Journal of Pathology and Translational Medicine

Original Article

Immunohistochemical expression in idiopathic inflammatory myopathies at a single center in Vietnam: Dat Quoc Ngo, Si Tri Le, Khanh Hoang Phuong Phan, Thao Thi Phuong Doan, Linh Ngoc Khanh Nguyen, Minh Hoang Dang, Thien Thanh Ly, Thu Dang Anh Phan; J Pathol Transl Med. 2024;58(4):174-181. Published online June 25, 2024; DOI: https://doi.org/10.4132/jptm.2024.05.02

1,139 View
226 Download

Abstract PDF: Background
The identification of idiopathic inflammatory myopathies (IIMs) requires a comprehensive analysis involving clinical manifestations and histological findings. This study aims to provide insights into the histopathological and immunohistochemical aspects of IIMs.
Methods
This retrospective case series involved 56 patients diagnosed with IIMs at the Department of Pathology, University of Medicine and Pharmacy at Ho Chi Minh City, from 2019 to 2023. The histology and immunohistochemical expression of HLA-ABC, HLA-DR, C5b-9, Mx1/2/3, and p62 were detected.
Results
We examined six categories of inflammatory myopathy, including immunemediated necrotizing myopathy (58.9%), dermatomyositis (DM; 23.2%), overlap myositis (8.9%), antisynthetase syndrome (5.4%), inclusion body myositis (IBM; 1.8%), and polymyositis (1.8%). The average age of the patients was 49.7 ± 16.1 years, with a female-to-male ratio of 3:1. Inflammatory cell infiltration in the endomysium was present in 62.5% of cases, perifascicular atrophy was found in 17.8%, and fiber necrosis was observed in 42 cases (75.0%). Rimmed vacuoles were present in 100% of cases in the IBM group. Immunohistochemistry showed the following positivity rates: HLA-ABC (89.2%), HLA-DR (19.6%), C5b-9 (57.1%), and Mx1/2/3 (10.7%). Mx1/2/3 expression was high in DM cases. p62 vacuole deposits were noted in the IBM case. The combination of membrane attack complex and major histocompatibility complex I helped detect IIMs in 96% of cases.
Conclusions
The diagnosis of IIMs and their subtypes should be based on clinical features and histopathological characteristics. Immunohistochemistry plays a crucial role in the diagnosis and differentiation of these subgroups.

Case Study

Primary epithelioid inflammatory myofibroblastic sarcoma of the brain with EML4::ALK fusion mimicking intra-axial glioma: a case report and brief literature review: Eric Eunshik Kim, Chul-Kee Park, Koung Mi Kang, Yoonjin Kwak, Sung-Hye Park, Jae-Kyung Won; J Pathol Transl Med. 2024;58(3):141-145. Published online May 14, 2024; DOI: https://doi.org/10.4132/jptm.2024.04.12

1,664 View
179 Download

Abstract PDF: An aggressive subtype of inflammatory myofibroblastic tumor, epithelioid inflammatory myofibroblastic sarcoma occurs primarily inside the abdominal cavity, followed by a pulmonary localization. Most harbor anaplastic lymphoma kinase (ALK) gene rearrangements, with RANBP2 and RRBP1 among the well-documented fusion partners. We report the second case of primary epithelioid inflammatory myofibroblastic sarcoma of the brain, with a well-known EML4::ALK fusion. The case is notable for its intra-axial presentation that clinico-radiologically mimicked glioma.

Review

Inflammatory bowel disease–associated intestinal fibrosis: Ji Min Park, Jeongseok Kim, Yoo Jin Lee, Sung Uk Bae, Hye Won Lee; J Pathol Transl Med. 2023;57(1):60-66. Published online January 10, 2023; DOI: https://doi.org/10.4132/jptm.2022.11.02

6,569 View
326 Download
16 Web of Science
15 Crossref

Abstract PDF

Fibrosis is characterized by a proliferation of fibroblasts and excessive extracellular matrix following chronic inflammation, and this replacement of organ tissue with fibrotic tissue causes a loss of function. Inflammatory bowel disease (IBD) is a chronic inflammation of the gastrointestinal tract, and intestinal fibrosis is common in IBD patients, resulting in several complications that require surgery, such as a stricture or penetration. This review describes the pathogenesis and various factors involved in intestinal fibrosis in IBD, including cytokines, growth factors, epithelial-mesenchymal and endothelial-mesenchymal transitions, and gut microbiota. Furthermore, histopathologic findings and scoring systems used for stenosis in IBD are discussed, and differences in the fibrosis patterns of ulcerative colitis and Crohn’s disease are compared. Biomarkers and therapeutic agents targeting intestinal fibrosis are briefly mentioned at the end.

Citations

Citations to this article as recorded by

Resistance to apoptosis in complicated Crohn's disease: Relevance in ileal fibrosis
M. Seco-Cervera, D. Ortiz-Masiá, D.C. Macias-Ceja, S. Coll, L. Gisbert-Ferrándiz, J. Cosín-Roger, C. Bauset, M. Ortega, B. Heras-Morán, F. Navarro-Vicente, M. Millán, J.V. Esplugues, S. Calatayud, M.D. Barrachina
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2024; 1870(2): 166966. CrossRef
Characterization of patient-derived intestinal organoids for modelling fibrosis in Inflammatory Bowel Disease
Ilaria Laudadio, Claudia Carissimi, Noemi Scafa, Alex Bastianelli, Valerio Fulci, Alessandra Renzini, Giusy Russo, Salvatore Oliva, Roberta Vitali, Francesca Palone, Salvatore Cucchiara, Laura Stronati
Inflammation Research.2024; 73(8): 1359. CrossRef
Food additives impair gut microbiota from healthy individuals and IBD patients in a colonic in vitro fermentation model
Irma Gonza, Elizabeth Goya-Jorge, Caroline Douny, Samiha Boutaleb, Bernard Taminiau, Georges Daube, Marie–Louise Scippo, Edouard Louis, Véronique Delcenserie
Food Research International.2024; 182: 114157. CrossRef
Epigenetic Regulation of EMP/EMT-Dependent Fibrosis
Margherita Sisto, Sabrina Lisi
International Journal of Molecular Sciences.2024; 25(5): 2775. CrossRef
Mechanisms and therapeutic research progress in intestinal fibrosis
Yanjiang Liu, Tao Zhang, Kejian Pan, He Wei
Frontiers in Medicine.2024;[Epub] CrossRef
Disease clearance in ulcerative colitis: A new therapeutic target for the future
Syed Adeel Hassan, Neeraj Kapur, Fahad Sheikh, Anam Fahad, Somia Jamal
World Journal of Gastroenterology.2024; 30(13): 1801. CrossRef
Urinary Hydroxyproline as an Inflammation-Independent Biomarker of Inflammatory Bowel Disease
Muriel Huss, Tanja Elger, Johanna Loibl, Arne Kandulski, Benedicta Binder, Petra Stoeckert, Patricia Mester, Martina Müller, Christa Buechler, Hauke Christian Tews
Gastroenterology Insights.2024; 15(2): 486. CrossRef
Inflammatory Bowel Disease: Immune Function, Tissue Fibrosis and Current Therapies
Jesús Cosín-Roger
International Journal of Molecular Sciences.2024; 25(12): 6416. CrossRef
The Diagnosis of Intestinal Fibrosis in Crohn’s Disease—Present and Future
Sara Jarmakiewicz-Czaja, Jolanta Gruszecka, Rafał Filip
International Journal of Molecular Sciences.2024; 25(13): 6935. CrossRef
Role of gut microbiota in Crohn’s disease pathogenesis: Insights from fecal microbiota transplantation in mouse model
Qiang Wu, Lian-Wen Yuan, Li-Chao Yang, Ya-Wei Zhang, Heng-Chang Yao, Liang-Xin Peng, Bao-Jia Yao, Zhi-Xian Jiang
World Journal of Gastroenterology.2024; 30(31): 3689. CrossRef
Ultrasound of the bowel with a focus on IBD: the new best practice
Christina Merrill, Stephanie R. Wilson
Abdominal Radiology.2024;[Epub] CrossRef
Unveiling the anti-inflammatory potential of 11β,13-dihydrolactucin for application in inflammatory bowel disease management
Melanie S. Matos, María Ángeles Ávila-Gálvez, Antonio González-Sarrías, Nuno-Valério Silva, Carolina Lage Crespo, António Jacinto, Ana Teresa Serra, Ana A. Matias, Cláudia Nunes dos Santos
Food & Function.2024; 15(18): 9254. CrossRef
Pathways Affected by Falcarinol-Type Polyacetylenes and Implications for Their Anti-Inflammatory Function and Potential in Cancer Chemoprevention
Ruyuf Alfurayhi, Lei Huang, Kirsten Brandt
Foods.2023; 12(6): 1192. CrossRef
Time to eRAASe chronic inflammation: current advances and future perspectives on renin-angiotensin-aldosterone-system and chronic intestinal inflammation in dogs and humans
Romy M. Heilmann, Georg Csukovich, Iwan A. Burgener, Franziska Dengler
Frontiers in Veterinary Science.2023;[Epub] CrossRef
Role of the epithelial barrier in intestinal fibrosis associated with inflammatory bowel disease: relevance of the epithelial-to mesenchymal transition
Dulce C. Macias-Ceja, M. Teresa Mendoza-Ballesteros, María Ortega-Albiach, M. Dolores Barrachina, Dolores Ortiz-Masià
Frontiers in Cell and Developmental Biology.2023;[Epub] CrossRef

