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Volume 48(3); June 2014
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Review
Current Concepts and Occurrence of Epithelial Odontogenic Tumors: II. Calcifying Epithelial Odontogenic Tumor Versus Ghost Cell Odontogenic Tumors Derived from Calcifying Odontogenic Cyst
Suk Keun Lee, Yeon Sook Kim
Korean J Pathol. 2014;48(3):175-187.   Published online June 26, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.3.175
  • 12,948 View
  • 265 Download
  • 26 Citations
AbstractAbstract PDF

Calcifying epithelial odontogenic tumors (CEOTs) and ghost cell odontogenic tumors (GCOTs) are characteristic odontogenic origin epithelial tumors which produce calcifying materials from transformed epithelial tumor cells. CEOT is a benign odontogenic tumor composed of polygonal epithelial tumor cells that show retrogressive calcific changes, amyloid-like deposition, and clear cytoplasm. Differentially, GCOTs are a group of transient tumors characterized by ghost cell presence, which comprise calcifying cystic odontogenic tumor (CCOT), dentinogenic ghost cell tumor (DGCT), and ghost cell odontogenic carcinoma (GCOC), all derived from calcifying odontogenic cysts (COCs). There is considerable confusion about COCs and GCOTs terminology, but these lesions can be classified as COCs or GCOTs, based on their cystic or tumorous natures, respectively. GCOTs include ameloblastomatous tumors derived from dominant odontogenic cysts classified as CCOTs, ghost cell-rich tumors producing dentinoid materials as DGCTs, and the GCOT malignant counterpart, GCOCs. Many authors have reported CEOTs and GCOTs variably express keratins, β-catenin, BCL-2, BSP, RANKL, OPG, Notch1, Jagged1, TGF-β, SMADs, and other proteins. However, these heterogeneous lesions should be differentially diagnosed to allow for accurate tumor progression and prognosis prediction.

