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Immunohistochemistry for Pathologists: Protocols, Pitfalls, and Tips
So-Woon Kim, Jin Roh, Chan-Sik Park
J Pathol Transl Med. 2016;50(6):411-418.   Published online October 13, 2016
DOI: https://doi.org/10.4132/jptm.2016.08.08
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AbstractAbstract PDF
Immunohistochemistry (IHC) is an important auxiliary method for pathologists in routine diagnostic work as well as in basic and clinical research including exploration of biomarkers, as IHC allows confirmation of target molecule expressions in the context of microenvironment. Although there has been a considerable progress in automation and standardization of IHC, there are still many things to be considered in proper optimization and appropriate interpretation. In this review, we aim to provide possible pitfalls and useful tips for practicing pathologists and residents in pathology training. First, general procedure of IHC is summarized, followed by pitfalls and tips in each step and a summary of troubleshooting. Second, ways to an accurate interpretation of IHC are discussed, with introduction to general quantification and analysis methods. This review is not intended to provide complete information on IHC, but to be used as a basic reference for practice and publication.

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    Inflammopharmacology.2022; 30(3): 961.     CrossRef
  • A Toolkit for Profiling the Immune Landscape of Pediatric Central Nervous System Malignancies
    Jacob S. Rozowsky, Joyce I. Meesters-Ensing, Julie A. S. Lammers, Muriël L. Belle, Stefan Nierkens, Mariëtte E. G. Kranendonk, Lennart A. Kester, Friso G. Calkoen, Jasper van der Lugt
    Frontiers in Immunology.2022;[Epub]     CrossRef
  • The histological and microbiological characteristics of bacterial microcolonies in paediatric tonsillar hyperplasia
    Ruyan Chen, Sita Tarini Clark, Sharon Waldvogel-Thurlow, Fiona Jane Radcliff, Michael Leigh Hoggard, James Johnston, Richard George Douglas, Kristi Biswas
    International Journal of Pediatric Otorhinolaryngology.2022; 157: 111128.     CrossRef
  • Hepatoprotective activity of Picrorhiza kurroa and Berberis lycium is mediated by inhibition of COX-2 and TGF-β expression in lantadenes-induced sub-chronic toxicity in guinea pigs
    Punam Soren, Rinku Sharma, Gorakh Mal, Bikram Singh, Pawan Kumar, Rajendra Damu Patil, Birbal Singh
    Phytomedicine Plus.2022; 2(3): 100288.     CrossRef
  • A panoptic review of techniques for finfish disease diagnosis: The status quo and future perspectives
    Tina Kollannoor Johny, Thangaraj Raja Swaminathan, Neeraj Sood, Pravata Kumar Pradhan, Kuldeep Kumar Lal
    Journal of Microbiological Methods.2022; 196: 106477.     CrossRef
  • Enhanced effect of autologous EVs delivering paclitaxel in pancreatic cancer
    Hasan Al Faruque, Eun-Sook Choi, Jung-Hee Kim, Eunjoo Kim
    Journal of Controlled Release.2022; 347: 330.     CrossRef
  • Standardization of Manual Method of Immunohistochemical Staining for Breast Cancer Biomarkers at Tertiary Cancer Care Center: An Audit
    Manjit K Rana, Amrit Pal S Rana, Aklank Jain, Akhilesh Pathak, Utkarshni Khera, Uttam Sharma, Akriti Jindal, Karuna Singh
    Cureus.2022;[Epub]     CrossRef
  • Trans-channel fluorescence learning improves high-content screening for Alzheimer’s disease therapeutics
    Daniel R. Wong, Jay Conrad, Noah R. Johnson, Jacob Ayers, Annelies Laeremans, Joanne C. Lee, Jisoo Lee, Stanley B. Prusiner, Sourav Bandyopadhyay, Atul J. Butte, Nick A. Paras, Michael J. Keiser
    Nature Machine Intelligence.2022; 4(6): 583.     CrossRef
  • Histopathological, Immunohistochemical and Biochemical Studies of Murine Hepatosplenic Tissues Affected by Chronic Toxoplasmosis
    Samah Hassan Yahia, Samia Elsayed Etewa, Nesreen Saeed Saleh, Samira Metwally Mohammad, Nora Ibrahim Aboulfotouh, Ahmad Mansour Kandil, Mohamed Hassan Sarhan, José F. Silveira
    Journal of Parasitology Research.2022; 2022: 1.     CrossRef
  • Development of a Single Molecule Counting Assay to Differentiate Chromophobe Renal Cancer and Oncocytoma in Clinics
    Khaled Bin Satter, Zach Ramsey, Paul M. H. Tran, Diane Hopkins, Gregory Bearden, Katherine P. Richardson, Martha K. Terris, Natasha M. Savage, Sravan K. Kavuri, Sharad Purohit
    Cancers.2022; 14(13): 3242.     CrossRef
  • LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions
    Peng Zhao, Yuanzhong Xu, Lu-Lin Jiang, Xuejun Fan, Zhiqiang Ku, Leike Li, Xiaoye Liu, Mi Deng, Hisashi Arase, Jay-Jiguang Zhu, Timothy Y. Huang, Yingjun Zhao, Chengcheng Zhang, Huaxi Xu, Qingchun Tong, Ningyan Zhang, Zhiqiang An
    Molecular Neurodegeneration.2022;[Epub]     CrossRef
  • Multiplex Immunofluorescence and the Digital Image Analysis Workflow for Evaluation of the Tumor Immune Environment in Translational Research
    Frank Rojas, Sharia Hernandez, Rossana Lazcano, Caddie Laberiano-Fernandez, Edwin Roger Parra
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Establishing a multiplex imaging panel to study T cell development in the thymus in mouse
    Amr H. Allam, Sarah M. Russell
    STAR Protocols.2022; 3(3): 101472.     CrossRef
  • Limited Accuracy of Pan-Trk Immunohistochemistry Screening for NTRK Rearrangements in Follicular-Derived Thyroid Carcinoma
    Elisabetta Macerola, Agnese Proietti, Anello Marcello Poma, Paola Vignali, Rebecca Sparavelli, Alessandro Ginori, Alessio Basolo, Rossella Elisei, Ferruccio Santini, Fulvio Basolo
    International Journal of Molecular Sciences.2022; 23(13): 7470.     CrossRef
  • Protective effect of green synthesized Selenium Nanoparticles against Doxorubicin induced multiple adverse effects in Swiss albino mice
    Mohammad Afsar Khan, Deepti Singh, Amin Arif, Kushneet Kaur Sodhi, Dileep Kumar Singh, Sk Najrul Islam, Absar Ahmad, Kafil Akhtar, Hifzur R. Siddique
    Life Sciences.2022; 305: 120792.     CrossRef
  • Runt-Related Transcription Factor 2 (Runx2) Measurement in Phytoestrogen-Induced Bone: A Comparison of Western Blot and Immunohistochemistry Methods
    Burhan Ma’arif, Fariza Amanatul Sholihah, Anisah Mahardiani, Begum Fauziyah, Denis Mery Mirza, Mangestuti Agil
    Biomedical and Pharmacology Journal.2022; 15(2): 1039.     CrossRef
  • Next-Generation Pathology Using Multiplexed Immunohistochemistry: Mapping Tissue Architecture at Single-Cell Level
    Francesca Maria Bosisio, Yannick Van Herck, Julie Messiaen, Maddalena Maria Bolognesi, Lukas Marcelis, Matthias Van Haele, Giorgio Cattoretti, Asier Antoranz, Frederik De Smet
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • The Role of Pathology-Based Methods in Qualitative and Quantitative Approaches to Cancer Immunotherapy
    Olga Kuczkiewicz-Siemion, Kamil Sokół, Beata Puton, Aneta Borkowska, Anna Szumera-Ciećkiewicz
    Cancers.2022; 14(15): 3833.     CrossRef
  • Epidermal Stem Cell in Wound Healing of Gliricidia sepium Leaves from Indonesia and the Philippines in Rats (Rattus norvegicus)
    Aulanni’am Aulanni’am, Ricadonna Raissa, Wibi Riawan, Dyah Kinasih Wuragil, Fajar Shodiq Permata, Ma Asuncion Guiang Beltran
    Open Access Macedonian Journal of Medical Sciences.2022; 10(A): 1143.     CrossRef
  • Immunohistochemical analysis of intestinal biopsies in individuals with celiac disease
    Adel Alhabbal, Imad Abou Khamis
    JGH Open.2022; 6(10): 692.     CrossRef
  • Morphofunctional State and Circadian Rhythms of the Liver of Female Rats under the Influence of Chronic Alcohol Intoxication and Constant Lighting
    David A. Areshidze, Maria A. Kozlova
    International Journal of Molecular Sciences.2022; 23(18): 10744.     CrossRef
  • Cardioprotective Effect of Taxifolin against Isoproterenol-Induced Cardiac Injury through Decreasing Oxidative Stress, Inflammation, and Cell Death, and Activating Nrf2/HO-1 in Mice
    Heba M. Obeidat, Osama Y. Althunibat, Manal A. Alfwuaires, Saleem H. Aladaileh, Abdulmohsen I. Algefare, Afaf F. Almuqati, Fawaz Alasmari, Hammad Khalifeh Aldal’in, Abdulkareem A. Alanezi, Bader Alsuwayt, Mohammad H. Abukhalil
    Biomolecules.2022; 12(11): 1546.     CrossRef
  • RhoA and vigilin are candidates for immunohistochemical markers for epithelioid malignant mesothelioma
    Takuya Hiratsuka, Takushi Yamamoto, Akihiko Yoshizawa, Shinya Toyokuni, Tatsuaki Tsuruyama
    Scientific Reports.2022;[Epub]     CrossRef
  • Assessment of survivin and p27 expression as potential prognostic markers in urothelial cell carcinoma of urinary bladder in Egyptian patients
    Noha Said Helal, Zeinab Omran, Mona Moussa
    African Journal of Urology.2022;[Epub]     CrossRef
  • Thymoquinone-rich black cumin oil attenuates ibotenic acid-induced excitotoxicity through glutamate receptors in Wistar rats
    Sibi P Ittiyavirah, Kannan Ramalingam, Arathy Sathyan, R.S. Rajasree, Mohamed Saheer Kuruniyan, Syed Altafuddin Quadri, Muhammed Elayadeth-Meethal, Punnoth Poonkuzhi Naseef
    Saudi Pharmaceutical Journal.2022; 30(12): 1781.     CrossRef
  • High sensitivity label-free detection of HER2 using an Al–GaN/GaN high electron mobility transistor-based biosensor
    Shivanshu Mishra, Pharyanshu Kachhawa, Amber Kumar Jain, Rajiv Ranjan Thakur, Nidhi Chaturvedi
    Lab on a Chip.2022; 22(21): 4129.     CrossRef
  • The effect of 1.3 bis(p-Hydroxyphenyl)urea compound on IL-6, IL-1β, TNF-α and COX-2 protein expression on λ-Carrageenan-induced rats
    Denny Satria, Syukur Berkat Waruwu, Yuandani Yuandani, Hari Purnomo, Urip Harahap
    Pharmacia.2022; 69(4): 927.     CrossRef
  • The unilateral involution in the thymus of a 96-year-old male leads to the preservation of structural integrity in one thymic lobe, as assessed by the expression of medullar and cortical antigens and the presence of CD3+ cells
    Pranuthi Kanneganti, Joseph Lyle, Julia H. Smith, Heather McGuire, Richaela Denlinger, Malgorzata Simm
    Heliyon.2022; 8(11): e11734.     CrossRef
  • Virtual tissue staining in pathology using machine learning
    Nir Pillar, Aydogan Ozcan
    Expert Review of Molecular Diagnostics.2022; 22(11): 987.     CrossRef
  • The Unilateral Involution in the Thymus of a 96-Year-Old Male Leads to the Preservation of Structural Integrity in One Thymic Lobe, as Assessed by the Expression of Medullar and Cortical Antigens and the Presence of CD3+ Cells
    Pranuthi Kanneganti, Julia H. Smith, Heather McGuire, Richaela Denlinger, Joseph Lyle, Malgorzata Simm
    SSRN Electronic Journal .2022;[Epub]     CrossRef
  • Upregulation of TIGIT and PD-1 in Colorectal Cancer with Mismatch-repair Deficiency
    Xuebing Zhou, Xiaoling Ding, Hai Li, Chun Yang, Zhanbing Ma, Guangxian Xu, Shaoqi Yang, Dong Zhang, Xiaoliang Xie, Lei Xin, Xiaoli Luo
    Immunological Investigations.2021; 50(4): 338.     CrossRef
  • The myokine irisin: localization and effects in swine late medium and large antral ovarian follicle
    G. Basini, S. Bussolati, M. Iannarelli, L. Ragionieri, S. Grolli, R. Ramoni, A. Dodi, F. Gazza, F. Grasselli
    Domestic Animal Endocrinology.2021; 74: 106576.     CrossRef
  • Heterochronous Metastases of Lung Adenocarcinoma to Pancreas and Liver: A Case Report from Pathological Perspectives
    Bo Zhang, Qida Hu, Jiajie Yu, Junsen Wang, Hanjin Yang, Jiongbo Lou, Guoying Cai, Haifeng Huang, Mengqiu Xu, Zhaoying Xiao, Yun Zhang
    OncoTargets and Therapy.2021; Volume 14: 4269.     CrossRef
  • Human Adipose Derived Stem Cells Enhance Healing in a Rat Model of Esophageal Injury with Stent
    Dana McCloskey, Kimberly Linden, Andrew Lin, Ping Zhang, Jennifer Schweinsburg, Atlee Melillo, Huan Wang, Julieta Barroeta, Spencer Brown, Jeffrey Carpenter, Francis Spitz, David Shersher
    Journal of Surgical Research.2021; 267: 458.     CrossRef
  • Quantification of the Immune Content in Neuroblastoma: Deep Learning and Topological Data Analysis in Digital Pathology
    Nicole Bussola, Bruno Papa, Ombretta Melaiu, Aurora Castellano, Doriana Fruci, Giuseppe Jurman
    International Journal of Molecular Sciences.2021; 22(16): 8804.     CrossRef
  • Deep learning for the classification of medical kidney disease: a pilot study for electron microscopy
    Sean Hacking, Vanesa Bijol
    Ultrastructural Pathology.2021; 45(2): 118.     CrossRef
  • Multiplexed Plasmonic Nano-Labeling for Bioimaging of Cytological Stained Samples
    Paule Marcoux-Valiquette, Cécile Darviot, Lu Wang, Andrée-Anne Grosset, Morteza Hasanzadeh Kafshgari, Mirela Birela, Sergiy Patskovsky, Dominique Trudel, Michel Meunier
    Cancers.2021; 13(14): 3509.     CrossRef
  • The Expression of NTAL and Its Protein Interactors Is Associated With Clinical Outcomes in Acute Myeloid Leukemia
    Carolina Hassibe Thomé, Germano Aguiar Ferreira, Diego Antonio Pereira-Martins, Guilherme Augusto dos Santos, Douglas R. Almeida-Silveira, Isabel Weinhäuser, Gustavo Antônio de Souza, Roos Houtsma, Jan Jacob Schuringa, Eduardo M. Rego, Vitor M. Faça
    Molecular & Cellular Proteomics.2021; 20: 100091.     CrossRef
  • Quercetin attenuates cisplatin-induced ovarian toxicity in rats: Emphasis on anti-oxidant, anti-inflammatory and anti-apoptotic activities
    Mardi M. Algandaby
    Arabian Journal of Chemistry.2021; 14(7): 103191.     CrossRef
  • A biochemical mechanism for time-encoding memory formation within individual synapses of Purkinje cells
    Ayush Mandwal, Javier G. Orlandi, Christoph Simon, Jörn Davidsen, Laurens W. J. Bosman
    PLOS ONE.2021; 16(5): e0251172.     CrossRef
  • Alleviation of remote lung injury following liver ischemia/reperfusion: Possible protective role of vildagliptin
    Iman O. Sherif, Nora H. Al-Shaalan
    International Immunopharmacology.2021; 91: 107305.     CrossRef
  • Raman spectroscopy and group and basis-restricted non negative matrix factorisation identifies radiation induced metabolic changes in human cancer cells
    Kirsty Milligan, Xinchen Deng, Phillip Shreeves, Ramie Ali-Adeeb, Quinn Matthews, Alexandre Brolo, Julian J. Lum, Jeffrey L. Andrews, Andrew Jirasek
    Scientific Reports.2021;[Epub]     CrossRef
  • In Vitro Liver Toxicity Testing of Chemicals: A Pragmatic Approach
    Andrés Tabernilla, Bruna dos Santos Rodrigues, Alanah Pieters, Anne Caufriez, Kaat Leroy, Raf Van Campenhout, Axelle Cooreman, Ana Rita Gomes, Emma Arnesdotter, Eva Gijbels, Mathieu Vinken
    International Journal of Molecular Sciences.2021; 22(9): 5038.     CrossRef
  • The steadfast Au@Pt soldier: Peroxide-tolerant nanozyme for signal enhancement in lateral flow immunoassay of peroxidase-containing samples
    Vasily G. Panferov, Irina V. Safenkova, Anatoly V. Zherdev, Boris B. Dzantiev
    Talanta.2021; 225: 121961.     CrossRef
  • Use of CRISPR/Cas9-mediated disruption of CNS cell type genes to profile transduction of AAV by neonatal intracerebroventricular delivery in mice
    Tess Torregrosa, Sydney Lehman, Sam Hana, Galina Marsh, Shanqin Xu, Kathryn Koszka, Nicole Mastrangelo, Alexander McCampbell, Christopher E. Henderson, Shih-Ching Lo
    Gene Therapy.2021; 28(7-8): 456.     CrossRef
  • Hepatoprotective effect of arjunolic acid against cisplatin‐induced hepatotoxicity: Targeting oxidative stress, inflammation, and apoptosis
    Iman O. Sherif
    Journal of Biochemical and Molecular Toxicology.2021;[Epub]     CrossRef
  • Topical ozonated virgin coconut oil improves wound healing and increases HSP90α, VEGF-A, EGF, bFGF and CD34 in diabetic ulcer mouse model of wound healing
    Renni Yuniati, Prasetyowati Subchan, Wibi Riawan, Matthew Brian Khrisna, Maryam Restiwijaya, Niken Safitri Dyan Kusumaningrum, Muhammad Nur
    F1000Research.2021; 9: 580.     CrossRef
  • IHC_Tool: An open-source Fiji procedure for quantitative evaluation of cross sections of testicular explants
    Ludovic Dumont, Nicolas Levacher, Damien Schapman, Aurélie Rives-Feraille, Laura Moutard, Marion Delessard, Justine Saulnier, Christine Rondanino, Nathalie Rives
    Reproductive Biology.2021; 21(2): 100507.     CrossRef
  • Challenges with Methods for Detecting and Studying the Transcription Factor Nuclear Factor Kappa B (NF-κB) in the Central Nervous System
    Marina Mostafizar, Claudia Cortes-Pérez, Wanda Snow, Jelena Djordjevic, Aida Adlimoghaddam, Benedict C. Albensi
    Cells.2021; 10(6): 1335.     CrossRef
  • High‐Dimensional Image Analysis using Histocytometry
    Luis Munoz‐Erazo, Alfonso J. Schmidt, Kylie M. Price
    Current Protocols.2021;[Epub]     CrossRef
  • Serum matrix metalloproteinase-13 as a diagnostic biomarker for cutaneous squamous cell carcinoma
    Hui Wang, Hong Li, Qingtao Yan, Sumei Gao, Jianfang Gao, Zhenhua Wang, Yi Sun
    BMC Cancer.2021;[Epub]     CrossRef
  • Machine Learning Approaches to Classify Primary and Metastatic Cancers Using Tissue of Origin-Based DNA Methylation Profiles
    Vijayachitra Modhukur, Shakshi Sharma, Mainak Mondal, Ankita Lawarde, Keiu Kask, Rajesh Sharma, Andres Salumets
    Cancers.2021; 13(15): 3768.     CrossRef
  • Effects of Automation on Sustainability of Immunohistochemistry Laboratory
    Marija Đorđević, Maja Životić, Sanja Radojević Škodrić, Jelena Nešović Ostojić, Jasmina Marković Lipkovski, Jelena Filipović, Sanja Ćirović, Sanjin Kovačević, Duško Dunđerović
    Healthcare.2021; 9(7): 866.     CrossRef
  • Kallikrein-11, in Association with Coiled-Coil Domain Containing 25, as a Potential Prognostic Marker for Cholangiocarcinoma with Lymph Node Metastasis
    Saeranee Siriphak, Ravinnipa Chanakankun, Tanakorn Proungvitaya, Sittiruk Roytrakul, Doungdean Tummanatsakun, Wunchana Seubwai, Molin Wongwattanakul, Siriporn Proungvitaya
    Molecules.2021; 26(11): 3105.     CrossRef
  • Pitfalls and Caveats in Applying Chromogenic Immunostaining to Histopathological Diagnosis
    Yutaka Tsutsumi
    Cells.2021; 10(6): 1501.     CrossRef
  • A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei
    Jude M. Phillip, Kyu-Sang Han, Wei-Chiang Chen, Denis Wirtz, Pei-Hsun Wu
    Nature Protocols.2021; 16(2): 754.     CrossRef
  • Clinical implications of lung neuroendocrine neoplasm classification
    Jasna Metovic, Marco Barella, Sergio Harari, Linda Pattini, Adriana Albini, Angelica Sonzogni, Giulia Veronesi, Mauro Papotti, Giuseppe Pelosi
    Expert Review of Anticancer Therapy.2021; 21(4): 377.     CrossRef
  • Comparative protective effects of N-acetylcysteine and melatonin against obesity-induced testicular dysfunction in rats
    Sama S. Khalil, Joseph Amin Aziz, Khadiga Ahmed Ismail, Nanees F. El-Malkey
    Canadian Journal of Physiology and Pharmacology.2021; 99(7): 708.     CrossRef
  • Development of novel quality control material based on CRISPR/Cas9 editing and xenografts for MLH1 protein deficiency testing
    Rui Li, Runling Zhang, Ping Tan, Meng Wang, Yuqing Chen, Jiawei Zhang, Dongsheng Han, Yanxi Han, Jinming Li, Rui Zhang
    Journal of Clinical Laboratory Analysis.2021;[Epub]     CrossRef
  • Optimization of Mouse-on-Mouse Immunohistochemistry by Utilizing Fluorescent-dye Conjugated Secondary Anti-Mouse Antibody
    Shiva Moein, Rezvan Adibi, Alireza Amouheidari, Yousof Gheisari
    Applied Immunohistochemistry & Molecular Morphology.2021; 29(6): 473.     CrossRef
  • Multiplex Immunofluorescence and Multispectral Imaging: Forming the Basis of a Clinical Test Platform for Immuno-Oncology
    Clifford C. Hoyt
    Frontiers in Molecular Biosciences.2021;[Epub]     CrossRef
  • The changing role of the pathologist in the era of targeted therapy in personalized medicine
    Giuseppe D’Abbronzo, Renato Franco
    Expert Review of Precision Medicine and Drug Development.2021; 6(5): 295.     CrossRef
  • The advanced development of Cx43 and GAP-43 mediated intercellular networking in IDH1 wildtype diffuse and anaplastic gliomas with lower mitotic rate
    Aleksandrs Krigers, Patrizia Moser, Helga Fritsch, Matthias Demetz, Konstantin Brawanski, Claudius Thomé, Christian F. Freyschlag
    Journal of Cancer Research and Clinical Oncology.2021; 147(10): 3003.     CrossRef
  • Tunable Organelle Imaging by Rational Design of Carbon Dots and Utilization of Uptake Pathways
    Shuang E, Chuang He, Jian-Hua Wang, Quanxing Mao, Xuwei Chen
    ACS Nano.2021; 15(9): 14465.     CrossRef
  • Adaptive NK Cell Therapy Modulated by Anti-PD-1 Antibody in Gastric Cancer Model
    Shahrokh Abdolahi, Zeinab Ghazvinian, Samad Muhammadnejad, Mohammad Ahmadvand, Hamid Asadzadeh Aghdaei, Somayeh Ebrahimi-Barough, Jafar Ai, Mohammad Reza Zali, Javad Verdi, Kaveh Baghaei
    Frontiers in Pharmacology.2021;[Epub]     CrossRef
  • Topical ozonated virgin coconut oil improves wound healing and increases HSP90α, VEGF-A, EGF, bFGF, and CD34 in diabetic ulcer mouse model of wound healing
    Renni Yuniati, Prasetyowati Subchan, Wibi Riawan, Matthew Brian Khrisna, Maryam Restiwijaya, Niken Safitri Dyan Kusumaningrum, Muhammad Nur
    F1000Research.2021; 9: 580.     CrossRef
  • Automated Quantitative Image Evaluation of Antigen Retrieval Methods for 17 Antibodies in Placentation and Implantation Diagnostic and Research
    Julia Fuchs, Olivia Nonn, Christine Daxboeck, Silvia Groiss, Gerit Moser, Martin Gauster, Ingrid Lang-Olip, Dagmar Brislinger
    Microscopy and Microanalysis.2021; 27(6): 1506.     CrossRef
  • Prognostic Value of Serum Thyroglobulin and Anti-Thyroglobulin Antibody in Thyroid Carcinoma Patients following Thyroidectomy
    Hashem O. Zahra, Gamal A. Omran, Ahmed G. Gewely, Ahmed Fathy Eldehn, Walied Abdo, Ehab Kotb Elmahallawy, Tarek M. Okda
    Diagnostics.2021; 11(11): 2080.     CrossRef
  • Hybridization chain reaction enables a unified approach to multiplexed, quantitative, high-resolution immunohistochemistry and in situ hybridization
    Maayan Schwarzkopf, Mike C. Liu, Samuel J. Schulte, Rachel Ives, Naeem Husain, Harry M. T. Choi, Niles A. Pierce
    Development.2021;[Epub]     CrossRef
  • Immunohistochemical Analysis of the Expression of the Glycodelin Cytokine in Endometrial Tissue and the Endometrial Polyp, Before and After Hysteroscopy, in Infertile Female Patients
    Aleksandar Dević, Ana Dević, Marija Šorak, Goran Zajić, Slobodanka Mitrović
    Serbian Journal of Experimental and Clinical Research.2021;[Epub]     CrossRef
  • Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology
    Timothy M Errington, Alexandria Denis, Anne B Allison, Renee Araiza, Pedro Aza-Blanc, Lynette R Bower, Jessica Campos, Heidi Chu, Sarah Denson, Cristine Donham, Kaitlyn Harr, Babette Haven, Elizabeth Iorns, Jennie Kwok, Elysia McDonald, Steven Pelech, Nic
    eLife.2021;[Epub]     CrossRef
  • Reconciling the distinct roles of angiogenic/anti-angiogenic factors in the placenta and maternal circulation of normal and pathological pregnancies
    Anandita Umapathy, Lawrence W. Chamley, Joanna L. James
    Angiogenesis.2020; 23(2): 105.     CrossRef
  • A comparison of methodologies for the staining and quantification of intracellular components of arbuscular mycorrhizal fungi in the root cortex of two varieties of winter wheat
    Thomas I. Wilkes, Douglas J. Warner, Veronica Edmonds-Brown, Keith G. Davies, Ian Denholm
    Access Microbiology .2020;[Epub]     CrossRef
  • Parallel Reaction Monitoring-Mass Spectrometry (PRM-MS)-Based Targeted Proteomic Surrogates for Intrinsic Subtypes in Breast Cancer: Comparative Analysis with Immunohistochemical Phenotypes
    Joonho Park, Hyeon Jeong Oh, Dohyun Han, Joseph I. Wang, In Ae Park, Han Suk Ryu, Youngsoo Kim
    Journal of Proteome Research.2020; 19(7): 2643.     CrossRef
  • Prognostic value of mitotic checkpoint protein BUB3, cyclin B1, and pituitary tumor-transforming 1 expression in prostate cancer
    Elin Ersvær, Wanja Kildal, Ljiljana Vlatkovic, Karolina Cyll, Manohar Pradhan, Andreas Kleppe, Tarjei S. Hveem, Hanne A. Askautrud, Marco Novelli, Håkon Wæhre, Knut Liestøl, Håvard E. Danielsen
    Modern Pathology.2020; 33(5): 905.     CrossRef
  • Evaluating the Polarization of Tumor-Associated Macrophages Into M1 and M2 Phenotypes in Human Cancer Tissue: Technicalities and Challenges in Routine Clinical Practice
    Sharmilla Devi Jayasingam, Marimuthu Citartan, Thean Hock Thang, Anani Aila Mat Zin, Kai Cheen Ang, Ewe Seng Ch'ng
    Frontiers in Oncology.2020;[Epub]     CrossRef
  • Exploring the challenges for a new classification of adenomyosis
    Marwan Habiba, Stephan Gordts, Marc Bazot, Ivo Brosens, Giuseppe Benagiano
    Reproductive BioMedicine Online.2020; 40(4): 569.     CrossRef
  • The importance of FDG-PET/CT parameters for the assessment of the immune status in advanced HNSCC
    Toshimitsu Ohashi, Kousuke Terasawa, Mitsuhiro Aoki, Takashi Akazawa, Hirofumi Shibata, Bunya Kuze, Takahiko Asano, Hiroki Kato, Tatsuhiko Miyazaki, Masayuki Matsuo, Norimitsu Inoue, Yatsuji Ito
    Auris Nasus Larynx.2020; 47(4): 658.     CrossRef
  • Local secretion of stress hormones increases in alopecia areata lesions after treatment with UVA‐1 phototherapy
    Adrian Cuellar‐Barboza, Jesus Alberto Cardenas‐de la Garza, Luis Gerardo Cruz‐Gómez, Oralia Barboza‐Quintana, Juan Pablo Flores‐Gutiérrez, Minerva Gómez‐Flores, Oliverio Welsh, Jorge Ocampo‐Candiani, Maira E. Herz‐Ruelas
    Experimental Dermatology.2020; 29(3): 259.     CrossRef
  • Asialoglycoprotein receptor expression in placenta of women with Hepatitis B Virus e Antigen (HBeAg) positive and negative
    Agus Priyo Wibowo, Rina Masadah, Berti J. Nelwana, Djumadi Achmad, Gunawan Arsyadi, Maisuri T. Chalid, Andi Alfian Zainuddin
    Enfermería Clínica.2020; 30: 255.     CrossRef
  • Comparison of Volume Retention and Biocompatibility of Acellular Dermal Matrix/Hyaluronic Acid Filler to Autologous Fat Grafts in a Mouse Model
    Ji Hun Kim, Sun Eung Kim, Yu Jin Kim, Yang Woo Kim, Young Woo Cheon
    Aesthetic Plastic Surgery.2020; 44(3): 986.     CrossRef
  • An improved animal model for herpesvirus encephalitis in humans
    Julia Sehl, Julia E. Hölper, Barbara G. Klupp, Christina Baumbach, Jens P. Teifke, Thomas C. Mettenleiter, Lynn W. Enquist
    PLOS Pathogens.2020; 16(3): e1008445.     CrossRef
  • Fluorescent Carbon Dots for Selective Labeling of Subcellular Organelles
    Binesh Unnikrishnan, Ren-Siang Wu, Shih-Chun Wei, Chih-Ching Huang, Huan-Tsung Chang
    ACS Omega.2020; 5(20): 11248.     CrossRef
  • Effects of coal-fired PM2.5 on the expression levels of atherosclerosis-related proteins and the phosphorylation level of MAPK in ApoE−/− mice
    Siqi Wang, Feifei Wang, Lixin Yang, Qin Li, Yao Huang, Zhiyuan Cheng, Hongqian Chu, Yiming Song, Lanqin Shang, Weidong Hao, Xuetao Wei
    BMC Pharmacology and Toxicology.2020;[Epub]     CrossRef
  • Hyperspectral and multispectral imaging in digital and computational pathology: a systematic review [Invited]
    Samuel Ortega, Martin Halicek, Himar Fabelo, Gustavo M. Callico, Baowei Fei
    Biomedical Optics Express.2020; 11(6): 3195.     CrossRef
  • Topical ozonated virgin coconut oil improves wound healing and increases HSP90α, VEGF-A, EGF, bFGF and CD34 in diabetic ulcer mouse model of wound healing
    Renni Yuniati, Prasetyowati Subchan, Wibi Riawan, Matthew Brian Khrisna, Maryam Restiwijaya, Niken Safitri Dyan Kusumaningrum, Muhammad Nur
    F1000Research.2020; 9: 580.     CrossRef
  • Immune characterization of metastatic colorectal cancer patients post reovirus administration
    Ruwan Parakrama, Elisha Fogel, Carol Chandy, Titto Augustine, Matt Coffey, Lydia Tesfa, Sanjay Goel, Radhashree Maitra
    BMC Cancer.2020;[Epub]     CrossRef
  • 2-Methoxyestradiol ameliorates metabolic syndrome-induced hypertension and catechol-O-methyltransferase inhibited expression and activity in rats
    Ahmad S. Azhar, Zaher F. Zaher, Osama M. Ashour, Ashraf B. Abdel-Naim
    European Journal of Pharmacology.2020; 882: 173278.     CrossRef
  • In vitro and in vivo anti-proliferative activity and ultrastructure investigations of a copper(II) complex toward human lung cancer cell NCI-H460
    Leide Laura Figueiredo Maciel, William Rodrigues de Freitas, Erika Soares Bull, Christiane Fernandes, Adolfo Horn, João Carlos de Aquino Almeida, Milton Masahiko Kanashiro
    Journal of Inorganic Biochemistry.2020; 210: 111166.     CrossRef
  • Immunocytochemistry practices in European cytopathology laboratories—Review of European Federation of Cytology Societies (EFCS) online survey results with best practice recommendations
    Irena Srebotnik Kirbiš, Rúben Rodrigues Roque, Massimo Bongiovanni, Margareta Strojan Fležar, Béatrix Cochand‐Priollet
    Cancer Cytopathology.2020; 128(10): 757.     CrossRef
  • CdSe quantum dots evaluation in primary cellular models or tissues derived from patients
    Carlota Tosat-Bitrián, Valle Palomo
    Nanomedicine: Nanotechnology, Biology and Medicine.2020; 30: 102299.     CrossRef
  • Carbonic anhydrase IX (CA9) expression in multiple renal epithelial tumour subtypes
    Nicholas Baniak, Trevor A Flood, Mark Buchanan, Paola Dal Cin, Michelle S Hirsch
    Histopathology.2020; 77(4): 659.     CrossRef
  • PCSK2 expression in neuroendocrine tumors points to a midgut, pulmonary, or pheochromocytoma–paraganglioma origin
    Satu Maria Remes, Helena Leijon, Tiina Vesterinen, Johanna Louhimo, Ville Pulkkinen, Sini Ezer, Juha Kere, Caj Haglund, Johanna Arola
    APMIS.2020; 128(11): 563.     CrossRef
  • An immunochemistry-based screen for chemical inhibitors of DNA-protein interactions and its application to human CGGBP1
    Manthan Patel, Divyesh Patel, Subhamoy Datta, Umashankar Singh
    BMC Cancer.2020;[Epub]     CrossRef
  • Correlation of VEGF and MMP-2 levels in oral lichen planus: An in vivo immunohistochemical study
    Hala H. Hazzaa, Marwa A.M. El Shiekh, Nora Abdelgawad, Ossama M. Gouda, Naglaa M. Kamal
    Journal of Oral Biology and Craniofacial Research.2020; 10(4): 747.     CrossRef
  • Ginkgo biloba Extract Attenuates Methotrexate-Induced Testicular Injury in Rats: Cross-talk Between Oxidative Stress, Inflammation, Apoptosis, and miRNA-29a Expression
    Iman O. Sherif, Laila A. Al-Mutabagani, Osama M. Sarhan
    Integrative Cancer Therapies.2020; 19: 153473542096981.     CrossRef
  • Pathological features of nasopharyngeal carcinoma: A single-center study in Vietnam
    Nguyen Cuong Pham, Thanh Xuan Nguyen, Nguyen Tuong Pham, Thanh Chinh Phan, Hai Thanh Phan
    Annals of Cancer Research and Therapy.2020; 28(2): 125.     CrossRef
  • Immunofluorescence Staining of Paraffin Sections Step by Step
    Sami Zaqout, Lena-Luise Becker, Angela M. Kaindl
    Frontiers in Neuroanatomy.2020;[Epub]     CrossRef
  • Immunohistochemistry as an important tool for exploring the insights of various aspects of gastro-intestinal tract
    Ritesh Kumar Shukla, N Venkat Appa Rao
    The Applied Biology & Chemistry Journal.2020; : 72.     CrossRef
  • Development of a CD63 Aptamer for Efficient Cancer Immunochemistry and Immunoaffinity-Based Exosome Isolation
    Zhenguo Song, Jun Mao, Roberto Barrero, Peng Wang, Fengqiu Zhang, Tao Wang
    Molecules.2020; 25(23): 5585.     CrossRef
  • Influence of chitosan oligosaccharide on the gelling and wound healing properties of injectable hydrogels based on carboxymethyl chitosan/alginate polyelectrolyte complexes
    Xiaojie Lv, Yunen Liu, Subin Song, Changci Tong, Xiuyun Shi, Yan Zhao, Jinsong Zhang, Mingxiao Hou
    Carbohydrate Polymers.2019; 205: 312.     CrossRef
  • The interrelationship between gasotransmitters and lead-induced renal toxicity in rats
    Ahmed O. Abdel-Zaher, Rasha B. Abd-ellatief, Noha A. Aboulhagag, Hanan S.M. Farghaly, Fahmy M.M. AL-Wasei
    Toxicology Letters.2019; 310: 39.     CrossRef
  • Inflammation‐dependent overexpression of c‐Myc enhances CRL4DCAF4 E3 ligase activity and promotes ubiquitination of ST7 in colitis‐associated cancer
    Hong Liu, Wenzhu Lu, Hongbo He, Jin Wu, Caiguo Zhang, Hanlin Gong, Chunmei Yang
    The Journal of Pathology.2019; 248(4): 464.     CrossRef
  • Candesartan in a rat model of testicular toxicity: New insight on its protective mechanism
    Iman O Sherif, Osama M Sarhan
    Experimental Biology and Medicine.2019; 244(7): 593.     CrossRef
  • A survival guide to HER2 testing in gastric/gastroesophageal junction carcinoma
    Duminda Subasinghe, Nathan Acott, Marian Priyanthi Kumarasinghe
    Gastrointestinal Endoscopy.2019; 90(1): 44.     CrossRef
  • Tumor-Associated Protein Profiles in Kaposi Sarcoma and Mimicking Vascular Tumors, and Their Pathological Implications
    Kyoung Bun Lee, Kyu Sang Lee, Hye Seung Lee
    International Journal of Molecular Sciences.2019; 20(13): 3142.     CrossRef
  • New advance in breast cancer pathology and imaging
    Nicoletta Urbano, Manuel Scimeca, Rita Bonfiglio, Elena Bonanno, Orazio Schillaci
    Future Oncology.2019; 15(23): 2707.     CrossRef
  • Pathology Services in Nigeria: Cross-Sectional Survey Results From Three Cancer Consortia
    Peter Ntiamoah, Ngozi R. Monu, Fatimah B. Abdulkareem, Kayode A. Adeniji, John O. Obafunwa, Akinwumi O. Komolafe, Clayton Yates, Ernest Kaninjing, John D. Carpten, Bodour Salhia, Folake T. Odedina, Marcia Edelweiss, T. Peter Kingham, Olusegun I. Alatise
    Journal of Global Oncology.2019; (5): 1.     CrossRef
  • Efficient Epidermal Growth Factor Receptor Targeting Oligonucleotide as a Potential Molecule for Targeted Cancer Therapy
    Tao Wang, Svetlana Philippovich, Jun Mao, Rakesh N. Veedu
    International Journal of Molecular Sciences.2019; 20(19): 4700.     CrossRef
  • The Role of MMP8 in Cancer: A Systematic Review
    Juurikka, Butler, Salo, Nyberg, Åström
    International Journal of Molecular Sciences.2019; 20(18): 4506.     CrossRef
  • Enhancing the Value of Histopathological Assessment of Allograft Biopsy Monitoring
    Michelle A. Wood-Trageser, Andrew J. Lesniak, Anthony J. Demetris
    Transplantation.2019; 103(7): 1306.     CrossRef
  • Anything You Can Do, I Can Do Better: Can Aptamers Replace Antibodies in Clinical Diagnostic Applications?
    Michelle Bauer, Mia Strom, David S Hammond, Sarah Shigdar
    Molecules.2019; 24(23): 4377.     CrossRef
  • A nuclear shift of GSK3β protein is an independent prognostic factor in prostate cancer
    Till Eichenauer, Mohammad Hussein, Claudia Hube-Magg, Martina Kluth, Franziska Büscheck, Doris Höflmayer, Maria Christina Tsourlakis, Stefan Steurer, Till S. Clauditz, Andreas M. Luebke, Eike Burandt, Waldemar Wilczak, Andrea Hinsch, David Dum, Burkhard B
    Oncotarget.2019; 10(18): 1729.     CrossRef
  • Update on Immunohistochemistry for the Diagnosis of Lung Cancer
    Kentaro Inamura
    Cancers.2018; 10(3): 72.     CrossRef
  • The path to VICTORy – a beginner's guide to success using commercial research antibodies
    Simon L. Goodman
    Journal of Cell Science.2018;[Epub]     CrossRef
  • Translational research: Empowering the role of pathologists and cytopathologists
    Heba W. Z. Khella, George M. Yousef
    Cancer Cytopathology.2018; 126(10): 831.     CrossRef
  • Periostin involved in the activated hepatic stellate cells-induced progression of residual hepatocellular carcinoma after sublethal heat treatment: its role and potential for therapeutic inhibition
    Rui Zhang, Xia-Hui Lin, Min Ma, Jie Chen, Jun Chen, Dong-Mei Gao, Jie-Feng Cui, Rong-Xin Chen
    Journal of Translational Medicine.2018;[Epub]     CrossRef
  • Analysis of PKC‑ζ protein levels in normal and malignant breast tissue subtypes
    Tracess Smalley, S. Islam, Christopher Apostolatos, Andr� Apostolatos, Mildred Acevedo‑Duncan
    Oncology Letters.2018;[Epub]     CrossRef
  • Aberrant expression of glycogen synthase kinase‑3β in human breast and head and neck cancer
    Andrey Ugolkov, Maria Matsangou, Timothy Taxter, Thomas O'Halloran, Vincent Cryns, Francis Giles, Andrew Mazar
    Oncology Letters.2018;[Epub]     CrossRef
  • The Pathological Diagnosis and Interpretation of Pathological Results: Emphasis on Immunohistochemical Staining
    Jae Ho Han
    The Korean Journal of Medicine.2017; 92(1): 36.     CrossRef
  • Activated hepatic stellate cells secrete periostin to induce stem cell-like phenotype of residual hepatocellular carcinoma cells after heat treatment
    Rui Zhang, Rong-Rong Yao, Jing-Huan Li, Gang Dong, Min Ma, Qiong-Dan Zheng, Dong-Mei Gao, Jie-Feng Cui, Zheng-Gang Ren, Rong-Xin Chen
    Scientific Reports.2017;[Epub]     CrossRef
  • ALK in Non-Small Cell Lung Cancer (NSCLC) Pathobiology, Epidemiology, Detection from Tumor Tissue and Algorithm Diagnosis in a Daily Practice
    Paul Hofman
    Cancers.2017; 9(12): 107.     CrossRef
  • Metas-Chip precisely identifies presence of micrometastasis in live biopsy samples by label free approach
    Mohammad Saeid Nikshoar, Mohammad Ali Khayamian, Saeid Ansaryan, Hassan Sanati, Milad Gharooni, Leila Farahmand, Farshad Rezakhanloo, Keivan Majidzadeh-A, Parisa Hoseinpour, Shahrzad Dadgari, Leila Kiani-M, Mohammad Saqafi, Masoumeh Gity, Mohammad Abdolah
    Nature Communications.2017;[Epub]     CrossRef
Original Article
Cancers with Higher Density of Tumor-Associated Macrophages Were Associated with Poor Survival Rates
Kyong Yeun Jung, Sun Wook Cho, Young A Kim, Daein Kim, Byung-Chul Oh, Do Joon Park, Young Joo Park
J Pathol Transl Med. 2015;49(4):318-324.   Published online June 17, 2015
DOI: https://doi.org/10.4132/jptm.2015.06.01
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AbstractAbstract PDF
Background
Macrophages are a component of a tumor’s microenvironment and have various roles in tumor progression and metastasis. This study evaluated the relationships between tumor-associated macrophage (TAM) density and clinical outcomes in 14 different types of human cancers. Methods: We investigated TAM density in human tissue microarray sections from 14 different types of human cancers (n = 266) and normal thyroid, lung, and breast tissues (n = 22). The five-year survival rates of each cancer were obtained from the 2011 Korea Central Cancer Registry. Results: Among 13 human cancers, excluding thyroid cancer, pancreas, lung, and gallbladder cancers had the highest density of CD163-positive macrophages (7.0±3.5%, 6.9±7.4%, and 6.9 ± 5.5%, respectively). The five-year relative survival rates of these cancers (pancreas, 8.7%; lung, 20.7%; gallbladder, 27.5%) were lower than those of other cancers. The histological subtypes in thyroid cancer exhibited significantly different CD163-positive macrophages densities (papillary, 1.8 ± 1.6% vs anaplastic, 22.9 ± 17.1%; p < .001), but no significant difference between histological subtypes was detected in lung and breast cancers. Moreover, there was no significant difference in CD163-positive macrophages densities among the TNM stages in lung, breast, and thyroid cancers. Conclusions: Cancers with higher TAM densities (pancreas, lung, anaplastic thyroid, and gallbladder) were associated with poor survival rate.

