Journal of Pathology and Translational Medicine

Volume 49(4); July 2015

Reviews

A Review of Inflammatory Processes of the Breast with a Focus on Diagnosis in Core Biopsy Samples: Timothy M. D’Alfonso, Paula S. Ginter, Sandra J. Shin; J Pathol Transl Med. 2015;49(4):279-287. Published online June 22, 2015; DOI: https://doi.org/10.4132/jptm.2015.06.11

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Inflammatory and reactive lesions of the breast are relatively uncommon among benign breast lesions and can be the source of an abnormality on imaging. Such lesions can simulate a malignant process, based on both clinical and radiographic findings, and core biopsy is often performed to rule out malignancy. Furthermore, some inflammatory processes can mimic carcinoma or other malignancy microscopically, and vice versa. Diagnostic difficulty may arise due to the small and fragmented sample of a core biopsy. This review will focus on the pertinent clinical, radiographic, and histopathologic features of the more commonly encountered inflammatory lesions of the breast that can be characterized in a core biopsy sample. These include fat necrosis, mammary duct ectasia, granulomatous lobular mastitis, diabetic mastopathy, and abscess. The microscopic differential diagnoses for these lesions when seen in a core biopsy sample will be discussed.

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Pathology Reporting of Thyroid Core Needle Biopsy: A Proposal of the Korean Endocrine Pathology Thyroid Core Needle Biopsy Study Group: Chan Kwon Jung, Hye Sook Min, Hyo Jin Park, Dong Eun Song, Jang Hee Kim, So Yeon Park, Hyunju Yoo, Mi Kyung Shin, Korean Endocrine Pathology Thyroid Core Needle Biopsy Study Group; J Pathol Transl Med. 2015;49(4):288-299. Published online June 17, 2015; DOI: https://doi.org/10.4132/jptm.2015.06.04

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Abstract PDF

In recent years throughout Korea, the use of ultrasound-guided core needle biopsy (CNB) has become common for the preoperative diagnosis of thyroid nodules. However, there is no consensus on the pathology reporting system for thyroid CNB. The Korean Endocrine Pathology Thyroid Core Needle Biopsy Study Group held a conference on thyroid CNB pathology and developed guidelines through contributions from the participants. This article discusses the outcome of the discussions that led to a consensus on the pathology reporting of thyroid CNB.

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The Utilization of Cytologic Fine-Needle Aspirates of Lung Cancer for Molecular Diagnostic Testing: Michael H. Roh; J Pathol Transl Med. 2015;49(4):300-309. Published online June 16, 2015; DOI: https://doi.org/10.4132/jptm.2015.06.16

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Abstract PDF

In this era of precision medicine, our understanding and knowledge of the molecular landscape associated with lung cancer pathogenesis continues to evolve. This information is being increasingly exploited to treat advanced stage lung cancer patients with tailored, targeted therapy. During the management of these patients, minimally invasive procedures to obtain samples for tissue diagnoses are desirable. Cytologic fine-needle aspirates are often utilized for this purpose and are important not only for rendering diagnoses to subtype patients’ lung cancers, but also for ascertaining molecular diagnostic information for treatment purposes. Thus, cytologic fine-needle aspirates must be utilized and triaged judiciously to achieve both objectives. In this review, strategies in utilizing fine-needle aspirates will be discussed in the context of our current understanding of the clinically actionable molecular aberrations underlying non-small cell lung cancer and the molecular assays applied to these samples in order to obtain treatment-relevant molecular diagnostic information.

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Original Articles

Analysis of Histologic Features Suspecting Anaplastic Lymphoma Kinase (ALK)-Expressing Pulmonary Adenocarcinoma: In Ho Choi, Dong Won Kim, Sang Yun Ha, Yoon-La Choi, Hee Jeong Lee, Joungho Han; J Pathol Transl Med. 2015;49(4):310-317. Published online June 22, 2015; DOI: https://doi.org/10.4132/jptm.2015.05.13