Case Study

Primary pulmonary epithelioid inflammatory myofibroblastic sarcoma: a rare entity and a literature review: Priyanka Singh, Aruna Nambirajan, Manish Kumar Gaur, Rahul Raj, Sunil Kumar, Prabhat Singh Malik, Deepali Jain; J Pathol Transl Med. 2022;56(4):231-237. Published online July 7, 2022; DOI: https://doi.org/10.4132/jptm.2022.05.08

3,063 View
114 Download
8 Web of Science
7 Crossref

Abstract PDF

Epithelioid inflammatory myofibroblastic sarcoma (EIMS) is an aggressive subtype of inflammatory myofibroblastic tumor (IMT) harboring anaplastic lymphoma kinase (ALK) gene fusions and is associated with high risk of local recurrence and poor prognosis. Herein, we present a young, non-smoking male who presented with complaints of cough and dyspnoea and was found to harbor a large right lower lobe lung mass. Biopsy showed a high-grade epithelioid to rhabdoid tumor with ALK and desmin protein expression. The patient initially received 5 cycles of crizotinib and remained stable for 1 year; however, he then developed multiple bony metastases, for which complete surgical resection was performed. Histopathology confirmed the diagnosis of EIMS, with ALK gene rearrangement demonstrated by fluorescence in situ hybridization. Postoperatively, the patient is asymptomatic with stable metastatic disease on crizotinib and has been started on palliative radiotherapy. EIMS is a very rare subtype of IMT that needs to be included in the differential diagnosis of ALKexpressing lung malignancies in young adults.

Citations

Citations to this article as recorded by

Mediastinal epithelioid inflammatory myofibroblastic sarcoma with the EML4‐ALK fusion: A case report and literature review
Tingyu Pan, Xinyu Sun, Xiao Wu, Futing Tang, Xianmei Zhou, Qian Wang, Shi Chen
Respirology Case Reports.2024;[Epub] CrossRef
Primary epithelioid inflammatory myofibroblastic sarcoma of the brain with EML4::ALK fusion mimicking intra-axial glioma: a case report and brief literature review
Eric Eunshik Kim, Chul-Kee Park, Koung Mi Kang, Yoonjin Kwak, Sung-Hye Park, Jae-Kyung Won
Journal of Pathology and Translational Medicine.2024; 58(3): 141. CrossRef
Epithelioid Inflammatory Myofibroblastic Sarcoma: A Report of a Rare Case
Varun Ronanki, Vaddatti Tejeswini, Inuganti Venkata Renuka, Shaik Raheema, Bakkamanthala S K Kanth
Cureus.2024;[Epub] CrossRef
Thoracic epithelioid inflammatory myofibroblastic sarcoma: a rare and aggressive disease with case report and literature review
Linke Yang, Pei Li, Runze Liu, Baomin Feng, Huiqing Mao, Xiaoyong Tang, Guangjian Yang
Discover Oncology.2024;[Epub] CrossRef
Case report: Epithelioid inflammatory myofibroblastic sarcoma treated with an ALK TKI ensartinib
Mengmeng Li, Ruyue Xing, Jiuyan Huang, Chao Shi, Chunhua Wei, Huijuan Wang
Frontiers in Oncology.2023;[Epub] CrossRef
Epithelioid Inflammatory Myofibroblastic Sarcoma With Poor Response to Crizotinib: A Case Report
Soheila Aminimoghaddam, Roghayeh Pourali
Clinical Medicine Insights: Case Reports.2023;[Epub] CrossRef
Epithelioid inflammatory myofibroblastic sarcoma: a case report and brief literature review
Weidong Dou, Yu Guan, Tao Liu, Hang Zheng, Shuo Feng, Yingchao Wu, Xin Wang, Zhanbing Liu
Frontiers in Oncology.2023;[Epub] CrossRef

Review

Non-conventional dysplastic subtypes in inflammatory bowel disease: a review of their diagnostic characteristics and potential clinical implications: Won-Tak Choi; J Pathol Transl Med. 2021;55(2):83-93. Published online March 9, 2021; DOI: https://doi.org/10.4132/jptm.2021.02.17

5,753 View
358 Download
16 Web of Science
17 Crossref

Abstract PDF

The early detection and grading of dysplasia is the current standard of care to minimize mortality from colorectal cancer (CRC) in patients with inflammatory bowel disease. With the development of advanced endoscopic resection techniques, colectomy is now reserved for patients with invisible/flat dysplasia (either high-grade [HGD] or multifocal low-grade dysplasia) or endoscopically unresectable lesions. Although most pathologists are familiar with the morphologic criteria of conventional (intestinal type) dysplasia, the most well-recognized form of dysplasia, an increasing number of diagnostic material has led to the recognition of several different morphologic patterns of epithelial dysplasia. The term “non-conventional” dysplasia has been coined to describe these changes, but to date, the recognition and full appreciation of these novel forms of dysplasia by practicing pathologists is uneven. The recognition of these non-conventional subtypes is becoming increasingly important, as some of them appear to have a higher risk of developing HGD or CRC than conventional dysplasia or sporadic adenomas. This review describes the morphologic characteristics of all seven non-conventional subtypes that have been reported to date as well as our current understanding of their clinicopathologic and molecular features that distinguish them from conventional dysplasia or sporadic adenomas.