Citations

Citations to this article as recorded by  
  • Immunohistochemical expression of Ki-67 and Glypican-3 to distinguish aggressive from nonaggressive benign odontogenic tumors
    TP Chaturvedi, Kanupriya Gupta, Rahul Agrawal, PG Naveen Kumar, Jatin Gupta
    Journal of Cancer Research and Therapeutics.2022; 18(9): 205.     CrossRef
  • A novel parotid carcinoma with a prominent ghost cell population: a masquerading tumor or “salivary ghost cell carcinoma”?
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    Medical Molecular Morphology.2022; 55(1): 76.     CrossRef
  • Ghost cells unveiled: A comprehensive review
    Aarushi Garg, Rewa Malhotra, Aadithya B. Urs
    Journal of Oral Biosciences.2022; 64(2): 202.     CrossRef
  • Ghost Cell Odontogenic Carcinoma Arising in a Previous Calcifying Odontogenic Cyst: A Case Report and Review of Literature
    Ioana Ghita, Michael Y. Nagai, Joshua E. Lubek, Kristen M. Stashek, John R. Basile, Jeffery B. Price, John C. Papadimitriou, Donita Dyalram, Rania H. Younis
    Head and Neck Pathology.2022; 16(3): 828.     CrossRef
  • Useful diagnostic histogenetic features of ectopic odontogenic ghost cell tumours
    Yuri Noda, Chisato Ohe, Mitsuaki Ishida, Kimiaki Okano, Kaori Sando, Naoya Hada, Yusuke Ebisu, Takuo Fujisawa, Masao Yagi, Hiroshi Iwai, Koji Tsuta
    BMC Oral Health.2022;[Epub]     CrossRef
  • Histopathologic Feature of Hyalinization Predicts Recurrence of Conventional/Solid Multicystic Ameloblastomas
    Dominic Augustine, Roopa S. Rao, Lakshminarayana Surendra, Shankargouda Patil, Thuckanaickenpalayam Ragunathan Yoithapprabhunath, Sarah Albogami, Shaheen Shamsuddin, Sulphi Abdul Basheer, Shan Sainudeen
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  • Multidisciplinary Case Management in Mesiodens Impacted Cases with Calcifying Odontogenic Cyst
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    Case Reports in Dentistry.2022; 2022: 1.     CrossRef
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    S. Höller, N. Rupp
    Der MKG-Chirurg.2021; 14(2): 96.     CrossRef
  • Dentinogenic Ghost Cell Tumor in a Sumatran Rhinoceros
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  • GHOST CELLS UNDER MICROSCOPE: A PERPLEXED HYPOTHESIS
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  • Ameloblastic fibro-odontoma in the mandible – Clinical, radiological and surgical aspect
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  • Calcifying odontogenic cysts: A 20-year retrospective clinical and radiological review
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    Dentomaxillofacial Radiology.2021; 50(6): 20200586.     CrossRef
  • Case report and review of calcifying epithelial odontogenic tumor
    Jayarathi Ishwarya K S, V. Ramesh, P. D. Balamurali, Karthikshree V Prashad
    International Journal of Oral Health Dentistry.2021; 7(3): 206.     CrossRef
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  • Differential diagnosis of ameloblastic fibro-odontoma: case report and literature review
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  • Odontogenic Cysts and Tumors
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    Annals of Plastic Surgery.2019; 82(4): 469.     CrossRef
  • Perfil clínico e histopatológico do cisto odontogênico calcificante: relato de caso
    Hugo Leite Rodrigues Neto, Daniel Amaral Alves Marlière, Marcelo Galindo Silvares, Luciana Asprino, Rodrigo Alvitos Pereira
    HU Revista.2019; 43(4): 415.     CrossRef
  • Ghost cell odontogenic carcinoma with suspected cholesterol granuloma of the maxillary sinus in a patient treated with combined modality therapy
    You Qin, Yanwei Lu, Liduan Zheng, Hong Liu
    Medicine.2018; 97(7): e9816.     CrossRef
  • Calcifying odontogenic cyst, dentinogenic ghost cell tumor, and ghost cell odontogenic carcinoma: A systematic review
    José Alcides Almeida de Arruda, João Luiz Gomes Carneiro Monteiro, Lucas Guimarães Abreu, Leni Verônica de Oliveira Silva, Lauren Frenzel Schuch, Mariana Saturnino de Noronha, Gerhilde Callou, Amália Moreno, Ricardo Alves Mesquita
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  • Glypican-3 distinguishes aggressive from non-aggressive odontogenic tumors: a preliminary study
    Ramon Barreto Mendes, Rosane Borges Dias, Andreia Leal Figueiredo, Clarissa Araújo Gurgel, Manoel Santana Filho, Leonardo Araújo Melo, Marília Trierveiler, Patrícia Ramos Cury, Rosalia Leonardi, Jean Nunes Dos Santos
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  • Ghost Cell Tumors
    Jason Sheikh, Molly D. Cohen, Naomi Ramer, Ali Payami
    Journal of Oral and Maxillofacial Surgery.2017; 75(4): 750.     CrossRef
  • Ghost cell odontogenic carcinoma on right mandible and its respective surgical reconstruction: a case report
    Sang Yoon Park, Joonhyoung Park, Do Hyun Kwon, Jae ho Jeon, Soung Min Kim, Hoon Myoung, Jong Ho Lee
    Journal of the Korean Association of Oral and Maxillofacial Surgeons.2017; 43(6): 415.     CrossRef
  • Histologic Variants of Calcifying Odontogenic Cyst: A Study of 52 Cases
    Soussan Irani, Forough Foroughi
    The Journal of Contemporary Dental Practice.2017; 18(8): 688.     CrossRef
  • Pediatric Odontogenic Cysts of the Jaws
    Kevin Arce, Christopher S. Streff, Kyle S. Ettinger
    Oral and Maxillofacial Surgery Clinics of North America.2016; 28(1): 21.     CrossRef
  • Metastatic Ghost Cell Odontogenic Carcinoma: Description of a Case and Search for Actionable Targets
    Maximilien J. Rappaport, Darion L. Showell, William J. Edenfield
    Rare Tumors.2015; 7(3): 96.     CrossRef
  • The Diagnostic Usefulness of Immunohistochemistry for Odontogenic Lesions
    Keith D. Hunter, Paul M. Speight
    Head and Neck Pathology.2014; 8(4): 392.     CrossRef
Original Articles
Extrapulmonary Lymphangioleiomyoma: Clinicopathological Analysis of 4 Cases
Dae Hyun Song, In Ho Choi, Sang Yun Ha, Kang Min Han, Jae Jun Lee, Min Eui Hong, Yoon-La Choi, Kee-Taek Jang, Sang Yong Song, Chin A Yi, Joungho Han
Korean J Pathol. 2014;48(3):188-192.   Published online June 26, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.3.188
  • 7,161 View
  • 54 Download
  • 8 Citations
AbstractAbstract PDF
Background

Lymphangioleiomyomatosis (LAM) is a slowly progressive neoplastic disease that predominantly affects females. Usually, LAM affects the lung; it can also affect extrapulmonary sites, such as the mediastinum, the retroperitoneum, or the lymph nodes, although these locations are rare. A localized form of LAM can manifest as extrapulmonary lesions; this form is referred to as extrapulmonary lymphangioleiomyoma (E-LAM). Due to the rare occurrence of E-LAM and its variable, atypical location, E-LAM is often difficult to diagnose. Herein, we report the clinicopathological information from four E-LAM cases, and also review previous articles investigating this disease.

Methods

Four patients with E-LAM were identified at the Samsung Medical Center (Seoul, Korea) from 1995 to 2012. All E-LAM lesions underwent surgical excision.

Results

All patients were females within the age range of 43 to 47 years. Two patients had para-aortic retroperitoneal masses, while the other two patients had pelvic lesions; two out of the four patients also had accompanying pulmonary LAM. In addition, no patient displayed any evidence of tuberous sclerosis. Histologically, two patients exhibited nuclear atypism with cytologic degeneration.

