Preoperative radiotherapy may improve the resectability and subsequent local control of rectal cancers. However, the extent of radiation induced regression in these tumours varies widely between individuals. To date no reliable predictive marker of radiation sensitivity in rectal cancer has been identified. At the cellular level, radiation injury initiates a complex molecular network of DNA damage response (DDR) pathways that leads to cell cycle arrest, attempts at re-constituting the damaged DNA and should this fail, then apoptosis. This review presents the details which suggest the roles of DNA mismatch repair proteins, the lack of which define a distinct subset of colorectal cancers with microsatellite instability (MSI), in the DDR pathways. Hence routine assessment of the MSI status in rectal cancers may potentially serve as a predictor of radiotherapy response, thereby improving patient stratification in the administration of this otherwise toxic treatment.

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• Comparison of the Diagnostic Efficacy of Ultrasound‐Guided Core Needle Biopsy With 18‐ Versus 20‐Gauge Needles for Thyroid Nodules
  Hye Shin Ahn, Mirinae Seo, Su Min Ha, Hee Sung Kim
  Journal of Ultrasound in Medicine.2018; 37(11): 2565.     CrossRef
• Subclassification of Bethesda Atypical and Follicular Neoplasm Categories According to Nuclear and Architectural Atypia Improves Discrimination of Thyroid Malignancy Risk
  Joel Xue Yi Lim, Min En Nga, Dedrick Kok Hong Chan, Wee Boon Tan, Rajeev Parameswaran, Kee Yuan Ngiam
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• The expression profile of integrin receptors and osteopontin in thyroid malignancies varies depending on the tumor progression rate and presence of BRAF V600E mutation
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• The Usefulness of Immunocytochemistry of CD56 in Determining Malignancy from Indeterminate Thyroid Fine-Needle Aspiration Cytology
  Hyunseo Cha, Ju Yeon Pyo, Soon Won Hong
  Journal of Pathology and Translational Medicine.2018; 52(6): 404.     CrossRef
• Core Needle Biopsy of the Thyroid: 2016 Consensus Statement and Recommendations from Korean Society of Thyroid Radiology
  Dong Gyu Na, Jung Hwan Baek, So Lyung Jung, Ji-hoon Kim, Jin Yong Sung, Kyu Sun Kim, Jeong Hyun Lee, Jung Hee Shin, Yoon Jung Choi, Eun Ju Ha, Hyun Kyung Lim, Soo Jin Kim, Soo Yeon Hahn, Kwang Hwi Lee, Young Jun Choi, Inyoung Youn, Young Joong Kim, Hye Sh
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• Radiofrequency ablation of small follicular neoplasms: initial clinical outcomes
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• A meta‐analytic review of the Bethesda System for Reporting Thyroid Cytopathology: Has the rate of malignancy in indeterminate lesions been underestimated?
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• Impact of NRAS Mutations on the Diagnosis of Follicular Neoplasm of the Thyroid
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• Diagnosis of Thyroid Follicular Neoplasm: Fine-Needle Aspiration Versus Core-Needle Biopsy
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Epithelioid trophoblastic tumor is an unusual type of trophoblastic tumor. Here we report on the clinicopathologic and immunohistochemical features of three cases of epithelioid trophoblastic tumor. All three patients were of reproductive age and presented with vaginal bleeding and mild elevation of human chorionic gonadotropin (hCG). All patients underwent a hysterectomy. The tumors consisted of epithelioid intermediate trophoblastic cells that were mononucleated and eosinophilic, or showed clear cytoplasm on microscopic examination. One case presented with a focal choriocarcinoma component. Immunohistochemically, the tumors displayed diffuse positivity for cytokeratin 18, E-cadherin, epidermal growth factor receptor, and p53 and focal positivity for p63 and hCG. However, expression of α-inhibin and placental alkaline phosphatase was almost negative. Tests for human placental lactogen and epithelial membrane antigen were also negative in all cases.

