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Volume 47(1); February 2013
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Review
Radiotherapy Response in Microsatellite Instability Related Rectal Cancer
Joo-Shik Shin, Thein Ga Tut, Tao Yang, C. Soon Lee
Korean J Pathol. 2013;47(1):1-8.   Published online February 25, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.1.1
  • 8,893 View
  • 73 Download
  • 26 Citations
AbstractAbstract PDF

Preoperative radiotherapy may improve the resectability and subsequent local control of rectal cancers. However, the extent of radiation induced regression in these tumours varies widely between individuals. To date no reliable predictive marker of radiation sensitivity in rectal cancer has been identified. At the cellular level, radiation injury initiates a complex molecular network of DNA damage response (DDR) pathways that leads to cell cycle arrest, attempts at re-constituting the damaged DNA and should this fail, then apoptosis. This review presents the details which suggest the roles of DNA mismatch repair proteins, the lack of which define a distinct subset of colorectal cancers with microsatellite instability (MSI), in the DDR pathways. Hence routine assessment of the MSI status in rectal cancers may potentially serve as a predictor of radiotherapy response, thereby improving patient stratification in the administration of this otherwise toxic treatment.

Citations

Citations to this article as recorded by  
  • Potential risks associated with the use of ionizing radiation for imaging and treatment of colorectal cancer in Lynch syndrome patients
    Mingzhu Sun, Jayne Moquet, Michele Ellender, Simon Bouffler, Christophe Badie, Rachel Baldwin-Cleland, Kevin Monahan, Andrew Latchford, David Lloyd, Susan Clark, Nicola A. Anyamene, Elizabeth Ainsbury, David Burling
    Familial Cancer.2023; 22(1): 61.     CrossRef
  • Rectal Cancer in Patients with Hereditary Nonpolyposis Colorectal Cancer Compared with Sporadic Cases: Response to Neoadjuvant Chemoradiation and Local Recurrence
    Khaled M Madbouly, Sameh Hany Emile, Yasmine Amr Issa
    Journal of the American College of Surgeons.2022; 234(5): 793.     CrossRef
  • Not All Patients With Locally Advanced Rectal Cancer Benefit From Neoadjuvant Therapy
    Carolyn Chang, Jonathan T. Bliggenstorfer, Jessie Liu, Jennifer Shearer, Paul Dreher, Katherine Bingmer, Sharon L. Stein, Emily Steinhagen
    The American Surgeon.2022; : 000313482211094.     CrossRef
  • Molecular Recognition and Quantification of MLH1, MSH2, MSH6, PMS2, and KRAS in Biological Samples
    Raluca-Ioana Stefan-van Staden, Ruxandra-Maria Ilie-Mihai, Maria Coros, Stela Pruneanu
    ECS Sensors Plus.2022; 1(3): 031606.     CrossRef
  • Magnetic resonance imaging downstaging, pathological response, and microsatellite instability status in patients with signet-ring cell carcinoma rectum undergoing preoperative long-course chemoradiation
    B Rajkrishna, Saikat Das, Dipti Masih, Tharani Putta, Rajat Raghunath, ThomasSamuel Ram
    Current Medical Issues.2022; 20(3): 154.     CrossRef
  • Biomarkers and cell-based models to predict the outcome of neoadjuvant therapy for rectal cancer patients
    Aylin Alkan, Tobias Hofving, Eva Angenete, Ulf Yrlid
    Biomarker Research.2021;[Epub]     CrossRef
  • Microsatellite Instability (MSI) as an Independent Predictor of Pathologic Complete Response (PCR) in Locally Advanced Rectal Cancer
    Shaakir Hasan, Paul Renz, Rodney E. Wegner, Gene Finley, Moses Raj, Dulabh Monga, James McCormick, Alexander Kirichenko
    Annals of Surgery.2020; 271(4): 716.     CrossRef
  • Delivery of Personalized Care for Locally Advanced Rectal Cancer: Incorporating Pathological, Molecular Genetic, and Immunological Biomarkers Into the Multimodal Paradigm
    Éanna J. Ryan, Ben Creavin, Kieran Sheahan
    Frontiers in Oncology.2020;[Epub]     CrossRef
  • Association of mismatch repair status with survival and response to neoadjuvant chemo(radio)therapy in rectal cancer
    Shu-Biao Ye, Yi-Kan Cheng, Lin Zhang, Yi-Feng Zou, Ping Chen, Yan-Hong Deng, Yan Huang, Jian-Hong Peng, Xiao-Jian Wu, Ping Lan
    npj Precision Oncology.2020;[Epub]     CrossRef
  • Implication of expression of MMR proteins and clinicopathological characteristics in gastric cancer
    Renu Verma, Puja Sakhuja, Ritu Srivastava, Prakash Chand Sharma
    Asia-Pacific Journal of Oncology.2020; : 1.     CrossRef
  • Mismatch Repair–Deficient Rectal Cancer and Resistance to Neoadjuvant Chemotherapy
    Andrea Cercek, Gustavo Dos Santos Fernandes, Campbell S. Roxburgh, Karuna Ganesh, Shu Ng, Francisco Sanchez-Vega, Rona Yaeger, Neil H. Segal, Diane L. Reidy-Lagunes, Anna M. Varghese, Arnold Markowitz, Chao Wu, Bryan Szeglin, Charles-Etienne Gabriel Sauvé
    Clinical Cancer Research.2020; 26(13): 3271.     CrossRef
  • The Mismatch Repair System (MMR) in Head and Neck Carcinogenesis and Its Role in Modulating the Response to Immunotherapy: A Critical Review
    Maria Cilona, Luca Giovanni Locatello, Luca Novelli, Oreste Gallo
    Cancers.2020; 12(10): 3006.     CrossRef