Citations

Citations to this article as recorded by

Recently described types of dysplasia associated with IBD: tips and clues for the practising pathologist
Zahra Alipour, Kristen Stashek
Journal of Clinical Pathology.2024; 77(2): 77. CrossRef
Nonconventional Dysplasia is Frequently Associated With Goblet Cell Deficient and Serrated Variants of Colonic Adenocarcinoma in Inflammatory Bowel Disease
Andrew Xiao, Masato Yozu, Bence P. Kővári, Lindsay Yassan, Xiaoyan Liao, Marcela Salomao, Maria Westerhoff, Anita Sejben, Gregory Y. Lauwers, Won-Tak Choi
American Journal of Surgical Pathology.2024; 48(6): 691. CrossRef
Increased Active Inflammation in the Colon is Not a Reliable Predictor of an Elevated Risk of Dysplasia in Patients With Primary Sclerosing Cholangitis and Ulcerative Colitis
Ruth Zhang, Dongliang Wang, Gregory Y. Lauwers, Won-Tak Choi
American Journal of Surgical Pathology.2024; 48(9): 1154. CrossRef
Dysplasia Detected in Patients With Serrated Epithelial Change Is Frequently Associated With an Invisible or Flat Endoscopic Appearance, Nonconventional Dysplastic Features, and Advanced Neoplasia
Dorukhan Bahceci, Lindsay Alpert, Tanner Storozuk, Xiaoyan Liao, Masato Yozu, Maria Westerhoff, Bence P. Kővári, Gregory Y. Lauwers, Won-Tak Choi
American Journal of Surgical Pathology.2024; 48(10): 1326. CrossRef
Difficulties in diagnosis of non-conventional dysplasia in inflammatory bowel disease
Kh. M. Akhrieva, A. S. Tertychnyy, N. V. Pachuashvili, L. S. Urusova
Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH).2024; 14(3): 21. CrossRef
Hypermucinosus és kehelysejtszegény, gyulladásos bélbetegséghez társult, non-conventionalis dysplasia colorectalis adenocarcinoma mellett
Szintia Almási, Bence Baráth, Panna Szaszák, Bence Kővári, Anita Sejben
Orvosi Hetilap.2023; 164(51): 2039. CrossRef
DNA content abnormality frequently develops in the right/proximal colon in patients with primary sclerosing cholangitis and inflammatory bowel disease and is highly predictive of subsequent detection of dysplasia
Ruth Zhang, Peter S. Rabinovitch, Aras N. Mattis, Gregory Y. Lauwers, Won‐Tak Choi
Histopathology.2023; 83(1): 116. CrossRef
Non‐conventional dysplasia is frequently associated with low‐grade tubuloglandular and mucinous adenocarcinomas in inflammatory bowel disease
Fahire Goknur Akarca, Masato Yozu, Lindsay Alpert, Bence P Kővári, Lei Zhao, Marcela Salomao, Xiaoyan Liao, Maria Westerhoff, Gregory Y Lauwers, Won‐Tak Choi
Histopathology.2023; 83(2): 276. CrossRef
The yield of dysplasia and serrated lesions in a single-centre tertiary inflammatory bowel disease cohort
Fiona Yeaman, Lena Thin
Therapeutic Advances in Gastroenterology.2023;[Epub] CrossRef
MYC overexpression in inflammatory bowel disease-associated conventional dysplasia and association of subsequent low-grade dysplasia in follow-up biopsies
Yuanxin Liang, Yansheng Hao, Yiqin Xiong, Minghao Zhong, Dhanpat Jain
Pathology - Research and Practice.2023; 248: 154642. CrossRef
Characteristics, Reporting, and Potential Clinical Significance of Nonconventional Dysplasia in Inflammatory Bowel Disease
Won-Tak Choi
Surgical Pathology Clinics.2023; 16(4): 687. CrossRef
Using of endoscopic polypectomy in patients with diagnosed malignant colorectal polyp – The cross-sectional clinical study
Vladislava Stojic, Natasa Zdravkovic, Tamara Nikolic-Turnic, Nebojsa Zdravkovic, Jelena Dimitrijevic, Aleksandra Misic, Kristijan Jovanovic, Stefan Milojevic, Jelena Zivic
Open Medicine.2023;[Epub] CrossRef
Morphological subtypes of colorectal low-grade intraepithelial neoplasia: diagnostic reproducibility, frequency and clinical impact
Corinna Lang-Schwarz, Maike Büttner-Herold, Stephan Burian, Ramona Erber, Arndt Hartmann, Moritz Jesinghaus, Kateřina Kamarádová, Carlos A Rubio, Gerhard Seitz, William Sterlacci, Michael Vieth, Simone Bertz
Journal of Clinical Pathology.2023; : jcp-2023-209206. CrossRef
And the story goes on: non-conventional dysplasia of the colorectum
Lavisha S. Punjabi, Yi Neng Lai, Anjula Thomas
Journal of Pathology and Translational Medicine.2022; 56(2): 109. CrossRef
Clinicopathologic features of undetected dysplasia found in total colectomy or proctocolectomy specimens of patients with inflammatory bowel disease
Dorukhan Bahceci, Gregory Y Lauwers, Won‐Tak Choi
Histopathology.2022; 81(2): 183. CrossRef
Increased Risk of Non-conventional and Invisible Dysplasias in Patients with Primary Sclerosing Cholangitis and Inflammatory Bowel Disease
Ruth Zhang, Gregory Y Lauwers, Won-Tak Choi
Journal of Crohn's and Colitis.2022; 16(12): 1825. CrossRef
Increased histologic inflammation is an independent risk factor for nonconventional dysplasia in ulcerative colitis
Eric D. Nguyen, Dongliang Wang, Gregory Y. Lauwers, Won‐Tak Choi
Histopathology.2022; 81(5): 644. CrossRef

Original Article

Quilty Lesions in the Endomyocardial Biopsies after Heart Transplantation: Haeyon Cho, Jin-Oh Choi, Eun-Seok Jeon, Jung-Sun Kim; J Pathol Transl Med. 2019;53(1):50-56. Published online December 26, 2018; DOI: https://doi.org/10.4132/jptm.2018.11.30

6,251 View
125 Download
5 Web of Science
5 Crossref

Abstract PDF Supplementary Material

Background
The aim of this study was to investigate the clinical significance of Quilty lesions in endomyocardial biopsies (EMBs) of cardiac transplantation patients.
Methods
A total of 1190EMBs from 117 cardiac transplantation patients were evaluated histologically for Quilty lesions,acute cellular rejection, and antibody-mediated rejection. Cardiac allograft vasculopathy wasdiagnosed by computed tomography coronary angiography. Clinical information, including thepatients’ survival was retrieved by a review of medical records.
Results
Eighty-eight patients(75.2%) were diagnosed with Quilty lesions, which were significantly associated with acute cellularrejection, but not with acute cellular rejection ≥ 2R or antibody-mediated rejection. In patientsdiagnosed with both Quilty lesions and acute cellular rejection, the time-to-onset of Quilty lesionsfrom transplantation was longer than that of acute cellular rejections. We found a significant associationbetween Quilty lesions and cardiac allograft vasculopathy. No significant relationship wasfound between Quilty lesions and the patients’ survival.
Conclusions
Quilty lesion may be an indicator of previous acute cellular rejection rather than a predictor for future acute cellular rejection.

