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Volume 48(2); April 2014
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Review
Current Concepts in Primary Effusion Lymphoma and Other Effusion-Based Lymphomas
Yoonjung Kim, Chan Jeong Park, Jin Roh, Jooryung Huh
Korean J Pathol. 2014;48(2):81-90.   Published online April 28, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.2.81
  • 10,447 View
  • 122 Download
  • 27 Citations
AbstractAbstract PDF

Primary effusion lymphoma (PEL) is a human herpes virus 8 (HHV8)-positive large B-cell neoplasm that presents as an effusion with no detectable tumor in individuals with human immunodeficiency virus infection or other immune deficiencies. PEL is an aggressive neoplasm with a poor prognosis. PEL cells show diverse morphologies, ranging from immunoblastic or plasmablastic to anaplastic. The immunophenotype of PEL is distinct, but its lineage can be misdiagnosed if not assessed thoroughly. PEL cells usually express CD45, lack B- and T-cell-associated antigens, and characteristically express lymphocyte activation antigens and plasma cell-associated antigens. Diagnosis of PEL often requires the demonstration of a B-cell genotype. HHV8 must be detected in cells to diagnose PEL. In most cases, PEL cells also harbor the Epstein-Barr virus (EBV) genome. Similar conditions associated with HHV8 but not effusion-based are called "extracavitary PELs." PELs should be differentiated from HHV8-negative, EBV-positive, body cavity-based lymphomas in patients with long-standing chronic inflammation; the latter can occur in tuberculous pleuritis, artificial pneumothorax, chronic liver disease and various other conditions. Despite their morphological similarity, these various lymphomas require different therapeutic strategies and have different prognostic implications. Correct diagnosis is essential to manage and predict the outcome of patients with PEL and related disorders.