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Abstract PDF

Background
Since 2007 when anaplastic lymphoma kinase (ALK) rearrangements were discovered in non-small cell lung cancer, the ALK gene has received attention due to ALK-targeted therapy, and a notable treatment advantage has been observed in patients harboring the EML4/ALK translocation. However, using ALK-fluorescence in situ hybridization (FISH) as the standard method has demerits such as high cost, a time-consuming process, dependency on interpretation skill, and tissue preparation. We analyzed the histologic findings which could complement the limitation of ALK-FISH test for pulmonary adenocarcinoma. Methods: Two hundred five cases of ALK-positive and 101 of ALK-negative pulmonary adenocarcinoma from January 2007 to May 2013 were enrolled in this study. The histologic findings and ALK immunohistochemistry results were reviewed and compared with the results of ALK-FISH and EGFR/KRAS mutation status. Results: Acinar, cribriform, and solid growth patterns, extracellular and intracellular mucin production, and presence of signet-ring-cell element, and psammoma body were significantly more often present in ALK-positive cancer. In addition, the presence of goblet cell-like cells and presence of nuclear inclusion and groove resembling papillary thyroid carcinoma were common in the ALK-positive group. Conclusions: The above histologic parameters can be helpful in predicting ALK rearranged pulmonary adenocarcinoma, leading to rapid FISH analysis and timely treatment.

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APMIS.2016; 124(10): 832. CrossRef

Cancers with Higher Density of Tumor-Associated Macrophages Were Associated with Poor Survival Rates: Kyong Yeun Jung, Sun Wook Cho, Young A Kim, Daein Kim, Byung-Chul Oh, Do Joon Park, Young Joo Park; J Pathol Transl Med. 2015;49(4):318-324. Published online June 17, 2015; DOI: https://doi.org/10.4132/jptm.2015.06.01

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Abstract PDF

Background
Macrophages are a component of a tumor’s microenvironment and have various roles in tumor progression and metastasis. This study evaluated the relationships between tumor-associated macrophage (TAM) density and clinical outcomes in 14 different types of human cancers. Methods: We investigated TAM density in human tissue microarray sections from 14 different types of human cancers (n = 266) and normal thyroid, lung, and breast tissues (n = 22). The five-year survival rates of each cancer were obtained from the 2011 Korea Central Cancer Registry. Results: Among 13 human cancers, excluding thyroid cancer, pancreas, lung, and gallbladder cancers had the highest density of CD163-positive macrophages (7.0±3.5%, 6.9±7.4%, and 6.9 ± 5.5%, respectively). The five-year relative survival rates of these cancers (pancreas, 8.7%; lung, 20.7%; gallbladder, 27.5%) were lower than those of other cancers. The histological subtypes in thyroid cancer exhibited significantly different CD163-positive macrophages densities (papillary, 1.8 ± 1.6% vs anaplastic, 22.9 ± 17.1%; p < .001), but no significant difference between histological subtypes was detected in lung and breast cancers. Moreover, there was no significant difference in CD163-positive macrophages densities among the TNM stages in lung, breast, and thyroid cancers. Conclusions: Cancers with higher TAM densities (pancreas, lung, anaplastic thyroid, and gallbladder) were associated with poor survival rate.

