Skip Navigation
Skip to contents

JPTM : Journal of Pathology and Translational Medicine

OPEN ACCESS
SEARCH
Search

Previous issues

Page Path
HOME > Articles and issues > Previous issues
18 Previous issues
Filter
Filter
Article category
Keywords
Authors
Volume 46(1); February 2012
Prev issue Next issue
Review
CpG Island Hypermethylation in Gastric Carcinoma and Its Premalignant Lesions
Gyeong Hoon Kang
Korean J Pathol. 2012;46(1):1-9.   Published online February 23, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.1.1
  • 7,164 View
  • 43 Download
  • 17 Citations
AbstractAbstract PDF

Gastric cancers arise through a multistep process characterized by the progressive accumulation of molecular alterations in which genetic and epigenetic mechanisms have been implicated. Gastric cancer is one of the human malignancies in which aberrant promoter CpG island hypermethylation is frequently found. Helicobacter pylori and Epstein-Barr virus, which are known carcinogens for gastric cancer, are closely associated with enhanced hypermethylation of CpG island loci in gastric non-neoplastic epithelial cells and cancer cells, respectively. Aberrant CpG island hypermethylation occurs early in the multistep cascade of gastric carcinogenesis and tends to increase with the step-wise progression of the lesion. Approximately 400 genes that are actively expressed in normal gastric epithelial cells are estimated to be inactivated in gastric cancers as a result of promoter CpG island hypermethylation. In this review, a variety of information is summarized regarding CpG island hypermethylation in gastric cancer.

Citations

Citations to this article as recorded by  
  • Analysis of DNA methylation in endometrial biopsies to predict risk of endometrial cancer
    Francesco Multinu, Jun Chen, Joseph D. Madison, Michelle Torres, Jvan Casarin, Daniel Visscher, Viji Shridhar, Jamie Bakkum-Gamez, Mark Sherman, Nicolas Wentzensen, Andrea Mariani, Marina Walther-Antonio
    Gynecologic Oncology.2020; 156(3): 682.     CrossRef
  • Helicobacter pylori severely reduces expression of DNA repair proteins PMS2 and ERCC1 in gastritis and gastric cancer
    Yasir Raza, Ayaz Ahmed, Adnan Khan, Arif Ali Chishti, Syed Shakeel Akhter, Muhammad Mubarak, Carol Bernstein, Beryl Zaitlin, Shahana Urooj Kazmi
    DNA Repair.2020; 89: 102836.     CrossRef
  • Genomic and Epigenomic Profiling of High-Risk Intestinal Metaplasia Reveals Molecular Determinants of Progression to Gastric Cancer
    Kie Kyon Huang, Kalpana Ramnarayanan, Feng Zhu, Supriya Srivastava, Chang Xu, Angie Lay Keng Tan, Minghui Lee, Suting Tay, Kakoli Das, Manjie Xing, Aliya Fatehullah, Syed Muhammad Fahmy Alkaff, Tony Kiat Hon Lim, Jonathan Lee, Khek Yu Ho, Steven George Ro
    Cancer Cell.2018; 33(1): 137.     CrossRef
  • Decreased Methylation of IFNAR Gene Promoter from Peripheral Blood Mononuclear Cells Is Associated with Oxidative Stress in Chronic Hepatitis B
    Jing-wen Wang, Jing-wei Wang, Jun Zhang, Chen-si Wu, Yu Fang, Wei-wei Su, Yu-chen Fan, Kai Wang
    Journal of Interferon & Cytokine Research.2018; 38(11): 480.     CrossRef
  • Genomic landscape of gastric cancer: molecular classification and potential targets
    Jiawei Guo, Weiwei Yu, Hui Su, Xiufeng Pang
    Science China Life Sciences.2017; 60(2): 126.     CrossRef
  • Hypermethylation of the galectin-3 promoter is associated with poor prognosis of acute-on-chronic hepatitis B liver failure
    Jing Zhao, Yu-Chen Fan, Xin-Yuan Liu, Ze-Hua Zhao, Feng Li, Kai Wang
    Digestive and Liver Disease.2017; 49(6): 664.     CrossRef
  • Proteomics-Based Identification and Analysis of Proteins Associated with Helicobacter pylori in Gastric Cancer
    Jianjiang Zhou, Wenling Wang, Yuan Xie, Yan Zhao, Xian Chen, Wenjie Xu, Yan Wang, Zhizhong Guan, Hiromu Suzuki
    PLOS ONE.2016; 11(1): e0146521.     CrossRef
  • Lack of Correlation between Aberrant p16, RAR-β2, TIMP3, ERCC1, and BRCA1 Protein Expression and Promoter Methylation in Squamous Cell Carcinoma Accompanying Candida albicans-Induced Inflammation
    Yui Terayama, Tetsuro Matsuura, Kiyokazu Ozaki, Javier S Castresana
    PLOS ONE.2016; 11(7): e0159090.     CrossRef
  • Helicobacter pylori CagA induces tumor suppressor gene hypermethylation by upregulating DNMT1 via AKT-NFκB pathway in gastric cancer development
    Bao-gui Zhang, Lei Hu, Ming-de Zang, He-xiao Wang, Wei Zhao, Jian-fang Li, Li-ping Su, Zhifeng Shao, Xiaodong Zhao, Zheng-gang Zhu, Min Yan, Bingya Liu
    Oncotarget.2016; 7(9): 9788.     CrossRef
  • Promoter methylation status and expression of PPAR-γ gene are associated with prognosis of acute-on-chronic hepatitis B liver failure
    Ze-Hua Zhao, Yu-Chen Fan, Qi Zhao, Cheng-Yun Dou, Xiang-Fen Ji, Jing Zhao, Shuai Gao, Xin-You Li, Kai Wang
    Clinical Epigenetics.2015;[Epub]     CrossRef
  • Role of epigenetics in EBV regulation and pathogenesis
    Hans Helmut Niller, Zsófia Tarnai, Gábor Decsi, Ádám Zsedényi, Ferenc Bánáti, Janos Minarovits
    Future Microbiology.2014; 9(6): 747.     CrossRef
  • Helicobacter pylori Induces Hypermethylation of CpG Islands Through Upregulation of DNA Methyltransferase: Possible Involvement of Reactive Oxygen/Nitrogen Species
    Hye-Kyung Na, Jeong-Hwa Woo
    Journal of Cancer Prevention.2014; 19(4): 259.     CrossRef
  • Mallory–Denk Body (MDB) formation modulates ufmylation expression epigenetically in alcoholic hepatitis (AH) and non-alcoholic steatohepatitis (NASH)
    Hui Liu, Ming Gong, Barbara A. French, Jun Li, Brittany Tillman, Samuel W. French
    Experimental and Molecular Pathology.2014; 97(3): 477.     CrossRef
  • RETRACTED ARTICLE: Role of p16 gene promoter methylation in gastric carcinogenesis: a meta-analysis
    He-Ling Wang, Ping-Yi Zhou, Peng Liu, Yu Zhang
    Molecular Biology Reports.2014; 41(7): 4481.     CrossRef
  • Exportin 4 gene expression and DNA promoter methylation status in chronic hepatitis B virus infection
    F. Zhang, Y.-C. Fan, N.-N Mu, J. Zhao, F.-K. Sun, Z.-H. Zhao, S. Gao, K. Wang
    Journal of Viral Hepatitis.2014; 21(4): 241.     CrossRef
  • Microarray-based DNA methylation study of Ewing’s sarcoma of the bone
    HYE-RIM PARK, WOON-WON JUNG, HYUN-SOOK KIM, YONG-KOO PARK
    Oncology Letters.2014; 8(4): 1613.     CrossRef
  • Pathologic Diagnosis of Gastric Intestinal Metaplasia
    Nari Shin, Do Youn Park
    The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2013; 13(2): 84.     CrossRef
Original Articles
Clinicopathologic Features of Q Fever Patients with Acute Hepatitis
Miji Lee, Jae Jeong Jang, Yang Soo Kim, Sang-Oh Lee, Sang-Ho Choi, Sung-Han Kim, Eunsil Yu
Korean J Pathol. 2012;46(1):10-14.   Published online February 23, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.1.10
  • 7,634 View
  • 58 Download
  • 12 Citations
AbstractAbstract PDF
Background

Q fever caused by Coxiella burnetii presents with diverse clinical and pathological features including subclinical or cholestatic hepatitis. However, the pathological features of liver biopsies from patients with Q fever have not been well described.

Methods

Clinical features and pathological findings of liver biopsies were reviewed in seven cases of Q fever that were confirmed by serological, microbiological, or molecular tests.

Results

All cases presented with fever. Liver enzymes were mildly elevated except one case with marked hyperbilirubinemia. Characteristic fibrin ring granulomas were present in three cases, epithelioid granulomas with eosinophilic infiltration in two cases, extensive extravasated fibrins without ring configuration mimicking necrotizing granuloma in one case, and acute cholangitis without granuloma in one case. All cases were treated with antibiotics for 20 days. Six cases were completely cured, but one suffered from multiorgan failure.

Conclusions

C. burnetii infection is uncommon, but should always be considered in patients with acute hepatitis and fever. Because variable-sized circumferential or radiating fibrin deposition was a consistent feature of the present cases, Q fever can be strongly suggested by pathological features and confirmed by serological and/or molecular tests.