Conclusions

E-LAM should be considered in the differential diagnosis of patients presenting with pelvic or para-aortic masses. We also conclude that further clinical and pathological evaluation is needed in patients with E-LAM and nuclear atypism.

Citations

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    Aiko Ogasawara, Shogo Yamaguchi, Hiroaki Inui, Mieko Hanaoka, Daisuke Shintani, Sho Sato, Masanori Yasuda, Akira Yabuno
    JAPANESE JOURNAL OF GYNECOLOGIC AND OBSTETRIC ENDOSCOPY.2022; 38(1): 158.     CrossRef
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    BMJ Case Reports.2022; 15(11): e250466.     CrossRef
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    Jingshuo (Derek) Sun, Thomas Shum, Fardad Behzadi, Mark M. Hammer
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    BMJ Case Reports.2019; 12(2): e226358.     CrossRef
  • Summary of the Japanese Respiratory Society statement for the treatment of lung cancer with comorbid interstitial pneumonia
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Evaluation of Protein Expression in Housekeeping Genes across Multiple Tissues in Rats
Hye Jeong Kim, Jong In Na, Byung Woo Min, Joo Young Na, Kyung Hwa Lee, Jae Hyuk Lee, Young Jik Lee, Hyung Seok Kim, Jong Tae Park
Korean J Pathol. 2014;48(3):193-200.   Published online June 26, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.3.193
  • 10,727 View
  • 113 Download
  • 14 Citations
AbstractAbstract PDF
Background

Housekeeping genes, which show constant protein expression patterns between different tissue types, are very important in molecular biological studies as an internal control for protein research.

Methods

The protein expression profiles of seven housekeeping genes (HPRT1, PPIA, GYS1, TBP, YWHAZ, GAPDH and ACTB) in various rat tissues (cerebrum, cerebellum, cardiac ventricle and atrium, psoas muscle, femoral muscle, liver, spleen, kidney, and aorta) were analyzed by Western blot and compared by coefficient of variation (CV).

Results

HPRT1 was stably expressed (CV≤10%) in six tissues (cerebrum, cerebellum, ventricle, femoral muscle, spleen, and kidney), PPIA was stably expressed in five tissues (cerebrum, cerebellum, ventricle, spleen and kidney), YWHAZ was stably expressed in three tissues (cerebrum, cerebellum, and kidney), and GAPDH was stably expressed in four tissues (cerebrum, ventricle, psoas muscle, and kidney). In comparison, GYS1, TBP, and ACTB were found to have CV values over 10% in all tissues. Of the seven genes examined, four (HPRT1, PPIA, YWHAZ, and GAPDH) were found to be stably expressed across multiple organs, with low CV values (≤10%).

Conclusions

These results will provide fundamental information regarding internal controls for protein expression studies and can be used for analysis of postmortem protein degradation patterns in forensic medicine.

Citations

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Classic Papillary Thyroid Carcinoma with Tall Cell Features and Tall Cell Variant Have Similar Clinicopathologic Features
Woo Jin Oh, Young Sub Lee, Uiju Cho, Ja Seong Bae, Sohee Lee, Min Hee Kim, Dong Jun Lim, Gyeong Sin Park, Youn Soo Lee, Chan Kwon Jung
Korean J Pathol. 2014;48(3):201-208.   Published online June 26, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.3.201
  • 14,030 View
  • 114 Download
  • 29 Citations
AbstractAbstract PDF
Background

The tall cell variant of papillary thyroid carcinoma (TCVPTC) is more aggressive than classic papillary thyroid carcinoma (PTC), but the percentage of tall cells needed to diagnose TCVPTC remains controversial. In addition, little is known about the clinicopathologic features of classic PTC with tall cell features (TCF).

Methods

We retrospectively selected and reviewed the clinicopathologic features and presence of the BRAF mutation in 203 cases of classic PTC, 149 cases of classic PTC with TCF, and 95 cases of TCVPTCs, which were defined as PTCs having <10%, 10-50%, and ≥50% tall cells, respectively.

Results

TCVPTCs and classic PTCs with TCF did not vary significantly in clinicopathologic characteristics such as pathologic (p) T stage, extrathyroidal extension, pN stage, lateral lymph node metastasis, or BRAF mutations; however, these features differed significantly in TCVPTCs and classic PTCs with TCF in comparison to classic PTCs. Similar results were obtained in a subanalysis of patients with microcarcinomas (≤1.0 cm in size).

Conclusions

Classic PTCs with TCF showed a similar BRAF mutation rate and clinicopathologic features to TCVPTCs, but more aggressive characteristics than classic PTCs.