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  • Circulating immunophenotypes are potentially prognostic in follicular cell-derived thyroid cancer
    Anupam Kotwal, Michael P. Gustafson, Svetlana Bornschlegl, Allan B. Dietz, Danae Delivanis, Mabel Ryder
    Frontiers in Immunology.2024;[Epub]     CrossRef
  • Nano-enhanced immunotherapy: Targeting the immunosuppressive tumor microenvironment
    Yuzhi Jin, Yangyue Huang, Hui Ren, Huanhuan Huang, Chunyu Lai, Wenjun Wang, Zhou Tong, Hangyu Zhang, Wei Wu, Chuan Liu, Xuanwen Bao, Weijia Fang, Hongjun Li, Peng Zhao, Xiaomeng Dai
    Biomaterials.2024; 305: 122463.     CrossRef
  • Tumor microenvironment in thyroid cancer: Immune cells, patterns, and novel treatments
    Beatriz Febrero, Juan José Ruiz‐Manzanera, Inmaculada Ros‐Madrid, Antonio Miguel Hernández, Esteban Orenes‐Piñero, José Manuel Rodríguez
    Head & Neck.2024;[Epub]     CrossRef
  • Research progress of immunotherapy against anaplastic thyroid cancer
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    European Journal of Immunology.2024;[Epub]     CrossRef
  • Monocytes in leukapheresis products affect the outcome of CD19–targeted CAR T-cell therapy in patients with lymphoma
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    Blood Advances.2024; 8(8): 1968.     CrossRef
  • The ratio of adaptive to innate immune cells differs between genders and associates with improved prognosis and response to immunotherapy
    Johanne Ahrenfeldt, Ditte S. Christensen, Andreas B. Østergaard, Judit Kisistók, Mateo Sokač, Nicolai J. Birkbak, Albert Rübben
    PLOS ONE.2023; 18(2): e0281375.     CrossRef
  • Current Landscape of Immunotherapy for Advanced Sarcoma
    Víctor Albarrán, María Luisa Villamayor, Javier Pozas, Jesús Chamorro, Diana Isabel Rosero, María San Román, Patricia Guerrero, Patricia Pérez de Aguado, Juan Carlos Calvo, Coral García de Quevedo, Carlos González, María Ángeles Vaz
    Cancers.2023; 15(8): 2287.     CrossRef
  • Iron-mediated oxidative stress induces PD-L1 expression via activation of c-Myc in lung adenocarcinoma
    Anna Martina Battaglia, Alessandro Sacco, Ilenia Aversa, Gianluca Santamaria, Camillo Palmieri, Cirino Botta, Roberto De Stefano, Maurizio Bitetto, Lavinia Petriaggi, Emanuele Giorgio, Concetta Maria Faniello, Francesco Costanzo, Flavia Biamonte
    Frontiers in Cell and Developmental Biology.2023;[Epub]     CrossRef
  • Molecular mechanisms of immunotherapy resistance in triple-negative breast cancer
    Yiwen Zheng, Shujin Li, Hongchao Tang, Xuli Meng, Qinghui Zheng
    Frontiers in Immunology.2023;[Epub]     CrossRef
  • Modeling the tumor microenvironment of anaplastic thyroid cancer: an orthotopic tumor model in C57BL/6 mice
    Zhen Xu, Hyo Shik Shin, Yoo Hyung Kim, Seong Yun Ha, Jae-Kyung Won, Su-jin Kim, Young Joo Park, Sareh Parangi, Sun Wook Cho, Kyu Eun Lee
    Frontiers in Immunology.2023;[Epub]     CrossRef
  • A new approach to overcoming resistance to immunotherapy: nanotechnology
    Jiangbo Shao, Ying Jin, Chunxiang Jin
    Frontiers in Oncology.2023;[Epub]     CrossRef
  • Integrative single-cell transcriptome analysis reveals immune suppressive landscape in the anaplastic thyroid cancer
    Chao Feng, Yujia Tao, Chao Yu, Lirui Wang, Xiao Liu, Yuan Cao
    Cancer Gene Therapy.2023; 30(12): 1598.     CrossRef
  • Tumor-associated macrophages as a potential therapeutic target in thyroid cancers
    Liya Zhu, Xiu Juan Li, Prakash Gangadaran, Xiuli Jing, Byeong-Cheol Ahn
    Cancer Immunology, Immunotherapy.2023; 72(12): 3895.     CrossRef
  • Influence of Macrophages on Vascular Invasion of Inflammatory Breast Cancer Emboli Measured Using an In Vitro Microfluidic Multi-Cellular Platform
    Manasa Gadde, Melika Mehrabi-Dehdezi, Bisrat G. Debeb, Wendy A. Woodward, Marissa Nichole Rylander
    Cancers.2023; 15(19): 4883.     CrossRef
  • The Prognosis of Cancer Depends on the Interplay of Autophagy, Apoptosis, and Anoikis within the Tumor Microenvironment
    Shweta Gulia, Prakash Chandra, Asmita Das
    Cell Biochemistry and Biophysics.2023; 81(4): 621.     CrossRef
  • Comprehensive analysis of BTNL9 as a prognostic biomarker correlated with immune infiltrations in thyroid cancer
    Luyao Zhang, Shuang Yu, Shubin Hong, Xi Xiao, Zhihong Liao, Yanbing Li, Haipeng Xiao
    BMC Medical Genomics.2023;[Epub]     CrossRef
  • FF-10850, a Novel Liposomal Topotecan Achieves Superior Antitumor Activity via Macrophage- and Ammonia-Mediated Payload Release in the Tumor Microenvironment
    Susumu Shimoyama, Ken Okada, Toshifumi Kimura, Yasushi Morohashi, Shinji Nakayama, Sayaka Kemmochi, Keiko Makita-Suzuki, Ursula A. Matulonis, Mikinaga Mori
    Molecular Cancer Therapeutics.2023; 22(12): 1454.     CrossRef
  • Estrogen-related genes for thyroid cancer prognosis, immune infiltration, staging, and drug sensitivity
    Leiying Zhang, Man Zhou, Xiaoni Gao, Yang Xie, Junqi Xiao, Tao Liu, Xiangtai Zeng
    BMC Cancer.2023;[Epub]     CrossRef
  • Harnessing Immunity to Treat Advanced Thyroid Cancer
    Hiroki Komatsuda, Michihisa Kono, Risa Wakisaka, Ryosuke Sato, Takahiro Inoue, Takumi Kumai, Miki Takahara
    Vaccines.2023; 12(1): 45.     CrossRef
  • Are third-generation active-targeting nanoformulations definitely the best? In vitro and in vivo comparisons of pixantrone-loaded liposomes modified with different sialic acid derivatives
    Yanzhi Song, Zhennan She, Zhenjun Huang, Shuo Wang, Xinrong Liu, Qi Zhang, Jing Sun, Donghua Di, Yihui Deng
    Drug Delivery and Translational Research.2022; 12(3): 647.     CrossRef
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    X. Shi, L. Shu, Y. Qiao, J. Yao, H. Xie, L. Zhou, H. Wang, S. Zheng
    Materials Today Nano.2022; 17: 100155.     CrossRef
  • Polypharmacologic Reprogramming of Tumor-Associated Macrophages toward an Inflammatory Phenotype
    Nao Nishida-Aoki, Taranjit S. Gujral
    Cancer Research.2022; 82(3): 433.     CrossRef
  • Role of Suprabasin in the Dedifferentiation of Follicular Epithelial Cell-Derived Thyroid Cancer and Identification of Related Immune Markers
    Hao Tan, Lidong Wang, Zhen Liu
    Frontiers in Genetics.2022;[Epub]     CrossRef
  • Macrophage C/EBPδ Drives Gemcitabine, but Not 5-FU or Paclitaxel, Resistance of Pancreatic Cancer Cells in a Deoxycytidine-Dependent Manner
    C. Arnold Spek, Hella L. Aberson, JanWillem Duitman
    Biomedicines.2022; 10(2): 219.     CrossRef
  • Anaplastic Thyroid Carcinoma: An Update
    Arnaud Jannin, Alexandre Escande, Abir Al Ghuzlan, Pierre Blanchard, Dana Hartl, Benjamin Chevalier, Frédéric Deschamps, Livia Lamartina, Ludovic Lacroix, Corinne Dupuy, Eric Baudin, Christine Do Cao, Julien Hadoux
    Cancers.2022; 14(4): 1061.     CrossRef
  • LC3-associated phagocytosis in bone marrow macrophages suppresses acute myeloid leukemia progression through STING activation
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    Journal of Clinical Investigation.2022;[Epub]     CrossRef
  • Integration of chemokine signaling with non-coding RNAs in tumor microenvironment and heterogeneity in different cancers
    Shweta Arora, Salman Khan, Almaz Zaki, Gulnaz Tabassum, Mohd Mohsin, Humaira Naaz Bhutto, Tanveer Ahmad, Tasneem Fatma, Mansoor Ali Syed
    Seminars in Cancer Biology.2022; 86: 720.     CrossRef
  • BRAFV600E Induction in Thyrocytes Triggers Important Changes in the miRNAs Content and the Populations of Extracellular Vesicles Released in Thyroid Tumor Microenvironment
    Ophélie Delcorte, Catherine Spourquet, Pascale Lemoine, Jonathan Degosserie, Patrick Van Der Smissen, Nicolas Dauguet, Axelle Loriot, Jeffrey A. Knauf, Laurent Gatto, Etienne Marbaix, James A. Fagin, Christophe E. Pierreux
    Biomedicines.2022; 10(4): 755.     CrossRef
  • Inflammatory Tumor Microenvironment in Cranial Meningiomas: Clinical Implications and Intraindividual Reproducibility
    Johannes Wach, Tim Lampmann, Ági Güresir, Hartmut Vatter, Ulrich Herrlinger, Albert Becker, Marieta Toma, Michael Hölzel, Erdem Güresir
    Diagnostics.2022; 12(4): 853.     CrossRef
  • Roles and new Insights of Macrophages in the Tumor Microenvironment of Thyroid Cancer
    Qi Liu, Wei Sun, Hao Zhang
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Fucoxanthin Is a Potential Therapeutic Agent for the Treatment of Breast Cancer
    Tsz-Ying Lau, Hiu-Yee Kwan
    Marine Drugs.2022; 20(6): 370.     CrossRef
  • Dissecting Immunosuppressive Cell Communication Patterns Reveals JunB Proto-Oncogene (JUNB) Shaping a Non-Inflamed Tumor Microenvironment
    Hualin Chen, Gang Chen
    Frontiers in Genetics.2022;[Epub]     CrossRef
  • LIMK1: A promising prognostic and immune infiltration indicator in colorectal cancer
    Xin Liu, Qiang Song, Daohan Wang, Yubiao Liu, Zhixiang Zhang, Weihua Fu
    Oncology Letters.2022;[Epub]     CrossRef
  • Unusual Association of NF-κB Components in Tumor-Associated Macrophages (TAMs) Promotes HSPG2-Mediated Immune-Escaping Mechanism in Breast Cancer
    Veronica De Paolis, Fabio Maiullari, Maila Chirivì, Marika Milan, Chiara Cordiglieri, Francesca Pagano, Alessandra Rita La Manna, Elena De Falco, Claudia Bearzi, Roberto Rizzi, Chiara Parisi
    International Journal of Molecular Sciences.2022; 23(14): 7902.     CrossRef
  • Crosstalk between angiogenesis and immune regulation in the tumor microenvironment
    Hei Jung Kim, Young Rae Ji, You Mie Lee
    Archives of Pharmacal Research.2022; 45(6): 401.     CrossRef
  • Cancer Resistance to Immunotherapy: Molecular Mechanisms and Tackling Strategies
    Son Hai Vu, Preethi Vetrivel, Jongmin Kim, Myeong-Sok Lee
    International Journal of Molecular Sciences.2022; 23(18): 10906.     CrossRef
  • Transcription Factor MAFB as a Prognostic Biomarker for the Lung Adenocarcinoma
    Omar Samir, Naohiro Kobayashi, Teppei Nishino, Mennatullah Siyam, Manoj Kumar Yadav, Yuri Inoue, Satoru Takahashi, Michito Hamada
    International Journal of Molecular Sciences.2022; 23(17): 9945.     CrossRef
  • Construction and Validation of a CNV-Driven Ferroptosis-Related Gene Signature for Predicting the Prognosis of Lung Adenocarcinoma
    Yanqing Wang, Yi Zhao, Yong Li, Zemin Luo, Hongzhu Chen, Yuan Li
    Journal of Sensors.2022; 2022: 1.     CrossRef
  • CXCL12 derived from CD248-expressing cancer-associated fibroblasts mediates M2-polarized macrophages to promote nonsmall cell lung cancer progression
    Jieheng Wu, Xinlei Liu, Jiangwei Wu, Chunju Lou, Qiaoling Zhang, Huiping Chen, Zeyang Yang, Shiqi Long, Yun Wang, Zhenling Shang, Zuquan Hu, Rui Zhang, Jian Zhang, Zhu Zeng
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2022; 1868(11): 166521.     CrossRef
  • Cell Component and Function of Tumor Microenvironment in Thyroid Cancer
    Eunah Shin, Ja Seung Koo
    International Journal of Molecular Sciences.2022; 23(20): 12578.     CrossRef
  • TIM3 Expression in Anaplastic-Thyroid-Cancer-Infiltrating Macrophages: An Emerging Immunotherapeutic Target
    Luz Maria Palacios, Victoria Peyret, María Estefania Viano, Romina Celeste Geysels, Yair Aron Chocobar, Ximena Volpini, Claudia Gabriela Pellizas, Juan Pablo Nicola, Claudia Cristina Motran, María Cecilia Rodriguez-Galan, Laura Fozzatti
    Biology.2022; 11(11): 1609.     CrossRef
  • Potential diagnostic of lymph node metastasis and prognostic values of TM4SFs in papillary thyroid carcinoma patients
    Kun Wang, Haomin Li, Junyu Zhao, Jinming Yao, Yiran Lu, Jianjun Dong, Jie Bai, Lin Liao
    Frontiers in Cell and Developmental Biology.2022;[Epub]     CrossRef
  • A distinct M2 macrophage infiltrate and transcriptomic profile decisively influence adipocyte differentiation in lipedema
    Stefan Wolf, Jenna H. Rannikko, Reetta Virtakoivu, Paolo Cinelli, Gunther Felmerer, Anna Burger, Pietro Giovanoli, Michael Detmar, Nicole Lindenblatt, Maija Hollmén, Epameinondas Gousopoulos
    Frontiers in Immunology.2022;[Epub]     CrossRef
  • Macrophage targeting in cancer
    Martha Lopez‐Yrigoyen, Luca Cassetta, Jeffrey W. Pollard
    Annals of the New York Academy of Sciences.2021; 1499(1): 18.     CrossRef
  • Immune Landscape of Thyroid Cancers: New Insights
    Elisa Menicali, Martina Guzzetti, Silvia Morelli, Sonia Moretti, Efisio Puxeddu
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Targeting tumor-associated macrophages to synergize tumor immunotherapy
    Xiaonan Xiang, Jianguo Wang, Di Lu, Xiao Xu
    Signal Transduction and Targeted Therapy.2021;[Epub]     CrossRef
  • FOXE1-Dependent Regulation of Macrophage Chemotaxis by Thyroid Cells In Vitro and In Vivo
    Sara Credendino, Marta De Menna, Irene Cantone, Carmen Moccia, Matteo Esposito, Luigi Di Guida, Mario De Felice, Gabriella De Vita
    International Journal of Molecular Sciences.2021; 22(14): 7666.     CrossRef
  • Hidden Treasures: Macrophage Long Non-Coding RNAs in Lung Cancer Progression
    Annika Karger, Rajender Nandigama, Albrecht Stenzinger, Friedrich Grimminger, Soni Savai Pullamsetti, Werner Seeger, Rajkumar Savai
    Cancers.2021; 13(16): 4127.     CrossRef
  • A Prognostic Role for Circulating microRNAs Involved in Macrophage Polarization in Advanced Non-Small Cell Lung Cancer
    Alexia Monastirioti, Chara Papadaki, Konstantinos Rounis, Despoina Kalapanida, Dimitrios Mavroudis, Sofia Agelaki
    Cells.2021; 10(8): 1988.     CrossRef
  • Hyperglycemia-Induced miR-467 Drives Tumor Inflammation and Growth in Breast Cancer
    Jasmine Gajeton, Irene Krukovets, Santoshi Muppala, Dmitriy Verbovetskiy, Jessica Zhang, Olga Stenina-Adognravi
    Cancers.2021; 13(6): 1346.     CrossRef
  • Targeting MARCO and IL37R on Immunosuppressive Macrophages in Lung Cancer Blocks Regulatory T Cells and Supports Cytotoxic Lymphocyte Function
    Linnéa La Fleur, Johan Botling, Fei He, Catarina Pelicano, Chikai Zhou, Chenfei He, Giorgia Palano, Artur Mezheyeuski, Patrick Micke, Jeffrey V. Ravetch, Mikael C. I. Karlsson, Dhifaf Sarhan
    Cancer Research.2021; 81(4): 956.     CrossRef
  • Absent in melanoma 2-mediating M1 macrophages facilitate tumor rejection in renal carcinoma
    Dafei Chai, Zichun Zhang, Shang yuchen Shi, Dong Qiu, Chen Zhang, Gang Wang, Lin Fang, Huizhong Li, Hui Tian, Hailong Li, Junnian Zheng
    Translational Oncology.2021; 14(4): 101018.     CrossRef
  • Hampering Stromal Cells in the Tumor Microenvironment as a Therapeutic Strategy to Destem Cancer Stem Cells
    Katherine Po Sin Chung, Rainbow Wing Hei Leung, Terence Kin Wah Lee
    Cancers.2021; 13(13): 3191.     CrossRef
  • Thyroid Cancer Stem-Like Cells: From Microenvironmental Niches to Therapeutic Strategies
    Elisa Stellaria Grassi, Viola Ghiandai, Luca Persani
    Journal of Clinical Medicine.2021; 10(7): 1455.     CrossRef
  • Enhanced Drug Delivery to Solid Tumors via Drug-Loaded Nanocarriers: An Image-Based Computational Framework
    Farshad Moradi Kashkooli, M. Soltani, Mohammad Masoud Momeni, Arman Rahmim
    Frontiers in Oncology.2021;[Epub]     CrossRef
  • Mechanisms of primary and acquired resistance to PD-1/PD-L1 blockade and the emerging role of gut microbiome
    R. Zou, Y. Wang, F. Ye, X. Zhang, M. Wang, S. Cui
    Clinical and Translational Oncology.2021; 23(11): 2237.     CrossRef
  • Role of Tumor-Associated Macrophages in Sarcomas
    Tomohiro Fujiwara, John Healey, Koichi Ogura, Aki Yoshida, Hiroya Kondo, Toshiaki Hata, Miho Kure, Hiroshi Tazawa, Eiji Nakata, Toshiyuki Kunisada, Toshiyoshi Fujiwara, Toshifumi Ozaki
    Cancers.2021; 13(5): 1086.     CrossRef
  • Secreted Factors by Anaplastic Thyroid Cancer Cells Induce Tumor-Promoting M2-like Macrophage Polarization through a TIM3-Dependent Mechanism
    Cinthia Carolina Stempin, Romina Celeste Geysels, Sunmi Park, Luz Maria Palacios, Ximena Volpini, Claudia Cristina Motran, Eva Virginia Acosta Rodríguez, Juan Pablo Nicola, Sheue-yann Cheng, Claudia Gabriela Pellizas, Laura Fozzatti
    Cancers.2021; 13(19): 4821.     CrossRef
  • Papillary Thyroid Carcinoma Landscape and Its Immunological Link With Hashimoto Thyroiditis at Single-Cell Resolution
    Jun Pan, Fang Ye, Chengxuan Yu, Qinsheng Zhu, Jiaqi Li, Yaohui Zhang, Hedi Tian, Yunjin Yao, Minjie Zhu, Yibin Shen, Feng Zhu, Yingying Wang, Xinhui Zhou, Guoji Guo, Yijun Wu
    Frontiers in Cell and Developmental Biology.2021;[Epub]     CrossRef
  • Evaluation of solid tumor response to sequential treatment cycles via a new computational hybrid approach
    Farshad Moradi Kashkooli, M. Soltani
    Scientific Reports.2021;[Epub]     CrossRef
  • Assessment of outcomes and novel immune biomarkers in metaplastic breast cancer: a single institution retrospective study
    Evan Morgan, Anupama Suresh, Akaansha Ganju, Daniel G. Stover, Robert Wesolowski, Sagar Sardesai, Anne Noonan, Raquel Reinbolt, Jeffrey VanDeusen, Nicole Williams, Mathew A. Cherian, Zaibo Li, Gregory Young, Marilly Palettas, Julie Stephens, Joseph Liu, A
    World Journal of Surgical Oncology.2020;[Epub]     CrossRef
  • Differentiated agonistic antibody targeting CD137 eradicates large tumors without hepatotoxicity
    Ugur Eskiocak, Wilson Guzman, Benjamin Wolf, Christine Cummings, Lauren Milling, Hsin-Jung Wu, Michael Ophir, Conner Lambden, Pearl Bakhru, Dana C. Gilmore, Samantha Ottinger, Lucy Liu, William K. McConaughy, Sunny Q. He, Chao Wang, Cheuk Lun Leung, Jason
    JCI Insight.2020;[Epub]     CrossRef
  • The Tumor Microenvironment: A Milieu Hindering and Obstructing Antitumor Immune Responses
    Alireza Labani-Motlagh, Mehrnoush Ashja-Mahdavi, Angelica Loskog
    Frontiers in Immunology.2020;[Epub]     CrossRef
  • Sevoflurane depletes macrophages from the melanoma microenvironment
    Isabella Sztwiertnia, Judith Schenz, Katharina Bomans, Dominik Schaack, Johanna Ohnesorge, Sandra Tamulyte, Markus A. Weigand, Florian Uhle, Roger Chammas
    PLOS ONE.2020; 15(5): e0233789.     CrossRef
  • Lung cancer aggressiveness in an intermittent hypoxia murine model of postmenopausal sleep apnea
    Marta Torres, Miguel Ángel Martinez-Garcia, Francisco Campos-Rodriguez, David Gozal, Josep M. Montserrat, Daniel Navajas, Ramon Farré, Isaac Almendros
    Menopause.2020; 27(6): 706.     CrossRef
  • Neck Disability and Swallowing Function in Posttreatment Head and Neck Cancer Patients
    Alexandria Harris, Lingyun Lyu, Tamara Wasserman‐Winko, Susan George, Jonas T. Johnson, Marci Lee Nilsen
    Otolaryngology–Head and Neck Surgery.2020; 163(4): 763.     CrossRef
  • Metabolic modulation via mTOR pathway and anti-angiogenesis remodels tumor microenvironment using PD-L1-targeting codelivery
    Binfan Chen, Ang Gao, Bin Tu, Yonghui Wang, Xiaolu Yu, Yingshu Wang, Yanfeng Xiu, Bing Wang, Yakun Wan, Yongzhuo Huang
    Biomaterials.2020; 255: 120187.     CrossRef
  • The Thyroid Tumor Microenvironment: Potential Targets for Therapeutic Intervention and Prognostication
    Laura MacDonald, Jonathan Jenkins, Grace Purvis, Joshua Lee, Aime T. Franco
    Hormones and Cancer.2020; 11(5-6): 205.     CrossRef
  • The Contribution of Race to Breast Tumor Microenvironment Composition and Disease Progression
    Gina Kim, Jessica M. Pastoriza, John S. Condeelis, Joseph A. Sparano, Panagiota S. Filippou, George S. Karagiannis, Maja H. Oktay
    Frontiers in Oncology.2020;[Epub]     CrossRef
  • Prognosis of Macrophage Density in the Absence of Neutrophils in Differentiated Thyroid Cancer
    Amblessed E. Onuma, Lynn Schoenfield, Chengli Shen, Charity Edwards, John E. Phay, Lawrence A. Shirley, Allan Tsung
    Journal of Surgical Research.2020; 256: 458.     CrossRef
  • Targeting of CD163+ Macrophages in Inflammatory and Malignant Diseases
    Maria K. Skytthe, Jonas Heilskov Graversen, Søren K. Moestrup
    International Journal of Molecular Sciences.2020; 21(15): 5497.     CrossRef
  • Synthetic chlorin derivative self-prevented from aggregation: Behavior in homogeneous medium for PDT applications
    Bianca Martins Estevão, Camila Fabiano de Freitas, Douglas Santana Franciscato, Francisco Fávaro de Assis, Kleber Thiago de Oliveira, Noboru Hioka, Wilker Caetano, Edvani Curti Muniz
    Journal of Molecular Liquids.2020; 320: 114363.     CrossRef
  • Tumor‑associated macrophages in lung cancer: Friendly or evil? (Review)
    Fei Xu, Ying Wei, Zhao Tang, Baojun Liu, Jingcheng Dong
    Molecular Medicine Reports.2020;[Epub]     CrossRef
  • Macrophage-secreted MMP9 induces mesenchymal transition in pancreatic cancer cells via PAR1 activation
    Cansu Tekin, Hella L Aberson, Cynthia Waasdorp, Gerrit K J Hooijer, Onno J de Boer, Frederike Dijk, Maarten F Bijlsma, C Arnold Spek
    Cellular Oncology.2020; 43(6): 1161.     CrossRef
  • Cancer Stem Cells in Thyroid Tumors: From the Origin to Metastasis
    Veronica Veschi, Francesco Verona, Melania Lo Iacono, Caterina D'Accardo, Gaetana Porcelli, Alice Turdo, Miriam Gaggianesi, Stefano Forte, Dario Giuffrida, Lorenzo Memeo, Matilde Todaro
    Frontiers in Endocrinology.2020;[Epub]     CrossRef
  • The Crosstalk Between Tumor-Associated Macrophages (TAMs) and Tumor Cells and the Corresponding Targeted Therapy
    Zhe Ge, Shuzhe Ding
    Frontiers in Oncology.2020;[Epub]     CrossRef
  • Immune Cell Confrontation in the Papillary Thyroid Carcinoma Microenvironment
    Zhenyu Xie, Xin Li, Yuzhen He, Song Wu, Shiyue Wang, Jianjian Sun, Yuchen He, Yu Lun, Jian Zhang
    Frontiers in Endocrinology.2020;[Epub]     CrossRef
  • Early macrophage infiltrates impair pancreatic cancer cell growth by TNF-α secretion
    Cansu Tekin, Hella L. Aberson, Maarten F. Bijlsma, C. Arnold Spek
    BMC Cancer.2020;[Epub]     CrossRef
  • Attenuation of CD47-SIRPα Signal in Cholangiocarcinoma Potentiates Tumor-Associated Macrophage-Mediated Phagocytosis and Suppresses Intrahepatic Metastasis
    Kulthida Vaeteewoottacharn, Ryusho Kariya, Phattarin Pothipan, Sawako Fujikawa, Chawalit Pairojkul, Sakda Waraasawapati, Kazuhiko Kuwahara, Chaisiri Wongkham, Sopit Wongkham, Seiji Okada
    Translational Oncology.2019; 12(2): 217.     CrossRef
  • Circulating CEA‐dNLR score predicts clinical outcome of metastatic gallbladder cancer patient
    Jing‐Hui Du, Jun Lu
    Journal of Clinical Laboratory Analysis.2019;[Epub]     CrossRef
  • The Interplay between MicroRNAs and Cellular Components of Tumour Microenvironment (TME) on Non-Small-Cell Lung Cancer (NSCLC) Progression
    Sook Shien Lee, Yoke Kqueen Cheah
    Journal of Immunology Research.2019; 2019: 1.     CrossRef
  • Papillary thyroid carcinoma behavior: clues in the tumor microenvironment
    Kensey Bergdorf, Donna C Ferguson, Mitra Mehrad, Kim Ely, Thomas Stricker, Vivian L Weiss
    Endocrine-Related Cancer.2019; 26(6): 601.     CrossRef
  • Interplay between thyroid cancer cells and macrophages: effects on IL-32 mediated cell death and thyroid cancer cell migration
    Yvette J. E. Sloot, Katrin Rabold, Thomas Ulas, Dennis M. De Graaf, Bas Heinhuis, Kristian Händler, Joachim L. Schultze, Mihai G. Netea, Johannes W. A. Smit, Leo A. B. Joosten, Romana T. Netea-Maier
    Cellular Oncology.2019; 42(5): 691.     CrossRef
  • Iron accumulation in tumor-associated macrophages marks an improved overall survival in patients with lung adenocarcinoma
    Carl Maximilian Thielmann, Milene Costa da Silva, Thomas Muley, Michael Meister, Esther Herpel, Martina U. Muckenthaler
    Scientific Reports.2019;[Epub]     CrossRef
  • The Immune Landscape of Thyroid Cancer in the Context of Immune Checkpoint Inhibition
    Gilda Varricchi, Stefania Loffredo, Giancarlo Marone, Luca Modestino, Poupak Fallahi, Silvia Martina Ferrari, Amato de Paulis, Alessandro Antonelli, Maria Rosaria Galdiero
    International Journal of Molecular Sciences.2019; 20(16): 3934.     CrossRef
  • A review on the role of M2 macrophages in bladder cancer; pathophysiology and targeting
    Laleh Sharifi, Mohammad Reza Nowroozi, Erfan Amini, Masoumeh Kourosh Arami, Mohsen Ayati, Monireh Mohsenzadegan
    International Immunopharmacology.2019; 76: 105880.     CrossRef
  • Tumor-associated macrophage infiltration in meningioma
    Dustin T Proctor, Jordan Huang, Sanju Lama, Abdulrahman Albakr, Guido Van Marle, Garnette R Sutherland
    Neuro-Oncology Advances.2019;[Epub]     CrossRef
  • Immune and Inflammatory Cells in Thyroid Cancer Microenvironment
    Ferrari, Fallahi, Galdiero, Ruffilli, Elia, Ragusa, Paparo, Patrizio, Mazzi, Varricchi, Marone, Antonelli
    International Journal of Molecular Sciences.2019; 20(18): 4413.     CrossRef
  • Caveolin-2 deficiency induces a rapid anti-tumor immune response prior to regression of implanted murine lung carcinoma tumors
    Yajun Liu, Xiaoqiang Qi, Guangfu Li, Grzegorz Sowa
    Scientific Reports.2019;[Epub]     CrossRef
  • Paclitaxel Treatment and Proprotein Convertase 1/3 (PC1/3) Knockdown in Macrophages is a Promising Antiglioma Strategy as Revealed by Proteomics and Cytotoxicity Studies
    Marie Duhamel, Mélanie Rose, Franck Rodet, Adriana Natalia Murgoci, Lea Zografidou, Anne Régnier-Vigouroux, Fabien Vanden Abeele, Firas Kobeissy, Serge Nataf, Laurent Pays, Maxence Wisztorski, Dasa Cizkova, Isabelle Fournier, Michel Salzet
    Molecular & Cellular Proteomics.2018; 17(6): 1126.     CrossRef
  • Chloroquine and nanoparticle drug delivery: A promising combination
    Joe Pelt, Sara Busatto, Mauro Ferrari, E. Aubrey Thompson, Kabir Mody, Joy Wolfram
    Pharmacology & Therapeutics.2018; 191: 43.     CrossRef
  • Conditioned medium from stimulated macrophages inhibits growth but induces an inflammatory phenotype in breast cancer cells
    Wenzhe Song, Parth Thakor, David A. Vesey, Glenda C. Gobe, Christudas Morais
    Biomedicine & Pharmacotherapy.2018; 106: 247.     CrossRef
  • Potential involvement of neutrophils in human thyroid cancer
    Maria Rosaria Galdiero, Gilda Varricchi, Stefania Loffredo, Claudio Bellevicine, Tiziana Lansione, Anne Lise Ferrara, Raffaella Iannone, Sarah di Somma, Francesco Borriello, Eduardo Clery, Maria Triassi, Giancarlo Troncone, Gianni Marone, Fabrizio Mattei
    PLOS ONE.2018; 13(6): e0199740.     CrossRef
  • CSF1R-Expressing Tumor-Associated Macrophages, Smoking and Survival in Lung Adenocarcinoma: Analyses Using Quantitative Phosphor-Integrated Dot Staining
    Kentaro Inamura, Yasuyuki Shigematsu, Hironori Ninomiya, Yasuhiro Nakashima, Maki Kobayashi, Haruyuki Saito, Katsuhiro Takahashi, Etsuko Futaya, Sakae Okumura, Yuichi Ishikawa, Hiroaki Kanda
    Cancers.2018; 10(8): 252.     CrossRef
  • Tumor heterogeneity and nanoparticle-mediated tumor targeting: the importance of delivery system personalization
    K. Laxmi Swetha, Aniruddha Roy
    Drug Delivery and Translational Research.2018; 8(5): 1508.     CrossRef
  • Immune Gene Signature Delineates a Subclass of Papillary Thyroid Cancer with Unfavorable Clinical Outcomes
    Kyuryung Kim, Sora Jeon, Tae-Min Kim, Chan Jung
    Cancers.2018; 10(12): 494.     CrossRef
  • Bone marrow-derived cells are recruited by the melanoma tumor with endothelial cells contributing to tumor vasculature
    R. Bonfim-Silva, L. E. B. Souza, F. U. F. Melo, V. C. Oliveira, D. A. R. Magalhães, H. F. Oliveira, D. T. Covas, A. M. Fontes
    Clinical and Translational Oncology.2017; 19(1): 125.     CrossRef
  • Stromal contributions to the carcinogenic process
    Mark Spaw, Shrikant Anant, Sufi Mary Thomas
    Molecular Carcinogenesis.2017; 56(4): 1199.     CrossRef
  • The Role of Cancer-Associated Fibroblasts and Fibrosis in Liver Cancer
    Silvia Affo, Le-Xing Yu, Robert F. Schwabe
    Annual Review of Pathology: Mechanisms of Disease.2017; 12(1): 153.     CrossRef
  • PEDF increases the tumoricidal activity of macrophages towards prostate cancer cells in vitro
    Dalia Martinez-Marin, Courtney Jarvis, Thomas Nelius, Werner de Riese, Olga V. Volpert, Stéphanie Filleur, Chih-Hsin Tang
    PLOS ONE.2017; 12(4): e0174968.     CrossRef
  • Anaplastic thyroid carcinoma: from clinicopathology to genetics and advanced therapies
    Eleonora Molinaro, Cristina Romei, Agnese Biagini, Elena Sabini, Laura Agate, Salvatore Mazzeo, Gabriele Materazzi, Stefano Sellari-Franceschini, Alessandro Ribechini, Liborio Torregrossa, Fulvio Basolo, Paolo Vitti, Rossella Elisei
    Nature Reviews Endocrinology.2017; 13(11): 644.     CrossRef
  • Iron Induces Anti-tumor Activity in Tumor-Associated Macrophages
    Milene Costa da Silva, Michael O. Breckwoldt, Francesca Vinchi, Margareta P. Correia, Ana Stojanovic, Carl Maximilian Thielmann, Michael Meister, Thomas Muley, Arne Warth, Michael Platten, Matthias W. Hentze, Adelheid Cerwenka, Martina U. Muckenthaler
    Frontiers in Immunology.2017;[Epub]     CrossRef
  • Reprogramming Tumor-Associated Macrophages To Reverse EGFRT790M Resistance by Dual-Targeting Codelivery of Gefitinib/Vorinostat
    Huige Peng, Binfan Chen, Wei Huang, Yubo Tang, Yifan Jiang, Wenyuan Zhang, Yongzhuo Huang
    Nano Letters.2017; 17(12): 7684.     CrossRef
  • Numerical modeling of nanodrug distribution in tumors with heterogeneous vasculature
    Cheng-Ying Chou, Wan-I Chang, Tzyy-Leng Horng, Win-Li Lin, Han-Chung Wu
    PLOS ONE.2017; 12(12): e0189802.     CrossRef
  • HPMA–Copolymer Nanocarrier Targets Tumor-Associated Macrophages in Primary and Metastatic Breast Cancer
    Melissa N. Zimel, Chloe B. Horowitz, Vinagolu K. Rajasekhar, Alexander B. Christ, Xin Wei, Jianbo Wu, Paulina M. Wojnarowicz, Dong Wang, Steven R. Goldring, P. Edward Purdue, John H. Healey
    Molecular Cancer Therapeutics.2017; 16(12): 2701.     CrossRef
  • Correlation of tumor-associated macrophages and NK cells with bladder cancer size and T stage in patients with solitary low-grade urothelial carcinoma
    Kristian Krpina, Emina Babarović, Josip Španjol, Gordana Đorđević, Tobias Maurer, Nives Jonjić
    Wiener klinische Wochenschrift.2016; 128(7-8): 248.     CrossRef
  • The lymphatic system and pancreatic cancer
    Darci M. Fink, Maria M. Steele, Michael A. Hollingsworth
    Cancer Letters.2016; 381(1): 217.     CrossRef
  • Jacalin-Activated Macrophages Exhibit an Antitumor Phenotype
    Cláudia Danella Polli, Luciana Pereira Ruas, Luciana Chain Veronez, Thais Herrero Geraldino, Fabiana Rossetto de Morais, Maria Cristina Roque-Barreira, Gabriela Pereira-da-Silva
    BioMed Research International.2016; 2016: 1.     CrossRef
  • The immune network in thyroid cancer
    Maria Rosaria Galdiero, Gilda Varricchi, Gianni Marone
    OncoImmunology.2016; 5(6): e1168556.     CrossRef
  • The Expression and Relationship of CD68-Tumor-Associated Macrophages and Microvascular Density With the Prognosis of Patients With Laryngeal Squamous Cell Carcinoma
    Shujun Sun, Xinliang Pan, Limin Zhao, Jianming Zhou, Hongzeng Wang, Yonghong Sun
    Clinical and Experimental Otorhinolaryngology.2016; 9(3): 270.     CrossRef
  • Role of pulmonary macrophages in initiation of lung metastasis in anaplastic thyroid cancer
    Xiu Juan Li, Prakash Gangadaran, Senthilkumar Kalimuthu, Ji Min Oh, Liya Zhu, Shin Young Jeong, Sang‐Woo Lee, Jaetae Lee, Byeong‐Cheol Ahn
    International Journal of Cancer.2016; 139(11): 2583.     CrossRef
  • Perspectives for immunotherapy in endocrine cancer
    S Latteyer, V Tiedje, B Schilling, D Führer
    Endocrine-Related Cancer.2016; 23(10): R469.     CrossRef
  • Macrophage Densities Correlated with CXC Chemokine Receptor 4 Expression and Related with Poor Survival in Anaplastic Thyroid Cancer
    Dae In Kim, Eunyoung Kim, Young A Kim, Sun Wook Cho, Jung Ah Lim, Young Joo Park
    Endocrinology and Metabolism.2016; 31(3): 469.     CrossRef
  • High expression of C-C chemokine receptor 2 associates with poor overall survival in gastric cancer patients after surgical resection
    Ruochen Li, Heng Zhang, Hao Liu, Chao Lin, Yifan Cao, Weijuan Zhang, Zhenbin Shen, Jiejie Xu
    Oncotarget.2016; 7(17): 23909.     CrossRef
  • Polycationic carbosilane dendrimer decreases angiogenesis and tumor-associated macrophages in tumor-bearing mice
    Ana Judith Perisé-Barrios, María Jesús Serramia, Javier de la Mata, Rafael Gomez, Angel Luis Corbí, Ángeles Domínguez-Soto, María Ángeles Muñoz-Fernandez
    RSC Advances.2015; 5(126): 104110.     CrossRef
Reviews
Artificial Intelligence in Pathology
Hye Yoon Chang, Chan Kwon Jung, Junwoo Isaac Woo, Sanghun Lee, Joonyoung Cho, Sun Woo Kim, Tae-Yeong Kwak
J Pathol Transl Med. 2019;53(1):1-12.   Published online December 28, 2018
DOI: https://doi.org/10.4132/jptm.2018.12.16
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AbstractAbstract PDF
As in other domains, artificial intelligence is becoming increasingly important in medicine. In particular,deep learning-based pattern recognition methods can advance the field of pathology byincorporating clinical, radiologic, and genomic data to accurately diagnose diseases and predictpatient prognoses. In this review, we present an overview of artificial intelligence, the brief historyof artificial intelligence in the medical domain, recent advances in artificial intelligence applied topathology, and future prospects of pathology driven by artificial intelligence.

