Journal of Pathology and Translational Medicine

Volume 48(2); April 2014

Review

Current Concepts in Primary Effusion Lymphoma and Other Effusion-Based Lymphomas: Yoonjung Kim, Chan Jeong Park, Jin Roh, Jooryung Huh; Korean J Pathol. 2014;48(2):81-90. Published online April 28, 2014; DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.2.81

13,156 View
162 Download
29 Crossref

Primary effusion lymphoma (PEL) is a human herpes virus 8 (HHV8)-positive large B-cell neoplasm that presents as an effusion with no detectable tumor in individuals with human immunodeficiency virus infection or other immune deficiencies. PEL is an aggressive neoplasm with a poor prognosis. PEL cells show diverse morphologies, ranging from immunoblastic or plasmablastic to anaplastic. The immunophenotype of PEL is distinct, but its lineage can be misdiagnosed if not assessed thoroughly. PEL cells usually express CD45, lack B- and T-cell-associated antigens, and characteristically express lymphocyte activation antigens and plasma cell-associated antigens. Diagnosis of PEL often requires the demonstration of a B-cell genotype. HHV8 must be detected in cells to diagnose PEL. In most cases, PEL cells also harbor the Epstein-Barr virus (EBV) genome. Similar conditions associated with HHV8 but not effusion-based are called "extracavitary PELs." PELs should be differentiated from HHV8-negative, EBV-positive, body cavity-based lymphomas in patients with long-standing chronic inflammation; the latter can occur in tuberculous pleuritis, artificial pneumothorax, chronic liver disease and various other conditions. Despite their morphological similarity, these various lymphomas require different therapeutic strategies and have different prognostic implications. Correct diagnosis is essential to manage and predict the outcome of patients with PEL and related disorders.

Citations

Citations to this article as recorded by

Update: The molecular spectrum of virus-associated high-grade B-cell non-Hodgkin lymphomas
H. Witte, A. Künstner, N. Gebauer
Blood Reviews.2024; 65: 101172. CrossRef
Oncolytic strategy using new bifunctional HDACs/BRD4 inhibitors against virus-associated lymphomas
Jungang Chen, Zhengyu Wang, Tran Phuc, Zhigang Xu, Donglin Yang, Zhengzhu Chen, Zhen Lin, Samantha Kendrick, Lu Dai, Hong-yu Li, Zhiqiang Qin, Michael Lagunoff
PLOS Pathogens.2023; 19(1): e1011089. CrossRef
Primary Effusion Lymphoma: A Timely Review on the Association with HIV, HHV8, and EBV
Chih-Yi Liu, Bo-Jung Chen, Shih-Sung Chuang
Diagnostics.2022; 12(3): 713. CrossRef
Lymphoproliferative disorder involving body fluid: diagnostic approaches and roles of ancillary studies
Jiwon Koh, Sun Ah Shin, Ji Ae Lee, Yoon Kyung Jeon
Journal of Pathology and Translational Medicine.2022; 56(4): 173. CrossRef
Clinical Characteristics and Management of Patients With Concomitant Liver Cirrhosis and Lymphoma: A Systematic Review
Jelena Jelicic, Thomas Stauffer Larsen, Annette Dam Fialla, Zoran Bukumiric, Bosko Andjelic
Clinical Lymphoma Myeloma and Leukemia.2022; 22(11): e981. CrossRef
HHV8-unrelated primary effusion lymphoma: Two case reports and a review of literature
Ryan W. Kendall, Ricky A. Thompson, Christopher P. Garwacki, Alan Z. Skarbnik
Current Problems in Cancer: Case Reports.2021; 4: 100087. CrossRef
Targeting Host Cellular Factors as a Strategy of Therapeutic Intervention for Herpesvirus Infections
Kumari Asha, Neelam Sharma-Walia
Frontiers in Cellular and Infection Microbiology.2021;[Epub] CrossRef
A Rare Case of Extracavitary Primary Effusion Lymphoma in the Bladder and Ureter
Jiankun Tong, Sana Jadallah, William H. Rodgers, Gabriel Jung, Malvina Fulman, Abhisek Swaika
Case Reports in Hematology.2020; 2020: 1. CrossRef
KSHV: Immune Modulation and Immunotherapy
Grant Broussard, Blossom Damania
Frontiers in Immunology.2020;[Epub] CrossRef
Role of Ki 67 Labelling Index as an Adjunct to Histopathological Diagnosis for Grading of CNS Tumours
Priyanka Rai, Chandni Krishnani, Goswami S. S.
Journal of Evolution of Medical and Dental Sciences.2020; 9(16): 1331. CrossRef
Brentuximab vedotin as frontline treatment for HIV-related extracavitary primary effusion lymphoma
Jose D. Sandoval-Sus, Amanda Brahim, Alina Khan, Barbara Raphael, Ali Ansari-Lari, Marco Ruiz
International Journal of Hematology.2019; 109(5): 622. CrossRef
High-dose Therapy and Autologous Hematopoietic Cell Transplantation as Consolidation Treatment for Primary Effusion Lymphoma
Abu-Sayeef Mirza, Bhagirathbhai R. Dholaria, Mohammad Hussaini, Sarah Mushtaq, Pedro Horna, Adharsh Ravindran, Ambuj Kumar, Ernesto Ayala, Mohamed A. Kharfan-Dabaja, Celeste Bello, Julio C. Chavez, Lubomir Sokol
Clinical Lymphoma Myeloma and Leukemia.2019; 19(9): e513. CrossRef
Remission of an HHV8-related extracavitary primary effusion lymphoma in an HIV-positive patient during antiretroviral treatment containing dolutegravir
Laura Campogiani, Carlotta Cerva, Gaetano Maffongelli, Elisabetta Teti, Livio Pupo, Sara Vaccarini, Maria Cantonetti, Alfredo Pennica, Massimo Andreoni, Loredana Sarmati
AIDS Research and Therapy.2019;[Epub] CrossRef
Primary Effusion Lymphoma in a Non-Human Immunodeficiency Virus Patient: A Case Report
Beum Jin Kim, Mi Sook Lee
Journal of the Korean Society of Radiology.2019; 80(4): 810. CrossRef
Pleural effusion in a human immunodeficiency virus‐infected patient
Rafael Martínez‐Girón, Santiago Martínez‐Torre
Cytopathology.2019; 30(6): 673. CrossRef
Case report of a primary effusion lymphoma successfully treated with oral valganciclovir after failing chemotherapy
Juan Marquet, Kyra Velazquez‐Kennedy, Sandra López, Amparo Benito, María‐Jesús Blanchard, Jose Antonio Garcia‐Vela
Hematological Oncology.2018; 36(1): 316. CrossRef
Primary effusion lymphoma in Taiwan shows two distinctive clinicopathological subtypes with rare human immunodeficiency virus association
Bo‐Jung Chen, Ran‐Ching Wang, Chung‐Han Ho, Chang‐Tsu Yuan, Wan‐Ting Huang, Sheau‐Fang Yang, Pin‐Pen Hsieh, Yun‐Chih Yung, Shih‐Yao Lin, Chen‐Fang Hsu, Ying‐Zhen Su, Chun‐Chi Kuo, Shih‐Sung Chuang
Histopathology.2018; 72(6): 930. CrossRef
Effusion‐based lymphoma with morphological regression but with clonal genetic features after aspiration
Meng‐Chen Tsai, Chun‐Chi Kuo, Ying‐Zhen Su, Yen‐Chuan Hsieh, Shih‐Sung Chuang
Diagnostic Cytopathology.2018; 46(8): 685. CrossRef
Biology and management of primary effusion lymphoma
Kazuyuki Shimada, Fumihiko Hayakawa, Hitoshi Kiyoi
Blood.2018; 132(18): 1879. CrossRef
EBV‐associated but HHV8‐unrelated double‐hit effusion‐based lymphoma
Bo‐Jung Chen, David Yen‐Ting Chen, Chun‐Chi Kuo, Shih‐Sung Chuang
Diagnostic Cytopathology.2017; 45(3): 257. CrossRef
HHV8/KSHV-Positive Lymphoproliferative Disorders and the Spectrum of Plasmablastic and Plasma Cell Neoplasms
Amy Chadburn, Jonathan Said, Dita Gratzinger, John K. C. Chan, Daphne de Jong, Elaine S. Jaffe, Yasodha Natkunam, John R. Goodlad
American Journal of Clinical Pathology.2017; 147(2): 171. CrossRef
Human immunodeficiency virus (HIV) and Epstein-Barr virus (EBV) related lymphomas, pathology view point
Ebru Linke-Serinsöz, Falko Fend, Leticia Quintanilla-Martinez
Seminars in Diagnostic Pathology.2017; 34(4): 352. CrossRef
Anticancer drug-loaded quantum dots engineered polymeric nanoparticles: Diagnosis/therapy combined approach
D. Belletti, G. Riva, M. Luppi, G. Tosi, F. Forni, M.A. Vandelli, B. Ruozi, F. Pederzoli
European Journal of Pharmaceutical Sciences.2017; 107: 230. CrossRef
CD20-negative diffuse large B cell lymphoma: a comprehensive analysis of 695 cases
Jing Li, Shu Zhao, Jingxuan Wang, Jingyu Chen, Wen Wen, Qingyuan Zhang
Tumor Biology.2016; 37(3): 3619. CrossRef
Co-infections and Pathogenesis of KSHV-Associated Malignancies
Suhani Thakker, Subhash C. Verma
Frontiers in Microbiology.2016;[Epub] CrossRef
Pathology of Extranodal Lymphoma
Emily Heckendorn, Aaron Auerbach
Radiologic Clinics of North America.2016; 54(4): 639. CrossRef
2015 update on the diagnosis and management of neoplastic pericardial disease
Chiara Lestuzzi, Massimiliano Berretta, Witold Tomkowski
Expert Review of Cardiovascular Therapy.2015; 13(4): 377. CrossRef
CD20-negative diffuse large B-cell lymphomas: biology and emerging therapeutic options
Jorge J Castillo, Julio C Chavez, Francisco J Hernandez-Ilizaliturri, Santiago Montes-Moreno
Expert Review of Hematology.2015; 8(3): 343. CrossRef
Primary Effusion Lymphoma: Cytological Diagnosis of a Rare Entity - Report of Two Cases in HIV-Uninfected Patients from a Single Institution
Marta Nicola, Monica Onorati, Chiara Luisa Bianchi, Giuseppe Pepe, Stefano Bellone, Franca Di Nuovo
Acta Cytologica.2015; 59(5): 425. CrossRef

Original Articles

Pleural Mesothelioma: An Institutional Experience of 66 Cases: Soomin Ahn, In Ho Choi, Joungho Han, Jhingook Kim, Myung-Ju Ahn; Korean J Pathol. 2014;48(2):91-99. Published online April 28, 2014; DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.2.91

8,892 View
80 Download
2 Crossref

Abstract PDF

Background

Malignant mesothelioma of the pleura is an aggressive tumor known to be associated with asbestos. Histological diagnosis of mesothelioma is challenging and is usually aided by immunohistochemical markers.