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    Uiju Cho, Ozgur Mete, Min-Hee Kim, Ja Seong Bae, Chan Kwon Jung
    Modern Pathology.2017; 30(6): 810.     CrossRef
  • BRAF-positive paucicellular variant of anaplastic carcinoma in the presence of tall cell variant papillary thyroid cancer
    O. V. Dolzhansky, E. M. Paltseva, D. N. Khmelkova, F. A. Konovalov, I. V. Kanivets, A. V. Lavrov, D. V. Pyankov, S. A. Korostelev, O. A. Levendyuk, V. M. Pominalnaya, D. N. Fedorov
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    Zeming Liu, Wen Zeng, Tianwen Chen, Yawen Guo, Chao Zhang, Chunping Liu, Tao Huang
    Oncotarget.2017; 8(4): 6222.     CrossRef
  • Clinical utility of TERT promoter mutations and ALK rearrangement in thyroid cancer patients with a high prevalence of the BRAF V600E mutation
    Ja Seong Bae, Yourha Kim, Sora Jeon, Se Hee Kim, Tae Jung Kim, Sohee Lee, Min-Hee Kim, Dong Jun Lim, Youn Soo Lee, Chan Kwon Jung
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    Xiaofei Wang, Wenli Cheng, Chongqing Liu, Jingdong Li
    Oncotarget.2016; 7(26): 40792.     CrossRef
  • The Warthin-Like Variant of Papillary Thyroid Carcinoma: A Comparison with Classic Type in the Patients with Coexisting Hashimoto’s Thyroiditis
    Min-kyung Yeo, Ja Seong Bae, Sohee Lee, Min-Hee Kim, Dong-Jun Lim, Youn Soo Lee, Chan Kwon Jung
    International Journal of Endocrinology.2015; 2015: 1.     CrossRef
  • BRAF Immunohistochemistry Using Clone VE1 is Strongly Concordant with BRAFV600E Mutation Test in Papillary Thyroid Carcinoma
    Jung-Soo Pyo, Jin Hee Sohn, Guhyun Kang
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  • Pathologie de la thyroïde. Cas no 3. Carcinome papillaire de la thyroïde, variante à cellules hautes
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Expression of CD99 in Multiple Myeloma: A Clinicopathologic and Immunohistochemical Study of 170 Cases
Su-Jin Shin, Hyangsin Lee, Geunyoung Jung, Minchan Gil, Hosub Park, Young Soo Park, Dok Hyun Yoon, Cheolwon Suh, Chan-Jeoung Park, Jooryung Huh, Chan-Sik Park
Korean J Pathol. 2014;48(3):209-216.   Published online June 26, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.3.209
  • 6,613 View
  • 53 Download
  • 8 Citations
AbstractAbstract PDF
Background

Multiple myeloma (MM) is a heterogeneous and ultimately fatal disease. Risk stratification using prognostic biomarkers is crucial to individualize treatments. We sought to investigate the role of CD99, a transmembrane protein highly expressed in many hematopoietic cells including subpopulations of normal and neoplastic plasma cells, for MM risk stratification.

Methods

CD99 expression was measured in paraffin samples of bone marrow and extramedullary biopsies of 170 patients with MM. Patients were divided into those with high score (moderately and strongly positive) and low score (negative and weakly positive), with all staining being cytoplasmic and/or membranous.

Results

High anti-CD99 immunostaining was observed in 72 of 136 (52.9%) bone marrow biopsies and 24 of 87 (27.6%) extramedullary biopsies in MM. High CD99 expression of extramedullary specimens was associated with significantly longer overall survival (OS; p=.016). High CD99 expression of extramedullary specimens was also associated with better prognosis in the nonautologous stem cell transplantation group of MM patients (p=.044). In multivariate analysis, International Staging System stage was an independent prognostic factor, whereas CD99 expression was no longer statistically significant.

Conclusions

Expression of CD99 in extramedullary specimens was correlated with longer OS, suggesting that CD99 may be a helpful immunohistochemical marker for risk stratification.