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  • Whole Slide Imaging Technology and Its Applications: Current and Emerging Perspectives
    Ekta Jain, Ankush Patel, Anil V. Parwani, Saba Shafi, Zoya Brar, Shivani Sharma, Sambit K. Mohanty
    International Journal of Surgical Pathology.2024; 32(3): 433.     CrossRef
  • ChatGPT as an aid for pathological diagnosis of cancer
    Shaivy Malik, Sufian Zaheer
    Pathology - Research and Practice.2024; 253: 154989.     CrossRef
  • Computational pathology: A survey review and the way forward
    Mahdi S. Hosseini, Babak Ehteshami Bejnordi, Vincent Quoc-Huy Trinh, Lyndon Chan, Danial Hasan, Xingwen Li, Stephen Yang, Taehyo Kim, Haochen Zhang, Theodore Wu, Kajanan Chinniah, Sina Maghsoudlou, Ryan Zhang, Jiadai Zhu, Samir Khaki, Andrei Buin, Fatemeh
    Journal of Pathology Informatics.2024; 15: 100357.     CrossRef
  • Applications of artificial intelligence in the field of oral and maxillofacial pathology: a systematic review and meta-analysis
    Nishath Sayed Abdul, Ganiga Channaiah Shivakumar, Sunila Bukanakere Sangappa, Marco Di Blasio, Salvatore Crimi, Marco Cicciù, Giuseppe Minervini
    BMC Oral Health.2024;[Epub]     CrossRef
  • Machine-learning models are superior to severity scoring systems for the prediction of the mortality of critically ill patients in a tertiary medical center
    Ruey-Hsing Chou, Benny Wei-Yun Hsu, Chun-Lin Yu, Tai-Yuan Chen, Shuo-Ming Ou, Kuo-Hua Lee, Vincent S. Tseng, Po-Hsun Huang, Der-Cherng Tarng
    Journal of the Chinese Medical Association.2024; 87(4): 369.     CrossRef
  • The Evaluation of Artificial Intelligence Technology for the Differentiation of Fresh Human Blood Cells From Other Species Blood in the Investigation of Crime Scenes
    Syed Sajid Hussain Shah, Ekramy Elmorsy, Rashad Qasem Ali Othman, Asmara Syed, Syed Umar Armaghan, Syed Usama Khalid Bokhari, Mahmoud E Elmorsy, Abdulhakim Bawadekji
    Cureus.2024;[Epub]     CrossRef
  • The Constrained-Disorder Principle Assists in Overcoming Significant Challenges in Digital Health: Moving from “Nice to Have” to Mandatory Systems
    Noa Hurvitz, Yaron Ilan
    Clinics and Practice.2023; 13(4): 994.     CrossRef
  • Building a nonclinical pathology laboratory of the future for pharmaceutical research excellence
    D.G. Rudmann, L. Bertrand, A. Zuraw, J. Deiters, M. Staup, Y. Rivenson, J. Kuklyte
    Drug Discovery Today.2023; 28(10): 103747.     CrossRef
  • Automated image analysis of keratin 7 staining can predict disease outcome in primary sclerosing cholangitis
    Nelli Sjöblom, Sonja Boyd, Anniina Manninen, Sami Blom, Anna Knuuttila, Martti Färkkilä, Johanna Arola
    Hepatology Research.2023; 53(4): 322.     CrossRef
  • Application of convolutional neural network for analyzing hepatic fibrosis in mice
    Hyun-Ji Kim, Eun Bok Baek, Ji-Hee Hwang, Minyoung Lim, Won Hoon Jung, Myung Ae Bae, Hwa-Young Son, Jae-Woo Cho
    Journal of Toxicologic Pathology.2023; 36(1): 21.     CrossRef
  • Machine Learning Techniques for Prognosis Estimation and Knowledge Discovery From Lab Test Results With Application to the COVID-19 Emergency
    Alfonso Emilio Gerevini, Roberto Maroldi, Matteo Olivato, Luca Putelli, Ivan Serina
    IEEE Access.2023; 11: 83905.     CrossRef
  • Artificial intelligence in dentistry—A review
    Hao Ding, Jiamin Wu, Wuyuan Zhao, Jukka P. Matinlinna, Michael F. Burrow, James K. H. Tsoi
    Frontiers in Dental Medicine.2023;[Epub]     CrossRef
  • Dental Age Estimation Using the Demirjian Method: Statistical Analysis Using Neural Networks
    Byung-Yoon Roh, Jong-Seok Lee, Sang-Beom Lim, Hye-Won Ryu, Su-Jeong Jeon, Ju-Heon Lee, Yo-Seob Seo, Ji-Won Ryu, Jong-Mo Ahn
    Korean Journal of Legal Medicine.2023; 47(1): 1.     CrossRef
  • The use of artificial intelligence in health care. Problems of identification of patients' conditions in the processes of detailing the diagnosis
    Mintser O
    Artificial Intelligence.2023; 28(AI.2023.28): 8.     CrossRef
  • The Effectiveness of Data Augmentation for Mature White Blood Cell Image Classification in Deep Learning — Selection of an Optimal Technique for Hematological Morphology Recognition —
    Hiroyuki NOZAKA, Kosuke KAMATA, Kazufumi YAMAGATA
    IEICE Transactions on Information and Systems.2023; E106.D(5): 707.     CrossRef
  • Rectal Cancer Stages T2 and T3 Identification Based on Asymptotic Hybrid Feature Maps
    Shujing Sun, Jiale Wu, Jian Yao, Yang Cheng, Xin Zhang, Zhihua Lu, Pengjiang Qian
    Computer Modeling in Engineering & Sciences.2023; 137(1): 923.     CrossRef
  • How to use AI in pathology
    Peter Schüffler, Katja Steiger, Wilko Weichert
    Genes, Chromosomes and Cancer.2023; 62(9): 564.     CrossRef
  • Cutting-Edge Technologies for Digital Therapeutics: A Review and Architecture Proposals for Future Directions
    Joo Hun Yoo, Harim Jeong, Tai-Myoung Chung
    Applied Sciences.2023; 13(12): 6929.     CrossRef
  • A convolutional neural network STIFMap reveals associations between stromal stiffness and EMT in breast cancer
    Connor Stashko, Mary-Kate Hayward, Jason J. Northey, Neil Pearson, Alastair J. Ironside, Johnathon N. Lakins, Roger Oria, Marie-Anne Goyette, Lakyn Mayo, Hege G. Russnes, E. Shelley Hwang, Matthew L. Kutys, Kornelia Polyak, Valerie M. Weaver
    Nature Communications.2023;[Epub]     CrossRef
  • Artificial Intelligence-Based PTEN Loss Assessment as an Early Predictor of Prostate Cancer Metastasis After Surgery: A Multicenter Retrospective Study
    Palak Patel, Stephanie Harmon, Rachael Iseman, Olga Ludkowski, Heidi Auman, Sarah Hawley, Lisa F. Newcomb, Daniel W. Lin, Peter S. Nelson, Ziding Feng, Hilary D. Boyer, Maria S. Tretiakova, Larry D. True, Funda Vakar-Lopez, Peter R. Carroll, Matthew R. Co
    Modern Pathology.2023; 36(10): 100241.     CrossRef
  • Minimum resolution requirements of digital pathology images for accurate classification
    Lydia Neary-Zajiczek, Linas Beresna, Benjamin Razavi, Vijay Pawar, Michael Shaw, Danail Stoyanov
    Medical Image Analysis.2023; 89: 102891.     CrossRef
  • Artificial Intelligence in the Pathology of Gastric Cancer
    Sangjoon Choi, Seokhwi Kim
    Journal of Gastric Cancer.2023; 23(3): 410.     CrossRef
  • Endoscopic Ultrasound-Based Artificial Intelligence Diagnosis of Pancreatic Cystic Neoplasms
    Jin-Seok Park, Seok Jeong
    The Korean Journal of Pancreas and Biliary Tract.2023; 28(3): 53.     CrossRef
  • Framework for Classifying Explainable Artificial Intelligence (XAI) Algorithms in Clinical Medicine
    Thomas Gniadek, Jason Kang, Talent Theparee, Jacob Krive
    Online Journal of Public Health Informatics.2023; 15: e50934.     CrossRef
  • A Literature Review of the Future of Oral Medicine and Radiology, Oral Pathology, and Oral Surgery in the Hands of Technology
    Ishita Singhal, Geetpriya Kaur, Dirk Neefs, Aparna Pathak
    Cureus.2023;[Epub]     CrossRef
  • AI-Powered Biomolecular-Specific and Label-Free Multispectral Imaging Rapidly Detects Malignant Neoplasm in Surgically Excised Breast Tissue Specimens
    Rishikesh Pandey, David Fournier, Gary Root, Machele Riccio, Aditya Shirvalkar, Gianfranco Zamora, Noel Daigneault, Michael Sapack, Minghao Zhong, Malini Harigopal
    Archives of Pathology & Laboratory Medicine.2023; 147(11): 1298.     CrossRef
  • Exploring the status of artificial intelligence for healthcare research in Africa: a bibliometric and thematic analysis
    Tabu S. Kondo, Salim A. Diwani, Ally S. Nyamawe, Mohamed M. Mjahidi
    AI and Ethics.2023;[Epub]     CrossRef
  • Artificial intelligence for patient scheduling in the real-world health care setting: A metanarrative review
    Dacre R.T. Knight, Christopher A. Aakre, Christopher V. Anstine, Bala Munipalli, Parisa Biazar, Ghada Mitri, Jose Raul Valery, Tara Brigham, Shehzad K. Niazi, Adam I. Perlman, John D. Halamka, Abd Moain Abu Dabrh
    Health Policy and Technology.2023; 12(4): 100824.     CrossRef
  • Towards Autonomous Healthcare: Integrating Artificial Intelligence (AI) for Personalized Medicine and Disease Prediction
    Nitin Rane, Saurabh Choudhary, Jayesh Rane
    SSRN Electronic Journal.2023;[Epub]     CrossRef
  • Medical imaging and multimodal artificial intelligence models for streamlining and enhancing cancer care: opportunities and challenges
    Kevin Pierre, Manas Gupta, Abheek Raviprasad, Seyedeh Mehrsa Sadat Razavi, Anjali Patel, Keith Peters, Bruno Hochhegger, Anthony Mancuso, Reza Forghani
    Expert Review of Anticancer Therapy.2023; 23(12): 1265.     CrossRef
  • Automated differential diagnostics of respiratory diseases using an electronic stethoscope
    Diana Arhypenko, Denis Panaskin, Dmytro Babko
    Polish Journal of Medical Physics and Engineering.2023; 29(4): 208.     CrossRef
  • Application of machine learning in identification of pathogenic microbes
    Lakshmi Venkata S Kutikuppala, Kanishk K Adhit, Reewen George D Silva
    Digital Medicine.2023;[Epub]     CrossRef
  • Automated abstraction of myocardial perfusion imaging reports using natural language processing
    Parija Sharedalal, Ajay Singh, Neal Shah, Diwakar Jain
    Journal of Nuclear Cardiology.2022; 29(3): 1188.     CrossRef
  • Polyploid giant cancer cell characterization: New frontiers in predicting response to chemotherapy in breast cancer
    Geetanjali Saini, Shriya Joshi, Chakravarthy Garlapati, Hongxiao Li, Jun Kong, Jayashree Krishnamurthy, Michelle D. Reid, Ritu Aneja
    Seminars in Cancer Biology.2022; 81: 220.     CrossRef
  • A Comprehensive Review of Markov Random Field and Conditional Random Field Approaches in Pathology Image Analysis
    Yixin Li, Chen Li, Xiaoyan Li, Kai Wang, Md Mamunur Rahaman, Changhao Sun, Hao Chen, Xinran Wu, Hong Zhang, Qian Wang
    Archives of Computational Methods in Engineering.2022; 29(1): 609.     CrossRef
  • Artificial intelligence in oncology: From bench to clinic
    Jamal Elkhader, Olivier Elemento
    Seminars in Cancer Biology.2022; 84: 113.     CrossRef
  • Yeast‐like organisms phagocytosed by circulating neutrophils: Evidence of disseminated histoplasmosis
    Yue Zhao, Jenna McCracken, Endi Wang
    International Journal of Laboratory Hematology.2022; 44(1): 51.     CrossRef
  • Whole-slide imaging, tissue image analysis, and artificial intelligence in veterinary pathology: An updated introduction and review
    Aleksandra Zuraw, Famke Aeffner
    Veterinary Pathology.2022; 59(1): 6.     CrossRef
  • A comprehensive review of computer-aided whole-slide image analysis: from datasets to feature extraction, segmentation, classification and detection approaches
    Xintong Li, Chen Li, Md Mamunur Rahaman, Hongzan Sun, Xiaoqi Li, Jian Wu, Yudong Yao, Marcin Grzegorzek
    Artificial Intelligence Review.2022; 55(6): 4809.     CrossRef
  • Liquid Biopsy and Artificial Intelligence as Tools to Detect Signatures of Colorectal Malignancies: A Modern Approach in Patient’s Stratification
    Octav Ginghina, Ariana Hudita, Marius Zamfir, Andrada Spanu, Mara Mardare, Irina Bondoc, Laura Buburuzan, Sergiu Emil Georgescu, Marieta Costache, Carolina Negrei, Cornelia Nitipir, Bianca Galateanu
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Automated bone marrow cytology using deep learning to generate a histogram of cell types
    Rohollah Moosavi Tayebi, Youqing Mu, Taher Dehkharghanian, Catherine Ross, Monalisa Sur, Ronan Foley, Hamid R. Tizhoosh, Clinton J. V. Campbell
    Communications Medicine.2022;[Epub]     CrossRef
  • Risultati di esami di laboratorio per intelligenza artificiale e "machine learning"
    Marco PRADELLA
    La Rivista Italiana della Medicina di Laboratorio.2022;[Epub]     CrossRef
  • The Deception of Certainty: how Non-Interpretable Machine Learning Outcomes Challenge the Epistemic Authority of Physicians. A deliberative-relational Approach
    Florian Funer
    Medicine, Health Care and Philosophy.2022; 25(2): 167.     CrossRef
  • Deep discriminative learning model with calibrated attention map for the automated diagnosis of diffuse large B-cell lymphoma
    Sautami Basu, Ravinder Agarwal, Vishal Srivastava
    Biomedical Signal Processing and Control.2022; 76: 103728.     CrossRef
  • Question and Answer Techniques for Financial Audits in Universities Based on Deep Learning
    Qiang Li, Hangjun Che
    Mathematical Problems in Engineering.2022; 2022: 1.     CrossRef
  • Noninvasive Screening Tool for Hyperkalemia Using a Single-Lead Electrocardiogram and Deep Learning: Development and Usability Study
    Erdenebayar Urtnasan, Jung Hun Lee, Byungjin Moon, Hee Young Lee, Kyuhee Lee, Hyun Youk
    JMIR Medical Informatics.2022; 10(6): e34724.     CrossRef
  • Impact of artificial intelligence on pathologists’ decisions: an experiment
    Julien Meyer, April Khademi, Bernard Têtu, Wencui Han, Pria Nippak, David Remisch
    Journal of the American Medical Informatics Association.2022; 29(10): 1688.     CrossRef
  • Rapid Screening Using Pathomorphologic Interpretation to Detect BRAFV600E Mutation and Microsatellite Instability in Colorectal Cancer
    Satoshi Fujii, Daisuke Kotani, Masahiro Hattori, Masato Nishihara, Toshihide Shikanai, Junji Hashimoto, Yuki Hama, Takuya Nishino, Mizuto Suzuki, Ayatoshi Yoshidumi, Makoto Ueno, Yoshito Komatsu, Toshiki Masuishi, Hiroki Hara, Taito Esaki, Yoshiaki Nakamu
    Clinical Cancer Research.2022; 28(12): 2623.     CrossRef
  • Using Deep Learning to Predict Final HER2 Status in Invasive Breast Cancers That are Equivocal (2+) by Immunohistochemistry
    Sean A. Rasmussen, Valerie J. Taylor, Alexi P. Surette, Penny J. Barnes, Gillian C. Bethune
    Applied Immunohistochemistry & Molecular Morphology.2022; 30(10): 668.     CrossRef
  • Deep Neural Network for the Prediction of KRAS Genotype in Rectal Cancer
    Waleed M Ghareeb, Eman Draz, Khaled Madbouly, Ahmed H Hussein, Mohammed Faisal, Wagdi Elkashef, Mona Hany Emile, Marcus Edelhamre, Seon Hahn Kim, Sameh Hany Emile
    Journal of the American College of Surgeons.2022; 235(3): 482.     CrossRef
  • Next Generation Digital Pathology: Emerging Trends and Measurement Challenges for Molecular Pathology
    Alex Dexter, Dimitrios Tsikritsis, Natalie A. Belsey, Spencer A. Thomas, Jenny Venton, Josephine Bunch, Marina Romanchikova
    Journal of Molecular Pathology.2022; 3(3): 168.     CrossRef
  • Animation Design of Multisensor Data Fusion Based on Optimized AVOD Algorithm
    Li Ding, Guobing Wei, Kai Zhang, Gengxin Sun
    Journal of Sensors.2022; 2022: 1.     CrossRef
  • Study on Machine Translation Teaching Model Based on Translation Parallel Corpus and Exploitation for Multimedia Asian Information Processing
    Yan Gong
    ACM Transactions on Asian and Low-Resource Language Information Processing.2022;[Epub]     CrossRef
  • Analysis and Estimation of Pathological Data and Findings with Deep Learning Methods
    Ahmet Anıl ŞAKIR, Ali Hakan IŞIK, Özlem ÖZMEN, Volkan İPEK
    Veterinary Journal of Mehmet Akif Ersoy University.2022; 7(3): 175.     CrossRef
  • Artificial Intelligence in Pathology: Friend or Enemy?
    Selim Sevim, Ezgi Dicle Serbes, Murat Bahadır, Mustafa Said Kartal, Serpil Dizbay Sak
    Journal of Ankara University Faculty of Medicine.2022; 75(1): 13.     CrossRef
  • Evaluation Challenges in the Validation of B7-H3 as Oral Tongue Cancer Prognosticator
    Meri Sieviläinen, Anna Maria Wirsing, Aini Hyytiäinen, Rabeia Almahmoudi, Priscila Rodrigues, Inger-Heidi Bjerkli, Pirjo Åström, Sanna Toppila-Salmi, Timo Paavonen, Ricardo D. Coletta, Elin Hadler-Olsen, Tuula Salo, Ahmed Al-Samadi
    Head and Neck Pathology.2021; 15(2): 469.     CrossRef
  • Amsterdam International Consensus Meeting: tumor response scoring in the pathology assessment of resected pancreatic cancer after neoadjuvant therapy
    Boris V. Janssen, Faik Tutucu, Stijn van Roessel, Volkan Adsay, Olca Basturk, Fiona Campbell, Claudio Doglioni, Irene Esposito, Roger Feakins, Noriyoshi Fukushima, Anthony J. Gill, Ralph H. Hruban, Jeffrey Kaplan, Bas Groot Koerkamp, Seung-Mo Hong, Alyssa
    Modern Pathology.2021; 34(1): 4.     CrossRef
  • Fabrication of ultra-thin 2D covalent organic framework nanosheets and their application in functional electronic devices
    Weikang Wang, Weiwei Zhao, Haotian Xu, Shujuan Liu, Wei Huang, Qiang Zhao
    Coordination Chemistry Reviews.2021; 429: 213616.     CrossRef
  • Generalizability of Deep Learning System for the Pathologic Diagnosis of Various Cancers
    Hyun-Jong Jang, In Hye Song, Sung Hak Lee
    Applied Sciences.2021; 11(2): 808.     CrossRef
  • Integrated digital pathology at scale: A solution for clinical diagnostics and cancer research at a large academic medical center
    Peter J Schüffler, Luke Geneslaw, D Vijay K Yarlagadda, Matthew G Hanna, Jennifer Samboy, Evangelos Stamelos, Chad Vanderbilt, John Philip, Marc-Henri Jean, Lorraine Corsale, Allyne Manzo, Neeraj H G Paramasivam, John S Ziegler, Jianjiong Gao, Juan C Peri
    Journal of the American Medical Informatics Association.2021; 28(9): 1874.     CrossRef
  • Translational Applications of Artificial Intelligence and Machine Learning for Diagnostic Pathology in Lymphoid Neoplasms: A Comprehensive and Evolutive Analysis
    Julia Moran-Sanchez, Antonio Santisteban-Espejo, Miguel Angel Martin-Piedra, Jose Perez-Requena, Marcial Garcia-Rojo
    Biomolecules.2021; 11(6): 793.     CrossRef
  • Development and operation of a digital platform for sharing pathology image data
    Yunsook Kang, Yoo Jung Kim, Seongkeun Park, Gun Ro, Choyeon Hong, Hyungjoon Jang, Sungduk Cho, Won Jae Hong, Dong Un Kang, Jonghoon Chun, Kyoungbun Lee, Gyeong Hoon Kang, Kyoung Chul Moon, Gheeyoung Choe, Kyu Sang Lee, Jeong Hwan Park, Won-Ki Jeong, Se Yo
    BMC Medical Informatics and Decision Making.2021;[Epub]     CrossRef
  • Sliding window based deep ensemble system for breast cancer classification
    Amin Alqudah, Ali Mohammad Alqudah
    Journal of Medical Engineering & Technology.2021; 45(4): 313.     CrossRef
  • Artificial intelligence and computational pathology
    Miao Cui, David Y. Zhang
    Laboratory Investigation.2021; 101(4): 412.     CrossRef
  • Effects of Image Quantity and Image Source Variation on Machine Learning Histology Differential Diagnosis Models
    Elham Vali-Betts, Kevin J. Krause, Alanna Dubrovsky, Kristin Olson, John Paul Graff, Anupam Mitra, Ananya Datta-Mitra, Kenneth Beck, Aristotelis Tsirigos, Cynthia Loomis, Antonio Galvao Neto, Esther Adler, Hooman H. Rashidi
    Journal of Pathology Informatics.2021; 12(1): 5.     CrossRef
  • Feasibility of deep learning‐based fully automated classification of microsatellite instability in tissue slides of colorectal cancer
    Sung Hak Lee, In Hye Song, Hyun‐Jong Jang
    International Journal of Cancer.2021; 149(3): 728.     CrossRef
  • Artificial intelligence in healthcare
    Yamini D Shah, Shailvi M Soni, Manish P Patel
    Indian Journal of Pharmacy and Pharmacology.2021; 8(2): 102.     CrossRef
  • Proof of Concept for a Deep Learning Algorithm for Identification and Quantification of Key Microscopic Features in the Murine Model of DSS-Induced Colitis
    Agathe Bédard, Thomas Westerling-Bui, Aleksandra Zuraw
    Toxicologic Pathology.2021; 49(4): 897.     CrossRef
  • An empirical analysis of machine learning frameworks for digital pathology in medical science
    S.K.B. Sangeetha, R Dhaya, Dhruv T Shah, R Dharanidharan, K. Praneeth Sai Reddy
    Journal of Physics: Conference Series.2021; 1767(1): 012031.     CrossRef
  • Application of Single-Cell Approaches to Study Myeloproliferative Neoplasm Biology
    Daniel Royston, Adam J. Mead, Bethan Psaila
    Hematology/Oncology Clinics of North America.2021; 35(2): 279.     CrossRef
  • Idiosyncratic Drug-Induced Liver Injury (DILI) and Herb-Induced Liver Injury (HILI): Diagnostic Algorithm Based on the Quantitative Roussel Uclaf Causality Assessment Method (RUCAM)
    Rolf Teschke, Gaby Danan
    Diagnostics.2021; 11(3): 458.     CrossRef
  • Searching Images for Consensus
    Hamid R. Tizhoosh, Phedias Diamandis, Clinton J.V. Campbell, Amir Safarpoor, Shivam Kalra, Danial Maleki, Abtin Riasatian, Morteza Babaie
    The American Journal of Pathology.2021; 191(10): 1702.     CrossRef
  • Automated Classification and Segmentation in Colorectal Images Based on Self-Paced Transfer Network
    Yao Yao, Shuiping Gou, Ru Tian, Xiangrong Zhang, Shuixiang He, Zhiguo Zhou
    BioMed Research International.2021; 2021: 1.     CrossRef
  • Artificial intelligence and sleep: Advancing sleep medicine
    Nathaniel F. Watson, Christopher R. Fernandez
    Sleep Medicine Reviews.2021; 59: 101512.     CrossRef
  • Prospective Of Artificial Intelligence: Emerging Trends In Modern Biosciences Research
    Pradeep Kumar, Ajit Kumar Singh Yadav, Abhishek Singh
    IOP Conference Series: Materials Science and Engineering.2021; 1020(1): 012008.     CrossRef
  • Use and Control of Artificial Intelligence in Patients Across the Medical Workflow: Single-Center Questionnaire Study of Patient Perspectives
    Simon Lennartz, Thomas Dratsch, David Zopfs, Thorsten Persigehl, David Maintz, Nils Große Hokamp, Daniel Pinto dos Santos
    Journal of Medical Internet Research.2021; 23(2): e24221.     CrossRef
  • HEAL: an automated deep learning framework for cancer histopathology image analysis
    Yanan Wang, Nicolas Coudray, Yun Zhao, Fuyi Li, Changyuan Hu, Yao-Zhong Zhang, Seiya Imoto, Aristotelis Tsirigos, Geoffrey I Webb, Roger J Daly, Jiangning Song, Zhiyong Lu
    Bioinformatics.2021; 37(22): 4291.     CrossRef
  • A Review of Applications of Artificial Intelligence in Gastroenterology
    Khalid Nawab, Ravi Athwani, Awais Naeem, Muhammad Hamayun, Momna Wazir
    Cureus.2021;[Epub]     CrossRef
  • Evaluating Cancer-Related Biomarkers Based on Pathological Images: A Systematic Review
    Xiaoliang Xie, Xulin Wang, Yuebin Liang, Jingya Yang, Yan Wu, Li Li, Xin Sun, Pingping Bing, Binsheng He, Geng Tian, Xiaoli Shi
    Frontiers in Oncology.2021;[Epub]     CrossRef
  • Deep learning-based histopathological segmentation for whole slide images of colorectal cancer in a compressed domain
    Hyeongsub Kim, Hongjoon Yoon, Nishant Thakur, Gyoyeon Hwang, Eun Jung Lee, Chulhong Kim, Yosep Chong
    Scientific Reports.2021;[Epub]     CrossRef
  • Deep Learning on Oral Squamous Cell Carcinoma Ex Vivo Fluorescent Confocal Microscopy Data: A Feasibility Study
    Veronika Shavlokhova, Sameena Sandhu, Christa Flechtenmacher, Istvan Koveshazi, Florian Neumeier, Víctor Padrón-Laso, Žan Jonke, Babak Saravi, Michael Vollmer, Andreas Vollmer, Jürgen Hoffmann, Michael Engel, Oliver Ristow, Christian Freudlsperger
    Journal of Clinical Medicine.2021; 10(22): 5326.     CrossRef
  • A Pathologist-Annotated Dataset for Validating Artificial Intelligence: A Project Description and Pilot Study
    Sarah N. Dudgeon, Si Wen, Matthew G. Hanna, Rajarsi Gupta, Mohamed Amgad, Manasi Sheth, Hetal Marble, Richard Huang, Markus D. Herrmann, Clifford H. Szu, Darick Tong, Bruce Werness, Evan Szu, Denis Larsimont, Anant Madabhushi, Evangelos Hytopoulos, Weijie
    Journal of Pathology Informatics.2021; 12(1): 45.     CrossRef
  • Artificial Intelligence in Medicine: A Multinational Multi-Center Survey on the Medical and Dental Students' Perception
    Sotirios Bisdas, Constantin-Cristian Topriceanu, Zosia Zakrzewska, Alexandra-Valentina Irimia, Loizos Shakallis, Jithu Subhash, Maria-Madalina Casapu, Jose Leon-Rojas, Daniel Pinto dos Santos, Dilys Miriam Andrews, Claudia Zeicu, Ahmad Mohammad Bouhuwaish
    Frontiers in Public Health.2021;[Epub]     CrossRef
  • Digital/Computational Technology for Molecular Cytology Testing: A Short Technical Note with Literature Review
    Robert Y. Osamura, Naruaki Matsui, Masato Kawashima, Hiroyasu Saiga, Maki Ogura, Tomoharu Kiyuna
    Acta Cytologica.2021; 65(4): 342.     CrossRef
  • Advances in Digital Pathology: From Artificial Intelligence to Label-Free Imaging
    Frederik Großerueschkamp, Hendrik Jütte, Klaus Gerwert, Andrea Tannapfel
    Visceral Medicine.2021; 37(6): 482.     CrossRef
  • Feasibility of fully automated classification of whole slide images based on deep learning
    Kyung-Ok Cho, Sung Hak Lee, Hyun-Jong Jang
    The Korean Journal of Physiology & Pharmacology.2020; 24(1): 89.     CrossRef
  • Same same but different: A Web‐based deep learning application revealed classifying features for the histopathologic distinction of cortical malformations
    Joshua Kubach, Angelika Muhlebner‐Fahrngruber, Figen Soylemezoglu, Hajime Miyata, Pitt Niehusmann, Mrinalini Honavar, Fabio Rogerio, Se‐Hoon Kim, Eleonora Aronica, Rita Garbelli, Samuel Vilz, Alexander Popp, Stefan Walcher, Christoph Neuner, Michael Schol
    Epilepsia.2020; 61(3): 421.     CrossRef
  • Segmentation and Classification in Digital Pathology for Glioma Research: Challenges and Deep Learning Approaches
    Tahsin Kurc, Spyridon Bakas, Xuhua Ren, Aditya Bagari, Alexandre Momeni, Yue Huang, Lichi Zhang, Ashish Kumar, Marc Thibault, Qi Qi, Qian Wang, Avinash Kori, Olivier Gevaert, Yunlong Zhang, Dinggang Shen, Mahendra Khened, Xinghao Ding, Ganapathy Krishnamu
    Frontiers in Neuroscience.2020;[Epub]     CrossRef
  • Artificial intelligence as the next step towards precision pathology
    B. Acs, M. Rantalainen, J. Hartman
    Journal of Internal Medicine.2020; 288(1): 62.     CrossRef
  • Introduction to digital pathology and computer-aided pathology
    Soojeong Nam, Yosep Chong, Chan Kwon Jung, Tae-Yeong Kwak, Ji Youl Lee, Jihwan Park, Mi Jung Rho, Heounjeong Go
    Journal of Pathology and Translational Medicine.2020; 54(2): 125.     CrossRef
  • Artificial intelligence with multi-functional machine learning platform development for better healthcare and precision medicine
    Zeeshan Ahmed, Khalid Mohamed, Saman Zeeshan, XinQi Dong
    Database.2020;[Epub]     CrossRef
  • Scoring pleurisy in slaughtered pigs using convolutional neural networks
    Abigail R. Trachtman, Luca Bergamini, Andrea Palazzi, Angelo Porrello, Andrea Capobianco Dondona, Ercole Del Negro, Andrea Paolini, Giorgio Vignola, Simone Calderara, Giuseppe Marruchella
    Veterinary Research.2020;[Epub]     CrossRef
  • Current Status of Computational Intelligence Applications in Dermatological Clinical Practice
    Carmen Rodríguez-Cerdeira, José Luís González-Cespón, Roberto Arenas
    The Open Dermatology Journal.2020; 14(1): 6.     CrossRef
  • New unified insights on deep learning in radiological and pathological images: Beyond quantitative performances to qualitative interpretation
    Yoichi Hayashi
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  • Artificial Intelligence in Cardiology: Present and Future
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  • Artificial intelligence in oncology
    Hideyuki Shimizu, Keiichi I. Nakayama
    Cancer Science.2020; 111(5): 1452.     CrossRef
  • Artificial intelligence and the future of global health
    Nina Schwalbe, Brian Wahl
    The Lancet.2020; 395(10236): 1579.     CrossRef
  • The future of pathology is digital
    J.D. Pallua, A. Brunner, B. Zelger, M. Schirmer, J. Haybaeck
    Pathology - Research and Practice.2020; 216(9): 153040.     CrossRef
  • Weakly-supervised learning for lung carcinoma classification using deep learning
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    Scientific Reports.2020;[Epub]     CrossRef
  • The use of artificial intelligence, machine learning and deep learning in oncologic histopathology
    Ahmed S. Sultan, Mohamed A. Elgharib, Tiffany Tavares, Maryam Jessri, John R. Basile
    Journal of Oral Pathology & Medicine.2020; 49(9): 849.     CrossRef
  • Convergence of Digital Pathology and Artificial Intelligence Tools in Anatomic Pathology Practice: Current Landscape and Future Directions
    Anil V. Parwani, Mahul B. Amin
    Advances in Anatomic Pathology.2020; 27(4): 221.     CrossRef
  • Advances in tissue-based imaging: impact on oncology research and clinical practice
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    Expert Review of Molecular Diagnostics.2020; 20(10): 1027.     CrossRef
  • Current Trends of Artificial Intelligence for Colorectal Cancer Pathology Image Analysis: A Systematic Review
    Nishant Thakur, Hongjun Yoon, Yosep Chong
    Cancers.2020; 12(7): 1884.     CrossRef
  • Explainable Machine Learning Model for Predicting GI Bleed Mortality in the Intensive Care Unit
    Farah Deshmukh, Shamel S. Merchant
    American Journal of Gastroenterology.2020; 115(10): 1657.     CrossRef
  • Prediction of clinically actionable genetic alterations from colorectal cancer histopathology images using deep learning
    Hyun-Jong Jang, Ahwon Lee, J Kang, In Hye Song, Sung Hak Lee
    World Journal of Gastroenterology.2020; 26(40): 6207.     CrossRef
  • Application of system analysis methods for modeling the development of hand-arm vibration syndrome: problems and approaches to solution
    M P Diakovich, M V Krivov
    Journal of Physics: Conference Series.2020; 1661(1): 012029.     CrossRef
  • Histo-ELISA technique for quantification and localization of tissue components
    Zhongmin Li, Silvia Goebel, Andreas Reimann, Martin Ungerer
    Scientific Reports.2020;[Epub]     CrossRef
  • Role of artificial intelligence in diagnostic oral pathology-A modern approach
    AyinampudiBhargavi Krishna, Azra Tanveer, PanchaVenkat Bhagirath, Ashalata Gannepalli
    Journal of Oral and Maxillofacial Pathology.2020; 24(1): 152.     CrossRef
  • Applications of deep learning for the analysis of medical data
    Hyun-Jong Jang, Kyung-Ok Cho
    Archives of Pharmacal Research.2019; 42(6): 492.     CrossRef
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    Applied Sciences.2019; 9(15): 2982.     CrossRef
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    Christopher J. Kelly, Alan Karthikesalingam, Mustafa Suleyman, Greg Corrado, Dominic King
    BMC Medicine.2019;[Epub]     CrossRef
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    Neofytos Dimitriou, Ognjen Arandjelović, Peter D. Caie
    Frontiers in Medicine.2019;[Epub]     CrossRef
  • Barriers to Artificial Intelligence Adoption in Healthcare Management: A Systematic Review
    Mir Mohammed Assadullah
    SSRN Electronic Journal .2019;[Epub]     CrossRef
HER2 status in breast cancer: changes in guidelines and complicating factors for interpretation
Soomin Ahn, Ji Won Woo, Kyoungyul Lee, So Yeon Park
J Pathol Transl Med. 2020;54(1):34-44.   Published online November 6, 2019
DOI: https://doi.org/10.4132/jptm.2019.11.03
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AbstractAbstract PDF
Human epidermal growth factor receptor 2 (HER2) protein overexpression and/or HER2 gene amplification is found in about 20% of invasive breast cancers. It is a sole predictive marker for treatment benefits from HER2 targeted therapy and thus, HER2 testing is a routine practice for newly diagnosed breast cancer in pathology. Currently, HER2 immunohistochemistry (IHC) is used for a screening test, and in situ hybridization is used as a confirmation test for HER2 IHC equivocal cases. Since the American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) guidelines on HER2 testing was first released in 2007, it has been updated to provide clear instructions for HER2 testing and accurate determination of HER2 status in breast cancer. During HER2 interpretation, some pitfalls such as intratumoral HER2 heterogeneity and increase in chromosome enumeration probe 17 signals may lead to inaccurate assessment of HER2 status. Moreover, HER2 status can be altered after neoadjuvant chemotherapy or during metastatic progression, due to biologic or methodologic issues. This review addresses recent updates of ASCO/CAP guidelines and factors complicating in the interpretation of HER2 status in breast cancers.