Citations

Citations to this article as recorded by

The human myocardium harbors a population of naive B-cells with a distinctive gene expression signature conserved across species
Kevin C. Bermea, Nicolas Kostelecky, Sylvie T. Rousseau, Chieh-Yu Lin, Luigi Adamo
Frontiers in Immunology.2022;[Epub] CrossRef
Examination of tracheal allografts after long-term survival in dogs
Tao Lu, Yiwei Huang, Yulei Qiao, Yongxing Zhang, Yu Liu
European Journal of Cardio-Thoracic Surgery.2021; 59(1): 155. CrossRef
Essentials in the diagnosis of postoperative myocardial lesions similar to or unrelated to rejection in heart transplant
Costel Dumitru, Ancuta Zazgyva, Adriana Habor, Ovidiu Cotoi, Horațiu Suciu, Carmen Cotrutz, Bogdan Grecu, Ileana Anca Sin
Revista Romana de Medicina de Laborator.2021; 29(3): 307. CrossRef
Clinical outcome of donor heart with prolonged cold ischemic time: A single‐center study
Fazal Shafiq, Yixuan Wang, Geng Li, Zongtao Liu, Fei Li, Ying Zhou, Li Xu, Xingjian Hu, Nianguo Dong
Journal of Cardiac Surgery.2020; 35(2): 397. CrossRef
The XVth Banff Conference on Allograft Pathology the Banff Workshop Heart Report: Improving the diagnostic yield from endomyocardial biopsies and Quilty effect revisited
Jean-Paul Duong Van Huyen, Marny Fedrigo, Gregory A. Fishbein, Ornella Leone, Desley Neil, Charles Marboe, Eliot Peyster, Jan von der Thüsen, Alexandre Loupy, Michael Mengel, Monica P. Revelo, Benjamin Adam, Patrick Bruneval, Annalisa Angelini, Dylan V. M
American Journal of Transplantation.2020; 20(12): 3308. CrossRef

Reviews

A Review of Inflammatory Processes of the Breast with a Focus on Diagnosis in Core Biopsy Samples: Timothy M. D’Alfonso, Paula S. Ginter, Sandra J. Shin; J Pathol Transl Med. 2015;49(4):279-287. Published online June 22, 2015; DOI: https://doi.org/10.4132/jptm.2015.06.11

23,725 View
438 Download
29 Web of Science
40 Crossref

Abstract PDF

Inflammatory and reactive lesions of the breast are relatively uncommon among benign breast lesions and can be the source of an abnormality on imaging. Such lesions can simulate a malignant process, based on both clinical and radiographic findings, and core biopsy is often performed to rule out malignancy. Furthermore, some inflammatory processes can mimic carcinoma or other malignancy microscopically, and vice versa. Diagnostic difficulty may arise due to the small and fragmented sample of a core biopsy. This review will focus on the pertinent clinical, radiographic, and histopathologic features of the more commonly encountered inflammatory lesions of the breast that can be characterized in a core biopsy sample. These include fat necrosis, mammary duct ectasia, granulomatous lobular mastitis, diabetic mastopathy, and abscess. The microscopic differential diagnoses for these lesions when seen in a core biopsy sample will be discussed.