Methods

During an 18-year period (1995-2012), 66 patients with pleural mesothelioma were diagnosed at the Samsung Medical Center in Seoul. We reviewed hematoxylin and eosin and immunohistochemical slides of pleural mesothelioma and evaluated their pathological and clinical features.

Results

The male-to-female ratio was 1.75:1, and age of patients ranged from 28 to 80 years with an average age of 56.84 years. Twenty-two out of 66 patients underwent curative pneumonectomy. Follow-up data was available in 60 patients (90.9%), and 50 of them (83.3%) died from the disease. The average overall survival was 15.39 months. Histologically, the epithelioid type was the most common, followed by the sarcomatoid and the biphasic types. Epidemiologic information was not available in most cases, and only one patient was confirmed to have a history of asbestos exposure.

Conclusions

Malignant mesothelioma of the pleura is a fatal tumor, and the therapeutic benefit of pneumonectomy remains unproven. The combination of calretinin, Wilms tumor 1, HMBE-1, and thyroid transcription factor-1 may provide high diagnostic accuracy in diagnosing mesothelioma.

Citations

Citations to this article as recorded by

Expression of V-set immunoregulatory receptor in malignant mesothelioma
Yeon Seung Chung, Moonsik Kim, Yoon Jin Cha, Kyung A Kim, Hyo Sup Shim
Modern Pathology.2020; 33(2): 263. CrossRef
Is the pathology related to the amount of pleural thickening measured by thorax CT?
özgür katrancıoğlu, Tuba Sahinoglu, Kayhan Karakus, Ozan Kandemir, Semiha Urvay, Esra Aydın Karakaya, Nurkay Katrancioglu
Cumhuriyet Medical Journal.2018; 40(2): 157. CrossRef

KRAS Mutation Detection in Non-small Cell Lung Cancer Using a Peptide Nucleic Acid-Mediated Polymerase Chain Reaction Clamping Method and Comparative Validation with Next-Generation Sequencing: Boram Lee, Boin Lee, Gangmin Han, Mi Jung Kwon, Joungho Han, Yoon-La Choi; Korean J Pathol. 2014;48(2):100-107. Published online April 28, 2014; DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.2.100

12,455 View
99 Download
17 Crossref

Abstract PDF

Background

KRAS is one of commonly mutated genetic "drivers" in non-small cell lung cancers (NSCLCs). Recent studies indicate that patients with KRAS-mutated tumors do not benefit from adjuvant chemotherapy, so there is now a focus on targeting KRAS-mutated NSCLCs. A feasible mutation detection method is required in order to accurately test for KRAS status.

Methods

We compared direct Sanger sequencing and the peptide nucleic acid (PNA)-mediated polymerase chain reaction (PCR) clamping method in 134 NSCLCs and explored associations with clinicopathological factors. Next-generation sequencing (NGS) was used to validate the results of discordant cases. To increase the resolution of low-level somatic mutant molecules, PNA-mediated PCR clamping was used for mutant enrichment prior to NGS.

Results

Twenty-one (15.7%) cases were found to have the KRAS mutations using direct sequencing, with two additional cases by the PNA-mediated PCR clamping method. The frequencies of KRAS mutant alleles were 2% and 4%, respectively, using conventional NGS, increasing up to 90% and 89%, using mutant-enriched NGS. The KRAS mutation occurs more frequently in the tumors of smokers (p=.012) and in stage IV tumors (p=.032).

Conclusions

Direct sequencing can accurately detect mutations, but, it is not always possible to obtain a tumor sample with sufficient volume. The PNA-mediated PCR clamping can rapidly provide results with sufficient sensitivity.

Citations

Citations to this article as recorded by

KRAS mutated Non‐Small Lung Carcinoma: A Real World Context from the Indian subcontinent
Ullas Batra, Shrinidhi Nathany, Mansi Sharma, Amrith BP, Joslia T. Jose, Harkirat Singh, Sakshi Mattoo, Anurag Mehta
Cancer Medicine.2023; 12(3): 2869. CrossRef
Mechanism exploration and prognosis study of Astragali Radix-Spreading hedyotis herb for the treatment of lung adenocarcinoma based on bioinformatics approaches and molecular dynamics simulation
Junfeng Guo, Yuting Zhao, Xuanyu Wu, Ganggang Li, Yuwei Zhang, Yang Song, Quanyu Du
Frontiers in Chemistry.2023;[Epub] CrossRef
PEAC: An Ultrasensitive and Cost-Effective MRD Detection System in Non-small Cell Lung Cancer Using Plasma Specimen
Jianping Xu, Yue Pu, Rui Lin, Shanshan Xiao, Yingxue Fu, Tao Wang
Frontiers in Medicine.2022;[Epub] CrossRef
Potential applications of peptide nucleic acid in biomedical domain
Kshitij RB Singh, Parikipandla Sridevi, Ravindra Pratap Singh
Engineering Reports.2020;[Epub] CrossRef
A Highly Sensitive Next-Generation Sequencing-Based Genotyping Platform for EGFR Mutations in Plasma from Non-Small Cell Lung Cancer Patients
Jung-Young Shin, Jeong-Oh Kim, Mi-Ran Lee, Seo Ree Kim, Kyongmin Sarah Beck, Jin Hyoung Kang
Cancers.2020; 12(12): 3579. CrossRef
Association with PD-L1 Expression and Clinicopathological Features in 1000 Lung Cancers: A Large Single-Institution Study of Surgically Resected Lung Cancers with a High Prevalence of EGFR Mutation
Seung Eun Lee, Yu Jin Kim, Minjung Sung, Mi-Sook Lee, Joungho Han, Hong Kwan Kim, Yoon-La Choi
International Journal of Molecular Sciences.2019; 20(19): 4794. CrossRef
Peptide Nucleic Acid Clamping and Direct Sequencing in the Detection of Oncogenic Alterations in Lung Cancer: Systematic Review and Meta-Analysis
Jae-Uk Song, Jonghoo Lee
Yonsei Medical Journal.2018; 59(2): 211. CrossRef
Comparative analysis of Adam33 mutations in murine lung cancer cell lines by droplet digital PCR, real-time PCR and Insight Onco™ NGS
Soo-Jin Kim, Eunhee Kim, Kyung-Taek Rim
Molecular & Cellular Toxicology.2018; 14(2): 221. CrossRef
KRAS mutation analysis by next‐generation sequencing in endoscopic ultrasound‐guided sampling for solid liver masses
Hyun Jong Choi, Jong Ho Moon, Hee Kyung Kim, Yun Nah Lee, Tae Hoon Lee, Sang‐Woo Cha, Young Deok Cho, Sang‐Heum Park
Journal of Gastroenterology and Hepatology.2017; 32(1): 154. CrossRef
Molecular Testing of Lung Cancers
Hyo Sup Shim, Yoon-La Choi, Lucia Kim, Sunhee Chang, Wan-Seop Kim, Mee Sook Roh, Tae-Jung Kim, Seung Yeon Ha, Jin-Haeng Chung, Se Jin Jang, Geon Kook Lee
Journal of Pathology and Translational Medicine.2017; 51(3): 242. CrossRef
Peptide nucleic acids: Advanced tools for biomedical applications
Anjali Gupta, Anuradha Mishra, Nidhi Puri
Journal of Biotechnology.2017; 259: 148. CrossRef
Application of Peptide Nucleic Acid-based Assays Toward Detection of Somatic Mosaicism
Christopher S Hong, Chunzhang Yang, Zhengping Zhuang
Molecular Therapy - Nucleic Acids.2016; 5: e314. CrossRef
Detecting Primary KIT Mutations in Presurgical Plasma of Patients with Gastrointestinal Stromal Tumor
Guhyun Kang, Byeong Seok Sohn, Jung-Soo Pyo, Jung Yeon Kim, Boram Lee, Kyoung-Mee Kim
Molecular Diagnosis & Therapy.2016; 20(4): 347. CrossRef
Transformation to Small Cell Lung Cancer of Pulmonary Adenocarcinoma: Clinicopathologic Analysis of Six Cases
Soomin Ahn, Soo Hyun Hwang, Joungho Han, Yoon-La Choi, Se-Hoon Lee, Jin Seok Ahn, Keunchil Park, Myung-Ju Ahn, Woong-Yang Park
Journal of Pathology and Translational Medicine.2016; 50(4): 258. CrossRef
Clinicopathologic characteristics of EGFR, KRAS, and ALK alterations in 6,595 lung cancers
Boram Lee, Taebum Lee, Se-Hoon Lee, Yoon-La Choi, Joungho Han
Oncotarget.2016; 7(17): 23874. CrossRef
Detection of KIT and PDGFRA mutations in the plasma of patients with gastrointestinal stromal tumor
Guhyun Kang, Byung Noe Bae, Byeong Seok Sohn, Jung-Soo Pyo, Gu Hyum Kang, Kyoung-Mee Kim
Targeted Oncology.2015; 10(4): 597. CrossRef
Low Frequency of KRAS Mutation in Pancreatic Ductal Adenocarcinomas in Korean Patients and Its Prognostic Value
Mi Jung Kwon, Jang Yong Jeon, Hye-Rim Park, Eun Sook Nam, Seong Jin Cho, Hyung Sik Shin, Ji Hyun Kwon, Joo Seop Kim, Boram Han, Dong Hoon Kim, Yoon-La Choi
Pancreas.2015; 44(3): 484. CrossRef

IMP3, a Promising Prognostic Marker in Clear Cell Renal Cell Carcinoma: Ji Young Park, Misun Choe, Yuna Kang, Sang Sook Lee; Korean J Pathol. 2014;48(2):108-116. Published online April 28, 2014; DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.2.108

7,937 View
44 Download
4 Crossref

Abstract PDF

Background

Insulin-like growth factor II mRNA-binding protein 3 (IMP3) has been reported as a prognostic biomarker in various cancers. To validate IMP3 as a prognostic biomarker in renal cell carcinoma (RCC), we investigated the expression of IMP3, p53, and Ki-67, and their associations with clinicopathologic outcomes.