Citations

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    Chih-Yi Liu, Bo-Jung Chen, Shih-Sung Chuang
    Diagnostics.2022; 12(3): 713.     CrossRef
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    Journal of Pathology and Translational Medicine.2022; 56(4): 173.     CrossRef
  • Clinical Characteristics and Management of Patients With Concomitant Liver Cirrhosis and Lymphoma: A Systematic Review
    Jelena Jelicic, Thomas Stauffer Larsen, Annette Dam Fialla, Zoran Bukumiric, Bosko Andjelic
    Clinical Lymphoma Myeloma and Leukemia.2022; 22(11): e981.     CrossRef
  • HHV8-unrelated primary effusion lymphoma: Two case reports and a review of literature
    Ryan W. Kendall, Ricky A. Thompson, Christopher P. Garwacki, Alan Z. Skarbnik
    Current Problems in Cancer: Case Reports.2021; 4: 100087.     CrossRef
  • Targeting Host Cellular Factors as a Strategy of Therapeutic Intervention for Herpesvirus Infections
    Kumari Asha, Neelam Sharma-Walia
    Frontiers in Cellular and Infection Microbiology.2021;[Epub]     CrossRef
  • A Rare Case of Extracavitary Primary Effusion Lymphoma in the Bladder and Ureter
    Jiankun Tong, Sana Jadallah, William H. Rodgers, Gabriel Jung, Malvina Fulman, Abhisek Swaika
    Case Reports in Hematology.2020; 2020: 1.     CrossRef
  • KSHV: Immune Modulation and Immunotherapy
    Grant Broussard, Blossom Damania
    Frontiers in Immunology.2020;[Epub]     CrossRef
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    Priyanka Rai, Chandni Krishnani, Goswami S. S.
    Journal of Evolution of Medical and Dental Sciences.2020; 9(16): 1331.     CrossRef
  • Brentuximab vedotin as frontline treatment for HIV-related extracavitary primary effusion lymphoma
    Jose D. Sandoval-Sus, Amanda Brahim, Alina Khan, Barbara Raphael, Ali Ansari-Lari, Marco Ruiz
    International Journal of Hematology.2019; 109(5): 622.     CrossRef
  • High-dose Therapy and Autologous Hematopoietic Cell Transplantation as Consolidation Treatment for Primary Effusion Lymphoma
    Abu-Sayeef Mirza, Bhagirathbhai R. Dholaria, Mohammad Hussaini, Sarah Mushtaq, Pedro Horna, Adharsh Ravindran, Ambuj Kumar, Ernesto Ayala, Mohamed A. Kharfan-Dabaja, Celeste Bello, Julio C. Chavez, Lubomir Sokol
    Clinical Lymphoma Myeloma and Leukemia.2019; 19(9): e513.     CrossRef
  • Remission of an HHV8-related extracavitary primary effusion lymphoma in an HIV-positive patient during antiretroviral treatment containing dolutegravir
    Laura Campogiani, Carlotta Cerva, Gaetano Maffongelli, Elisabetta Teti, Livio Pupo, Sara Vaccarini, Maria Cantonetti, Alfredo Pennica, Massimo Andreoni, Loredana Sarmati
    AIDS Research and Therapy.2019;[Epub]     CrossRef
  • Primary Effusion Lymphoma in a Non-Human Immunodeficiency Virus Patient: A Case Report
    Beum Jin Kim, Mi Sook Lee
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  • Pleural effusion in a human immunodeficiency virus‐infected patient
    Rafael Martínez‐Girón, Santiago Martínez‐Torre
    Cytopathology.2019; 30(6): 673.     CrossRef
  • Case report of a primary effusion lymphoma successfully treated with oral valganciclovir after failing chemotherapy
    Juan Marquet, Kyra Velazquez-Kennedy, Sandra López, Amparo Benito, María-Jesús Blanchard, Jose Antonio Garcia-Vela
    Hematological Oncology.2018; 36(1): 316.     CrossRef
  • Primary effusion lymphoma in Taiwan shows two distinctive clinicopathological subtypes with rare human immunodeficiency virus association
    Bo-Jung Chen, Ran-Ching Wang, Chung-Han Ho, Chang-Tsu Yuan, Wan-Ting Huang, Sheau-Fang Yang, Pin-Pen Hsieh, Yun-Chih Yung, Shih-Yao Lin, Chen-Fang Hsu, Ying-Zhen Su, Chun-Chi Kuo, Shih-Sung Chuang
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  • Effusion-based lymphoma with morphological regression but with clonal genetic features after aspiration
    Meng-Chen Tsai, Chun-Chi Kuo, Ying-Zhen Su, Yen-Chuan Hsieh, Shih-Sung Chuang
    Diagnostic Cytopathology.2018; 46(8): 685.     CrossRef
  • Biology and management of primary effusion lymphoma
    Kazuyuki Shimada, Fumihiko Hayakawa, Hitoshi Kiyoi
    Blood.2018; 132(18): 1879.     CrossRef
  • EBV-associated but HHV8-unrelated double-hit effusion-based lymphoma
    Bo-Jung Chen, David Yen-Ting Chen, Chun-Chi Kuo, Shih-Sung Chuang
    Diagnostic Cytopathology.2017; 45(3): 257.     CrossRef
  • HHV8/KSHV-Positive Lymphoproliferative Disorders and the Spectrum of Plasmablastic and Plasma Cell Neoplasms
    Amy Chadburn, Jonathan Said, Dita Gratzinger, John K. C. Chan, Daphne de Jong, Elaine S. Jaffe, Yasodha Natkunam, John R. Goodlad
    American Journal of Clinical Pathology.2017; 147(2): 171.     CrossRef
  • Human immunodeficiency virus (HIV) and Epstein-Barr virus (EBV) related lymphomas, pathology view point
    Ebru Linke-Serinsöz, Falko Fend, Leticia Quintanilla-Martinez
    Seminars in Diagnostic Pathology.2017; 34(4): 352.     CrossRef
  • Anticancer drug-loaded quantum dots engineered polymeric nanoparticles: Diagnosis/therapy combined approach
    D. Belletti, G. Riva, M. Luppi, G. Tosi, F. Forni, M.A. Vandelli, B. Ruozi, F. Pederzoli
    European Journal of Pharmaceutical Sciences.2017; 107: 230.     CrossRef
  • CD20-negative diffuse large B cell lymphoma: a comprehensive analysis of 695 cases
    Jing Li, Shu Zhao, Jingxuan Wang, Jingyu Chen, Wen Wen, Qingyuan Zhang
    Tumor Biology.2016; 37(3): 3619.     CrossRef
  • Co-infections and Pathogenesis of KSHV-Associated Malignancies
    Suhani Thakker, Subhash C. Verma
    Frontiers in Microbiology.2016;[Epub]     CrossRef
  • Pathology of Extranodal Lymphoma
    Emily Heckendorn, Aaron Auerbach
    Radiologic Clinics of North America.2016; 54(4): 639.     CrossRef
  • 2015 update on the diagnosis and management of neoplastic pericardial disease
    Chiara Lestuzzi, Massimiliano Berretta, Witold Tomkowski
    Expert Review of Cardiovascular Therapy.2015; 13(4): 377.     CrossRef
  • CD20-negative diffuse large B-cell lymphomas: biology and emerging therapeutic options
    Jorge J Castillo, Julio C Chavez, Francisco J Hernandez-Ilizaliturri, Santiago Montes-Moreno
    Expert Review of Hematology.2015; 8(3): 343.     CrossRef
  • Primary Effusion Lymphoma: Cytological Diagnosis of a Rare Entity - Report of Two Cases in HIV-Uninfected Patients from a Single Institution
    Marta Nicola, Monica Onorati, Chiara Luisa Bianchi, Giuseppe Pepe, Stefano Bellone, Franca Di Nuovo
    Acta Cytologica.2015; 59(5): 425.     CrossRef
Original Articles
Pleural Mesothelioma: An Institutional Experience of 66 Cases
Soomin Ahn, In Ho Choi, Joungho Han, Jhingook Kim, Myung-Ju Ahn
Korean J Pathol. 2014;48(2):91-99.   Published online April 28, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.2.91
  • 7,109 View
  • 62 Download
  • 2 Citations
AbstractAbstract PDF
Background