Citations

Citations to this article as recorded by

Evaluation of clinical profiles, imaging findings and antituberculosis treatment outcome in granulomatous mastitis: An Indian scenario
R. Mithen, R.R. Mahin Nallasivam, Dhanasekar Thangaswamy, T. Mohanapriya
Indian Journal of Tuberculosis.2024; 71(2): 163. CrossRef
Granulomatous mastitis: A diagnostic challenge—3 year single institutional experience
Adil Aziz Khan, Sana Ahuja, Sufian Zaheer, Charanjeet Ahluwalia, Mukul Singh, Sachin Kolte, Sunil Ranga
Diagnostic Cytopathology.2024; 52(1): 50. CrossRef
Efficacy and safety of rifampicin-based triple therapy for non-puerperal mastitis: A single-arm, open-label, prospective clinical trial
Fei Zhou, Huanjie Li, Fei Wang, Liyuan Liu, Lixiang Yu, Yujuan Xiang, Chao Zheng, Shuya Huang, Zhigang Yu
International Journal of Infectious Diseases.2024; 140: 25. CrossRef
Periductal Mastitis, a Disease with Distinct Clinicopathological Features from Granulomatous Lobular Mastitis
Fei Zhou, Liyuan Liu, Fei Wang, Lixiang Yu, Yujuan Xiang, Chao Zheng, Shuya Huang, Zhen Yang, Zhigang Yu
Journal of Inflammation Research.2024; Volume 17: 3815. CrossRef
MASTITE GRANULOMATOSA E O DIFÍCIL MANEJO DA DOENÇA: UMA REVISÃO SISTEMÁTICA DE LITERATURA
Samara Alves Messias Viana, Laís Barbosa de Azevedo Bulsoni
REVISTA FOCO.2024; 17(6): e5136. CrossRef
Autoimmune Mastitis in a Patient with Behcet’s Syndrome: A Case Report with Rapid Changes in Radiologic Features and Characteristic Pathologic Findings
Yun Hwa Chang, Suk Jin Park, Joo Heon Kim
Journal of the Korean Society of Radiology.2024;[Epub] CrossRef
Possibilities of MRI in the differential diagnosis of non-lactative mastitis and cancer
S. V. Serebryakova, T. A. Shumakova, E. A. Yukhno, O. B. Safronova, A. L. Serebryakov
Medical Visualization.2023; 27(2): 36. CrossRef
Idiopathic granulomatous mastitis in seventy seven-female patients: Management, follow up of an overlooked immune-mediated disease, and review of literature
Amira A. Shahin, Emad Khallaf, Lamiaa A. Salaheldin, Somia A.M. Soliman, Yosra S. Rezk, Marwa H. Niazy
The Egyptian Rheumatologist.2023; 45(3): 183. CrossRef
Increased breast cancer mortality due to treatment delay and needle biopsy type: a retrospective analysis of SEER-medicare
Rashmi Pathak, Macall Leslie, Priya Dondapati, Rachel Davis, Kenichi Tanaka, Elizabeth Jett, Inna Chervoneva, Takemi Tanaka
Breast Cancer.2023; 30(4): 627. CrossRef
Clinical characteristics and therapeutic strategy of granulomatous mastitis accompanied by Corynebacterium kroppenstedtii: a retrospective cohort study
ShunBo Li, Qian Huang, PeiPei Song, XiaoRong Han, ZeYu Liu, Lin Zhou, Ping Ning
BMC Women's Health.2023;[Epub] CrossRef
Nano Uncaria gambir as Chemopreventive Agent Against Breast Cancer
Andika Pramudya Wardana, Nanik Siti Aminah, Alfinda Novi Kristanti, Mochamad Zakki Fahmi, Haninda Iffatuz Zahrah, W Widiyastuti, Hendrix Abdul Ajiz, Ummi Zubaidah, Priangga Adi Wiratama, Yoshiaki Takaya
International Journal of Nanomedicine.2023; Volume 18: 4471. CrossRef
Inflammatory Lesions of the Breast
Gulisa Turashvili, Xiaoxian Li
Archives of Pathology & Laboratory Medicine.2023; 147(10): 1133. CrossRef
Case Report: Open biopsy and drainage for breast abscess caused by cholesterol granuloma is beneficial rather than breast core biopsy
Freda Halim, Ricarhdo Valentino Hanafi, Eka Julianta Wahjoepramono
F1000Research.2022; 11: 511. CrossRef
Inflammatory granulomatous mastitis caused by Corynebacterium kroppenstedtii: A clinical challenge
I.M. Brouwer de Koning, A. Lemson, N.H.M. Renders, M. Bessems, P.T.G.A. Nooijen, W.A. Draaisma, K. Bosscha
Clinical Infection in Practice.2022; 15: 100147. CrossRef
Case Report: Open biopsy and drainage for breast abscess caused by cholesterol granuloma is beneficial rather than breast core biopsy
Freda Halim, Ricarhdo Valentino Hanafi, Eka Julianta Wahjoepramono
F1000Research.2022; 11: 511. CrossRef
Case Report: Open biopsy and drainage for breast abscess caused by cholesterol granuloma is beneficial rather than breast core biopsy
Freda Halim, Ricarhdo Valentino Hanafi, Eka Julianta Wahjoepramono
F1000Research.2022; 11: 511. CrossRef
Exocrine gland structure-function relationships
Sameed Khan, Sarah Fitch, Sarah Knox, Ripla Arora
Development.2022;[Epub] CrossRef
Precision pathology as applied to breast core needle biopsy evaluation: implications for management
Laura C. Collins
Modern Pathology.2021; 34: 48. CrossRef
Granulomatous mastitis, watch and wait is a good option
Gökay Çetinkaya, Ramazan Kozan, Ahmet Cihangir Emral, Ekmel Tezel
Irish Journal of Medical Science (1971 -).2021; 190(3): 1117. CrossRef
Mammary duct ectasia in adult females; risk factors for the disease, a case control study
Ayad Ahmad Mohammed
Annals of Medicine and Surgery.2021; 62: 140. CrossRef
Palpable Lumps after Mastectomy: Radiologic-Pathologic Review of Benign and Malignant Masses
Rend Al-Khalili, Ali Alzeer, Giang-Kimthi Nguyen, Erin P. Crane, Judy H. Song, Janice L. Jeon, Michael Nellamattathil, Erini V. Makariou, Victoria L. Mango
RadioGraphics.2021; 41(4): E967. CrossRef
A case report of TB versus idiopathic granulomatous mastitis with erythema nodosum, reactive arthritis, cough, and headache
Fatma Ben Abid, Hussam Abdel Rahman S. Al Soub
The Aging Male.2020; 23(5): 411. CrossRef
Imaging features of granulomatous mastitis in 36 patients with new sonographic signs
Afsaneh Alikhassi, Fahimeh Azizi, Fereshteh Ensani
Journal of Ultrasound.2020; 23(1): 61. CrossRef
Secreciones mamarias
C. Mathelin, N. Weingertner, M. Lodi, S. Molière
EMC - Ginecología-Obstetricia.2020; 56(1): 1. CrossRef
Mastitis in Autoimmune Diseases: Review of the Literature, Diagnostic Pathway, and Pathophysiological Key Players
Radjiv Goulabchand, Assia Hafidi, Philippe Van de Perre, Ingrid Millet, Alexandre Thibault Jacques Maria, Jacques Morel, Alain Le Quellec, Hélène Perrochia, Philippe Guilpain
Journal of Clinical Medicine.2020; 9(4): 958. CrossRef
Factors associated with treatment duration and recurrence rate of complicated mastitis
Ming-Jui Tsai, Wei-Chia Huang, Jann-Tay Wang, Ming-Yang Wang, Yi-Hsuan Lee, Shu-Wen Lin, Sung-Ching Pan, Shan-Chwen Chang
Journal of Microbiology, Immunology and Infection.2020; 53(6): 875. CrossRef
Cystic neutrophilic granulomatous mastitis: an update
Jessie M Wu, Gulisa Turashvili
Journal of Clinical Pathology.2020; 73(8): 445. CrossRef
Coryneform Bacteria in Granulomatous Lobular Mastitis: Morphological Diagnosis in Breast Biopsies
David Oddó, Angeles Stefanelli, Alejandra Villarroel, Gonzalo P. Méndez
International Journal of Surgical Pathology.2019; 27(4): 380. CrossRef
Sonographic features of inflammatory conditions of the breast
Alice Febery, Ian Bennett
Australasian Journal of Ultrasound in Medicine.2019; 22(3): 165. CrossRef
Etiología de la mastitis crónica: propuesta de secuencia diagnóstica
A. García-Vilanova Comas, J. Galbis Caravajal, V. Sabater Marco, C.A. Fuster Diana, F. Villalba Ferrer, M. Bruna Esteban, C. Zaragozá Fernández
Clínica e Investigación en Ginecología y Obstetricia.2018; 45(3): 98. CrossRef
Idiopathic Granulomatous Mastitis: Manifestations at Multimodality Imaging and Pitfalls
Cedric W. Pluguez-Turull, Jennifer E. Nanyes, Cristina J. Quintero, Hamza Alizai, Daniel D. Mais, Kenneth A. Kist, Nella C. Dornbluth
RadioGraphics.2018; 38(2): 330. CrossRef
Corynebacterium kroppenstedtii in granulomatous mastitis: Analysis of formalin‐fixed, paraffin‐embedded biopsy specimens by immunostaining using low‐specificity bacterial antisera and real‐time polymerase chain reaction
Mari Fujii, Yasuyoshi Mizutani, Takahiko Sakuma, Kouichiro Tagami, Kiichiro Okamoto, Yasushi Kuno, Michihiko Harada, Koichi Kubouchi, Yutaka Tsutsumi
Pathology International.2018; 68(7): 409. CrossRef
Idiopathic Granulomatous Mastitis Presenting as a Breast Pseudotumor: Case Reports with Review of the Literature
Nour Abdul Halim, Imad Uthman, Rayan Rammal, Hazem I. Assi
Case Reports in Rheumatology.2018; 2018: 1. CrossRef
UTILITY OF FNAC IN UNCOMMON INFLAMMATORY AND REACTIVE LESIONS OF BREAST: AN UNSUSPECTED CLINICAL SCENARIO
Rallapalli Rajyalakshmi, Mohammad Akhtar, Rani Vijaya Bhaskar, Kada Venkataramana, Guttikonda Nageswararao, Rayachoti Sridhar
Journal of Evidence Based Medicine and Healthcare.2018; 5(44): 3070. CrossRef
Inflammatory breast disease: A pictorial essay with radiological‐pathological correlation
Rusiru P Gunawardena, Deepika Gunawardena, Cecily Metcalf, Donna Taylor, Liz Wylie
Journal of Medical Imaging and Radiation Oncology.2017; 61(1): 70. CrossRef
Cystic neutrophilic granulomatous mastitis associated with Corynebacterium including Corynebacterium kroppenstedtii
Kate J. Johnstone, Jennifer Robson, Sarah G. Cherian, Jenny Wan Sai Cheong, Kris Kerr, Judith F. Bligh
Pathology.2017; 49(4): 405. CrossRef
Is contrast‐enhanced spectral mammography (CESM) helpful in differentiating diabetic mastopathy from breast carcinoma?
María del Mar Travieso Aja, Gloria Santana López, Mario Rodríguez Rodríguez, Octavio P Luzardo
Journal of Medical Imaging and Radiation Oncology.2016; 60(5): 639. CrossRef
Lesiones inflamatorias mamarias benignas
Andrés García-Vilanova Comas, Vicente Sabater Marco, Carlos Fuster Diana, Francisco Villalba Ferrer, José Medrano González, Ramón Gómez Contreras
Revista Española de Patología.2016; 49(3): 169. CrossRef
Granulomatous lobular mastitis
Fei Zhou, Li‐Xiang Yu, Zhong‐Bing Ma, Zhi‐Gang Yu
Chronic Diseases and Translational Medicine.2016; 2(1): 17. CrossRef
Idiopathic Granulomatous Mastitis: Cytologic and Histologic Study of 65 Egyptian Patients
Thanaa El A. Helal, Lobna S. Shash, Somaia A. Saad El-Din, Sally M. Saber
Acta Cytologica.2016; 60(5): 438. CrossRef

