi Guo, Yong Deng, Julan Li, Chengzu Lin, Milong Su, Zhenzhong Lin, Zhijun Su
Viral Immunology.2015; 28(4): 209. CrossRef
Interleukin-31 promotes helper T cell type-2 inflammation in children with allergic rhinitis
Wenlong Liu, Renzhong Luo, Yanqiu Chen, Changzhi Sun, Jie Wang, Lifeng Zhou, Yan Li, Li Deng
Pediatric Research.2015; 77(1): 20. CrossRef
The Transforming Growth Factor β1/Interleukin-31 Pathway Is Upregulated in Patients with Hepatitis B Virus-Related Acute-on-Chronic Liver Failure and Is Associated with Disease Severity and Survival
Xueping Yu, Ruyi Guo, Desong Ming, Yong Deng, Milong Su, Chengzu Lin, Julan Li, Zhenzhong Lin, Zhijun Su, R. L. Hodinka
Clinical and Vaccine Immunology.2015; 22(5): 484. CrossRef
NFAT1 and JunB Cooperatively Regulate IL-31 Gene Expression in CD4+ T Cells in Health and Disease
Ji Sun Hwang, Gi-Cheon Kim, EunBee Park, Jung-Eun Kim, Chang-Suk Chae, Won Hwang, Changhon Lee, Sung-Min Hwang, Hui Sun Wang, Chang-Duk Jun, Dipayan Rudra, Sin-Hyeog Im
The Journal of Immunology.2015; 194(4): 1963. CrossRef
Interleukin-31: A Novel Diagnostic Marker of Allergic Diseases
Anja Rabenhorst, Karin Hartmann
Current Allergy and Asthma Reports.2014;[Epub] CrossRef
Role of IL-31 in regulation of Th2 cytokine levels in patients with nasal polyps
Hong Ouyang, Jie Cheng, Yajun Zheng, Jingdong Du
European Archives of Oto-Rhino-Laryngology.2014; 271(10): 2703. CrossRef
Polymorphisms of interleukin-31 are associated with anti-CCP levels in females with rheumatoid arthritis
JI-IN YU, YOUNG-RAN PARK, SHIN-SEOK LEE, SOO-CHEON CHAE
Journal of Genetics.2014; 93(3): 813. CrossRef
IL-31 Associated with Coronary Artery Lesion Formation in Kawasaki Disease
Wan-Ning Tseng, Mao-Hung Lo, Mindy Ming-Huey Guo, Kai-Sheng Hsieh, Wei-Chiao Chang, Ho-Chang Kuo, Chien-Sheng Chen
PLoS ONE.2014; 9(8): e105195. CrossRef

The Clinicopathologic Features of Molecular Apocrine Breast Cancer: Yoon Jin Cha, Woo-Hee Jung, Ja Seung Koo; Korean J Pathol. 2012;46(2):169-176. Published online April 25, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.2.169

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Abstract PDF

Background

To elucidate the clinicopathologic features and their implications on the immunohistochemistry in cases of molecular apocrine breast cancer (MABC).

Methods

Immunohistochemical (IHC) staining for estrogen receptor (ER), human epidermal growth factor receptor 2 (HER-2), cytokeratin (CK) 5/6, epidermal growth factor receptor (EGFR), androgen receptor (AR), gamma-glutamyltrasferase 1 (GGT1) and Ki-67 was performed on tissue microarray breast cancer samples from 204 patients. Phenotypes of breast cancer were divided based on the IHC status of ER, AR and GGT1 into the following: luminal type, ER positive and AR and/or GGT1 positive; basal type, ER, AR, and GGT1 negative; non-basal type, ER positive and AR and GGT1 negative; and MABC type, ER negative and AR and/or GGT1 positive.

Results

In our series of patients (n=204), there were 26 cases of MABC. Besides, there were 18, 60, and 100 cases of luminal type, basal type and non-basal type, respectively. The MABC demonstrated apocrine histology and a higher prevalence of HER-2 positivity than other phenotypes. With the basal type, the MABC manifested a more frequent expression of CK5/6 and EGFR and a higher Ki-67 index than other phenotypes (p<0.001). There were no significant differences in patient prognosis between the phenotypes of breast cancer.

Conclusions

MABC are distinguishable from other phenotypes based on the apocrine histology and a higher expression rate of HER-2.