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• Epithelioid Trophoblastic Tumour: A Case with Genetic Linkage to a Child Born over Seventeen Years Prior, Successfully Treated with Surgery and Pembrolizumab
  David Pisani, Jean Calleja-Agius, Riccardo Di Fiore, John J. O’Leary, James P. Beirne, Sharon A. O’Toole, Ana Felix, Ian Said-Huntingford
  Current Oncology.2021; 28(6): 5346.     CrossRef
• Epithelioid Trophoblastic Tumor
  Stephanie M. McGregor, Larissa V. Furtado, Anthony G. Montag, Rebecca Brooks, Ricardo R. Lastra
  International Journal of Gynecological Pathology.2020; 39(1): 8.     CrossRef
• Epithelioid trophoblastic tumor in a postmenopausal woman: A case report and review of the literature in the postmenopausal group
  Seyran Yigit, Eylul Gun, Bulent Yilmaz, Zafer Kolsuz
  Indian Journal of Pathology and Microbiology.2020; 63(5): 98.     CrossRef
• Double trouble: Extrauterine epithelioid trophoblastic tumor with uterine choriocarcinoma - An autopsy report
  Kusum Jashnani, Alshifa Yagana, Niraj Mahajan
  Indian Journal of Cancer.2020;[Epub]     CrossRef
• Epithelioid trophoblastic tumor coexisting with choriocarcinoma around an abdominal wall cesarean scar: a case report and review of the literature
  Chunfeng Yang, Jianqi Li, Yuanyuan Zhang, Hanzhen Xiong, Xiujie Sheng
  Journal of Medical Case Reports.2020;[Epub]     CrossRef
• Placental site trophoblastic tumor and epithelioid trophoblastic tumor: Clinical and pathological features, prognostic variables and treatment strategy
  Angiolo Gadducci, Silvestro Carinelli, Maria Elena Guerrieri, Giovanni Damiano Aletti
  Gynecologic Oncology.2019; 153(3): 684.     CrossRef
• Diagnosis and Management of Mixed Gestational Trophoblastic Neoplasia: A Study of 16 Cases and a Review of the Literature
  Yujia Kong, Guangshi Tao, Liju Zong, Junjun Yang, Xirun Wan, Wenze Wang, Yang Xiang
  Frontiers in Oncology.2019;[Epub]     CrossRef
• A Case Series of Five Patients With Pure or Mixed Gestational Epithelioid Trophoblastic Tumors and a Literature Review on Mixed Tumors
  Ka Yu Tse, Keith Wan Hang Chiu, Karen Kar Loen Chan, Mandy Man Yee Chu, Siew Fei Ngu, Annie Nga Yin Cheung, Hextan Yuen Sheung Ngan, Philip Pun Ching Ip
  American Journal of Clinical Pathology.2018; 150(4): 318.     CrossRef
• MR Imaging of Uterine Epithelioid Trophoblastic Tumor: A Case Report
  Sakiko KAGEYAMA, Masafumi KANOTO, Yukio SUGAI, Takeshi SUTO, Satoru NAGASE, Mitsumasa OSAKABE, Takaaki HOSOYA
  Magnetic Resonance in Medical Sciences.2016; 15(4): 411.     CrossRef
• Pharmacotherapy of placental site and epithelioid trophoblastic tumours
  Fiona Taylor, Barry W Hancock
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• A Well-Circumscribed Border with Peripheral Doppler Signal in Sonographic Image Distinguishes Epithelioid Trophoblastic Tumor from Other Gestational Trophoblastic Neoplasms
  Jiale Qin, Weiwen Ying, Xiaodong Cheng, Xiaodong Wu, Bingjian Lu, Yun Liang, Xinyu Wang, Xiaoyun Wan, Xing Xie, Weiguo Lu, Hai-Yan Lin
  PLoS ONE.2014; 9(11): e112618.     CrossRef

Benign triton tumors (BTT) are very rare lesions composed of mature skeletal muscle and neural tissue. We report a case of a 14-year-old boy who presented with asymptomatic swelling of the chin over an 18-month duration which increased gradually to involve the left side of the lower lip. Clinically, a diagnosis of neurofibroma was made. Excisional biopsy confirmed the diagnosis of a BTT. Having an affinity for large nerve trunks like the brachial and sciatic, these tumors rarely occur in the head and neck region. When they do, they may involve the large central cranial nerve trunk and present as intracranial masses or involve the smaller peripheral nerve twigs and present as asymptomatic skin nodules, of which only four cases involving peripheral nerves are reported in the English literature. Here, we report the fifth documented case of a BTT involving the mental branch of the trigeminal nerve. A brief review of the literature is also provided.