Malignant mesothelioma of the pleura is an aggressive tumor known to be associated with asbestos. Histological diagnosis of mesothelioma is challenging and is usually aided by immunohistochemical markers.

Methods

During an 18-year period (1995-2012), 66 patients with pleural mesothelioma were diagnosed at the Samsung Medical Center in Seoul. We reviewed hematoxylin and eosin and immunohistochemical slides of pleural mesothelioma and evaluated their pathological and clinical features.

Results

The male-to-female ratio was 1.75:1, and age of patients ranged from 28 to 80 years with an average age of 56.84 years. Twenty-two out of 66 patients underwent curative pneumonectomy. Follow-up data was available in 60 patients (90.9%), and 50 of them (83.3%) died from the disease. The average overall survival was 15.39 months. Histologically, the epithelioid type was the most common, followed by the sarcomatoid and the biphasic types. Epidemiologic information was not available in most cases, and only one patient was confirmed to have a history of asbestos exposure.

Conclusions

Malignant mesothelioma of the pleura is a fatal tumor, and the therapeutic benefit of pneumonectomy remains unproven. The combination of calretinin, Wilms tumor 1, HMBE-1, and thyroid transcription factor-1 may provide high diagnostic accuracy in diagnosing mesothelioma.

Citations

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  • Expression of V-set immunoregulatory receptor in malignant mesothelioma
    Yeon Seung Chung, Moonsik Kim, Yoon Jin Cha, Kyung A Kim, Hyo Sup Shim
    Modern Pathology.2020; 33(2): 263.     CrossRef
  • Is the pathology related to the amount of pleural thickening measured by thorax CT?
    özgür katrancıoğlu, Tuba Sahinoglu, Kayhan Karakus, Ozan Kandemir, Semiha Urvay, Esra Aydın Karakaya, Nurkay Katrancioglu
    Cumhuriyet Medical Journal.2018; 40(2): 157.     CrossRef
KRAS Mutation Detection in Non-small Cell Lung Cancer Using a Peptide Nucleic Acid-Mediated Polymerase Chain Reaction Clamping Method and Comparative Validation with Next-Generation Sequencing
Boram Lee, Boin Lee, Gangmin Han, Mi Jung Kwon, Joungho Han, Yoon-La Choi
Korean J Pathol. 2014;48(2):100-107.   Published online April 28, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.2.100
  • 10,548 View
  • 89 Download
  • 16 Citations
AbstractAbstract PDF
Background