Citations

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The role of histopathologic testing on apocrine carcinoma of the breast
Burak Ilhan, Selman Emiroğlu, Rustu Türkay, Rıdvan Ilhan
Current Problems in Cancer.2020; 44(2): 100501. CrossRef
Cancer du sein triple négatif exprimant le récepteur aux androgènes : de la biologie à la thérapeutique
Thomas Grellety
Bulletin du Cancer.2020; 107(4): 506. CrossRef
Triple‐negative apocrine carcinoma: A rare pathologic subtype with a better prognosis than other triple‐negative breast cancers
Cletus A. Arciero, Albert H. Diehl, Yuan Liu, Qin Sun, Theresa Gillespie, Xiaoxian Li, Preeti Subhedar
Journal of Surgical Oncology.2020; 122(6): 1232. CrossRef
Apocrine lesions of the breast: part 2 of a two-part review. Invasive apocrine carcinoma, the molecular apocrine signature and utility of immunohistochemistry in the diagnosis of apocrine lesions of the breast
Clare D'Arcy, Cecily M Quinn
Journal of Clinical Pathology.2019; 72(1): 7. CrossRef
Enhancing Abiraterone Acetate Efficacy in Androgen Receptor–positive Triple-negative Breast Cancer: Chk1 as a Potential Target
Thomas Grellety, Celine Callens, Elodie Richard, Adrien Briaux, Valérie Vélasco, Marina Pulido, Anthony Gonçalves, Pierre Gestraud, Gaetan MacGrogan, Hervé Bonnefoi, Bruno Cardinaud
Clinical Cancer Research.2019; 25(2): 856. CrossRef
A clinicopathologic study of invasive apocrine carcinoma of the breast: A single-center experience
Denira Imamovic, Nurija Bilalovic, Faruk Skenderi, Vanesa Beslagic, Timur Ceric, Berisa Hasanbegovic, Semir Beslija, Semir Vranic
The Breast Journal.2018; 24(6): 1105. CrossRef
Dose invasive apocrine adenocarcinoma has worse prognosis than invasive ductal carcinoma of breast: evidence from SEER database
Ning Zhang, Hanwen Zhang, Tong Chen, Qifeng Yang
Oncotarget.2017; 8(15): 24579. CrossRef
Pure Apocrine Carcinomas Represent a Clinicopathologically Distinct Androgen Receptor–Positive Subset of Triple-Negative Breast Cancers
Anne M. Mills, Chelsea E. Gottlieb, Scott M. Wendroth, Christiana M. Brenin, Kristen A. Atkins
American Journal of Surgical Pathology.2016; 40(8): 1109. CrossRef
Androgen Receptor: A Complex Therapeutic Target for Breast Cancer
Ramesh Narayanan, James Dalton
Cancers.2016; 8(12): 108. CrossRef
Early versus late distant metastasis and adjuvant chemotherapy alone versus both radiotherapy and chemotherapy in molecular apocrine breast cancer
Xiaozhen Liu, Yang Yang, Xiaolong Feng, Honghong Shen, Jian Liu, Xia Liu, Yun Niu
Oncotarget.2016; 7(31): 48905. CrossRef
Molecular and diagnostic features of apocrine breast lesions
Pavel Gromov, Jaime A Espinoza, Irina Gromova
Expert Review of Molecular Diagnostics.2015; 15(8): 1011. CrossRef
Prevalencia de receptores androgénicos en el cáncer de mama
Claudia Janeth Rodríguez-Silva, José Luis González-Vela, Ascary Alcides Velázquez-Pacheco
Gaceta Mexicana de Oncología.2015; 14(3): 135. CrossRef

Expression of Human Papillomavirus-Related Proteins and Its Clinical Implication in Tonsillar Squamous Cell Carcinoma: Joon Seon Song, Min-Sik Kim, Joon Wook Park, Youn Soo Lee, Chang Suk Kang; Korean J Pathol. 2012;46(2):177-186. Published online April 25, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.2.177

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Abstract PDF

Background

Human papillomavirus (HPV) is known to cause of oropharyngeal squamous cell carcinoma (SqCC). HPV positive SqCCs overexpress p16 and are associated with better survival. Several markers of cell cycles and apoptosis have been reported as a prognostic value. We examined the prognostic value of HPV status, p16, cyclin D1, and Bcl-2 in patients with tonsillar SqCC.