  • Genetics of rectal cancer and novel therapies: primer for radiologists
    Sebastian Mondaca, Rona Yaeger
    Abdominal Radiology.2019; 44(11): 3743.     CrossRef
  • Mismatch repair deficiency as a predictive marker for response to adjuvant radiotherapy in endometrial cancer
    Casper Reijnen, Heidi V.N. Küsters-Vandevelde, Clemens F. Prinsen, Leon F.A.G. Massuger, Marc P.M.L. Snijders, Stefan Kommoss, Sara Y. Brucker, Janice S. Kwon, Jessica N. McAlpine, Johanna M.A. Pijnenborg
    Gynecologic Oncology.2019; 154(1): 124.     CrossRef
  • Mismatch Repair System Deficiency Is Associated With Response to Neoadjuvant Chemoradiation in Locally Advanced Rectal Cancer
    Nicolas Meillan, Dewi Vernerey, Jérémie H. Lefèvre, Gilles Manceau, Magali Svrcek, Jeremy Augustin, Jean-François Fléjou, Olivier Lascols, Jean-Marc Simon, Romain Cohen, Philippe Maingon, Jean-Baptiste Bachet, Florence Huguet
    International Journal of Radiation Oncology*Biology*Physics.2019; 105(4): 824.     CrossRef
  • Promoter methylation and expression of DNA repair genes MGMT and ERCC1 in tissue and blood of rectal cancer patients
    Sally M. Shalaby, Amal S. El-Shal, Lobna A. Abdelaziz, Eman Abd-Elbary, Mostafa M. Khairy
    Gene.2018; 644: 66.     CrossRef
  • RBBP 6 increases radioresistance and serves as a therapeutic target for preoperative radiotherapy in colorectal cancer
    Chao Xiao, Yupeng Wang, Miao Zheng, Jian Chen, Guohe Song, Zhijie Zhou, Chongzhi Zhou, Xing Sun, Lin Zhong, Erxun Ding, Yi Zhang, Liu Yang, Gang Wu, Shifeng Xu, Hong Zhang, Xiaoliang Wang
    Cancer Science.2018; 109(4): 1075.     CrossRef
  • Baseline MAPK signaling activity confers intrinsic radioresistance to KRAS-mutant colorectal carcinoma cells by rapid upregulation of heterogeneous nuclear ribonucleoprotein K (hnRNP K)
    Stefan Eder, Annette Arndt, Andreas Lamkowski, Wassiliki Daskalaki, Alexis Rump, Markus Priller, Felicitas Genze, Eva Wardelmann, Matthias Port, Konrad Steinestel
    Cancer Letters.2017; 385: 160.     CrossRef
  • The current value of determining the mismatch repair status of colorectal cancer: A rationale for routine testing
    E. Ryan, K. Sheahan, B. Creavin, H.M. Mohan, D.C. Winter
    Critical Reviews in Oncology/Hematology.2017; 116: 38.     CrossRef
  • Exploration of Mutation and DNA Methylation of Polo-Like Kinase 1 (PLK1) in Colorectal Cancer
    Wayne Ng, Joo-Shik Shin, Bin Wang, Cheok Soon Lee
    Open Journal of Pathology.2017; 07(03): 45.     CrossRef
  • Expression of Mismatch Repair Proteins in Early and Advanced Gastric Cancer in Poland
    Katarzyna Karpińska-Kaczmarczyk, Magdalena Lewandowska, Małgorzata Ławniczak, Andrzej Białek, Elżbieta Urasińska
    Medical Science Monitor.2016; 22: 2886.     CrossRef
  • DNA Mismatch Repair Deficiency in Rectal Cancer: Benchmarking Its Impact on Prognosis, Neoadjuvant Response Prediction, and Clinical Cancer Genetics
    Nicole de Rosa, Miguel A. Rodriguez-Bigas, George J. Chang, Jula Veerapong, Ester Borras, Sunil Krishnan, Brian Bednarski, Craig A. Messick, John M. Skibber, Barry W. Feig, Patrick M. Lynch, Eduardo Vilar, Y. Nancy You
    Journal of Clinical Oncology.2016; 34(25): 3039.     CrossRef
  • miRNA-148b regulates radioresistance in non-small lung cancer cells via regulation of MutL homologue 1
    Guangsheng Zhai, Gaozhong Li, Bo Xu, Tongfu Jia, Yinping Sun, Jianbo Zheng, Jianbin Li
    Bioscience Reports.2016;[Epub]     CrossRef
  • Predictive and prognostic biomarkers for neoadjuvant chemoradiotherapy in locally advanced rectal cancer
    S.H. Lim, W. Chua, C. Henderson, W. Ng, J.-S. Shin, L. Chantrill, R. Asghari, C.S. Lee, K.J. Spring, P. de Souza
    Critical Reviews in Oncology/Hematology.2015; 96(1): 67.     CrossRef
  • Potential of DNA methylation in rectal cancer as diagnostic and prognostic biomarkers
    Ruth Exner, Walter Pulverer, Martina Diem, Lisa Spaller, Laura Woltering, Martin Schreiber, Brigitte Wolf, Markus Sonntagbauer, Fabian Schröder, Judith Stift, Fritz Wrba, Michael Bergmann, Andreas Weinhäusel, Gerda Egger
    British Journal of Cancer.2015; 113(7): 1035.     CrossRef
  • Study of Liver Transplant Rejection in Alcoholism-Induced Cirrhosis
    J. Tinoco González, C. Bernal Bellido, G. Jimenez Riera, V. Camacho Marente, L.M. Marín Gómez, G. Suárez Artacho, J.M. Álamo Martínez, J. Serrano Díez-Canedo, R.J. Padillo Ruíz, M.A. Gómez Bravo
    Transplantation Proceedings.2013; 45(10): 3650.     CrossRef
Original Articles
CHD1L Is a Marker for Poor Prognosis of Hepatocellular Carcinoma after Surgical Resection
Jiyeon Hyeon, Soomin Ahn, Cheol-Keun Park
Korean J Pathol. 2013;47(1):9-15.   Published online February 25, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.1.9
  • 6,474 View
  • 51 Download
  • 19 Citations
AbstractAbstract PDF
Background

The gene for chromodomain helicase/ATPase DNA binding protein 1-like (CHD1L) was recently identified as a target oncogene within the 1q21 amplicon, which occurs in 46% to 86% of primary hepatocellular carcinoma (HCC) cases. However, the prognostic significance of CHD1L in HCC remains uncertain. In this study, we investigated the roles of CHD1L in the prognosis of HCC.