Citations

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  • Detection of Circulating Tumor Plasma Cells in Monoclonal Gammopathies: Methods, Pathogenic Role, and Clinical Implications
    Luzalba Sanoja-Flores, Juan Flores-Montero, Martín Pérez-Andrés, Noemí Puig, Alberto Orfao
    Cancers.2020; 12(6): 1499.     CrossRef
  • Tumor suppressor CD99 is downregulated in plasma cell neoplasms lacking CCND1 translocation and distinguishes neoplastic from normal plasma cells and B-cell lymphomas with plasmacytic differentiation from primary plasma cell neoplasms
    Qi Gao, Venkata Yellapantula, Maly Fenelus, Janine Pichardo, Lu Wang, Ola Landgren, Ahmet Dogan, Mikhail Roshal
    Modern Pathology.2018; 31(6): 881.     CrossRef
  • EWSR1 fusion proteins mediate PAX7 expression in Ewing sarcoma
    Gregory W Charville, Wei-Lien Wang, Davis R Ingram, Angshumoy Roy, Dafydd Thomas, Rajiv M Patel, Jason L Hornick, Matt van de Rijn, Alexander J Lazar
    Modern Pathology.2017; 30(9): 1312.     CrossRef
  • Activation of the polycomb repressive complex pathway in the bone marrow resident cells of diffuse large B-cell lymphoma patients
    Eun Ji Oh, Eun Kyung Kim, Woo Ick Yang, Sun Och Yoon
    Leukemia & Lymphoma.2016; 57(8): 1921.     CrossRef
  • CD99 Is Strongly Expressed in Basal Cells of the Normal Adult Epidermis and Some Subpopulations of Appendages: Comparison with Developing Fetal Skin
    Gawon Choi, Jin Roh, Chan-Sik Park
    Journal of Pathology and Translational Medicine.2016; 50(5): 361.     CrossRef
  • Towards Stratified Medicine in Plasma Cell Myeloma
    Philip Egan, Stephen Drain, Caroline Conway, Anthony Bjourson, H. Alexander
    International Journal of Molecular Sciences.2016; 17(10): 1760.     CrossRef
  • Human Myeloma Cell Lines Induce Osteoblast Downregulation of CD99 Which Is Involved in Osteoblast Formation and Activity
    Angela Oranger, Giacomina Brunetti, Claudia Carbone, Graziana Colaianni, Teresa Mongelli, Isabella Gigante, Roberto Tamma, Giorgio Mori, Adriana Di Benedetto, Marika Sciandra, Selena Ventura, Katia Scotlandi, Silvia Colucci, Maria Grano
    Journal of Immunology Research.2015; 2015: 1.     CrossRef
  • CD99 regulates CXCL12-induced chemotaxis of human plasma cells
    Minchan Gil, Hyo-Kyung Pak, A-Neum Lee, Seo-Jung Park, Yoonkyung Lee, Jin Roh, Hyunji Lee, Yoo-Sam Chung, Chan-Sik Park
    Immunology Letters.2015; 168(2): 329.     CrossRef
Mesenchymal Stromal Cells Promote Tumor Progression in Fibrosarcoma and Gastric Cancer Cells
Byunghoo Song, Bokyung Kim, Se-Ha Choi, Kyo Young Song, Yang-Guk Chung, Youn-Soo Lee, Gyeongsin Park
Korean J Pathol. 2014;48(3):217-224.   Published online June 26, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.3.217
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  • 8 Citations
AbstractAbstract PDF
Background

Extensive evidence has accumulated regarding the role of mesenchymal stromal cells (MSCs) in tumor progression, but the exact effects and mechanisms underlying this role remain unclear. We investigated the effects of MSC-associated tumor progression in MSC-sarcoma models and a gastric cancer metastatic model.

Methods

We conducted an in vitro growth kinetics assay and an in vivo tumor progression assay for sarcoma cells and gastric cancer cells in the presence or absence of MSCs.

Results

MSC-cocultured human fibrosarcoma cells (HT1080) showed accelerated growth compared with HT1080 alone (79- vs 37-fold change, p<.050). For HT1080, human MSC-coinjected tumors showed significantly greater and highly infiltrative growth compared to those of HT1080 alone (p=.035). For mouse fibrosarcoma cells (WEHI164), mouse MSC-coinjected tumors had greater volume than those of WEHI164 alone (p=.141). For rat sarcoma cells (RR1022), rat MSC-coinjected tumors exhibited greater volume and infiltrative growth than those of RR1022 alone (p=.050). For human gastric cancer cells (5FU), tumors of 5FU alone were compact, nodular in shape, and expansile with good demarcation and no definite lung metastatic nodules, whereas tumors grown in the presence of human MSCs showed highly desmoplastic and infiltrative growth and multiple lung metastasis.

Conclusions

We observed morphological evidence for MSC-associated tumor progression of fibrosarcomas and gastric cancer cells.