KRAS is one of commonly mutated genetic "drivers" in non-small cell lung cancers (NSCLCs). Recent studies indicate that patients with KRAS-mutated tumors do not benefit from adjuvant chemotherapy, so there is now a focus on targeting KRAS-mutated NSCLCs. A feasible mutation detection method is required in order to accurately test for KRAS status.

Methods

We compared direct Sanger sequencing and the peptide nucleic acid (PNA)-mediated polymerase chain reaction (PCR) clamping method in 134 NSCLCs and explored associations with clinicopathological factors. Next-generation sequencing (NGS) was used to validate the results of discordant cases. To increase the resolution of low-level somatic mutant molecules, PNA-mediated PCR clamping was used for mutant enrichment prior to NGS.

Results

Twenty-one (15.7%) cases were found to have the KRAS mutations using direct sequencing, with two additional cases by the PNA-mediated PCR clamping method. The frequencies of KRAS mutant alleles were 2% and 4%, respectively, using conventional NGS, increasing up to 90% and 89%, using mutant-enriched NGS. The KRAS mutation occurs more frequently in the tumors of smokers (p=.012) and in stage IV tumors (p=.032).

Conclusions

Direct sequencing can accurately detect mutations, but, it is not always possible to obtain a tumor sample with sufficient volume. The PNA-mediated PCR clamping can rapidly provide results with sufficient sensitivity.

Citations

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    Ullas Batra, Shrinidhi Nathany, Mansi Sharma, Amrith BP, Joslia T. Jose, Harkirat Singh, Sakshi Mattoo, Anurag Mehta
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    Soo-Jin Kim, Eunhee Kim, Kyung-Taek Rim
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    Hyo Sup Shim, Yoon-La Choi, Lucia Kim, Sunhee Chang, Wan-Seop Kim, Mee Sook Roh, Tae-Jung Kim, Seung Yeon Ha, Jin-Haeng Chung, Se Jin Jang, Geon Kook Lee
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    Soomin Ahn, Soo Hyun Hwang, Joungho Han, Yoon-La Choi, Se-Hoon Lee, Jin Seok Ahn, Keunchil Park, Myung-Ju Ahn, Woong-Yang Park
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    Mi Jung Kwon, Jang Yong Jeon, Hye-Rim Park, Eun Sook Nam, Seong Jin Cho, Hyung Sik Shin, Ji Hyun Kwon, Joo Seop Kim, Boram Han, Dong Hoon Kim, Yoon-La Choi
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IMP3, a Promising Prognostic Marker in Clear Cell Renal Cell Carcinoma
Ji Young Park, Misun Choe, Yuna Kang, Sang Sook Lee
Korean J Pathol. 2014;48(2):108-116.   Published online April 28, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.2.108
  • 6,376 View
  • 32 Download
  • 2 Citations
AbstractAbstract PDF
Background

Insulin-like growth factor II mRNA-binding protein 3 (IMP3) has been reported as a prognostic biomarker in various cancers. To validate IMP3 as a prognostic biomarker in renal cell carcinoma (RCC), we investigated the expression of IMP3, p53, and Ki-67, and their associations with clinicopathologic outcomes.

Methods

We studied 148 clear cell RCCs (CCRCCs) from patients who underwent radical nephrectomy. The expression levels of IMP3, p53, and Ki-67 were assessed by immunohistochemical staining and the clinical and pathologic parameters were retrospectively reviewed.