Methods

We investigated the expressions of CHD1L in tumor tissue microarrays of 281 primary HCC patients who underwent surgical resection using immunohistochemistry. Prognostic factors of HCC were examined by univariate and multivariate analyses. The median follow-up period was 75.6 months.

Results

CHD1L expression was observed in 48 of the 281 HCCs (17.1%). CHD1L expression was associated with a younger age (p=0.033), higher Edmondson grade (p=0.019), microvascular invasion (p<0.001), major portal vein invasion (p=0.037), higher American Joint Committee on Cancer T stage (p=0.001), lower albumin level (p=0.047), and higher α-fetoprotein level (p=0.002). Multivariate analyses revealed that CHD1L expression (p=0.027), Edmondson grade III (p=0.034), and higher Barcelona Clinic Liver Cancer stage (p<0.001) were independent predictors of shorter disease-free survival.

Conclusions

CHD1L expression might be a prognostic marker of shorter disease-free survival in HCC patients after surgical resection.

Citations

Citations to this article as recorded by  
  • Design, Synthesis, and Biological Evaluation of the First Inhibitors of Oncogenic CHD1L
    Brett J. Prigaro, Hector Esquer, Qiong Zhou, Laura A. Pike, Paul Awolade, Xin-He Lai, Adedoyin D. Abraham, Joshua M. Abbott, Brock Matter, Uday B. Kompella, Wells A. Messersmith, Daniel L. Gustafson, Daniel V. LaBarbera
    Journal of Medicinal Chemistry.2022; 65(5): 3943.     CrossRef
  • Diversity roles of CHD1L in normal cell function and tumorigenesis
    Xifeng Xiong, Xudong Lai, Aiguo Li, Zhihe Liu, Ningfang Ma
    Biomarker Research.2021;[Epub]     CrossRef
  • Elevated serum alpha-fetoprotein levels are associated with poor prognosis of hepatocellular carcinoma after surgical resection: A systematic review and meta-analysis
    Hong-Lin Chen, Yu-Hua Chen, Lin Du, Yi-Ping Song, Bin Zhu
    Arab Journal of Gastroenterology.2021; 22(1): 12.     CrossRef
  • Genome-wide scanning for CHD1L gene in papillary thyroid carcinoma complicated with type 2 diabetes mellitus
    Y. Y. Kang, J. J. Li, J. X. Sun, J. X. Wei, C. Ding, C. L. Shi, G. Wu, K. Li, Y. F. Ma, Y. Sun, H. Qiao
    Clinical and Translational Oncology.2021; 23(12): 2536.     CrossRef
  • The high expression of CHD1L and its clinical significance in human solid tumors
    Long Zhang, Yufen Jiang, Panpan Jiao, Xiaohong Deng, Yuancai Xie
    Medicine.2021; 100(10): e24851.     CrossRef
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    Pathology & Oncology Research.2020; 26(4): 2587.     CrossRef
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    Joshua M. Abbott, Qiong Zhou, Hector Esquer, Laura Pike, Travis P. Broneske, Sébastien Rinaldetti, Adedoyin D. Abraham, Dominique A. Ramirez, Paul J. Lunghofer, Todd M. Pitts, Daniel P. Regan, Aik Choon Tan, Daniel L. Gustafson, Wells A. Messersmith, Dani
    Molecular Cancer Therapeutics.2020; 19(8): 1598.     CrossRef
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    Wanwei Liu, Jiwei Xu, Caiyun Zhang
    Medicine.2018; 97(29): e11522.     CrossRef
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    Chuan Liu, Xiaowei Fu, Zhiwei Zhong, Jing Zhang, Haiyan Mou, Qiong Wu, Tianle Sheng, Bo Huang, Yeqing Zou
    Digestive Diseases and Sciences.2017; 62(9): 2376.     CrossRef
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    Ze-Han Liu, Qi Zhang, Yi-Jie Ding, Ying-Hui Ren, Hui-Peng Yang, Qing Xi, Ying-Nan Cheng, Guo-Lin Miao, Hong-Kun Liu, Cai-Xia Li, Wen-Qiang Yan, Yan Li, Zhenyi Xue, Lijuan Zhang, Xin-Ye Li, Chen-Long Zhao, Yurong Da, Xian-Zhong Wu, Jun-Qiang Chen, Rongxin
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Morphologic Analysis of Pulmonary Neuroendocrine Tumors
Seung Seok Lee, Myunghee Kang, Seung Yeon Ha, Jungsuk An, Mee Sook Roh, Chang Won Ha, Jungho Han
Korean J Pathol. 2013;47(1):16-20.   Published online February 25, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.1.16
  • 5,319 View
  • 34 Download
  • 2 Citations
AbstractAbstract PDF
Background

Few studies on how to diagnose pulmonary neuroendocrine tumors through morphometric analysis have been reported. In this study, we measured and analyzed the characteristic parameters of pulmonary neuroendocrine tumors using an image analyzer to aid in diagnosis.

Methods

Sixteen cases of typical carcinoid tumor, 5 cases of atypical carcinoid tumor, 15 cases of small cell carcinoma, and 51 cases of large cell neuroendocrine carcinoma were analyzed. Using an image analyzer, we measured the nuclear area, perimeter, and the major and minor axes.

Results

The mean nuclear area was 0.318±0.101 µm2 in typical carcinoid tumors, 0.326±0.119 µm2 in atypical carcinoid tumors, 0.314±0.107 µm2 in small cell carcinomas, and 0.446±0.145 µm2 in large cell neuroendocrine carcinomas. The mean nuclear circumference was 2.268±0.600 µm in typical carcinoid tumors, 2.408±0.680 µm in atypical carcinoid tumors, 2.158±0.438 µm in small cell carcinomas, and 3.247±1.276 µm in large cell neuroendocrine carcinomas. All parameters were useful in distinguishing large cell neuroendocrine carcinoma from other tumors (p=0.001) and in particular, nuclear circumference was the most effective (p=0.001).