Methods

We studied 148 clear cell RCCs (CCRCCs) from patients who underwent radical nephrectomy. The expression levels of IMP3, p53, and Ki-67 were assessed by immunohistochemical staining and the clinical and pathologic parameters were retrospectively reviewed.

Results

Twenty-nine percent of CCRCCs expressed IMP3. Forty-one percent of IMP3-immunopositive tumors developed metastases, while only 11.4% of IMP3-negative tumors developed metastases (p<.001). A Kaplan-Meier curve showed that patients with IMP3-immunopositive tumors had lower metastasis-free survival and cancer-specific survival than did those with IMP3-immunonegative tumors (p<.001 and p<.001, respectively). Expression of high Ki-67 proliferation index was also associated with a higher metastatic rate. In the multivariate Cox regression analysis, pT stage and IMP3-positivity were independently associated with disease-specific survival.

Conclusions

IMP3 is an independent prognostic biomarker for patients with CCRCC to predict metastasis and poor outcome.

Citations

Citations to this article as recorded by

IMP3 Immunohistochemical Expression Is Related with Progression and Metastases in Xenografted and Cutaneous Melanomas
Natividad Martin-Morales, Miguel Padial-Molina, Isabel Tovar, Virginea De Araujo Farias, Pedro Hernández-Cortés, Esperanza Ramirez-Moreno, Mercedes Caba-Molina, Justin Davis, Alejandro Carrero Castaño, Jose Mariano Ruiz de Almodovar, Pablo Galindo-Moreno,
Pathobiology.2024; 91(2): 132. CrossRef
circRARS synergises with IGF2BP3 to regulate RNA methylation recognition to promote tumour progression in renal cell carcinoma
Yuenan Liu, Kailei Chen, Yi Shou, Sen Li, Jun Wang, Qingyang Zhang, Ziwei Huang, Jiaju Xu, Mingfeng Li, Di Liu, Huageng Liang, Hongmei Yang, Xiaoping Zhang
Clinical and Translational Medicine.2023;[Epub] CrossRef
Prognostic value of insulin‑like growth factor 2 mRNA‑binding protein 3 and vascular endothelial growth factor‑A in patients with primary non‑small‑cell lung cancer
Jiannan Liu, Ying Liu, Wenjing Gong, Xiangshuo Kong, Congcong Wang, Shuhua Wang, Aina Liu
Oncology Letters.2019;[Epub] CrossRef
Epithelial‑mesenchymal transition in colorectal carcinoma cells is mediated by DEK/IMP3
Shuping You, Yun Guan, Weihong Li
Molecular Medicine Reports.2017;[Epub] CrossRef

Tumor Sprouting in Papillary Thyroid Carcinoma Is Correlated with Lymph Node Metastasis and Recurrence: Eunjung Lee, Wonkyung Jung, Jeong-Soo Woo, Jae Bok Lee, Bong Kyung Shin, Han Kyeom Kim, Aeree Kim, Baek-hui Kim; Korean J Pathol. 2014;48(2):117-125. Published online April 28, 2014; DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.2.117

11,376 View
66 Download
7 Crossref

Abstract PDF

Background

Identification of poor prognostic factors in papillary thyroid carcinoma (PTC) patients is important for the patients' care and follow-up. We can sometimes see small tumor clusters without desmoplasia and no evidence of lymphatic emboli around the main tumor mass of PTC. We termed this form of tumor clustering, 'tumor sprouting,' and determined whether these tumors correlate with lymphovascular invasion, lymph node metastasis, and recurrence.

Methods

We analyzed a total of 204 cases of papillary thyroid macrocarcinoma. Number, size and distance from the main tumor of the tumor sprouting were observed and analyzed with clinicopathologic characteristics.

Results

Tumor sprouting was observed in 101 patients. Presence of tumor sprouting was significantly associated with positive resection margin (p=.002), lymphovascular invasion (p=.001), lymph node metastasis (p<.001), and recurrence (p=.004). Univariate analysis of recurrence-free survival revealed that tumor multiplicity (p=.037), positive resection margin (p=.007), lymphovascular invasion (p=.004), lymph node metastasis (p<.001), and tumor sprouting (p=.004) were poor prognostic factors. In multivariate analysis, positive resection margin was an independent poor prognostic factor of recurrence.

Conclusions

In conclusion, tumor sprouting is significantly correlated with lymph node metastasis and recurrence. Evaluation of tumor sprouting in PTC patients could be helpful in predicting tumor recurrence or lymph node metastasis.

Citations

Citations to this article as recorded by

Korean Thyroid Association Guidelines on the Management of Differentiated Thyroid Cancers; Part I. Initial Management of Differentiated Thyroid Cancers - Chapter 5. Evaluation of Recurrence Risk Postoperatively and Initial Risk Stratification in Different
Eun Kyung Lee, Young Shin Song, Ho-Cheol Kang, Sun Wook Kim, Dong Gyu Na, Shin Je Moon, Dong-Jun Lim, Kyong Yeun Jung, Yun Jae Chung, Chan Kwon Jung, Young Joo Park
International Journal of Thyroidology.2024; 17(1): 68. CrossRef
Significance of Lymphovascular Invasion as a Prognostic Factor in Patients with Papillary Thyroid Cancer: a Systematic Review and Meta-Analysis
Ho-Ryun Won, Bon Seok Koo
International Journal of Thyroidology.2023; 16(2): 157. CrossRef
Peripheral Versus Intraparenchymal Papillary Thyroid Microcarcinoma: Different Morphologies and PD-L1 Expression
Bozidar Kovacevic, Dragana Vucevic, Snezana Cerovic, Catarina Eloy
Head and Neck Pathology.2022; 16(1): 200. CrossRef
Lymphovascular invasion and risk of recurrence in papillary thyroid carcinoma
Katy Wagner, Earl Abraham, Bryan Tran, David Roshan, James Wykes, Peter Campbell, Ardalan Ebrahimi
ANZ Journal of Surgery.2020; 90(9): 1727. CrossRef
The Predictors of Multicentricity in Well-Differentiated Thyroid Cancer
Mohamed Hegazi, Waleed El Nahas, Mohamed Elmetwally, Amr Hassan, Waleed Gado , Islam Abdou, Ahmed Senbel, Mohamed Samir Abou-Sheishaa
Journal of Analytical Oncology.2018; 7(4): 65. CrossRef
Prognostic impact of vascular invasion in differentiated thyroid carcinoma: a systematic review and meta-analysis
Huy Gia Vuong, Tetsuo Kondo, Uyen N P Duong, Thong Quang Pham, Naoki Oishi, Kunio Mochizuki, Tadao Nakazawa, Lewis Hassell, Ryohei Katoh
European Journal of Endocrinology.2017; 177(2): 207. CrossRef
Detection of Tumor Multifocality Is Important for Prediction of Tumor Recurrence in Papillary Thyroid Microcarcinoma: A Retrospective Study and Meta-Analysis
Jung-Soo Pyo, Jin Hee Sohn, Guhyun Kang
Journal of Pathology and Translational Medicine.2016; 50(4): 278. CrossRef

Characteristics of Cutaneous Lymphomas in Korea According to the New WHO-EORTC Classification: Report of a Nationwide Study: Jae Ho Han, Young-Hyeh Ko, Yun Kyung Kang, Wan-Seop Kim, Yoon Jung Kim, Insun Kim, Hyun-Jung Kim, Soo Kee Min, Chan-Kum Park, Chan-Sik Park, Bong-Kyung Shin, Woo Ick Yang, Young-Ha Oh, Jong Sil Lee, Juhie Lee, Tae Hui Lee, Hyekyung Lee, Ho Jung Lee, Yoon Kyung Jeon, Hee Jeong Cha, Yoo-Duk Choi, Chul Woo Kim; Korean J Pathol. 2014;48(2):126-132. Published online April 28, 2014; DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.2.126

8,862 View
116 Download
14 Crossref

Abstract PDF

Background

Previously, cutaneous lymphomas were classified according to either the European Organization for the Research and Treatment of Cancer (EORTC) or the World Health Organization (WHO) classification paradigms. The aim of this study was to determine the relative frequency of Korean cutaneous lymphoma according to the new WHO-EORTC classification system.

Methods

A total of 517 patients were recruited during a recent 5 year-period (2006-2010) from 21 institutes and classified according to the WHO-EORTC criteria.

Results

The patients included 298 males and 219 females, and the mean age at diagnosis was 49 years. The lesions preferentially affected the trunk area (40.2%). The most frequent subtypes in order of decreasing prevalence were mycosis fungoides (22.2%), peripheral T-cell lymphoma (17.2%), CD30+ T-cell lymphoproliferative disorder (13.7%), and extranodal natural killer/T (NK/T) cell lymphoma, nasal type (12.0%). Diffuse large B-cell lymphoma accounted for 11.2% of cases, half of which were secondary cutaneous involvement; other types of B-cell lymphoma accounted for less than 1% of cases.

Conclusions

In comparison with data from Western countries, this study revealed relatively lower rates of mycosis fungoides and B-cell lymphoma in Korean patients, as well as higher rates of subcutaneous panniculitis-like T-cell lymphoma and NK/T cell lymphoma.