Advances in the Endoscopic Assessment of Inflammatory Bowel Diseases: Cooperation between Endoscopic and Pathologic Evaluations: Jae Hee Cheon; J Pathol Transl Med. 2015;49(3):209-217. Published online May 15, 2015; DOI: https://doi.org/10.4132/jptm.2015.04.09

12,015 View
95 Download
5 Web of Science
5 Crossref

Abstract PDF

Endoscopic assessment has a crucial role in the management of inflammatory bowel disease (IBD). It is particularly useful for the assessment of IBD disease extension, severity, and neoplasia surveillance. Recent advances in endoscopic imaging techniques have been revolutionized over the past decades, progressing from conventional white light endoscopy to novel endoscopic techniques using molecular probes or electronic filter technologies. These new technologies allow for visualization of the mucosa in detail and monitor for inflammation/dysplasia at the cellular or sub-cellular level. These techniques may enable us to alter the IBD surveillance paradigm from four quadrant random biopsy to targeted biopsy and diagnosis. High definition endoscopy and dye-based chromoendoscopy can improve the detection rate of dysplasia and evaluate inflammatory changes with better visualization. Dye-less chromoendoscopy, including narrow band imaging, iScan, and autofluorescence imaging can also enhance surveillance in comparison to white light endoscopy with optical or electronic filter technologies. Moreover, confocal laser endomicroscopy or endocytoscopy have can achieve real-time histology evaluation in vivo and have greater accuracy in comparison with histology. These new technologies could be combined with standard endoscopy or further histologic confirmation in patients with IBD. This review offers an evidence-based overview of new endoscopic techniques in patients with IBD.

Citations

Citations to this article as recorded by

Moxifloxacin promotes two-photon microscopic imaging for discriminating different stages of DSS-induced colitis on mice
Yingtong Chen, Xiaoyi Xu, Min Wang, Xiang Wang, Yan Wang, Yong Zhang, Jin Huang, Yuwen Tao, Wentao Fan, Lili Zhao, Li Liu, Zhining Fan
Photodiagnosis and Photodynamic Therapy.2024; 48: 104220. CrossRef
Colorectal cancer in inflammatory bowel disease: review of the evidence
D. S. Keller, A. Windsor, R. Cohen, M. Chand
Techniques in Coloproctology.2019; 23(1): 3. CrossRef
Probe-based confocal laser endomicroscopy in the differential diagnosis of inflammatory bowel diseases: a case series
Jung Won Park, Tae Il Kim, Jae Hee Cheon
Intestinal Research.2018; 16(4): 641. CrossRef
How to Assess and Document Endoscopies in IBD Patients by Including Standard Scoring Systems
Anna M. Buchner, Gary R. Lichtenstein
Inflammatory Bowel Diseases.2016; 22(4): 1010. CrossRef
Nodular lymphoid hyperplasia: A marker of low-grade inflammation in irritable bowel syndrome?
Anna Chiara Piscaglia, Lucrezia Laterza, Valentina Cesario, Viviana Gerardi, Rosario Landi, Loris Riccardo Lopetuso, Giovanni Calò, Giovanna Fabbretti, Massimo Brisigotti, Maria Loredana Stefanelli, Antonio Gasbarrini
World Journal of Gastroenterology.2016; 22(46): 10198. CrossRef

Case Study

Follicular Dendritic Cell Sarcoma of the Inflammatory Pseudotumor-like Variant Presenting as a Colonic Polyp: Shien-Tung Pan, Chih-Yuan Cheng, Nie-Sue Lee, Peir-In Liang, Shih-Sung Chuang; Korean J Pathol. 2014;48(2):140-145. Published online April 28, 2014; DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.2.140

9,145 View
98 Download
32 Crossref

Abstract PDF

Follicular dendritic cell (FDC) sarcoma is rare and is classified either as conventional type or inflammatory pseudotumor (IPT)-like variant. Extranodal presentation is uncommon and nearly all gastrointestinal FDC tumors are of the conventional type. IPT-like variant tumors occur almost exclusively in the liver and spleen and are consistently associated with Epstein-Barr virus (EBV). Here we report the case of a 78-year-old woman with an IPT-like FDC sarcoma presenting as a pedunculated colonic polyp. Histologically, scanty atypical ovoid to spindle cells were mixed with a background of florid lymphoplasmacytic infiltrate, which led to an initial misdiagnosis of pseudolymphoma. These atypical cells expressed CD21, CD23, CD35, and D2-40, and were positive for EBV by in situ hybridization, confirming the diagnosis. The patient was free of disease five months after polypectomy without adjuvant therapy. Although extremely rare, the differential diagnosis for colonic polyp should include FDC sarcoma to avoid an erroneous diagnosis. A review of the 24 cases of IPT-like FDC sarcoma reported in the literature reveal that this tumor occurs predominantly in females with a predilection for liver and spleen, and has a strong association with EBV.