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  • Standardized pathology report for HER2 testing in compliance with 2023 ASCO/CAP updates and 2023 ESMO consensus statements on HER2-low breast cancer
    Mariia Ivanova, Francesca Maria Porta, Marianna D’Ercole, Carlo Pescia, Elham Sajjadi, Giulia Cursano, Elisa De Camilli, Oriana Pala, Giovanni Mazzarol, Konstantinos Venetis, Elena Guerini-Rocco, Giuseppe Curigliano, Giuseppe Viale, Nicola Fusco
    Virchows Archiv.2024; 484(1): 3.     CrossRef
  • Analytical Performance Evaluation of a 523-Gene Circulating Tumor DNA Assay for Next-Generation Sequencing–Based Comprehensive Tumor Profiling in Liquid Biopsy Samples
    Johannes Harter, Eleonora Buth, Janina Johaenning, Florian Battke, Maria Kopp, Henning Zelba, Martin Schulze, Jiri Koedding, Saskia Biskup
    The Journal of Molecular Diagnostics.2024; 26(1): 61.     CrossRef
  • Are There More HER2 FISH in the Sea? An Institution’s Experience in Identifying HER2 Positivity Using Fluorescent In Situ Hybridization in Patients with HER2 Negative Immunohistochemistry
    Camille Suydam, Fairouz Chibane, Nicole Brown, Madeleine Schlafly, Alicia H. Arnold, Intisar Ghleilib, Melissa Easley, Joseph White
    Annals of Surgical Oncology.2024; 31(1): 376.     CrossRef
  • Impact of HER2-low status for patients with early-stage breast cancer and non-pCR after neoadjuvant chemotherapy: a National Cancer Database Analysis
    Huiyue Li, Jennifer K. Plichta, Kan Li, Yizi Jin, Samantha M. Thomas, Fei Ma, Li Tang, Qingyi Wei, You-Wen He, Qichen Chen, Yuanyuan Guo, Yueping Liu, Jian Zhang, Sheng Luo
    Breast Cancer Research and Treatment.2024; 204(1): 89.     CrossRef
  • Qualification of a multiplexed tissue imaging assay and detection of novel patterns of HER2 heterogeneity in breast cancer
    Jennifer L. Guerriero, Jia-Ren Lin, Ricardo G. Pastorello, Ziming Du, Yu-An Chen, Madeline G. Townsend, Kenichi Shimada, Melissa E. Hughes, Siyang Ren, Nabihah Tayob, Kelly Zheng, Shaolin Mei, Alyssa Patterson, Krishan L. Taneja, Otto Metzger, Sara M. Tol
    npj Breast Cancer.2024;[Epub]     CrossRef
  • Clinical Utility and Benefits of Comprehensive Genomic Profiling in Cancer
    Melissa Yuwono Tjota, Jeremy P Segal, Peng Wang
    The Journal of Applied Laboratory Medicine.2024; 9(1): 76.     CrossRef
  • High contrast breast cancer biomarker semi-quantification and immunohistochemistry imaging using upconverting nanoparticles
    Sanathana Konugolu Venkata Sekar, Hui Ma, Katarzyna Komolibus, Gokhan Dumlupinar, Matthias J. Mickert, Krzysztof Krawczyk, Stefan Andersson-Engels
    Biomedical Optics Express.2024; 15(2): 900.     CrossRef
  • HER2-low breast cancer and response to neoadjuvant chemotherapy: a population-based cohort study
    Ximena Baez-Navarro, Mieke R. van Bockstal, Agnes Jager, Carolien H.M. van Deurzen
    Pathology.2024; 56(3): 334.     CrossRef
  • Fast-tracking drug development with biomarkers and companion diagnostics
    Noreen McBrearty, Devika Bahal, Suso Platero
    Journal of Cancer Metastasis and Treatment.2024;[Epub]     CrossRef
  • Emerging Landscape of Targeted Therapy of Breast Cancers With Low Human Epidermal Growth Factor Receptor 2 Protein Expression
    Gary Tozbikian, Savitri Krishnamurthy, Marilyn M. Bui, Michael Feldman, David G. Hicks, Shabnam Jaffer, Thaer Khoury, Shi Wei, Hannah Wen, Paula Pohlmann
    Archives of Pathology & Laboratory Medicine.2024; 148(2): 242.     CrossRef
  • Treatment Patterns and Health Outcomes among Patients with HER2 IHC0/-Low Metastatic or Recurrent Breast Cancer
    Eliya Farah, Chantelle Carbonell, Devon J. Boyne, Darren R. Brenner, Jan-Willem Henning, Daniel Moldaver, Simran Shokar, Winson Y. Cheung
    Cancers.2024; 16(3): 518.     CrossRef
  • Clinical Internal Dosimetry and Biodistribution of 177Lu-DOTA-Trastuzumab in HER2-Positive Metastatic and Locally Advanced Breast Carcinoma
    Yoga S. Narwadkar, Rahul V. Parghane, Sudeep Sahu, Sangita Lad, Kamal Deep, Gaurav Wanage, Tejal Suralkar, Sharmila Banerjee, Sudeep Gupta, Sandip Basu, Rajendra A. Badwe
    Clinical Nuclear Medicine.2024; 49(4): e149.     CrossRef
  • Molecular Classifications in Gastric Cancer: A Call for Interdisciplinary Collaboration
    Cristina Díaz del Arco, María Jesús Fernández Aceñero, Luis Ortega Medina
    International Journal of Molecular Sciences.2024; 25(5): 2649.     CrossRef
  • The combined immunohistochemical expression of AMBRA1 and SQSTM1 identifies patients with poorly differentiated cutaneous squamous cell carcinoma at risk of metastasis: A proof of concept study
    Michael H. Alexander, William J. Cousins, Tom Ewen, Andrew P. South, Penny Lovat, Niki Stefanos
    Journal of Cutaneous Pathology.2024;[Epub]     CrossRef
  • Concordance between pathologists and between specimen types in detection of HER2-low breast carcinoma by immunohistochemistry
    Jing Wang, Esther Yoon, Savitri Krishnamurthy
    Annals of Diagnostic Pathology.2024; 70: 152288.     CrossRef
  • Detection of HER2 expression using 99mTc-NM-02 nanobody in patients with breast cancer: a non-randomized, non-blinded clinical trial
    Lingzhou Zhao, Yan Xing, Changcun Liu, Shaofei Ma, Wenhua Huang, Zhen Cheng, Jinhua Zhao
    Breast Cancer Research.2024;[Epub]     CrossRef
  • Pyrotinib and Trastuzumab Plus Chemotherapy Serve as an Acceptable Neoadjuvant Regimen Exhibiting Good Efficacy and Tolerance in HER2-Positive Breast Cancer Patients
    Yibo Chen, Tianyi Zhang, Rui Zhang, Xuchen Cao
    Cancer Biotherapy and Radiopharmaceuticals.2024;[Epub]     CrossRef
  • Clinicopathological and prognostic significance of VEGF, PDGF-B, and HER2/neu expression in gallbladder cancer
    Pooja Shukla, Kumudesh Mishra, Ratnakar Shukla, Ruchira Vishwakarma, Niraj Kumari, Narendra Krishnani, Anu Behari, Vinay K. Kapoor
    Journal of Cancer Research and Therapeutics.2024; 20(1): 349.     CrossRef
  • Open questions, current challenges, and future perspectives in targeting human epidermal growth factor receptor 2-low breast cancer
    G. Curigliano, R. Dent, H. Earle, S. Modi, P. Tarantino, G. Viale, S.M. Tolaney
    ESMO Open.2024; 9(4): 102989.     CrossRef
  • Concordance of HER2 status between core needle biopsy and surgical resection specimens of breast cancer: an analysis focusing on the HER2-low status
    Sei Na, Milim Kim, Yujun Park, Hyun Jung Kwon, Hee-Chul Shin, Eun-Kyu Kim, Mijung Jang, Sun Mi Kim, So Yeon Park
    Breast Cancer.2024;[Epub]     CrossRef
  • Surgical Management of the Axilla in HR+/HER2– Breast Cancer in the Z1071 Era: A Propensity Score-Matched Analysis of the National Cancer Database
    Vayda R. Barker, Samer A. Naffouje, Melissa A. Mallory, Susan A. Hoover, Christine Laronga
    Annals of Surgical Oncology.2023; 30(13): 8371.     CrossRef
  • Noninvasive identification of HER2-low-positive status by MRI-based deep learning radiomics predicts the disease-free survival of patients with breast cancer
    Yuan Guo, Xiaotong Xie, Wenjie Tang, Siyi Chen, Mingyu Wang, Yaheng Fan, Chuxuan Lin, Wenke Hu, Jing Yang, Jialin Xiang, Kuiming Jiang, Xinhua Wei, Bingsheng Huang, Xinqing Jiang
    European Radiology.2023; 34(2): 899.     CrossRef
  • Systemic investigation of inetetamab in combination with small molecules to treat HER2-overexpressing breast and gastric cancers
    Lan Deng, Le Zhao, Lifen Liu, Haomin Huang
    Open Life Sciences.2023;[Epub]     CrossRef
  • HER2-low expression in patients with advanced or metastatic solid tumors
    B. Uzunparmak, C. Haymaker, G. Raso, S. Masciari, L. Wang, H. Lin, A. Gorur, B. Kirby, A.-M. Cimo, A. Kennon, Q. Ding, G. Urschel, Y. Yuan, G. Feng, Y. Rizvi, A. Hussain, C. Zhu, P. Kim, G. Abbadessa, V. Subbiah, T.A. Yap, J. Rodon, S.A. Piha-Paul, F. Mer
    Annals of Oncology.2023; 34(11): 1035.     CrossRef
  • Data on 2D culture characterisation of potential markers in human HER2-positive breast cancer cell lines
    Son H. Pham, Lyn R. Griffiths, Rachel K. Okolicsanyi, Larisa M. Haupt
    Data in Brief.2023; 46: 108880.     CrossRef
  • Determining HER2 Status by Artificial Intelligence: An Investigation of Primary, Metastatic, and HER2 Low Breast Tumors
    Christiane Palm, Catherine E. Connolly, Regina Masser, Barbara Padberg Sgier, Eva Karamitopoulou, Quentin Simon, Beata Bode, Marianne Tinguely
    Diagnostics.2023; 13(1): 168.     CrossRef
  • Gene amplification mutations originate prior to selective stress in Acinetobacter baylyi
    Jennifer A Herrmann, Agata Koprowska, Tesa J Winters, Nancy Villanueva, Victoria D Nikityuk, Feini Pek, Elizabeth M Reis, Constancia Z Dominguez, Daniel Davis, Eric McPherson, Staci R Rocco, Cynthia Recendez, Shyla M Difuntorum, Kelly Faeth, Mario D Lopez
    G3.2023;[Epub]     CrossRef
  • Flow Rate-Independent Multiscale Liquid Biopsy for Precision Oncology
    Jie Wang, Robert Dallmann, Renquan Lu, Jing Yan, Jérôme Charmet
    ACS Sensors.2023; 8(3): 1200.     CrossRef
  • Single-cell HER2 quantification via instant signal amplification in microdroplets
    Xiaoxian Liu, Yifan Zhu, Caoxin Li, Yanyun Fang, Jinna Chen, Fei Xu, Yanqing Lu, Perry Ping Shum, Ying Liu, Guanghui Wang
    Analytica Chimica Acta.2023; 1251: 340976.     CrossRef
  • Molecular imaging of HER2 receptor: Targeting HER2 for imaging and therapy in nuclear medicine
    Daniela Miladinova
    Frontiers in Molecular Biosciences.2023;[Epub]     CrossRef
  • CORRELATION BETWEEN DIFFERENT CLINICOPATHOLOGICAL PARAMETERS AND MOLECULAR SUBTYPES OF FEMALE BREAST CARCINOMA IN SOUTH REGION OF IRAQ
    Yassir Alaa Muhammed Hassan Shubbar
    Wiadomości Lekarskie.2023; 76(1): 97.     CrossRef
  • Pathological identification of HER2-low breast cancer: Tips, tricks, and troubleshooting for the optimal test
    Elham Sajjadi, Elena Guerini-Rocco, Elisa De Camilli, Oriana Pala, Giovanni Mazzarol, Konstantinos Venetis, Mariia Ivanova, Nicola Fusco
    Frontiers in Molecular Biosciences.2023;[Epub]     CrossRef
  • Protective Effect of HER2 Gene Polymorphism rs24537331 in the Outcome of Canine Mammary Tumors
    Ana Canadas-Sousa, Marta Santos, Patrícia Dias-Pereira
    Animals.2023; 13(8): 1384.     CrossRef
  • Can Patients with HER2-Low Breast Cancer Benefit from Anti-HER2 Therapies? A Review
    Jin Wang, Dongying Liao, Xuemin Zhang, Changhong Miao, Kuang Chen
    Breast Cancer: Targets and Therapy.2023; Volume 15: 281.     CrossRef
  • HER2 Low Breast Cancer: A New Subtype or a Trojan for Cytotoxic Drug Delivery?
    Marina Popović, Tajana Silovski, Marija Križić, Natalija Dedić Plavetić
    International Journal of Molecular Sciences.2023; 24(9): 8206.     CrossRef
  • HER2-Low Breast Cancer—Diagnostic Challenges and Opportunities for Insights from Ongoing Studies: A Podcast
    Aditya Bardia, Giuseppe Viale
    Targeted Oncology.2023; 18(3): 313.     CrossRef
  • Histopathological and immunohistochemical analysis of predictive and prognostic markers in spontaneous canine mammary cancer
    Vladimír Tancoš, Marcel Kovalik, Martin Levkut, Martina Bobrovská, Petra Kolenčíková, Ľubomír Straka, Zuzana Ševčíková, Ondřej Škor, Martina Antošová, Lukáš Plank, Keith L. Thoday
    Acta Veterinaria Brno.2023; 92(2): 143.     CrossRef
  • Dissecting sources of variability in patient response to targeted therapy: anti-HER2 therapies as a case study
    Timothy Qi, Yanguang Cao
    European Journal of Pharmaceutical Sciences.2023; 186: 106467.     CrossRef
  • The Effect of HER2-Low Status on Pathological Complete Response and Survival in Triple-Negative Breast Cancer: A Systemic Review and Meta-Analysis
    Yakup Ergun, Baran Akagunduz, Cengiz Karacin, Sema Turker, Gokhan Ucar
    Clinical Breast Cancer.2023; 23(6): 567.     CrossRef
  • Efficacy, toxicity and prognostic factors of pyrotinib‑involved neoadjuvant therapy in HER2‑positive breast cancer: A retrospective study
    Hao Wang, Hailing Cao, Zhiyun Guo
    Oncology Letters.2023;[Epub]     CrossRef
  • Identification of novel chemical scaffolds against kinase domain of cancer causing human epidermal growth factor receptor 2: a systemic chemoinformatic approach
    Faris Alrumaihi
    Journal of Biomolecular Structure and Dynamics.2023; : 1.     CrossRef
  • Advancements in clinical aspects of targeted therapy and immunotherapy in breast cancer
    Feng Ye, Saikat Dewanjee, Yuehua Li, Niraj Kumar Jha, Zhe-Sheng Chen, Ankush Kumar, Vishakha, Tapan Behl, Saurabh Kumar Jha, Hailin Tang
    Molecular Cancer.2023;[Epub]     CrossRef
  • Weakly supervised bilayer convolutional network in segmentation of HER2 related cells to guide HER2 targeted therapies
    Ching-Wei Wang, Kun-Lin Lin, Hikam Muzakky, Yi-Jia Lin, Tai-Kuang Chao
    Computerized Medical Imaging and Graphics.2023; 108: 102270.     CrossRef
  • Immune Biomarkers in Triple-Negative Breast Cancer: Improving the Predictivity of Current Testing Methods
    Francesca Maria Porta, Elham Sajjadi, Konstantinos Venetis, Chiara Frascarelli, Giulia Cursano, Elena Guerini-Rocco, Nicola Fusco, Mariia Ivanova
    Journal of Personalized Medicine.2023; 13(7): 1176.     CrossRef
  • HER2 Equivocal (Score = 2+) Breast Carcinoma Cases Identified by Immunohistochemistry at a South African Hospital. What is the Impact of Fluorescent In Situ Hybridization Testing?
    Reena Dhansukh Mohanlal, Nikki Bouwer, Pascale Willem
    Applied Immunohistochemistry & Molecular Morphology.2023; 31(8): 555.     CrossRef
  • Discordance of HER2 Expression and/or Amplification on Repeat Testing
    Timothy P. DiPeri, Kathleen Kong, Kaushik Varadarajan, Daniel D. Karp, Jaffer A. Ajani, Shubham Pant, Michael F. Press, Sarina A. Piha-Paul, Ecaterina E. Dumbrava, Funda Meric-Bernstam
    Molecular Cancer Therapeutics.2023; 22(8): 976.     CrossRef
  • Low and Ultra-Low HER2 in Human Breast Cancer: An Effort to Define New Neoplastic Subtypes
    Mariausilia Franchina, Cristina Pizzimenti, Vincenzo Fiorentino, Maurizio Martini, Giuseppina Rosaria Rita Ricciardi, Nicola Silvestris, Antonio Ieni, Giovanni Tuccari
    International Journal of Molecular Sciences.2023; 24(16): 12795.     CrossRef
  • Genetic analysis of oligo-recurrence breast cancer: correlation with clinical outcomes
    Kuikui Jiang, Danyang Zhou, Fei Xu, Wen Xia, Qiufan Zheng, Qianyi Lu, Rongzhen Luo, Ruoxi Hong, Shusen Wang
    BMC Cancer.2023;[Epub]     CrossRef
  • Single domain antibodies specific for HER2 dimerization domain effectively disrupts HER2 dimerization
    Ahmad Najafi, Reza Valadan, Hossein Asgarian-Omran, Alireza Rafiei, Mohsen Tehrani
    International Immunopharmacology.2023; 124: 110999.     CrossRef
  • Récepteur du facteur de croissance épidermique HER2, tests utilisés pour rechercher son amplification dans le cancer du sein : principes et limites
    Imane Eliahiai, Mohammed Eljiar, Sanae Chaib, Jinane KHarmoum, Mariame Chraïbi
    Bulletin du Cancer.2023; 110(12): 1301.     CrossRef
  • HER2 copy number determination in breast cancer using the highly sensitive droplet digital PCR method
    Beate Alinger-Scharinger, Cornelia Kronberger, Georg Hutarew, Wolfgang Hitzl, Roland Reitsamer, Klaassen-Federspiel Frederike, Martina Hager, Thorsten Fischer, Karl Sotlar, Heidi Jaksch-Bogensperger
    Virchows Archiv.2023;[Epub]     CrossRef
  • Integrated Molecular Characterization of HER2-Low Breast Cancer Using Next Generation Sequencing (NGS)
    Jean-Louis Merlin, Marie Husson, Nassim Sahki, Pauline Gilson, Vincent Massard, Alexandre Harlé, Agnès Leroux
    Biomedicines.2023; 11(12): 3164.     CrossRef
  • Design of a Ratiometric Plasmonic Biosensor for Herceptin Detection in HER2-Positive Breast Cancer
    Neda Shahbazi, Rouholah Zare-Dorabei, Seyed Morteza Naghib
    ACS Biomaterials Science & Engineering.2022; 8(2): 871.     CrossRef
  • A highly sensitive nanobiosensor based on aptamer-conjugated graphene-decorated rhodium nanoparticles for detection of HER2-positive circulating tumor cells
    Mahdi Sadeghi, Soheila Kashanian, Seyed Morteza Naghib, Esfandyar Askari, Fateme Haghiralsadat, Davood Tofighi
    Nanotechnology Reviews.2022; 11(1): 793.     CrossRef
  • Anti-HER2 therapy in metastatic breast cancer: many choices and future directions
    Carrie S. Wynn, Shou-Ching Tang
    Cancer and Metastasis Reviews.2022; 41(1): 193.     CrossRef
  • Electroanalytical overview: screen-printed electrochemical sensing platforms for the detection of vital cardiac, cancer and inflammatory biomarkers
    Robert D. Crapnell, Alejandro Garcia-Miranda Ferrari, Nina C. Dempsey, Craig E. Banks
    Sensors & Diagnostics.2022; 1(3): 405.     CrossRef
  • FTO genotype was associated with breast cancer in HER2 negative patients
    Fateme Montazeri, Hossein Hatami, Soroor Fathi, Naeemeh Hasanpour Ardekanizadeh, Fatemeh Bourbour, Samira Rastgoo, Fatemeh Shafiee, Mohammad Esmail Akbari, Maryam Gholamalizadeh, Seyed Alireza Mosavi Jarrahi, Saeid Doaei
    Clinical Nutrition ESPEN.2022; 49: 495.     CrossRef
  • Breast Cancer Human Epidermal Growth Factor Receptor 2 mRNA Molecular Testing Compared to Immunohistochemistry with Correlation to Neoadjuvant Therapy Response
    Mahmoud Behairy, Samia Mohamed Gabal, Mohamed Sherif Negm
    Open Access Macedonian Journal of Medical Sciences.2022; 10(A): 352.     CrossRef
  • Validity and utility of HER2/ERBB2 copy number variation assessed in liquid biopsies from breast cancer patients: A systematic review
    Noortje Verschoor, Teoman Deger, Agnes Jager, Stefan Sleijfer, Saskia M. Wilting, John W.M. Martens
    Cancer Treatment Reviews.2022; 106: 102384.     CrossRef
  • RETRACTED: Longitude Variation of the microRNA-497/FGF-23 Axis during Treatment and Its Linkage with Neoadjuvant/Adjuvant Trastuzumab-Induced Cardiotoxicity in HER2-Positive Breast Cancer Patients
    Hui Liu, Xiaoyan Hu, Lingyun Wang, Tao Du, Jing Feng, Ming Li, Lei Liu, Xiaofang Liu
    Frontiers in Surgery.2022;[Epub]     CrossRef
  • Use of Radionuclide-Based Imaging Methods in Breast Cancer
    Betül Altunay, Agnieszka Morgenroth, Felix M. Mottaghy
    Seminars in Nuclear Medicine.2022; 52(5): 561.     CrossRef
  • Functional regulations between genetic alteration-driven genes and drug target genes acting as prognostic biomarkers in breast cancer
    Li Wang, Lei Yu, Jian Shi, Feng Li, Caiyu Zhang, Haotian Xu, Xiangzhe Yin, Lixia Wang, Shihua Lin, Anastasiia Litvinova, Yanyan Ping, Shangwei Ning, Hongying Zhao
    Scientific Reports.2022;[Epub]     CrossRef
  • Human epidermal growth factor receptor-2 and endocrine resistance in hormone-dependent breast cancer
    Anastasia Alataki, Mitch Dowsett
    Endocrine-Related Cancer.2022; 29(8): R105.     CrossRef
  • The Evolution of Targeted Radionuclide Diagnosis of HER2-Positive Breast Cancer
    Olga D. Bragina, Sergei M. Deyev, Vladimir I. Chernov, Vladimir M. Tolmachev
    Acta Naturae.2022; 14(2): 4.     CrossRef
  • Deriving tumor purity from cancer next generation sequencing data: applications for quantitative ERBB2 (HER2) copy number analysis and germline inference of BRCA1 and BRCA2 mutations
    Stephanie E. Siegmund, Danielle K. Manning, Phani K. Davineni, Fei Dong
    Modern Pathology.2022; 35(10): 1458.     CrossRef
  • Current challenges and unmet needs in treating patients with human epidermal growth factor receptor 2-positive advanced breast cancer
    Matti Aapro, Fatima Cardoso, Giuseppe Curigliano, Alexandru Eniu, Joseph Gligorov, Nadia Harbeck, Andreas Mueller, Olivia Pagani, Shani Paluch-Shimon, Elzbieta Senkus, Beat Thürlimann, Khalil Zaman
    The Breast.2022; 66: 145.     CrossRef
  • Application of Fluorescence In Situ Hybridization Assisted by Fluorescence Microscope in Detection of Her2 Gene in Breast Cancer Patients
    Fang Lu, Tingting Zhou, Yan Liu, Liying Song, Bin Zhang, Yuyan Li, Sorayouth Chumnanvej
    Contrast Media & Molecular Imaging.2022; 2022: 1.     CrossRef
  • High sensitivity label-free detection of HER2 using an Al–GaN/GaN high electron mobility transistor-based biosensor
    Shivanshu Mishra, Pharyanshu Kachhawa, Amber Kumar Jain, Rajiv Ranjan Thakur, Nidhi Chaturvedi
    Lab on a Chip.2022; 22(21): 4129.     CrossRef
  • Indian Data on HER2 Fluorescence In Situ Hybridization in Invasive Breast Cancer with Immunohistochemically Equivocal Results As Per 2018 ASCO/CAP Guidelines
    B. R. Nagarjun, Biren Parikh, Manaswi Nareshkumar Patel, Pina J. Trivedi, Dharmesh M. Patel
    South Asian Journal of Cancer.2022; 11(04): 281.     CrossRef
  • S‑phase fraction, lymph node status and disease staging as the main prognostic factors to differentiate between young and older patients with invasive breast carcinoma
    António Pinto, João Matos, Teresa Pereira, Giovani Silva, Saudade André
    Oncology Letters.2022;[Epub]     CrossRef
  • Inferring tumor-specific cancer dependencies through integrating ex vivo drug response assays and drug-protein profiling
    Alina Batzilla, Junyan Lu, Jarno Kivioja, Kerstin Putzker, Joe Lewis, Thorsten Zenz, Wolfgang Huber, James Gallo
    PLOS Computational Biology.2022; 18(8): e1010438.     CrossRef
  • Clinical possibilities of HER2-positive breast cancer diagnosis using alternative scaffold proteins
    O. D. Bragina, V. I. Chernov, S. M. Deyev, V. M. Tolmachev
    Bulletin of Siberian Medicine.2022; 21(3): 132.     CrossRef
  • Molecular Pathology of Gastric Cancer
    Moonsik Kim, An Na Seo
    Journal of Gastric Cancer.2022; 22(4): 264.     CrossRef
  • Loss of NECTIN1 triggers melanoma dissemination upon local IGF1 depletion
    Julien Ablain, Amira Al Mahi, Harriet Rothschild, Meera Prasad, Sophie Aires, Song Yang, Maxim E. Dokukin, Shuyun Xu, Michelle Dang, Igor Sokolov, Christine G. Lian, Leonard I. Zon
    Nature Genetics.2022; 54(12): 1839.     CrossRef
  • Advanced diagnosis technologies for HER2 breast cancer markers
    Mengxue Zhang
    Highlights in Science, Engineering and Technology.2022; 14: 44.     CrossRef
  • An Overview of Clinical Development of Agents for Metastatic or Advanced Breast Cancer Without ERBB2 Amplification (HER2-Low)
    Aleix Prat, Aditya Bardia, Giuseppe Curigliano, M. Elizabeth H. Hammond, Sibylle Loibl, Sara M. Tolaney, Giuseppe Viale
    JAMA Oncology.2022; 8(11): 1676.     CrossRef
  • Development of T-cell engagers selective for cells co-expressing two antigens
    Danielle M. Dicara, Sunil Bhakta, Mary Ann Go, James Ziai, Ron Firestein, Bill Forrest, Chen Gu, Steven R. Leong, Genee Lee, Shang-Fan Yu, Andrew G. Polson, Nicholas J. Agard
    mAbs.2022;[Epub]     CrossRef
  • The clinical significance of HER2 expression in DCIS
    Ioanna Akrida, Francesk Mulita
    Medical Oncology.2022;[Epub]     CrossRef
  • Antibody-Drug Conjugates in Breast Cancer: Spotlight on HER2
    Rachel Occhiogrosso Abelman, Arielle Medford, Laura Spring, Aditya Bardia
    The Cancer Journal.2022; 28(6): 423.     CrossRef
  • The Clinical Utility of Droplet Digital PCR for Profiling Circulating Tumor DNA in Breast Cancer Patients
    Ugur Gezer, Abel J. Bronkhorst, Stefan Holdenrieder
    Diagnostics.2022; 12(12): 3042.     CrossRef
  • Lapatinib and lapatinib plus trastuzumab therapy versus trastuzumab therapy for HER2 positive breast cancer patients: an updated systematic review and meta-analysis
    Ye Yuan, Xumei Liu, Yi Cai, Wenyuan Li
    Systematic Reviews.2022;[Epub]     CrossRef
  • Interactions dietary components with expression level of breast cancer-related genes
    Fatemeh Bourbour, Azam Pourtaheri, Khadijeh Abbasi, Naeemeh Hasanpour Ardekanizadeh, Maryam Gholamalizadeh, Azadeh Hajipour, Sepideh Abdollahi, Seyedeh Elaheh Bagheri, Mina Ahmadzadeh, Saeid Doaei, Arezoo Haghighian
    Egyptian Journal of Medical Human Genetics.2022;[Epub]     CrossRef
  • HER2-directed antibodies, affibodies and nanobodies as drug-delivery vehicles in breast cancer with a specific focus on radioimmunotherapy and radioimmunoimaging
    Betül Altunay, Agnieszka Morgenroth, Mohsen Beheshti, Andreas Vogg, Nicholas C. L. Wong, Hong Hoi Ting, Hans-Jürgen Biersack, Elmar Stickeler, Felix M. Mottaghy
    European Journal of Nuclear Medicine and Molecular Imaging.2021; 48(5): 1371.     CrossRef
  • Risk-based decision-making in the treatment of HER2-positive early breast cancer: Recommendations based on the current state of knowledge
    Christian Jackisch, Patricia Cortazar, Charles E. Geyer, Luca Gianni, Joseph Gligorov, Zuzana Machackova, Edith A. Perez, Andreas Schneeweiss, Sara M. Tolaney, Michael Untch, Andrew Wardley, Martine Piccart
    Cancer Treatment Reviews.2021; 99: 102229.     CrossRef
  • Histologic Patterns of Cutaneous Metastases of Breast Carcinoma: A Clinicopathologic Study of 232 Cases
    Shira Ronen, David Suster, Wei-Shen Chen, Natali Ronen, Sri Krishna C. Arudra, Celestine Trinidad, Doina Ivan, Victor G. Prieto, Saul Suster
    The American Journal of Dermatopathology.2021; 43(6): 401.     CrossRef
  • Standardized pathology report for breast cancer
    Soo Youn Cho, So Yeon Park, Young Kyung Bae, Jee Yeon Kim, Eun Kyung Kim, Woo Gyeong Kim, Youngmee Kwon, Ahwon Lee, Hee Jin Lee, Ji Shin Lee, Jee Young Park, Gyungyub Gong, Hye Kyoung Yoon
    Journal of Pathology and Translational Medicine.2021; 55(1): 1.     CrossRef
  • The impact of oral contraceptive use on breast cancer risk: State of the art and future perspectives in the era of 4P medicine
    R. Bonfiglio, M.L. Di Pietro
    Seminars in Cancer Biology.2021; 72: 11.     CrossRef
  • The Co-Expression of Melanoma-Antigen Family a Proteins and New York Esophageal Squamous Cell Carcinoma-1 in Breast Cancer: A Pilot Study
    Yu-Xin Wang, Feng-Lian Li, Li-Xin Du, Jun-Fang Liu, Li-Gang Huo, Shu-Qing Li, Bin Tian
    Cancer Management and Research.2021; Volume 13: 6123.     CrossRef
  • Targeting HER2 protein in individual cells using ICP-MS detection and its potential as prognostic and predictive breast cancer biomarker
    A. Fernández Asensio, M. Corte-Rodríguez, J. Bettmer, L.M. Sierra, M. Montes-Bayón, E. Blanco- González
    Talanta.2021; 235: 122773.     CrossRef
  • Development of a 99mTc-Labeled Single-Domain Antibody for SPECT/CT Assessment of HER2 Expression in Breast Cancer
    Lingzhou Zhao, Changcun Liu, Yan Xing, Jin He, Jim O’Doherty, Wenhua Huang, Jinhua Zhao
    Molecular Pharmaceutics.2021; 18(9): 3616.     CrossRef
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    Emad A. Rakha, Islam M. Miligy, Cecily M. Quinn, Elena Provenzano, Abeer M. Shaaban, Caterina Marchiò, Michael S. Toss, Grace Gallagy, Ciara Murray, Janice Walshe, Ayaka Katayama, Karim Eldib, Nahla Badr, Bruce Tanchel, Rebecca Millican-Slater, Colin Purd
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  • Loss of HER2‐positivity following neoadjuvant targeted therapy for breast cancer is not associated with inferior oncologic outcomes
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    Lun Li, Min Chen, Shuyue Zheng, Hanlu Li, Weiru Chi, Bingqiu Xiu, Qi Zhang, Jianjing Hou, Jia Wang, Jiong Wu
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    Yue Zhang, Zhao Bi, Xiaohan Dong, Miao Yu, Kangyu Wang, Xingguo Song, Li Xie, Xianrang Song
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Pathology Reporting of Thyroid Core Needle Biopsy: A Proposal of the Korean Endocrine Pathology Thyroid Core Needle Biopsy Study Group
Chan Kwon Jung, Hye Sook Min, Hyo Jin Park, Dong Eun Song, Jang Hee Kim, So Yeon Park, Hyunju Yoo, Mi Kyung Shin, Korean Endocrine Pathology Thyroid Core Needle Biopsy Study Group
J Pathol Transl Med. 2015;49(4):288-299.   Published online June 17, 2015
DOI: https://doi.org/10.4132/jptm.2015.06.04
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AbstractAbstract PDF
In recent years throughout Korea, the use of ultrasound-guided core needle biopsy (CNB) has become common for the preoperative diagnosis of thyroid nodules. However, there is no consensus on the pathology reporting system for thyroid CNB. The Korean Endocrine Pathology Thyroid Core Needle Biopsy Study Group held a conference on thyroid CNB pathology and developed guidelines through contributions from the participants. This article discusses the outcome of the discussions that led to a consensus on the pathology reporting of thyroid CNB.

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  • Follow-up of benign thyroid nodules confirmed by ultrasound-guided core needle biopsy after inconclusive cytology on fine-needle aspiration biopsy
    Yoon Ji Hwang, Hye Ryoung Koo, Jeong Seon Park
    Ultrasonography.2023; 42(1): 121.     CrossRef
  • Subcategorization of intermediate suspicion thyroid nodules based on suspicious ultrasonographic findings
    Haejung Kim, Jung Hee Shin, Ka Eun Kim, Myoung Kyoung Kim, Jiyun Oh, Soo Yeon Hahn
    Ultrasonography.2023; 42(2): 307.     CrossRef
  • Preoperative Risk Stratification of Follicular-patterned Thyroid Lesions on Core Needle Biopsy by Histologic Subtyping and RAS Variant-specific Immunohistochemistry
    Meejeong Kim, Sora Jeon, Chan Kwon Jung
    Endocrine Pathology.2023; 34(2): 247.     CrossRef
  • Cytological and Ultrasound Features of Thyroid Nodules Correlate With Histotypes and Variants of Thyroid Carcinoma
    Daniele Sgrò, Alessandro Brancatella, Giuseppe Greco, Liborio Torregrossa, Paolo Piaggi, Nicola Viola, Teresa Rago, Fulvio Basolo, Riccardo Giannini, Gabriele Materazzi, Rossella Elisei, Ferruccio Santini, Francesco Latrofa
    The Journal of Clinical Endocrinology & Metabolism.2023; 108(11): e1186.     CrossRef
  • Reevaluating diagnostic categories and associated malignancy risks in thyroid core needle biopsy
    Chan Kwon Jung
    Journal of Pathology and Translational Medicine.2023; 57(4): 208.     CrossRef
  • Contrast Enhancement Ultrasound Improves Diagnostic Accuracy for Thyroid Nodules: A Prospective Multicenter Study
    Jianming Li, Jianping Dou, Huarong Li, Fan Xiao, Jie Yu, Mingxing Xie, Ping Zhou, Lei Liang, Guiming Zhou, Ying Che, Cun Liu, Zhibin Cong, Fangyi Liu, Zhiyu Han, Ping Liang
    Journal of the Endocrine Society.2023;[Epub]     CrossRef
  • Core needle biopsy and ultrasonography are superior to fine needle aspiration in the management of follicular variant papillary thyroid carcinomas
    Ji-Ye Kim, Sunhee Chang, Ah-Young Kwon, Eun Young Park, Tae Hyuk Kim, Sangjoon Choi, Minju Lee, Young Lyun Oh
    Endocrine.2022; 75(2): 437.     CrossRef
  • Fine Needle Aspiration Cytology vs. Core Needle Biopsy for Thyroid Nodules: A Prospective, Experimental Study Using Surgical Specimen
    Hyuk Kwon, Jandee Lee, Soon Won Hong, Hyeong Ju Kwon, Jin Young Kwak, Jung Hyun Yoon
    Journal of the Korean Society of Radiology.2022; 83(3): 645.     CrossRef
  • Diagnostic efficacy, performance and safety of side-cut core needle biopsy for thyroid nodules: comparison of automated and semi-automated biopsy needles
    Ji Yeon Park, Seong Yoon Yi, Soo Heui Baek, Yu Hyun Lee, Heon-Ju Kwon, Hee Jin Park
    Endocrine.2022; 76(2): 341.     CrossRef
  • Approach to Bethesda system category III thyroid nodules according to US-risk stratification
    Jieun Kim, Jung Hee Shin, Young Lyun Oh, Soo Yeon Hahn, Ko Woon Park
    Endocrine Journal.2022; 69(1): 67.     CrossRef
  • Quantitative analysis of vascularity for thyroid nodules on ultrasound using superb microvascular imaging
    Min Ji Hong, Hye Shin Ahn, Su Min Ha, Hyun Jeong Park, Jiyun Oh
    Medicine.2022; 101(5): e28725.     CrossRef
  • Diagnostic Performance of Thyroid Core Needle Biopsy Using the Revised Reporting System: Comparison with Fine Needle Aspiration Cytology
    Kwangsoon Kim, Ja Seong Bae, Jeong Soo Kim, So Lyung Jung, Chan Kwon Jung
    Endocrinology and Metabolism.2022; 37(1): 159.     CrossRef
  • A Matched-Pair Analysis of Nuclear Morphologic Features Between Core Needle Biopsy and Surgical Specimen in Thyroid Tumors Using a Deep Learning Model
    Faridul Haq, Andrey Bychkov, Chan Kwon Jung
    Endocrine Pathology.2022; 33(4): 472.     CrossRef
  • Role of echogenic foci in ultrasonographic risk stratification of thyroid nodules: Echogenic focus scoring in the American College of Radiology Thyroid Imaging Reporting and Data System
    Renxu Li, Zhenwei Liang, Xiangyu Wang, Luzeng Chen
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Ultrasonographic characteristics of medullary thyroid carcinoma according to nodule size: application of the Korean Thyroid Imaging Reporting and Data System and American Thyroid Association guidelines
    Soo Yeon Hahn, Jung Hee Shin, Young Lyun Oh, Ko Woon Park
    Acta Radiologica.2021; 62(4): 474.     CrossRef
  • Malignancy risk of thyroid nodules with nonshadowing echogenic foci
    Yu-Mee Sohn, Dong Gyu Na, Wooyul Paik, Hye Yun Gwon, Byeong-Joo Noh
    Ultrasonography.2021; 40(1): 115.     CrossRef
  • Assessing the diagnostic performance of thyroid biopsy with recommendations for appropriate interpretation
    Su Min Ha, Jung Hwan Baek, Dong Gyu Na, Chan-Kwon Jung, Chong Hyun Suh, Young Kee Shong, Tae Yon Sung, Dong Eun Song, Jeong Hyun Lee
    Ultrasonography.2021; 40(2): 228.     CrossRef
  • Usage and Diagnostic Yield of Fine-Needle Aspiration Cytology and Core Needle Biopsy in Thyroid Nodules: A Systematic Review and Meta-Analysis of Literature Published by Korean Authors
    Soon-Hyun Ahn
    Clinical and Experimental Otorhinolaryngology.2021; 14(1): 116.     CrossRef
  • Comparison of the Efficacy and Safety of the American Thyroid Association Guidelines and American College of Radiology TI-RADS
    Jinghua Liu, Yajun Guo, Jiangxi Xiao, Luzeng Chen, Zhenwei Liang
    Endocrine Practice.2021; 27(7): 661.     CrossRef
  • Malignancy Rate of Bethesda Class III Thyroid Nodules Based on the Presence of Chronic Lymphocytic Thyroiditis in Surgical Patients
    Yoon Young Cho, Yun Jae Chung, Hee Sung Kim
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Efficacy of Differential Diagnosis of Thyroid Nodules by Shear Wave Elastography—the Stiffness Map
    Myung Hi Yoo, Hye Jeong Kim, In Ho Choi, Suyeon Park, Sumi Yun, Hyeong Kyu Park, Dong Won Byun, Kyoil Suh
    Journal of the Endocrine Society.2021;[Epub]     CrossRef
  • The relationship of thyroid nodule size on malignancy risk according to histological type of thyroid cancer
    Sae Rom Chung, Jung Hwan Baek, Young Jun Choi, Tae-Yon Sung, Dong Eun Song, Tae Yong Kim, Jeong Hyun Lee
    Acta Radiologica.2020; 61(5): 620.     CrossRef
  • Concordance of Three International Guidelines for Thyroid Nodules Classified by Ultrasonography and Diagnostic Performance of Biopsy Criteria
    Younghee Yim, Dong Gyu Na, Eun Ju Ha, Jung Hwan Baek, Jin Yong Sung, Ji-hoon Kim, Won-Jin Moon
    Korean Journal of Radiology.2020; 21(1): 108.     CrossRef
  • 2019 Practice guidelines for thyroid core needle biopsy: a report of the Clinical Practice Guidelines Development Committee of the Korean Thyroid Association
    Chan Kwon Jung, Jung Hwan Baek, Dong Gyu Na, Young Lyun Oh, Ka Hee Yi, Ho-Cheol Kang
    Journal of Pathology and Translational Medicine.2020; 54(1): 64.     CrossRef
  • Core-Needle Biopsy Does Not Show Superior Diagnostic Performance to Fine-Needle Aspiration for Diagnosing Thyroid Nodules
    Ilah Shin, Eun-Kyung Kim, Hee Jung Moon, Jung Hyun Yoon, Vivian Youngjean Park, Si Eun Lee, Hye Sun Lee, Jin Young Kwak
    Yonsei Medical Journal.2020; 61(2): 161.     CrossRef
  • Ultrasound‐guided fine‐needle aspiration or core needle biopsy for diagnosing follicular thyroid carcinoma?
    Ko Woon Park, Jung Hee Shin, Soo Yeon Hahn, Young Lyun Oh, Sun Wook Kim, Tae Hyuk Kim, Jae Hoon Chung
    Clinical Endocrinology.2020; 92(5): 468.     CrossRef
  • Distribution and malignancy risk of six categories of the pathology reporting system for thyroid core-needle biopsy in 1,216 consecutive thyroid nodules
    Hye Min Son, Ji-hoon Kim, Soo Chin Kim, Roh-Eul Yoo, Jeong Mo Bae, Hyobin Seo, Dong Gyu Na
    Ultrasonography.2020; 39(2): 159.     CrossRef
  • CT features of thyroid nodules with isolated macrocalcifications detected by ultrasonography
    Wooyul Paik, Dong Gyu Na, Hye Yun Gwon, Jinna Kim
    Ultrasonography.2020; 39(2): 130.     CrossRef
  • Contribution of cytologic examination to diagnosis of poorly differentiated thyroid carcinoma
    Na Rae Kim, Jae Yeon Seok, Yoo Seung Chung, Joon Hyop Lee, Dong Hae Chung
    Journal of Pathology and Translational Medicine.2020; 54(2): 171.     CrossRef
  • Comparison Between Fine Needle Aspiration and Core Needle Biopsy for the Diagnosis of Thyroid Nodules: Effective Indications According to US Findings
    Soo Yeon Hahn, Jung Hee Shin, Young Lyun Oh, Ko Woon Park, Yaeji Lim
    Scientific Reports.2020;[Epub]     CrossRef
  • Thyroid Nodules with Isolated Macrocalcifications: Malignancy Risk of Isolated Macrocalcifications and Postoperative Risk Stratification of Malignant Tumors Manifesting as Isolated Macrocalcifications
    Hye Yun Gwon, Dong Gyu Na, Byeong-Joo Noh, Wooyul Paik, So Jin Yoon, Soo-Jung Choi, Dong Rock Shin
    Korean Journal of Radiology.2020; 21(5): 605.     CrossRef
  • Diagnostic Efficacy and Safety of Core Needle Biopsy as a First-Line Diagnostic Method for Thyroid Nodules: A Prospective Cohort Study
    Min Ji Hong, Dong Gyu Na, Hunkyung Lee
    Thyroid.2020; 30(8): 1141.     CrossRef
  • Re: The 2019 core-needle biopsy practice guidelines
    Ji-hoon Kim
    Ultrasonography.2020; 39(3): 313.     CrossRef
  • Cytopathologic criteria and size should be considered in comparison of fine-needle aspiration vs. core-needle biopsy for thyroid nodules: results based on large surgical series
    Jung Hyun Yoon, Hye Sun Lee, Eun-Kyung Kim, Hee Jung Moon, Vivian Youngjean Park, Jin Young Kwak
    Endocrine.2020; 70(3): 558.     CrossRef
  • Preoperative diagnostic categories of fine needle aspiration cytology for histologically proven thyroid follicular adenoma and carcinoma, and Hurthle cell adenoma and carcinoma: Analysis of cause of under- or misdiagnoses
    Hee Young Na, Jae Hoon Moon, June Young Choi, Hyeong Won Yu, Woo-Jin Jeong, Yeo Koon Kim, Ji-Young Choe, So Yeon Park, Paula Soares
    PLOS ONE.2020; 15(11): e0241597.     CrossRef
  • The Role of Core Needle Biopsy for the Evaluation of Thyroid Nodules with Suspicious Ultrasound Features
    Sae Rom Chung, Jung Hwan Baek, Young Jun Choi, Tae-Yon Sung, Dong Eun Song, Tae Yong Kim, Jeong Hyun Lee
    Korean Journal of Radiology.2019; 20(1): 158.     CrossRef
  • Pathological diagnosis of thyroid nodules based on core needle biopsies: comparative study between core needle biopsies and resected specimens in 578 cases
    Yan Xiong, Limin Yan, Lin Nong, Yalin Zheng, Ting Li
    Diagnostic Pathology.2019;[Epub]     CrossRef
  • The Current Histologic Classification of Thyroid Cancer
    Sylvia L. Asa
    Endocrinology and Metabolism Clinics of North America.2019; 48(1): 1.     CrossRef
  • Core-needle biopsy in thyroid nodules: performance, accuracy, and complications
    Miguel Paja, Jose Luis del Cura, Rosa Zabala, Igone Korta, Aitziber Ugalde, José I. López
    European Radiology.2019; 29(9): 4889.     CrossRef
  • Ultrasound‐guided needle biopsy of large thyroid nodules: Core needle biopsy yields more reliable results than fine needle aspiration
    Hyeon Jin Lee, Young Joong Kim, Hye Yeon Han, Jae Young Seo, Cheol Mog Hwang, KeumWon Kim
    Journal of Clinical Ultrasound.2019; 47(5): 255.     CrossRef
  • Tumor Volume Doubling Time in Active Surveillance of Papillary Thyroid Carcinoma
    Hye-Seon Oh, Hyemi Kwon, Eyun Song, Min Ji Jeon, Tae Yong Kim, Jeong Hyun Lee, Won Bae Kim, Young Kee Shong, Ki-Wook Chung, Jung Hwan Baek, Won Gu Kim
    Thyroid.2019; 29(5): 642.     CrossRef
  • Role of Immunohistochemistry in Fine Needle Aspiration and Core Needle Biopsy of Thyroid Nodules
    Seulki Song, Hyojin Kim, Soon-Hyun Ahn
    Clinical and Experimental Otorhinolaryngology.2019; 12(2): 224.     CrossRef
  • Echogenic foci in thyroid nodules: diagnostic performance with combination of TIRADS and echogenic foci
    Su Min Ha, Yun Jae Chung, Hye Shin Ahn, Jung Hwan Baek, Sung Bin Park
    BMC Medical Imaging.2019;[Epub]     CrossRef
  • Risk of Malignancy According to the Sub-classification of Atypia of Undetermined Significance and Suspicious Follicular Neoplasm Categories in Thyroid Core Needle Biopsies
    Sae Rom Chung, Jung Hwan Baek, Jeong Hyun Lee, Yu-Mi Lee, Tae-Yon Sung, Ki-Wook Chung, Suck Joon Hong, Min Ji Jeon, Tae Yong Kim, Young Kee Shong, Won Bae Kim, Won Gu Kim, Dong Eun Song
    Endocrine Pathology.2019; 30(2): 146.     CrossRef
  • Thyroid core needle biopsy: patients’ pain and satisfaction compared to fine needle aspiration
    Hyo Jin Kim, Yeo Koon Kim, Jae Hoon Moon, June Young Choi, Sang Il Choi
    Endocrine.2019; 65(2): 365.     CrossRef
  • Does Radiofrequency Ablation Induce Neoplastic Changes in Benign Thyroid Nodules: A Preliminary Study
    Su Min Ha, Jun Young Shin, Jung Hwan Baek, Dong Eun Song, Sae Rom Chung, Young Jun Choi, Jeong Hyun Lee
    Endocrinology and Metabolism.2019; 34(2): 169.     CrossRef
  • Differential Diagnosis of Thyroid Follicular Neoplasm from Nodular Hyperplasia by Shear Wave Elastography
    Myung Hi Yoo, Hye Jeong Kim, In Ho Choi, Ji-Oh Mok, Hyeong Kyu Park, Dong Won Byun, Kyoil Suh
    Soonchunhyang Medical Science.2019; 25(1): 10.     CrossRef
  • Ultrasound-Guided Core Needle Biopsy Techniques for Intermediate or Low Suspicion Thyroid Nodules: Which Method is Effective for Diagnosis?
    Soo Yeon Hahn, Jung Hee Shin, Young Lyun Oh, Ko Woon Park
    Korean Journal of Radiology.2019; 20(10): 1454.     CrossRef
  • Preoperative Diagnostic Categories of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features in Thyroid Core Needle Biopsy and Its Impact on Risk of Malignancy
    Hee Young Na, Ji Won Woo, Jae Hoon Moon, June Young Choi, Woo-Jin Jeong, Yeo Koon Kim, Ji-Young Choe, So Yeon Park
    Endocrine Pathology.2019; 30(4): 329.     CrossRef
  • Utility of a formatted pathologic reporting system in thyroid core needle biopsy: A validation study of 1998 consecutive cases
    Ji‐Young Choe, Yoonjin Kwak, Mimi Kim, Yul Ri Chung, Hyun Jeong Kim, Yeo Koon Kim, So Yeon Park
    Clinical Endocrinology.2018; 88(1): 96.     CrossRef
  • Nuclear features of papillary thyroid carcinoma: Comparison of Core needle biopsy and thyroidectomy specimens
    Jae Yeon Seok, Jungsuk An, Hyun Yee Cho, Younghye Kim, Seung Yeon Ha
    Annals of Diagnostic Pathology.2018; 32: 35.     CrossRef
  • Prevention of total thyroidectomy in noninvasive follicular thyroid neoplasm with papillary‐like nuclear features (NIFTP) based on combined interpretation of ultrasonographic and cytopathologic results
    Sung‐Hye You, Kyu Eun Lee, Roh‐Eul Yoo, Hye Jeong Choi, Kyeong Cheon Jung, Jae‐Kyung Won, Koung Mi Kang, Tae Jin Yoon, Seung Hong Choi, Chul‐Ho Sohn, Ji‐hoon Kim
    Clinical Endocrinology.2018; 88(1): 114.     CrossRef
  • Statement and Recommendations on Interventional Ultrasound as a Thyroid Diagnostic and Treatment Procedure
    Christoph F. Dietrich, Thomas Müller, Jörg Bojunga, Yi Dong, Giovanni Mauri, Maija Radzina, Manjiri Dighe, Xin-Wu Cui, Frank Grünwald, Andreas Schuler, Andre Ignee, Huedayi Korkusuz
    Ultrasound in Medicine & Biology.2018; 44(1): 14.     CrossRef
  • Core needle biopsy of thyroid nodules: outcomes and safety from a large single-center single-operator study
    Jooae Choe, Jung Hwan Baek, Hye Sun Park, Young Jun Choi, Jeong Hyun Lee
    Acta Radiologica.2018; 59(8): 924.     CrossRef
  • Improvement of diagnostic performance of pathologists by reducing the number of pathologists responsible for thyroid fine needle aspiration cytology: An institutional experience
    Jae Yeon Seok, Jungsuk An, Hyun Yee Cho
    Diagnostic Cytopathology.2018; 46(7): 561.     CrossRef
  • Comparison of Immunohistochemistry and Direct Sanger Sequencing for Detection of theBRAFV600EMutation in Thyroid Neoplasm
    Hye-Seon Oh, Hyemi Kwon, Suyeon Park, Mijin Kim, Min Ji Jeon, Tae Yong Kim, Young Kee Shong, Won Bae Kim, Jene Choi, Won Gu Kim, Dong Eun Song
    Endocrinology and Metabolism.2018; 33(1): 62.     CrossRef
  • Comparison of the Diagnostic Efficacy of Ultrasound‐Guided Core Needle Biopsy With 18‐ Versus 20‐Gauge Needles for Thyroid Nodules
    Hye Shin Ahn, Mirinae Seo, Su Min Ha, Hee Sung Kim
    Journal of Ultrasound in Medicine.2018; 37(11): 2565.     CrossRef
  • Impact of Nodule Size on Malignancy Risk Differs according to the Ultrasonography Pattern of Thyroid Nodules
    Min Ji Hong, Dong Gyu Na, Jung Hwan Baek, Jin Yong Sung, Ji-Hoon Kim
    Korean Journal of Radiology.2018; 19(3): 534.     CrossRef
  • Web‐based thyroid imaging reporting and data system: Malignancy risk of atypia of undetermined significance or follicular lesion of undetermined significance thyroid nodules calculated by a combination of ultrasonography features and biopsy results
    Young Jun Choi, Jung Hwan Baek, Jung Hee Shin, Woo Hyun Shim, Seon‐Ok Kim, Won‐Hong Lee, Dong Eun Song, Tae Yong Kim, Ki‐Wook Chung, Jeong Hyun Lee
    Head & Neck.2018; 40(9): 1917.     CrossRef
  • Thyroid Incidentalomas Detected on18F-Fluorodeoxyglucose Positron Emission Tomography with Computed Tomography: Malignant Risk Stratification and Management Plan
    Sae Rom Chung, Young Jun Choi, Chong Hyun Suh, Hwa Jung Kim, Jong Jin Lee, Won Gu Kim, Tae Yon Sung, Yu-mi Lee, Dong Eun Song, Jeong Hyun Lee, Jung Hwan Baek
    Thyroid.2018; 28(6): 762.     CrossRef
  • The role of core needle biopsy in the diagnosis of initially detected thyroid nodules: a systematic review and meta-analysis
    Sae Rom Chung, Chong Hyun Suh, Jung Hwan Baek, Young Jun Choi, Jeong Hyun Lee
    European Radiology.2018; 28(11): 4909.     CrossRef
  • The History of Korean Thyroid Pathology
    Soon Won Hong, Chan Kwon Jung
    International Journal of Thyroidology.2018; 11(1): 15.     CrossRef
  • Ultrasonographic Echogenicity and Histopathologic Correlation of Thyroid Nodules in Core Needle Biopsy Specimens
    Ji-hoon Kim, Dong Gyu Na, Hunkyung Lee
    Korean Journal of Radiology.2018; 19(4): 673.     CrossRef
  • Evaluation of Modified Core-Needle Biopsy in the Diagnosis of Thyroid Nodules
    Soomin Ahn, Sejin Jung, Ji-Ye Kim, Jung Hee Shin, Soo Yeon Hahn, Young Lyun Oh
    Korean Journal of Radiology.2018; 19(4): 656.     CrossRef
  • Role of core needle biopsy as a first-line diagnostic tool for thyroid nodules: a retrospective cohort study
    Min Ji Hong, Dong Gyu Na, Soo Jin Kim, Dae Sik Kim
    Ultrasonography.2018; 37(3): 244.     CrossRef
  • Active Surveillance of Low-Risk Papillary Thyroid Microcarcinoma: A Multi-Center Cohort Study in Korea
    Hye-Seon Oh, Jeonghoon Ha, Hye In Kim, Tae Hyuk Kim, Won Gu Kim, Dong-Jun Lim, Tae Yong Kim, Sun Wook Kim, Won Bae Kim, Young Kee Shong, Jae Hoon Chung, Jung Hwan Baek
    Thyroid.2018; 28(12): 1587.     CrossRef
  • Risk of malignancy according to sub‐classification of the atypia of undetermined significance or follicular lesion of undetermined significance (AUS/FLUS) category in the Bethesda system for reporting thyroid cytopathology
    S. J. Kim, J. Roh, J. H. Baek, S. J. Hong, Y. K. Shong, W. B. Kim, D. E. Song
    Cytopathology.2017; 28(1): 65.     CrossRef
  • Fine-needle aspiration versus core needle biopsy for diagnosis of thyroid malignancy and neoplasm: a matched cohort study
    Soo-Yeon Kim, Hye Sun Lee, Jieun Moon, Eun-Kyung Kim, Hee Jung Moon, Jung Hyun Yoon, Jin Young Kwak
    European Radiology.2017; 27(2): 801.     CrossRef
  • Follicular variant of papillary thyroid carcinoma: comparison of ultrasound-guided core needle biopsy and ultrasound-guided fine needle aspiration in a multicentre study
    Soo Yeon Hahn, Jung Hee Shin, Hyun Kyung Lim, So Lyung Jung
    Clinical Endocrinology.2017; 86(1): 113.     CrossRef
  • Core‐needle biopsy versus repeat fine‐needle aspiration for thyroid nodules initially read as atypia/follicular lesion of undetermined significance
    Young Jun Choi, Jung Hwan Baek, Chong Hyun Suh, Woo Hyun Shim, Boseul Jeong, Jae Kyun Kim, Dong Eun Song, Tae Yong Kim, Ki‐Wook Chung, Jeong Hyun Lee
    Head & Neck.2017; 39(2): 361.     CrossRef
  • Preoperative differentiation between noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) and non-NIFTP
    Soo Yeon Hahn, Jung Hee Shin, Hyun Kyung Lim, So Lyung Jung, Young Lyun Oh, In Ho Choi, Chan Kwon Jung
    Clinical Endocrinology.2017; 86(3): 444.     CrossRef
  • Core Needle Biopsy of the Thyroid: 2016 Consensus Statement and Recommendations from Korean Society of Thyroid Radiology
    Dong Gyu Na, Jung Hwan Baek, So Lyung Jung, Ji-hoon Kim, Jin Yong Sung, Kyu Sun Kim, Jeong Hyun Lee, Jung Hee Shin, Yoon Jung Choi, Eun Ju Ha, Hyun Kyung Lim, Soo Jin Kim, Soo Yeon Hahn, Kwang Hwi Lee, Young Jun Choi, Inyoung Youn, Young Joong Kim, Hye Sh
    Korean Journal of Radiology.2017; 18(1): 217.     CrossRef
  • First-Line Use of Core Needle Biopsy for High-Yield Preliminary Diagnosis of Thyroid Nodules
    H.C. Kim, Y.J. Kim, H.Y. Han, J.M. Yi, J.H. Baek, S.Y. Park, J.Y. Seo, K.W. Kim
    American Journal of Neuroradiology.2017; 38(2): 357.     CrossRef
  • Ultrasound-Pathology Discordant Nodules on Core-Needle Biopsy: Malignancy Risk and Management Strategy
    Sae Rom Chung, Jung Hwan Baek, Hye Sun Park, Young Jun Choi, Tae-Yon Sung, Dong Eun Song, Tae Yong Kim, Jeong Hyun Lee
    Thyroid.2017; 27(5): 707.     CrossRef
  • Current status of core needle biopsy of the thyroid
    Jung Hwan Baek
    Ultrasonography.2017; 36(2): 83.     CrossRef
  • Cytology-Ultrasonography Risk-Stratification Scoring System Based on Fine-Needle Aspiration Cytology and the Korean-Thyroid Imaging Reporting and Data System
    Min Ji Hong, Dong Gyu Na, Jung Hwan Baek, Jin Yong Sung, Ji-Hoon Kim
    Thyroid.2017; 27(7): 953.     CrossRef
  • Preoperative clinicopathological characteristics of patients with solitary encapsulated follicular variants of papillary thyroid carcinomas
    Hyemi Kwon, Min Ji Jeon, Jong Ho Yoon, Suck Joon Hong, Jeong Hyun Lee, Tae Yong Kim, Young Kee Shong, Won Bae Kim, Won Gu Kim, Dong Eun Song
    Journal of Surgical Oncology.2017; 116(6): 746.     CrossRef
  • Active Surveillance for Patients With Papillary Thyroid Microcarcinoma: A Single Center’s Experience in Korea
    Hyemi Kwon, Hye-Seon Oh, Mijin Kim, Suyeon Park, Min Ji Jeon, Won Gu Kim, Won Bae Kim, Young Kee Shong, Dong Eun Song, Jung Hwan Baek, Ki-Wook Chung, Tae Yong Kim
    The Journal of Clinical Endocrinology & Metabolism.2017; 102(6): 1917.     CrossRef
  • Comparison of Consecutive Results from Fine Needle Aspiration and Core Needle Biopsy in Thyroid Nodules
    Soon-Hyun Ahn, So-Yeon Park, Sang Il Choi
    Endocrine Pathology.2017; 28(4): 332.     CrossRef
  • Efficacy and safety of core-needle biopsy in initially detected thyroid nodules via propensity score analysis
    Chong Hyun Suh, Jung Hwan Baek, Young Jun Choi, Tae Yong Kim, Tae Yon Sung, Dong Eun Song, Jeong Hyun Lee
    Scientific Reports.2017;[Epub]     CrossRef
  • Comparison of Core-Needle Biopsy and Fine-Needle Aspiration for Evaluating Thyroid Incidentalomas Detected by 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography: A Propensity Score Analysis
    Chong Hyun Suh, Young Jun Choi, Jong Jin Lee, Woo Hyun Shim, Jung Hwan Baek, Han Cheol Chung, Young Kee Shong, Dong Eun Song, Tae Yon Sung, Jeong Hyun Lee
    Thyroid.2017; 27(10): 1258.     CrossRef
  • Thyroid Fine-Needle Aspiration Cytology Practice in Korea
    Yoon Jin Cha, Ju Yeon Pyo, SoonWon Hong, Jae Yeon Seok, Kyung-Ju Kim, Jee-Young Han, Jeong Mo Bae, Hyeong Ju Kwon, Yeejeong Kim, Kyueng-Whan Min, Soonae Oak, Sunhee Chang
    Journal of Pathology and Translational Medicine.2017; 51(6): 521.     CrossRef
  • Recent Advances in Core Needle Biopsy for Thyroid Nodules
    Chan Kwon Jung, Jung Hwan Baek
    Endocrinology and Metabolism.2017; 32(4): 407.     CrossRef
  • Core-needle biopsy for the preoperative diagnosis of follicular neoplasm in thyroid nodule screening: A validation study
    Sung Hak Lee, Gyeong Sin Park, So Lyung Jung, Min-Hee Kim, Ja Seong Bae, Dong Jun Lim, Chan Kwon Jung
    Pathology - Research and Practice.2016; 212(1): 44.     CrossRef
  • The Role of Core-Needle Biopsy as a First-Line Diagnostic Tool for Initially Detected Thyroid Nodules
    Chong Hyun Suh, Jung Hwan Baek, Jeong Hyun Lee, Young Jun Choi, Jae Kyun Kim, Tae-Yon Sung, Jong Ho Yoon, Young Kee Shong
    Thyroid.2016; 26(3): 395.     CrossRef
  • Thyroid nodules with minimal cystic changes have a low risk of malignancy
    Dong Gyu Na, Ji-hoon Kim, Dea Sik Kim, Soo Jin Kim
    Ultrasonography.2016; 35(2): 153.     CrossRef
  • Thyroid nodules with isolated macrocalcification: malignancy risk and diagnostic efficacy of fine-needle aspiration and core needle biopsy
    Dong Gyu Na, Dae Sik Kim, Soo Jin Kim, Jae Wook Ryoo, So Lyung Jung
    Ultrasonography.2016; 35(3): 212.     CrossRef
  • Thyroid Imaging Reporting and Data System Risk Stratification of Thyroid Nodules: Categorization Based on Solidity and Echogenicity
    Dong Gyu Na, Jung Hwan Baek, Jin Yong Sung, Ji-Hoon Kim, Jae Kyun Kim, Young Jun Choi, Hyobin Seo
    Thyroid.2016; 26(4): 562.     CrossRef
  • Fine‐needle aspiration and core needle biopsy: An update on 2 common minimally invasive tissue sampling modalities
    Paul A. VanderLaan
    Cancer Cytopathology.2016; 124(12): 862.     CrossRef
  • The role of core-needle biopsy in the diagnosis of thyroid malignancy in 4580 patients with 4746 thyroid nodules: a systematic review and meta-analysis
    Chong Hyun Suh, Jung Hwan Baek, Jeong Hyun Lee, Young Jun Choi, Kyung Won Kim, Jayoun Lee, Ki-Wook Chung, Young Kee Shong
    Endocrine.2016; 54(2): 315.     CrossRef
  • The Role of Core-Needle Biopsy for Thyroid Nodules with Initially Nondiagnostic Fine-Needle Aspiration Results: A Systematic Review and Meta-Analysis
    Chong Hyun Suh, Jung Hwan Baek, Kyung Won Kim, Tae Yon Sung, Tae Yong Kim, Dong Eun Song, Young Jun Choi, Jeong Hyun Lee
    Endocrine Practice.2016; 22(6): 679.     CrossRef
  • Should Core Needle Biopsy be Used in the Evaluation of Thyroid Nodules?
    Beril Guler, Tugce Kiran, Dilek Sema Arici, Erhan Aysan, Fatma Cavide Sonmez
    Endocrine Pathology.2016; 27(4): 352.     CrossRef
  • A Multicenter Prospective Validation Study for the Korean Thyroid Imaging Reporting and Data System in Patients with Thyroid Nodules
    Eun Ju Ha, Won-Jin Moon, Dong Gyu Na, Young Hen Lee, Nami Choi, Soo Jin Kim, Jae Kyun Kim
    Korean Journal of Radiology.2016; 17(5): 811.     CrossRef
  • Impact of Reclassification on Thyroid Nodules with Architectural Atypia: From Non-Invasive Encapsulated Follicular Variant Papillary Thyroid Carcinomas to Non-Invasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features
    Min Ji Jeon, Dong Eun Song, Chan Kwon Jung, Won Gu Kim, Hyemi Kwon, Yu-Mi Lee, Tae-Yon Sung, Jong Ho Yoon, Ki-Wook Chung, Suck Joon Hong, Jung Hwan Baek, Jeong Hyun Lee, Tae Yong Kim, Young Kee Shong, Won Bae Kim, Rafael Rosell
    PLOS ONE.2016; 11(12): e0167756.     CrossRef
Original Article
Finding and Characterizing Mammary Analogue Secretory Carcinoma of the Salivary Gland
Min Jung Jung, Joon Seon Song, Sang Yoon Kim, Soon Yuhl Nam, Jong-Lyel Roh, Seung-Ho Choi, Sung-Bae Kim, Kyung-Ja Cho
Korean J Pathol. 2013;47(1):36-43.   Published online February 25, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.1.36
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AbstractAbstract PDF
Background