Citations

Citations to this article as recorded by  
  • The First Case of Coxiella Burnetti Infection Detected Through Bone Marrow Biopsy in Vietnam
    Do Thi Vinh An, Bui Thi Viet Ha, Dao Xuan Co, Vu Minh Tam, Le Thi Diem Tuyet, Vu Van Truong
    Clinical Pathology.2022; 15: 2632010X2210963.     CrossRef
  • Pathological study and molecular detection of zoonotic diseases in small ruminants at slaughter houses in Mymensingh, Bangladesh
    Nazneen Sultana, Munmun Pervin, Sajeda Sultana, Mahmuda Islam, Moutuza Mostaree, Mohammad Abu Hadi Noor Ali Khan
    Veterinary World.2022; : 2119.     CrossRef
  • The First Report of Coxiella burnetii as a Potential Neglected Pathogen of Acute Hepatitis of Unknown Causes in Egypt
    Mohamed A. El-Mokhtar, Ibrahim M. Sayed, Ayat M. Kamel, Ahmed Atef Mesalam, Elsayed A. Elgohary, Khaled Abo bakr Khalaf, Sara Adel, Azza Abo Elfadl, Walaa A. Khalifa, Haidi Karam-Allah Ramadan
    Microorganisms.2022; 10(11): 2168.     CrossRef
  • A case of coexistent acute severe alcoholic and Q fever hepatitis: The useful contribution of repeated liver biopsies
    Zampaglione Lucia, Bornand Aurélie , Goossens Nicolas , Ramer Lucas , Magini Giulia , Ongaro Marie , Cerny Andreas , Rubbia-Brandt Laura , Jean-Louis Frossard, Spahr Laurent
    Annals of Clinical Gastroenterology and Hepatology.2022; 6(1): 034.     CrossRef
  • (Seltene) infektiöse Hepatitiden als wichtige Differenzialdiagnose der unklaren Hepatopathie
    Michael Wührl, Marc Ringelhan, Ursula Ehmer, Jochen Schneider, Juliane Kager, Tobias Lahmer, Anna Schneider, Wilko Weichert, Carolin Mogler
    Die Pathologie.2022;[Epub]     CrossRef
  • Q-fever associated granulomatous hepatitis
    Nicolas Dauby, Maria Gomez Galdon, Isabel Montesinos, Marjan Van Esbroeck, Thomas Sersté
    International Journal of Infectious Diseases.2020; 95: 113.     CrossRef
  • Pathologic changes and immune responses against Coxiella burnetii in mice following infection via non-invasive intratracheal inoculation
    Xueyuan Hu, Yonghui Yu, Junxia Feng, Mengjiao Fu, Lupeng Dai, Zhiyu Lu, Wenbo Luo, Jinglin Wang, Dongsheng Zhou, Xiaolu Xiong, Bohai Wen, Baohua Zhao, Jun Jiao, Daniel E. Voth
    PLOS ONE.2019; 14(12): e0225671.     CrossRef
  • Fibrin Ring Granulomas in Checkpoint Inhibitor-induced Hepatitis
    Jamie Everett, Amitabh Srivastava, Joseph Misdraji
    American Journal of Surgical Pathology.2017; 41(1): 134.     CrossRef
  • Clinical and Genetic Features ofCoxiella burnetiiin a Patient with an Acute Febrile Illness in Korea
    Seung Hun Lee, Jung Yeon Heo, Hae Kyung Lee, Yeong Seon Lee, Hye Won Jeong, Seon Do Hwang
    Journal of Korean Medical Science.2017; 32(6): 1038.     CrossRef
  • Q Fever Presented as a Large Retroperitoneal Pseudotumoral Mass
    Behdokht Nowroozizadeh, Negar Haghighi Mehmandari, Nicolas Gallegos, Mari Perez-Rosendahl, Di Lu
    Case Reports in Pathology.2017; 2017: 1.     CrossRef
  • From Q Fever to Coxiella burnetii Infection: a Paradigm Change
    Carole Eldin, Cléa Mélenotte, Oleg Mediannikov, Eric Ghigo, Matthieu Million, Sophie Edouard, Jean-Louis Mege, Max Maurin, Didier Raoult
    Clinical Microbiology Reviews.2017; 30(1): 115.     CrossRef
  • Prolonged Pyrexia and Hepatitis: Q fever
    Caitlin Dugdale, Brian Chow, Evgeny Yakirevich, Erna Kojic, Bettina Knoll
    The American Journal of Medicine.2014; 127(10): 928.     CrossRef
The Ratio of Atypical Ductal Hyperplasia Foci to Core Numbers in Needle Biopsy: A Practical Index Predicting Breast Cancer in Subsequent Excision
Jeong-Ju Lee, Hee Jin Lee, Jun Kang, Jeong-Hyeon Jo, Gyungyub Gong
Korean J Pathol. 2012;46(1):15-21.   Published online February 23, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.1.15
  • 8,776 View
  • 38 Download
AbstractAbstract PDF
Background

Although core needle biopsy (CNB) is considered to be the standard technique for histological diagnosis of breast lesions, it is less reliable for diagnosing atypical ductal hyperplasia (ADH). We therefore assessed the characteristics of CNB-diagnosed ADH that are more likely to be associated with more advanced lesions on subsequent surgical excision.

Methods

We retrospectively examined 239 consecutive CNBs, 127 of which were diagnosed as ADH following surgical excision, performed at Asan Medical Center between 1995 and 2010. Archival slides were analyzed for the number of cores per specimen, the number of ADH foci, and the ratio of ADH foci to number of cores (FC ratio).

Results

We found that ADH foci in 3 or more cores (p=0.003) and the presence of ADH in 3 or more foci (p=0.002) were correlated with malignancy following excision lesion. Moreover, an FC>1.1 was significantly associated with malignancy in the subsequent excision (p=0.000).

Conclusions

Including the number of ADH foci, the number of cores involved according to ADH, FC ratio, and histologic type in a pathology report of CNB may help in making clinical decisions about surgical excision.

Chemotherapy-Associated Hepatopathy in Korean Colorectal Cancer Liver Metastasis Patients: Oxaliplatin-Based Chemotherapy and Sinusoidal Injury
Soo Jeong Nam, Jai Young Cho, Hye Seung Lee, Gheeyoung Choe, Ja June Jang, Yoo-Seok Yoon, Ho-Seong Han, Haeryoung Kim
Korean J Pathol. 2012;46(1):22-29.   Published online February 23, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.1.22
  • 6,632 View
  • 59 Download
  • 12 Citations
AbstractAbstract PDF
Background

Although chemotherapy-related hepatic injury has been reported in colorectal cancer liver metastasis (CRLM) patients, the morphologic changes caused by chemotherapeutic agents and the effect of chemotherapy on postoperative outcome remain ill-defined. A comprehensive review of the morphologic changes in the post-chemotherapy non-neoplastic liver was performed and the clinical effect of preoperative chemotherapy in CRLM patients was analyzed.

Methods

Hematoxylin-eosin, Masson's trichrome and reticulin-stained slides from non-neoplastic livers obtained from 89 CRLM patients were analyzed, and the clinicopathologic features were correlated with the status of chemotherapy exposure.

Results

Histopathologic features of sinusoidal injury (sinusoidal dilatation, centrilobular perivenular fibrosis, parenchymal extinction lesions, small vessel obliteration, and hepatocyte plate disruption) were significantly more frequent in oxaliplatin-exposed livers (p<0.05). The extent of sinusoidal dilatation was positively correlated with increasing numbers of chemotherapy cycles (p=0.022). Abnormal preoperative liver function tests were more frequently seen (p<0.05) and postoperative total bilirubin was higher in the chemotherapy group (p=0.008). Postoperative morbidity was more common in the chemotherapy group (p=0.044).

Conclusions

Sinusoidal injury is frequently seen in oxaliplatin-treated livers, and its presence, especially when extensive, should be documented in surgical pathology practice. The recognition of sinusoidal injury may provide helpful guidelines for surgeons in deciding the extent of hepatic resection.