Conclusions

Pulmonary neuroendocrine tumors showed nuclear morphology differences by subtype. Therefore, evaluation of quantitative nuclear parameters improves the accuracy and reliability of diagnosis.

Citations

Citations to this article as recorded by  
  • Clinical Significance of Persistent Tumor in Bone Marrow during Treatment of High-risk Neuroblastoma
    Young Bae Choi, Go Eun Bae, Na Hee Lee, Jung-Sun Kim, Soo Hyun Lee, Keon Hee Yoo, Ki Woong Sung, Hong Hoe Koo
    Journal of Korean Medical Science.2015; 30(8): 1062.     CrossRef
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    Go Eun Bae, Yeon-Lim Suh, Ki Woong Sung, Jung-Sun Kim
    Korean Journal of Pathology.2013; 47(5): 433.     CrossRef
Histopathological Causes of Late Liver Allograft Dysfunction: Analysis at a Single Institution
Eun Shin, Ji Hoon Kim, Eunsil Yu
Korean J Pathol. 2013;47(1):21-27.   Published online February 25, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.1.21
  • 6,102 View
  • 53 Download
  • 3 Citations
AbstractAbstract PDF
Background

We summarize our experience in the pathological diagnosis of late complications of liver transplantation (LT) to better understand the causes of late allograft dysfunction in a population mostly composed of patients with hepatitis B virus (HBV) infection.

Methods

We reviewed 361 post-transplant liver biopsies from 174 patients who underwent LT and first presented with liver function abnormalities 3 months post-procedure. The underlying diseases included HBV-associated liver disease (77%), toxic or alcoholic liver disease (10.3%), hepatitis C virus (HCV)-associated liver disease (8.6%), primary biliary cirrhosis (1.2%), primary sclerosing cholangitis (1.2%), and metabolic disease (1.7%).

Results

The three most common late complications were acute rejection (32.5%), recurrent disease (19.1%), and biliary complication (17.1%). Patients who underwent LT for HBV infection or for drug- or alcohol-related liver disease had a lower incidence of recurring disease than those who underwent transplantation for HCV infection. During post-transplantation months 3-12, acute rejection was the most common cause of allograft dysfunction and recurring disease was the leading cause for allograft dysfunction (p=0.039). The two primary causes of late allograft dysfunction have overlapping histological features, although acute rejection more frequently showed bile duct damage and vascular endothelialitis than recurring HBV infection, and recurring HBV infection had more frequent lobular activity and piecemeal necrosis.

Conclusions

The causes of late liver allograft dysfunction are closely associated with the original liver diseases and the period after LT. Careful attention is required for differential diagnosis between acute rejection and recurrent HBV.

Citations

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Microsatellite Instability Status in Gastric Cancer: A Reappraisal of Its Clinical Significance and Relationship with Mucin Phenotypes
Joo-Yeun Kim, Na Ri Shin, Ahrong Kim, Hyun-Jeong Lee, Won-young Park, Jee-Yeon Kim, Chang-Hun Lee, Gi-Young Huh, Do Youn Park
Korean J Pathol. 2013;47(1):28-35.   Published online February 25, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.1.28
  • 7,716 View
  • 87 Download
  • 54 Citations
AbstractAbstract PDF
Background

Gastric cancers with microsatellite instabilities (MSI) have been reported to be associated with favorable prognosis. However, the significance of the effect of MSI on the clinicopathological features, as well as its association with mucin phenotype, remains unclear.

Methods

MSI status was assessed in 414 cases of gastric cancer using polymerase chain reaction analysis of five microsatellite loci, as recommended by National Cancer Institution criteria. The expression of mucins (MUC5AC, MUC6, MUC2, and CD10) was assessed.

Results

Out of 414 total cases of gastric cancer, 380 (91.7%), 11 (2.7%), and 23 (5.6%) were microsatellite stable (MSS), low-level MSI (MSI-L), and high-level MSI (MSI-H), respectively. Compared to MSS/MSI-L, MSI-H gastric cancers were associated with older age (p=0.010), tumor size (p=0.014), excavated gross (p=0.042), intestinal type (p=0.028), aggressive behaviors (increase of T stage [p=0.009]), perineural invasion [p=0.022], and lymphovascular emboli [p=0.027]). MSI-H gastric cancers were associated with tumor necrosis (p=0.041), tumor-infiltrating lymphocytes (≥2/high power field, p<0.001), expanding growth patterns (p=0.038), gastric predominant mucin phenotypes (p=0.028), and MUC6 expression (p=0.016). Tumor necrosis (≥10% of mass, p=0.031), tumor-infiltrating lymphocytes (p<0.001), intestinal type (p=0.014), and gastric mucin phenotypes (p=0.020) could represent independent features associated with MSI-H gastric cancers. MSI-H intestinal type gastric cancers had a tendency for poor prognosis in univariate analysis (p=0.054) but no association in Cox multivariate analysis (p=0.197).

Conclusions

Our data suggest that MSI-H gastric cancers exhibit distinct aggressive biologic behaviors and a gastric mucin phenotype. This contradicts previous reports that describe MSI-H gastric cancer as being associated with favorable prognosis.

Citations

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Finding and Characterizing Mammary Analogue Secretory Carcinoma of the Salivary Gland
Min Jung Jung, Joon Seon Song, Sang Yoon Kim, Soon Yuhl Nam, Jong-Lyel Roh, Seung-Ho Choi, Sung-Bae Kim, Kyung-Ja Cho
Korean J Pathol. 2013;47(1):36-43.   Published online February 25, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.1.36
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AbstractAbstract PDF
Background

A new tumor entity of the salivary glands, mammary analogue secretory carcinoma (MASC) with ETV6-NTRK3 translocation, has recently been proposed. MASC was originally diagnosed as adenocarcinoma, not otherwise specified (ANOS), or acinic cell carcinoma (AciCC) by the current World Health Organization classification. We aimed to identify MASC cases by molecular tests, and to characterize their clinical, histological, and immunohistochemical features.

Methods

Thirty cases of MASC candidates were selected after review of 196 salivary gland tumors, and subjected to break-apart ETV6 fluorescence in situ hybridization (FISH), and immunohistochemical study for S100 protein, gross cystic disease fluid protein 15, DOG1, estrogen receptor, and progesterone receptor.