A new tumor entity of the salivary glands, mammary analogue secretory carcinoma (MASC) with ETV6-NTRK3 translocation, has recently been proposed. MASC was originally diagnosed as adenocarcinoma, not otherwise specified (ANOS), or acinic cell carcinoma (AciCC) by the current World Health Organization classification. We aimed to identify MASC cases by molecular tests, and to characterize their clinical, histological, and immunohistochemical features.

Methods

Thirty cases of MASC candidates were selected after review of 196 salivary gland tumors, and subjected to break-apart ETV6 fluorescence in situ hybridization (FISH), and immunohistochemical study for S100 protein, gross cystic disease fluid protein 15, DOG1, estrogen receptor, and progesterone receptor.

Results

Valid FISH results were obtained in 23 cases, and 13 positive cases were retrieved. MASCs were histologically varied, and the most frequent features observed in 10 cases were low-grade papillary/cystic/glandular patterns, intraluminal secretory materials, ovoid/wrinkled nuclei, and relatively abundant granular eosinophilic cytoplasms, corresponding to papillary-cystic or follicular types of AciCC. All cases showed diffuse immunopositivity for S100 protein. Three cases developed recurrences, but all patients remained alive.

Conclusions

MASC could be a molecularly well-defined salivary gland neoplasm, encompassing some portions of AciCC and ANOS, but its histological spectrum and clinical implication require further investigation.

Citations

Citations to this article as recorded by  
  • Salivary Gland Secretory Carcinoma; Review of 13 Years World‐Wide Experience and Meta‐Analysis
    Eyal Yosefof, Tomer Boldes, Daniel Dan, Eyal Robenshtok, Yulia Strenov, Gideon Bachar, Thomas Shpitzer, Aviram Mizrachi
    The Laryngoscope.2024; 134(4): 1716.     CrossRef
  • Salivary gland secretory carcinoma presenting as a cervical soft tissue mass: a case report
    Parisa Mokhles, Alireza Sadeghipour, Pegah Babaheidarian, Saleh Mohebbi, Zahra Keshtpour Amlashi, Mohammad Hadi Gharib, Mohammad Saeid Ahmadi, Zeinab Khastkhodaei
    Journal of Medical Case Reports.2024;[Epub]     CrossRef
  • Mammary analogue secretory carcinoma of the head and neck — Clinicopathological, imaging features and prognosis analysis
    Runjia Liu, Chuanzheng Sun, Likang Zhao, Shiyu Zhou, Tao Xie, Ji Zhang, Dengpeng Tang, Lei Li, Yan Xi
    Journal of Radiation Research and Applied Sciences.2024; : 100914.     CrossRef
  • Metastatic salivary gland mammary analogue secretory carcinoma (MASC) of parotid gland – A rare case report in the literature review
    Aynur Aliyeva, Ziya Karimov, Togay Muderris
    Acta Oto-Laryngologica Case Reports.2023; 8(1): 38.     CrossRef
  • Secretory carcinoma of minor salivary glands of buccal mucosa: A case report and review of the literature
    Noshad Ali Langah, Abdul Ahad, Shayan Khalid Ghaloo, Muhammad Faisal, Raza Tasawar Hussain, Fareed Akbar Shah
    International Journal of Surgery Case Reports.2023; 107: 108357.     CrossRef
  • An Underappreciated Cytomorphological Feature of Secretory Carcinoma of Salivary Gland on Fine Needle Aspiration Biopsy: Case Report with Literature Review
    Yinan Hua, Bing Leng, Kenneth E. Youens, Lina Liu
    Head and Neck Pathology.2022; 16(2): 567.     CrossRef
  • Clinicopathological investigation of secretory carcinoma cases including a successful treatment outcome using entrectinib for high-grade transformation: a case report
    Kensuke Suzuki, Hiroshi Harada, Masayuki Takeda, Chisato Ohe, Yoshiko Uemura, Akihiko Kawahara, Shunsuke Sawada, Akira Kanda, Bhaswati Sengupta, Hiroshi Iwai
    BMC Medical Genomics.2022;[Epub]     CrossRef
  • DOG1 as an Immunohistochemical Marker of Acinic Cell Carcinoma: A Systematic Review and Meta-Analysis
    Vincenzo Fiorentino, Patrizia Straccia, Pietro Tralongo, Teresa Musarra, Francesco Pierconti, Maurizio Martini, Guido Fadda, Esther Diana Rossi, Luigi Maria Larocca
    International Journal of Molecular Sciences.2022; 23(17): 9711.     CrossRef
  • Secretory carcinoma of the sinonasal cavity and pharynx: A retrospective analysis of four cases and literature review
    Changli Yue, Xiaoli Zhao, Donglin Ma, Yingshi Piao
    Annals of Diagnostic Pathology.2022; 61: 152052.     CrossRef
  • Secretory carcinoma of the salivary gland: a multi‐institutional clinicopathologic study of 90 cases with emphasis on grading and prognostic factors
    Bin Xu, Kartik Viswanathan, Kavita Umrau, Thair A. D. Al‐Ameri, Snjezana Dogan, Kelly Magliocca, Ronald A. Ghossein, Nicole A. Cipriani, Nora Katabi
    Histopathology.2022; 81(5): 670.     CrossRef
  • A systematic review of secretory carcinoma of the salivary gland: where are we?
    Lísia Daltro Borges Alves, Andreia Cristina de Melo, Thayana Alves Farinha, Luiz Henrique de Lima Araujo, Leandro de Souza Thiago, Fernando Luiz Dias, Héliton Spíndola Antunes, Ana Lucia Amaral Eisenberg, Luiz Claudio Santos Thuler, Daniel Cohen Goldember
    Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.2021; 132(4): e143.     CrossRef
  • A case report of surgical resection of secretory carcinoma in the maxillary and ethmoid sinus
    Kurt Willis, Martin Bullock, Matthew H. Rigby
    International Journal of Surgery Case Reports.2021; 81: 105750.     CrossRef
  • High‐grade salivary gland carcinoma with the ETV6‐NTRK3 gene fusion: A case report and literature review of secretory carcinoma with high‐grade transformation
    Satsuki Asai, Shinji Sumiyoshi, Yosuke Yamada, Ichiro Tateya, Toshitaka Nagao, Sachiko Minamiguchi, Hironori Haga
    Pathology International.2021; 71(6): 427.     CrossRef
  • High-grade Transformation/Dedifferentiation in Salivary Gland Carcinomas: Occurrence Across Subtypes and Clinical Significance
    Alena Skalova, Ilmo Leivo, Henrik Hellquist, Abbas Agaimy, Roderick H.W. Simpson, Göran Stenman, Vincent Vander Poorten, Justin A. Bishop, Alessandro Franchi, Juan C. Hernandez-Prera, David Slouka, Stefan M. Willems, Kerry D. Olsen, Alfio Ferlito
    Advances in Anatomic Pathology.2021; 28(3): 107.     CrossRef
  • Radiological features of head and neck mammary analogue secretory carcinoma: 11 new cases with a systematic review of 29 cases reported in 28 publications
    Ryo Kurokawa, Mariko Kurokawa, Akira Baba, Yoshiaki Ota, Toshio Moritani, Ashok Srinivasan
    Neuroradiology.2021; 63(11): 1901.     CrossRef
  • A case of secretory carcinoma of the salivary glands in the lower lip
    Reiko OHARA, Haruki SATO, Kensuke NAGANAWA, Taihei HAYAKAWA, Tatsuya KATAOKA, Ichiro OH-IWA
    Japanese Journal of Oral and Maxillofacial Surgery.2021; 67(2): 83.     CrossRef
  • Undifferentiated and dedifferentiated head and neck carcinomas
    Alessandro Franchi, Alena Skalova
    Seminars in Diagnostic Pathology.2021; 38(6): 127.     CrossRef
  • Cytopathological Findings of Secretory Carcinoma of the Salivary Gland and the Diagnostic Utility of Giemsa Staining
    Yuria Egusa, Midori Filiz Nishimura, Satoko Baba, Kengo Takeuchi, Takuma Makino, Tomoyasu Tachibana, Asami Nishikori, Azusa Fujita, Hiroyuki Yanai, Yasuharu Sato
    Diagnostics.2021; 11(12): 2284.     CrossRef
  • Diagnosis and treatment of secretory carcinoma arising from the oral minor salivary gland
    Masaru Ogawa, Satoshi Yokoo, Takahiro Yamaguchi, Keisuke Suzuki, Mai Seki-Soda, Takahiro Shimizu, Jun Kurihara, Takaya Makiguchi
    Medicine.2021; 100(51): e28390.     CrossRef
  • A biphasic sessile mass of the buccal mucosa
    Tiffany M. Peters, James A. Phero, Brent A. Golden, Alice E. Curran
    Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.2020; 130(6): 612.     CrossRef
  • Don't stop the champions of research now: a brief history of head and neck pathology developments
    Lester D.R. Thompson, James S. Lewis, Alena Skálová, Justin A. Bishop
    Human Pathology.2020; 95: 1.     CrossRef
  • High Grade Transformation in Mucoepidermoid Carcinoma of the Minor Salivary Gland with Polyploidy of the Rearranged MAML2 Gene
    Hyun Lee, Jong-Lyel Roh, Young-Jun Choi, Jene Choi, Kyung-Ja Cho
    Head and Neck Pathology.2020; 14(3): 822.     CrossRef
  • Pan‐Trk immunohistochemistry is a sensitive and specific ancillary tool for diagnosing secretory carcinoma of the salivary gland and detecting ETV6–NTRK3 fusion
    Bin Xu, Mohamed R Haroon Al Rasheed, Cristina R Antonescu, Deepu Alex, Denise Frosina, Ronald Ghossein, Achim A Jungbluth, Nora Katabi
    Histopathology.2020; 76(3): 375.     CrossRef
  • Characterization of novel genetic alterations in salivary gland secretory carcinoma
    Kiyong Na, Juan C. Hernandez-Prera, Jae-Yol Lim, Ha Young Woo, Sun Och Yoon
    Modern Pathology.2020; 33(4): 541.     CrossRef
  • Mammary analogue secretory carcinoma: An Indian experience of a novel entity
    Zeba Nisar, JaydeepN Pol, RakhiV Jagdale, MadhuraD Phadke, GirishA Kadkol
    Indian Journal of Pathology and Microbiology.2020; 63(5): 134.     CrossRef
  • Secretory Carcinoma of Salivary Gland with High-Grade Histology Arising in Hard Palate: A Case Report
    Kiyofumi Takabatake, Keisuke Nakano, Hotaka Kawai, Saori Yoshida, Haruka Omori, May Wathone Oo, Shan Qiusheng, Kenichiro Uchida, Katsuaki Mishima, Hitoshi Nagatsuka
    Reports — Medical Cases, Images, and Videos.2020; 3(2): 6.     CrossRef
  • Secretory carcinoma of the salivary gland (mammary analogue secretory carcinoma) in children
    I. V. Sidorov, I. S. Kletskaya, D. M. Konovalov
    Arkhiv patologii.2020; 82(2): 43.     CrossRef
  • Secretory carcinoma of the major salivary gland: Provincial population‐based analysis of clinical behavior and outcomes
    Gareth Ayre, Martin Hyrcza, Jonn Wu, Eric Berthelet, Alena Skálová, Tom Thomson
    Head & Neck.2019; 41(5): 1227.     CrossRef
  • Higher Ki67 Index, Nodal Involvement, and Invasive Growth Were High Risk Factors for Worse Prognosis in Conventional Mammary Analogue Secretory Carcinoma
    Jingjing Sun, Lizhen Wang, Zhen Tian, Yuhua Hu, Ronghui Xia, Jiang Li
    Journal of Oral and Maxillofacial Surgery.2019; 77(6): 1187.     CrossRef
  • Mammary analogue secretory carcinoma of salivary gland diagnosed on submandibular gland cytology: A case report and review of the literature
    Ethar Al‐Husseinawi, Soheila Hamidpour, Evanthia Omoscharka
    Cytopathology.2019; 30(3): 318.     CrossRef
  • Secretory Carcinoma of Minor Salivary Gland in Buccal Mucosa: A Case Report and Review of the Literature
    Durga Paudel, Michiko Nishimura, Bhoj Raj Adhikari, Daichi Hiraki, Aya Onishi, Tetsuro Morikawa, Puja Neopane, Sarita Giri, Koki Yoshida, Jun Sato, Masayuki Ono, Yoshitaka Kamino, Hiroki Nagayasu, Yoshihiro Abiko
    Case Reports in Pathology.2019; 2019: 1.     CrossRef
  • Estrogen Receptor, Progesterone Receptor, and HER-2 Expression in Recurrent Pleomorphic Adenoma
    Ana Amélia de Souza, Albina Altemani, Ney Soares de Araujo, Lucas Novaes Texeira, Vera Cavalcanti de Araújo, Andresa Borges Soares
    Clinical Pathology.2019; 12: 2632010X1987338.     CrossRef
  • Sinonasal Secretory Carcinoma of Salivary Gland with High Grade Transformation: A Case Report of this Under-Recognized Diagnostic Entity with Prognostic and Therapeutic Implications
    Bin Xu, Ruth Aryeequaye, Lu Wang, Nora Katabi
    Head and Neck Pathology.2018; 12(2): 274.     CrossRef
  • Primary mammary analogue secretory carcinoma of the lung: a case report
    Tao Huang, Jonathan B. McHugh, Gerald J. Berry, Jeffrey L. Myers
    Human Pathology.2018; 74: 109.     CrossRef
  • Salivary Secretory Carcinoma With a Novel ETV6-MET Fusion
    Lisa M. Rooper, Theodoros Karantanos, Yi Ning, Justin A. Bishop, Sarah W. Gordon, Hyunseok Kang
    American Journal of Surgical Pathology.2018; 42(8): 1121.     CrossRef
  • Secretory carcinoma: The eastern Canadian experience and literature review
    David Forner, Martin Bullock, Daniel Manders, Timothy Wallace, Christopher J. Chin, Liane B. Johnson, Matthew H. Rigby, Jonathan R. Trites, Mark S. Taylor, Robert D. Hart
    Journal of Otolaryngology - Head & Neck Surgery.2018;[Epub]     CrossRef
  • Newly described salivary gland tumors
    Alena Skalova, Michal Michal, Roderick HW Simpson
    Modern Pathology.2017; 30: S27.     CrossRef
  • Diagnóstico, tratamiento y seguimiento de un tumor de reciente descripción: el carcinoma análogo secretor de mama (MASC) de glándula salival. A propósito de 2 nuevos casos
    Marina Alexandra Gavín-Clavero, M. Victoria Simón-Sanz, Ana M. López-López, Alberto Valero-Torres, Esther Saura-Fillat
    Revista Española de Cirugía Oral y Maxilofacial.2017; 39(4): 221.     CrossRef
  • Systematic review of mammary analog secretory carcinoma of salivary glands at 7 years after description
    Bacem A. Khalele
    Head & Neck.2017; 39(6): 1243.     CrossRef
  • Salivary Gland Secretory Carcinoma With High-Grade Transformation, CDKN2A/B Loss, Distant Metastasis, and Lack of Sustained Response to Crizotinib
    Nicole A. Cipriani, Elizabeth A. Blair, Joshua Finkle, Jennifer L. Kraninger, Christopher M. Straus, Victoria M. Villaflor, Daniel Thomas Ginat
    International Journal of Surgical Pathology.2017; 25(7): 613.     CrossRef
  • A systematic review including an additional pediatric case report: Pediatric cases of mammary analogue secretory carcinoma
    Amanda L. Ngouajio, Sarah M. Drejet, D. Ryan Phillips, Don-John Summerlin, John P. Dahl
    International Journal of Pediatric Otorhinolaryngology.2017; 100: 187.     CrossRef
  • Newly Described Entities in Salivary Gland Pathology
    Alena Skálová, Douglas R. Gnepp, James S. Lewis, Jennifer L. Hunt, Justin A. Bishop, Henrik Hellquist, Alessandra Rinaldo, Vincent Vander Poorten, Alfio Ferlito
    American Journal of Surgical Pathology.2017; 41(8): e33.     CrossRef
  • Mammary Analogue Secretory Carcinoma of Salivary Glands: Diagnostic Pitfall with Distinct Immunohistochemical Profile and Molecular Features
    Oliver Bissinger, Carolin Götz, Andreas Kolk, Henning A. Bier, Abbas Agaimy, Henning Frenzel, Sven Perner, Julika Ribbat-Idel, Klaus Dietrich Wolff, Wilko Weichert, Caroline Mogler
    Rare Tumors.2017; 9(3): 89.     CrossRef
  • Mammary Analogue Secretory Carcinoma of Salivary Gland. A Case Report Emphasizing its Diagnostic Histological, Immunohistochemistry and Molecular Findings
    Monalisa Hui, Shantveer G Uppin, Vamshi Krishna Thamtam, Abhiram Kalle
    International Journal of Head and Neck Surgery.2017; 8(4): 160.     CrossRef
  • A case of mammary analog secretory carcinoma of the lower lip
    Takako Aizawa, Taro Okui, Ken Kitagawa, Yoshikazu Kobayashi, Koji Satoh, Hideki Mizutani
    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology.2016; 28(3): 277.     CrossRef
  • Mammary analogue secretory carcinoma of parotid: Is preoperative cytological diagnosis possible?
    Nikita Oza, Kintan Sanghvi, Tanuja Shet, Asawari Patil, Santosh Menon, Mukta Ramadwar, Shubhada Kane
    Diagnostic Cytopathology.2016; 44(6): 519.     CrossRef
  • Lysozyme Expression Can be Useful to Distinguish Mammary Analog Secretory Carcinoma from Acinic Cell Carcinoma of Salivary Glands
    Fernanda Viviane Mariano, Camila Andrea Concha Gómez, Juliana de Souza do Nascimento, Harim Tavares dos Santos, Erika Said Egal, Victor Angelo Martins Montalli, Pablo Agustin Vargas, Oslei Paes de Almeida, Albina Altemani
    Head and Neck Pathology.2016; 10(4): 429.     CrossRef
  • Cytogenetic and immunohistochemical characterization of mammary analogue secretory carcinoma of salivary glands
    Syed A. Khurram, Jemel Sultan-Khan, Neil Atkey, Paul M. Speight
    Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.2016; 122(6): 731.     CrossRef
  • The role of DOG1 immunohistochemistry in dermatopathology
    Keisuke Goto
    Journal of Cutaneous Pathology.2016; 43(11): 974.     CrossRef
  • Extended immunologic and genetic lineage of mammary analogue secretory carcinoma of salivary glands
    Hao Ni, Xue-ping Zhang, Xiao-tong Wang, Qiu-yuan Xia, Jing-huan Lv, Xuan Wang, Shan-shan Shi, Rui Li, Xiao-jun Zhou, Qiu Rao
    Human Pathology.2016; 58: 97.     CrossRef
  • A New Hitherto Unreported Histopathologic Manifestation of Mammary Analogue Secretory Carcinoma: “Masked MASC” Associated With Low-grade Mucinous Adenocarcinoma and Low-grade In Situ Carcinoma Components
    Fredrik Petersson, Michael Michal, Dmitry V. Kazakov, Petr Grossmann, Michal Michal
    Applied Immunohistochemistry & Molecular Morphology.2016; 24(9): e80.     CrossRef
  • Papillary-cystic pattern is characteristic in mammary analogue secretory carcinomas but is rarely observed in acinic cell carcinomas of the salivary gland
    Min-Shu Hsieh, Yueh-Hung Chou, Shin-Joe Yeh, Yih-Leong Chang
    Virchows Archiv.2015; 467(2): 145.     CrossRef
  • Mammary analog secretory carcinoma, low-grade salivary duct carcinoma, and mimickers: a comparative study
    Todd M Stevens, Andra O Kovalovsky, Claudia Velosa, Qiuying Shi, Qian Dai, Randall P Owen, Walter C Bell, Shi Wei, Pamela A Althof, Jennifer N Sanmann, Larissa Sweeny, William R Carroll, Gene P Siegal, Martin J Bullock, Margaret Brandwein-Gensler
    Modern Pathology.2015; 28(8): 1084.     CrossRef
  • Aspiration cytology of mammary analogue secretory carcinoma of the salivary gland
    Min Jung Jung, Sang Yoon Kim, Soon Yuhl Nam, Jong‐Lyel Roh, Seung‐Ho Choi, Jeong Hyun Lee, Jung Hwan Baek, Kyung‐Ja Cho
    Diagnostic Cytopathology.2015; 43(4): 287.     CrossRef
  • A Unique Case of a Cutaneous Lesion Resembling Mammary Analog Secretory Carcinoma
    Jennifer Albus, Jacqueline Batanian, Bruce M. Wenig, Claudia I. Vidal
    The American Journal of Dermatopathology.2015; 37(4): e41.     CrossRef
  • Mammary analogue secretory carcinoma of salivary glands: a new entity associated with ETV6 gene rearrangement
    Hanna Majewska, Alena Skálová, Dominik Stodulski, Adéla Klimková, Petr Steiner, Czesław Stankiewicz, Wojciech Biernat
    Virchows Archiv.2015; 466(3): 245.     CrossRef
  • A comparative immunohistochemistry study of diagnostic tools in salivary gland tumors: usefulness of mammaglobin, gross cystic disease fluid protein 15, and p63 cytoplasmic staining for the diagnosis of mammary analog secretory carcinoma?
    Fabrice Projetti, Magali Lacroix‐Triki, Elie Serrano, Sebastien Vergez, Béatrice Herbault Barres, Julie Meilleroux, Marie‐Bernadette Delisle, Emmanuelle Uro‐Coste
    Journal of Oral Pathology & Medicine.2015; 44(4): 244.     CrossRef
  • Mammary Analogue Secretory Carcinoma of Salivary Glands
    Yohei Ito, Kenichiro Ishibashi, Ayako Masaki, Kana Fujii, Yukio Fujiyoshi, Hideo Hattori, Daisuke Kawakita, Manabu Matsumoto, Satoru Miyabe, Kazuo Shimozato, Toshitaka Nagao, Hiroshi Inagaki
    American Journal of Surgical Pathology.2015; 39(5): 602.     CrossRef
  • Cytopathological features of mammary analogue secretory carcinoma—Review of literature
    Maiko Takeda, Takahiko Kasai, Kohei Morita, Mao Takeuchi, Takeshi Nishikawa, Akinori Yamashita, Shinji Mikami, Hiroshi Hosoi, Chiho Ohbayashi
    Diagnostic Cytopathology.2015; 43(2): 131.     CrossRef
  • Mammary Analog Secretory Carcinoma of Salivary Glands
    Justin A. Bishop
    Pathology Case Reviews.2015; 20(1): 7.     CrossRef
  • Diagnostic utility of phosphorylated signal transducer and activator of transcription 5 immunostaining in the diagnosis of mammary analogue secretory carcinoma of the salivary gland: A comparative study of salivary gland cancers
    Akihiko Kawahara, Tomoki Taira, Hideyuki Abe, Yorihiko Takase, Takashi Kurita, Eiji Sadashima, Satoshi Hattori, Ichio Imamura, Shinji Matsumoto, Hitomi Fujisaki, Kazunobu Sueyoshi, Jun Akiba, Masayoshi Kage
    Cancer Cytopathology.2015; 123(10): 603.     CrossRef
  • A Case of Mammary Analogue Secretory Carcinoma Arising from Parotid Gland
    Hee Tae Kim, Cha Hee Lee, Han Su Kim, Hae Sang Park
    Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2015; 58(8): 563.     CrossRef
  • WITHDRAWN: A biphasic sessile mass of the buccal mucosa
    Tiffany M. Peters, Jose P. Zevallos, Brent A. Golden, Alice E. Curran
    Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.2015;[Epub]     CrossRef
  • Mammary analogue secretory carcinoma: an evaluation of its clinicopathological and genetic characteristics
    Peter P. Luk, Christina I. Selinger, Timothy J. Eviston, Trina Lum, Bing Yu, Sandra A. O’Toole, Jonathan R. Clark, Ruta Gupta
    Pathology.2015; 47(7): 659.     CrossRef
  • A case of mammary analogue secretory carcinoma arising in the submandibular region
    Kotaro ISHII, Koji NAKAMATSU, Koji SATO, Chikashi MINEMURA, Wataru KUMAMARU, Hiroyo YOSHIKAWA
    Japanese Journal of Oral and Maxillofacial Surgery.2015; 61(11): 564.     CrossRef
  • DOG1, p63, and S100 protein: a novel immunohistochemical panel in the differential diagnosis of oncocytic salivary gland neoplasms in fine-needle aspiration cell blocks
    Alessandra C. Schmitt, Ryan McCormick, Cynthia Cohen, Momin T. Siddiqui
    Journal of the American Society of Cytopathology.2014; 3(6): 303.     CrossRef
  • Salivary Gland Tumor “Wishes” to Add to the Next WHO Tumor Classification: Sclerosing Polycystic Adenosis, Mammary Analogue Secretory Carcinoma, Cribriform Adenocarcinoma of the Tongue and Other Sites, and Mucinous Variant of Myoepithelioma
    Douglas R. Gnepp
    Head and Neck Pathology.2014; 8(1): 42.     CrossRef
  • Hepatoid differentiation in renal cell carcinoma: a rare histologic pattern with clinical significance
    Jungweon Shim, Heounjeong Go, Young-Suk Lim, Kyung Chul Moon, Jae Y. Ro, Yong Mee Cho
    Annals of Diagnostic Pathology.2014; 18(6): 363.     CrossRef
  • Mammary analogue secretory carcinoma: Update on a new diagnosis of salivary gland malignancy
    Roshan Sethi, Elliott Kozin, Aaron Remenschneider, Josh Meier, Paul VanderLaan, William Faquin, Daniel Deschler, Robert Frankenthaler
    The Laryngoscope.2014; 124(1): 188.     CrossRef
  • Mammary analog secretory carcinoma of salivary gland in a 5 year old: Case report
    Matthew Keisling, Michael Bianchi, Judy Mae Pascasio
    International Journal of Pediatric Otorhinolaryngology Extra.2014; 9(4): 163.     CrossRef
  • Fine-Needle Aspiration Cytology of Mammary Analog Secretory Carcinoma Masquerading as Low-Grade Mucoepidermoid Carcinoma: Case Report with a Review of the Literature
    Jaya Bajaj, Cecilia Gimenez, Farah Slim, Mohamed Aziz, Kasturi Das
    Acta Cytologica.2014; 58(5): 501.     CrossRef
Review
Introduction to digital pathology and computer-aided pathology
Soojeong Nam, Yosep Chong, Chan Kwon Jung, Tae-Yeong Kwak, Ji Youl Lee, Jihwan Park, Mi Jung Rho, Heounjeong Go
J Pathol Transl Med. 2020;54(2):125-134.   Published online February 13, 2020
DOI: https://doi.org/10.4132/jptm.2019.12.31
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AbstractAbstract PDF
Digital pathology (DP) is no longer an unfamiliar term for pathologists, but it is still difficult for many pathologists to understand the engineering and mathematics concepts involved in DP. Computer-aided pathology (CAP) aids pathologists in diagnosis. However, some consider CAP a threat to the existence of pathologists and are skeptical of its clinical utility. Implementation of DP is very burdensome for pathologists because technical factors, impact on workflow, and information technology infrastructure must be considered. In this paper, various terms related to DP and computer-aided pathologic diagnosis are defined, current applications of DP are discussed, and various issues related to implementation of DP are outlined. The development of computer-aided pathologic diagnostic tools and their limitations are also discussed.