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Molecular & Cellular Proteomics.2018; 17(6): 1126. CrossRef
Chloroquine and nanoparticle drug delivery: A promising combination
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Conditioned medium from stimulated macrophages inhibits growth but induces an inflammatory phenotype in breast cancer cells
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Potential involvement of neutrophils in human thyroid cancer
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PLOS ONE.2018; 13(6): e0199740. CrossRef
CSF1R-Expressing Tumor-Associated Macrophages, Smoking and Survival in Lung Adenocarcinoma: Analyses Using Quantitative Phosphor-Integrated Dot Staining
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Tumor heterogeneity and nanoparticle-mediated tumor targeting: the importance of delivery system personalization
K. Laxmi Swetha, Aniruddha Roy
Drug Delivery and Translational Research.2018; 8(5): 1508. CrossRef
Immune Gene Signature Delineates a Subclass of Papillary Thyroid Cancer with Unfavorable Clinical Outcomes
Kyuryung Kim, Sora Jeon, Tae-Min Kim, Chan Jung
Cancers.2018; 10(12): 494. CrossRef
Bone marrow-derived cells are recruited by the melanoma tumor with endothelial cells contributing to tumor vasculature
R. Bonfim-Silva, L. E. B. Souza, F. U. F. Melo, V. C. Oliveira, D. A. R. Magalhães, H. F. Oliveira, D. T. Covas, A. M. Fontes
Clinical and Translational Oncology.2017; 19(1): 125. CrossRef
Stromal contributions to the carcinogenic process
Mark Spaw, Shrikant Anant, Sufi Mary Thomas
Molecular Carcinogenesis.2017; 56(4): 1199. CrossRef
The Role of Cancer-Associated Fibroblasts and Fibrosis in Liver Cancer
Silvia Affo, Le-Xing Yu, Robert F. Schwabe
Annual Review of Pathology: Mechanisms of Disease.2017; 12(1): 153. CrossRef
PEDF increases the tumoricidal activity of macrophages towards prostate cancer cells in vitro
Dalia Martinez-Marin, Courtney Jarvis, Thomas Nelius, Werner de Riese, Olga V. Volpert, Stéphanie Filleur, Chih-Hsin Tang
PLOS ONE.2017; 12(4): e0174968. CrossRef
Anaplastic thyroid carcinoma: from clinicopathology to genetics and advanced therapies
Eleonora Molinaro, Cristina Romei, Agnese Biagini, Elena Sabini, Laura Agate, Salvatore Mazzeo, Gabriele Materazzi, Stefano Sellari-Franceschini, Alessandro Ribechini, Liborio Torregrossa, Fulvio Basolo, Paolo Vitti, Rossella Elisei
Nature Reviews Endocrinology.2017; 13(11): 644. CrossRef
Iron Induces Anti-tumor Activity in Tumor-Associated Macrophages
Milene Costa da Silva, Michael O. Breckwoldt, Francesca Vinchi, Margareta P. Correia, Ana Stojanovic, Carl Maximilian Thielmann, Michael Meister, Thomas Muley, Arne Warth, Michael Platten, Matthias W. Hentze, Adelheid Cerwenka, Martina U. Muckenthaler
Frontiers in Immunology.2017;[Epub] CrossRef
Reprogramming Tumor-Associated Macrophages To Reverse EGFRT790M Resistance by Dual-Targeting Codelivery of Gefitinib/Vorinostat
Huige Peng, Binfan Chen, Wei Huang, Yubo Tang, Yifan Jiang, Wenyuan Zhang, Yongzhuo Huang
Nano Letters.2017; 17(12): 7684. CrossRef
Numerical modeling of nanodrug distribution in tumors with heterogeneous vasculature
Cheng-Ying Chou, Wan-I Chang, Tzyy-Leng Horng, Win-Li Lin, Han-Chung Wu
PLOS ONE.2017; 12(12): e0189802. CrossRef
HPMA–Copolymer Nanocarrier Targets Tumor-Associated Macrophages in Primary and Metastatic Breast Cancer
Melissa N. Zimel, Chloe B. Horowitz, Vinagolu K. Rajasekhar, Alexander B. Christ, Xin Wei, Jianbo Wu, Paulina M. Wojnarowicz, Dong Wang, Steven R. Goldring, P. Edward Purdue, John H. Healey
Molecular Cancer Therapeutics.2017; 16(12): 2701. CrossRef
Correlation of tumor-associated macrophages and NK cells with bladder cancer size and T stage in patients with solitary low-grade urothelial carcinoma
Kristian Krpina, Emina Babarović, Josip Španjol, Gordana Đorđević, Tobias Maurer, Nives Jonjić
Wiener klinische Wochenschrift.2016; 128(7-8): 248. CrossRef
The lymphatic system and pancreatic cancer
Darci M. Fink, Maria M. Steele, Michael A. Hollingsworth
Cancer Letters.2016; 381(1): 217. CrossRef
Jacalin-Activated Macrophages Exhibit an Antitumor Phenotype
Cláudia Danella Polli, Luciana Pereira Ruas, Luciana Chain Veronez, Thais Herrero Geraldino, Fabiana Rossetto de Morais, Maria Cristina Roque-Barreira, Gabriela Pereira-da-Silva
BioMed Research International.2016; 2016: 1. CrossRef
The immune network in thyroid cancer
Maria Rosaria Galdiero, Gilda Varricchi, Gianni Marone
OncoImmunology.2016; 5(6): e1168556. CrossRef
The Expression and Relationship of CD68-Tumor-Associated Macrophages and Microvascular Density With the Prognosis of Patients With Laryngeal Squamous Cell Carcinoma
Shujun Sun, Xinliang Pan, Limin Zhao, Jianming Zhou, Hongzeng Wang, Yonghong Sun
Clinical and Experimental Otorhinolaryngology.2016; 9(3): 270. CrossRef
Role of pulmonary macrophages in initiation of lung metastasis in anaplastic thyroid cancer
Xiu Juan Li, Prakash Gangadaran, Senthilkumar Kalimuthu, Ji Min Oh, Liya Zhu, Shin Young Jeong, Sang‐Woo Lee, Jaetae Lee, Byeong‐Cheol Ahn
International Journal of Cancer.2016; 139(11): 2583. CrossRef
Perspectives for immunotherapy in endocrine cancer
S Latteyer, V Tiedje, B Schilling, D Führer
Endocrine-Related Cancer.2016; 23(10): R469. CrossRef
Macrophage Densities Correlated with CXC Chemokine Receptor 4 Expression and Related with Poor Survival in Anaplastic Thyroid Cancer
Dae In Kim, Eunyoung Kim, Young A Kim, Sun Wook Cho, Jung Ah Lim, Young Joo Park
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High expression of C-C chemokine receptor 2 associates with poor overall survival in gastric cancer patients after surgical resection
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Case Studies