Citations

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  • Transition between canonical to non-canonical Wnt signaling during interactions between mesenchymal stem cells and osteosarcomas
    Asulin Masha, Ghedalia-Peled Noa Ben, Erez Ifat Cohen, Ventura Yvonne, Vago Razi
    Open Journal of Orthopedics and Rheumatology.2020; : 037.     CrossRef
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    F. Cheng, Z. Huang, Z. Li
    Techniques in Coloproctology.2019; 23(7): 613.     CrossRef
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    PAOLA A. FILOMENO, KYUNG-PHIL KIM, NARA YOON, IRAN RASHEDI, VICTOR DAYAN, RITA A. KANDEL, XING-HUA WANG, TANIA C. FELIZARDO, ELLIOT BERINSTEIN, SALOMEH JELVEH, ANDREA FILOMENO, JEFFREY A. MEDIN, PETER C. FERGUSON, ARMAND KEATING
    Cytotherapy.2018; 20(8): 1001.     CrossRef
  • Review article: mesenchymal stromal cell therapy for inflammatory bowel diseases
    C. Grégoire, C. Lechanteur, A. Briquet, É. Baudoux, F. Baron, E. Louis, Y. Beguin
    Alimentary Pharmacology & Therapeutics.2017; 45(2): 205.     CrossRef
  • Effect of hGC-MSCs from human gastric cancer tissue on cell proliferation, invasion and epithelial-mesenchymal transition in tumor tissue of gastric cancer tumor-bearing mice
    Lin Song, Xin Zhou, Hong-Jun Jia, Mei Du, Jin-Ling Zhang, Liang Li
    Asian Pacific Journal of Tropical Medicine.2016; 9(8): 796.     CrossRef
  • BMP9 inhibits the growth and migration of lung adenocarcinoma A549 cells in a bone marrow stromal cell-derived microenvironment through the MAPK/ERK and NF-κB pathways
    JING WANG, YAGUANG WENG, MINGHAO ZHANG, YA LI, MENGTIAN FAN, YANGLIU GUO, YANTING SUN, WANG LI, QIONG SHI
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    Ogunc Meral, Hamdi Uysal
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Case Studies
Well-Differentiated Papillary Mesothelioma of the Tunica Vaginalis: A Case Study and Review of the Literature
Seyda Erdogan, Arbil Acikalin, Handan Zeren, Gulfılız Gonlusen, Suzan Zorludemir, Volkan Izol
Korean J Pathol. 2014;48(3):225-228.   Published online June 26, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.3.225
  • 7,342 View
  • 56 Download
  • 12 Citations
AbstractAbstract PDF

Well-differentiated papillary mesothelioma is an uncommon tumor of the testes that usually presents as a hydrocele. Here, we present the case of one patient who did not have a history of asbestos exposure. The tumor was localized in the tunica vaginalis and was composed of three pedunculated masses macroscopically. Microscopically, branching papillary structures with focal coagulative necrosis were present. In addition to immunohistochemistry, simian virus 40 DNA was also tested by polymerase chain reaction. This report presents one case of this rare entity, its clinical and macroscopic features, and follow-up results.

Citations

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  • Well-differentiated Papillary Mesothelial Tumour of the Tunica Vaginalis Testis – A Rare Lesion, but one Pathologists Should Know About Two Patient Reports and a Review of the Literature
    Johannes Kläger, Felicitas Oberndorfer, Cristophe Brunel, Julian Veser, Eva Compérat
    International Journal of Surgical Pathology.2023; : 106689692211298.     CrossRef
  • A diagnostic approach to paratesticular lesions with tubulopapillary architecture: a series of 16 serous borderline tumors/low-grade serous carcinoma and 14 well-differentiated papillary mesothelial tumors and mesothelioma
    Rabia Zafar, Lacey J. Schrader, John C. Cheville, J. Kenneth Schoolmeester, Anja C. Roden, Marie-Christine Aubry, Eunhee S. Yi, Aditya Raghunathan, Loren Herrera-Hernandez, R. Houston Thompson, Stephen A. Boorjian, Bradley C. Leibovich, Gary L. Keeney, Ra
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  • Mesothelioma subtypes of the tunica vaginalis: a rare case report and review of histological criteria
    Cutts Rebecca, Martin J Connor, Luxi Sun, Thomas Johnston, Rachel Gooch, John McLoughlin
    Journal of Surgical Case Reports.2019;[Epub]     CrossRef
  • Well-differentiated papillary mesothelioma of tunica vaginalis testis of unknown malignant potential: Sonographic appearance
    K.W.S. Ko, K.S. Tse, K.W. Shek, M.N. Hau, S.H. Ting
    Journal of Clinical Ultrasound.2018; 46(5): 364.     CrossRef
  • Tunica Vaginalis Thickening, Hemorrhagic Infiltration and Inflammatory Changes in 8 Children with Primary Hydrocele; Reactive Mesothelial Hyperplasia? A Prospective Clinical Study
    Ioannis Patoulias, Evangelia Rachmani, Maria Kalogirou, Kyriakos Chatzopoulos, Dimitrios Patoulias
    Acta Medica (Hradec Kralove, Czech Republic).2018; 61(2): 41.     CrossRef
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    Sheetu Singh, Arpita Jindal
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  • Two Case Reports of Benign Testicular Mesothelioma and Review of the Literature
    Cristobal Ramirez Sevilla, Carme Admella Salvador, Josep Feliu Canaleta, Juan Llopis Manzanera, Miguel Angel Barranco Sanz, Juan Antoni Romero Martin, Sergi Bernal Salguero
    Case Reports in Oncological Medicine.2017; 2017: 1.     CrossRef
  • Well-differentiated Papillary Mesothelioma of the Tunica Vaginalis
    Wei Keith Tan, Mae-Yen Tan, Hui Meng Tan, Rajadurai Pathmanathan, Wei Phin Tan
    Urology.2016; 90: e7.     CrossRef
  • Well-Differentiated Papillary Mesothelioma of the Tunica Vaginalis: Case Report and Systematic Review of Literature
    Wei Keith Tan, Mae-Yen Tan, Wei Shen Tan, Soon Ching Gan, Rajadurai Pathmanathan, Hui Meng Tan, Wei Phin Tan
    Clinical Genitourinary Cancer.2016; 14(4): e435.     CrossRef
  • The legacy of the F344 rat as a cancer bioassay model (a retrospective summary of three common F344 rat neoplasms)
    Robert R. Maronpot, Abraham Nyska, Jennifer E. Foreman, Yuval Ramot
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  • Malignant Mesothelioma of the Tunica Vaginalis: A Rare Neoplasm—Case Report and Literature Review
    Manuel Segura-González, Jorge Urias-Rocha, Jorge Castelán-Pedraza
    Clinical Genitourinary Cancer.2015; 13(6): e401.     CrossRef
  • In vivo Optical Coherence Tomography Imaging of the Mesothelium Using Developed Window Models
    Yeh-Chan Ahn, Yu-Gyeong Chae, Sang Seok Hwang, Bong-Kwon Chun, Maan Hong Jung, Sung Jin Nam, Hae-Young Lee, Jae Min Chung, Chulho Oak, Eun-Kee Park
    Journal of the Optical Society of Korea.2015; 19(1): 69.     CrossRef
Low-Grade Adenosquamous Carcinoma of the Breast with Diverse Expression Patterns of Myoepithelial Cell Markers on Immunohistochemistry: A Case Study
Yoon Jin Cha, Gi Jeong Kim, Byeong-Woo Park, Ja Seung Koo
Korean J Pathol. 2014;48(3):229-233.   Published online June 26, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.3.229
  • 5,846 View
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  • 6 Citations
AbstractAbstract PDF