Citations

Citations to this article as recorded by

What is new in the 5th edition of the World Health Organization classification of mature B and T/NK cell tumors and stromal neoplasms?
Ayoma D. Attygalle, John K. C. Chan, Sarah E. Coupland, Ming-Qing Du, Judith A. Ferry, Daphne de Jong, Dita Gratzinger, Megan S. Lim, Alina Nicolae, German Ott, Andreas Rosenwald, Anna Schuh, Reiner Siebert
Journal of Hematopathology.2024; 17(2): 71. CrossRef
Pathologic characteristics of histiocytic and dendritic cell neoplasms
Sun Och Yoon
Blood Research.2024;[Epub] CrossRef
Epstein-barr virus (EBV)-positive inflammatory pseudotumor-like follicular dendritic cell sarcoma (IPT-like FDCS) presenting as thrombocytopenia: A case report and literature review
Jiawei Jin, Xiaolong Zhu, Yi Wan, Yang Shi
Heliyon.2024; 10(12): e32997. CrossRef
EBV-positive inflammatory follicular dendritic cell sarcoma of the colon with clonal immunoglobulin gene rearrangement: A case report and literature review
Xia Xu, Xiuzhen Li, Qun Deng, Kaihang Yu, Jinfan Li
Heliyon.2024; 10(11): e31947. CrossRef
Challenges in the Diagnosis of Epstein-Barr Virus-positive Inflammatory Follicular Dendritic Cell Sarcoma
Yan Li, Xia Yang, Lili Tao, Weimei Zeng, Min Zuo, Shuo Li, Liyan Wu, Yanshong Lin, Ziying Zhang, Jingping Yun, Yuhua Huang
American Journal of Surgical Pathology.2023; 47(4): 476. CrossRef
Epstein-Barr Virus-Positive Inflammatory Follicular Dendritic Cell Sarcoma Presenting as a Colonic Polyp: Report of a Case with a Literature Review
Jiahui Hu, Dongdong Huang, Chengfu Xu, Yi Chen, Han Ma, Zhe Shen
Medicina.2023; 59(7): 1341. CrossRef
A Clinicopathology Review and Update of Epstein–Barr Virus-Associated Mesenchymal Tumors
Oswald Zhao Jian Lee, Noorjehan Omar, Joshua K. Tay, Victor Kwan Min Lee
Cancers.2023; 15(23): 5563. CrossRef
Granulomatous splenic mass with necrosis revealing an EBV-positive inflammatory follicular dendritic cell sarcoma
Irena Antonia Ungureanu, Renato Micelli Lupinacci, Marie Parrens, Jean-François Emile
Journal of Surgical Case Reports.2022;[Epub] CrossRef
Case report: Hepatic inflammatory pseudotumor-like follicular dendritic cell sarcoma: A rare case and minireview of the literature
Fan Ding, Chao Wang, Chi Xu, Hui Tang
Frontiers in Medicine.2022;[Epub] CrossRef
Follicular dendritic cell sarcoma of gastrointestinal tract with two emerging distinct subtypes: a case report and systemic review
Hongxing Gui, Jigisha Chaudhari, Rifat Mannan
Diagnostic Pathology.2022;[Epub] CrossRef
Surgical treatment of liver inflammatory pseudotumor-like follicular dendritic cell sarcoma: A case report
Li-Yue Fu, Jiu-Liang Jiang, Meng Liu, Jun-Jun Li, Kai-Ping Liu, Hai-Tao Zhu
World Journal of Gastrointestinal Oncology.2022; 14(11): 2288. CrossRef
Inflammatory pseudotumor-like follicular/fibroblastic dendritic cell sarcoma: focus on immunohistochemical profile and association with Epstein-Barr virus
Francesca Pagliuca, Andrea Ronchi, Annamaria Auricchio, Eva Lieto, Renato Franco
Infectious Agents and Cancer.2022;[Epub] CrossRef
Recent Advances in Digestive Tract Tumors: Updates From the 5th Edition of the World Health Organization “Blue Book”
Raul S. Gonzalez, Anwar Raza, Robert Propst, Oyedele Adeyi, Justin Bateman, Sabrina C. Sopha, Janet Shaw, Aaron Auerbach
Archives of Pathology & Laboratory Medicine.2021; 145(5): 607. CrossRef
Hepatic inflammatory pseudotumor-like follicular dendritic cell tumor: a case report
Ana Daniela Pascariu, Andreea Ioana Neagu, Andrei Valentin Neagu, Alexandru Băjenaru, Cezar Iulian Bețianu
Journal of Medical Case Reports.2021;[Epub] CrossRef
Inflammatory pseudotumor-like follicular dendritic cell sarcoma: Literature review of 67 cases
Hao Wu, Peng Liu, Xiao-Ran Xie, Jing-Shu Chi, Huan Li, Can-Xia Xu
World Journal of Meta-Analysis.2021; 9(1): 1. CrossRef
New Clinicopathologic Scenarios of EBV+ Inflammatory Follicular Dendritic Cell Sarcoma
Xiang-Nan Jiang, Yan Zhang, Tian Xue, Jie-Yu Chen, Alex C.L. Chan, Wah Cheuk, John K.C. Chan, Xiao-Qiu Li
American Journal of Surgical Pathology.2021; 45(6): 765. CrossRef
Select Epstein-Barr Virus–Associated Digestive Tract Lesions for the Practicing Pathologist
Zainab I. Alruwaii, Elizabeth A. Montgomery
Archives of Pathology & Laboratory Medicine.2021; 145(5): 562. CrossRef
Overview of Gastrointestinal Lymphoproliferative disorders✰
Aaron Auerbach, Nadine S. Aguilera
Seminars in Diagnostic Pathology.2021; 38(4): 1. CrossRef
Follicular dendritic cell sarcoma
Fabio Facchetti, Matteo Simbeni, Luisa Lorenzi
Pathologica.2021; 113(5): 316. CrossRef
Hepatic inflammatory pseudotumor-like follicular dendritic cell tumor with hepatic lymphoma history
Jiang Li, Hai-su Tao, Dong Chen, Zhi-yong Huang, Er-lei Zhang
Medicine.2021; 100(39): e27392. CrossRef
Clinicopathological characteristics of extranodal follicular dendritic cell sarcoma: A report of two cases
Xing Zhao, Dayong Sun, Gang Zhang
Oncology Letters.2021;[Epub] CrossRef
Inflammatory pseudotumour-like follicular dendritic cell tumour of the colon with plasmacytosis mimicking EBV-positive lymphoproliferative disorder
Ying-Ren Chen, Chi-Lin Lee, Yen-Chien Lee, Kung-Chao Chang
Pathology.2020; 52(4): 484. CrossRef
Beware the inflammatory cell-rich colonic polyp: a rare case of EBV-positive inflammatory pseudotumour-like follicular dendritic cell sarcoma with increased IgG4-positive plasma cells
Lynne Goh, Nan Zun Teo, Lai Mun Wang
Pathology.2020; 52(6): 713. CrossRef
Epstein–Barr virus‐positive inflammatory follicular dendritic cell sarcoma presenting as a solitary colonic mass: two rare cases and a literature review
Xiaokang Ke, Huihua He, Qingping Zhang, Jingping Yuan, Qilin Ao
Histopathology.2020; 77(5): 832. CrossRef
Inflammatory pseudotumor-like follicular dendritic cell sarcoma: A brief report of two cases
Bi-Xi Zhang, Zhi-Hong Chen, Yu Liu, Yuan-Jun Zeng, Yan-Chun Li
World Journal of Gastrointestinal Oncology.2019; 11(12): 1231. CrossRef
Epstein-Barr virus (EBV)–associated lymphoid proliferations, a 2018 update
Sherif A. Rezk, Xiaohui Zhao, Lawrence M. Weiss
Human Pathology.2018; 79: 18. CrossRef
A Rare Case of Epstein-Barr Virus Negative Inflammatory Pseudotumor-like Follicular Dendritic Cell Sarcoma Presenting as a Solitary Colonic Mass in a 53-Year-Old Woman; Case Report and Review of Literature
Rossana Kazemimood, Farid Saei Hamedani, Asma Sharif, Sujata Gaitonde, Elizabeth Wiley, Pier Cristoforo Giulianotti, John Vincent Groth
Applied Immunohistochemistry & Molecular Morphology.2017; 25(5): e30. CrossRef
A Case of Inflammatory Pseudotumor-like Follicular Dendritic Cell Sarcoma of the Lymph Node in the Small Bowel Mesentery Accompanied by Myasthenia Gravis
Daichi KITAGUCHI, Katsuji HISAKURA, Taiki SATO, Masanao KURATA, Tatsuya ODA, Nobuhiro OHKOHCHI
Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2017; 78(3): 527. CrossRef
Clinicopathological features of inflammatory pseudotumour‐like follicular dendritic cell tumour of the abdomen
Yanyang Chen, Huijuan Shi, Hui Li, Tiantian Zhen, Anjia Han
Histopathology.2016; 68(6): 858. CrossRef
A Rare Case of Follicular Dendritic Cell Sarcoma with Pseudochylous Effusion and Review of Literature From India
Kamal Kant Sahu, Gaurav Prakash, Sandeep Rao, Amanjit Bal, Pankaj Malhotra, Jasmina Ahluwalia, Rakesh K. Vashistha
Indian Journal of Hematology and Blood Transfusion.2015; 31(2): 307. CrossRef
Epstein-Barr virus–associated inflammatory pseudotumor presenting as a colonic mass
Shunyou Gong, Iwona Auer, Rajan Duggal, Stefania Pittaluga, Mark Raffeld, Elaine S. Jaffe
Human Pathology.2015; 46(12): 1956. CrossRef
Response of follicular dendritic cell sarcoma to gemcitabine and docetaxel: report of two cases and literature review
Robert M Conry
Clinical Sarcoma Research.2014;[Epub] CrossRef

Original Article

Inflammatory Pseudotumor of the Urinary Bladder: An Immunohistochemical and Ultrastructural Study.: Seung Sam Paik, Joo Seob Keum, Moon Hyang Park, Jung Dal Park; Korean J Pathol. 1996;30(5):447-452.