Results

Valid FISH results were obtained in 23 cases, and 13 positive cases were retrieved. MASCs were histologically varied, and the most frequent features observed in 10 cases were low-grade papillary/cystic/glandular patterns, intraluminal secretory materials, ovoid/wrinkled nuclei, and relatively abundant granular eosinophilic cytoplasms, corresponding to papillary-cystic or follicular types of AciCC. All cases showed diffuse immunopositivity for S100 protein. Three cases developed recurrences, but all patients remained alive.

Conclusions

MASC could be a molecularly well-defined salivary gland neoplasm, encompassing some portions of AciCC and ANOS, but its histological spectrum and clinical implication require further investigation.

Citations

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Alteration of the E-Cadherin/β-Catenin Complex Is an Independent Poor Prognostic Factor in Lung Adenocarcinoma
Hyojin Kim, Seol Bong Yoo, Pingli Sun, Yan Jin, Sanghoon Jheon, Choon Taek Lee, Jin-Haeng Chung
Korean J Pathol. 2013;47(1):44-51.   Published online February 25, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.1.44
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AbstractAbstract PDF
Background

Epithelial-mesenchymal transition (EMT) is an important step in the invasion and progression of cancer and in the development of chemoresistance by cancer cells.

Methods

To address the clinical significance of the EMT pathway in lung adenocarcinoma and the association of the pathway with histological subtype, we examined 193 surgically resected lung adenocarcinoma samples for the expression of representative EMT-related proteins (E-cadherin, β-catenin, and vimentin) by immunohistochemistry. Histological subtypes were classified according to the 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification. The results for EMT-related protein expression were analyzed for correlation with clinicopathological features and with survival.

Results

The loss of E-cadherin expression and aberrant β-catenin expression were significantly associated with larger tumor size, pleural invasion, lymphatic/vascular invasion, and advanced pathological stage (p<0.05). The alteration of the E-cadherin/β-catenin complex was least frequently observed in the lepidic-predominant group, but these associations were not statistically significant. In the multivariate analysis, altered E-cadherin/β-catenin complex expression was found to be an independent poor prognostic factor (p=0.017; hazard ratio, 1.926; 95% confidence interval, 1.119 to 3.314).

Conclusions

The alteration of the expression of the E-cadherin/β-catenin complex was associated with aggressive tumor behavior in lung adenocarcinoma.

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Comparison of Direct Sequencing, PNA Clamping-Real Time Polymerase Chain Reaction, and Pyrosequencing Methods for the Detection of EGFR Mutations in Non-small Cell Lung Carcinoma and the Correlation with Clinical Responses to EGFR Tyrosin
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DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.1.52
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AbstractAbstract PDF
Background

The aims of this study were to evaluate the abilities of direct sequencing (DS), peptide nucleic acid (PNA) clamping, and pyrosequencing methods to detect epidermal growth factor receptor (EGFR) mutations in formalin-fixed paraffin-embedded (FFPE) non-small cell lung carcinoma (NSCLC) samples and to correlate EGFR mutational status as determined by each method with the clinical response to EGFR tyrosine kinase inhibitors (TKIs).

Methods

Sixty-one NSCLC patients treated with EGFR TKIs were identified to investigate somatic mutations in the EGFR gene (exons 18-21).

Results

Mutations in the EGFR gene were detected in 38 of the 61 patients (62%) by DS, 35 (57%) by PNA clamping and 37 (61%) by pyrosequencing. A total of 44 mutations (72%) were found by at least one of the three methods, and the concordances among the results were relatively high (82-85%; kappa coefficient, 0.713 to 0.736). There were 15 discordant cases (25%) among the three different methods.

Conclusions

All three EGFR mutation tests had good concordance rates (over 82%) for FFPE samples. These results suggest that if the DNA quality and enrichment of tumor cells are assured, then DS, PNA clamping, and pyrosequencing are appropriate methods for the detection of EGFR mutations.

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    Seong-Hoon Yoon, Yoo-Duk Choi, In-Jae Oh, Kyu-Sik Kim, Hayoung Choi, Jinsun Chang, Hong-Joon Shin, Cheol-Kyu Park, Young-Chul Kim
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    Sang Hwa Lee, Wan Seop Kim, Yoo Duk Choi, Jeong Wook Seo, Joung Ho Han, Mi Jin Kim, Lucia Kim, Geon Kook Lee, Chang Hun Lee, Mee Hye Oh, Gou Young Kim, Sun Hee Sung, Kyo Young Lee, Sun Hee Chang, Mee Sook Rho, Han Kyeom Kim, Soon Hee Jung, Se Jin Jang
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    An Na Seo, Tae-In Park, Yan Jin, Ping-Li Sun, Hyojin Kim, Hyun Chang, Jin-Haeng Chung
    Lung Cancer.2014; 83(3): 316.     CrossRef
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    Tae-Jung Kim, Chan Kwon Park, Chang Dong Yeo, Kihoon Park, Chin Kook Rhee, Jusang Kim, Seung Joon Kim, Sang Haak Lee, Kyo-Young Lee, Hyoung-Kyu Yoon
    Journal of Surgical Oncology.2014; 110(3): 245.     CrossRef
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    Sung-Jun Ko, Yeon Joo Lee, Jong Sun Park, Young-Jae Cho, Ho Il Yoon, Jin-Haeng Chung, Tae Jung Kim, Kyung Won Lee, Kwhanmien Kim, Sanghoon Jheon, Hyojin Kim, Jae Ho Lee, Choon-Taek Lee
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    Ping-Li Sun, Ji Eun Kim, Seol Bong Yoo, Hyojin Kim, Yan Jin, Sanghoon Jheon, Kwhanmien Kim, Choon Taek Lee, Jin-Haeng Chung
    Annals of Surgical Oncology.2014; 21(S4): 610.     CrossRef
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    Marcin Nicoś, Tomasz Powrózek, Paweł Krawczyk, Bożena Jarosz, Beata Pająk, Marek Sawicki, Krzysztof Kucharczyk, Tomasz Trojanowski, Janusz Milanowski
    Medical Oncology.2014;[Epub]     CrossRef
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    A N Seo, J M Yang, H Kim, S Jheon, K Kim, C T Lee, Y Jin, S Yun, J-H Chung, J H Paik
    British Journal of Cancer.2014; 110(11): 2688.     CrossRef
  • KRASMutation Detection in Non-small Cell Lung Cancer Using a Peptide Nucleic Acid-Mediated Polymerase Chain Reaction Clamping Method and Comparative Validation with Next-Generation Sequencing
    Boram Lee, Boin Lee, Gangmin Han, Mi Jung Kwon, Joungho Han, Yoon-La Choi
    Korean Journal of Pathology.2014; 48(2): 100.     CrossRef
  • Guideline Recommendations forEGFRMutation Testing in Lung Cancer: Proposal of the Korean Cardiopulmonary Pathology Study Group
    Hyo Sup Shim, Jin-Haeng Chung, Lucia Kim, Sunhee Chang, Wan-Seop Kim, Geon Kook Lee, Soon-Hee Jung, Se Jin Jang
    Korean Journal of Pathology.2013; 47(2): 100.     CrossRef
  • Immunohistochemical Classification of Primary and Secondary Glioblastomas
    Kyu Sang Lee, Gheeyoung Choe, Kyung Han Nam, An Na Seo, Sumi Yun, Kyung Ju Kim, Hwa Jin Cho, Sung Hye Park
    Korean Journal of Pathology.2013; 47(6): 541.     CrossRef
Fine Needle Aspiration Cytology of Thyroid Follicular Neoplasm: Cytohistologic Correlation and Accuracy
Changyoung Yoo, Hyun Joo Choi, Soyoung Im, Ji Han Jung, Kiouk Min, Chang Suk Kang, Young-Jin Suh
Korean J Pathol. 2013;47(1):61-66.   Published online February 25, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.1.61
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AbstractAbstract PDF
Background