This paper reports a case of low-grade adenosquamous carcinoma (LGASC) arising in a 69-year-old woman, who presented with a 1-cm palpable mass on her right breast. Core needle biopsy diagnosed the mass as a fibroadenoma. After six months, the mass increased in size, and the patient received subsequent mammotome excision. On microscopic examination, bland-looking small glands were infiltrating into the fibrotic stroma with lymphocytic infiltrates at the periphery. Hematoxylin and eosin staining revealed relatively easily detectable myoepithelial cells along the outside in each of the glandular structures with variable degrees of squamous metaplasia. Based on histologic features, the patient was diagnosed with LGASC. LGASC is a rare variant of metaplastic carcinoma, which is characterized by a favorable prognosis. Due to the bland cytology and presence of myoepithelial cells, LGASC can be misdiagnosed as benign lesion. Additionally, inconsistent expression of myoepithelial markers could aid the diagnosis of LGASC.

Citations

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    Guillaume Bataillon, Laetitia Fuhrmann, Elodie Girard, Emanuelle Menet, Marick Laé, Mathieu Capovilla, Isabelle Treilleux, Laurent Arnould, Frederique Penault-Llorca, Roman Rouzier, Caterina Marchiò, Ivan Bieche, Anne Vincent-Salomon
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    Ryoko Oi, Ichiro Maeda, Yoshio Aida, Yukari Yabuki, Toru Nishikawa, Yoshihide Kanemaki, Koichiro Tsugawa, Masayuki Takagi
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  • Low-grade Adenosquamous Carcinoma of the Breast
    Haruko SAKAMOTO, Akihiko SHIMANA, Hideaki HORI, Kouki TOKUDA, Hitoshi TSUBOUCHI, Miki TAKENAKA, Rin YAMAGUCHI
    Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2017; 78(9): 1983.     CrossRef
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    Paula S. Ginter, Sandra J. Shin, Timothy M. D'Alfonso
    Archives of Pathology & Laboratory Medicine.2016; 140(7): 651.     CrossRef
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    J.L. Senger, P. Meiers, R. Kanthan
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    Yuan-Tzu Lan, Kuo-Hung Huang, Chien-An Liu, Ling-Chen Tai, Ming-Huang Chen, Yee Chao, Anna Fen-Yau Li, Shih-Hwa Chiou, Yi-Ming Shyr, Chew-Wun Wu, Wen-Liang Fang, Sheng-Nan Lu
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Anaplastic Transformation of Papillary Thyroid Carcinoma in a Young Man: A Case Study with Immunohistochemical and BRAF Analysis
Ji Hye Park, Hyeong Ju Kwon, Cheong Soo Park, SoonWon Hong
Korean J Pathol. 2014;48(3):234-240.   Published online June 26, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.3.234
  • 6,699 View
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  • 4 Citations
AbstractAbstract PDF

This study reports a case of anaplastic transformation from a well-differentiated thyroid carcinoma in a young patient. The first recurrent tissue contained poorly differentiated foci that revealed lower thyroglobulin, thyroid transcription factor 1 (TTF-1), and galectin-3 expression than the well-differentiated area. However there was no increased p53 or Ki-67 expression in the poorly differentiated foci, nor in the well-differentiated area. The tissue subsequently relapsed and revealed only anaplastic features, complete loss of thyroglobulin, TTF-1, and galectin-3 expression and revealed an increase in p53 and Ki-67 expression. The BRAF V600E and BRAF V600V mutation were found in the initially diagnosed papillary thyroid carcinoma and the poorly differentiated foci of the recurring papillary thyroid carcinoma; however, only the BRAF V600V mutation was found in the anaplastic carcinoma. These results suggest that overexpression of p53 and Ki-67 contributed to the anaplastic transformation. We also found that the BRAF type changed during the tumor relapse.