Citations

Citations to this article as recorded by

Varied presentations of primary cutaneous lymphoma: A case series from a tertiary care center in South India
Baby Shana, Betsy Ambooken, Sunitha Balakrishnan, Asokan Neelakandan, Kidangazhiyathmana Ajithkumar
Indian Journal of Cancer.2024; 61(1): 172. CrossRef
A retrospective study of prognostic factors and treatment outcome in advanced-stage Mycosis Fungoides and Sezary Syndrome
Zhuo-fan Xu, Hongyun Chen, Yuehua Liu, Wei Zhang, Hongzhong Jin, Jie Liu
Hematology.2024;[Epub] CrossRef
Prevalence, clinical features, and survival outcome trends of 627 patients with primary cutaneous lymphoma over 29 years: a retrospective review from single tertiary center in Korea
Ik Jun Moon, Chong Hyun Won, Sung Eun Chang, Chan-Sik Park, Dok-Hyun Yoon, Si Yeol Song, Mi Woo Lee, Woo Jin Lee
Scientific Reports.2024;[Epub] CrossRef
The First Case of Acute Myeloid Leukemia With t(10;11)(p13;q21);PICALM-MLLT10 Rearrangement Presenting With Extensive Skin Involvement
Min-Seung Park, Hyun-Young Kim, Jae Joon Lee, Duck Cho, Chul Won Jung, Hee-Jin Kim, Sun-Hee Kim
Annals of Laboratory Medicine.2023; 43(3): 310. CrossRef
Recent advances on cutaneous lymphoma epidemiology
G. Dobos, M. Miladi, L. Michel, C. Ram-Wolff, M. Battistella, M. Bagot, A. de Masson
La Presse Médicale.2022; 51(1): 104108. CrossRef
Specific cutaneous infiltrates in patients with haematological neoplasms: a retrospective study with 49 patients
Rebeca Calado, Maria Relvas, Francisca Morgado, José Carlos Cardoso, Oscar Tellechea
Australasian Journal of Dermatology.2021;[Epub] CrossRef
Epidemiology of Cutaneous T-Cell Lymphomas: A Systematic Review and Meta-Analysis of 16,953 Patients
Gabor Dobos, Anne Pohrt, Caroline Ram-Wolff, Céleste Lebbé, Jean-David Bouaziz, Maxime Battistella, Martine Bagot, Adèle de Masson
Cancers.2020; 12(10): 2921. CrossRef
Primary cutaneous lymphoma in Argentina: a report of a nationwide study of 416 patients
Alejandra Abeldaño, Paula Enz, Matias Maskin, Andrea B. Cervini, Natallia Torres, Ana C. Acosta, Marina Narbaitz, Silvia Vanzulli, Mirta Orentrajch, Marta A. Villareal, Maria L. Garcia Pazos, Mariana Arias, Evelyn A. Zambrano Franco, Maria I. Fontana, Rob
International Journal of Dermatology.2019; 58(4): 449. CrossRef
Post-thymic CD4 positive cytotoxic T cell infiltrates of the skin: A clinical and histomorphologic spectrum of the unique CD4 positive T cell of immunosenescence
Cynthia M. Magro, Luke C. Olson, Shabnam Momtahen
Annals of Diagnostic Pathology.2019; 38: 99. CrossRef
Cutaneous lymphomas in Taiwan: A review of 118 cases from a medical center in southern Taiwan
Chaw-Ning Lee, Chao-Kai Hsu, Kung-Chao Chang, Cheng-Lin Wu, Tsai-Yun Chen, Julia Yu-Yun Lee
Dermatologica Sinica.2018; 36(1): 16. CrossRef
Imaging analysis of superficial soft tissue lymphomas
In Sook Lee, You Seon Song, Seung Hyun Lee, Young Jin Choi, Sung Moon Lee
Clinical Imaging.2018; 49: 111. CrossRef
Epidemiologic, clinical and demographic features of primary cutaneous lymphomas in Castilla‐La Mancha, Spain: are we different?
C. Ramos‐Rodríguez, M. García‐Rojo, G. Romero‐Aguilera, M. García‐Arpa, L. González‐López, M.P. Sánchez‐Caminero, J. González‐García, M. Delgado‐Portela, M.P. Cortina‐De La Calle, M.F. Relea‐Calatayud, F. Martín‐Dávila, R. López‐Pérez, M. Ramos‐Rodríguez
Journal of the European Academy of Dermatology and Venereology.2018;[Epub] CrossRef
Nasal-type NK/T-cell lymphomas are more frequently T rather than NK lineage based on T-cell receptor gene, RNA, and protein studies: lineage does not predict clinical behavior
Mineui Hong, Taehee Lee, So Young Kang, Suk-Jin Kim, Wonseog Kim, Young-Hyeh Ko
Modern Pathology.2016; 29(5): 430. CrossRef
Cutaneous lymphoma: Kids are not just little people
Katalin Ferenczi, Hanspaul S. Makkar
Clinics in Dermatology.2016; 34(6): 749. CrossRef

Incidence and Malignancy Rates of Diagnoses in the Bethesda System for Reporting Thyroid Aspiration Cytology: An Institutional Experience: Ji Hye Park, Sun Och Yoon, Eun Ju Son, Hye Min Kim, Ji Hae Nahm, SoonWon Hong; Korean J Pathol. 2014;48(2):133-139. Published online April 28, 2014; DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.2.133

11,260 View
84 Download
38 Crossref

Abstract PDF

Background

The Bethesda System for Reporting Thyroid Cytopathology (BSRTC) uses six diagnostic categories to standardize communication of thyroid fine-needle aspiration (FNA) interpretations between clinicians and cytopathologists. Since several studies have questioned the diagnostic accuracy of this system, we examined its accuracy in our hospital.

Methods

We calculated the incidences and malignancy rates of each diagnostic category in the BSRTC for 1,730 FNAs that were interpreted by four cytopathologists in Gangnam Severance Hospital between October 1, 2011, and December 31, 2011.

Results

The diagnostic incidences of categories I-VI were as follows: 13.3%, 40.6%, 9.1%, 0.4%, 19.3%, and 17.3%, respectively. Similarly, the malignancy rates of these categories were as follows: 35.3%, 5.6%, 69.0%, 50.0%, 98.7%, and 98.9%, respectively. In categories II, V, and VI, there were no statistically significant differences in the ranges of the malignancy rates among the four cytopathologists. However, there were significant differences in the ranges for categories I and III.

Conclusions

Our findings suggest that institutions that use the BSRTC should regularly update their diagnostic criteria. We also propose that institutions issue an annual report of incidences and malignancy rates to help other clinicians improve the case management of patients with thyroid nodules.