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• Update on MR Imaging of Soft Tissue Tumors of Head and Neck
  Justin D. Rodriguez, A. Morgan Selleck, Ahmed Abdel Khalek Abdel Razek, Benjamin Y. Huang
  Magnetic Resonance Imaging Clinics of North America.2022; 30(1): 151.     CrossRef
• Pediatric benign triton tumor of trigeminal nerve: a case report and literature review
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  Child's Nervous System.2022; 38(11): 2055.     CrossRef
• Rhabdomyomatous mesenchymal hamartoma presenting as a chin nodule in a 15‐year‐old male
  Lisa M. Marinelli, Wendi E. Wohltmann, Kevin D. Myers, Geoffrey T. Sasaki
  Journal of Cutaneous Pathology.2021; 48(2): 322.     CrossRef
• Pediatric Benign Tumors With a Skeletal Muscle Component: Myogenin Expression, Diagnostic Pitfalls, and New Molecular Insights
  Lara Berklite, John Ozolek, Larry Wang, Luisa Santoro, Vittoria Donofrio, Alessandra Stracuzzi, Ivy John, Rita Alaggio
  Pediatric and Developmental Pathology.2021; 24(3): 213.     CrossRef
• Incidental Hamartoma in an elderly patient: a case report
  Tae-Sung Joo, Hyejee Kim, In-Ki Park, Jae-Ho Shin
  BMC Ophthalmology.2020;[Epub]     CrossRef
• Peripheral Nerve Sheath Tumors of Head and Neck: Imaging-Based Review of World Health Organization Classification
  Ahmed Abdel Khalek Abdel Razek, Omneya A. Gamaleldin, Nermeen A. Elsebaie
  Journal of Computer Assisted Tomography.2020; 44(6): 928.     CrossRef
• Benign peripheral nerve tumors
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  Injury.2019; 50: S77.     CrossRef
• Tumor de tritón benigno: reporte de un caso en órbita
  Tatiana Urrea Victoria, Luis Alberto Ruíz Robles, Ana María Vanegas Monroy, Humberto Quintana Muñoz
  Universitas Médica.2017;[Epub]     CrossRef
• Benign Triton Tumor: Multidisciplinary Approach to Diagnosis and Treatment
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• Ectomesenchymoma with Embryonal Rhabdomyosarcoma and Ganglioneuroma, Arising in Association with Benign Triton Tumor of the Tongue
  Katherine A. VandenHeuvel, David F. Carpentieri, Jie Chen, Kar-Ming Fung, David M. Parham
  Pediatric and Developmental Pathology.2014; 17(3): 226.     CrossRef
• Adulthood Benign Triton Tumor Developed in the Orbit
  Dong Hyeon Bae, Choong Hyun Kim, Jin Hwan Cheong, Jae Min Kim
  Journal of Korean Neurosurgical Society.2014; 56(2): 146.     CrossRef

A case of peripheral primitive neuroectodermal tumor of the small bowel mesentery with osseous component is reported. A 23-year-old man was admitted to our hospital because of acute severe abdominal pain. Abdominal computed tomography revealed a large solid and cystic, oval shaped mass, measuring 11.0×6.0 cm in the pelvic cavity. Histologically the resected lesion consisted of sheets of undifferentiated small round cells forming Homer-Wright rosettes and perivascular pseudorosettes, and showed areas of osteoid and bone formation. Immunohistochemical studies revealed that tumor cells expressed positivity against CD99 (MIC2), CD57, neuron-specific enolase, and vimentin. Fluorescence in situ hybridization study revealed Ewing sarcoma breakpoint region 1 (EWSR1) gene rearrangement on chromosome 22q12. To the authors' knowledge this is the first documentation of a peripheral neuroectodermal tumor with osteoid and bone formation of the small bowel mesentery.

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• Primary Ewing’s sarcoma in a small intestine – a case report and review of the literature
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  LIBO PENG, LIMIN YANG, NAN WU, BO WU
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  Alia Zehani, Ines Chelly, Beya Chelly, Jean-Michel Coindre, Slim Haouet, Nidhameddine Kchir
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• Actinomyeces Cerebral Abscess Masquerading as Tuberculosis: Delayed Presentation following Head Trauma and Scalp Infection
  Manish Kumar, Ankur Bajaj, Manjul Tripathi, BishanD Radotra, ManojK Tewari, ChiragK Ahuja
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• Diagnostic Performance of Core Needle Biopsy for Characterizing Thyroidectomy Bed Lesions
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