Methods

Tissue microarrays were constructed in 56 cases of tonsillar SqCC for which we performed an immunohistochemistry and an in situ hybridization (ISH) of the HPV.

Results

Of the 56 cases, 31 (55.3%) were positive for p16 and 20 (35.7%) were positive for HPV ISH. The expressions of p16, cyclin D1, and Bcl-2 were not correlated with the clinicopathologic variables including smoking status, differentiation and pT- and pN-stages. The HPV ISH positive group showed a better overall survival than the HPV negative group (p=0.04), and the p16 positive group showed a better disease free survival (DFS) than the negative group (p=0.016). Cox regression analysis showed that only p16 positivity was an independent prognostic factor for DFS (p=0.03; hazard ratio, 10.1).

Conclusions

Our results indicate that both p16 expression and HPV status are useful indicators for risk stratification in patients with tonsillar SqCC.

Citations

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Positive Rate of Human Papillomavirus and Its Trend in Head and Neck Cancer in South Korea
Hyun Woong Jun, Yong Bae Ji, Chang Myeon Song, Jae Kyung Myung, Hae Jin Park, Kyung Tae
Frontiers in Surgery.2022;[Epub] CrossRef
Negative Prognostic Implication of TERT Promoter Mutations in Human Papillomavirus–Negative Tonsillar Squamous Cell Carcinoma Under the New 8th AJCC Staging System
Hyunchul Kim, Mi Jung Kwon, Bumjung Park, Hyo Geun Choi, Eun Sook Nam, Seong Jin Cho, Kyueng-Whan Min, Eun Soo Kim, Hee Sung Hwang, Mineui Hong, Taeryool Koo, Hyo Jung Kim
Indian Journal of Surgical Oncology.2021; 12(S1): 134. CrossRef
In situ hybridization for high risk HPV E6/E7 mRNA in oropharyngeal squamous cell carcinoma
Krish Suresh, Parth V. Shah, Sydney Coates, Borislav A. Alexiev, Sandeep Samant
American Journal of Otolaryngology.2021; 42(1): 102782. CrossRef
Prevalence of high-risk human papillomavirus and its genotype distribution in head and neck squamous cell carcinomas
Yuil Kim, Young-Hoon Joo, Min-Sik Kim, Youn Soo Lee
Journal of Pathology and Translational Medicine.2020; 54(5): 411. CrossRef
Human Papillomavirus Testing in Head and Neck Carcinomas: Guideline From the College of American Pathologists
James S. Lewis, Beth Beadle, Justin A. Bishop, Rebecca D. Chernock, Carol Colasacco, Christina Lacchetti, Joel Todd Moncur, James W. Rocco, Mary R. Schwartz, Raja R. Seethala, Nicole E. Thomas, William H. Westra, William C. Faquin
Archives of Pathology & Laboratory Medicine.2018; 142(5): 559. CrossRef
Detection of HPV infection in head and neck cancers: Promise and pitfalls in the last ten years: A meta-analysis
Carolin G�tz, Clara Bischof, Klaus-Dietrich Wolff, Andreas Kolk
Molecular and Clinical Oncology.2018;[Epub] CrossRef
Frequent hepatocyte growth factor overexpression and low frequency of c-Met gene amplification in human papillomavirus–negative tonsillar squamous cell carcinoma and their prognostic significances
Mi Jung Kwon, Dong Hoon Kim, Hye-Rim Park, Hyung Sik Shin, Ji Hyun Kwon, Dong Jin Lee, Jin Hwan Kim, Seong Jin Cho, Eun Sook Nam
Human Pathology.2014; 45(7): 1327. CrossRef
Human papillomavirus‐stratified analysis of the prognostic role of miR‐21 in oral cavity and oropharyngeal squamous cell carcinoma
Yoon Ho Ko, Hye Sung Won, Der Sheng Sun, Ho Jung An, Eun Kyoung Jeon, Min Sik Kim, Han Hong Lee, Jin Hyoung Kang, Chan Kwon Jung
Pathology International.2014; 64(10): 499. CrossRef
Human Papillomavirus Prevalence and Cell Cycle Related Protein Expression in Tonsillar Squamous Cell Carcinomas of Korean Patients with Clinicopathologic Analysis
Miji Lee, Sung Bae Kim, Sang-wook Lee, Jong-Lyel Roh, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim, Kyung-Ja Cho
Korean Journal of Pathology.2013; 47(2): 148. CrossRef