Citations

Citations to this article as recorded by  
  • Performance of externally validated machine learning models based on histopathology images for the diagnosis, classification, prognosis, or treatment outcome prediction in female breast cancer: A systematic review
    Ricardo Gonzalez, Peyman Nejat, Ashirbani Saha, Clinton J.V. Campbell, Andrew P. Norgan, Cynthia Lokker
    Journal of Pathology Informatics.2024; 15: 100348.     CrossRef
  • Invisible for a few but essential for many: the role of Histotechnologists in the establishment of digital pathology
    Gisela Magalhães, Rita Calisto, Catarina Freire, Regina Silva, Diana Montezuma, Sule Canberk, Fernando Schmitt
    Journal of Histotechnology.2024; 47(1): 39.     CrossRef
  • Using digital pathology to analyze the murine cerebrovasculature
    Dana M Niedowicz, Jenna L Gollihue, Erica M Weekman, Panhavuth Phe, Donna M Wilcock, Christopher M Norris, Peter T Nelson
    Journal of Cerebral Blood Flow & Metabolism.2024; 44(4): 595.     CrossRef
  • PATrans: Pixel-Adaptive Transformer for edge segmentation of cervical nuclei on small-scale datasets
    Hexuan Hu, Jianyu Zhang, Tianjin Yang, Qiang Hu, Yufeng Yu, Qian Huang
    Computers in Biology and Medicine.2024; 168: 107823.     CrossRef
  • CNAC-Seg: Effective segmentation for cervical nuclei in adherent cells and clusters via exploring gaps of receptive fields
    Hexuan Hu, Jianyu Zhang, Tianjin Yang, Qiang Hu, Yufeng Yu, Qian Huang
    Biomedical Signal Processing and Control.2024; 90: 105833.     CrossRef
  • Artificial Intelligence-Enabled Prostate Cancer Diagnosis and Prognosis: Current State and Future Implications
    Swati Satturwar, Anil V. Parwani
    Advances in Anatomic Pathology.2024; 31(2): 136.     CrossRef
  • Ensemble Deep Learning Model to Predict Lymphovascular Invasion in Gastric Cancer
    Jonghyun Lee, Seunghyun Cha, Jiwon Kim, Jung Joo Kim, Namkug Kim, Seong Gyu Jae Gal, Ju Han Kim, Jeong Hoon Lee, Yoo-Duk Choi, Sae-Ryung Kang, Ga-Young Song, Deok-Hwan Yang, Jae-Hyuk Lee, Kyung-Hwa Lee, Sangjeong Ahn, Kyoung Min Moon, Myung-Giun Noh
    Cancers.2024; 16(2): 430.     CrossRef
  • Artificial intelligence’s impact on breast cancer pathology: a literature review
    Amr Soliman, Zaibo Li, Anil V. Parwani
    Diagnostic Pathology.2024;[Epub]     CrossRef
  • Automated Analysis of Nuclear Parameters in Oral Exfoliative Cytology Using Machine Learning
    Shubhangi Mhaske, Karthikeyan Ramalingam, Preeti Nair, Shubham Patel, Arathi Menon P, Nida Malik, Sumedh Mhaske
    Cureus.2024;[Epub]     CrossRef
  • Blockchain: A safe digital technology to share cancer diagnostic results in pandemic times—Challenges and legacy for the future
    Bruno Natan Santana Lima, Lucas Alves da Mota Santana, Rani Iani Costa Gonçalo, Carla Samily de Oliveira Costa, Daniel Pitanga de Sousa Nogueira, Cleverson Luciano Trento, Wilton Mitsunari Takeshita
    Oral Surgery.2023; 16(3): 300.     CrossRef
  • Pathologists’ acceptance of telepathology in the Ministry of National Guard Health Affairs Hospitals in Saudi Arabia: A survey study
    Raneem Alawashiz, Sharifah Abdullah AlDossary
    DIGITAL HEALTH.2023; 9: 205520762311636.     CrossRef
  • An Atrous Convolved Hybrid Seg-Net Model with residual and attention mechanism for gland detection and segmentation in histopathological images
    Manju Dabass, Jyoti Dabass
    Computers in Biology and Medicine.2023; 155: 106690.     CrossRef
  • Validation of a Machine Learning Expert Supporting System, ImmunoGenius, Using Immunohistochemistry Results of 3000 Patients with Lymphoid Neoplasms
    Jamshid Abdul-Ghafar, Kyung Jin Seo, Hye-Ra Jung, Gyeongsin Park, Seung-Sook Lee, Yosep Chong
    Diagnostics.2023; 13(7): 1308.     CrossRef
  • Diagnosing Infectious Diseases in Poultry Requires a Holistic Approach: A Review
    Dieter Liebhart, Ivana Bilic, Beatrice Grafl, Claudia Hess, Michael Hess
    Poultry.2023; 2(2): 252.     CrossRef
  • Recent application of artificial intelligence on histopathologic image-based prediction of gene mutation in solid cancers
    Mohammad Rizwan Alam, Kyung Jin Seo, Jamshid Abdul-Ghafar, Kwangil Yim, Sung Hak Lee, Hyun-Jong Jang, Chan Kwon Jung, Yosep Chong
    Briefings in Bioinformatics.2023;[Epub]     CrossRef
  • Canine Mammary Tumor Histopathological Image Classification via Computer-Aided Pathology: An Available Dataset for Imaging Analysis
    Giovanni P. Burrai, Andrea Gabrieli, Marta Polinas, Claudio Murgia, Maria Paola Becchere, Pierfranco Demontis, Elisabetta Antuofermo
    Animals.2023; 13(9): 1563.     CrossRef
  • Rapid digital pathology of H&E-stained fresh human brain specimens as an alternative to frozen biopsy
    Bhaskar Jyoti Borah, Yao-Chen Tseng, Kuo-Chuan Wang, Huan-Chih Wang, Hsin-Yi Huang, Koping Chang, Jhih Rong Lin, Yi-Hua Liao, Chi-Kuang Sun
    Communications Medicine.2023;[Epub]     CrossRef
  • Applied machine learning in hematopathology
    Taher Dehkharghanian, Youqing Mu, Hamid R. Tizhoosh, Clinton J. V. Campbell
    International Journal of Laboratory Hematology.2023; 45(S2): 87.     CrossRef
  • Automated diagnosis of 7 canine skin tumors using machine learning on H&E-stained whole slide images
    Marco Fragoso-Garcia, Frauke Wilm, Christof A. Bertram, Sophie Merz, Anja Schmidt, Taryn Donovan, Andrea Fuchs-Baumgartinger, Alexander Bartel, Christian Marzahl, Laura Diehl, Chloe Puget, Andreas Maier, Marc Aubreville, Katharina Breininger, Robert Klopf
    Veterinary Pathology.2023; 60(6): 865.     CrossRef
  • Artificial Intelligence in the Pathology of Gastric Cancer
    Sangjoon Choi, Seokhwi Kim
    Journal of Gastric Cancer.2023; 23(3): 410.     CrossRef
  • Efficient Convolution Network to Assist Breast Cancer Diagnosis and Target Therapy
    Ching-Wei Wang, Kai-Lin Chu, Hikam Muzakky, Yi-Jia Lin, Tai-Kuang Chao
    Cancers.2023; 15(15): 3991.     CrossRef
  • Artificial intelligence for automatic detection of basal cell carcinoma from frozen tissue tangential biopsies
    Dennis H Murphree, Yong-hun Kim, Kirk A Sidey, Nneka I Comfere, Nahid Y Vidal
    Clinical and Experimental Dermatology.2023;[Epub]     CrossRef
  • Multi-Configuration Analysis of DenseNet Architecture for Whole Slide Image Scoring of ER-IHC
    Wan Siti Halimatul Munirah Wan Ahmad, Mohammad Faizal Ahmad Fauzi, Md Jahid Hasan, Zaka Ur Rehman, Jenny Tung Hiong Lee, See Yee Khor, Lai-Meng Looi, Fazly Salleh Abas, Afzan Adam, Elaine Wan Ling Chan, Sei-Ichiro Kamata
    IEEE Access.2023; 11: 79911.     CrossRef
  • Digitization of Pathology Labs: A Review of Lessons Learned
    Lars Ole Schwen, Tim-Rasmus Kiehl, Rita Carvalho, Norman Zerbe, André Homeyer
    Laboratory Investigation.2023; 103(11): 100244.     CrossRef
  • Artificial Intelligence in Endoscopic Ultrasonography-Guided Fine-Needle Aspiration/Biopsy (EUS-FNA/B) for Solid Pancreatic Lesions: Opportunities and Challenges
    Xianzheng Qin, Taojing Ran, Yifei Chen, Yao Zhang, Dong Wang, Chunhua Zhou, Duowu Zou
    Diagnostics.2023; 13(19): 3054.     CrossRef
  • Deep Learning for the Pathologic Diagnosis of Hepatocellular Carcinoma, Cholangiocarcinoma, and Metastatic Colorectal Cancer
    Hyun-Jong Jang, Jai-Hyang Go, Younghoon Kim, Sung Hak Lee
    Cancers.2023; 15(22): 5389.     CrossRef
  • AIR-UNet++: a deep learning framework for histopathology image segmentation and detection
    Anusree Kanadath, J. Angel Arul Jothi, Siddhaling Urolagin
    Multimedia Tools and Applications.2023;[Epub]     CrossRef
  • Deep Learning-Based Dermatological Condition Detection: A Systematic Review With Recent Methods, Datasets, Challenges, and Future Directions
    Stephanie S. Noronha, Mayuri A. Mehta, Dweepna Garg, Ketan Kotecha, Ajith Abraham
    IEEE Access.2023; 11: 140348.     CrossRef
  • Digital pathology and artificial intelligence in translational medicine and clinical practice
    Vipul Baxi, Robin Edwards, Michael Montalto, Saurabh Saha
    Modern Pathology.2022; 35(1): 23.     CrossRef
  • Artificial Intelligence in Toxicological Pathology: Quantitative Evaluation of Compound-Induced Follicular Cell Hypertrophy in Rat Thyroid Gland Using Deep Learning Models
    Valeria Bertani, Olivier Blanck, Davy Guignard, Frederic Schorsch, Hannah Pischon
    Toxicologic Pathology.2022; 50(1): 23.     CrossRef
  • Investigating the genealogy of the literature on digital pathology: a two-dimensional bibliometric approach
    Dayu Hu, Chengyuan Wang, Song Zheng, Xiaoyu Cui
    Scientometrics.2022; 127(2): 785.     CrossRef
  • Digital Dermatopathology and Its Application to Mohs Micrographic Surgery
    Yeongjoo Oh, Hye Min Kim, Soon Won Hong, Eunah Shin, Jihee Kim, Yoon Jung Choi
    Yonsei Medical Journal.2022; 63(Suppl): S112.     CrossRef
  • Assessment of parathyroid gland cellularity by digital slide analysis
    Rotem Sagiv, Bertha Delgado, Oleg Lavon, Vladislav Osipov, Re'em Sade, Sagi Shashar, Ksenia M. Yegodayev, Moshe Elkabets, Ben-Zion Joshua
    Annals of Diagnostic Pathology.2022; 58: 151907.     CrossRef
  • PancreaSys: An Automated Cloud-Based Pancreatic Cancer Grading System
    Muhammad Nurmahir Mohamad Sehmi, Mohammad Faizal Ahmad Fauzi, Wan Siti Halimatul Munirah Wan Ahmad, Elaine Wan Ling Chan
    Frontiers in Signal Processing.2022;[Epub]     CrossRef
  • Classification of Mouse Lung Metastatic Tumor with Deep Learning
    Ha Neul Lee, Hong-Deok Seo, Eui-Myoung Kim, Beom Seok Han, Jin Seok Kang
    Biomolecules & Therapeutics.2022; 30(2): 179.     CrossRef
  • Techniques for digital histological morphometry of the pineal gland
    Bogdan-Alexandru Gheban, Horaţiu Alexandru Colosi, Ioana-Andreea Gheban-Roșca, Carmen Georgiu, Dan Gheban, Doiniţa Crişan, Maria Crişan
    Acta Histochemica.2022; 124(4): 151897.     CrossRef
  • Current Trend of Artificial Intelligence Patents in Digital Pathology: A Systematic Evaluation of the Patent Landscape
    Muhammad Joan Ailia, Nishant Thakur, Jamshid Abdul-Ghafar, Chan Kwon Jung, Kwangil Yim, Yosep Chong
    Cancers.2022; 14(10): 2400.     CrossRef
  • Recent Applications of Artificial Intelligence from Histopathologic Image-Based Prediction of Microsatellite Instability in Solid Cancers: A Systematic Review
    Mohammad Rizwan Alam, Jamshid Abdul-Ghafar, Kwangil Yim, Nishant Thakur, Sung Hak Lee, Hyun-Jong Jang, Chan Kwon Jung, Yosep Chong
    Cancers.2022; 14(11): 2590.     CrossRef
  • Development of a prognostic prediction support system for cervical intraepithelial neoplasia using artificial intelligence-based diagnosis
    Takayuki Takahashi, Hikaru Matsuoka, Rieko Sakurai, Jun Akatsuka, Yusuke Kobayashi, Masaru Nakamura, Takashi Iwata, Kouji Banno, Motomichi Matsuzaki, Jun Takayama, Daisuke Aoki, Yoichiro Yamamoto, Gen Tamiya
    Journal of Gynecologic Oncology.2022;[Epub]     CrossRef
  • Digital Pathology and Artificial Intelligence Applications in Pathology
    Heounjeong Go
    Brain Tumor Research and Treatment.2022; 10(2): 76.     CrossRef
  • Mass spectrometry imaging to explore molecular heterogeneity in cell culture
    Tanja Bien, Krischan Koerfer, Jan Schwenzfeier, Klaus Dreisewerd, Jens Soltwisch
    Proceedings of the National Academy of Sciences.2022;[Epub]     CrossRef
  • Integrating artificial intelligence in pathology: a qualitative interview study of users' experiences and expectations
    Jojanneke Drogt, Megan Milota, Shoko Vos, Annelien Bredenoord, Karin Jongsma
    Modern Pathology.2022; 35(11): 1540.     CrossRef
  • Deep Learning on Basal Cell Carcinoma In Vivo Reflectance Confocal Microscopy Data
    Veronika Shavlokhova, Michael Vollmer, Patrick Gholam, Babak Saravi, Andreas Vollmer, Jürgen Hoffmann, Michael Engel, Christian Freudlsperger
    Journal of Personalized Medicine.2022; 12(9): 1471.     CrossRef
  • Deep Learning-Based Classification of Uterine Cervical and Endometrial Cancer Subtypes from Whole-Slide Histopathology Images
    JaeYen Song, Soyoung Im, Sung Hak Lee, Hyun-Jong Jang
    Diagnostics.2022; 12(11): 2623.     CrossRef
  • A self-supervised contrastive learning approach for whole slide image representation in digital pathology
    Parsa Ashrafi Fashi, Sobhan Hemati, Morteza Babaie, Ricardo Gonzalez, H.R. Tizhoosh
    Journal of Pathology Informatics.2022; 13: 100133.     CrossRef
  • A Matched-Pair Analysis of Nuclear Morphologic Features Between Core Needle Biopsy and Surgical Specimen in Thyroid Tumors Using a Deep Learning Model
    Faridul Haq, Andrey Bychkov, Chan Kwon Jung
    Endocrine Pathology.2022; 33(4): 472.     CrossRef
  • Development of quality assurance program for digital pathology by the Korean Society of Pathologists
    Yosep Chong, Jeong Mo Bae, Dong Wook Kang, Gwangil Kim, Hye Seung Han
    Journal of Pathology and Translational Medicine.2022; 56(6): 370.     CrossRef
  • Machine learning in renal pathology
    Matthew Nicholas Basso, Moumita Barua, Julien Meyer, Rohan John, April Khademi
    Frontiers in Nephrology.2022;[Epub]     CrossRef
  • Whole Slide Image Quality in Digital Pathology: Review and Perspectives
    Romain Brixtel, Sebastien Bougleux, Olivier Lezoray, Yann Caillot, Benoit Lemoine, Mathieu Fontaine, Dalal Nebati, Arnaud Renouf
    IEEE Access.2022; 10: 131005.     CrossRef
  • Generalizability of Deep Learning System for the Pathologic Diagnosis of Various Cancers
    Hyun-Jong Jang, In Hye Song, Sung Hak Lee
    Applied Sciences.2021; 11(2): 808.     CrossRef
  • Recent advances in the use of stimulated Raman scattering in histopathology
    Martin Lee, C. Simon Herrington, Manasa Ravindra, Kristel Sepp, Amy Davies, Alison N. Hulme, Valerie G. Brunton
    The Analyst.2021; 146(3): 789.     CrossRef
  • Preference and Demand for Digital Pathology and Computer-Aided Diagnosis among Korean Pathologists: A Survey Study Focused on Prostate Needle Biopsy
    Soo Jeong Nam, Yosep Chong, Chan Kwon Jung, Tae-Yeong Kwak, Ji Youl Lee, Jihwan Park, Mi Jung Rho, Heounjeong Go
    Applied Sciences.2021; 11(16): 7380.     CrossRef
  • An SVM approach towards breast cancer classification from H&E-stained histopathology images based on integrated features
    M. A. Aswathy, M. Jagannath
    Medical & Biological Engineering & Computing.2021; 59(9): 1773.     CrossRef
  • Diagnosis prediction of tumours of unknown origin using ImmunoGenius, a machine learning-based expert system for immunohistochemistry profile interpretation
    Yosep Chong, Nishant Thakur, Ji Young Lee, Gyoyeon Hwang, Myungjin Choi, Yejin Kim, Hwanjo Yu, Mee Yon Cho
    Diagnostic Pathology.2021;[Epub]     CrossRef
  • Deep Learning for Automatic Subclassification of Gastric Carcinoma Using Whole-Slide Histopathology Images
    Hyun-Jong Jang, In-Hye Song, Sung-Hak Lee
    Cancers.2021; 13(15): 3811.     CrossRef
  • A novel evaluation method for Ki-67 immunostaining in paraffin-embedded tissues
    Eliane Pedra Dias, Nathália Silva Carlos Oliveira, Amanda Oliveira Serra-Campos, Anna Karoline Fausto da Silva, Licínio Esmeraldo da Silva, Karin Soares Cunha
    Virchows Archiv.2021; 479(1): 121.     CrossRef
  • Assessment of Digital Pathology Imaging Biomarkers Associated with Breast Cancer Histologic Grade
    Andrew Lagree, Audrey Shiner, Marie Angeli Alera, Lauren Fleshner, Ethan Law, Brianna Law, Fang-I Lu, David Dodington, Sonal Gandhi, Elzbieta A. Slodkowska, Alex Shenfield, Katarzyna J. Jerzak, Ali Sadeghi-Naini, William T. Tran
    Current Oncology.2021; 28(6): 4298.     CrossRef
  • Prediction of genetic alterations from gastric cancer histopathology images using a fully automated deep learning approach
    Hyun-Jong Jang, Ahwon Lee, Jun Kang, In Hye Song, Sung Hak Lee
    World Journal of Gastroenterology.2021; 27(44): 7687.     CrossRef
  • Clustered nuclei splitting based on recurrent distance transform in digital pathology images
    Lukasz Roszkowiak, Anna Korzynska, Dorota Pijanowska, Ramon Bosch, Marylene Lejeune, Carlos Lopez
    EURASIP Journal on Image and Video Processing.2020;[Epub]     CrossRef
  • Current Trends of Artificial Intelligence for Colorectal Cancer Pathology Image Analysis: A Systematic Review
    Nishant Thakur, Hongjun Yoon, Yosep Chong
    Cancers.2020; 12(7): 1884.     CrossRef
  • A bird’s-eye view of deep learning in bioimage analysis
    Erik Meijering
    Computational and Structural Biotechnology Journal.2020; 18: 2312.     CrossRef
  • Pathomics in urology
    Victor M. Schuettfort, Benjamin Pradere, Michael Rink, Eva Comperat, Shahrokh F. Shariat
    Current Opinion in Urology.2020; 30(6): 823.     CrossRef
  • Model Fooling Attacks Against Medical Imaging: A Short Survey
    Tuomo Sipola, Samir Puuska, Tero Kokkonen
    Information & Security: An International Journal.2020; 46(2): 215.     CrossRef
  • Recommendations for pathologic practice using digital pathology: consensus report of the Korean Society of Pathologists
    Yosep Chong, Dae Cheol Kim, Chan Kwon Jung, Dong-chul Kim, Sang Yong Song, Hee Jae Joo, Sang-Yeop Yi
    Journal of Pathology and Translational Medicine.2020; 54(6): 437.     CrossRef
  • A machine-learning expert-supporting system for diagnosis prediction of lymphoid neoplasms using a probabilistic decision-tree algorithm and immunohistochemistry profile database
    Yosep Chong, Ji Young Lee, Yejin Kim, Jingyun Choi, Hwanjo Yu, Gyeongsin Park, Mee Yon Cho, Nishant Thakur
    Journal of Pathology and Translational Medicine.2020; 54(6): 462.     CrossRef
Original Articles
WHO Classification of Malignant Lymphomas in Korea: Report of the Third Nationwide Study.
Jin Man Kim, Young Hyeh Ko, Seung Sook Lee, Jooryung Huh, Chang Suk Kang, Chul Woo Kim, Yun Kyung Kang, Jai Hyang Go, Min Kyung Kim, Wan Seop Kim, Yoon Jung Kim, Hyun Jung Kim, Hee Kyung Kim, Jong Hee Nam, Hyung Bae Moon, Chan Kum Park, Tae In Park, Young Ha Oh, Dong Wha Lee, Jong Sil Lee, Juhie Lee, Hyekyung Lee, Sung Chul Lim, Kyu Yun Jang, Hee Kyung Chang, Yoon Kyung Jeon, Hye Ra Jung, Min Sun Cho, Hee Jeong Cha, Suk Jin Choi, Jae Ho Han, Sook Hee Hong, Insun Kim
Korean J Pathol. 2011;45(3):254-260.
DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.3.254
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AbstractAbstract PDF
BACKGROUND
The aim of study was to determine the relative frequency of malignant lymphoma according to World Health Organization (WHO) classification in Korea.
METHODS
A total of 3,998 cases diagnosed at 31 institutes between 2005 and 2006 were enrolled. Information including age, gender, pathologic diagnosis, site of involvement and immunophenotypes were obtained.
RESULTS
The relative frequency of non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL) was 95.4% and 4.6%, respectively. B-cell lymphomas accounted for 77.6% of all NHL, while T/natural killer (T/NK)-cell lymphomas accounted for 22.4%. The most frequent subtypes of NHL were diffuse large B-cell lymphoma (42.7%), extranodal marginal zone B-cell lymphoma (MZBCL) of mucosa-associated lymphoid tissue (19.0%), NK/T-cell lymphoma (6.3%) and peripheral T-cell lymphoma (PTCL), unspecified (6.3%), in decreasing order. The relative frequency of HL was nodular sclerosis (47.4%), mixed cellularity (30.6%), and nodular lymphocyte predominant (12.1%) subtypes. Compared with a previous study in 1998, increase in gastric MZBCL and nodular sclerosis HL, and slight decrease of follicular lymphoma, PTCL, and NK/T-cell lymphoma were observed.
CONCLUSIONS
Korea had lower rates of HL and follicular lymphoma, and higher rates of extranodal NHL, extranodal MZBCL, and NK/T-cell lymphoma of nasal type compared with Western countries. Changes in the relative frequency of lymphoma subtypes are likely ascribed to refined diagnostic criteria and a change in national health care policy.

Citations

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  • Pattern of Bone Marrow Involvement in B-cell Non-Hodgkin's Lymphoma - Experience from a Tertiary Care Center in North India
    Shareefa Akhter, Nusrat Bashir, MohmadHussain Mir, Fahim Manzoor, Maniza Ayub, MalikTariq Rasool, Sheikh Bilal
    Journal of Radiation and Cancer Research.2023;[Epub]     CrossRef
  • Identification and overcoming rituximab resistance in diffuse large B-cell lymphoma using next-generation sequencing
    Min Ji Jeon, Eun Sang Yu, Chul Won Choi, Dae Sik Kim
    The Korean Journal of Internal Medicine.2023; 38(6): 893.     CrossRef
  • Estimating the global burden of Epstein–Barr virus-related cancers
    Yide Wong, Michael T. Meehan, Scott R. Burrows, Denise L. Doolan, John J. Miles
    Journal of Cancer Research and Clinical Oncology.2022; 148(1): 31.     CrossRef
  • Epidemiological Characteristics of Peripheral T-Cell Lymphoma: A Population-Based Study
    Shuo Liu, Weiping Liu, Huichao Li, Lei Yang, Yuqin Song, Xi Zhang, Yangyang Cheng, Qingyu Li, Haoxin Li, Ning Wang, Jun Zhu, Jiafu Ji
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Structure and Function of Ligand CX3CL1 and its Receptor CX3CR1 in Cancer
    Xinjie Lu
    Current Medicinal Chemistry.2022; 29(41): 6228.     CrossRef
  • Clinical course of duodenal mucosa‐associated lymphoid tissue lymphoma: Comparison with gastric mucosa‐associated lymphoid tissue lymphoma
    Hee Kyong Na, Sung Hyun Won, Ji Yong Ahn, Ga Hee Kim, Kee Wook Jung, Jeong Hoon Lee, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon‐Yong Jung, Hwa Jung Kim
    Journal of Gastroenterology and Hepatology.2021; 36(2): 406.     CrossRef
  • Real-world data on the survival outcome of patients with newly diagnosed Waldenström macroglobulinemia
    Jang Ho Cho, Joon-Ho Shim, Sang Eun Yoon, Hee-Jin Kim, Sun-Hee Kim, Young Hyeh Ko, Seung-Tae Lee, Kihyun Kim, Won Seog Kim, Seok Jin Kim
    The Korean Journal of Internal Medicine.2021; 36(3): 668.     CrossRef
  • Primary Gastrointestinal T/NK Cell Lymphoma
    Eun Kyung Kim, Mi Jang, Woo Ick Yang, Sun Och Yoon
    Cancers.2021; 13(11): 2679.     CrossRef
  • Mucosa-Associated Lymphoid Tissue Lymphoma of the Cheek Mimicking Benign Entities: a Case Report
    Hyun Hwang, Jae Ho Shin, Yon Kwon Ihn, Sungjun Han, Hong Sik Park
    Investigative Magnetic Resonance Imaging.2021; 25(2): 129.     CrossRef
  • Classification of non-Hodgkin lymphoma in the Middle Euphrates Region of Iraq according to the World Health Organization classification
    Ahmed Mjali, AlyaaHadi Oudah, HaiderHasan Jaleel Al-Shammari, NareenTawfeeq Abbas
    Iraqi Journal of Hematology.2021; 10(2): 170.     CrossRef
  • Epstein-Barr virus NK and T cell lymphoproliferative disease: report of a 2018 international meeting
    Jeffrey I. Cohen, Keiji Iwatsuki, Young-Hyeh Ko, Hiroshi Kimura, Irini Manoli, Koichi Ohshima, Stefania Pittaluga, Leticia Quintanilla-Martinez, Elaine S. Jaffe
    Leukemia & Lymphoma.2020; 61(4): 808.     CrossRef
  • Cutaneous lymphoma in Japan, 2012–2017: A nationwide study
    Kazuyasu Fujii, Toshihisa Hamada, Takatoshi Shimauchi, Jun Asai, Yasuhiro Fujisawa, Hironobu Ihn, Norito Katoh
    Journal of Dermatological Science.2020; 97(3): 187.     CrossRef
  • Practical Approach to the Histologic Diagnosis of Gastrointestinal Lymphomas Through the First-line Marker Battery of CD20, CD3, CD30, and Epstein-Barr Virus–encoded RNAs
    Eun Kyung Kim, Woo Ick Yang, Hyang Joo Ryu, Hee Lee Ji, Sun Och Yoon
    Advances in Anatomic Pathology.2020; 27(2): 75.     CrossRef
  • Treatment of mantle cell lymphoma in Asia: a consensus paper from the Asian Lymphoma Study Group
    Dok Hyun Yoon, Junning Cao, Tsai-Yun Chen, Koji Izutsu, Seok Jin Kim, Yok Lam Kwong, Tong Yu Lin, Lim Soon Thye, Bing Xu, Deok Hwan Yang, Won Seog Kim
    Journal of Hematology & Oncology.2020;[Epub]     CrossRef
  • Morphologic variant of follicular lymphoma reminiscent of hyaline-vascular Castleman disease
    Jiwon Koh, Yoon Kyung Jeon
    Journal of Pathology and Translational Medicine.2020; 54(3): 253.     CrossRef
  • Discovery of Novel Recurrent Mutations and Clinically Meaningful Subgroups in Nodal Marginal Zone Lymphoma
    Jiwon Koh, Insoon Jang, Seongmin Choi, Sehui Kim, Ingeon Jang, Hyun Kyung Ahn, Cheol Lee, Jin Ho Paik, Chul Woo Kim, Megan S. Lim, Kwangsoo Kim, Yoon Kyung Jeon
    Cancers.2020; 12(6): 1669.     CrossRef
  • Clinicopathological and Immunophenotype Spectrum of Malignant Lymphoma in Eastern India Population – A Tertiary Care Hospital Study
    Debahuti Mohapatra, Rajashree Tripathy, Prateek Das, Pallak Batalia
    Journal of Evidence Based Medicine and Healthcare.2020; 7(38): 2120.     CrossRef
  • Cost-utility analysis of pralatrexate for relapsed or refractory peripheral T-cell lymphoma based on a case-matched historical control study along with single arm clinical trial
    Seonyoung Park, Ah-Young Kim, Hyeonseok Cho, Deborah Baik, Hankil Lee, Sunghwa Cho, Hye-Young Kang
    BMC Cancer.2020;[Epub]     CrossRef
  • Extranodal non-Hodgkin’s lymphoma: A case series at a tertiary care hospital
    Pomilla Singh, Ravi Swami, Shashank Singh, N S Mani, M N Karandikar
    IP Archives of Cytology and Histopathology Research.2020; 5(4): 302.     CrossRef
  • Pediatric non‐Hodgkin lymphoma: Characteristics, stratification, and treatment at a single institute in Thailand
    Worawut Choeyprasert, Usanarat Anurathapan, Samart Pakakasama, Nongnuch Sirachainan, Duantida Songdej, Surapong Lertthammakiat, Suradej Hongeng
    Pediatrics International.2019; 61(1): 49.     CrossRef
  • Epstein-Barr Virus-Associated T and NK-Cell Lymphoproliferative Diseases
    Wook Youn Kim, Ivonne A. Montes-Mojarro, Falko Fend, Leticia Quintanilla-Martinez
    Frontiers in Pediatrics.2019;[Epub]     CrossRef
  • Chimeric Antigen Receptor T-Cell Therapy for Diffuse Large B-Cell Lymphoma
    Heejung Chae, Dok Hyun Yoon
    The Korean Journal of Medicine.2019; 94(2): 152.     CrossRef
  • Classification of malignant lymphoma subtypes in Korean patients: a report of the 4th nationwide study
    Hye-Ra Jung, Jooryung Huh, Young-Hyeh Ko, Yoon Kyung Jeon, Sun Och Yoon, Se Hoon Kim, Woo Ick Yang, Geongsin Park, Jo Heon Kim, Jin Ho Paik, Jae Ho Han, Hee Jung Cha, Kyu Yun Jang, Bong-Kyung Shin, Young-A Kim, Ji Eun Kim, Yoo Duk Choi, Min Gyoung Park, H
    Journal of Hematopathology.2019; 12(4): 173.     CrossRef
  • Phase II study of R–CVP followed by rituximab maintenance therapy for patients with advanced marginal zone lymphoma: consortium for improving survival of lymphoma (CISL) study
    Sung Yong Oh, Won Seog Kim, Jin Seok Kim, Seok Jin Kim, Dok Hyun Yoon, Deok‐Hwan Yang, Won Sik Lee, Hyo Jung Kim, Ho‐Young Yhim, Seong Hyun Jeong, Jong Ho Won, Suee Lee, Jee Hyun Kong, Sung‐Nam Lim, Jun Ho Ji, Kyung A. Kwon, Gyeong‐Won Lee, Jae Hoon Lee,
    Cancer Communications.2019; 39(1): 1.     CrossRef
  • Changing trends in lymphoid neoplasm distribution in South Korea: analysis of 8615 cases from a single institute, 1997–2016
    Jongmin Sim, Takuya Takayama, Junhun Cho, Seok Jin Kim, Won Seog Kim, Howe J. Ree, Young Hyeh Ko
    Medicine.2019; 98(45): e17641.     CrossRef
  • Non‐Hodgkin lymphoma in South East Asia: An analysis of the histopathology, clinical features, and survival from Thailand
    Tanin Intragumtornchai, Udomsak Bunworasate, Kitsada Wudhikarn, Arnuparp Lekhakula, Jakrawadi Julamanee, Kanchana Chansung, Chittima Sirijerachai, Lalita Norasetthada, Weerasak Nawarawong, Archrob Khuhapinant, Noppadol Siritanaratanakul, Tontanai Numbenja
    Hematological Oncology.2018; 36(1): 28.     CrossRef
  • Prevalence and Implications of Bone Marrow Involvement in Patients with Gastric Mucosa-Associated Lymphoid Tissue Lymphoma
    Sang Il Choi, Myeong-Cherl Kook, Sanghyun Hwang, Young-Il Kim, Jong Yeul Lee, Chan Gyoo Kim, Il Ju Choi, Hyewon Lee, Hyeon Seok Eom, Soo-Jeong Cho
    Gut and Liver.2018; 12(3): 278.     CrossRef
  • A Case of Synchronous Lung Squamous Cell Carcinoma and Diffuse Large B-cell Lymphoma
    Seung Jae Lee, Si Young Lim, Tae Kyung Yoo, Seul Ki Kim, You Gyung Kim, Hyun Joo Lee, Jae Uk Song
    The Korean Journal of Medicine.2018; 93(3): 300.     CrossRef
  • A risk stratification model for nodal peripheral T-cell lymphomas based on the NCCN-IPI and posttreatment Deauville score
    Ho-Young Yhim, Yong Park, Yeon-Hee Han, Sungeun Kim, Sae-Ryung Kang, Joon-Ho Moon, Ju Hye Jeong, Ho-Jin Shin, Keunyoung Kim, Yoon Seok Choi, Kunho Kim, Min Kyoung Kim, Eunjung Kong, Dae Sik Kim, Jae Seon Eo, Ji Hyun Lee, Do-Young Kang, Won Sik Lee, Seok M
    European Journal of Nuclear Medicine and Molecular Imaging.2018; 45(13): 2274.     CrossRef
  • Low-grade follicular lymphoma involvement of the bone marrow with a mixed paratrabecular, diffuse, and massive pattern expressing typical mantle cell lymphoma immunophenotype CD23−/FMC7+: a case report
    Jaewook Kim, Ji-Hun Lim, Joseph Jeong, Seon-Ho Lee, Jae-Cheol Jo, Sang Hyuk Park
    Blood Research.2018; 53(3): 261.     CrossRef
  • Aspectos epidemiológicos, clínicos e anatomopatológicos do linfoma folicular em cães
    Renata D. Mazaro, Isis P.J. Rizkallah, Flávia S. Luz, Douglas M. Lorensetti, Bruno Cogliati, Rafael A. Fighera
    Pesquisa Veterinária Brasileira.2018; 38(9): 1772.     CrossRef
  • Serious fungal infections in Korea
    K. Huh, Y. E. Ha, D. W. Denning, K. R. Peck
    European Journal of Clinical Microbiology & Infectious Diseases.2017; 36(6): 957.     CrossRef
  • Epidural Lymphoma Mimicking Hematoma: A Case Report
    Dong-Yeong Lee, Soon-Taek Jeong, Kun-Tae Kim, Jung-Wook Yang, Dong-Hee Kim
    Journal of Korean Society of Spine Surgery.2017; 24(1): 49.     CrossRef
  • Geographical Correlations between Indoor Radon Concentration and Risks of Lung Cancer, Non-Hodgkin’s Lymphoma, and Leukemia during 1999–2008 in Korea
    Mina Ha, Seung-sik Hwang, Sungchan Kang, No-Wook Park, Byung-Uck Chang, Yongjae Kim
    International Journal of Environmental Research and Public Health.2017; 14(4): 344.     CrossRef
  • Platelet to lymphocyte ratio (PLR) retains independent prognostic significance in advanced stage marginal zone lymphoma patients treated with rituximab, cyclophosphamide, vincristine, and prednisone combination chemotherapy (R-CVP): Consortium for Improvi
    Jeongkuk Seo, Won Seog Kim, Jin Seok Kim, Seok Jin Kim, Jae Hoon Lee, Jun Shik Hong, Gyeong-Won Lee, Sung Yong Oh, Ji-Hyun Lee, Dok Hyun Yoon, Won-Sik Lee, Hyo Jung Kim, Jae-Yong Kwak, Hye Jin Kang, Jae-Cheol Jo, Yong Park, Ho Sup Lee, Hyo-Jin Kim, Cheolw
    Blood Research.2017; 52(3): 200.     CrossRef
  • Treatment outcome and risk analysis for cataract after radiotherapy of localized ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphoma
    Hee Hyun Park, Sea-Won Lee, Soo Yoon Sung, Byung Ock Choi
    Radiation Oncology Journal.2017; 35(3): 249.     CrossRef
  • The prognostic significance of CD11b+CX3CR1+ monocytes in patients with newly diagnosed diffuse large B-cell lymphoma
    Ho-Young Yhim, Jeong-A Kim, Sun-Hye Ko, Youngrok Park, Eunjung Yim, Hee Sun Kim, Jae-Yong Kwak
    Oncotarget.2017; 8(54): 92289.     CrossRef
  • Epidural Lymphoma Mimicking Hematoma: A Case Report
    Dong-Yeong Lee, Soon-Taek Jeong, Kun-Tae Kim, Jung-Wook Yang, Dong-Hee Kim
    Journal of Korean Society of Spine Surgery.2017; 24(1): 49.     CrossRef
  • A phase II study of oxaliplatin and prednisone for patients with relapsed or refractory marginal zone lymphoma: Consortium for Improving Survival of Lymphoma trial
    Sung Yong Oh, Won Seog Kim, Jin Seok Kim, Yee Soo Chae, Gyeong-Won Lee, Hyeon Seok Eom, Hun Mo Ryoo, Suee Lee, Seok Jin Kim, Dok Hyun Yoon, Jong Ho Won, Junshik Hong, Jinny Park, Sang-Min Lee, Jung Yong Hong, Eunkyung Park, Hyo Jung Kim, Deok-Hwan Yang, H
    Leukemia & Lymphoma.2016; 57(6): 1406.     CrossRef
  • Diffuse Large B-Cell Lymphoma of the Peri-Implant Mucosa Mimicking Peri-Implantitis
    Seong-Ho Jin, Gyeongsin Park, Youngkyung Ko, Jun-Beom Park
    Journal of Oral Implantology.2016; 42(2): 220.     CrossRef
  • The Roles of Radiotherapy and Chemotherapy in the Era of Multimodal Treatment for Early-Stage Nasal-Type Extranodal Natural Killer/T-Cell Lymphoma
    Tae Hyung Kim, Jin Seok Kim, Yang-Gun Suh, Jaeho Cho, Woo-Ick Yang, Chang-Ok Suh
    Yonsei Medical Journal.2016; 57(4): 846.     CrossRef
  • Treatment outcomes of IMEP as a front-line chemotherapy for patients with peripheral T-cell lymphomas
    Ji Young Lee, Sang Min Lee, Moon Young Choi, Ki Hyang Kim, Young Don Joo, Sung Nam Im, Won Sik Lee
    Blood Research.2016; 51(3): 187.     CrossRef
  • Immune reconstitution inflammatory syndrome versus non-immune reconstitution inflammatory syndrome lymphoma in HIV patients on antiretroviral therapy
    Pyoeng Gyun Choe, Jinyong Park, Wan Beom Park, Tae Min Kim, Kyoung-Ho Song, Ji Hwan Bang, Eu Suk Kim, Sang Won Park, Hong Bin Kim, Nam Joong Kim, Myoung-don Oh, Kang Won Choe
    International Journal of STD & AIDS.2016; 27(11): 1013.     CrossRef
  • Clinical outcome and prognosis of patients with primary sinonasal tract diffuse large B-cell lymphoma treated with rituximab-cyclophosphamide, doxorubicin, vincristine and prednisone chemotherapy: a study by the Consortium for Improving Survival of Lympho
    Gyeong-Won Lee, Se-Il Go, Seok-Hyun Kim, Junshik Hong, Yu Ri Kim, Sukjoong Oh, Sung-Yong Kim, Young Rok Do, Hyewon Lee, Soon Il Lee, Sung Hwa Bae, Sung Yong Oh, Moo Kon Song, Won-Sik Lee, Bohee Lee, Jin Seok Kim, Min Kyoung Kim, Hye Jin Kang, Jae-Sook Ahn
    Leukemia & Lymphoma.2015; 56(4): 1020.     CrossRef
  • Therapeutic comparison of Surgery combined with chemotherapy and chemotherapy alone for Primary Gastrointestinal Lymphoma: A single center study
    Je Hun Kim, Ho Sup Lee, Jun Seop Lee, Jin Young Lee, Su Young Kim, Cheol Su Kim, Joung Wook Yang, Ga In You
    Kosin Medical Journal.2015; 30(1): 29.     CrossRef
  • A Case of Simultaneous Primary Gastric and Duodenal Mucosa-Associated Lymphoid Tissue Lymphoma after Therapeutic Endoscopy
    Sun Hee Park, Jae Young Jang, Min A Park, Hyuck Kim, Young Woon Chang
    Korean Journal of Medicine.2015; 89(1): 64.     CrossRef
  • Clinicopathologic Study of Chromosomal Aberrations in Ocular Adnexal Lymphomas of Korean Patients
    Hokyung Choung, Young A Kim, Namju Kim, Min Joung Lee, Sang In Khwarg
    Korean Journal of Ophthalmology.2015; 29(5): 285.     CrossRef
  • A Rare Case of Malignant Lymphoma Occurred at Spinal Epidural Space: A Case Report
    Hyun-Jun Cho, Jang-Bo Lee, Junseok W. Hur, Sung-Won Jin, Tai-Hyoung Cho, Jung-Yul Park
    Korean Journal of Spine.2015; 12(3): 177.     CrossRef
  • Radiotherapy as an effective treatment modality for follicular lymphoma: a single institution experience
    Seo Hee Choi, Jaeho Cho, Jin Seok Kim, June-Won Cheong, Chang-Ok Suh
    Radiation Oncology Journal.2015; 33(4): 310.     CrossRef
  • Current therapy of choice for cutaneous lymphomas: Complementary to the Japanese Dermatological Association/Japanese Skin Cancer Society guidelines
    Keiji Iwatsuki, Toshihisa Hamada
    The Journal of Dermatology.2014; 41(1): 43.     CrossRef
  • The Role of Radiotherapy in the Treatment of Gastric Mucosa-Associated Lymphoid Tissue Lymphoma
    Taek-Keun Nam, Jae-Sook Ahn, Yoo-Duk Choi, Jae-Uk Jeong, Yong-Hyeob Kim, Mee Sun Yoon, Ju-Young Song, Sung-Ja Ahn, Woong-Ki Chung
    Cancer Research and Treatment.2014; 46(1): 33.     CrossRef
  • Current Concepts in Primary Effusion Lymphoma and Other Effusion-Based Lymphomas
    Yoonjung Kim, Chan Jeong Park, Jin Roh, Jooryung Huh
    Korean Journal of Pathology.2014; 48(2): 81.     CrossRef
  • Benign Indolent CD56-Positive NK-Cell Lymphoproliferative Lesion Involving Gastrointestinal Tract in an Adolescent
    Jaemoon Koh, Heounjeong Go, Won Ae Lee, Yoon Kyung Jeon
    Korean Journal of Pathology.2014; 48(1): 73.     CrossRef
  • Peripheral T cell lymphoma in Asia
    Sanghui Park, Young Hyeh Ko
    International Journal of Hematology.2014; 99(3): 227.     CrossRef
  • Characteristics of Cutaneous Lymphomas in Korea According to the New WHO-EORTC Classification: Report of a Nationwide Study
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    Korean Journal of Pathology.2014; 48(2): 126.     CrossRef
  • Epstein–Barr virus‐associated T/natural killer‐cell lymphoproliferative disorders
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  • Overexpression of sphingosine-1-phosphate receptor 1 and phospho-signal transducer and activator of transcription 3 is associated with poor prognosis in rituximab-treated diffuse large B-cell lymphomas
    Jin Ho Paik, Soo Jeong Nam, Tae Min Kim, Dae Seog Heo, Chul-Woo Kim, Yoon Kyung Jeon
    BMC Cancer.2014;[Epub]     CrossRef
  • Clinicopathologic implication of A20/TNFAIP3 deletion in diffuse large B-cell lymphoma: an analysis according to immunohistochemical subgroups and rituximab treatment
    Jin Ho Paik, Heounjeong Go, Soo Jeong Nam, Tae Min Kim, Dae Seog Heo, Chul-Woo Kim, Yoon Kyung Jeon
    Leukemia & Lymphoma.2013; 54(9): 1934.     CrossRef
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    Blood Research.2013; 48(2): 115.     CrossRef
  • Epidemiologic overview of malignant lymphoma
    Jooryung Huh
    The Korean Journal of Hematology.2012; 47(2): 92.     CrossRef
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    Korean Journal of Medicine.2012; 83(2): 263.     CrossRef
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    Korean Journal of Medicine.2012; 83(6): 712.     CrossRef
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    Korean Journal of Medicine.2012; 83(6): 689.     CrossRef
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    The Korean Journal of Pathology.2011; 45(6): 589.     CrossRef
Accuracy of Core Needle Biopsy Versus Fine Needle Aspiration Cytology for Diagnosing Salivary Gland Tumors
In Hye Song, Joon Seon Song, Chang Ohk Sung, Jong-Lyel Roh, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim, Jeong Hyun Lee, Jung Hwan Baek, Kyung-Ja Cho
J Pathol Transl Med. 2015;49(2):136-143.   Published online March 12, 2015
DOI: https://doi.org/10.4132/jptm.2015.01.03
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AbstractAbstract PDF
Background
Core needle biopsy is a relatively new technique used to diagnose salivary gland lesions, and its role in comparison with fine needle aspiration cytology needs to be refined. Methods: We compared the results of 228 ultrasound-guided core needle biopsy and 371 fine needle aspiration procedures performed on major salivary gland tumors with their postoperative histological diagnoses. Results: Core needle biopsy resulted in significantly higher sensitivity and more accurate tumor subtyping, especially for malignant tumors, than fine needle aspiration. No patient developed major complications after core needle biopsy. Conclusions: We recommend ultrasoundguided core needle biopsy as the primary diagnostic tool for the preoperative evaluation of patients with salivary gland lesions, especially when malignancy is suspected.