This study evaluated the accuracy of fine needle aspiration cytology (FNAC) in cases of follicular neoplasm (FN) on the basis of histologic diagnosis, and reviewed the cytologic findings of FN according to the FNAC.

Methods

Among the 66 cases diagnosed with thyroid FN by FNAC during the 7-year period from 2003 to 2009, 36 cases that had undergone thyroid surgery were available for review. Cytologic diagnosis was compared with the histologic diagnosis of each case.

Results

Among the 36 cases with a cytologic diagnosis of thyroid FN, histologic diagnosis was as follows: 20 follicular adenomas (55.6%), 3 Hurthle cell adenomas (8.3%), 2 follicular carcinomas (5.6%), 8 nodular goiters (22.2%), 2 papillary carcinomas (5.6%), and 1 Hashimoto's thyroiditis (2.8%), resulting in a diagnostic accuracy of FNAC for thyroid FN of 69.5%.

Conclusions

This study shows that FNAC for thyroid FN is a useful primary screening method because when FN is diagnosed by FNAC, the rate of FN histologic diagnosis is relatively high, however, adequate sampling and experience is a prerequisite for this procedure.

Citations

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    Hye Shin Ahn, Hee Sung Kim, Min Ji Hong, Paula Soares
    PLOS ONE.2022; 17(7): e0271437.     CrossRef
  • 2019 Practice guidelines for thyroid core needle biopsy: a report of the Clinical Practice Guidelines Development Committee of the Korean Thyroid Association
    Chan Kwon Jung, Jung Hwan Baek, Dong Gyu Na, Young Lyun Oh, Ka Hee Yi, Ho-Cheol Kang
    Journal of Pathology and Translational Medicine.2020; 54(1): 64.     CrossRef
  • Prevalence and Predictors of Malignancy in Contralateral Thyroid Lobe in Patients Undergoing Completion Thyroidectomy
    Pradipta Kumar Parida, Siddhartha Pradhan, Chapity Preetam, Pradeep Pradhan, Dillip Kumar Samal, Saurav Sarkar
    Indian Journal of Otolaryngology and Head & Neck Surgery.2020;[Epub]     CrossRef
  • Preoperative diagnostic categories of fine needle aspiration cytology for histologically proven thyroid follicular adenoma and carcinoma, and Hurthle cell adenoma and carcinoma: Analysis of cause of under- or misdiagnoses
    Hee Young Na, Jae Hoon Moon, June Young Choi, Hyeong Won Yu, Woo-Jin Jeong, Yeo Koon Kim, Ji-Young Choe, So Yeon Park, Paula Soares
    PLOS ONE.2020; 15(11): e0241597.     CrossRef
  • Core needle biopsy of thyroid nodules: outcomes and safety from a large single-center single-operator study
    Jooae Choe, Jung Hwan Baek, Hye Sun Park, Young Jun Choi, Jeong Hyun Lee
    Acta Radiologica.2018; 59(8): 924.     CrossRef
  • Cytological Features That Differentiate Follicular Neoplasm from Mimicking Lesions
    Kanghee Han, Hwa-Jeong Ha, Joon Seog Kong, Jung-Soon Kim, Jae Kyung Myung, Jae Soo Koh, Sunhoo Park, Myung-Soon Shin, Woo-Tack Song, Hye Sil Seol, Seung-Sook Lee
    Journal of Pathology and Translational Medicine.2018; 52(2): 110.     CrossRef
  • Comparison of the Diagnostic Efficacy of Ultrasound-Guided Core Needle Biopsy With 18- Versus 20-Gauge Needles for Thyroid Nodules
    Hye Shin Ahn, Mirinae Seo, Su Min Ha, Hee Sung Kim
    Journal of Ultrasound in Medicine.2018; 37(11): 2565.     CrossRef
  • Subclassification of Bethesda Atypical and Follicular Neoplasm Categories According to Nuclear and Architectural Atypia Improves Discrimination of Thyroid Malignancy Risk
    Joel Xue Yi Lim, Min En Nga, Dedrick Kok Hong Chan, Wee Boon Tan, Rajeev Parameswaran, Kee Yuan Ngiam
    Thyroid.2018; 28(4): 511.     CrossRef
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    Galina Chernaya, Nina Mikhno, Tatiana Khabalova, Svetlana Svyatchenko, Lyudmila Mostovich, Sergey Shevchenko, Lyudmila Gulyaeva
    Surgical Oncology.2018; 27(4): 702.     CrossRef
  • The Usefulness of Immunocytochemistry of CD56 in Determining Malignancy from Indeterminate Thyroid Fine-Needle Aspiration Cytology
    Hyunseo Cha, Ju Yeon Pyo, Soon Won Hong
    Journal of Pathology and Translational Medicine.2018; 52(6): 404.     CrossRef
  • Core Needle Biopsy of the Thyroid: 2016 Consensus Statement and Recommendations from Korean Society of Thyroid Radiology
    Dong Gyu Na, Jung Hwan Baek, So Lyung Jung, Ji-hoon Kim, Jin Yong Sung, Kyu Sun Kim, Jeong Hyun Lee, Jung Hee Shin, Yoon Jung Choi, Eun Ju Ha, Hyun Kyung Lim, Soo Jin Kim, Soo Yeon Hahn, Kwang Hwi Lee, Young Jun Choi, Inyoung Youn, Young Joong Kim, Hye Sh
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  • Radiofrequency ablation of small follicular neoplasms: initial clinical outcomes
    Su Min Ha, Jin Yong Sung, Jung Hwan Baek, Dong Gyu Na, Ji-hoon Kim, Hyunju Yoo, Ducky Lee, Dong Whan Choi
    International Journal of Hyperthermia.2017; : 1.     CrossRef
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Case Studies
Epithelioid Trophoblastic Tumor: Clinicopathologic and Immunohistochemical Analysis of Three Cases
Woo Jung Sung, Hyeong Chan Shin, Min-Kyung Kim, Mi Jin Kim
Korean J Pathol. 2013;47(1):67-73.   Published online February 25, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.1.67
  • 8,024 View
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  • 11 Citations
AbstractAbstract PDF