Citations

Citations to this article as recorded by

The Malignancy Rates of the Bethesda System for Reporting Thyroid Cytopathology: A 10-year Experience in a Single Asian Institute
Sarah I Liew, Nor S Ahmad, Navarasi R Gopal
World Journal of Endocrine Surgery.2025; 16(2): 42. CrossRef
A Comprehensive Approach to the Thyroid Bethesda Category III (AUS) in the Transition Zone Between 2nd Edition and 3rd Edition of The Bethesda System for Reporting Thyroid Cytopathology: Subcategorization, Nuclear Scoring, and More
Merve Bagıs, Nuray Can, Necdet Sut, Ebru Tastekin, Ezgi Genc Erdogan, Buket Yilmaz Bulbul, Yavuz Atakan Sezer, Osman Kula, Elif Mercan Demirtas, Inci Usta
Endocrine Pathology.2024; 35(1): 51. CrossRef
Evaluation of the Efficacy of Thyroid Imaging Reporting and Data Systems Classification in Risk Stratification and in the Management of Thyroid Swelling by Comparing It With Fine-Needle Aspiration Cytology and Histopathological Examination
Abhishek K Saw, Zenith H Kerketta, Khushboo Rani, Krishna Murari, Kritika Srivastava, Ajay Kumar, Sunny LNU, Anish Baxla, Nabu Kumar, Nusrat Noor
Cureus.2024;[Epub] CrossRef
A COMPARATIVE STUDY BETWEEN CONVENTIONAL METHOD AND THE BETHESDA SYSTEM FOR REPORTING THYROID CYTOPATHOLOGY
Pooja Mangal, Arti Gupta
GLOBAL JOURNAL FOR RESEARCH ANALYSIS.2023; : 67. CrossRef
Study of Fine Needle Aspiration Cytology (FNAC) of Thyroid Gland According to the Bethesda System
Keval A Patel, Garima Anandani, Bhawana S Sharma, Riddhi A Parmar
Cureus.2023;[Epub] CrossRef
Correlation of Thyroid Fine Needle Aspiration Biopsy With Histopathological Results
Cemalettin Durgun
Cureus.2023;[Epub] CrossRef
The Bethesda System for Reporting Thyroid Cytopathology: Validating at Tribhuvan University Teaching Hospital
Kunjan Acharya, Shreya Shrivastav, Prashant Triipathi, Bigyan Raj Gyawali, Bijaya Kharel, Dharma Kanta Baskota, Pallavi Sinha
International Archives of Otorhinolaryngology.2022; 26(01): e097. CrossRef
Validating the ‘CUT score’ risk stratification tool for indeterminate thyroid nodules using the Bethesda system for reporting thyroid cytopathology
Sapir Pinhas, Idit Tessler, Luba Pasherstnik Bizer, Khaled khalilia, Meir Warman, Meital Adi, Doron Halperin, Oded Cohen
European Archives of Oto-Rhino-Laryngology.2022; 279(1): 383. CrossRef
ANALYSIS OF FINE NEEDLE ASPIRATIONS OF THE THYROID: CYTOLOGICAL-HISTOPATHOLOGICAL CORRELATION AND OUTCOMES OF THE BETHESDA SYSTEM
Ayca TAN
SDÜ Tıp Fakültesi Dergisi.2022; 29(2): 213. CrossRef
Reproducibility of Cytomorphological Diagnosis and Assessment of Risk of Malignancy of Thyroid Nodules Based on the Bethesda System for Reporting Thyroid Cytopathology
Sasmita Panda, Mamita Nayak, Lucy Pattanayak, Paresh Kumar Behera, Sagarika Samantaray, Sashibhusan Dash
Journal of Microscopy and Ultrastructure.2022; 10(4): 174. CrossRef
Comparative analysis of cytomorphology of thyroid lesion on conventional cytology versus liquid-based cytology and categorize the lesions according to The Bethesda System for Reporting Thyroid Cytopathology
M Qamar Alam, Pinki Pandey, Megha Ralli, Jitendra Pratap Singh Chauhan, Roopak Aggarwal, Vineet Chaturvedi, Asttha Kapoor, Kapil Trivedi, Savita Agarwal
Journal of Cancer Research and Therapeutics.2022; 18(Suppl 2): S259. CrossRef
Thyroid cytology in Pakistan: An institutional audit of the atypia of undetermined significance/follicular lesion of undetermined significance category
Saira Fatima, Rabia Qureshi, Sumbul Imran, Romana Idrees, Zubair Ahmad, Naila Kayani, Arsalan Ahmed
Cytopathology.2021; 32(2): 205. CrossRef
Outcomes of the Bethesda system for reporting thyroid cytopathology: Real‐life experience
Galit Avior, Or Dagan, Isaac Shochat, Yulia Frenkel, Idit Tessler, Alona Meir, Anat Jaffe, Oded Cohen
Clinical Endocrinology.2021; 94(3): 521. CrossRef
National differences in cost analysis of Afirma Genomic sequencing classifier
Ohad Ronen, Maya Oichman
Clinical Endocrinology.2021; 94(4): 717. CrossRef
Thyroid malignancy rates according to the Bethesda reporting system in Israel - A multicenter study
Ory Madgar, Galit Avior, Isaac Shochat, Ben-Zion Joshua, Lior Baraf, Yuval Avidor, Avi khafif, Niddal Assadi, Eran E. Alon
European Journal of Surgical Oncology.2021; 47(6): 1370. CrossRef
Application of the Bethesda system for reporting thyroid cytopathology for classification of thyroid nodules: A clinical and cytopathological characteristics in Bhutanese population
Sonam Choden, Chimi Wangmo, Sushna Maharjan
Diagnostic Cytopathology.2021; 49(11): 1179. CrossRef
Malignancy rates in thyroid nodules classified as Bethesda categories III and IV; a subcontinent perspective
Adnan Zahid, Waqas Shafiq, Khawaja Shehryar Nasir, Asif Loya, Syed Abbas Raza, Sara Sohail, Umal Azmat
Journal of Clinical & Translational Endocrinology.2021; 23: 100250. CrossRef
The combination of ACR‐Thyroid Imaging Reporting and Data system and The Bethesda System for Reporting Thyroid Cytopathology in the evaluation of thyroid nodules—An institutional experience
Shanmugasundaram Sakthisankari, Sreenivasan Vidhyalakshmi, Sivanandam Shanthakumari, Balalakshmoji Devanand, Udayasankar Nagul
Cytopathology.2021; 32(4): 472. CrossRef
Ultrasound-guided fine needle aspiration cytology and ultrasound examination of thyroid nodules in the UAE: A comparison
Suhail Al-Salam, Charu Sharma, Maysam T. Abu Sa’a, Bachar Afandi, Khaled M. Aldahmani, Alia Al Dhaheri, Hayat Yahya, Duha Al Naqbi, Esraa Al Zuraiqi, Baraa Kamal Mohamed, Shamsa Ahmed Almansoori, Meera Al Zaabi, Aysha Al Derei, Amal Al Shamsi, Juma Al Kaa
PLOS ONE.2021; 16(4): e0247807. CrossRef
Incidence, Clinical Characteristics, and Histopathological Results of Atypia of Undermined Significance in a Tertiary Center in UAE
Maha Osman Shangab, Azza Abdulaziz Khalifa, Fatheya Al Awadi, Mouza Alsharhan, Alaaeldin Bashier
Dubai Diabetes and Endocrinology Journal.2021; 27(1): 1. CrossRef
McGill Thyroid Nodule Score in Differentiating Thyroid Nodules in Total Thyroidectomy Cases of Indeterminate Nodules
Hadi A Al-Hakami, Reem Al-Mohammadi, Rami Al-Mutairi, Haya Al-Subaie, Mohammed A Al Garni
Indian Journal of Surgical Oncology.2020; 11(2): 268. CrossRef
The Bethesda System for Reporting Thyroid Cytopathology: A Cytohistological Study
Bakiarathana Anand, Anita Ramdas, Marie Moses Ambroise, Nirmal P. Kumar
Journal of Thyroid Research.2020; 2020: 1. CrossRef
Differences in cytopathologist thyroid nodule malignancy rate
Ohad Ronen, Hector Cohen, Eyal Sela, Mor Abu
Cytopathology.2020; 31(4): 315. CrossRef
Thyroid Multimodal Ultrasound Evaluation—Impact on Presurgical Diagnosis of Intermediate Cytology Cases
Andreea Borlea, Dana Stoian, Laura Cotoi, Ioan Sporea, Fulger Lazar, Ioana Mozos
Applied Sciences.2020; 10(10): 3439. CrossRef
Fine-needle aspiration cytology of nodular thyroid lesions: A 1-year experience of the thyroid cytopathology in a large regional and a University Hospital, with histological correlation
Kaumudi Konkay, Radhika Kottu, Mutheeswaraiah Yootla, Narendra Hulikal
Thyroid Research and Practice.2019; 16(2): 60. CrossRef
Review of a single institution's fine needle aspiration results for thyroid nodules: Initial observations and lessons for the future
Ohad Ronen, Hector Cohen, Mor Abu
Cytopathology.2019; 30(5): 468. CrossRef
Strain Elastography as a Valuable Diagnosis Tool in Intermediate Cytology (Bethesda III) Thyroid Nodules
Dana Stoian, Florin Borcan, Izabella Petre, Ioana Mozos, Flore Varcus, Viviana Ivan, Andreea Cioca, Adrian Apostol, Cristina Adriana Dehelean
Diagnostics.2019; 9(3): 119. CrossRef
Improvement of diagnostic performance of pathologists by reducing the number of pathologists responsible for thyroid fine needle aspiration cytology: An institutional experience
Jae Yeon Seok, Jungsuk An, Hyun Yee Cho
Diagnostic Cytopathology.2018; 46(7): 561. CrossRef
Bethesda Classification and Cytohistological Correlation of Thyroid Nodules in a Brazilian Thyroid Disease Center
Kassia B. Reuters, Maria C.O.C. Mamone, Elsa S. Ikejiri, Cleber P. Camacho, Claudia C.D. Nakabashi, Carolina C.P.S. Janovsky, Ji H. Yang, Danielle M. Andreoni, Rosalia Padovani, Rui M.B. Maciel, Felipe A.B. Vanderlei, Rosa P.M. Biscolla
European Thyroid Journal.2018; 7(3): 133. CrossRef
The impact of rapid on‐site evaluation on thyroid fine‐needle aspiration biopsy: A 2‐year cancer center institutional experience
Ricardo G. Pastorello, Camila Destefani, Pedro H. Pinto, Caroline H. Credidio, Rafael X. Reis, Thiago de A. Rodrigues, Maryane C. de Toledo, Louise De Brot, Felipe de A. Costa, Antonio G. do Nascimento, Clóvis A. L. Pinto, Mauro A. Saieg
Cancer Cytopathology.2018; 126(10): 846. CrossRef
The Use of the Bethesda System for Reporting Thyroid Cytopathology in Korea: A Nationwide Multicenter Survey by the Korean Society of Endocrine Pathologists
Mimi Kim, Hyo Jin Park, Hye Sook Min, Hyeong Ju Kwon, Chan Kwon Jung, Seoung Wan Chae, Hyun Ju Yoo, Yoo Duk Choi, Mi Ja Lee, Jeong Ja Kwak, Dong Eun Song, Dong Hoon Kim, Hye Kyung Lee, Ji Yeon Kim, Sook Hee Hong, Jang Sihn Sohn, Hyun Seung Lee, So Yeon Pa
Journal of Pathology and Translational Medicine.2017; 51(4): 410. CrossRef
Thyroid FNA cytology in Asian practice—Active surveillance for indeterminate thyroid nodules reduces overtreatment of thyroid carcinomas
K. Kakudo, M. Higuchi, M. Hirokawa, S. Satoh, C. K. Jung, A. Bychkov
Cytopathology.2017; 28(6): 455. CrossRef
Thyroid Fine-Needle Aspiration Cytology Practice in Korea
Yoon Jin Cha, Ju Yeon Pyo, SoonWon Hong, Jae Yeon Seok, Kyung-Ju Kim, Jee-Young Han, Jeong Mo Bae, Hyeong Ju Kwon, Yeejeong Kim, Kyueng-Whan Min, Soonae Oak, Sunhee Chang
Journal of Pathology and Translational Medicine.2017; 51(6): 521. CrossRef
Bethesda System for Reporting Thyroid Cytopathology: A three-year study at a tertiary care referral center in Saudi Arabia
Mohamed Abdulaziz Al Dawish, Asirvatham Alwin Robert, Aljuboury Muna, Alkharashi Eyad, Abdullah Al Ghamdi, Khalid Al Hajeri, Mohammed A Thabet, Rim Braham
World Journal of Clinical Oncology.2017; 8(2): 151. CrossRef
A meta‐analytic review of the Bethesda System for Reporting Thyroid Cytopathology: Has the rate of malignancy in indeterminate lesions been underestimated?
Patrizia Straccia, Esther Diana Rossi, Tommaso Bizzarro, Chiara Brunelli, Federica Cianfrini, Domenico Damiani, Guido Fadda
Cancer Cytopathology.2015; 123(12): 713. CrossRef
Value of TIRADS, BSRTC and FNA-BRAFV600E mutation analysis in differentiating high-risk thyroid nodules
Yu-zhi Zhang, Ting Xu, Dai Cui, Xiao Li, Qing Yao, Hai-yan Gong, Xiao-yun Liu, Huan-huan Chen, Lin Jiang, Xin-hua Ye, Zhi-hong Zhang, Mei-ping Shen, Yu Duan, Tao Yang, Xiao-hong Wu
Scientific Reports.2015;[Epub] CrossRef
A study of malignancy rates in different diagnostic categories of the Bethesda system for reporting thyroid cytopathology: An institutional experience
P. Arul, C. Akshatha, Suresh Masilamani
Biomedical Journal.2015; 38(6): 517. CrossRef
Diagnostic accuracy of Bethesda system for reporting thyroid cytopathology: an institutional perspective
Samreen Naz, Atif Hashmi, Amna khurshid, Naveen Faridi, Muhammad Edhi, Anwar Kamal, Mehmood Khan
International Archives of Medicine.2014; 7(1): 46. CrossRef