WHO Grade IV Gliofibroma: A Grading Label Denoting Malignancy for an Otherwise Commonly Misinterpreted Neoplasm: Paola A. Escalante Abril, Miguel Fdo. Salazar, Nubia L. López García, Mónica N. Madrazo Moya, Yadir U. Zamora Guerra, Yadira Gandhi Mata Mendoza, Erick Gómez Apo, Laura G. Chávez Macías; J Pathol Transl Med. 2015;49(4):325-330. Published online June 17, 2015; DOI: https://doi.org/10.4132/jptm.2015.05.20; Correction in: J Pathol Transl Med 2015;49(6):538

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We report a 50-year-old woman with no relevant clinical history who presented with headache and loss of memory. Magnetic resonance imaging showed a left parieto-temporal mass with annular enhancement after contrast media administration, rendering a radiological diagnosis of high-grade astrocytic neoplasm. Tumour sampling was performed but the patient ultimately died as a result of disease. Microscopically, the lesion had areas of glioblastoma mixed with a benign mesenchymal constituent; the former showed hypercellularity, endothelial proliferation, high mitotic activity and necrosis, while the latter showed fascicles of long spindle cells surrounded by collagen and reticulin fibers. With approximately 40 previously reported cases, gliofibroma is a rare neoplasm defined as either glio-desmoplastic or glial/benign mesenchymal. As shown in our case, its prognosis is apparently determined by the degree of anaplasia of the glial component.

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Rare Pediatric Invasive Gliofibroma Has BRAFV600E Mutation and Transiently Responds to Targeted Therapy Before Progressive Clonal Evolution
Kristiyana Kaneva, Kee Kiat Yeo, Debra Hawes, Jianling Ji, Jaclyn A. Biegel, Marvin D. Nelson, Stefan Bluml, Mark D. Krieger, Anat Erdreich-Epstein
JCO Precision Oncology.2019; (3): 1. CrossRef

A Rare Case of Primary Tubular Adenocarcinoma of the Thymus, Enteric Immunophenotype: A Case Study and Review of the Literature: Hae Yoen Jung, Hyundeuk Cho, Jin-Haeng Chung, Sang Byoung Bae, Ji-Hye Lee, Hyun Ju Lee, Si-Hyong Jang, Mee-Hye Oh; J Pathol Transl Med. 2015;49(4):331-334. Published online June 1, 2015; DOI: https://doi.org/10.4132/jptm.2015.04.16

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Thymic carcinomas are uncommon malignant tumors, and thymic adenocarcinomas are extremely rare. Here, we describe a case of primary thymic adenocarcinoma in a 59-year-old woman. Histological examination of the tumor revealed tubular morphology with expression of cytokeratin 20 and caudal-type homeobox 2 according to immunohistochemistry, suggesting enteric features. Extensive clinical and radiological studies excluded the possibility of an extrathymic primary tumor. A review of the literature revealed only two global cases of primary tubular adenocarcinomas of the thymus with enteric immunophenotype.