Citations

Citations to this article as recorded by  
  • Model establishment and microarray analysis of mice with oxaliplatin‑induced hepatic sinusoidal obstruction syndrome
    Chen Zhu, Xinwei Cheng, Ping Gao, Qianyan Gao, Ximin Wang, Dong Liu, Xiuhua Ren, Chengliang Zhang
    Molecular Medicine Reports.2022;[Epub]     CrossRef
  • Oxaliplatin-induced hepatic sinusoidal obstruction syndrome
    Chen Zhu, Xiuhua Ren, Dong Liu, Chengliang Zhang
    Toxicology.2021; 460: 152882.     CrossRef
  • Hepatic steatosis in patients undergoing resection of colorectal liver metastases: A target for prehabilitation? A narrative review
    D.T. Doherty, P.O. Coe, L. Rimmer, S. Lapsia, A. Krige, D.A. Subar
    Surgical Oncology.2019; 30: 147.     CrossRef
  • Protective effect of Korean red ginseng on oxaliplatin-mediated splenomegaly in colon cancer
    Jeonghyun Kang, Joon Seong Park, Sung Gwe Ahn, Jin Hong Lim, Seung Hyuk Baik, Dong Sup Yoon, Kang Young Lee, Joon Jeong
    Annals of Surgical Treatment and Research.2018; 95(3): 161.     CrossRef
  • Use of Imaging to Predict Complete Response of Colorectal Liver Metastases after Chemotherapy: MR Imaging versus CT Imaging
    Min Jung Park, Nurhee Hong, Kyunghwa Han, Min Ju Kim, Yoon Jin Lee, Yang Shin Park, Sung Eun Rha, Sumi Park, Won Jae Lee, Seong Ho Park, Chang Hee Lee, Chung Mo Nam, Chansik An, Hye Jin Kim, Honsoul Kim, Mi-Suk Park
    Radiology.2017; 284(2): 423.     CrossRef
  • Systematic review of the influence of chemotherapy-associated liver injury on outcome after partial hepatectomy for colorectal liver metastases
    J Zhao, K M C van Mierlo, J Gómez-Ramírez, H Kim, C H C Pilgrim, P Pessaux, S S Rensen, E P van der Stok, F G Schaap, O Soubrane, T Takamoto, L Viganò, B Winkens, C H C Dejong, S W M Olde Damink, I García Sanz, E Martín Pérez, J Y Cho, Y R Choi, W Phillip
    British Journal of Surgery.2017; 104(8): 990.     CrossRef
  • Hepatic Lesions that Mimic Metastasis on Radiological Imaging during Chemotherapy for Gastrointestinal Malignancy: Recent Updates
    Sung-Hye You, Beom Jin Park, Yeul Hong Kim
    Korean Journal of Radiology.2017; 18(3): 413.     CrossRef
  • Changes in Noninvasive Liver Fibrosis Indices and Spleen Size During Chemotherapy
    Sehhoon Park, Hwi Young Kim, Haeryoung Kim, Jin Hyun Park, Jung Ho Kim, Ki Hwan Kim, Won Kim, In Sil Choi, Yong Jin Jung, Jin-Soo Kim
    Medicine.2016; 95(2): e2454.     CrossRef
  • Hepar lobatum carcinomatosum associated with liver metastases from breast cancer: Report of five cases
    N. Alberti, D. Bechade, F. Dupuis, A. Crombe, A. Neuville, M. Debled, J. Palussiere, X. Buy, J.-T. Perez, M. Desjardin, N. Frulio, M. Kind
    Diagnostic and Interventional Imaging.2015; 96(1): 73.     CrossRef
  • Sinusoidal obstruction syndrome after oxaliplatin-based chemotherapy
    An Na Seo, Haeryoung Kim
    Clinical and Molecular Hepatology.2014; 20(1): 81.     CrossRef
  • Chemotherapy-induced Focal Hepatopathy in Patients with Gastrointestinal Malignancy: Gadoxetic Acid–enhanced and Diffusion-weighted MR Imaging with Clinical-Pathologic Correlation
    Na Yeon Han, Beom Jin Park, Deuk Jae Sung, Min Ju Kim, Sung Bum Cho, Chang Hee Lee, Yun-Jin Jang, So Yeon Kim, Dong Sik Kim, Soon Ho Um, Nam Hee Won, Kyung Sook Yang
    Radiology.2014; 271(2): 416.     CrossRef
  • Histopathologic Manifestations of Drug-induced Hepatotoxicity
    Xuchen Zhang, Jie Ouyang, Swan N. Thung
    Clinics in Liver Disease.2013; 17(4): 547.     CrossRef
TNF-α and TNF-β Polymorphisms are Associated with Susceptibility to Osteoarthritis in a Korean Population
Lin Han, Joo Hyoun Song, Jung Hwan Yoon, Yong Gyu Park, Suk Woo Lee, Yoo Jin Choi, Suk Woo Nam, Jung Young Lee, Won Sang Park
Korean J Pathol. 2012;46(1):30-37.   Published online February 23, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.1.30
  • 8,693 View
  • 40 Download
  • 24 Citations
AbstractAbstract PDF
Background

The tumor necrosis factor (TNF) is believed to play an important role in the pathophysiology of osteoarthritis (OA). Evidence shows that genetic polymorphisms make substantial contributions to the etiology of OA.

Methods

We investigated the genotypes TNF-α and TNF-β in 301 OA patients and 291 healthy subjects as controls. We employed a polymerase chain reaction-restriction fragment length polymorphism and a polymerase chain reaction-single strand conformation polymorphism assay to identify the genotypes TNFA -G308A and TNFB +G252A, respectively.

Results

For TNFA -G308A, the percentages of genotypes GG, AG, and AA were 26.3% (79/301), 62.5% (188/301), and 11.3% (34/301) in OA patients and 88.7% (258/291), 11.3% (33/291), and 0% (0/291) in controls. For TNFB +G252A, the percentages of genotypes GG, AG, and AA were 15.3% (46/301), 41.9% (126/301), and 42.9% (129/301) in OA patients and 12% (35/291), 52.6% (153/291), and 35.4% (103/291) in controls. There were significant differences in genotypes and alleles of TNFA -308 between OA patients and controls (p<0.0001) and in alleles of TNFB +252 (p=0.0325). The risk of OA was significantly higher for carriers of the TNFA -308A allele and the TNFB +252 AA homozygote (p=0.0224).

Conclusions

The results suggest close relationships between TNFA -G308A and TNFB +G252A polymorphisms and individual susceptibility to OA in the Korean population.

Citations

Citations to this article as recorded by  
  • Vitamin D Receptor Gene Polymorphisms and Risk of Knee Osteoarthritis: Possible Correlations with TNF-α, Macrophage Migration Inhibitory Factor, and 25-Hydroxycholecalciferol Status
    Mohammed H. Hassan, Amer Alkot Mostafa Elsadek, Marwa Ahmed Mahmoud, Bakheet E. M. Elsadek
    Biochemical Genetics.2022; 60(2): 611.     CrossRef
  • Health benefits of astaxanthin against age-related diseases of multiple organs: A comprehensive review
    Phaniendra Alugoju, V. K. D. Krishna Swamy, Naga Venkata Anusha Anthikapalli, Tewin Tencomnao
    Critical Reviews in Food Science and Nutrition.2022; : 1.     CrossRef
  • Complement System Inhibition Modulates the Inflammation Induced by the Venom of Premolis semirufa, an Amazon Rainforest Moth Caterpillar
    Joel J. M. Gabrili, Isadora Maria Villas-Boas, Giselle Pidde, Carla Cristina Squaiella-Baptistão, Trent M. Woodruff, Denise V. Tambourgi
    International Journal of Molecular Sciences.2022; 23(21): 13333.     CrossRef
  • Azilsartan prevented AGE‐induced inflammatory response and degradation of aggrecan in human chondrocytes through inhibition of Sox4
    Jie Lei, Mengyin He, Liangzhou Xu, Chengjian He, Jie Li, Wei Wang
    Journal of Biochemical and Molecular Toxicology.2021;[Epub]     CrossRef
  • TNF-α Carried by Plasma Extracellular Vesicles Predicts Knee Osteoarthritis Progression
    Xin Zhang, Ming-Feng Hsueh, Janet L. Huebner, Virginia B. Kraus
    Frontiers in Immunology.2021;[Epub]     CrossRef
  • Genetic association between TNF-α G-308A and osteoarthritis in Asians: A case–control study and meta-analysis
    Chih-Chien Wang, Chih-Yun Huang, Meng-Chang Lee, Dung-Jang Tsai, Chia-Chun Wu, Sui-Lung Su, Mingqing Xu
    PLOS ONE.2021; 16(11): e0259561.     CrossRef
  • Sex-, Age-, and Metabolic Disorder-Dependent Distributions of Selected Inflammatory Biomarkers among Community-Dwelling Adults
    So Mi Jemma Cho, Hokyou Lee, Jee-Seon Shim, Hyeon Chang Kim
    Diabetes & Metabolism Journal.2020; 44(5): 711.     CrossRef
  • Tumor necrosis factor-α: Molecular assessment of gene expression, genetic variants and serum level in Egyptian patients with knee osteoarthritis
    Nermin Raafat, Amal F. Gharib, Doaa S. Atta, Shimaa M. AbdElwahab, Doaa M. Sharaf
    Gene Reports.2020; 21: 100922.     CrossRef
  • Effect of a functional variant of tumor necrosis factor-β gene in temporomandibular disorders: A pilot study
    Kaan Yerliyurt, Ayse Feyda Nursal, Akin Tekcan, Nevin Karakus, Mehmet K. Tumer, Serbulent Yigit
    Journal of Clinical Laboratory Analysis.2019; 33(1): e22641.     CrossRef
  • Interleukin-6 (-572) and Tumor Necrosis Factor α (-308 and -238) Polymorphisms and Risk of Knee Osteoarthritis in a Pakistani Population: A Case–Control Study
    Syeda Kanwal Batool Naqvi, Maria Bibi, Iram Murtaza, Qamar Javed
    Iranian Journal of Science and Technology, Transactions A: Science.2019; 43(4): 1485.     CrossRef
  • Role of resistin genetic variations in knee osteoarthritis pathogenesis, a cross sectional study
    Syeda Kanwal Batool Naqvi, Iram Murtaza, Qamar Javed
    Molecular Biology Reports.2019; 46(3): 2657.     CrossRef
  • Relationship Between Genetic Polymorphisms of the TNF Gene and Hallux Valgus Susceptibility
    Jie Yang, Junhu Wang, Xiaojun Liang, Hongmou Zhao, Jun Lu, Qiang Ma, Feng Tian
    Genetic Testing and Molecular Biomarkers.2019; 23(6): 380.     CrossRef
  • Functional status and severity of osteoarthritis in elderly is associated to the polymorphism of TNFA gene
    Marcos Tadeu Parron Fernandes, Karen Barros Parron Fernandes, Fernanda Freitas Anibal, Walquíria Shimoya-Bittencourt, Viviane Martins Santos, Priscila Daniele de Oliveira Perrucini, Regina Célia Poli-Frederico
    Advances in Rheumatology.2019;[Epub]     CrossRef
  • Association of TNF-α-308 G > A and −238G > A polymorphisms with knee osteoarthritis risk: A case-control study and meta-analysis
    Mohammad Reza Sobhan, Masoud Mahdinezhad-Yazdi, Kazem Aghili, Masoud Zare-Shehneh, Shohreh Rastegar, Jalal Sadeghizadeh-Yazdi, Hossein Neamatzadeh
    Journal of Orthopaedics.2018; 15(3): 747.     CrossRef
  • Association between tumor necrosis factor alpha rs1800629 polymorphism and risk of osteoarthritis in a Chinese population
    Jie Chen, Yu Wu, Jiannong Yu, Jinming Shen
    Brazilian Journal of Medical and Biological Research.2018;[Epub]     CrossRef
  • Association of cytokine gene polymorphisms with osteoarthritis susceptibility
    Otilia Rogoveanu, Daniela Calina, Mihai Cucu, Florin Burada, Anca Docea, Simona Sosoi, Emilian Stefan, Mihai Ioana, Emilia Burada
    Experimental and Therapeutic Medicine.2018;[Epub]     CrossRef
  • TNF‑α increases the expression of inflammatory factors in synovial fibroblasts by inhibiting the PI3K/AKT pathway in a rat model of monosodium iodoacetate‑induced osteoarthritis
    Hongxi Li, Shujuan Xie, Yunlong Qi, Huazhe Li, Rui Zhang, Yongyun Lian
    Experimental and Therapeutic Medicine.2018;[Epub]     CrossRef
  • The single-nucleotide polymorphism (SNP) of tumor necrosis factor α −308G/A gene is associated with early-onset primary knee osteoarthritis in an Egyptian female population
    Sahar M. Abdel Galil, Nillie Ezzeldin, Faten Fawzy, Mohamed El-Boshy
    Clinical Rheumatology.2017; 36(11): 2525.     CrossRef
  • Roxatidine Attenuates Degradation of Extracellular Matrix
    Renhao Ze, Shangyu Wang, Mao Xie, Bo Zhang, Xin Tang, Jin Li
    Biomedicine & Pharmacotherapy.2017; 95: 1156.     CrossRef
  • The Role of Inflammatory and Anti-Inflammatory Cytokines in the Pathogenesis of Osteoarthritis
    Piotr Wojdasiewicz, Łukasz A. Poniatowski, Dariusz Szukiewicz
    Mediators of Inflammation.2014; 2014: 1.     CrossRef
  • Meta-analysis of tumor necrosis factor alpha -308 polymorphism and knee osteoarthritis risk
    Suotang Kou, Yaochi Wu
    BMC Musculoskeletal Disorders.2014;[Epub]     CrossRef
  • Astaxanthin reduces matrix metalloproteinase expression in human chondrocytes
    Wei-Ping Chen, Yan Xiong, Yong-Xiang Shi, Peng-Fei Hu, Jia-Peng Bao, Li-Dong Wu
    International Immunopharmacology.2014; 19(1): 174.     CrossRef
  • Variations in the TNFα gene and their interactions with the IL4R and IL10 genes in relation to hand osteoarthritis
    Satu Hämäläinen, Svetlana Solovieva, Tapio Vehmas, Päivi Leino-Arjas, Ari Hirvonen
    BMC Musculoskeletal Disorders.2014;[Epub]     CrossRef
  • Association analysis of two candidate polymorphisms in the Tumour Necrosis Factor-α gene with osteoarthritis in a Chinese population
    Bin Ji, Jixiang Shi, Xiangyu Cheng, Junjie Zhou, Qiang Zhou, Chengfu Cao, Jinhui Pang
    International Orthopaedics.2013; 37(10): 2061.     CrossRef
Nuclear Image Analysis Study of Neuroendocrine Tumors
Meeja Park, Taehwa Baek, Jongho Baek, Hyunjin Son, Dongwook Kang, Jooheon Kim, Hyekyung Lee
Korean J Pathol. 2012;46(1):38-41.   Published online February 23, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.1.38
  • 5,474 View
  • 24 Download
  • 2 Citations
AbstractAbstract PDF
Background