Case Studies

Follicular Dendritic Cell Sarcoma of the Inflammatory Pseudotumor-like Variant Presenting as a Colonic Polyp: Shien-Tung Pan, Chih-Yuan Cheng, Nie-Sue Lee, Peir-In Liang, Shih-Sung Chuang; Korean J Pathol. 2014;48(2):140-145. Published online April 28, 2014; DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.2.140

9,813 View
100 Download
33 Crossref

Abstract PDF

Follicular dendritic cell (FDC) sarcoma is rare and is classified either as conventional type or inflammatory pseudotumor (IPT)-like variant. Extranodal presentation is uncommon and nearly all gastrointestinal FDC tumors are of the conventional type. IPT-like variant tumors occur almost exclusively in the liver and spleen and are consistently associated with Epstein-Barr virus (EBV). Here we report the case of a 78-year-old woman with an IPT-like FDC sarcoma presenting as a pedunculated colonic polyp. Histologically, scanty atypical ovoid to spindle cells were mixed with a background of florid lymphoplasmacytic infiltrate, which led to an initial misdiagnosis of pseudolymphoma. These atypical cells expressed CD21, CD23, CD35, and D2-40, and were positive for EBV by in situ hybridization, confirming the diagnosis. The patient was free of disease five months after polypectomy without adjuvant therapy. Although extremely rare, the differential diagnosis for colonic polyp should include FDC sarcoma to avoid an erroneous diagnosis. A review of the 24 cases of IPT-like FDC sarcoma reported in the literature reveal that this tumor occurs predominantly in females with a predilection for liver and spleen, and has a strong association with EBV.

Citations

Citations to this article as recorded by

The fifth edition of the WHO classification of mature T cell, NK cell and stroma-derived neoplasms
Ayoma D Attygalle, Kennosuke Karube, Yoon Kyung Jeon, Wah Cheuk, Govind Bhagat, John K C Chan, Kikkeri N Naresh
Journal of Clinical Pathology.2025; 78(4): 217. CrossRef
What is new in the 5th edition of the World Health Organization classification of mature B and T/NK cell tumors and stromal neoplasms?
Ayoma D. Attygalle, John K. C. Chan, Sarah E. Coupland, Ming-Qing Du, Judith A. Ferry, Daphne de Jong, Dita Gratzinger, Megan S. Lim, Alina Nicolae, German Ott, Andreas Rosenwald, Anna Schuh, Reiner Siebert
Journal of Hematopathology.2024; 17(2): 71. CrossRef
Pathologic characteristics of histiocytic and dendritic cell neoplasms
Sun Och Yoon
Blood Research.2024;[Epub] CrossRef
Epstein-barr virus (EBV)-positive inflammatory pseudotumor-like follicular dendritic cell sarcoma (IPT-like FDCS) presenting as thrombocytopenia: A case report and literature review
Jiawei Jin, Xiaolong Zhu, Yi Wan, Yang Shi
Heliyon.2024; 10(12): e32997. CrossRef
EBV-positive inflammatory follicular dendritic cell sarcoma of the colon with clonal immunoglobulin gene rearrangement: A case report and literature review
Xia Xu, Xiuzhen Li, Qun Deng, Kaihang Yu, Jinfan Li
Heliyon.2024; 10(11): e31947. CrossRef
Challenges in the Diagnosis of Epstein-Barr Virus-positive Inflammatory Follicular Dendritic Cell Sarcoma
Yan Li, Xia Yang, Lili Tao, Weimei Zeng, Min Zuo, Shuo Li, Liyan Wu, Yanshong Lin, Ziying Zhang, Jingping Yun, Yuhua Huang
American Journal of Surgical Pathology.2023; 47(4): 476. CrossRef
Epstein-Barr Virus-Positive Inflammatory Follicular Dendritic Cell Sarcoma Presenting as a Colonic Polyp: Report of a Case with a Literature Review
Jiahui Hu, Dongdong Huang, Chengfu Xu, Yi Chen, Han Ma, Zhe Shen
Medicina.2023; 59(7): 1341. CrossRef
A Clinicopathology Review and Update of Epstein–Barr Virus-Associated Mesenchymal Tumors
Oswald Zhao Jian Lee, Noorjehan Omar, Joshua K. Tay, Victor Kwan Min Lee
Cancers.2023; 15(23): 5563. CrossRef
Granulomatous splenic mass with necrosis revealing an EBV-positive inflammatory follicular dendritic cell sarcoma
Irena Antonia Ungureanu, Renato Micelli Lupinacci, Marie Parrens, Jean-François Emile
Journal of Surgical Case Reports.2022;[Epub] CrossRef
Case report: Hepatic inflammatory pseudotumor-like follicular dendritic cell sarcoma: A rare case and minireview of the literature
Fan Ding, Chao Wang, Chi Xu, Hui Tang
Frontiers in Medicine.2022;[Epub] CrossRef
Follicular dendritic cell sarcoma of gastrointestinal tract with two emerging distinct subtypes: a case report and systemic review
Hongxing Gui, Jigisha Chaudhari, Rifat Mannan
Diagnostic Pathology.2022;[Epub] CrossRef
Surgical treatment of liver inflammatory pseudotumor-like follicular dendritic cell sarcoma: A case report
Li-Yue Fu, Jiu-Liang Jiang, Meng Liu, Jun-Jun Li, Kai-Ping Liu, Hai-Tao Zhu
World Journal of Gastrointestinal Oncology.2022; 14(11): 2288. CrossRef
Inflammatory pseudotumor-like follicular/fibroblastic dendritic cell sarcoma: focus on immunohistochemical profile and association with Epstein-Barr virus
Francesca Pagliuca, Andrea Ronchi, Annamaria Auricchio, Eva Lieto, Renato Franco
Infectious Agents and Cancer.2022;[Epub] CrossRef
Recent Advances in Digestive Tract Tumors: Updates From the 5th Edition of the World Health Organization “Blue Book”
Raul S. Gonzalez, Anwar Raza, Robert Propst, Oyedele Adeyi, Justin Bateman, Sabrina C. Sopha, Janet Shaw, Aaron Auerbach
Archives of Pathology & Laboratory Medicine.2021; 145(5): 607. CrossRef
Hepatic inflammatory pseudotumor-like follicular dendritic cell tumor: a case report
Ana Daniela Pascariu, Andreea Ioana Neagu, Andrei Valentin Neagu, Alexandru Băjenaru, Cezar Iulian Bețianu
Journal of Medical Case Reports.2021;[Epub] CrossRef
Inflammatory pseudotumor-like follicular dendritic cell sarcoma: Literature review of 67 cases
Hao Wu, Peng Liu, Xiao-Ran Xie, Jing-Shu Chi, Huan Li, Can-Xia Xu
World Journal of Meta-Analysis.2021; 9(1): 1. CrossRef
New Clinicopathologic Scenarios of EBV+ Inflammatory Follicular Dendritic Cell Sarcoma
Xiang-Nan Jiang, Yan Zhang, Tian Xue, Jie-Yu Chen, Alex C.L. Chan, Wah Cheuk, John K.C. Chan, Xiao-Qiu Li
American Journal of Surgical Pathology.2021; 45(6): 765. CrossRef
Select Epstein-Barr Virus–Associated Digestive Tract Lesions for the Practicing Pathologist
Zainab I. Alruwaii, Elizabeth A. Montgomery
Archives of Pathology & Laboratory Medicine.2021; 145(5): 562. CrossRef
Overview of Gastrointestinal Lymphoproliferative disorders✰
Aaron Auerbach, Nadine S. Aguilera
Seminars in Diagnostic Pathology.2021; 38(4): 1. CrossRef
Follicular dendritic cell sarcoma
Fabio Facchetti, Matteo Simbeni, Luisa Lorenzi
Pathologica.2021; 113(5): 316. CrossRef
Hepatic inflammatory pseudotumor-like follicular dendritic cell tumor with hepatic lymphoma history
Jiang Li, Hai-su Tao, Dong Chen, Zhi-yong Huang, Er-lei Zhang
Medicine.2021; 100(39): e27392. CrossRef
Clinicopathological characteristics of extranodal follicular dendritic cell sarcoma: A report of two cases
Xing Zhao, Dayong Sun, Gang Zhang
Oncology Letters.2021;[Epub] CrossRef
Inflammatory pseudotumour-like follicular dendritic cell tumour of the colon with plasmacytosis mimicking EBV-positive lymphoproliferative disorder
Ying-Ren Chen, Chi-Lin Lee, Yen-Chien Lee, Kung-Chao Chang
Pathology.2020; 52(4): 484. CrossRef
Beware the inflammatory cell-rich colonic polyp: a rare case of EBV-positive inflammatory pseudotumour-like follicular dendritic cell sarcoma with increased IgG4-positive plasma cells
Lynne Goh, Nan Zun Teo, Lai Mun Wang
Pathology.2020; 52(6): 713. CrossRef
Epstein–Barr virus‐positive inflammatory follicular dendritic cell sarcoma presenting as a solitary colonic mass: two rare cases and a literature review
Xiaokang Ke, Huihua He, Qingping Zhang, Jingping Yuan, Qilin Ao
Histopathology.2020; 77(5): 832. CrossRef
Inflammatory pseudotumor-like follicular dendritic cell sarcoma: A brief report of two cases
Bi-Xi Zhang, Zhi-Hong Chen, Yu Liu, Yuan-Jun Zeng, Yan-Chun Li
World Journal of Gastrointestinal Oncology.2019; 11(12): 1231. CrossRef
Epstein-Barr virus (EBV)–associated lymphoid proliferations, a 2018 update
Sherif A. Rezk, Xiaohui Zhao, Lawrence M. Weiss
Human Pathology.2018; 79: 18. CrossRef
A Rare Case of Epstein-Barr Virus Negative Inflammatory Pseudotumor-like Follicular Dendritic Cell Sarcoma Presenting as a Solitary Colonic Mass in a 53-Year-Old Woman; Case Report and Review of Literature
Rossana Kazemimood, Farid Saei Hamedani, Asma Sharif, Sujata Gaitonde, Elizabeth Wiley, Pier Cristoforo Giulianotti, John Vincent Groth
Applied Immunohistochemistry & Molecular Morphology.2017; 25(5): e30. CrossRef
A Case of Inflammatory Pseudotumor-like Follicular Dendritic Cell Sarcoma of the Lymph Node in the Small Bowel Mesentery Accompanied by Myasthenia Gravis
Daichi KITAGUCHI, Katsuji HISAKURA, Taiki SATO, Masanao KURATA, Tatsuya ODA, Nobuhiro OHKOHCHI
Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2017; 78(3): 527. CrossRef
Clinicopathological features of inflammatory pseudotumour‐like follicular dendritic cell tumour of the abdomen
Yanyang Chen, Huijuan Shi, Hui Li, Tiantian Zhen, Anjia Han
Histopathology.2016; 68(6): 858. CrossRef
A Rare Case of Follicular Dendritic Cell Sarcoma with Pseudochylous Effusion and Review of Literature From India
Kamal Kant Sahu, Gaurav Prakash, Sandeep Rao, Amanjit Bal, Pankaj Malhotra, Jasmina Ahluwalia, Rakesh K. Vashistha
Indian Journal of Hematology and Blood Transfusion.2015; 31(2): 307. CrossRef
Epstein-Barr virus–associated inflammatory pseudotumor presenting as a colonic mass
Shunyou Gong, Iwona Auer, Rajan Duggal, Stefania Pittaluga, Mark Raffeld, Elaine S. Jaffe
Human Pathology.2015; 46(12): 1956. CrossRef
Response of follicular dendritic cell sarcoma to gemcitabine and docetaxel: report of two cases and literature review
Robert M Conry
Clinical Sarcoma Research.2014;[Epub] CrossRef