Case Reports

Primary Monophasic Synovial Sarcoma Arising in the Mesentery: Case Report of an Extremely Rare Mesenteric Sarcoma Confirmed by Molecular Detection of a SYT-SSX2 Fusion Transcript: Han Suk Ryu, Ilyeong Heo, Jae Soo Koh, Sung-Ho Jin, Hye Jin Kang, Soo Youn Cho; Korean J Pathol. 2012;46(2):187-191. Published online April 25, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.2.187

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Abstract PDF

Synovial sarcoma arises in the para-articular tissues, and it can also occur in various unexpected sites. We report a rare case of primary monophasic synovial sarcoma (MSS) arising in the mesentery. A 59-year-old man presented with a palpable abdominal mass. On microscopic examination, the entire tumor comprised a dense proliferation of the spindle cells without epithelial components. The tumor cells were positive for transducin-like enhancer of split 1, bcl-2, epithelial membrane antigen and CD99 but negative for CD34, CD117, alpha-smooth muscle actin, cytokeratin, and calretinin on immunohistochemistry. The reverse transcriptase-polymerase chain reaction revealed a single 151-bp fragment representing the SYT-SSX2 fusion transcript. Because mesenteric MSS is extremely rare and many cases display histologic findings that overlap with those of more frequently involved tumors such as hemangiopericytoma and gastrointestinal stromal tumor, there is a chance of making an incorrect diagnosis that can result in an inappropriate treatment.

Citations

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A case of primary mesenteric synovial sarcoma: a challenging presentation
Nihed Abdessayed, Malek Barka, Samiha Mabrouk, Zeineb Nfikha, Zeineb Maatoug, Yosra Fejji, Mohamed Salah Jarrar, Sabri Youssef, Moncef Mokni
Surgical Case Reports.2023;[Epub] CrossRef
Giant solitary fibrous tumor of the pelvis: A case report and review of literature
Gerardo Palmieri, Carmine Grassi, Luigi Conti, Filippo Banchini, Maria Diletta Daccò, Gaetano M. Cattaneo, Patrizio Capelli
International Journal of Surgery Case Reports.2020; 77: S52. CrossRef
Tumeur neuroectodermique gastro-intestinale (GNET) : à propos d’un cas de tumeur du grêle avec métastases hépatiques
Thibault Kervarrec, Claire Lecointre, Rémy Kerdraon, Guido Bens, Arnaud Piquard, Patrick Michenet
Annales de Pathologie.2015; 35(6): 506. CrossRef

Ectomesenchymal Chondromyxoid Tumor in the Anterior Tongue: Case Report of a Unique Tumor: Min Gyoung Pak, Kyung Bin Kim, Nari Shin, Woo Kyung Kim, Dong Hoon Shin, Kyung Un Choi, Mee Young Sol; Korean J Pathol. 2012;46(2):192-196. Published online April 25, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.2.192

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Abstract PDF

Ectomesenchymal chondromyxoid tumor (ECMT) is a rare tumor, exclusively arising in the anterior tongue. Thirty-eight cases have been reported in the English literature. It usually presents as a sessile protrusion and shows round to spindle cells embedded in myxoid to chondroid stroma. Tumor cells are almost always positive for polyclonal glial fibrillary acidic protein (GFAP). We report our experience in the recent treatment of a case of ECMT, the third case in 3 years. The mass in the anterior tongue revealed characteristic morphologic features of ECMT and the expression of polyclonal GFAP. Although ECMT should be differentiated from other mesenchymal tumors including myoepithelioma, its clinical, morphological, and immunohistochemical features enable its diagnosis, especially when pathologists are aware of it.