Citations

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  • Giant Pleomorphic Adenoma of Submandibular Gland
    Harendra Kumar, Qazi Saquib Rizwan, Mayank Gupta, Tarun Kumar
    Indian Journal of Otolaryngology and Head & Neck Surgery.2024; 76(1): 1361.     CrossRef
  • CT-guided core needle biopsies of head and neck tumors: a comprehensive monocenter analysis of safety and outcomes
    Thomas Joseph Vogl, Heinrich Johannes Ketelsen, Scherwin Mahmoudi, Jan-Erik Scholtz, Vitali Koch, Leon David Grünewald, Peter Wild, Timo Stoever, Simon Bernatz
    European Radiology.2024;[Epub]     CrossRef
  • Indications for Submandibulectomy Within a 20-Year Period
    Amir Bolooki, Anna Stenzl, Christopher Weusthof, Benedikt Hofauer
    Ear, Nose & Throat Journal.2024;[Epub]     CrossRef
  • The Usefulness of Ultrasound-Guided Core Needle Biopsy Compared to Fine Needle Aspiration in Pre-Operative Diagnosis of Cystic-Predominant Parotid Tumors
    Youn Jin Cho, Young Rok Jo, Hyun Jun Hong, Hye Ran Lee
    Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2023; 66(8): 532.     CrossRef
  • The Value of Ultrasound-guided Core Needle Biopsy in Differentiating Benign from Malignant Salivary Gland Lesions
    Mohammad Ali Kazemi, Farzaneh Amini, Bita Kargar, Maryam Lotfi, Keyvan Aghazadeh, Hashem Sharifian, Behnaz Moradi, Javid Azadbakht
    Indian Journal of Otolaryngology and Head & Neck Surgery.2023; 75(2): 266.     CrossRef
  • Schnellschnittdiagnostik bei Tumoren des Trigonum submandibulare
    S. Riemann, A. Knopf
    HNO.2023; 71(3): 164.     CrossRef
  • Myoepithelial Carcinoma Ex Pleomorphic Adenoma of the Submandibular Gland: A Case Report
    Georgia Syrnioti, Antonia Syrnioti, Alharith Abdullah, Xuehui Lui, Ernesto Mendoza
    Cureus.2023;[Epub]     CrossRef
  • Intraductal Carcinoma: The Carcinoma In Situ of the Salivary Gland
    Rhema Thomas, Tijjani Umar, Farzad Borumandi
    Journal of Craniofacial Surgery.2023; 34(5): e432.     CrossRef
  • Fine-Needle Aspiration Cytology for Parotid Tumors
    Masataka Taniuchi, Tetsuya Terada, Ryo Kawata
    Life.2022; 12(11): 1897.     CrossRef
  • Utility of the Milan System for Reporting Salivary Gland Cytology, with focus on the incidence and histologic correlates of atypia of undetermined significance (AUS) and salivary gland neoplasm of uncertain malignant potential (SUMP): A 3‐year institution
    Christopher M. Cormier, Shweta Agarwal
    Cancer Cytopathology.2022; 130(4): 303.     CrossRef
  • Percutaneous CT-Guided Core Needle Biopsies of Head and Neck Masses: Review of 184 Cases at a Single Academic Institution, Common and Special Techniques, Diagnostic Yield, and Safety
    R.W. Jordan, D.P. Shlapak, J.C. Benson, F.E. Diehn, D.K. Kim, V.T. Lehman, G.B. Liebo, A.A. Madhavan, J.M. Morris, P.P. Morris, J.T. Verdoorn, C.M. Carr
    American Journal of Neuroradiology.2022; 43(1): 117.     CrossRef
  • Nodular fasciitis of the submandibular gland
    Ting Suen Wong, Richard Wei Chern Gan, Laszlo Karsai, Bun Yin Winson Wong
    BMJ Case Reports.2022; 15(4): e245584.     CrossRef
  • Validation of the Milan system for reporting salivary gland cytopathology: a single institution’s 10-year experience
    Christopher Felicelli, Joseph Reznicek, Yevgen Chornenkyy, Lucy Jager, Daniel Johnson
    Journal of the American Society of Cytopathology.2022; 11(5): 264.     CrossRef
  • Application of the Milan system for reporting salivary gland cytopathology using cell blocks
    Grégoire B. Morand, Raihanah Alsayegh, Alex M. Mlynarek, Marianne Plourde, Tiffany Mach, Marco A. Mascarella, Michael P. Hier, Livia Florianova, Marc P. Pusztaszeri
    Virchows Archiv.2022; 481(4): 575.     CrossRef
  • Comparisons among the Ultrasonography Prediction Model, Real-Time and Shear Wave Elastography in the Evaluation of Major Salivary Gland Tumors
    Ping-Chia Cheng, Wu-Chia Lo, Chih-Ming Chang, Ming-Hsun Wen, Po-Wen Cheng, Li-Jen Liao
    Diagnostics.2022; 12(10): 2488.     CrossRef
  • A Novel Sonographic Scoring Model in the Prediction of Major Salivary Gland Tumors
    Wu‐Chia Lo, Chih‐Ming Chang, Chi‐Te Wang, Po‐Wen Cheng, Li‐Jen Liao
    The Laryngoscope.2021;[Epub]     CrossRef
  • Assessing the diagnostic accuracy for pleomorphic adenoma and Warthin tumor by employing the Milan System for Reporting Salivary Gland Cytopathology: An international, multi‐institutional study
    Derek B. Allison, Alexander P. Smith, Daniel An, James Adam Miller, Khurram Shafique, Sharon Song, Kartik Viswanathan, Elizabeth Eykman, Rema A. Rao, Austin Wiles, Güliz A. Barkan, Ritu Nayar, Guido Fadda, Celeste N. Powers, Esther Diana Rossi, Momin T. S
    Cancer Cytopathology.2021; 129(1): 43.     CrossRef
  • Magnetic resonance imaging of salivary gland tumours: Key findings for imaging characterisation
    Davide Maraghelli, Michele Pietragalla, Cesare Cordopatri, Cosimo Nardi, Anna Julie Peired, Giandomenico Maggiore, Stefano Colagrande
    European Journal of Radiology.2021; 139: 109716.     CrossRef
  • The Milan System, from Its Introduction to Its Current Adoption in the Diagnosis of Salivary Gland Cytology
    Esther Diana Rossi
    Journal of Molecular Pathology.2021; 2(2): 114.     CrossRef
  • Utility of the Milan system for reporting salivary gland cytopathology during rapid on‐site evaluation (ROSE) of salivary gland aspirates
    Aanchal Kakkar, Mukin Kumar, Priyadarsani Subramanian, Arshad Zubair, Rajeev Kumar, Alok Thakar, Deepali Jain, Sandeep R. Mathur, Venkateswaran K. Iyer
    Cytopathology.2021; 32(6): 779.     CrossRef
  • Contribution of small tissue biopsy and flow cytometry to preoperative cytological categorization of salivary gland fine needle aspirates according to the Milan System: Single center experience on 287 cases
    Tolga Bağlan, Serpil Dizbay Sak, Cevriye Cansız Ersöz, Koray Ceyhan
    Diagnostic Cytopathology.2021; 49(4): 509.     CrossRef
  • Is Milan for kids?: The Milan System for Reporting Salivary Gland Cytology in pediatric patients at an academic children's hospital with cytologic‐histologic correlation
    Swati P. Satturwar, Maren Y. Fuller, Sara E. Monaco
    Cancer Cytopathology.2021; 129(11): 884.     CrossRef
  • Radiographic Interpretation in Oral Medicine and Hospital Dental Practice
    Katherine France, Anwar A.A.Y. AlMuzaini, Mel Mupparapu
    Dental Clinics of North America.2021; 65(3): 509.     CrossRef
  • Carcinoma ex pleomorphic adenoma of major salivary glands: CT and MR imaging findings
    Can Wang, Qiang Yu, Siyi Li, Jingjing Sun, Ling Zhu, Pingzhong Wang
    Dentomaxillofacial Radiology.2021; 50(7): 20200485.     CrossRef
  • Salivary gland carcinoma in children and adolescents: The EXPeRT/PARTNER diagnosis and treatment recommendations
    Aurore Surun, Dominik T. Schneider, Andrea Ferrari, Teresa Stachowicz‐Stencel, Jelena Rascon, Anna Synakiewicz, Abbas Agaimy, Kata Martinova, Denis Kachanov, Jelena Roganovic, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Frédéric Kolb, Juliette Thariat, Anto
    Pediatric Blood & Cancer.2021;[Epub]     CrossRef
  • A Call for Universal Acceptance of the Milan System for Reporting Salivary Gland Cytopathology
    Eric Barbarite, Sidharth V. Puram, Adeeb Derakhshan, Esther D. Rossi, William C. Faquin, Mark A. Varvares
    The Laryngoscope.2020; 130(1): 80.     CrossRef
  • Preoperative biopsy in parotid malignancies: Variation in use and impact on surgical margins
    Liliya Benchetrit, Sina J. Torabi, Elliot Morse, Saral Mehra, Rahmatullah Rahmati, Heather A. Osborn, Benjamin L. Judson
    The Laryngoscope.2020; 130(6): 1450.     CrossRef
  • α‐Synuclein Real‐Time Quaking‐Induced Conversion in the Submandibular Glands of Parkinson's Disease Patients
    Sireesha Manne, Naveen Kondru, Huajun Jin, Vellareddy Anantharam, Xuemei Huang, Arthi Kanthasamy, Anumantha G. Kanthasamy
    Movement Disorders.2020; 35(2): 268.     CrossRef
  • The Accessory Parotid Gland and its Clinical Significance
    Mateusz A. Rosa, Dominik P. Łazarz, Jakub R. Pękala, Bendik Skinningsrud, Sigurd S. Lauritzen, Bernard Solewski, Przemysław A. Pękala, Jerzy A. Walocha, Krzysztof A. Tomaszewski
    Journal of Craniofacial Surgery.2020; 31(3): 856.     CrossRef
  • Comparison of core needle biopsy and fine‐needle aspiration in diagnosis of ma lignant salivary gland neoplasm: Systematic review and meta‐analysis
    Jungheum Cho, Junghoon Kim, Ji Sung Lee, Choong Guen Chee, Youngjune Kim, Sang Il Choi
    Head & Neck.2020; 42(10): 3041.     CrossRef
  • The Milan system for reporting salivary gland cytopathology: The clinical impact so far. Considerations from theory to practice
    Esther Diana Rossi, William C. Faquin
    Cytopathology.2020; 31(3): 181.     CrossRef
  • The role of core needle biopsy in parotid glands lesions with inconclusive fine needle aspiration
    Farrokh Heidari, Firouzeh Heidari, Benyamin Rahmaty, Neda Jafari, Kayvan Aghazadeh, Saeed Sohrabpour, Ebrahim Karimi
    American Journal of Otolaryngology.2020; 41(6): 102718.     CrossRef
  • Role of Fine Needle Aspiration Cytology in the Diagnosis of Parotid Gland Tumors: Analysis of 193 Cases
    Rahim Dhanani, Haissan Iftikhar, Muhammad Sohail Awan, Nida Zahid, Sehrish Nizar Ali Momin
    International Archives of Otorhinolaryngology.2020; 24(04): e508.     CrossRef
  • Cytohistological correlation of salivary gland tumours with emphasis on Milan system for reporting: A novel step towards internal quality assurance
    Anandraj Vaithy.K, ATM Venkat Raghava, E S Keerthika Sri, K R Umadevi
    IP Archives of Cytology and Histopathology Research.2020; 5(4): 283.     CrossRef
  • Diagnosing Recently Defined and Uncommon Salivary Gland Lesions in Limited Cellularity Specimens: Cytomorphology and Ancillary Studies
    Esther Diana Rossi, Zubair Baloch, William Faquin, Liron Pantanowitz
    AJSP: Reviews and Reports.2020; 25(5): 210.     CrossRef
  • Peripheral T Cell Lymphoma of Parotid Gland: A Diagnostic Challenge
    J. G. Aishwarya, Satish Nair, C. N. Patil, Swarna Shivakumar, N. Shrivalli, Ashish Shah
    Indian Journal of Otolaryngology and Head & Neck Surgery.2019; 71(S1): 533.     CrossRef
  • Potential utility of core needle biopsy in the diagnosis of IgG4-related dacryoadenitis and sialadenitis
    Kenichi Takano, Tsuyoshi Okuni, Keisuke Yamamoto, Ryuta Kamekura, Ryoto Yajima, Motohisa Yamamoto, Hiroki Takahashi, Tetsuo Himi
    Modern Rheumatology.2019; 29(2): 393.     CrossRef
  • Retrospective assessment of the effectiveness of the Milan system for reporting salivary gland cytology: A systematic review and meta‐analysis of published literature
    Sahar J Farahani, Zubair Baloch
    Diagnostic Cytopathology.2019; 47(2): 67.     CrossRef
  • Values of fine‐needle aspiration cytology of parotid gland tumors: A review of 996 cases at a single institution
    Manabu Suzuki, Ryo Kawata, Masaaki Higashino, Shuji Nishikawa, Tetsuya Terada, Shin‐Ichi Haginomori, Yoshitaka Kurisu, Yoshinobu Hirose
    Head & Neck.2019; 41(2): 358.     CrossRef
  • Positive Surgical Margins in Submandibular Malignancies: Facility and Practice Variation
    Liliya Benchetrit, Elliot Morse, Benjamin L. Judson, Saral Mehra
    Otolaryngology–Head and Neck Surgery.2019; 161(4): 620.     CrossRef
  • The growth rate and the positive prediction of needle biopsy of clinically diagnosed Warthin’s tumor
    Jungirl Seok, Woo-Jin Jeong, Soon-Hyun Ahn, Young Ho Jung
    European Archives of Oto-Rhino-Laryngology.2019; 276(7): 2091.     CrossRef
  • The Difference in the Clinical Features Between Carcinoma ex Pleomorphic Adenoma and Pleomorphic Adenoma
    Jungirl Seok, Se Jin Hyun, Woo-Jin Jeong, Soon-Hyun Ahn, Hyojin Kim, Young Ho Jung
    Ear, Nose & Throat Journal.2019; 98(8): 504.     CrossRef
  • Fine‐needle aspiration cytology and radiological imaging in parotid gland tumours: Our experience in 103 patients
    Clare Perkins, Edward Toll, Philip Reece
    Clinical Otolaryngology.2019; 44(6): 1124.     CrossRef
  • Ultrasound‐guided core needle biopsy in salivary glands: A meta‐analysis
    Hee Joon Kim, Jong Seung Kim
    The Laryngoscope.2018; 128(1): 118.     CrossRef
  • Accuracy and effectiveness of ultrasound-guided core-needle biopsy in the diagnosis of focal lesions in the salivary glands
    Jose Luis del Cura, Gloria Coronado, Rosa Zabala, Igone Korta, Ignacio López
    European Radiology.2018; 28(7): 2934.     CrossRef
  • The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC): an ASC-IAC–sponsored system for reporting salivary gland fine-needle aspiration
    Esther Diana Rossi, Zubair Baloch, Marc Pusztaszeri, William C. Faquin
    Journal of the American Society of Cytopathology.2018; 7(3): 111.     CrossRef
  • Routine and Advanced Ultrasound of Major Salivary Glands
    Kunwar Suryaveer Singh Bhatia, Yuk-Ling Dai
    Neuroimaging Clinics of North America.2018; 28(2): 273.     CrossRef
  • The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC): An ASC-IAC-Sponsored System for Reporting Salivary Gland Fine-Needle Aspiration
    Esther Diana Rossi, Zubair W. Baloch, Marc Pusztaszeri, William C. Faquin
    Acta Cytologica.2018; 62(3): 157.     CrossRef
  • Evaluation and diagnosis of salivary gland neoplasms
    Erica Jackson Mayland, Anna M. Pou
    Operative Techniques in Otolaryngology-Head and Neck Surgery.2018; 29(3): 129.     CrossRef
  • Feasibility and Safety of Multicenter Tissue and Biofluid Sampling for α-Synuclein in Parkinson’s Disease: The Systemic Synuclein Sampling Study (S4)
    Lana M. Chahine, Thomas G. Beach, Nicholas Seedorff, Chelsea Caspell-Garcia, Christopher S. Coffey, Michael Brumm, Charles H. Adler, Geidy E. Serrano, Carly Linder, Sherri Mosovsky, Tatiana Foroud, Holly Riss, Dixie Ecklund, John Seibyl, Danna Jennings, V
    Journal of Parkinson's Disease.2018; 8(4): 517.     CrossRef
  • Preoperative diagnostic of parotid gland neoplasms: fine-needle aspiration cytology or core needle biopsy?
    Peter Zbären, Asterios Triantafyllou, Kenneth O. Devaney, Vincent Vander Poorten, Henrik Hellquist, Alessandra Rinaldo, Alfio Ferlito
    European Archives of Oto-Rhino-Laryngology.2018; 275(11): 2609.     CrossRef
  • A comparison study of the reporting systems for salivary gland fine needle aspirations: Are they really different?
    Diana Montezuma, Sule Canberk, Ozlem Aydın, Mehmet Polat Dermirhas, André F. Vieira, Süha Goksel, Ümit İnce, Fernando Schmitt
    Diagnostic Cytopathology.2018; 46(10): 859.     CrossRef
  • Pediatric salivary gland carcinomas: Diagnostic and therapeutic management
    Céleste Rebours, Vincent Couloigner, Louise Galmiche, Odile Casiraghi, Cécile Badoual, Sabah Boudjemaa, Anthony Chauvin, Monique Elmaleh, Brice Fresneau, Sylvie Fasola, Erea‐Noël Garabédian, Thierry Van Den Abeele, Daniel Orbach
    The Laryngoscope.2017; 127(1): 140.     CrossRef
  • Agreement between rapid on‐site evaluation and the final cytological diagnosis of salivary gland specimens
    S. Wangsiricharoen, S. Lekawanvijit, S. Rangdaeng
    Cytopathology.2017; 28(4): 321.     CrossRef
  • Mesenchymal neoplasms of the head and neck: a cytopathologic analysis on fine needle aspiration
    James Lee, Samia Kazmi, Christopher J. VandenBussche, Syed Z. Ali
    Journal of the American Society of Cytopathology.2017; 6(3): 105.     CrossRef
  • Clinical Results of Surgical Treatment in Parotid Tumors
    Ahmet Kara
    Journal of Otolaryngology-ENT Research.2017;[Epub]     CrossRef
  • Parotid gland metastases of distant primary tumours: A diagnostic challenge
    Achim M. Franzen, Thomas Günzel, Anja Lieder
    Auris Nasus Larynx.2016; 43(2): 187.     CrossRef
  • Modern Radiology in the Management of Head and Neck Cancer
    G.J.C. Burkill, R.M. Evans, V.V. Raman, S.E.J. Connor
    Clinical Oncology.2016; 28(7): 440.     CrossRef
  • Fine‐needle aspiration and core needle biopsy: An update on 2 common minimally invasive tissue sampling modalities
    Paul A. VanderLaan
    Cancer Cytopathology.2016; 124(12): 862.     CrossRef
  • Staging and follow-up of high-grade malignant salivary gland tumours: The role of traditional versus functional imaging approaches – A review
    Nicole Freling, Flavio Crippa, Roberto Maroldi
    Oral Oncology.2016; 60: 157.     CrossRef
  • Biopsy of parotid masses: Review of current techniques
    Sananda Haldar, Joseph D Sinnott, Kemal M Tekeli, Samuel S Turner, David C Howlett
    World Journal of Radiology.2016; 8(5): 501.     CrossRef
  • Review on the applications of ultrasonography in dentomaxillofacial region
    Şehrazat Evirgen
    World Journal of Radiology.2016; 8(1): 50.     CrossRef
  • Comprehensive Cytomorphologic Analysis of Pulmonary Adenoid Cystic Carcinoma: Comparison to Small Cell Carcinoma and Non-pulmonary Adenoid Cystic Carcinoma
    Seokhwi Kim, Jinah Chu, Hojoong Kim, Joungho Han
    Journal of Pathology and Translational Medicine.2015; 49(6): 511.     CrossRef
Microsatellite Instability Status in Gastric Cancer: A Reappraisal of Its Clinical Significance and Relationship with Mucin Phenotypes
Joo-Yeun Kim, Na Ri Shin, Ahrong Kim, Hyun-Jeong Lee, Won-young Park, Jee-Yeon Kim, Chang-Hun Lee, Gi-Young Huh, Do Youn Park
Korean J Pathol. 2013;47(1):28-35.   Published online February 25, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.1.28
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AbstractAbstract PDF
Background

Gastric cancers with microsatellite instabilities (MSI) have been reported to be associated with favorable prognosis. However, the significance of the effect of MSI on the clinicopathological features, as well as its association with mucin phenotype, remains unclear.

Methods

MSI status was assessed in 414 cases of gastric cancer using polymerase chain reaction analysis of five microsatellite loci, as recommended by National Cancer Institution criteria. The expression of mucins (MUC5AC, MUC6, MUC2, and CD10) was assessed.

Results

Out of 414 total cases of gastric cancer, 380 (91.7%), 11 (2.7%), and 23 (5.6%) were microsatellite stable (MSS), low-level MSI (MSI-L), and high-level MSI (MSI-H), respectively. Compared to MSS/MSI-L, MSI-H gastric cancers were associated with older age (p=0.010), tumor size (p=0.014), excavated gross (p=0.042), intestinal type (p=0.028), aggressive behaviors (increase of T stage [p=0.009]), perineural invasion [p=0.022], and lymphovascular emboli [p=0.027]). MSI-H gastric cancers were associated with tumor necrosis (p=0.041), tumor-infiltrating lymphocytes (≥2/high power field, p<0.001), expanding growth patterns (p=0.038), gastric predominant mucin phenotypes (p=0.028), and MUC6 expression (p=0.016). Tumor necrosis (≥10% of mass, p=0.031), tumor-infiltrating lymphocytes (p<0.001), intestinal type (p=0.014), and gastric mucin phenotypes (p=0.020) could represent independent features associated with MSI-H gastric cancers. MSI-H intestinal type gastric cancers had a tendency for poor prognosis in univariate analysis (p=0.054) but no association in Cox multivariate analysis (p=0.197).

Conclusions

Our data suggest that MSI-H gastric cancers exhibit distinct aggressive biologic behaviors and a gastric mucin phenotype. This contradicts previous reports that describe MSI-H gastric cancer as being associated with favorable prognosis.

Citations

Citations to this article as recorded by  
  • Non–Pure Intestinal Phenotype as an Indicator of Progression in Sporadic Nonampullary Duodenal Adenomas: A Multicenter Retrospective Cohort Study
    Ryotaro Uema, Yoshito Hayashi, Masato Komori, Narihiro Shibukawa, Noriko Hayashi, Masayoshi Horimoto, Takuya Yamada, Masashi Yamamoto, Satoshi Hiyama, Kazuo Kinoshita, Hideharu Ogiyama, Shinjiro Yamaguchi, Satoshi Egawa, Takashi Kanesaka, Minoru Kato, Shu
    Clinical and Translational Gastroenterology.2024; 15(1): e00649.     CrossRef
  • Intratumoral and peritumoral CT-based radiomics for predicting the microsatellite instability in gastric cancer
    Xingchi Chen, Zijian Zhuang, Lin Pen, Jing Xue, Haitao Zhu, Lirong Zhang, Dongqing Wang
    Abdominal Radiology.2024;[Epub]     CrossRef
  • Deep learning captures selective features for discrimination of microsatellite instability from pathologic tissue slides of gastric cancer
    Sung Hak Lee, Yujin Lee, Hyun‐Jong Jang
    International Journal of Cancer.2023; 152(2): 298.     CrossRef
  • Novel Biomarkers of Gastric Cancer: Current Research and Future Perspectives
    Yasushi Sato, Koichi Okamoto, Yutaka Kawano, Akinari Kasai, Tomoyuki Kawaguchi, Tamotsu Sagawa, Masahiro Sogabe, Hiroshi Miyamoto, Tetsuji Takayama
    Journal of Clinical Medicine.2023; 12(14): 4646.     CrossRef
  • The results of treatment for resectable gastric cancer with microsatellite instability
    H. Sun, S. N. Nered, A. A. Tryakin, E. V. Artamonova, A. E. Kalinin, V. E. Bugaev, A. M. Stroganova, N. S. Besova, P. P. Arkhiri, V. I. Marshall, R. Sh. Abdulaeva, I. S. Stilidi
    Pelvic Surgery and Oncology.2023; 13(2): 17.     CrossRef
  • Heterogeneity and Adjuvant Therapeutic Approaches in MSI-H/dMMR Resectable Gastric Cancer: Emerging Trends in Immunotherapy
    Hui Wu, Wenyuan Ma, Congfa Jiang, Ning Li, Xin Xu, Yongfeng Ding, Haiping Jiang
    Annals of Surgical Oncology.2023; 30(13): 8572.     CrossRef
  • Dual-layer spectral-detector CT for predicting microsatellite instability status and prognosis in locally advanced gastric cancer
    Yongjian Zhu, Peng Wang, Bingzhi Wang, Zhichao Jiang, Ying Li, Jun Jiang, Yuxin Zhong, Liyan Xue, Liming Jiang
    Insights into Imaging.2023;[Epub]     CrossRef
  • Concordance between microsatellite instability testing and immunohistochemistry for mismatch repair proteins and efficient screening of mismatch repair deficient gastric cancer
    Gou Yamamoto, Tetsuya Ito, Okihide Suzuki, Nao Kamae, Miho Kakuta, Akemi Takahashi, Katsuya Iuchi, Tomio Arai, Hideyuki Ishida, Kiwamu Akagi
    Oncology Letters.2023;[Epub]     CrossRef
  • Low incidence of microsatellite instability in gastric cancers and its association with the clinicopathological characteristics: a comparative study
    Fateme Fooladi Talari, Ali Bozorg, Sirous Zeinali, Mohammadreza Zali, Zhale Mohsenifar, Hamid Asadzadeh Aghdaei, Kaveh Baghaei
    Scientific Reports.2023;[Epub]     CrossRef
  • Mutational separation and clinical outcomes of TP53 and CDH1 in gastric cancer
    He-Li Liu, Huan Peng, Chang-Hao Huang, Hai-Yan Zhou, Jie Ge
    World Journal of Gastrointestinal Surgery.2023; 15(12): 2855.     CrossRef
  • Genomic and Immunologic Markers of Intrinsic Resistance to Pembrolizumab Monotherapy in Microsatellite Instability-High Gastric Cancer: Observations from a Prospective Phase II Study
    Haibo Qiu
    Global Medical Genetics.2022; 09(02): 060.     CrossRef
  • Clinicopathological features of PD-L1 protein expression, EBV positivity, and MSI status in patients with advanced gastric and esophagogastric junction adenocarcinoma in Japan
    Tsutomu Yoshida, Go Ogura, Mikiko Tanabe, Takuo Hayashi, Chiho Ohbayashi, Mizutomo Azuma, Chikara Kunisaki, Yoichi Akazawa, Soji Ozawa, Sohei Matsumoto, Takayoshi Suzuki, Akira Mitoro, Tetsu Fukunaga, Akiko Shimizu, Go Fujimoto, Takashi Yao
    Cancer Biology & Therapy.2022; 23(1): 191.     CrossRef
  • Development of Tissue-Agnostic Treatments for Patients with Cancer
    Steven Lemery, Lola Fashoyin-Aje, Leigh Marcus, Sandra Casak, Julie Schneider, Marc Theoret, Paul Kluetz, Richard Pazdur, Julia A. Beaver
    Annual Review of Cancer Biology.2022; 6(1): 147.     CrossRef
  • A multicenter study on the preoperative prediction of gastric cancer microsatellite instability status based on computed tomography radiomics
    Xiuqun Liang, Yinbo Wu, Ying Liu, Danping Yu, Chencui Huang, Zhi Li
    Abdominal Radiology.2022; 47(6): 2036.     CrossRef
  • Combination of AKT1 and CDH1 mutations predicts primary resistance to immunotherapy in dMMR/MSI-H gastrointestinal cancer
    Zhenghang Wang, Qi Zhang, Changsong Qi, Yuezong Bai, Feilong Zhao, Hui Chen, Zhongwu Li, Xicheng Wang, Mifen Chen, Jifang Gong, Zhi Peng, Xiaotian Zhang, Jinping Cai, Shiqing Chen, Xiaochen Zhao, Lin Shen, Jian Li
    Journal for ImmunoTherapy of Cancer.2022; 10(6): e004703.     CrossRef
  • Eldest gastric cancer patient with high microsatellite instability responding to pembrolizumab
    Akinobu Wakasugi, Akinori Sasaki, Risa Okamoto, Yasuaki Motomura
    International Cancer Conference Journal.2022; 12(1): 59.     CrossRef
  • Baseline lesion number as an efficacy predictive and independent prognostic factor and its joint utility with TMB for PD-1 inhibitor treatment in advanced gastric cancer
    Xiao-Li Wei, Jian-Ying Xu, De-Shen Wang, Dong-Liang Chen, Chao Ren, Jia-Ning Li, Feng Wang, Feng-Hua Wang, Rui-Hua Xu
    Therapeutic Advances in Medical Oncology.2021; 13: 175883592198899.     CrossRef
  • Clinical and morphological portrait of tumors with microsatellite instability
    A. A. Musaelyan, V. D. Nazarov, A. S. Budnikova, S. V. Lapin, S. L. Vorobyev, V. L. Emanuel, A. A. Zakharenko, S. V. Orlov
    Advances in Molecular Oncology.2021; 8(2): 52.     CrossRef
  • How to Best Exploit Immunotherapeutics in Advanced Gastric Cancer: Between Biomarkers and Novel Cell-Based Approaches
    Michele Ghidini, Angelica Petrillo, Andrea Botticelli, Dario Trapani, Alessandro Parisi, Anna La Salvia, Elham Sajjadi, Roberto Piciotti, Nicola Fusco, Shelize Khakoo
    Journal of Clinical Medicine.2021; 10(7): 1412.     CrossRef
  • Microsatellite instability in Gastric Cancer: Between lights and shadows
    Elisabetta Puliga, Simona Corso, Filippo Pietrantonio, Silvia Giordano
    Cancer Treatment Reviews.2021; 95: 102175.     CrossRef
  • Impact of microsatellite status on negative lymph node count and prognostic relevance after curative gastrectomy
    Zhenghao Cai, Junjun Ma, Shuchun Li, Abe Fingerhut, Jing Sun, Lu Zang, Chao Yan, Wentao Liu, Zhenggang Zhu, Minhua Zheng
    Journal of Surgical Oncology.2021;[Epub]     CrossRef
  • A greater lymph node yield is required during pathological examination in microsatellite instability-high gastric cancer
    Zhenghao Cai, Haiqin Song, Abe Fingerhut, Jing Sun, Junjun Ma, Luyang Zhang, Shuchun Li, Chaoran Yu, Minhua Zheng, Lu Zang
    BMC Cancer.2021;[Epub]     CrossRef
  • Determinants of Response and Intrinsic Resistance to PD-1 Blockade in Microsatellite Instability–High Gastric Cancer
    Minsuk Kwon, Minae An, Samuel J. Klempner, Hyuk Lee, Kyoung-Mee Kim, Jason K. Sa, Hee Jin Cho, Jung Yong Hong, Taehyang Lee, Yang Won Min, Tae Jun Kim, Byung-Hoon Min, Woong-Yang Park, Won Ki Kang, Kyu-Tae Kim, Seung Tae Kim, Jeeyun Lee
    Cancer Discovery.2021; 11(9): 2168.     CrossRef
  • Advanced Gastric Cancer: Current Treatment Landscape and a Future Outlook for Sequential and Personalized Guide: Swiss Expert Statement Article
    Alexander R. Siebenhüner, Sara De Dosso, Daniel Helbling, Christoforos Astaras, Petr Szturz, Peter Moosmann, Stefanie Pederiva, Thomas Winder, Philippe Von Burg, Markus Borner
    Oncology Research and Treatment.2021; 44(9): 485.     CrossRef
  • High homogeneity of mismatch repair deficiency in advanced prostate cancer
    Christoph Fraune, Ronald Simon, Doris Höflmayer, Katharina Möller, David Dum, Franziska Büscheck, Claudia Hube-Magg, Georgia Makrypidi-Fraune, Martina Kluth, Andrea Hinsch, Eike Burandt, Till Sebastian Clauditz, Waldemar Wilczak, Guido Sauter, Stefan Steu
    Virchows Archiv.2020; 476(5): 745.     CrossRef
  • High homogeneity of MMR deficiency in ovarian cancer
    Christoph Fraune, Janina Rosebrock, Ronald Simon, Claudia Hube-Magg, Georgia Makrypidi-Fraune, Martina Kluth, Franziska Büscheck, Doris Höflmayer, Barbara Schmalfeldt, Volkmar Müller, Linn Wölber, Isabell Witzel, Peter Paluchowski, Christian Wilke, Uwe He
    Gynecologic Oncology.2020; 156(3): 669.     CrossRef
  • Molecular Classification of Gastric Cancer among Alaska Native People
    Holly Martinson, Dominic Mallari, Christine Richter, Tsung-Teh Wu, James Tiesinga, Steven Alberts, Matthew Olnes
    Cancers.2020; 12(1): 198.     CrossRef
  • Tumor immune response and immunotherapy in gastric cancer
    Yoonjin Kwak, An Na Seo, Hee Eun Lee, Hye Seung Lee
    Journal of Pathology and Translational Medicine.2020; 54(1): 20.     CrossRef
  • MMR deficiency in urothelial carcinoma of the bladder presents with temporal and spatial homogeneity throughout the tumor mass
    Christoph Fraune, Ronald Simon, Claudia Hube-Magg, Georgia Makrypidi-Fraune, Christian Kähler, Martina Kluth, Doris Höflmayer, Franziska Büscheck, David Dum, Andreas M. Luebke, Eike Burandt, Till Sebastian Clauditz, Waldemar Wilczak, Guido Sauter, Stefan
    Urologic Oncology: Seminars and Original Investigations.2020; 38(5): 488.     CrossRef
  • MMR Deficiency is Homogeneous in Pancreatic Carcinoma and Associated with High Density of Cd8-Positive Lymphocytes
    Christoph Fraune, Eike Burandt, Ronald Simon, Claudia Hube-Magg, Georgia Makrypidi-Fraune, Martina Kluth, Franziska Büscheck, Doris Höflmayer, Niclas Ch. Blessin, Tim Mandelkow, Wenchao Li, Daniel Perez, Jakob R. Izbicki, Waldemar Wilczak, Guido Sauter, J
    Annals of Surgical Oncology.2020; 27(10): 3997.     CrossRef
  • CD73's Potential as an Immunotherapy Target in Gastrointestinal Cancers
    Jerry B. Harvey, Luan H. Phan, Oscar E. Villarreal, Jessica L. Bowser
    Frontiers in Immunology.2020;[Epub]     CrossRef
  • Tumor copy-number alterations predict response to immune-checkpoint-blockade in gastrointestinal cancer
    Zhihao Lu, Huan Chen, Shuang Li, Jifang Gong, Jian Li, Jianling Zou, Lihong Wu, Jianing Yu, Wenbo Han, Huaibo Sun, Xi Jiao, Xiaotian Zhang, Zhi Peng, Ming Lu, Zhenghang Wang, Henghui Zhang, Lin Shen
    Journal for ImmunoTherapy of Cancer.2020; 8(2): e000374.     CrossRef
  • Protein expression-based classification of gastric cancer by immunohistochemistry of tissue microarray
    Chong Zhao, Zhiqiang Feng, Hongzhen He, Dan Zang, Hong Du, Hongli Huang, Yanlei Du, Jie He, Yongjian Zhou, Yuqiang Nie, Girijesh Kumar Patel
    PLOS ONE.2020; 15(10): e0238836.     CrossRef
  • Clinicopathologic Characteristics and Long-Term Outcome of Gastric Cancer Patients with Family History: Seven-Year Follow-Up Study for Korean Health Check-Up Subjects
    Jooyoung Lee, Su Jin Chung, Ji Min Choi, Yoo Min Han, Joo Sung Kim, Greger Lindberg
    Gastroenterology Research and Practice.2020; 2020: 1.     CrossRef
  • Implication of expression of MMR proteins and clinicopathological characteristics in gastric cancer
    Renu Verma, Puja Sakhuja, Ritu Srivastava, Prakash Chand Sharma
    Asia-Pacific Journal of Oncology.2020; : 1.     CrossRef
  • Prognostic significance of microsatellite‐instability in gastric and gastroesophageal junction cancer patients undergoing neoadjuvant chemotherapy
    Georg Martin Haag, Elena Czink, Aysel Ahadova, Thomas Schmidt, Leila Sisic, Susanne Blank, Ulrike Heger, Leonidas Apostolidis, Anne Katrin Berger, Christoph Springfeld, Felix Lasitschka, Dirk Jäger, Magnus von Knebel Doeberitz, Matthias Kloor
    International Journal of Cancer.2019; 144(7): 1697.     CrossRef
  • Serological Markers Associated With Response to Immune Checkpoint Blockade in Metastatic Gastrointestinal Tract Cancer
    Zhihao Lu, Jianling Zou, Ying Hu, Shuang Li, Tao Zhou, Jifang Gong, Jian Li, Xiaotian Zhang, Jun Zhou, Ming Lu, Xicheng Wang, Zhi Peng, Changsong Qi, Yanyan Li, Jie Li, Yan Li, Jianyin Zou, Xiao Du, Henghui Zhang, Lin Shen
    JAMA Network Open.2019; 2(7): e197621.     CrossRef
  • Assessing molecular subtypes of gastric cancer: microsatellite unstable and Epstein-Barr virus subtypes. Methods for detection and clinical and pathological implications
    Carolina Martinez-Ciarpaglini, Tania Fleitas-Kanonnikoff, Valentina Gambardella, Marta Llorca, Cristina Mongort, Regina Mengual, Gema Nieto, Lara Navarro, Marisol Huerta, Susana Rosello, Desamparados Roda, Noelia Tarazona, Samuel Navarro, Gloria Ribas, An
    ESMO Open.2019; 4(3): e000470.     CrossRef
  • The role of pembrolizumab in the treatment of PD-L1 expressing gastric and gastroesophageal junction adenocarcinoma
    Gagandeep Brar, Manish A. Shah
    Therapeutic Advances in Gastroenterology.2019; 12: 175628481986976.     CrossRef
  • Novel Biomarkers for Prediction of Response to Preoperative Systemic Therapies in Gastric Cancer
    Alessandro Cavaliere, Valeria Merz, Simona Casalino, Camilla Zecchetto, Francesca Simionato, Hayley Louise Salt, Serena Contarelli, Raffaela Santoro, Davide Melisi
    Journal of Gastric Cancer.2019; 19(4): 375.     CrossRef
  • MICROSATELLITE INSTABILITY AND GASTRIC CARCINOMA. REVIEW OF THELITERATURE
    D. L. Rotin, O. V. Paklina, I. O. Tin’kova, D. N. Grekov
    Russian Journal of Biotherapy.2019; 18(4): 17.     CrossRef
  • Meta-analysis of microsatellite instability in relation to clinicopathological characteristics and overall survival in gastric cancer
    K Polom, L Marano, D Marrelli, R De Luca, G Roviello, V Savelli, P Tan, F Roviello
    British Journal of Surgery.2018; 105(3): 159.     CrossRef
  • Gastric poorly cohesive carcinoma: a correlative study of mutational signatures and prognostic significance based on histopathological subtypes
    Chae H Kwon, Young K Kim, Sojeong Lee, Ahrong Kim, Hye J Park, Yuri Choi, Yeo J Won, Do Y Park, Gregory Y Lauwers
    Histopathology.2018; 72(4): 556.     CrossRef
  • Microsatellite instability in gastric cancer: molecular bases, clinical perspectives, and new treatment approaches
    Margherita Ratti, Andrea Lampis, Jens C. Hahne, Rodolfo Passalacqua, Nicola Valeri
    Cellular and Molecular Life Sciences.2018; 75(22): 4151.     CrossRef
  • High-throughput Protein and mRNA Expression–based Classification of Gastric Cancers Can Identify Clinically Distinct Subtypes, Concordant With Recent Molecular Classifications
    Sangjeong Ahn, So-Jeong Lee, Yonugkeum Kim, Ahrong Kim, Nari Shin, Kyung Un Choi, Chang-Hun Lee, Gi Yeong Huh, Kyong-Mee Kim, Namrata Setia, Gregory Y. Lauwers, Do Youn Park
    American Journal of Surgical Pathology.2017; 41(1): 106.     CrossRef
  • Molecular Testing for Gastrointestinal Cancer
    Hye Seung Lee, Woo Ho Kim, Yoonjin Kwak, Jiwon Koh, Jeong Mo Bae, Kyoung-Mee Kim, Mee Soo Chang, Hye Seung Han, Joon Mee Kim, Hwal Woong Kim, Hee Kyung Chang, Young Hee Choi, Ji Y. Park, Mi Jin Gu, Min Jin Lhee, Jung Yeon Kim, Hee Sung Kim, Mee-Yon Cho
    Journal of Pathology and Translational Medicine.2017; 51(2): 103.     CrossRef
  • Molecular testing of gastrointestinal tumours
    Matthew Evans, Matthew Smith, Brendan O'Sullivan, Philippe Taniere
    Diagnostic Histopathology.2017; 23(10): 442.     CrossRef
  • Gastric Carcinomas With Lymphoid Stroma
    Raul S Gonzalez, Justin M M Cates, Frank Revetta, Loralee A McMahon, Kay Washington
    American Journal of Clinical Pathology.2017; 148(6): 477.     CrossRef
  • Meta-Analysis of Prognostic Role of Ki-67 Labeling Index in Gastric Carcinoma
    Jung-Soo Pyo, Nae Yu Kim
    The International Journal of Biological Markers.2017; 32(4): 447.     CrossRef
  • Tissue-Agnostic Drug Development
    Keith T. Flaherty, Dung T. Le, Steven Lemery
    American Society of Clinical Oncology Educational Book.2017; (37): 222.     CrossRef
  • Programmed death ligand-1 and MET co-expression is a poor prognostic factor in gastric cancers after resection
    Mi Jung Kwon, Kab-Choong Kim, Eun Sook Nam, Seong Jin Cho, Hye-Rim Park, Soo Kee Min, Jinwon Seo, Ji-Young Choe, Hye Kyung Lee, Ho Suk Kang, Kyueng-Whan Min
    Oncotarget.2017; 8(47): 82399.     CrossRef
  • Hypermutation and microsatellite instability in gastrointestinal cancers
    Kizuki Yuza, Masayuki Nagahashi, Satoshi Watanabe, Kazuaki Takabe, Toshifumi Wakai
    Oncotarget.2017; 8(67): 112103.     CrossRef
  • The emerging role of immunotherapy in gastric and esophageal adenocarcinoma
    Bruno Bockorny, Eirini Pectasides
    Future Oncology.2016; 12(15): 1833.     CrossRef
  • Expression of Mismatch Repair Proteins in Early and Advanced Gastric Cancer in Poland
    Katarzyna Karpińska-Kaczmarczyk, Magdalena Lewandowska, Małgorzata Ławniczak, Andrzej Białek, Elżbieta Urasińska
    Medical Science Monitor.2016; 22: 2886.     CrossRef
  • Immunotherapy for Gastroesophageal Cancer
    Emily Goode, Elizabeth Smyth
    Journal of Clinical Medicine.2016; 5(10): 84.     CrossRef
  • Lauren classification and individualized chemotherapy in gastric cancer
    JUNLI MA, HONG SHEN, LINDA KAPESA, SHAN ZENG
    Oncology Letters.2016; 11(5): 2959.     CrossRef
  • High-risk and low-risk gastric cancer areas in Italy and its association with microsatellite instability
    Karol Polom, Daniele Marrelli, Valeria Pascale, Giandomenico Roviello, Costantino Voglino, Henry Rho, Carla Vindigni, Mario Marini, Raffaele Macchiarelli, Franco Roviello
    Journal of Cancer Research and Clinical Oncology.2016; 142(8): 1817.     CrossRef
  • MUC2 Expression Is Correlated with Tumor Differentiation and Inhibits Tumor Invasion in Gastric Carcinomas: A Systematic Review and Meta-analysis
    Jung-Soo Pyo, Jin Hee Sohn, Guhyun Kang, Dong-Hoon Kim, Kyungeun Kim, In-Gu Do, Dong Hyun Kim
    Journal of Pathology and Translational Medicine.2015; 49(3): 249.     CrossRef
  • Correlation between microsatellite instability-high phenotype and occult lymph node metastasis in gastric carcinoma
    Jiwoon Choi, Soo Kyung Nam, Do Joong Park, Hwal Woong Kim, Hyung-Ho Kim, Woo Ho Kim, Hye Seung Lee
    APMIS.2015; 123(3): 215.     CrossRef
  • Clinicopathologic and molecular features associated with patient age in gastric cancer
    Ji Yeon Seo, Eun Hyo Jin, Hyun Jin Jo, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Nayoung Kim, Hyun Chae Jung, Dong Ho Lee
    World Journal of Gastroenterology.2015; 21(22): 6905.     CrossRef
  • Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy
    Ismael Riquelme, Kathleen Saavedra, Jaime A. Espinoza, Helga Weber, Patricia García, Bruno Nervi, Marcelo Garrido, Alejandro H. Corvalán, Juan Carlos Roa, Carolina Bizama
    Oncotarget.2015; 6(28): 24750.     CrossRef
  • A phylogenetic model for understanding the effect of gene duplication on cancer progression
    Qin Ma, Jaxk H. Reeves, David A. Liberles, Lili Yu, Zheng Chang, Jing Zhao, Juan Cui, Ying Xu, Liang Liu
    Nucleic Acids Research.2014; 42(5): 2870.     CrossRef
  • The analysis of microsatellite instability in extracolonic gastrointestinal malignancy
    Andrew S. Williams, Weei-Yuarn Huang
    Pathology.2013; 45(6): 540.     CrossRef
Non-small Cell Lung Cancer with Concomitant EGFR, KRAS, and ALK Mutation: Clinicopathologic Features of 12 Cases
Taebum Lee, Boram Lee, Yoon-La Choi, Joungho Han, Myung-Ju Ahn, Sang-Won Um
J Pathol Transl Med. 2016;50(3):197-203.   Published online April 18, 2016
DOI: https://doi.org/10.4132/jptm.2016.03.09
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AbstractAbstract PDF
Background
Although epidermal growth factor receptor (EGFR), v-Ki-ras2 Kirsten rat sarcoma viral oncogene (KRAS), and anaplastic lymphoma kinase (ALK) mutations in non-small cell lung cancer (NSCLC) were thought to be mutually exclusive, some tumors harbor concomitant mutations. Discovering a driver mutation on the basis of morphologic features and therapeutic responses with mutation analysis can be used to understand pathogenesis and predict resistance in targeted therapy.
Methods
In 6,637 patients with NSCLC, 12 patients who had concomitant mutations were selected and clinicopathologic features were reviewed. Clinical characteristics included sex, age, smoking history, previous treatment, and targeted therapy with response and disease-free survival. Histologic features included dominant patterns, nuclear and cytoplasmic features.
Results
All patients were diagnosed with adenocarcinoma and had an EGFR mutation. Six patients had concomitant KRAS mutations and the other six had ALK mutations. Five of six EGFR-KRAS mutation patients showed papillary and acinar histologic patterns with hobnail cells. Three of six received EGFR tyrosine kinase inhibitor (TKI) and showed partial response for 7–29 months. All six EGFR-ALK mutation patients showed solid or cribriform patterns and three had signet ring cells. Five of six EGFR-ALK mutation patients received EGFR TKI and/or ALK inhibitor and four showed partial response or stable disease, except for one patient who had acquired an EGFR mutation.
Conclusions
EGFR and ALK mutations play an important role as driver mutations in double mutated NSCLC, and morphologic analysis can be used to predict treatment response.