There is a subjective disagreement about nuclear chromatin in the field of pathology. Objective values of red, green, and blue (RGB) light intensities for nuclear chromatin can be obtained through a quantitative analysis using digital images.

Methods

We examined 10 cases of well differentiated neuroendocrine tumors of the rectum, small cell lung carcinomas, and moderately differentiated squamous cell lung carcinomas respectively. For each case, we selected 30 representative cells and captured typical microscopic findings. Using an image analyzer, we determined the longest nuclear line profiles and obtained graph files and Excel data on RGB light intensities. We assessed the meaningful differences in graph files and Excel data among the three different tumors.

Results

The nucleus of hematoxylin and eosin-stained tumor cells was expressed as a combination of RGB light sources. The highest intensity was from blue, whereas the lowest intensity was from green. According to the graph files, green showed the most noticeable change in the light intensity, which is consistent with the difference in standard deviations.

Conclusions

The change in the light intensity for green has an important implication for differentiating between tumors. Specific features of the nucleus can be expressed in specific values of RGB light intensities.

Citations

Citations to this article as recorded by  
  • Difference of the Nuclear Green Light Intensity between Papillary Carcinoma Cells Showing Clear Nuclei and Non-neoplastic Follicular Epithelia in Papillary Thyroid Carcinoma
    Hyekyung Lee, Tae Hwa Baek, Meeja Park, Seung Yun Lee, Hyun Jin Son, Dong Wook Kang, Joo Heon Kim, Soo Young Kim
    Journal of Pathology and Translational Medicine.2016; 50(5): 355.     CrossRef
  • Comparison of diagnostic accuracy between CellprepPlus® and ThinPrep® liquid-based preparations in effusion cytology
    Yong-Moon Lee, Ji-Yong Hwang, Seung-Myoung Son, Song-Yi Choi, Ho-Chang Lee, Eun-Joong Kim, Hye-Suk Han, Jin young An, Joung-Ho Han, Ok-Jun Lee
    Diagnostic Cytopathology.2014; 42(5): 384.     CrossRef
Interobserver Variability in Diagnosing High-Grade Neuroendocrine Carcinoma of the Lung and Comparing It with the Morphometric Analysis
Seung Yeon Ha, Joungho Han, Wan-Seop Kim, Byung Seong Suh, Mee Sook Roh
Korean J Pathol. 2012;46(1):42-47.   Published online February 23, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.1.42
  • 6,675 View
  • 43 Download
  • 17 Citations
AbstractAbstract PDF
Background

Distinguishing small cell lung carcinoma (SCLC) and large cell neuroendocrine carcinoma (LCNEC) of the lung is difficult with little information about interobserver variability.

Methods

One hundred twenty-nine cases of resected SCLC and LCNEC were independently evaluated by four pathologists and classified according to the 2004 World Health Organization criteria. Agreement was regarded as "unanimous" if all four pathologists agreed on the classification. The kappa statistic was calculated to measure the degree of agreement between pathologists. We also measured cell size using image analysis, and receiver-operating-characteristic curve analysis was performed to evaluate cell size in predicting the diagnosis of high-grade neuroendocrine (NE) carcinomas in 66 cases.

Results

Unanimous agreement was achieved in 55.0% of 129 cases. The kappa values ranged from 0.35 to 0.81. Morphometric analysis reaffirmed that there was a continuous spectrum of cell size from SCLC to LCNEC and showed that tumors with cells falling in the middle size range were difficult to categorize and lacked unanimous agreement.

Conclusions

Our results provide an objective explanation for considerable interobserver variability in the diagnosis of high-grade pulmonary NE carcinomas. Further studies would need to define more stringent and objective definitions of cytologic and architectural characteristics to reliably distinguish between SCLC and LCNEC.