1,585 View
17 Download

Abstract PDF: Inflammatory pseudotumor of the urinary bladder is an unusual, benign mesenchymal proliferative lesion of the submucosal stroma easily mistaken for a malignant neoplasm clinically and histologically. We present a case and describe the clinical presentation and radiologic, histologic, histochemical, immunohistochemical, and ultrastructural findings. A 23-year old patient presented with sudden onset of gross painless hematuria for 3 months. There was no previous instrumentation or surgery involving the genitourinary tract. Cystoscopy revealed a large polypoid and ulcerated bladder mass. The lesion consisted of plump spindle shaped, fibroblast-like cells embedded in a myxoid stroma. Mitotic figures were negligible and the lesion showed encroachment on the superficial muscle bundles. The spindle cells were immunoreactive for vimentin and muscle specific actin. Immunohistochemical and ultrastructural findings revealed the fibroblastic-myofibroblastic nature of this lesion. Complete surgical excision by partial cystectomy was successful in eradicating the lesion. The findings are described with a discussion of the pathogenesis and review of the literature.

Case Reports

Inflammatory Myofibroblastic Tumor in Posterior Mediastinum.: Seung Sam Paik, Seok Hoon Jeon, Se Jin Jang, Moon Hyang Park, Jung Dal Lee; Korean J Pathol. 1997;31(1):63-67.

1,693 View
22 Download

Abstract PDF: Inflammatory myofibroblastic tumor(IMT) or inflammatory pseudotumor is a rare, solid tumor that most often affects children. This tumor is characterized by a spindle cell proliferation admixed with a variety of inflammatory cells. Although it has disputed nosology, a distinctive fibroinflammatory and even pseudosarcomatous appearance have been well appreciated. Herein, we report a case of IMT in the posterior mediastinum in a 19-year-old girl with clinical findings. The immunohistochemical and ultrastructural studies on the tumor cells are reported, and their distinctive characteristics are discussed in details.

Inflammatory Pseudotumor of the Kidney.: Hwa Eun Oh, Jeong Seok Moon, Sung Jin Cho, Nam Hee Won; Korean J Pathol. 1997;31(6):592-594.

1,650 View
12 Download

Abstract PDF: Inflammatory pseudotumor, originally described in the lung, is a relatively rare tumor-like lesion that occurs in various organs and tissues. It is usually well demarcated from the surrounding tissue, however it can be unfortunately resected as a malignant tumor. A few inflammtory pseudotumor in the kidney have been reported in English literature, but there have been no reports in Korea. We report a case with inflammatory pseudotumor of the kidney. A 48 year old woman had an intermittent flank pain on the right side. An ultrasonographic study suggested a renal cell carcinoma and a nephrectomy was done. Grossly, there were two separate masses with a well demarcated yellowish appearance, measuring 2.3 cm and 1.3 cm in diameter, respectively. Histologically, they were composed of smooth muscle actin positive spindle cells and a large number of foamy histiocytes, lymphocytes, and plasma cells in the fibrotic backgound.

Original Articles

Cytomegalovirus Infection in Idiopathic Inflammatory Bowel Disease: Clinicopathologic Analysis of 6 Cases.: Won Ae Lee, Hye Sung Hahn, Woo Ho Kim, Yong Il Kim; Korean J Pathol. 1998;32(2):125-130.

1,778 View
12 Download

Abstract PDF: Cytomegalovirus (CMV) infection is an uncommon association with idiopathic inflammatory bowel disease (IBD) often leading to a variety of serious complications. A total of 41 resected cases of IBD were examined to elucidate the pathologic features of intestinal CMV infection which was assessed by histologic examination and confirmed by immunohistochemistry with CMV antibody. Six cases were positve for CMV antibody; five cases in 19 ulcerative colitis (UC, 26.3%) and one case in 22 Crohn's disease (CD, 4.5%). Of 7 cases of the steroid-treated UC group, five cases were superinfected with CMV (71.4%) but none in 12 cases of the steroid-untreated UC group. All of the five CMV-positive cases in UC showed deep ulceration and transmural inflammation, while none of 10 UC cases without above features were CMV positive. Fibrinoid necrosis and thrombi were found in 83.3% of the CMV infected group, while none in the CMV-negative group of UC cases (p=0.01). We conclude that IBD, particularly UC, is susceptible to the CMV infection when steroid hormone is administered, and that deep colonic ulceration, transmural inflammation and fibrinoid necrosis of vasculature may suggest superinfection of CMV in UC patients. It seems that deep colonic ulceration may be the consequence of an ischemic change following vascular luminal occlusion or vasculitis by CMV infection.

Immunohistochemical Findings in 10 Cases of Inflammatory Myofibroblastic Tumor.: Soo Jin Jung, Mi Seon Kang, Chang Hoon Lee, Sook Hee Hong, Hye Kyoung Yoon; Korean J Pathol. 1999;33(9):717-722.

1,876 View
19 Download

Abstract PDF: A wide range of denomination has been used for inflammatory myofibroblastic tumor (IMT). IMT is not entirely homogeneous, even though it shows some overlapping histologic features such as haphazard proliferation of spindle cell and polymorphic chronic inflammatory cell infiltraion. The spindle cell is considered to be of myofibroblastic origin but follicular dendritic cell origin was reported recently. IMT is known as nonneoplastic, aberrant inflammatory response. However, IMT could show local invasion, recurrence, vascular invasion, and malignant transformation, and clonal characteristics and aneuploidy of IMT support the hypothesis that IMT may be a neoplastic process. In order to define the nature of spindle cell of IMT, immunohistochemical stains for smooth muscle actin (SMA), vimentin (VMT), lysozyme, S-100 protein, cytokeratin, CD21 were done. Additional immunohistochemical stains for MIB-1 for proliferating activity and LMP (latent membrane protein) for Epstein-Barr virus (EBV) were done. IMTs were composed of each 2 cases from lung, liver and lymph node and one case from common bile duct, maxillary sinus, bladder and thigh, and were histologically subclassified according to Coffin et al. Nine cases (90%) were positive for SMA and VMT, but no correlation between SMA and VMT immunoreactivity and histologic types was identified. Five cases (50%) were positive for lysozyme and S-100 protein, and histologic type III was negative for lysozyme and S-100 protein, and immunoreactivity for S-100 protein was different according to the histologic subtypes. All 11 cases were negative for CD21 and EBV LMP. MIB-1 labelling index was less than 1% in all cases. In summary, the spindle cell is regarded as myofibroblastic origin rather than follicular dendritic cell origin. Relationship with EBV is not clear, and negligible MIB-1 reaction suggests that IMT might have a good prognosis.

Case Report

Inflammatory Myofibroblastic Tumor of the Mesentery: A case report.: Sung Jig Lim, Gou Young Kim, Jae Hoon Park, Youn Wha Kim, Yong Koo Park, Ju Hie Lee, Moon Ho Yang; Korean J Pathol. 1999;33(9):729-732.

1,719 View
23 Download

Abstract PDF: Inflammatory myofibroblastic tumor or inflammatory pseudotumor is characterized by spindle cell proliferation with inflammatory cell infiltration, predominantly plasma cells and lymphocytes. We have experienced a case of inflammatory myofibroblastic tumor of the mesentery in a 57-year-old male patient with intermittent abdominal pain. On computer tomography, a well demarcated mass was seen in the mesenteric side of the ascending colon. Right hemicolectomy was performed under the impression of the metastatic tumor of lymph nodes. Grossly, a rather well-circumscribed gray white mass was noted in the mesentery of the ascending colon. Microscopically, the lesion consisted of plump spindle cells and accompanying inflammatory cellular infiltrates. The spindle cells were positive for vimentin.

First
Prev
Page of 3
Next
Last

Search