Multifocal Osteosarcoma of the Skull: Multiple Primary or Metastatic? A Case Report: Hyuck Cho, Bong-jin Park, Yong-Koo Park; Korean J Pathol. 2014;48(2):146-150. Published online April 28, 2014; DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.2.146

9,394 View
54 Download
7 Crossref

Abstract PDF

Osteosarcoma of the skull is a very rare condition. Moreover, it is extremely rare for osteosarcoma to present as multiple lesions confined to the skull. A 58-year-old woman was admitted with two masses in the parietal area of the skull, accompanied by mild headache and tenderness. Imaging revealed two masses with a heterogeneous consistency in the cranial bones. Excision craniectomy was performed and the pathology was consistent with osteoblastic osteosarcoma. Two nodules in the heart were found on routine follow-up imaging while the patient was undergoing chemotherapy. The nodules were biopsied and found to be metastatic osteosarcoma.

Citations

Citations to this article as recorded by

A telomere-related signature for predicting prognosis and assessing immune microenvironment in osteosarcoma
Shihao Li, Lina Zhang, Haiyang Zhang
Frontiers in Pharmacology.2025;[Epub] CrossRef
Osteosarcoma multicéntrico sincrónico. Un caso en niño de 10 años y revisión de la literatura
Jesús Pérez-García, Osvaldo Velasco-Donado, Karoll Robles-Pérez
Revista Española de Patología.2022; 55: S11. CrossRef
Reconstruction using a frozen autograft for a skull and humeral lesion of synchronous multicentric osteosarcoma after undergoing successful neoadjuvant chemotherapy: a case report and review of the literature
Yoshihiro Araki, Katsuhiro Hayashi, Norio Yamamoto, Akihiko Takeuchi, Shinji Miwa, Kentaro Igarashi, Takashi Higuchi, Kensaku Abe, Yuta Taniguchi, Hirotaka Yonezawa, Sei Morinaga, Yohei Asano, Takayuki Nojima, Hiroyuki Tsuchiya
BMC Surgery.2021;[Epub] CrossRef
What’s that big thing on your head? Diagnosis of a large frontoparietal lesion on an Eastern Zhou skull from Henan, China
Kate Pechenkina, Wenquan Fan, Xiaodong Luo
International Journal of Paleopathology.2019; 26: 84. CrossRef
Kalvaryumda multifokal osteosarkom: Nadir bir vaka sunumu ve literatür derlemesi
Neslihan KURTUL, Nursel YURTTUTAN, A. Yasir BAHAR, Gökmen AKTAŞ
Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi.2019; 14(3): 151. CrossRef
Radiological review of skull lesions
Carrie K. Gomez, Scott R. Schiffman, Alok A. Bhatt
Insights into Imaging.2018; 9(5): 857. CrossRef
Multifocal Osteosarcoma
Somali Gavane, Anita P. Price, Heather Magnan, Sonia Mahajan, Neeta Pandit-Taskar
Clinical Nuclear Medicine.2017; 42(4): e202. CrossRef

Different Protein Expressions between Peripheral Ameloblastoma and Oral Basal Cell Carcinoma Occurred at the Same Mandibular Molar Area: Yeon Sook Kim, Suk Keun Lee; Korean J Pathol. 2014;48(2):151-158. Published online April 28, 2014; DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.2.151

9,195 View
76 Download
5 Crossref

Abstract PDF

Peripheral ameloblastoma (PA) in gingiva is rare and often confused with oral basal cell carcinoma (OBCC). The tissues of one case of PA and one case of OBCC with the same mandibular molar area affected were compared via an immunohistochemical examination using 50 antisera. The PA and OBCC showed similar proliferation of basaloid epithelial strands, but toluidine blue staining revealed that the PA had pinkish juxta-epithelial myxoid tissue, whereas the OBCC was infiltrated by many mast cells. Immunohistochemical comparisons showed that the PA was strongly positive for ameloblastin, KL1, p63, carcinoembryonic antigen, focal adhesion kinase, and cathepsin K, and slightly positive for amelogenin, Krox-25, E-cadherin, and PTCH1, whereas the OBCC was not. On the other hand, the OBCC was strongly positive for EpCam, matrix metalloprotease (MMP)-1, α1-antitrypsin, cytokeratin-7, p53, survivin, pAKT1, transforming growth factor-β1, NRAS, TGase-1, and tumor nescrosis factor-α, and consistently positive for β-catenin, MMP-2, cathepsin G, TGase-2, SOS-1, sonic hedgehog, and the β-defensins-1, -2, -3, while the PA was not. These data suggest that the tumorigeneses of PA and OBCC differ, and that PAs undergo odontogenic differentiation and generate oncogenic signals for infiltrative growth and bone resorption, whereas OBCCs undergo basaloid epidermal differentiation as a result of growth factor/cytokine-related oncogenic signals.

Citations

Citations to this article as recorded by

Immunohistochemical Analysis of Dentigerous Cysts and Odontogenic Keratocysts Associated with Impacted Third Molars—A Systematic Review
Luis Almeida, David Lloyd, Daniel Boettcher, Olivia Kraft, Samuel Zammuto
Diagnostics.2024; 14(12): 1246. CrossRef
Role of HIF-1α in Ameloblastoma: A Systematic Review
Ayushi Jain, Pooja Sharma, N Sivakumar, Priya Devi, Shalini Gupta, Shaleen Chandra
Indian Journal of Otolaryngology and Head & Neck Surgery.2023; 75(4): 3136. CrossRef
Expression of ameloblastin in the human tooth germ and ameloblastoma
Suganya Panneer Selvam, Irulandy Ponniah
Oral Diseases.2018; 24(8): 1538. CrossRef
The Use of BEREP4 Immunohistochemistry Staining for Detection of Basal Cell Carcinoma
Anthony Paulo Sunjaya, Angela Felicia Sunjaya, Sukmawati Tansil Tan
Journal of Skin Cancer.2017; 2017: 1. CrossRef
Peripheral ameloblastoma of the mandible: A case report
Takahiro Kaneko, Satoshi Nakamura, Ryutarou Kawano, Norio Horie, Tetsuo Shimoyama
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology.2016; 28(6): 565. CrossRef

Brief Case Reports

Adenocarcinoma Arising in Gastric Duplication Cyst: Hyo Jeong Kang, Se Jin Jang, Young Soo Park; Korean J Pathol. 2014;48(2):159-161. Published online April 28, 2014; DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.2.159

7,288 View
52 Download
10 Crossref

PDF

Citations

Citations to this article as recorded by

Low-Grade Mucinous Neoplasm Arising in an Enteric Duplication Cyst of Pancreas: A Case Report and Literature Review
Mengjing Fan, Fang Yang
International Journal of Surgical Pathology.2024; 32(2): 422. CrossRef
Mixed Pancreatobiliary Ductal Adenocarcinoma and Squamous Cell Carcinoma Arising from an Ectopic Pancreas in a Gastric Duplication Cyst—A Rare Double Diagnosis
Minhye Kim, Jungwook Yang, Daehyun Song, Hyojung An, Dongchul Kim
Diagnostics.2024; 14(23): 2727. CrossRef
Resección laparoscópica de quiste de duplicación gástrica asistida por endoscopia
Camilo Naranjo-Salazar, Juan Esteban Botero-Velásquez, Mauricio Moreno
Revista Colombiana de Cirugía.2023;[Epub] CrossRef
Clinical features of gastric duplications: evidence from primary case reports and published data
Yang Li, Chen Li, Hao Wu, Quan Wang, Zhi-Dong Gao, Xiao-Dong Yang, Ke-Wei Jiang, Ying-Jiang Ye
Orphanet Journal of Rare Diseases.2021;[Epub] CrossRef
Sarcomatoid Carcinoma Arising in a Gastric Duplication Cyst
Mohamed A. H. Ahmed, Kanchana Sanjeewani Liyanaarachchi, Shaun R. Preston, Madeleine Hewish, Izhar N. Bagwan
ACG Case Reports Journal.2021; 8(5): e00584. CrossRef
Pancreatobiliary Adenocarcinoma in a Gastric Duplication Cyst: A Doubly Rare Diagnosis
Ana Rolo, Rui Caetano Oliveira, Bárbara Lima, Ana Barbosa, Ilda Faustino
Cureus.2021;[Epub] CrossRef
Adenocarcinoma Arising From a Gastric Duplication Cyst With Lymph Node Metastasis
Shoichi Kinugasa, Hiroyuki Monma, Yoshio Sakamoto, Takafumi Watanabe, Masayo Fujimoto
Cureus.2020;[Epub] CrossRef
Adult Gastric Bronchogenic Cyst With Elevated Tumor Marker in Containing Fluid: A Case Report and Literature Review
Jixuan Duan, Sheng Yan, Qiyi Zhang, Jingjin Wu, Yu Du, K. G Owusu-Ansah, Shusen Zheng
International Surgery.2019; 104(1-2): 58. CrossRef
Papillary Adenocarcinoma in a Gastric Duplication Cyst
Sonali Sethi, Satyajit Godhi, Sunil Kumar Puri
Indian Journal of Surgical Oncology.2018; 9(1): 79. CrossRef
Non‐communicating gastric duplication cyst in a 10‐week‐old Labrador Retriever puppy
MW Jack, D Burgess, A Griffin
Australian Veterinary Journal.2016; 94(5): 166. CrossRef