Citations

Citations to this article as recorded by  
  • Genomic Feature of a Rare Case of Mix Small-Cell and Large-Cell Neuroendocrine Lung Carcinoma: A Case Report
    Youcai Zhu, Feng Zhang, Dong Yu, Fang Wang, Manxiang Yin, Liangye Chen, Chun Xiao, Yueyan Huang, Feng Ding
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Small-Cell Carcinoma of the Lung: What We Learned about It?
    Luisella Righi, Marco Volante, Mauro Papotti
    Acta Cytologica.2022; 66(4): 257.     CrossRef
  • Hierarchical identification of a transcriptional panel for the histological diagnosis of lung neuroendocrine tumors
    Juxuan Zhang, Jiaxing Deng, Xiao Feng, Yilong Tan, Xin Li, Yixin Liu, Mengyue Li, Haitao Qi, Lefan Tang, Qingwei Meng, Haidan Yan, Lishuang Qi
    Frontiers in Genetics.2022;[Epub]     CrossRef
  • Immunohistochemical Staining With Neuroendocrine Markers is Essential in the Diagnosis of Neuroendocrine Neoplasms of the Esophagogastric Junction
    Dea N.M. Jepsen, Anne-Marie K. Fiehn, Rajendra S. Garbyal, Ulla Engel, Jakob Holm, Birgitte Federspiel
    Applied Immunohistochemistry & Molecular Morphology.2021; 29(6): 454.     CrossRef
  • Improving differential diagnosis of pulmonary large cell neuroendocrine carcinoma and small cell lung cancer via a transcriptomic, biological pathway-based machine learning model
    Junhong Guo, Likun Hou, Wei Zhang, Zhengwei Dong, Lei Zhang, Chunyan Wu
    Translational Oncology.2021; 14(12): 101222.     CrossRef
  • Are neuroendocrine negative small cell lung cancer and large cell neuroendocrine carcinoma with WT RB1 two faces of the same entity?
    Dmitriy Sonkin, Anish Thomas, Beverly A Teicher
    Lung Cancer Management.2019; 8(2): LMT13.     CrossRef
  • Ki-67 labeling index of neuroendocrine tumors of the lung has a high level of correspondence between biopsy samples and surgical specimens when strict counting guidelines are applied
    Alessandra Fabbri, Mara Cossa, Angelica Sonzogni, Mauro Papotti, Luisella Righi, Gaia Gatti, Patrick Maisonneuve, Barbara Valeri, Ugo Pastorino, Giuseppe Pelosi
    Virchows Archiv.2017; 470(2): 153.     CrossRef
  • The Use of Immunohistochemistry Improves the Diagnosis of Small Cell Lung Cancer and Its Differential Diagnosis. An International Reproducibility Study in a Demanding Set of Cases
    Erik Thunnissen, Alain C. Borczuk, Douglas B. Flieder, Birgit Witte, Mary Beth Beasley, Jin-Haeng Chung, Sanja Dacic, Sylvie Lantuejoul, Prudence A. Russell, Michael den Bakker, Johan Botling, Elisabeth Brambilla, Erienne de Cuba, Kim R. Geisinger, Kenzo
    Journal of Thoracic Oncology.2017; 12(2): 334.     CrossRef
  • Reply to Letter “The Use of Immunohistochemistry Improves the Diagnosis of Small Cell Lung Cancer and Its Differential Diagnosis. An International Reproducibility Study in a Demanding Set of Cases.”
    Erik Thunnissen, Birgit I. Witte, Masayuki Noguchi, Yasushi Yatabe
    Journal of Thoracic Oncology.2017; 12(6): e70.     CrossRef
  • What clinicians are asking pathologists when dealing with lung neuroendocrine neoplasms?
    Giuseppe Pelosi, Alessandra Fabbri, Mara Cossa, Angelica Sonzogni, Barbara Valeri, Luisella Righi, Mauro Papotti
    Seminars in Diagnostic Pathology.2015; 32(6): 469.     CrossRef
  • Unraveling Tumor Grading and Genomic Landscape in Lung Neuroendocrine Tumors
    Giuseppe Pelosi, Mauro Papotti, Guido Rindi, Aldo Scarpa
    Endocrine Pathology.2014; 25(2): 151.     CrossRef
  • Grading the neuroendocrine tumors of the lung: an evidence-based proposal
    G Rindi, C Klersy, F Inzani, G Fellegara, L Ampollini, A Ardizzoni, N Campanini, P Carbognani, T M De Pas, D Galetta, P L Granone, L Righi, M Rusca, L Spaggiari, M Tiseo, G Viale, M Volante, M Papotti, G Pelosi
    Endocrine-Related Cancer.2014; 21(1): 1.     CrossRef
  • Controversial issues and new discoveries in lung neuroendocrine tumors
    Giuseppe Pelosi, Kenzo Hiroshima, Mari Mino-Kenudson
    Diagnostic Histopathology.2014; 20(10): 392.     CrossRef
  • BAI3, CDX2 and VIL1: a panel of three antibodies to distinguish small cell from large cell neuroendocrine lung carcinomas
    Muhammad F Bari, Helen Brown, Andrew G Nicholson, Keith M Kerr, John R Gosney, William A Wallace, Irshad Soomro, Salli Muller, Danielle Peat, Jonathan D Moore, Lesley A Ward, Maxim B Freidin, Eric Lim, Manu Vatish, David R J Snead
    Histopathology.2014; 64(4): 547.     CrossRef
  • Neuroendocrine tumours—challenges in the diagnosis and classification of pulmonary neuroendocrine tumours
    M A den Bakker, F B J M Thunnissen
    Journal of Clinical Pathology.2013; 66(10): 862.     CrossRef
  • Morphologic Analysis of Pulmonary Neuroendocrine Tumors
    Seung Seok Lee, Myunghee Kang, Seung Yeon Ha, Jungsuk An, Mee Sook Roh, Chang Won Ha, Jungho Han
    Korean Journal of Pathology.2013; 47(1): 16.     CrossRef
  • Altered expression of microRNA miR-21, miR-155, and let-7a and their roles in pulmonary neuroendocrine tumors
    Hyoun Wook Lee, Eun Hee Lee, Seung Yeon Ha, Chang Hun Lee, Hee Kyung Chang, Sunhee Chang, Kun Young Kwon, Il Seon Hwang, Mee Sook Roh, Jeong Wook Seo
    Pathology International.2012; 62(9): 583.     CrossRef
Biologic Response to Carbonated Hydroxyapatite Associated with Orthopedic Device: Experimental Study in a Rabbit Model
Samira Jebahi, Mongi Saoudi, Riadh Badraoui, Tarek Rebai, Hassane Oudadesse, Zoubaier Ellouz, Hassib Keskese, Abdelfattah El Feki, Hafed El Feki
Korean J Pathol. 2012;46(1):48-54.   Published online February 23, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.1.48
  • 5,500 View
  • 40 Download
  • 9 Citations
AbstractAbstract PDF
Background

Carbonated hydroxyapatite (CHA) and related calcium phosphates have been studied for many years as implant materials due to their similarity with the mineral phase of bone. The main limitation of CHA ceramics as well as other bioactive materials is that they have poor mechanical proprieties. It is thought that the mechanical device can cause an increase in metabolic activity and bone healing. In this study we investigated the reactivity and tissue behaviour of implanted CHA biomaterial reinforced by mini external fixator.

Methods

The evaluation of biomaterial biocompatibility and osteogenesis was performed on a rabbit model over a period of 6 weeks by radiological, histological and scanning electron microscopy (SEM) coupled with energy dispersive X-ray SEM-energy-dispersive X-ray (EDX) analysis.

Results

While rabbits treated with CHA exhibited more bone formation, and fibrous tissue was observed when empty bone defects were observed. EDX analysis detected little calcium and phosphorus on the surface of the bone that was not implanted, while high content of calcium (62.7%) and phosphorus (38%) was found on the interface bone cement.

Conclusions

Bone repairing showed that the mini external fixator stimulated the ossification which was pushed when grafted by CHA. This effect may play an important role in the prevention of implant loosening.

Citations

Citations to this article as recorded by  
  • Improvement in bioactivity and corrosion resistance of Ti by hydroxyapatite deposition using ultrasonic mechanical coating and armoring
    Ming-Hong Lin, Yi-Cheng Chen, Chun-Chung Liao, Liang-Wei Lin, Chin-Fu Chen, Kuang-Kuo Wang, Shyi-Tien Chen, Yi-Huang Hsueh, Chien-Hui Wu, Shih-Fu Ou
    Ceramics International.2022; 48(4): 4999.     CrossRef
  • A review: In vivo studies of bioceramics as bone substitute materials
    Ali A. Al‐allaq, Jenan S. Kashan
    Nano Select.2022;[Epub]     CrossRef
  • Novel bioactive collagen-polyurethane-pectin scaffolds for potential application in bone regenerative medicine
    Myriam L. Guzmán-Chávez, Jesús A. Claudio-Rizo, Martín Caldera-Villalobos, Denis A. Cabrera-Munguía, Juan J. Becerra-Rodríguez, Nayeli Rodríguez-Fuentes
    Applied Surface Science Advances.2022; 11: 100317.     CrossRef
  • Chitosan-Based Gastric Dressing Materials Loaded with Pomegranate Peel as Bioactive Agents: Pharmacokinetics and Effects on Experimentally Induced Gastric Ulcers in Rabbits
    Samira Jebahi, Ghada Ben Salah, Soufien Jarray, Mounir Naffati, Mohammad Ayaz Ahmad, Faten Brahmi, Mohd Saeed, Arif J. Siddiqui, Khabir Abdelmajid, Riadh Badraoui
    Metabolites.2022; 12(12): 1158.     CrossRef
  • Is THP‐1 viability affected by the crystallinity of nanostructured carbonated hydroxyapatites?
    Renata Moraes Lira, Suelen Cristina Sartoretto, Carolina Silva Gouveia Pedrosa, Mônica Diuana Calasans‐Maia, Paulo Emílio Leite, José Mauro Granjeiro
    Journal of Biomedical Materials Research Part A.2021; 109(7): 1266.     CrossRef
  • Does the incorporation of zinc into calcium phosphate improve bone repair? A systematic review
    Rebecca Cruz, José Calasans-Maia, Suelen Sartoretto, Vittório Moraschini, Alexandre Malta Rossi, Rafael Seabra Louro, José Mauro Granjeiro, Monica Diuana Calasans-Maia
    Ceramics International.2018; 44(2): 1240.     CrossRef
  • Adsorption of nucleotides on biomimetic apatite: The case of adenosine 5′ monophosphate (AMP)
    K. Hammami, H. El Feki, O. Marsan, C. Drouet
    Applied Surface Science.2015; 353: 165.     CrossRef
  • Finite element analysis and cellular studies on advanced, controlled porous structures with subsurface continuity in bio-implantable titanium alloys
    P. Lambert, S. Ankem, Z. Wyatt, K. M. Ferlin, J. Fisher
    Journal of Biomedical Materials Research Part A.2014; 102(1): 225.     CrossRef
  • The impact of orthopedic device associated with carbonated hydroxyapatite on the oxidative balance: experimental study of bone healing rabbit model
    Samira Jebahi, Riadh Nsiri, Mohammed Boujbiha, Ezedine Bouroga, Tarek Rebai, Hassib Keskes, Abdelfattah El Feki, Hassane Oudadesse, Hafed El Feki
    European Journal of Orthopaedic Surgery & Traumatology.2013; 23(7): 759.     CrossRef
Detection of Survivin and COX-2 in Thyroid Carcinoma: Anaplastic Carcinoma Shows Overexpression of Nuclear Survivin and Low COX-2 Expression
Young A Kim, Meesoo Chang, Young Joo Park, Ji Eun Kim
Korean J Pathol. 2012;46(1):55-60.   Published online February 23, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.1.55
  • 7,168 View
  • 52 Download
  • 5 Citations
AbstractAbstract PDF
Background

Overexpression of survivin, a member of the inhibitors of apoptosis protein, has been reported in various carcinomas, and its interaction with cyclooxygenase 2 (COX-2) results in accelerated tumor progression. The purpose of this study is to investigate the immunohistochemical expression of survivin and COX-2 in benign and malignant thyroid tissues and to define its association with pathologic and clinical features.

Methods

We examined expression of survivin and COX-2 by immunohistochemistry in 334 benign and malignant thyroid tissues and evaluated their clinical significance.