Citations

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Ectomesenchymal chondromyxoid tumor of the oral cavity: a report of 5 new cases with comprehensive review of the literature and clinicohistopathologic features
Molly Housley Smith, Jack Moynihan
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.2023; 135(3): 410. CrossRef
Chondroid choristoma of the tongue: A rare case report
Sumaiya Nezam, Roquaiya Nishat, ShababAhmed Khan, JeevendraNath Shukla
National Journal of Maxillofacial Surgery.2022; 13(4): 121. CrossRef
Ectomesenchymal chondromyxoid tumor: a comprehensive updated review of the literature and case report
Astrid Truschnegg, Stephan Acham, Lumnije Kqiku, Norbert Jakse, Alfred Beham
International Journal of Oral Science.2018;[Epub] CrossRef
Clinical features of ectomesenchymal chondromyxoid tumors: A systematic review of the literature
Masanari G. Kato, Evren Erkul, Kendall S. Brewer, Emily E. Harruff, Shaun A. Nguyen, Terry A. Day
Oral Oncology.2017; 67: 192. CrossRef
Cyclin D1 Expression in Ectomesenchymal Chondromyxoid Tumor of the Anterior Tongue
Jan Laco, Radovan Mottl, Walter Höbling, Stephan Ihrler, Petr Grossmann, Alena Skalova, Ales Ryska
International Journal of Surgical Pathology.2016; 24(7): 586. CrossRef
Nodular lesion in the buccal mucosa
Bruna Jalfim Maraschin, Ana Carolina Amorim Pellicioli, Lélia Batista de Souza, Pantelis Varvaki Rados, Marco Antonio Trevizani Martins, Manoela Domingues Martins
The Journal of the American Dental Association.2015; 146(3): 196. CrossRef

Parathyromatosis: Critical Diagnosis Regarding Surgery and Pathologic Evaluation: Ayşegül Aksoy-Altinboga, Ayşegül Akder Sari, Türkan Rezanko, Mehmet Haciyanli, Aylin Orgen Calli; Korean J Pathol. 2012;46(2):197-200. Published online April 25, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.2.197

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Abstract PDF

Parathyromatosis, in which several nodules of hyperfunctioning parathyroid tissue form in the neck and mediastinum, is a rare cause of recurrent hyperparathyroidism. However, there are some theories regarding the origin of parathyromatosis, and seeding after rupture of the parathyroid gland capsule during surgical removal of a parathyroid lesions is the most regarded one. Herein, we report a 41-year-old man who presented with multiple parathyroid nodules in and around the left thyroid lobe 5 years after parathyroid surgery for secondary hyperparathyroidism that was finally diagnosed as parathyromatosis. We discuss the differential diagnosis of parathyromatosis from other parathyroid tumors, particularly from parathyroid carcinoma, which is important in the management of a suspected lesion.

Citations

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Intractable Parathyromatosis despite extensive surgical interventions: A case report with literature review
Shada Khaled Bashantoof, Mansoor Abdulmajeed Alramadhan, Modhi Hamad Alawadh, Nada Abdulaziz Bin Samaih, Rania Abdullah Alshammari, Abdulsalam Aodah
International Journal of Surgery Case Reports.2024; 114: 109172. CrossRef
Late recurrence of a single gland primary hyperparathyroidism—Atypical parathyroid adenoma or misdiagnosed parathyroid carcinoma
Jessica Kotliarevskaia, Udo Siebolts, Henning Dralle, Frank Schuppert
Clinical Case Reports.2024;[Epub] CrossRef
Retrosternal parathyromatosis in a patient with prior total parathyroidectomy
Tariq Saleh, Marwan Alaswad, Abdullah Otry, Waleed Saleh
Journal of Surgical Case Reports.2023;[Epub] CrossRef
Histological alterations following fine‐needle aspiration for parathyroid adenoma: Incidence and diagnostic problems
Mitsuyoshi Hirokawa, Ayana Suzuki, Miyoko Higuchi, Toshitetsu Hayashi, Seiji Kuma, Akihiro Miya, Akira Miyauchi
Pathology International.2021; 71(6): 400. CrossRef
Parathyromatosis as a cause of recurrence primary hyperparathyroidism: A case report
Elena A. Ilyicheva, Gleb A. Bersenev
International Journal of Surgery Case Reports.2021; 80: 105689. CrossRef
Seguridad y rendimiento diagnóstico de la medición de PTH en el lavado del aspirado de lesiones sospechosas de adenomas de paratiroides
Florentino Carral, Ana Isabel Jiménez, Mariana Tomé, Javier Alvarez, Ana Díez, Concepción García, Vicente Vega, Carmen Ayala
Endocrinología, Diabetes y Nutrición.2021; 68(7): 481. CrossRef
Safety and diagnostic performance of parathyroid hormone assay in fine-needle aspirate in suspicious parathyroid adenomas
Florentino Carral, Ana Isabel Jiménez, Mariana Tomé, Javier Alvarez, Ana Díez, Concepción García, Vicente Vega, Carmen Ayala
Endocrinología, Diabetes y Nutrición (English ed.).2021; 68(7): 481. CrossRef
Persistent secondary hyperparathyroidism caused by parathyromatosis and supernumerary parathyroid glands in a patient on haemodialysis
Jun Yang, Jun Zhang, Ning-hu Liu, Hao Liu, Meng-jie Dong
BMC Nephrology.2020;[Epub] CrossRef
Parathyromatosis: A Rare Case of Recurrent Hyperparathyroidism Localized by Four-Dimensional Computed Tomography
Abraham E. Wei, Matthew R. Garrett, Ankur Gupta
AACE Clinical Case Reports.2019; 5(6): e384. CrossRef
Parathyromatosis: a very rare cause of recurrent primary hyperparathyroidism – case report and review of the literature
M Haciyanli, S Karaisli, S Gucek Haciyanli, A Atasever, D Arikan Etit, EO Gur, T Acar
The Annals of The Royal College of Surgeons of England.2019; 101(8): e178. CrossRef
Parathyromatose : une cause rare d’hyperparathyroïdie récidivante
I. Achour, S. Charfi, M.A. Chaabouni, A. Chakroun, F. Guermazi, B. Hammami, A. Ghorbel
La Revue de Médecine Interne.2017; 38(1): 61. CrossRef
Recurrent primary hyperparathyroidism due to Type 1 parathyromatosis
Monica Jain, David L. Krasne, Frederick R. Singer, Armando E. Giuliano
Endocrine.2017; 55(2): 643. CrossRef