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Case report: Primary adenocarcinoma NOS of the thymus and cytological features
Jonathan Willner, Osvaldo Hernandez, Lea Azour, Andre L. Moreira
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Metastatic thymic-enteric adenocarcinoma responding to chemoradiation plus anti-angiogenic therapy: A case report
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Yuuki Kou, Hirokazu Tanaka, Nobuhisa Yamazaki, Hiroyoshi Watanabe, Makoto Sonobe
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Histologic characteristics of thymic adenocarcinomas: Clinicopathologic study of a nine-case series and a review of the literature
Ah-Young Kwon, Joungho Han, Jinah Chu, Yong Soo Choi, Byeong-Ho Jeong, Myung-Ju Ahn, Yong Chan Ahn
Pathology - Research and Practice.2017; 213(2): 106. CrossRef
Characterization of genetic aberrations in a single case of metastatic thymic adenocarcinoma
Yeonghun Lee, Sehhoon Park, Se-Hoon Lee, Hyunju Lee
BMC Cancer.2017;[Epub] CrossRef
Cytologic Characteristics of Thymic Adenocarcinoma with Enteric Differentiation: A Study of Four Fine-Needle Aspiration Specimens
Ah-Young Kwon, Joungho Han, Hae-yon Cho, Seokhwi Kim, Heejin Bang, Jiyeon Hyeon
Journal of Pathology and Translational Medicine.2017; 51(5): 509. CrossRef
Mucinous cystic tumor with CK20 and CDX2 expression of the thymus: Is this a benign counterpart of adenocarcinoma of the thymus, enteric type?
Jun Akiba, Hiroshi Harada, Shintaro Yokoyama, Toshihiro Hashiguchi, Akihiko Kawahara, Masahiro Mitsuoka, Shinzo Takamori, Hirohisa Yano
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Colon cancer chemotherapy for a patient with CDX2-expressing metastatic thymic adenocarcinoma: a case report and literature review
Akihiko Sawaki, Mikiya Ishihara, Yuji Kozuka, Hiroyasu Oda, Satoshi Tamaru, Yumiko Sugawara, Yoshiki Yamashita, Toshiro Mizuno, Taizo Shiraishi, Naoyuki Katayama
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Mina Lee, Suk Jin Choi, Yong Han Yoon, Joung-Taek Kim, Wan Ki Baek, Young Sam Kim
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Brief Case Reports

Sclerosing Extramedullary Hematopoietic Tumor Mimicking Intra-abdominal Sarcoma: Serap Karaarslan, Nalan Nese, Guray Oncel, Nazan Ozsan, Taner Akalin, Hasan Kaplan, Filiz Buyukkececi, Mine Hekimgil; J Pathol Transl Med. 2015;49(4):335-338. Published online June 15, 2015; DOI: https://doi.org/10.4132/jptm.2015.04.22

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Sclerosing Extramedullary Hematopoietic Tumor (SEHT) Mimicking a Malignant Bile Duct Tumor-Case Report and Literature Review
Sorin Dema, Fulger Lazar, Robert Barna, Amadeus Dobrescu, Alis Liliana Carmen Dema, Oana Popa, Ioana Ionita, Sorina Maria Taban
Medicina.2021; 57(8): 824. CrossRef
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Dapeng Wang, Eduardo Castro, Arundhati Rao, Christopher Michael McPhaul
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Ureteral Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue, Chronic Inflammation, and Renal Artery Atherosclerosis: Hojung Lee, Jong Eun Joo, Young Ok Hong, Won Mi Lee, Eun Kyung Kim, Jeong Joo Woo, Soo Jung Gong, Jooryung Huh; J Pathol Transl Med. 2015;49(4):339-342. Published online June 1, 2015; DOI: https://doi.org/10.4132/jptm.2015.04.28

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Late Bone Metastasis of Histologically Bland Struma Ovarii: The Unpredictability of Its Biologic Behavior: Sun-Ju Oh, Minjung Jung, Young-Ok Kim; J Pathol Transl Med. 2015;49(4):343-345. Published online June 15, 2015; DOI: https://doi.org/10.4132/jptm.2015.04.27

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JBJS Case Connector.2017; 7(4): e82. CrossRef

Necrotizing Sarcoid Granulomatosis: Possibly Veiled Disease in Endemic Area of Mycobacterial Infection: Yosep Chong, Eun Jung Lee, Chang Suk Kang, Tae-Jung Kim, Jung Sup Song, Hyosup Shim; J Pathol Transl Med. 2015;49(4):346-350. Published online June 1, 2015; DOI: https://doi.org/10.4132/jptm.2015.04.17

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Salivary Gland Hyalinizing Clear Cell Carcinoma: Jung-Chia Lin, Jia-Bin Liao, Hsiao-Ting Fu, Ting-Shou Chang, Jyh-Seng Wang; J Pathol Transl Med. 2015;49(4):351-353. Published online June 16, 2015; DOI: https://doi.org/10.4132/jptm.2015.05.06

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