Fig. 1Images of the hepatic lesion. (A) Precontrast computed tomography (CT) reveals an irregularly-shaped low-density lesion in segment 3 of the liver. (B) Portal phase CT demonstrats a multicystic lesion with thin enhancing septae. (C) T2-weighted turbo spin echo magnetic resonance imaging (MRI) (TR/TE; 911.8/80.0) shows a honeycomb-like lesion with a bright high signal intensity. (D) Contrast-enhanced T1-weighted MRI (TR/TE; 3.1/1.5) demonstrates thin enhancing septae without any enhancing solid portions.
Fig. 2Pathologic findings of the present case. (A) The cut surface of the cystic mass reveals a multicystic honeycomb appearance composed of many small cystic ductal structures. (B) Microscopically, this cystic nodule contains cystic ducts, periductal glands, and connective tissue. (C) Hepatic parenchyma is observed in the fibrous connective tissue between the cystic ducts. (D) These ducts are lined by a monolayer of cuboidal epithelial cells. Positive keratin 19 immunohistochemical staining of the lining epithelial cells and periductal glands (inset) are also noted.
Table 1.Clinicopathologic features of multicystic biliary hamartoma of the liver
Case No. |
Author |
Age/Sex |
Location |
Size (cm) |
Clinical symptoms |
Treatments |
1 |
Zen et al. [1] |
59/M |
Segment 4 |
4.2 |
Abdominal pain |
Left hepatectomy |
2 |
Zen et al. [1] |
70/F |
Segment 3 |
1.8 |
Liver dysfunction |
Segmentectomy |
3 |
Zen et al. [1] |
69/F |
Segment 3 |
2.8 |
Elevation of liver enzyme |
Segmentectomy |
4 |
Kai et al. [3] |
55/M |
Segment 6 |
5.0 |
Incidental |
Partial resection |
5 |
Ryu et al. [2] |
45/M |
Segment 7 |
2.0-3.5 (case nos. 5-7) |
Incidental |
Partial resection |
6 |
Ryu et al. [2] |
58/M |
Segment 3 |
- |
Incidental |
Partial resection |
7 |
Ryu et al. [2] |
55/F |
Segment 6/7 |
- |
Incidental |
Partial resection |
8 |
Kobayashi et al. [4] |
30/M |
Segment 6 |
3.6 |
Incidental |
Partial resection |
Present case |
|
52/M |
Segment 3 |
2.7 |
Abdominal discomfort |
Partial resection |