Results

Twenty-nine percent of CCRCCs expressed IMP3. Forty-one percent of IMP3-immunopositive tumors developed metastases, while only 11.4% of IMP3-negative tumors developed metastases (p<.001). A Kaplan-Meier curve showed that patients with IMP3-immunopositive tumors had lower metastasis-free survival and cancer-specific survival than did those with IMP3-immunonegative tumors (p<.001 and p<.001, respectively). Expression of high Ki-67 proliferation index was also associated with a higher metastatic rate. In the multivariate Cox regression analysis, pT stage and IMP3-positivity were independently associated with disease-specific survival.

Conclusions

IMP3 is an independent prognostic biomarker for patients with CCRCC to predict metastasis and poor outcome.

Citations

Citations to this article as recorded by  
  • Prognostic value of insulin‑like growth factor 2 mRNA‑binding protein 3 and vascular endothelial growth factor‑A in patients with primary non‑small‑cell lung cancer
    Jiannan Liu, Ying Liu, Wenjing Gong, Xiangshuo Kong, Congcong Wang, Shuhua Wang, Aina Liu
    Oncology Letters.2019;[Epub]     CrossRef
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    Shuping You, Yun Guan, Weihong Li
    Molecular Medicine Reports.2017;[Epub]     CrossRef
Tumor Sprouting in Papillary Thyroid Carcinoma Is Correlated with Lymph Node Metastasis and Recurrence
Eunjung Lee, Wonkyung Jung, Jeong-Soo Woo, Jae Bok Lee, Bong Kyung Shin, Han Kyeom Kim, Aeree Kim, Baek-hui Kim
Korean J Pathol. 2014;48(2):117-125.   Published online April 28, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.2.117
  • 8,507 View
  • 55 Download
  • 5 Citations
AbstractAbstract PDF
Background

Identification of poor prognostic factors in papillary thyroid carcinoma (PTC) patients is important for the patients' care and follow-up. We can sometimes see small tumor clusters without desmoplasia and no evidence of lymphatic emboli around the main tumor mass of PTC. We termed this form of tumor clustering, 'tumor sprouting,' and determined whether these tumors correlate with lymphovascular invasion, lymph node metastasis, and recurrence.

Methods

We analyzed a total of 204 cases of papillary thyroid macrocarcinoma. Number, size and distance from the main tumor of the tumor sprouting were observed and analyzed with clinicopathologic characteristics.

Results

Tumor sprouting was observed in 101 patients. Presence of tumor sprouting was significantly associated with positive resection margin (p=.002), lymphovascular invasion (p=.001), lymph node metastasis (p<.001), and recurrence (p=.004). Univariate analysis of recurrence-free survival revealed that tumor multiplicity (p=.037), positive resection margin (p=.007), lymphovascular invasion (p=.004), lymph node metastasis (p<.001), and tumor sprouting (p=.004) were poor prognostic factors. In multivariate analysis, positive resection margin was an independent poor prognostic factor of recurrence.

Conclusions

In conclusion, tumor sprouting is significantly correlated with lymph node metastasis and recurrence. Evaluation of tumor sprouting in PTC patients could be helpful in predicting tumor recurrence or lymph node metastasis.

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    Huy Gia Vuong, Tetsuo Kondo, Uyen N P Duong, Thong Quang Pham, Naoki Oishi, Kunio Mochizuki, Tadao Nakazawa, Lewis Hassell, Ryohei Katoh
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Characteristics of Cutaneous Lymphomas in Korea According to the New WHO-EORTC Classification: Report of a Nationwide Study
Jae Ho Han, Young-Hyeh Ko, Yun Kyung Kang, Wan-Seop Kim, Yoon Jung Kim, Insun Kim, Hyun-Jung Kim, Soo Kee Min, Chan-Kum Park, Chan-Sik Park, Bong-Kyung Shin, Woo Ick Yang, Young-Ha Oh, Jong Sil Lee, Juhie Lee, Tae Hui Lee, Hyekyung Lee, Ho Jung Lee, Yoon Kyung Jeon, Hee Jeong Cha, Yoo-Duk Choi, Chul Woo Kim
Korean J Pathol. 2014;48(2):126-132.   Published online April 28, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.2.126
  • 7,123 View
  • 77 Download
  • 10 Citations
AbstractAbstract PDF
Background

Previously, cutaneous lymphomas were classified according to either the European Organization for the Research and Treatment of Cancer (EORTC) or the World Health Organization (WHO) classification paradigms. The aim of this study was to determine the relative frequency of Korean cutaneous lymphoma according to the new WHO-EORTC classification system.