Esophageal Squamous Cell Carcinoma In Situ Overlying Leiomyoma Mimicking Invasive Cancer: A Brief Case Report: Woo Jin Oh, Eun Jung Lee, Youn Soo Lee, Tae-Jung Kim; Korean J Pathol. 2014;48(2):162-163. Published online April 28, 2014; DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.2.162

6,561 View
42 Download
2 Crossref

PDF

Citations

Citations to this article as recorded by

Esophageal squamous cell carcinoma or high-grade dysplasia overlying leiomyoma, rare but not to be neglected
Changyuan Guo, Dan Liu, Yong Liu, Lei Guo, Lulu Rong, Guiqi Wang, Ning Lu, Liyan Xue
Esophagus.2021; 18(1): 125. CrossRef
Esophageal leiomyoma and simultaneous overlying squamous cell carcinoma: a case report and review of the literature
Saadat Mehrabi, Mohammad Javad Yavari Barhaghtalab, Safoora Hejazinia, Hossein Saedi
BMC Surgery.2021;[Epub] CrossRef

Simultaneous Occurrence of Ductal Carcinoma In Situ within Juvenile Fibroadenoma in Both Breasts: A Brief Case Report: Mi Jung Kwon, Hye-Rim Park, Jinwon Seo, Dong Hoon Kim, Kyoonsoon Jung, Young Ah Lim, Lee Su Kim, Hoonsik Bae, In Ae Park, Soo Kee Min; Korean J Pathol. 2014;48(2):164-166. Published online April 28, 2014; DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.2.164

7,707 View
51 Download
1 Crossref

PDF

Citations

Citations to this article as recorded by

Breast Carcinoma within Fibroadenoma: A Systematic Review
Abdulwahid M. Salih, Lana R.A. Pshtiwan, Mohammed Gh. Hamasaeed, Sami S. Omar, Shaban Latif, Shadi H. Sidiq, Bushra O. Hussein, Hunar A. Hassan, Diyar A. Omar, Sarhang S. Abdalla, Hemn A. Hassan, Yousif M. Mahmood, Marwan N. Hassan, Dahat A.
Barw Medical Journal.2024;[Epub] CrossRef

An Unusual Case of Pulmonary Mucous Gland Adenoma with Fibromyxoid Stroma and Cartilage Islands in 68-Year-Old Woman: Boram Lee, In Ho Choi, Joungho Han, Kyung Soo Lee, Young Mog Shim; Korean J Pathol. 2014;48(2):167-169. Published online April 28, 2014; DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.2.167

7,719 View
51 Download
7 Crossref

PDF

Citations

Citations to this article as recorded by

Case report: Bronchoscopic intervention for rare benign airway tumors: a report of 4 cases and literature review
Zhifang Cui, Jinhong Wang, Hongwu Wang, Lei Li, Xiaohui Si, Yanbin Zhang, Heng Zou
Frontiers in Oncology.2024;[Epub] CrossRef
Extremely Rare Coexistence of Peripherally Located Mucous Gland Adenoma and Pulmonary Chondroid Hamartoma
Sevilay Özmen, Funda Demirağ, Harika Derya Tamer, Adem Karaman, Yener Aydın
British Journal of Hospital Medicine.2024; : 1. CrossRef
Peripheral pulmonary mucous gland adenoma with a cavity mimicking lung cancer
Hiroaki Komatsu, Nobuhiro Izumi, Takuma Tsukioka, Hidetoshi Inoue, Ryuichi Ito, Yumi Matsuda, Noritoshi Nishiyama
General Thoracic and Cardiovascular Surgery.2022; 70(1): 92. CrossRef
Un cas d’adénome muqueux glandulaire bronchique : un diagnostic rare à ne pas méconnaître !
Arnault Tauziède-Espariat, Bertrand Grand, Odette Georges, Ali Benali, Philippe Viehl, Laura Bitton, Gérard Antin, Albane Gareton, Raphaël Saffroy, René Jancovici, Diane Damotte
Annales de Pathologie.2021; 41(2): 192. CrossRef
Mucous Gland Adenoma: The Spectrum of Growth Patterns and the Diagnostic Challenges
Michael P. Zaleski, Neda Kalhor, Cesar A. Moran
Advances in Anatomic Pathology.2020; 27(6): 371. CrossRef
Peripheral mucous gland adenoma of the lung with parenchymal involvement and smooth muscle in the stroma
Xue-Ting Zhang, Man Yang, Xiao-Fang Liu, Xu-Yong Lin
Medicine.2018; 97(3): e9597. CrossRef
An unusual case of pulmonary hamartoma with predominant bronchial mucous glands in the peripheral lung
Rin Yamada, Akiko Tonooka, Shin‐ichiro Horiguchi, Toru Motoi, Hirotoshi Horio, Tsunekazu Hishima
Pathology International.2018; 68(7): 431. CrossRef

Fine Needle Aspiration Cytology of Warthin-like Papillary Thyroid Carcinoma: A Brief Case Report: Yosep Chong, Sungwook Suh, Tae-Jung Kim, Eun Jung Lee; Korean J Pathol. 2014;48(2):170-173. Published online April 28, 2014; DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.2.170

8,424 View
48 Download
13 Crossref

PDF

Citations

Citations to this article as recorded by

Cytological Characteristics of Warthin‐Like Papillary Carcinoma: A Report of Four Cases and Literature Review
Cao Ma, Xiaoying Wei, Zhe Chen, Lihua Zhang
Cytopathology.2025;[Epub] CrossRef
Warthin-like variant of papillary thyroid carcinoma with lymph node metastases: a case report and review of the literature
Andrii Hryshchyshyn, Andrii Bahrii, Pavlina Botsun, Volodymyr Chuba
Journal of Medical Case Reports.2024;[Epub] CrossRef
Warthin-like Papillary Thyroid Carcinoma: A Case Report and Review of the Literature
J. N. Aparnna, Pavithra Ayyanar, Mukund N. Sable, Dillip Kumar Samal, Amit Kumar Adhya, Pritinanda Mishra
International Journal of Surgical Pathology.2024;[Epub] CrossRef
Cytologic hallmarks and differential diagnosis of papillary thyroid carcinoma subtypes
Agnes Stephanie Harahap, Chan Kwon Jung
Journal of Pathology and Translational Medicine.2024; 58(6): 265. CrossRef
The Warthin-like variant of papillary thyroid carcinomas: a clinicopathologic analysis report of two cases
Xing Zhao, Yijia Zhang, Pengyu Hao, Mingzhen Zhao, Xingbin Shen
Oncologie.2023; 25(5): 581. CrossRef
Solid papillary thyroid carcinoma with Hashimoto’s thyroiditis: description of a further case with challenging cytological features
Franco Fulciniti, Jessica Barizzi, Pierpaolo Trimboli, Luca Giovanella
BMJ Case Reports.2019; 12(1): e226153. CrossRef
Preoperative Cytologic Diagnosis of Warthin-like Variant of Papillary Thyroid Carcinoma
Jisup Kim, Beom Jin Lim, Soon Won Hong, Ju Yeon Pyo
Journal of Pathology and Translational Medicine.2018; 52(2): 105. CrossRef
Warthin like papillary carcinoma - A rare variant of papillary carcinoma thyroid
Mir Wajahat, Tazeen Jeelani, Kanika Gupta, Nusrat Bashir
Human Pathology: Case Reports.2018; 13: 21. CrossRef
Cytological features of warthin‐like papillary thyroid carcinoma: A case report with review of previous cytology cases
Archana George Vallonthaiel, Shipra Agarwal, Deepali Jain, Rajni Yadav, Nishikant A. Damle
Diagnostic Cytopathology.2017; 45(9): 837. CrossRef
Comparison of EASYPREP® and SurePath® in thyroid fine‐needle aspiration
Yosep Chong, Ki Hyun Baek, Jee Young Kim, Tae‐Jung Kim, Eun Jung Lee, Chang Suk Kang
Diagnostic Cytopathology.2016; 44(4): 283. CrossRef
Ultrasonographic features and clinical characteristics of Warthin-like variant of papillary thyroid carcinoma
Ga Ram Kim, Jung Hee Shin, Soo Yeon Hahn, Eun Young Ko, Young Lyun Oh
Endocrine Journal.2016; 63(4): 329. CrossRef
Warthin-Like Papillary Thyroid Carcinoma Associated with Lymphadenopathy and Hashimoto’s Thyroiditis
Karla Judith González-Colunga, Abelardo Loya-Solis, Luis Ángel Ceceñas-Falcón, Oralia Barboza-Quintana, René Rodríguez-Gutiérrez
Case Reports in Endocrinology.2015; 2015: 1. CrossRef
Tumeur Warthin-like de la thyroïde : à propos d’un cas
W. Rekik, A. Khadhar, A. Zehani, H. Azouz, I. Chelly, T. Ben Ghachem, A. Sellem, M. Tounsi, H. Ben Mahjouba, S. Haouet, N. Kchir
Journal Africain du Cancer / African Journal of Cancer.2015; 7(4): 247. CrossRef

First
Prev
Page of 1
Next
Last

Previous issues