Epithelioid trophoblastic tumor is an unusual type of trophoblastic tumor. Here we report on the clinicopathologic and immunohistochemical features of three cases of epithelioid trophoblastic tumor. All three patients were of reproductive age and presented with vaginal bleeding and mild elevation of human chorionic gonadotropin (hCG). All patients underwent a hysterectomy. The tumors consisted of epithelioid intermediate trophoblastic cells that were mononucleated and eosinophilic, or showed clear cytoplasm on microscopic examination. One case presented with a focal choriocarcinoma component. Immunohistochemically, the tumors displayed diffuse positivity for cytokeratin 18, E-cadherin, epidermal growth factor receptor, and p53 and focal positivity for p63 and hCG. However, expression of α-inhibin and placental alkaline phosphatase was almost negative. Tests for human placental lactogen and epithelial membrane antigen were also negative in all cases.

Citations

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  • Epithelioid Trophoblastic Tumour: A Case with Genetic Linkage to a Child Born over Seventeen Years Prior, Successfully Treated with Surgery and Pembrolizumab
    David Pisani, Jean Calleja-Agius, Riccardo Di Fiore, John J. O’Leary, James P. Beirne, Sharon A. O’Toole, Ana Felix, Ian Said-Huntingford
    Current Oncology.2021; 28(6): 5346.     CrossRef
  • Epithelioid Trophoblastic Tumor
    Stephanie M. McGregor, Larissa V. Furtado, Anthony G. Montag, Rebecca Brooks, Ricardo R. Lastra
    International Journal of Gynecological Pathology.2020; 39(1): 8.     CrossRef
  • Epithelioid trophoblastic tumor in a postmenopausal woman: A case report and review of the literature in the postmenopausal group
    Seyran Yigit, Eylul Gun, Bulent Yilmaz, Zafer Kolsuz
    Indian Journal of Pathology and Microbiology.2020; 63(5): 98.     CrossRef
  • Double trouble: Extrauterine epithelioid trophoblastic tumor with uterine choriocarcinoma - An autopsy report
    Kusum Jashnani, Alshifa Yagana, Niraj Mahajan
    Indian Journal of Cancer.2020;[Epub]     CrossRef
  • Epithelioid trophoblastic tumor coexisting with choriocarcinoma around an abdominal wall cesarean scar: a case report and review of the literature
    Chunfeng Yang, Jianqi Li, Yuanyuan Zhang, Hanzhen Xiong, Xiujie Sheng
    Journal of Medical Case Reports.2020;[Epub]     CrossRef
  • Placental site trophoblastic tumor and epithelioid trophoblastic tumor: Clinical and pathological features, prognostic variables and treatment strategy
    Angiolo Gadducci, Silvestro Carinelli, Maria Elena Guerrieri, Giovanni Damiano Aletti
    Gynecologic Oncology.2019; 153(3): 684.     CrossRef
  • Diagnosis and Management of Mixed Gestational Trophoblastic Neoplasia: A Study of 16 Cases and a Review of the Literature
    Yujia Kong, Guangshi Tao, Liju Zong, Junjun Yang, Xirun Wan, Wenze Wang, Yang Xiang
    Frontiers in Oncology.2019;[Epub]     CrossRef
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    Ka Yu Tse, Keith Wan Hang Chiu, Karen Kar Loen Chan, Mandy Man Yee Chu, Siew Fei Ngu, Annie Nga Yin Cheung, Hextan Yuen Sheung Ngan, Philip Pun Ching Ip
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    Sakiko KAGEYAMA, Masafumi KANOTO, Yukio SUGAI, Takeshi SUTO, Satoru NAGASE, Mitsumasa OSAKABE, Takaaki HOSOYA
    Magnetic Resonance in Medical Sciences.2016; 15(4): 411.     CrossRef
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    Fiona Taylor, Barry W Hancock
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  • A Well-Circumscribed Border with Peripheral Doppler Signal in Sonographic Image Distinguishes Epithelioid Trophoblastic Tumor from Other Gestational Trophoblastic Neoplasms
    Jiale Qin, Weiwen Ying, Xiaodong Cheng, Xiaodong Wu, Bingjian Lu, Yun Liang, Xinyu Wang, Xiaoyun Wan, Xing Xie, Weiguo Lu, Hai-Yan Lin
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Benign Triton Tumor: A Rare Entity in Head and Neck Region
Krishnappa Amita, S. Vijay Shankar, Kuchangi C. Nischal, Haleuoor B. Basavaraj
Korean J Pathol. 2013;47(1):74-76.   Published online February 25, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.1.74
  • 5,914 View
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  • 11 Citations
AbstractAbstract PDF