Results

Expression of survivin showed an increase along the spectrum of thyroid carcinoma progression; rarely positive in adenomatous goiter, moderately positive in papillary carcinoma, and strongly positive in anaplastic carcinoma (AC). Papillary microcarcinoma revealed the highest COX-2 positivity and AC demonstrated the lowest positivity among thyroid cancers. Node negative carcinomas showed higher COX-2 expression than node positive tumors. Survivin expression did not correlate with COX-2.

Conclusions

Our findings suggest that survivin overexpression may be related to the pathogenesis of AC and can be a predictor of disease progression. COX-2 may be involved in the early phase of thyroid carcinoma.

Citations

Citations to this article as recorded by  
  • Survivin as a diagnostic and therapeutic marker for thyroid cancer
    Mohammad-Reza Mahmoudian-Sani, Arash Alghasi, Ali Saeedi-Boroujeni, Akram Jalali, Mohammad Jamshidi, Ali Khodadadi
    Pathology - Research and Practice.2019; 215(4): 619.     CrossRef
  • TFAP2B overexpression contributes to tumor growth and progression of thyroid cancer through the COX-2 signaling pathway
    Xiaoyan Fu, Huayong Zhang, Zhipeng Chen, Zhongyuan Yang, Dingbo Shi, Tianrun Liu, Weichao Chen, Fan Yao, Xuan Su, Wuguo Deng, Miao Chen, Ankui Yang
    Cell Death & Disease.2019;[Epub]     CrossRef
  • Expression of nm23-H1 and COX-2 in thyroid papillary carcinoma and microcarcinoma
    Marija Milkovic Perisa, Bozena Sarcevic, Koraljka Gall Troselj, Kresimir Grsic, Sanda Sitic, Sven Seiwerth
    Oncology Letters.2017; 13(5): 3547.     CrossRef
  • The Diagnostic Usefulness of HMGA2, Survivin, CEACAM6, and SFN/14-3-3 δ in Follicular Thyroid Carcinoma
    Min Hye Jang, Kyeong Cheon Jung, Hye Sook Min
    Journal of Pathology and Translational Medicine.2015; 49(2): 112.     CrossRef
  • Evaluation of survivin expression and its prognostic value in papillary thyroid carcinoma
    Sonja Selemetjev, Tijana Isic Dencic, Ilona Marecko, Jelena Jankovic, Ivan Paunovic, Svetlana Savin, Dubravka Cvejic
    Pathology - Research and Practice.2014; 210(1): 30.     CrossRef
Detection of BRAFV600E Mutations in Papillary Thyroid Carcinomas by Peptide Nucleic Acid Clamp Real-Time PCR: A Comparison with Direct Sequencing
Dongjun Jeong, Yujun Jeong, Sungche Lee, Hyeran Lee, Wanju Lee, Hyungjoo Kim, Doosan Park, Soyoung Park, Wenxia Mu, Hyun-Deuk Cho, Mee-Hye Oh, Sung Soo Lee, Seung-Ha Yang, Chang-Jin Kim
Korean J Pathol. 2012;46(1):61-67.   Published online February 23, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.1.61
  • 9,040 View
  • 58 Download
  • 17 Citations
AbstractAbstract PDF
Background

Papillary thyroid carcinoma (PTC) of the thyroid is the most common endocrine malignancy. High prevalence of an activating point mutation of BRAF gene, BRAFV600E, has been reported in PTC. We assessed the efficiency of peptide nucleic acid clamp real-time polymerase chain reaction (PNAcqPCR) for the detection of BRAFV600E mutation in PTC in comparison with direct sequencing (DS).

Methods

A total of 265 thyroid lesions including 200 PTCs, 5 follicular carcinomas, 60 benign lesions and 10 normal thyroid tissues were tested for BRAFV600E mutation by PNAcqPCR and DS.

Results

The sensitivity and accuracy of the PNAcqPCR method were both higher than those of DS for the detection of the BRAFV600E mutation. In clinical samples, 89% of PTCs harbored the BRAFV600E mutation, whereas 5 follicular carcinomas, 50 benign lesions and 10 normal thyroid tissues lacked the mutation. The mutation was associated with aggressive clinical behaviors as extrathyroid invasion (p=0.015), lymph node metastasis (p=0.002) and multiple tumor numbers (p=0.016) with statistical significance.

Conclusions

The PNAcqPCR method is efficiently applicable for the detection of the BRAFV600E mutation in PTCs in a clinical setting.

Citations

Citations to this article as recorded by  
  • TROP-2 and 5hmC expression in follicular-patterned thyroid neoplasm emphasizing tiny well-formed papillae
    Jae Yeon Seok, Xuemo Fan
    Annals of Diagnostic Pathology.2022; 57: 151903.     CrossRef
  • Null Association between BRAF V600E Mutation and Tumor Recurrence in Patients with Papillary Thyroid Microcarcinoma in South Korea
    Ji Yoon Kim, Kyoung Jin Kim, Jae Hyun Bae, Joo Hyung Kim, Nam Hoon Kim, Hee Young Kim, Hoon Yub Kim, Seung-Kuk Baek, Sin Gon Kim, Kwang Yoon Jung, Kyeong Jin Kim
    International Journal of Thyroidology.2021; 14(2): 135.     CrossRef
  • Evaluation of the expression levels of BRAFV600E mRNA in primary tumors of thyroid cancer using an ultrasensitive mutation assay
    Tien Viet Tran, Kien Xuan Dang, Quynh Huong Pham, Ung Dinh Nguyen, Nhung Thi Trang Trinh, Luong Van Hoang, Son Anh Ho, Ba Van Nguyen, Duc Trong Nguyen, Dung Tuan Trinh, Dung Ngoc Tran, Arto Orpana, Ulf-Håkan Stenman, Jakob Stenman, Tho Huu Ho
    BMC Cancer.2020;[Epub]     CrossRef
  • The Current State of Molecular Testing in the BRAF-Mutated Melanoma Landscape
    Irene Vanni, Enrica Teresa Tanda, Francesco Spagnolo, Virginia Andreotti, William Bruno, Paola Ghiorzo
    Frontiers in Molecular Biosciences.2020;[Epub]     CrossRef
  • Highly prevalent BRAF V600E and low-frequency TERT promoter mutations underlie papillary thyroid carcinoma in Koreans
    Sue Youn Kim, Taeeun Kim, Kwangsoon Kim, Ja Seong Bae, Jeong Soo Kim, Chan Kwon Jung
    Journal of Pathology and Translational Medicine.2020; 54(4): 310.     CrossRef
  • Molecular pathology of thyroid tumours of follicular cells: a review of genetic alterations and their clinicopathological relevance
    Giorgia Acquaviva, Michela Visani, Andrea Repaci, Kerry J Rhoden, Dario de Biase, Annalisa Pession, Tallini Giovanni
    Histopathology.2018; 72(1): 6.     CrossRef
  • Development of ultra-short PCR assay to reveal BRAF V600 mutation status in Thai colorectal cancer tissues
    Nunthawut Chat-Uthai, Pichpisith Vejvisithsakul, Sutthirat Udommethaporn, Puttarakun Meesiri, Chetiya Danthanawanit, Yannawan Wongchai, Chinachote Teerapakpinyo, Shanop Shuangshoti, Naravat Poungvarin, John Souglakos
    PLOS ONE.2018; 13(6): e0198795.     CrossRef
  • T-blocker: a simple and robust probe-free quantitative PCR assay to detect somatic mutations down to 0.1% frequency
    Hanyoup Kim, Aaron E Ruby, Harini G Shandilya, Arvind K Virmani, Nandita Rahman, Christina M Strange, Jarkko Huuskonen
    BioTechniques.2018; 65(4): 205.     CrossRef
  • The usefulness of a novel fully automated PCR-based Idylla test for detection of the BRAF V600E mutation in thyroid tissue: comparison with PNA-clamping PCR, real-time PCR and pyrosequencing
    Min-Kyung Yeo, Min-Kyu Jung, Su-Yel Lee, Yong-Moon Lee, Gang Min Hur, Jin-Man Kim
    Journal of Clinical Pathology.2017; 70(3): 260.     CrossRef
  • KRAS mutation analysis of washing fluid from endoscopic ultrasound-guided fine needle aspiration improves cytologic diagnosis of pancreatic ductal adenocarcinoma
    Joo Kyung Park, Yoon Jung Lee, Jong Kyun Lee, Kyu Taek Lee, Yoon-La Choi, Kwang Hyuck Lee
    Oncotarget.2017; 8(2): 3519.     CrossRef
  • Application of Peptide Nucleic Acid-based Assays Toward Detection of Somatic Mosaicism
    Christopher S Hong, Chunzhang Yang, Zhengping Zhuang
    Molecular Therapy - Nucleic Acids.2016; 5: e314.     CrossRef
  • Prediction Table and Nomogram as Tools for Diagnosis of Papillary Thyroid Carcinoma
    Seo Ki Kim, Jun Ho Lee, Jung-Woo Woo, Inhye Park, Jun-Ho Choe, Jung-Han Kim, Jee Soo Kim
    Medicine.2015; 94(21): e760.     CrossRef
  • The association between BRAF V600E mutation and pathological features in PTC
    Xin Liu, Kangkang Yan, Xuejun Lin, Longyu Zhao, Wenxiu An, Chunpeng Wang, Xiaodong Liu
    European Archives of Oto-Rhino-Laryngology.2014; 271(11): 3041.     CrossRef
  • Recurrent Thyroid Papillary Carcinoma in Children Under Ten Years Old: Report of Two Cases and Literature Review
    Byeong-Joo Noh, Ji-Youn Sung, Youn-Wha Kim, Yong-Koo Park
    Korean Journal of Pathology.2014; 48(4): 297.     CrossRef
  • KRASMutation Detection in Non-small Cell Lung Cancer Using a Peptide Nucleic Acid-Mediated Polymerase Chain Reaction Clamping Method and Comparative Validation with Next-Generation Sequencing
    Boram Lee, Boin Lee, Gangmin Han, Mi Jung Kwon, Joungho Han, Yoon-La Choi
    Korean Journal of Pathology.2014; 48(2): 100.     CrossRef
  • VE1 immunohistochemistry in pituitary adenomas is not associated with BRAF V600E mutation
    Jan Sperveslage, Midea Gierke, David Capper, Jürgen Honegger, Bence Sipos, Rudi Beschorner, Jens Schittenhelm
    Acta Neuropathologica.2013; 125(6): 911.     CrossRef
  • BRAF Mutations in Iranian Patients with Papillary Thyroid Carcinoma
    Nastran Ranjbari, Sara Almasi, Javad Mohammadi-asl, Fakher Rahim
    Asian Pacific Journal of Cancer Prevention.2013; 14(4): 2521.     CrossRef
Evaluation of Urine Cytology in Urothelial Carcinoma Patients: A Comparison of CellprepPlus® Liquid-Based Cytology and Conventional Smear
Seung-Myoung Son, Ji Hae Koo, Song-Yi Choi, Ho-Chang Lee, Yong-Moon Lee, Hyung Geun Song, Hae-Kyung Hwang, Hye-Suk Han, Seok-Joong Yun, Wun-Jae Kim, Eun-Joong Kim, Ok-Jun Lee
Korean J Pathol. 2012;46(1):68-74.   Published online February 23, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.1.68
  • 8,692 View
  • 71 Download
  • 10 Citations
AbstractAbstract PDF
Background