Melanotic Oncocytic Metaplasia of the Nasopharynx: A Report of Three Cases and Review of the Literature: Joo Young Na, Yeong Hui Kim, Yoo Duk Choi, Ji Shin Lee; Korean J Pathol. 2012;46(2):201-204. Published online April 25, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.2.201

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Abstract PDF

Melanotic oncocytic metaplasia of the nasopharynx is a rare condition which is characterized by the presence of usually a small, brown to black colored pigmented lesion around the Eustachian tube opening. Although it is a benign lesion, it may be clinically misdiagnosed as malignant melanoma. Microscopically, melanotic oncocytic metaplasia is a combination of oncocytic metaplasia of the epithelium of the gland and melanin pigmentation in its cytoplasm. In our present study, we report three cases of melanotic oncocytic metaplasia of the nasopharynx. All the three cases occurred in men and were presented as multiple black pigmented lesions around the torus tubarius. Microscopically, mucous glands with diffuse oncocytic metaplasia and numerous black pigments were observed. No cellular atypia was observed. Immunohistochemically, the scattering of S-100 protein-positive, and human melanoma black 45-negative dendritic melanocytes was evident. This is the first report of cases of melanotic oncocytic metaplasia of the nasopharynx in Korea.

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Lesions that mimic malignant tumors in nasopharyngeal biopsies: case series of 10 years
Mine Ozsen, Ozlem Saraydaroglu, Selin Yirmibes, H. Hakan Coskun
Tumori Journal.2022; 108(2): 119. CrossRef
Melanotic Oncocytic Metaplasia of the Nasopharynx Seen as a Rare Form of Cystic Mass: A Case Report and Review of the Literature
Keun-Ik Yi, Yong-Wan Kim
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Melanotic Oncocytic Metaplasia of the Nasopharynx: A Case Report With Review of Literature
Hsing-Yu Chen, Mpendulo Felix Gule, I-Wei Chang
Ear, Nose & Throat Journal.2021; 100(5_suppl): 771S. CrossRef
Malignant Mucosal Melanoma of the Eustachian Tube With Extension Into the Ipsilateral External Ear Canal: A Case Report and Review of the Literature
Lifeng Li, Nyall R. London, Xiaohong Chen
Ear, Nose & Throat Journal.2021; 100(5_suppl): 730S. CrossRef
Melanotic oncocytic metaplasia of the nasopharynx: A case report discussing the pathogenesis of a lesion
Shina Sakaguchi, Hiromasa Takakura, Shin-ichi Hayashi, Akira Noguchi, Hirohiko Tachino, Hideo Shojaku, Johji Imura
Otolaryngology Case Reports.2021; 20: 100276. CrossRef
Oncocytic Cysts of the Nasopharynx: A Case Report
Joshua C. Hwang, Raj D. Dedhia, Joan E. Bernard, Toby O. Steele
Allergy & Rhinology.2020; 11: 215265672095659. CrossRef
Melanotic Oncocytic Metaplasia of the Nasopharynx in the Patient with Suspicious Hemoptysis: Case Report
Taek Yoon Cheong, Han Seong Kim, Ick Soo Choi
Journal of Rhinology.2020; 27(2): 140. CrossRef
Clinicopathological features of melanotic and non-melanotic oncocytic lesions of the nasopharynx
Joshua J.X. Li, Joanna K.M. Ng, Amy B.W. Chan
Pathology.2019; 51(6): 600. CrossRef
Melanotic oncocytic metaplasia of the nasopharynx
Keiichiro Uehara, Yu Usami, Yukihiro Imai, Michio Shimizu
Pathology International.2015; 65(3): 144. CrossRef