Methods

A total of 517 patients were recruited during a recent 5 year-period (2006-2010) from 21 institutes and classified according to the WHO-EORTC criteria.

Results

The patients included 298 males and 219 females, and the mean age at diagnosis was 49 years. The lesions preferentially affected the trunk area (40.2%). The most frequent subtypes in order of decreasing prevalence were mycosis fungoides (22.2%), peripheral T-cell lymphoma (17.2%), CD30+ T-cell lymphoproliferative disorder (13.7%), and extranodal natural killer/T (NK/T) cell lymphoma, nasal type (12.0%). Diffuse large B-cell lymphoma accounted for 11.2% of cases, half of which were secondary cutaneous involvement; other types of B-cell lymphoma accounted for less than 1% of cases.

Conclusions

In comparison with data from Western countries, this study revealed relatively lower rates of mycosis fungoides and B-cell lymphoma in Korean patients, as well as higher rates of subcutaneous panniculitis-like T-cell lymphoma and NK/T cell lymphoma.

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    Cynthia M. Magro, Luke C. Olson, Shabnam Momtahen
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    In Sook Lee, You Seon Song, Seung Hyun Lee, Young Jin Choi, Sung Moon Lee
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Incidence and Malignancy Rates of Diagnoses in the Bethesda System for Reporting Thyroid Aspiration Cytology: An Institutional Experience
Ji Hye Park, Sun Och Yoon, Eun Ju Son, Hye Min Kim, Ji Hae Nahm, SoonWon Hong
Korean J Pathol. 2014;48(2):133-139.   Published online April 28, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.2.133
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AbstractAbstract PDF
Background

The Bethesda System for Reporting Thyroid Cytopathology (BSRTC) uses six diagnostic categories to standardize communication of thyroid fine-needle aspiration (FNA) interpretations between clinicians and cytopathologists. Since several studies have questioned the diagnostic accuracy of this system, we examined its accuracy in our hospital.

Methods

We calculated the incidences and malignancy rates of each diagnostic category in the BSRTC for 1,730 FNAs that were interpreted by four cytopathologists in Gangnam Severance Hospital between October 1, 2011, and December 31, 2011.

Results

The diagnostic incidences of categories I-VI were as follows: 13.3%, 40.6%, 9.1%, 0.4%, 19.3%, and 17.3%, respectively. Similarly, the malignancy rates of these categories were as follows: 35.3%, 5.6%, 69.0%, 50.0%, 98.7%, and 98.9%, respectively. In categories II, V, and VI, there were no statistically significant differences in the ranges of the malignancy rates among the four cytopathologists. However, there were significant differences in the ranges for categories I and III.

Conclusions

Our findings suggest that institutions that use the BSRTC should regularly update their diagnostic criteria. We also propose that institutions issue an annual report of incidences and malignancy rates to help other clinicians improve the case management of patients with thyroid nodules.

Citations

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    Ayca TAN
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Case Studies
Follicular Dendritic Cell Sarcoma of the Inflammatory Pseudotumor-like Variant Presenting as a Colonic Polyp
Shien-Tung Pan, Chih-Yuan Cheng, Nie-Sue Lee, Peir-In Liang, Shih-Sung Chuang
Korean J Pathol. 2014;48(2):140-145.   Published online April 28, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.2.140
  • 7,671 View
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  • 24 Citations
AbstractAbstract PDF