Urine cytology is an important test in the screening of urothlelial neoplasms. The conventional smear (CS) method of testing urine samples has a low sensitivity, approximately 50% result accuracy for detecting urothelial carcinomas, while liquid-based cytology (LBC) has much improved diagnostic accuracy, sensitivity, and specificity. The aim of this study was to compare the morphologic features and diagnostic efficacy of CellprepPlus® LBC with those of CS for urine cytology.

Methods

A total of 713 cases of urine specimens collected from November 2009 to September 2010 were included. All specimens were divided equally for the preparation of CellprepPlus® LBC and CS for each case.

Results

CellprepPlus® revealed more cellularity, a cleaner background and better cytomorphologic features, but it showed a less intact architectural pattern compared to that of CS. Of the 88 histologically confirmed cases, the diagnostic sensitivity for CellprepPlus® was 50% and higher than the 37.5% for CS. The specificity of both preparations was 100%.

Conclusions

The CellprepPlus® showed an improved quality of slides and provided better diagnostic accuracy, thus CellprepPlus® could be a first-line screening tool in urinary tract cytology.

Citations

Citations to this article as recorded by  
  • Deep Learning-Based Screening of Urothelial Carcinoma in Whole Slide Images of Liquid-Based Cytology Urine Specimens
    Masayuki Tsuneki, Makoto Abe, Fahdi Kanavati
    Cancers.2022; 15(1): 226.     CrossRef
  • Diagnostic efficacy of smear plus liquid-based cytology for EUS-FNA of solid pancreatic lesions
    Masahiro Itonaga, Shin-Ichi Murata, Keiichi Hatamaru, Takashi Tamura, Junya Nuta, Yuki Kawaji, Takao Maekita, Mikitaka Iguchi, Jun Kato, Fumiyoshi Kojima, Hiroki Yamaue, Manabu Kawai, Ken-Ichi Okada, Seiko Hirono, Toshio Shimokawa, Kensuke Tanioka, Masayu
    Medicine.2019; 98(19): e15575.     CrossRef
  • Evaluation and application of Cellprep for cervical cytology
    Rinko OZEKI, Keiichi IWAYA, Yuko UMAYAHARA, Yuka MORITA, Mie ARAI, Yukari TAKASUGI, Ryoko KIKUCHI, Kiyohiko MIYAKE, Atsuhiko SAKAMOTO, Masaru SAKAMOTO
    The Journal of the Japanese Society of Clinical Cytology.2018; 57(3): 159.     CrossRef
  • Quantitative Proteomic Analysis Identifies AHNAK (Neuroblast Differentiation-associated Protein AHNAK) as a Novel Candidate Biomarker for Bladder Urothelial Carcinoma Diagnosis by Liquid-based Cytology
    Hyebin Lee, Kwangsoo Kim, Jongmin Woo, Joonho Park, Hyeyoon Kim, Kyung Eun Lee, Hyeyeon Kim, Youngsoo Kim, Kyung Chul Moon, Ji Young Kim, In Ae Park, Bo Bae Shim, Ji Hye Moon, Dohyun Han, Han Suk Ryu
    Molecular & Cellular Proteomics.2018; 17(9): 1788.     CrossRef
  • Reliability of Estrogen Receptor and Human Epidermal Growth Factor Receptor 2 Expression on Breast Cancer Cells Stored in Cellprep® Vials
    Ayumi Ryu, Jyun-ichi Ashimura, Takahiro Nakayama, Yasuhiro Tamaki, Shin-ichi Nakatsuka, Yasuhiko Tomita
    Acta Cytologica.2018; 62(5-6): 360.     CrossRef
  • Morphologic Analysis of Cytomegalovirus Infected Cells in Bronchial Washing Cytology: Comparison of Liquid-Based Preparation and Conventional Smear
    Jae Yeon Seok, Jungsuk An, Seung Yeon Ha, Dong Hae Chung, Sangho Lee, Hyunchul Kim
    Journal of Pathology and Translational Medicine.2016; 50(2): 147.     CrossRef
  • Romanowsky staining using liquid-based cytology: A pilot study using Cytolyt®/HESPANDER®processing solution for ThinPrep®preparations
    Yuichi Kinoshita, Takashi Yuri, Katsuhiko Yoshizawa, Kosho Takasu, Yuko Emoto, Airo Tsubura, Nobuaki Shikata
    Diagnostic Cytopathology.2015; 43(12): 960.     CrossRef
  • Diagnostic Value of Liquid-Based Cytology in Urothelial Carcinoma Diagnosis: A Systematic Review and Meta-Analysis
    You Luo, Dong-Li She, Hu Xiong, Li Yang, Sheng-Jun Fu, Francisco X. Real
    PLOS ONE.2015; 10(8): e0134940.     CrossRef
  • Comparison of diagnostic accuracy between CellprepPlus® and ThinPrep® liquid-based preparations in effusion cytology
    Yong-Moon Lee, Ji-Yong Hwang, Seung-Myoung Son, Song-Yi Choi, Ho-Chang Lee, Eun-Joong Kim, Hye-Suk Han, Jin young An, Joung-Ho Han, Ok-Jun Lee
    Diagnostic Cytopathology.2014; 42(5): 384.     CrossRef
  • Diagnostic Efficacy of Cell Block Immunohistochemistry, Smear Cytology, and Liquid-Based Cytology in Endoscopic Ultrasound-Guided Fine-Needle Aspiration of Pancreatic Lesions: A Single-Institution Experience
    Shan-yu Qin, You Zhou, Ping Li, Hai-xing Jiang, Robert L. Schmidt
    PLoS ONE.2014; 9(9): e108762.     CrossRef
Case Reports
A Soft Tissue Perineurioma and a Hybrid Tumor of Perineurioma and Schwannoma
Ji Young Park, Nam Jo Park, Sang Pyo Kim, Kun Young Kwon, Sang Sook Lee
Korean J Pathol. 2012;46(1):75-78.   Published online February 23, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.1.75
  • 6,255 View
  • 54 Download
  • 13 Citations
AbstractAbstract PDF

Perineuriomas are composed of differentiated perineurial cells. Perineuriomas have been recently recognized by the immunoreactivity for epithelial membrane antigen (EMA). Microscopically, perineuriomas show proliferation of spindle cells with wavy nuclei and delicate elongated bipolar cytoplasmic processes. The tumor cells are usually negative for the S-100 protein. Ultrastructurally, perineurial cells reveal slender, nontapered processes containing pinocytic vesicles and discontinuous basal lamina. Interestingly, hybrid tumors of benign peripheral nerve sheath tumor (PNST) have been recently reported by using immunohistochemical and ultrastructural investigations. Herein, we report a case of soft tissue perineurioma arising in the skin of a 56-year-old female; another case of a hybrid tumor of perineurioma and schwannoma in the posterior mediastinum occurred in a 53-year-old male, which is the first case of the hybrid PNST tumor reported in Korea.