Citations

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  • Coexisting well-differentiated and anaplastic thyroid carcinoma in the same primary resection specimen: immunophenotypic and genetic comparison of the two components in a consecutive series of 13 cases and a review of the literature
    Moira Ragazzi, Federica Torricelli, Benedetta Donati, Alessia Ciarrocchi, Dario de Biase, Giovanni Tallini, Eleonora Zanetti, Alessandra Bisagni, Elisabetta Kuhn, Davide Giordano, Andrea Frasoldati, Simonetta Piana
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    Luca Hegedűs, Dominika Rittler, Tamás Garay, Paul Stockhammer, Ildikó Kovács, Balázs Döme, Sarah Theurer, Thomas Hager, Thomas Herold, Stavros Kalbourtzis, Agnes Bankfalvi, Kurt W. Schmid, Dagmar Führer, Clemens Aigner, Balázs Hegedűs
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  • EWSR1 rearrangement is a frequent event in papillary thyroid carcinoma and in carcinoma of the thyroid with Ewing family tumor elements (CEFTE)
    G. Oliveira, A. Polónia, J. M. Cameselle-Teijeiro, D. Leitão, S. Sapia, M. Sobrinho-Simões, C. Eloy
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    Rodrigo Mon, James Newlon
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A Case of Metastatic Angiosarcoma Diagnosed by Liquid-Based Preparation: Peculiar Cytoplasmic Changes
Min Jung Jung, Young Ok Kim
Korean J Pathol. 2014;48(3):241-247.   Published online June 26, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.3.241
  • 5,551 View
  • 35 Download
  • 3 Citations
AbstractAbstract PDF

Angiosarcoma with predominantly epithelioid features is a rare soft tissue neoplasm and the interpretation of its cytopathologic findings may be difficult. We report a case of metastatic angiosarcoma with predominantly epithelioid features diagnosed by liquid-based cytology. The cytopathologic findings in this case differed from those of the conventional preparation and we found a clean background, no hyperchromatic nuclei and several cytoplasmic changes, including intracytoplasmic vacuoles with peculiar shapes, juxtanuclear condensation and perinuclear clearing. Identification of these changes using liquid-based cytology supplemented with immunochemistry may be helpful in reaching a correct cytopathologic diagnosis.

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    Hirokazu Ogino, Makoto Tobiume, Kozo Kagawa, Hiroshi Kawano, Satoshi Sakaguchi, Atsuro Saijo, Daisuke Matsumoto, Hiromitsu Takizawa, Yuriko Morikawa, Yoshimi Bando, Hisatsugu Goto, Hiroshi Nokihara, Yasuhiko Nishioka
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    Yusuke Amano, Yukari Obana, Yoko Nakanishi, Ryusuke Tsujimura, Kayomi Wakamatsu, Fumiko Uemura, Yoshihisa Katsura, Masahiko Sugitani, Norimichi Nemoto
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Brief Case Reports
Bilateral Stafne Bone Cavity in the Anterior Mandible with Heterotopic Salivary Gland Tissue: A Case Report
Hyunchul Kim, Jae Yeon Seok, Sangho Lee, Jungsuk An, Na Rae Kim, Dong Hae Chung, Hyun Yee Cho, Seung Yeon Ha
Korean J Pathol. 2014;48(3):248-249.   Published online June 26, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.3.248
  • 11,038 View
  • 60 Download
  • 8 Citations
PDF

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    Mahdi Niknami, Azin Parsa, Zahra Khodadadi
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    Alaettin Koç, Cennet Neslihan Eroğlu, Ersen Bilgili
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    Johan K.M. Aps, Natasha Koelmeyer, Cina Yaqub
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    Ariyan S Araghi, Richard M Graham
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    Liu Liu, Byung Cheol Kang, Suk Ja Yoon, Jae Seo Lee, Sel Ae Hwang
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    Ioan Davies, Holly Boyes, James Wykes, Graham Smith
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    Ji-Young Song
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Dedifferentiated Solitary Fibrous Tumor of Thoracic Cavity
Jung Wook Yang, Dae Hyun Song, In Seok Jang, Gyung Hyuck Ko
Korean J Pathol. 2014;48(3):250-253.   Published online June 26, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.3.250
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  • 57 Download
  • 5 Citations
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    Hyung Kyu Park, Dan Bi Yu, Minjung Sung, Ensel Oh, Mingi Kim, Ji-Young Song, Mi-Sook Lee, Kyungsoo Jung, Ka-Won Noh, Sungbin An, Kyoung Song, Do-Hyun Nam, Yu Jin Kim, Yoon-La Choi
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