Benign triton tumors (BTT) are very rare lesions composed of mature skeletal muscle and neural tissue. We report a case of a 14-year-old boy who presented with asymptomatic swelling of the chin over an 18-month duration which increased gradually to involve the left side of the lower lip. Clinically, a diagnosis of neurofibroma was made. Excisional biopsy confirmed the diagnosis of a BTT. Having an affinity for large nerve trunks like the brachial and sciatic, these tumors rarely occur in the head and neck region. When they do, they may involve the large central cranial nerve trunk and present as intracranial masses or involve the smaller peripheral nerve twigs and present as asymptomatic skin nodules, of which only four cases involving peripheral nerves are reported in the English literature. Here, we report the fifth documented case of a BTT involving the mental branch of the trigeminal nerve. A brief review of the literature is also provided.

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    Justin D. Rodriguez, A. Morgan Selleck, Ahmed Abdel Khalek Abdel Razek, Benjamin Y. Huang
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    Sophia Peng, Mandana Behbahani, Shelly Sharma, Stacy Speck, Nitin R. Wadhwani, Jeff C. Rastatter, Tord D. Alden
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    Lisa M. Marinelli, Wendi E. Wohltmann, Kevin D. Myers, Geoffrey T. Sasaki
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    Lara Berklite, John Ozolek, Larry Wang, Luisa Santoro, Vittoria Donofrio, Alessandra Stracuzzi, Ivy John, Rita Alaggio
    Pediatric and Developmental Pathology.2021; 24(3): 213.     CrossRef
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    Tae-Sung Joo, Hyejee Kim, In-Ki Park, Jae-Ho Shin
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    Ahmed Abdel Khalek Abdel Razek, Omneya A. Gamaleldin, Nermeen A. Elsebaie
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    Zinon T. Kokkalis, Nikolaos A. Stavropoulos, Andreas F. Mavrogenis, Andreas Panagopoulos, Panayotis N. Soucacos
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    Tatiana Urrea Victoria, Luis Alberto Ruíz Robles, Ana María Vanegas Monroy, Humberto Quintana Muñoz
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    Raj Thakrar, Caroline D. Robson, Sara O. Vargas, John G. Meara, Reza Rahbar, Edward R. Smith
    Pediatric and Developmental Pathology.2014; 17(5): 400.     CrossRef
  • Ectomesenchymoma with Embryonal Rhabdomyosarcoma and Ganglioneuroma, Arising in Association with Benign Triton Tumor of the Tongue
    Katherine A. VandenHeuvel, David F. Carpentieri, Jie Chen, Kar-Ming Fung, David M. Parham
    Pediatric and Developmental Pathology.2014; 17(3): 226.     CrossRef
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    Dong Hyeon Bae, Choong Hyun Kim, Jin Hwan Cheong, Jae Min Kim
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Peripheral Primitive Neuroectodermal Tumor with Osseous Component of the Small Bowel Mesentery: A Case Study
Joon Mee Kim, Young Chae Chu, Chang Hwan Choi, Lucia Kim, Suk Jin Choi, In Suh Park, Jee Young Han, Kyung Rae Kim, Yoon-La Choi, Taeeun Kim
Korean J Pathol. 2013;47(1):77-81.   Published online February 25, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.1.77
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  • 6 Citations
AbstractAbstract PDF

A case of peripheral primitive neuroectodermal tumor of the small bowel mesentery with osseous component is reported. A 23-year-old man was admitted to our hospital because of acute severe abdominal pain. Abdominal computed tomography revealed a large solid and cystic, oval shaped mass, measuring 11.0×6.0 cm in the pelvic cavity. Histologically the resected lesion consisted of sheets of undifferentiated small round cells forming Homer-Wright rosettes and perivascular pseudorosettes, and showed areas of osteoid and bone formation. Immunohistochemical studies revealed that tumor cells expressed positivity against CD99 (MIC2), CD57, neuron-specific enolase, and vimentin. Fluorescence in situ hybridization study revealed Ewing sarcoma breakpoint region 1 (EWSR1) gene rearrangement on chromosome 22q12. To the authors' knowledge this is the first documentation of a peripheral neuroectodermal tumor with osteoid and bone formation of the small bowel mesentery.

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    LIBO PENG, LIMIN YANG, NAN WU, BO WU
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Brief Case Reports
Actinomycotic Brain Abscess Developed 10 Years after Head Trauma
Ki Yong Na, Ji-Hye Jang, Ji-Youn Sung, Youn Wha Kim, Yong-Koo Park
Korean J Pathol. 2013;47(1):82-85.   Published online February 25, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.1.82
  • 6,525 View
  • 40 Download
  • 1 Citations
PDF

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    Manish Kumar, Ankur Bajaj, Manjul Tripathi, BishanD Radotra, ManojK Tewari, ChiragK Ahuja
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Lipoma within Inverted Meckel's Diverticulum: A Case Report
Su-Mi Kim, Min-Jung Jung, Young-Ok Kim
Korean J Pathol. 2013;47(1):86-88.   Published online February 25, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.1.86
  • 5,326 View
  • 50 Download
  • 4 Citations
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    Seungkoo Lee, Seong Whi Cho
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Fine Needle Aspiration Cytology of Postoperative Spindle Cell Nodule in Neck after Thyroidectomy: A Case Report
Myunghee Kang, Seung Yeon Ha, Hyun Yee Cho, Jungsuk An, Dong Hae Chung, Yoo Seung Chung
Korean J Pathol. 2013;47(1):89-91.   Published online February 25, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.1.89
  • 5,882 View
  • 34 Download
  • 2 Citations
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