Citations

Citations to this article as recorded by  
  • Hybrid tumors with perineurioma components: a systematic review of the literature and illustrative case
    Karina A. Lenartowicz, Dileep D. Monie, Kimberly K. Amrami, Christopher J. Klein, Caterina Giannini, Robert J. Spinner
    Acta Neurochirurgica.2022;[Epub]     CrossRef
  • Hybrid Schwannoma/Perineurioma: Morphologic Variations and Genetic Profiles
    Takanori Hirose, Anna Kobayashi, Sumihito Nobusawa, Naoe Jimbo
    Applied Immunohistochemistry & Molecular Morphology.2021; 29(6): 433.     CrossRef
  • Mesenchymal Tumors of the Mediastinum: An Update on Diagnostic Approach
    Joon Hyuk Choi, Jae Y. Ro
    Advances in Anatomic Pathology.2021; 28(5): 351.     CrossRef
  • Neurogenic Tumors of the Mediastinum
    Erika F. Rodriguez, Robert Jones, Daniel Miller, Fausto J. Rodriguez
    Seminars in Diagnostic Pathology.2020; 37(4): 179.     CrossRef
  • A Rare Perineurioma/Granular Cell Tumor Hybrid Peripheral Nerve Sheath Tumor
    Koorosh Haghayeghi, Gladys Telang, Sonja Chen, Jack Bevivino, Shamlal Mangray, Yiang Hui, Leslie Robinson-Bostom
    The American Journal of Dermatopathology.2020; 42(10): 762.     CrossRef
  • Hibrid periferik sinir kılıfı tümörleri
    Emine Kilic Bagir, Arbil Acikalin, Gulfiliz Gonlusen, Suzan Zorludemir, Mehmet Ali Deveci
    Cukurova Medical Journal.2019; 44(3): 1.     CrossRef
  • Primary intraosseous hybrid epithelioid schwannoma/perineurioma in the proximal tibia: a case report of benign hybrid neoplasm with local hypercellularity
    Yuejiao Lang, Dawei Liu, Pei Xiang, Jilin Wang, Yang Li
    Diagnostic Pathology.2019;[Epub]     CrossRef
  • Hybrid peripheral nerve sheath tumors: report of five cases and detailed review of literature
    Nasir Ud Din, Zubair Ahmad, Jamshid Abdul-Ghafar, Rashida Ahmed
    BMC Cancer.2017;[Epub]     CrossRef
  • Primary intraosseous hybrid nerve sheath tumor of femur: A hitherto undescribed occurrence in bone with secondary aneurysmal bone cyst formation resulting in pathological fracture
    Louis Tsun Cheung Chow
    Pathology - Research and Practice.2015; 211(5): 409.     CrossRef
  • Mesenchymal tumours of the mediastinum—part II
    Michael A. den Bakker, Alexander Marx, Kiyoshi Mukai, Philipp Ströbel
    Virchows Archiv.2015; 467(5): 501.     CrossRef
  • Primary pleural hybrid cellular schwannoma/perineurioma: A case report
    Danny Soria-Céspedes, Carlos Robles-Vidal, Arturo Gómez-González, Rosalinda Peñaloza-Ramírez, Carlos Ortiz-Hidalgo
    Respiratory Investigation.2014; 52(4): 269.     CrossRef
  • Hybrid peripheral nerve sheath tumour with intermingled perineuriomatous and schwannomatous areas reflected in skin ultrasonography image
    H. Saeki, K. Ito, Y. Nobeyama, T. Ishiji, M. Fukunaga, H. Nakagawa
    Clinical and Experimental Dermatology.2014; 39(6): 747.     CrossRef
  • Périneuriome extraneural des tissus mous localisé au nez
    A. Zaouak, R. Benmously, M. Belhadj Salah, W. Koubaa, A. Debbiche, I. Mokhtar
    Annales de Dermatologie et de Vénéréologie.2013; 140(8-9): 540.     CrossRef
Hyaline Vascular Castleman Disease Involving Renal Parenchyma and a Lymph Node: A Case Report
Ji Hyun Kwon, Soo Kee Min, Mi Kyung Shin, Yong Seong Lee, Young-Goo Lee, Young Hyeh Ko
Korean J Pathol. 2012;46(1):79-82.   Published online February 23, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.1.79
  • 6,680 View
  • 48 Download
  • 3 Citations
AbstractAbstract PDF

Castleman disease is a rare lymphoproliferative lesion that is predominantly found in the mediastinum. Retroperitoneal and pararenal localizations are very rare. We describe a 36-year-old man with a hyaline vascular type of Castleman disease involving renal parenchyma and a paraaortic lymph node. Most reported renal Castleman disease was plasma cell type with systemic symptoms. Herein, we report the first Korean case of the hyaline vascular type of Castleman disease involving the renal parenchyma and the paraaortic lymph node simultaneously.

Citations

Citations to this article as recorded by  
  • Castleman Disease of the Kidney in Computed Tomography Urography
    Kai Wang, Fengjuan Xing, Heng Ma, Wenjuan Li
    Current Medical Imaging Formerly Current Medical Imaging Reviews.2022; 18(1): 74.     CrossRef
  • Primary hyaline vascular Castleman disease of the kidney: case report and literature review
    Yunzhu Li, Haixia Zhao, Bingyin Su, Chan Yang, Shurong Li, Wanlei Fu
    Diagnostic Pathology.2019;[Epub]     CrossRef
  • Castleman’s Disease of the Kidney Mimicking Renal Cell Carcinoma on FDG PET/CT
    Yang Wang, Aisheng Dong, Bo Yang, Jianping Lu
    Clinical Nuclear Medicine.2018; 43(5): e160.     CrossRef
Urachal Mucinous Tumor of Uncertain Malignant Potential: A Case Report
Jung-Woo Choi, Ju-Han Lee, Young-Sik Kim
Korean J Pathol. 2012;46(1):83-86.   Published online February 23, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.1.83
  • 7,790 View
  • 44 Download
  • 7 Citations
AbstractAbstract PDF

Urachal mucinous tumor of uncertain malignant potential is very rare and is characterized by a multilocular cyst showing the proliferation of atypical mucin-secreting cells without stromal invasion. As in ovarian and appendiceal borderline tumors, it represents a transitional stage of mucinous carcinogenesis in the urachus. In addition, this tumor may recur locally and develop into pseudomyxoma peritonei. Due to its scarcity and diagnostic challenges, we report a mucinous tumor of uncertain malignant potential arising in the urachus.

Citations

Citations to this article as recorded by  
  • Mucinous Cystadenoma of the Urachus and Review of Current Classification of Urachal Mucinous Cystic Neoplasms
    Diping Wang, Norbert Sule
    Archives of Pathology & Laboratory Medicine.2019; 143(2): 258.     CrossRef
  • Urachal Mucinous Cystic Tumor of Low Malignant Potential with Concurrent Sigmoid Colon Adenocarcinoma
    Kelly Brennan, Paul Johnson, Heather Curtis, Thomas Arnason
    Case Reports in Gastrointestinal Medicine.2019; 2019: 1.     CrossRef
  • Pseudomyxoma Peritonei Arising from Mucinous Cystadenoma of the Urachus with Postoperative Disease-Free Survival over 15 Years
    Tomoki Kobayashi, Shinichi Mizuno, Hideki Matsuba, Min Kanamori, Toshio Tamauchi, Makoto Urano
    The Japanese Journal of Gastroenterological Surgery.2019; 52(6): 307.     CrossRef
  • Urachal borderline mucinous cystadenoma
    Jingjun Wu, Ailian Liu, Anliang Chen, Pengxin Zhang
    Medicine.2017; 96(47): e8740.     CrossRef
  • Incidental Finding of a Rare Urachal Pathology: Urachal Mucinous Cystic Tumour of Low Malignant Potential
    Luke L. Wang, Heath Liddell, Sharman Tan Tanny, Briony Norris, Sree Appu, David Pan
    Case Reports in Urology.2016; 2016: 1.     CrossRef
  • A Case of Borderline Mucinous Cystadenoma Thought to be of Urachal Origin
    Kiichiro YAGUCHI, Yoshihito GOMYO, Hiroyasu SAITO, Tatsuo IKENO, Hiromi SAKAGUCHI, Hideo MIYAMOTO
    Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2014; 75(5): 1418.     CrossRef
  • An unexpected mass of the urachus: a case report
    Monica C. Pasternak, Jonathan D. Black, Natalia Buza, Masoud Azodi, Aileen Gariepy
    American Journal of Obstetrics and Gynecology.2014; 211(4): e1.     CrossRef
Mimicry of Minute Pulmonary Meningothelial-like Nodules to Metastatic Deposits in a Patient with Infiltrating Lobular Carcinoma: A Case Report and Review of the Literature
Hala Kfoury, Maria A. Arafah, Maha M. Arafah, Sami Alnassar, Waseem Hajjar
Korean J Pathol. 2012;46(1):87-91.   Published online February 23, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.1.87
  • 7,085 View
  • 50 Download
  • 4 Citations
AbstractAbstract PDF

Minute pulmonary meningothelial-like nodules (MPMNs) are incidentally found lesions in lung resection specimens and autopsies. MPMNs have been associated with neoplastic and non-neoplastic pulmonary conditions and occasionally with extrapulmonary diseases. We report a case of a female patient presenting with invasive lobular carcinoma of the breast and MPMNs, masquerading as metastatic deposits. We describe the morphological, immunohistochemical and ultrastructural features of MPMNs and emphasize the importance of their recognition for proper staging and treatment of patients. To our knowledge, this is the first case in the English literature describing this coexistence.

Citations

Citations to this article as recorded by  
  • Benign disease prone to be misdiagnosed as malignant pulmonary nodules: Minute meningothelioid nodules
    Xiao‐Xiao Peng, Li‐Xu Yan, Chao Liu, Si‐Yun Wang, Wen‐Feng Li, Xing Gao, Xue‐Wu Wei, Qing Zhou
    Thoracic Cancer.2019; 10(5): 1182.     CrossRef
  • Atypical finding of meningothelial-like inclusions in cervical lymph nodes
    Rebecca Donkin, Andrew Dettrick, Penelope Wyche, Sarah Grigg
    Pathology.2018; 50(7): 785.     CrossRef
  • Minute Pulmonary Meningothelial-Like Nodules Simulating Hematogenous Lung Metastasis: A Case Report
    Sang Kook Lee, Gi Jeong Kim, Young Jae Kim, Ah Young Leem, Eu Dong Hwang, Se Kyu Kim, Joon Chang, Young Ae Kang, Song Yee Kim
    Tuberculosis and Respiratory Diseases.2013; 75(2): 67.     CrossRef
  • Diffuse Pulmonary Meningotheliomatosis Diagnosed by Transbronchial Lung Biopsy
    Roberto Bernabeu Mora, Juan Miguel Sánchez Nieto, Chunshao Hu, Eduardo Alcaraz Mateos, Alberto Giménez Bascuñana, Manuel Rodríguez Rodríguez
    Respiration.2013; 86(2): 145.     CrossRef

JPTM : Journal of Pathology and Translational Medicine