Follicular dendritic cell (FDC) sarcoma is rare and is classified either as conventional type or inflammatory pseudotumor (IPT)-like variant. Extranodal presentation is uncommon and nearly all gastrointestinal FDC tumors are of the conventional type. IPT-like variant tumors occur almost exclusively in the liver and spleen and are consistently associated with Epstein-Barr virus (EBV). Here we report the case of a 78-year-old woman with an IPT-like FDC sarcoma presenting as a pedunculated colonic polyp. Histologically, scanty atypical ovoid to spindle cells were mixed with a background of florid lymphoplasmacytic infiltrate, which led to an initial misdiagnosis of pseudolymphoma. These atypical cells expressed CD21, CD23, CD35, and D2-40, and were positive for EBV by in situ hybridization, confirming the diagnosis. The patient was free of disease five months after polypectomy without adjuvant therapy. Although extremely rare, the differential diagnosis for colonic polyp should include FDC sarcoma to avoid an erroneous diagnosis. A review of the 24 cases of IPT-like FDC sarcoma reported in the literature reveal that this tumor occurs predominantly in females with a predilection for liver and spleen, and has a strong association with EBV.

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Multifocal Osteosarcoma of the Skull: Multiple Primary or Metastatic? A Case Report
Hyuck Cho, Bong-jin Park, Yong-Koo Park
Korean J Pathol. 2014;48(2):146-150.   Published online April 28, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.2.146
  • 6,604 View
  • 44 Download
  • 6 Citations
AbstractAbstract PDF

Osteosarcoma of the skull is a very rare condition. Moreover, it is extremely rare for osteosarcoma to present as multiple lesions confined to the skull. A 58-year-old woman was admitted with two masses in the parietal area of the skull, accompanied by mild headache and tenderness. Imaging revealed two masses with a heterogeneous consistency in the cranial bones. Excision craniectomy was performed and the pathology was consistent with osteoblastic osteosarcoma. Two nodules in the heart were found on routine follow-up imaging while the patient was undergoing chemotherapy. The nodules were biopsied and found to be metastatic osteosarcoma.

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Different Protein Expressions between Peripheral Ameloblastoma and Oral Basal Cell Carcinoma Occurred at the Same Mandibular Molar Area
Yeon Sook Kim, Suk Keun Lee
Korean J Pathol. 2014;48(2):151-158.   Published online April 28, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.2.151
  • 7,364 View
  • 59 Download
  • 3 Citations
AbstractAbstract PDF

Peripheral ameloblastoma (PA) in gingiva is rare and often confused with oral basal cell carcinoma (OBCC). The tissues of one case of PA and one case of OBCC with the same mandibular molar area affected were compared via an immunohistochemical examination using 50 antisera. The PA and OBCC showed similar proliferation of basaloid epithelial strands, but toluidine blue staining revealed that the PA had pinkish juxta-epithelial myxoid tissue, whereas the OBCC was infiltrated by many mast cells. Immunohistochemical comparisons showed that the PA was strongly positive for ameloblastin, KL1, p63, carcinoembryonic antigen, focal adhesion kinase, and cathepsin K, and slightly positive for amelogenin, Krox-25, E-cadherin, and PTCH1, whereas the OBCC was not. On the other hand, the OBCC was strongly positive for EpCam, matrix metalloprotease (MMP)-1, α1-antitrypsin, cytokeratin-7, p53, survivin, pAKT1, transforming growth factor-β1, NRAS, TGase-1, and tumor nescrosis factor-α, and consistently positive for β-catenin, MMP-2, cathepsin G, TGase-2, SOS-1, sonic hedgehog, and the β-defensins-1, -2, -3, while the PA was not. These data suggest that the tumorigeneses of PA and OBCC differ, and that PAs undergo odontogenic differentiation and generate oncogenic signals for infiltrative growth and bone resorption, whereas OBCCs undergo basaloid epidermal differentiation as a result of growth factor/cytokine-related oncogenic signals.

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Brief Case Reports
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Korean J Pathol. 2014;48(2):159-161.   Published online April 28, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.2.159
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  • 42 Download
  • 7 Citations
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Korean J Pathol. 2014;48(2):162-163.   Published online April 28, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.2.162
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  • 36 Download
  • 2 Citations
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JPTM : Journal of Pathology and Translational Medicine