Invasive Cribriform Carcinoma Arising in Malignant Phyllodes Tumor of Breast: A Case Report: Yoomi Choi, Kyoung Yul Lee, Min Hye Jang, Hyesil Seol, Sung-Won Kim, So Yeon Park; Korean J Pathol. 2012;46(2):205-209. Published online April 25, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.2.205

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Abstract PDF

Phyllodes tumor is an uncommon fibroepithelial neoplasm of the breast. And it is characterized by expanded stroma with increased cellularity and elongated epithelium-lined clefts. Mammary carcinomas within phyllodes tumors have been rarely reported. To date, however, no reports have described the invasive cribriform carcinoma arising in malignant phyllodes tumor. Here, we report a 62-year-old woman who presented with a large breast mass. Microscopically, the mass was a typical malignant phyllodes tumor showing well developed leaf-like architecture and stromal overgrowth with high cellularity and nuclear pleomorphism. In a portion of the tumor, however, the epithelial component showed a cribriform pattern of proliferation in the absence of myoepithelial cells, suggestive of the invasive cribriform carcinoma. To our knowledge, this is rare and it is difficult to make a differential diagnosis of it. Here, we report our case with a review of literatures.

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Management of Concurrent Malignant Phyllodes Tumor and Invasive Breast Carcinoma
Jie Jane Chen, Iowis Zhu, Akshat Patel, Gregor Krings, Yunn-Yi Chen, Florence Yuen, Rita A. Mukhtar, Michelle Melisko, Lisa Singer, Catherine C. Park, Nicolas D. Prionas
Advances in Radiation Oncology.2024; 9(5): 101448. CrossRef
High-grade ductal carcinoma in-situ detected by microcalcification within borderline phyllodes tumor: Report of a case and literature review
Wing Nam Yuen, Joshua J.X. Li, Man Yi Chan, Gary M. Tse
Human Pathology Reports.2023; 31: 300697. CrossRef
Cribriform carcinoma arising in a benign phyllodes tumor
EliaShazniza Shaaya, Nurwahyuna Rosli, Nurismah MD Isa
Journal of Research in Medical Sciences.2023; 28(1): 16. CrossRef
Unexpectedly High Coexistence Rate of In Situ/Invasive Carcinoma In Phyllodes Tumors. 10-Year Retrospective and Review Study
Öykü Dila Gemci, Serdar Altınay, Rümeysa İlbar Tartar, Sina Ferahman
European Journal of Breast Health.2022; 18(4): 343. CrossRef
A Case of Phyllodes Tumor Combined with Lobular Carcinoma of the Breast with Microinvasion
Daiki IMANISHI, Satoru NODA, Tsutomu TAKASHIMA, Yukie TAUCHI, Shinya NOMURA, Hiroshi OHTANI, Noriko SAKAIDA
Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2022; 83(12): 2049. CrossRef
Invasive ductal carcinoma within borderline phyllodes tumor with lymph node metastases: A case report and review of the literature
DI WU, HAIPENG ZHANG, LIANG GUO, XU YAN, ZHIMIN FAN
Oncology Letters.2016; 11(4): 2502. CrossRef

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