Citations

Citations to this article as recorded by  
  • Artificial Intelligence in Lung Cancer Imaging: From Data to Therapy
    Michaela Cellina, Giuseppe De Padova, Nazarena Caldarelli, Dario Libri, Maurizio Cè, Carlo Martinenghi, Marco Alì, Sergio Papa, Gianpaolo Carrafiello
    Critical Reviews™ in Oncogenesis.2024; 29(2): 1.     CrossRef
  • Artificial Intelligence for Cardiothoracic Imaging: Overview of Current and Emerging Applications
    Bruno Hochhegger, Romulo Pasini, Alysson Roncally Carvalho, Rosana Rodrigues, Stephan Altmayer, Leonardo Kayat Bittencourt, Edson Marchiori, Reza Forghani
    Seminars in Roentgenology.2023; 58(2): 184.     CrossRef
  • Genomic Landscape of Primary Resistance to Osimertinib Among Hispanic Patients with EGFR-Mutant Non-Small Cell Lung Cancer (NSCLC): Results of an Observational Longitudinal Cohort Study
    Diego F. Chamorro, Andrés F. Cardona, July Rodríguez, Alejandro Ruiz-Patiño, Oscar Arrieta, Darwin A. Moreno-Pérez, Leonardo Rojas, Zyanya Lucia Zatarain-Barrón, Dora V. Ardila, Lucia Viola, Gonzalo Recondo, Juan B. Blaquier, Claudio Martín, Luis Raez, Su
    Targeted Oncology.2023; 18(3): 425.     CrossRef
  • Histone deacetylase inhibitor belinostat regulates metabolic reprogramming in killing KRAS‐mutant human lung cancer cells
    Rebecca M. Peter, Md. Shahid Sarwar, Sarah Z. Mostafa, Yujue Wang, Xiaoyang Su, Ah‐Ng Kong
    Molecular Carcinogenesis.2023; 62(8): 1136.     CrossRef
  • Differential Distribution of Brain Metastases from Non-Small Cell Lung Cancer Based on Mutation Status
    Bihong T. Chen, Taihao Jin, Ningrong Ye, Sean W. Chen, Russell C. Rockne, Stephanie Yoon, Isa Mambetsariev, Ebenezer Daniel, Ravi Salgia
    Brain Sciences.2023; 13(7): 1057.     CrossRef
  • Clinicopathological features and prognostic significance of pulmonary adenocarcinoma with signet ring cell components: meta-analysis and SEER analysis
    Yang Tan, Ying-he Huang, Jia-wen Xue, Rui Zhang, Run Liu, Yan Wang, Zhen-Bo Feng
    Clinical and Experimental Medicine.2023; 23(8): 4341.     CrossRef
  • Ganoderma microsporum immunomodulatory protein as an extracellular epidermal growth factor receptor (EGFR) degrader for suppressing EGFR-positive lung cancer cells
    Wei-Jyun Hua, Hsin Yeh, Zhi-Hu Lin, Ai-Jung Tseng, Li-Chen Huang, Wei-Lun Qiu, Tsung-Hsi Tu, Ding-Han Wang, Wei-Hung Hsu, Wei-Lun Hwang, Tung-Yi Lin
    Cancer Letters.2023; 578: 216458.     CrossRef
  • Next generation sequencing for detection of EGFR alterations in NSCLC: is more better?
    Ullas Batra, Shrinidhi Nathany, Mansi Sharma, Parveen Jain, Anurag Mehta
    Journal of Clinical Pathology.2022; 75(3): 164.     CrossRef
  • Enkurin domain containing 1 (ENKD1) regulates the proliferation, migration and invasion of non‐small cell lung cancer cells
    Ting Song, Peng Zhou, Chunjiao Sun, Na He, Haixia Li, Jie Ran, Jun Zhou, Yue Wu, Min Liu
    Asia-Pacific Journal of Clinical Oncology.2022;[Epub]     CrossRef
  • Targeting Mutant Kirsten Rat Sarcoma Viral Oncogene Homolog in Non-Small Cell Lung Cancer: Current Difficulties, Integrative Treatments and Future Perspectives
    Jia-Xin Li, Run-Ze Li, Lin-Rui Ma, Peng Wang, Dong-Han Xu, Jie Huang, Li-Qi Li, Ling Tang, Ying Xie, Elaine Lai-Han Leung, Pei-Yu Yan
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Histone H3K9 methyltransferase SETDB1 augments invadopodia formation to promote tumor metastasis
    Shuhei Ueshima, Jia Fang
    Oncogene.2022; 41(24): 3370.     CrossRef
  • ESMO expert consensus statements on the management of EGFR mutant non-small-cell lung cancer
    A. Passaro, N. Leighl, F. Blackhall, S. Popat, K. Kerr, M.J. Ahn, M.E. Arcila, O. Arrieta, D. Planchard, F. de Marinis, A.M. Dingemans, R. Dziadziuszko, C. Faivre-Finn, J. Feldman, E. Felip, G. Curigliano, R. Herbst, P.A. Jänne, T. John, T. Mitsudomi, T.
    Annals of Oncology.2022; 33(5): 466.     CrossRef
  • Molecular Targets in Lung Cancer: Study of the Evolution of Biomarkers Associated with Treatment with Tyrosine Kinase Inhibitors—Has NF1 Tumor Suppressor a Key Role in Acquired Resistance?
    Begoña O. Alen, Lara S. Estévez-Pérez, María Teresa Hermida-Romero, Ana Reguera-Arias, Rosario García-Campelo, Mercedes de la Torre-Bravos, Ángel Concha
    Cancers.2022; 14(14): 3323.     CrossRef
  • Analytical and clinical validation of a custom 15-gene next-generation sequencing panel for the evaluation of circulating tumor DNA mutations in patients with advanced non-small-cell lung cancer
    Yock Ping Chow, Norziha Zainul Abidin, Ken Siong Kow, Lye Mun Tho, Chieh Lee Wong, Rama Krishna Kancha
    PLOS ONE.2022; 17(10): e0276161.     CrossRef
  • Potential Therapeutic Strategy for EGFR-Mutant Lung Cancer With Concomitant EML4-ALK Rearrangement—Combination of EGFR Tyrosine Kinase Inhibitors and ALK Inhibitors
    Ming-Hung Huang, Jih-Hsiang Lee, Pei-Shan Hung, James Chih-Hsin Yang
    JTO Clinical and Research Reports.2022; 3(11): 100405.     CrossRef
  • Artificial Intelligence in Lung Cancer Imaging: Unfolding the Future
    Michaela Cellina, Maurizio Cè, Giovanni Irmici, Velio Ascenti, Natallia Khenkina, Marco Toto-Brocchi, Carlo Martinenghi, Sergio Papa, Gianpaolo Carrafiello
    Diagnostics.2022; 12(11): 2644.     CrossRef
  • A single center analysis of first-line treatment in advanced KRAS mutant non-small cell lung cancer: real-world practice
    Yanxia Liu, Yuan Gao, Ying Wang, Cong Zhao, Zhiyun Zhang, Baolan Li, Tongmei Zhang
    BMC Cancer.2022;[Epub]     CrossRef
  • High frequency of KRAS and EGFR mutation profiles in BRAF-negative thyroid carcinomas in Indonesia
    Didik Setyo Heriyanto, Vincent Laiman, Nikko Vanda Limantara, Widyan Putra Anantawikrama, Fara Silvia Yuliani, Rita Cempaka, Sumadi Lukman Anwar
    BMC Research Notes.2022;[Epub]     CrossRef
  • Targeted next-generation sequencing for cancer-associated gene mutation and copy number detection in 206 patients with non–small-cell lung cancer
    Songbai Zheng, Xiaodan Wang, Ying Fu, Beibei Li, Jianhua Xu, Haifang Wang, Zhen Huang, Hui Xu, Yurong Qiu, Yaozhou Shi, Kui Li
    Bioengineered.2021; 12(1): 791.     CrossRef
  • How mathematical modeling could contribute to the quantification of metastatic tumor burden under therapy: insights in immunotherapeutic treatment of non-small cell lung cancer
    Pirmin Schlicke, Christina Kuttler, Christian Schumann
    Theoretical Biology and Medical Modelling.2021;[Epub]     CrossRef
  • A case of concomitant EGFR/ALK alteration against a mutated EGFR background in early-stage lung adenocarcinoma
    Ki-Chang Lee, Jiwon Koh, Doo Hyun Chung, Yoon Kyung Jeon
    Journal of Pathology and Translational Medicine.2021; 55(2): 139.     CrossRef
  • Malfeasance of KRAS mutations in carcinogenesis
    Rupal Tripathi, Shrinidhi Nathany, Anurag Mehta, Ullas Batra, Sakshi Mattoo, Mansi Sharma
    Clinical and Experimental Medicine.2021; 21(3): 439.     CrossRef
  • Detection of Low-Frequency KRAS Mutations in cfDNA From EGFR-Mutated NSCLC Patients After First-Line EGFR Tyrosine Kinase Inhibitors
    Giorgia Nardo, Jessica Carlet, Ludovica Marra, Laura Bonanno, Alice Boscolo, Alessandro Dal Maso, Andrea Boscolo Bragadin, Stefano Indraccolo, Elisabetta Zulato
    Frontiers in Oncology.2021;[Epub]     CrossRef
  • Non-Small Cell Lung Cancer Harboring Concurrent EGFR Genomic Alterations: A Systematic Review and Critical Appraisal of the Double Dilemma
    Valerio Gristina, Maria La Mantia, Antonio Galvano, Sofia Cutaia, Nadia Barraco, Marta Castiglia, Alessandro Perez, Marco Bono, Federica Iacono, Martina Greco, Katia Calcara, Valentina Calò, Sergio Rizzo, Lorena Incorvaia, Maria Chiara Lisanti, Giulia San
    Journal of Molecular Pathology.2021; 2(2): 173.     CrossRef
  • Testing for EGFR Mutations and ALK Rearrangements in Advanced Non-Small-Cell Lung Cancer: Considerations for Countries in Emerging Markets
    Mercedes L Dalurzo, Alejandro Avilés-Salas, Fernando Augusto Soares, Yingyong Hou, Yuan Li, Anna Stroganova, Büge Öz, Arif Abdillah, Hui Wan, Yoon-La Choi
    OncoTargets and Therapy.2021; Volume 14: 4671.     CrossRef
  • Untangling the KRAS mutated lung cancer subsets and its therapeutic implications
    Kulshrestha Ritu, Pawan Kumar, Amit Singh, K. Nupur, Sonam Spalgias, Parul Mrigpuri, Rajkumar
    Molecular Biomedicine.2021;[Epub]     CrossRef
  • Lorlatinib Induces Durable Disease Stabilization in a Pancreatic Cancer Patient with a ROS1 p.L1950F Mutation: Case Report
    Janna-Lisa Velthaus, Peter Iglauer, Ronald Simon, Carsten Bokemeyer, Peter Bannas, Niklas Beumer, Charles D. Imbusch, Eray Goekkurt, Sonja Loges
    Oncology Research and Treatment.2021; 44(9): 495.     CrossRef
  • Proteasome-dependent degradation of Smad7 is critical for lung cancer metastasis
    Lu Tong, Shihui Shen, Quan Huang, Junjiang Fu, Tianzhen Wang, Linian Pan, Pei Zhang, Geng Chen, Tingmei Huang, Ke Li, Qingwu Liu, Shaofang Xie, Xiao Yang, Robb E. Moses, Xiaotao Li, Lei Li
    Cell Death & Differentiation.2020; 27(6): 1795.     CrossRef
  • Circulating cell-free DNA as a diagnostic and prognostic biomarker for non-small-cell lung cancer: a systematic review and meta-analysis
    Zhoumiao Chen, Huiwen Miao, Qingxin Zeng, Shaohua Xu, Zhao Chen, Kai Liu
    Biomarkers in Medicine.2020; 14(7): 587.     CrossRef
  • Influence of EGFR-activating mutations on sensitivity to tyrosine kinase inhibitors in a KRAS mutant non-small cell lung cancer cell line
    Yoshinori Tsukumo, Mikihiko Naito, Takayoshi Suzuki, Srikumar Chellappan
    PLOS ONE.2020; 15(3): e0229712.     CrossRef
  • KRAS oncogene may be another target conquered in non‐small cell lung cancer (NSCLC)
    Hanxiao Chen, Jun Zhao
    Thoracic Cancer.2020; 11(12): 3425.     CrossRef
  • Epidemiologic Features of NSCLC Gene Alterations in Hispanic Patients from Puerto Rico
    Ruifang Zheng, Zhiwei Yin, Albert Alhatem, Derek Lyle, Bei You, Andrew S. Jiang, Dongfang Liu, Zsolt Jobbagy, Qing Wang, Seena Aisner, Jie-Gen Jiang
    Cancers.2020; 12(12): 3492.     CrossRef
  • Comprehensive pancancer genomic analysis reveals (RTK)-RAS-RAF-MEK as a key dysregulated pathway in cancer: Its clinical implications
    Robin Imperial, Omer M Toor, Arif Hussain, Janakiraman Subramanian, Ashiq Masood
    Seminars in Cancer Biology.2019; 54: 14.     CrossRef
  • Epidermal growth factor receptor (EGFR), KRAS, and BRAF mutations in lung adenocarcinomas: A study from India
    Varsha Singh, Prerna Guleria, Prabhat Singh Malik, Anant Mohan, Sanjay Thulkar, R M Pandey, Kalpana Luthra, Sudheer Arava, Ruma Ray, Deepali Jain
    Current Problems in Cancer.2019; 43(5): 391.     CrossRef
  • Clinical Validation of Coexisting Activating Mutations Within EGFR, Mitogen-Activated Protein Kinase, and Phosphatidylinositol 3-Kinase Pathways in Lung Cancers
    Federico De Marchi, Lisa Haley, Henderson Fryer, Junaid Ibrahim, Katie Beierl, Gang Zheng, Christopher D. Gocke, James R. Eshleman, Deborah Belchis, Peter Illei, Ming-Tseh Lin
    Archives of Pathology & Laboratory Medicine.2019; 143(2): 174.     CrossRef
  • A sequential Monte Carlo algorithm for inference of subclonal structure in cancer
    Oyetunji E. Ogundijo, Kaiyi Zhu, Xiaodong Wang, Dimitris Anastassiou, Xiang Li
    PLOS ONE.2019; 14(1): e0211213.     CrossRef
  • The Presence of Concomitant Mutations Affects the Activity of EGFR Tyrosine Kinase Inhibitors in EGFR-Mutant Non-Small Cell Lung Cancer (NSCLC) Patients
    Anna Rachiglio, Francesca Fenizia, Maria Piccirillo, Domenico Galetta, Lucio Crinò, Bruno Vincenzi, Emiddio Barletta, Carmine Pinto, Francesco Ferraù, Matilde Lambiase, Agnese Montanino, Cristin Roma, Vienna Ludovini, Elisabetta Montagna, Antonella De Luc
    Cancers.2019; 11(3): 341.     CrossRef
  • Concurrent Driver Gene Mutations as Negative Predictive Factors in Epidermal Growth Factor Receptor-Positive Non-Small Cell Lung Cancer
    Minjiang Chen, Yan Xu, Jing Zhao, Wei Zhong, Li Zhang, Yalan Bi, Mengzhao Wang
    EBioMedicine.2019; 42: 304.     CrossRef
  • Anaplastic Lymphoma Kinase (ALK)-positive Tumors
    Rohan Gupta, Idoroenyi Amanam, Syed Rahmanuddin, Isa Mambetsariev, Yingyu Wang, Charity Huang, Karen Reckamp, Lalit Vora, Ravi Salgia
    American Journal of Clinical Oncology.2019; 42(4): 337.     CrossRef
  • Clinical features and therapeutic options in non‐small cell lung cancer patients with concomitant mutations of EGFR, ALK, ROS1, KRAS or BRAF
    Xibin Zhuang, Chao Zhao, Jiayu Li, Chunxia Su, Xiaoxia Chen, Shengxiang Ren, Xuefei Li, Caicun Zhou
    Cancer Medicine.2019; 8(6): 2858.     CrossRef
  • Intrinsic resistance to EGFR-Tyrosine Kinase Inhibitors in EGFR-Mutant Non-Small Cell Lung Cancer: Differences and Similarities with Acquired Resistance
    Santoni-Rugiu, Melchior, Urbanska, Jakobsen, Stricker, Grauslund, Sørensen
    Cancers.2019; 11(7): 923.     CrossRef
  • Clinical outcome of treatment of metastatic non-small cell lung cancer in patients harboring uncommon EGFR mutation
    J. Chantharasamee, N. Poungvarin, P. Danchaivijitr, S. Techawatanawanna
    BMC Cancer.2019;[Epub]     CrossRef
  • Deregulated lncRNA expression profile in the mouse lung adenocarcinomas with KRAS‐G12D mutation and P53 knockout
    Meiqin Zhang, Nan Jiang, Renjie Cui, Sichen Du, Huayuan Ou, Tinglan Chen, Runsheng Ge, Duan Ma, Jin Zhang
    Journal of Cellular and Molecular Medicine.2019; 23(10): 6978.     CrossRef
  • Open-Sourced CIViC Annotation Pipeline to Identify and Annotate Clinically Relevant Variants Using Single-Molecule Molecular Inversion Probes
    Erica K. Barnell, Adam Waalkes, Matt C. Mosior, Kelsi Penewit, Kelsy C. Cotto, Arpad M. Danos, Lana M. Sheta, Katie M. Campbell, Kilannin Krysiak, Damian Rieke, Nicholas C. Spies, Zachary L. Skidmore, Colin C. Pritchard, Todd A. Fehniger, Ravindra Uppalur
    JCO Clinical Cancer Informatics.2019; (3): 1.     CrossRef
  • EGFR, KRAS, BRAF, ALK, and cMET genetic alterations in 1440 Sardinian patients with lung adenocarcinoma
    Maria Colombino, Panagiotis Paliogiannis, Antonio Cossu, Davide Adriano Santeufemia, Maria Cristina Sini, Milena Casula, Grazia Palomba, Antonella Manca, Marina Pisano, Valentina Doneddu, Giuseppe Palmieri
    BMC Pulmonary Medicine.2019;[Epub]     CrossRef
  • Concomitant Presence of EGFR and ALK Fusion Gene Mutation in Adenocarcinoma of Lung: A Case Report and Review of the Literature
    Nishitha Thumallapally, Hana Yu, Mohammad Farhan, Uroosa Ibrahim, Maricel Odiami
    Journal of Pharmacy Practice.2018; 31(2): 244.     CrossRef
  • Double Trouble: A Case Series on Concomitant Genetic Aberrations in NSCLC
    Nele Van Der Steen, Yves Mentens, Marc Ramael, Leticia G. Leon, Paul Germonpré, Jose Ferri, David R. Gandara, Elisa Giovannetti, Godefridus J. Peters, Patrick Pauwels, Christian Rolfo
    Clinical Lung Cancer.2018; 19(1): 35.     CrossRef
  • KRAS oncogene in non-small cell lung cancer: clinical perspectives on the treatment of an old target
    Marta Román, Iosune Baraibar, Inés López, Ernest Nadal, Christian Rolfo, Silvestre Vicent, Ignacio Gil-Bazo
    Molecular Cancer.2018;[Epub]     CrossRef
  • Pulmonary Adenocarcinoma, Harboring Both an EGFR Mutation and ALK Rearrangement, Presenting a Stable Disease to Erlotinib and a Partial Response to Alectinib
    Akira Yokoyama, Atsuhisa Tamura, Kazuko Miyakawa, Kei Kusaka, Masahiro Shimada, Takashi Hirose, Hirotoshi Matsui, Masashi Kitani, Akira Hebisawa, Ken Ohta
    Internal Medicine.2018; 57(16): 2377.     CrossRef
  • Long-term survival with erlotinib in advanced lung adenocarcinoma harboring synchronous EGFR G719S and KRAS G12C mutations
    Biagio Ricciuti, Sara Baglivo, Vienna Ludovini, Angelo Sidoni, Giulio Metro, Marta Brambilla, Annamaria Siggillino, Maria Sole Reda, Alberto Rebonato, Daniele Maiettini, Rita Chiari
    Lung Cancer.2018; 120: 70.     CrossRef
  • Concomitant driver mutations in advanced EGFR-mutated non-small-cell lung cancer and their impact on erlotinib treatment
    Jan Nyrop Jakobsen, Eric Santoni-Rugiu, Morten Grauslund, Linea Melchior, Jens Benn Sørensen
    Oncotarget.2018; 9(40): 26195.     CrossRef
  • Implications of KRAS mutations in acquired resistance to treatment in NSCLC
    Marzia Del Re, Eleonora Rofi, Giuliana Restante, Stefania Crucitta, Elena Arrigoni, Stefano Fogli, Massimo Di Maio, Iacopo Petrini, Romano Danesi
    Oncotarget.2018; 9(5): 6630.     CrossRef
  • Alk Immunohistochemistry is Highly Sensitive and Specific for the Detection of Alk Translocated Lung Adenocarcinomas: Lessons from An Audit of Lung Cancer Molecular Testing
    YC Kheng, K Walsh, L Williams, WA Wallace, DJ Harrison, A Oniscu
    Journal of the Royal College of Physicians of Edinburgh.2018; 48(1): 20.     CrossRef
  • Targeting KRAS mutated non-small cell lung cancer: A history of failures and a future of hope for a diverse entity
    Alexios Matikas, Dimitrios Mistriotis, Vasilios Georgoulias, Athanasios Kotsakis
    Critical Reviews in Oncology/Hematology.2017; 110: 1.     CrossRef
  • Clinical Outcome of ALK -Positive Non–Small Cell Lung Cancer (NSCLC) Patients with De Novo EGFR or KRAS Co-Mutations Receiving Tyrosine Kinase Inhibitors (TKIs)
    Sabine Schmid, Oliver Gautschi, Sacha Rothschild, Michael Mark, Patrizia Froesch, Dirk Klingbiel, Hermann Reichegger, Wolfram Jochum, Joachim Diebold, Martin Früh
    Journal of Thoracic Oncology.2017; 12(4): 681.     CrossRef
  • EGFR and KRAS molecular genotyping for pulmonary carcinomas: Feasibility of a simple and rapid technique implementable in any department of pathology
    Vincent Thomas De Montpréville, Maria-Rosa Ghigna, Ludovic Lacroix, Antoinette Lemoine, Benjamin Besse, Olaf Mercier, Élie Fadel, Peter Dorfmuller, Thierry Le Chevalier
    Pathology - Research and Practice.2017; 213(7): 793.     CrossRef
  • MET Exon 14 Skipping Mutations in Lung Adenocarcinoma: Clinicopathologic Implications and Prognostic Values
    Geun Dong Lee, Seung Eun Lee, Doo-Yi Oh, Dan-bi Yu, Hae Min Jeong, Jooseok Kim, Sungyoul Hong, Hun Soon Jung, Ensel Oh, Ji-Young Song, Mi-Sook Lee, Mingi Kim, Kyungsoo Jung, Jhingook Kim, Young Kee Shin, Yoon-La Choi, Hyeong Ryul Kim
    Journal of Thoracic Oncology.2017; 12(8): 1233.     CrossRef
  • Non-Small-Cell Lung Cancer (NSCLC) Harboring ALK Translocations: Clinical Characteristics and Management in a Real-Life Setting: a French Retrospective Analysis (GFPC 02–14 Study)
    Jean-Bernard Auliac, Isabelle Monnet, Catherine Dubos-Arvis, Anne Marie Chiappa, Nathalie Baize, Suzana Bota, Alain Vergnenegre, Helene Doubre, Chrystele Locher, Acya Bizieux, Gilles Robinet, Christos Chouaid
    Targeted Oncology.2017; 12(6): 833.     CrossRef
  • Concomitant EML4-ALK rearrangement and EGFR mutation in non-small cell lung cancer patients: a literature review of 100 cases
    Giuseppe Lo Russo, Martina Imbimbo, Giulia Corrao, Claudia Proto, Diego Signorelli, Milena Vitali, Monica Ganzinelli, Laura Botta, Nicoletta Zilembo, Filippo de Braud, Marina Chiara Garassino
    Oncotarget.2017; 8(35): 59889.     CrossRef
  • Management of non-small cell lung cancer in the era of personalized medicine
    Gaetano Rocco, Alessandro Morabito, Alessandra Leone, Paolo Muto, Francesco Fiore, Alfredo Budillon
    The International Journal of Biochemistry & Cell Biology.2016; 78: 173.     CrossRef
  • A long-term survivor of non-small-cell lung cancer harboring concomitant EGFR mutation and ALK translocation
    Fumio Imamura, Takako Inoue, Madoka Kimura, Kazumi Nishino, Toru Kumagai
    Respiratory Medicine Case Reports.2016; 19: 137.     CrossRef
Review
Epstein-Barr Virus–Associated Lymphoproliferative Disorders: Review and Update on 2016 WHO Classification
Hyun-Jung Kim, Young Hyeh Ko, Ji Eun Kim, Seung-Sook Lee, Hyekyung Lee, Gyeongsin Park, Jin Ho Paik, Hee Jeong Cha, Yoo-Duk Choi, Jae Ho Han, Jooryung Huh
J Pathol Transl Med. 2017;51(4):352-358.   Published online June 5, 2017
DOI: https://doi.org/10.4132/jptm.2017.03.15
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AbstractAbstract PDF
Epstein-Barr virus (human herpesvirus-4) is very common virus that can be detected in more than 95% of the human population. Most people are asymptomatic and live their entire lives in a chronically infected state (IgG positive). However, in some populations, the Epstein-Barr virus (EBV) has been involved in the occurrence of a wide range of B-cell lymphoproliferative disorders (LPDs), including Burkitt lymphoma, classic Hodgkin’s lymphoma, and immune–deficiency associated LPDs (post-transplant and human immunodeficiency virus–associated LPDs). T-cell LPDs have been reported to be associated with EBV with a subset of peripheral T-cell lymphomas, angioimmunoblastic T-cell lymphomas, extranodal nasal natural killer/T-cell lymphomas, and other rare histotypes. This article reviews the current evidence covering EBV-associated LPDs based on the 2016 classification of the World Health Organization. These LPD entities often pose diagnostic challenges, both clinically and pathologically, so it is important to understand their unique pathophysiology for correct diagnoses and optimal management.

Citations

Citations to this article as recorded by  
  • Epstein–Barr virus‐positive monoclonal lymphoplasmacytic proliferation associated with neurosyphilis in an immunocompetent patient: A case report
    Takashi Hibiya, Kiyotaka Nagahama, Yoshie Matsumoto, Kuniaki Saito, Nobuyoshi Sasaki, Keiichi Kobayashi, Akiyasu Otsu, Teppei Shimasaki, Kengo Takeuchi, Yoshiaki Shiokawa, Motoo Nagane, Junji Shibahara
    Neuropathology.2024; 44(2): 104.     CrossRef
  • Epstein-Barr virus-positive iris diffuse large B-cell lymphoma detected by metagenomic next-generation sequencing
    Xiao-na Wang, Jing Hong, Yong-gen Xu, Pei Zhang, Ying-yu Li, Hong-liang Dou, Hai-ping Li
    BMC Ophthalmology.2024;[Epub]     CrossRef
  • Pharmacological Modulation of the Crosstalk between Aberrant Janus Kinase Signaling and Epigenetic Modifiers of the Histone Deacetylase Family to Treat Cancer
    Al-Hassan M. Mustafa, Oliver H. Krämer, Lynette Daws
    Pharmacological Reviews.2023; 75(1): 35.     CrossRef
  • Autophagy-associated immune dysregulation and hyperplasia in a patient with compound heterozygous mutations in ATG9A
    Guowu Hu, Pia J Hauk, Nannan Zhang, Waleed Elsegeiny, Carlos M. Guardia, Amy Kullas, Kevin Crosby, Robin R. Deterding, Michaela Schedel, Paul Reynolds, Jordan K Abbott, Vijaya Knight, Stefania Pittaluga, Mark Raffeld, Sergio D. Rosenzweig, Juan S. Bonifac
    Autophagy.2023; 19(2): 678.     CrossRef
  • When to suspect inborn errors of immunity in Epstein–Barr virus–related lymphoproliferative disorders
    Keith A. Sacco, Luigi D. Notarangelo, Ottavia M. Delmonte
    Clinical Microbiology and Infection.2023; 29(4): 457.     CrossRef
  • Primary head and neck cancer cell cultures are susceptible to proliferation of Epstein-Barr virus infected lymphocytes
    Senyao Shao, Lars Uwe Scholtz, Sarah Gendreizig, Laura Martínez-Ruiz, Javier Florido, Germaine Escames, Matthias Schürmann, Carsten Hain, Leonie Hose, Almut Mentz, Pascal Schmidt, Menghang Wang, Peter Goon, Michael Wehmeier, Frank Brasch, Jörn Kalinowski,
    BMC Cancer.2023;[Epub]     CrossRef
  • Clinical and genetic characterization of Epstein-Barr virus–associated T/NK-cell lymphoproliferative diseases
    Hui Luo, Dan Liu, Wenbing Liu, Jin Jin, Xiaoman Bi, Peiling Zhang, Jia Gu, Miao Zheng, Min Xiao, Xin Liu, Jianfeng Zhou, Qian-Fei Wang
    Journal of Allergy and Clinical Immunology.2023; 151(4): 1096.     CrossRef
  • Outcomes of programmed death protein-1 inhibitors treatment of chronic active Epstein Barr virus infection: A single center retrospective analysis
    Yaxian Ma, Peiling Zhang, Yuhan Bao, Hui Luo, Jiachen Wang, Liang Huang, Miao Zheng
    Frontiers in Immunology.2023;[Epub]     CrossRef
  • Pathogenesis, treatment and prevention of diseases caused by Epstein–Barr virus
    A. G. Rumyantsev
    Pediatric Hematology/Oncology and Immunopathology.2023; 22(2): 166.     CrossRef
  • Epstein–Barr virus-associated B-cell lymphoproliferative disorder meeting the definition of CAEBV B cell disease: a case report
    Yaxian Ma, Yuhan Bao, Miao Zheng
    BMC Infectious Diseases.2023;[Epub]     CrossRef
  • Unpacking the CNS Manifestations of Epstein-Barr Virus: An Imaging Perspective
    N. Soni, M. Ora, R. Singh, P. Mehta, A. Agarwal, G. Bathla
    American Journal of Neuroradiology.2023; 44(9): 1002.     CrossRef
  • Oncoviruses: Induction of cancer development and metastasis by increasing anoikis resistance
    Zahra Sobhi Amjad, Ali Shojaeian, Javid Sadri Nahand, Mobina Bayat, Mohammad Taghizadieh, Mosayeb Rostamian, Farhad Babaei, Mohsen Moghoofei
    Heliyon.2023; 9(12): e22598.     CrossRef
  • Frequency and association of Epstein-Barr Virus genotype in rheumatoid arthritis patients of Khyber Pakhtunkhwa, Pakistan
    Ayesha Munir, Suleman Khan, Sanaullah Khan, Sobia Attaullah, Mehwish Munir, Aisha Saleem, Ijaz Ali, Hideo Kato
    PLOS ONE.2023; 18(12): e0295124.     CrossRef
  • Successful treatment by using a modified SMILE regimen and autologous hematopoietic stem cell transplantation in a pediatric primary EBV-positive nodular NK/T cell lymphoma patient
    Jian Li, Juxin Ye, Yongren Wang, Jun Wang, Yongjun Fang
    Annals of Hematology.2022; 101(2): 433.     CrossRef
  • Genetic errors of immunity distinguish pediatric nonmalignant lymphoproliferative disorders
    Lisa R. Forbes, Olive S. Eckstein, Nitya Gulati, Erin C. Peckham-Gregory, Nmazuo W. Ozuah, Joseph Lubega, Nader K. El-Mallawany, Jennifer E. Agrusa, M. Cecilia Poli, Tiphanie P. Vogel, Natalia S. Chaimowitz, Nicholas L. Rider, Emily M. Mace, Jordan S. Ora
    Journal of Allergy and Clinical Immunology.2022; 149(2): 758.     CrossRef
  • EBV-positive B-cell ulcerative proliferation in the oral cavity associated with EBV-negative follicular lymphoma in a patient with common variable immunodeficiency: A case report and review of the literature
    Waleed A. Alamoudi, Antoine Azar, Stefan K. Barta, Faizan Alawi, Takako I. Tanaka, Eric T. Stoopler, Thomas P. Sollecito
    Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.2022; 133(1): e10.     CrossRef
  • Necrotizing Follicular Lymphoma of the Inguinal Region with Sternbergoid Cells: Clinical–Pathological Features of a Challenging Entity
    Federico Scarmozzino, Marco Pizzi, Marta Sbaraglia, Luisa Santoro, Luca Frison, Silvia Nalio, Laura Bonaldi, Livio Trentin, Angelo Paolo Dei Tos
    Applied Sciences.2022; 12(3): 1290.     CrossRef
  • High percentages of peripheral blood T-cell activation in childhood Hodgkin's lymphoma are associated with inferior outcome
    Fengqing Cai, Hui Gao, Zhongsheng Yu, Kun Zhu, Weizhong Gu, Xiaoping Guo, Xiaojun Xu, Hongqiang Shen, Qiang Shu
    Frontiers in Medicine.2022;[Epub]     CrossRef
  • Case Report of a Novel NFkB Mutation in a Lymphoproliferative Disorder Patient
    Khashayar Danandeh, Parnian Jabbari, Elham Rayzan, Samaneh Zoghi, Sepideh Shahkarami, Raul Jimenez Heredia, Ana Krolo, Bibi Shahin Shamsian, Kaan Boztug, Nima Rezaei
    Endocrine, Metabolic & Immune Disorders - Drug Targets.2022; 22(10): 1040.     CrossRef
  • EBV-associated diseases: Current therapeutics and emerging technologies
    Srishti Chakravorty, Behdad Afzali, Majid Kazemian
    Frontiers in Immunology.2022;[Epub]     CrossRef
  • Clinical features and treatment strategies for post-transplant and iatrogenic immunodeficiency-associated lymphoproliferative disorders
    Akihiro Ohmoto, Shigeo Fuji
    Blood Reviews.2021; 49: 100807.     CrossRef
  • Comparative Study on Epstein-Barr Virus-Positive Mucocutaneous Ulcer and Methotrexate-Associated Lymphoproliferative Disorders Developed in the Oral Mucosa: A Case Series of 10 Patients and Literature Review
    Kyoichi Obata, Tatsuo Okui, Sawako Ono, Koki Umemori, Shoji Ryumon, Kisho Ono, Mayumi Yao, Norie Yoshioka, Soichiro Ibaragi, Akira Sasaki
    Diagnostics.2021; 11(8): 1375.     CrossRef
  • Primary age‐related EBV‐associated effusion‐based lymphoma successfully treated with rituximab and thoracentesis
    Justin J. Kuhlman, Muhamad Alhaj Moustafa, Alexander J. Tun, David M. Menke, Han W. Tun, Liuyan Jiang
    Clinical Case Reports.2021;[Epub]     CrossRef
  • Viral Manipulation of the Host Epigenome as a Driver of Virus-Induced Oncogenesis
    Shimaa Hassan AbdelAziz Soliman, Arturo Orlacchio, Fabio Verginelli
    Microorganisms.2021; 9(6): 1179.     CrossRef
  • Spontaneous regression of chronic epstein –Barr virus infection-related lymphoproliferative disease
    Bharti Kumari, Akshata Rao, ManickaSaravanan Subramanian, AparajitBallav Dey
    Journal of the Indian Academy of Geriatrics.2021; 17(1): 40.     CrossRef
  • The Pivotal Role of Viruses in the Pathogeny of Chronic Lymphocytic Leukemia: Monoclonal (Type 1) IgG K Cryoglobulinemia and Chronic Lymphocytic Leukemia Diagnosis in the Course of a Human Metapneumovirus Infection
    Jérémy Barben, Alain Putot, Anca-Maria Mihai, Jérémie Vovelle, Patrick Manckoundia
    Viruses.2021; 13(1): 115.     CrossRef
  • B cells in multiple sclerosis — from targeted depletion to immune reconstitution therapies
    Maria T. Cencioni, Miriam Mattoscio, Roberta Magliozzi, Amit Bar-Or, Paolo A. Muraro
    Nature Reviews Neurology.2021; 17(7): 399.     CrossRef
  • Development of Mast Cell and Eosinophil Hyperplasia and HLH/MAS-Like Disease in NSG-SGM3 Mice Receiving Human CD34+ Hematopoietic Stem Cells or Patient-Derived Leukemia Xenografts
    Laura J. Janke, Denise M. Imai, Heather Tillman, Rosalinda Doty, Mark J. Hoenerhoff, Jiajie J. Xu, Zachary T. Freeman, Portia Allen, Natalie Wall Fowlkes, Ilaria Iacobucci, Kirsten Dickerson, Charles G. Mullighan, Peter Vogel, Jerold E. Rehg
    Veterinary Pathology.2021; 58(1): 181.     CrossRef
  • Viral coinfections in COVID‐19
    Parisa S. Aghbash, Narges Eslami, Milad Shirvaliloo, Hossein B. Baghi
    Journal of Medical Virology.2021; 93(9): 5310.     CrossRef
  • Genetic predisposition to lymphomas: Overview of rare syndromes and inherited familial variants
    Bartosz Szmyd, Wojciech Mlynarski, Agata Pastorczak
    Mutation Research/Reviews in Mutation Research.2021; 788: 108386.     CrossRef
  • Acute Epstein‐Barr virus associated haemophagocytosis in an Asian female: What is the diagnosis?
    Soumya Ojha, Guiyi Ho, Cheryl X. Q. Lim, Siok B. Ng, Sanjay de Mel
    American Journal of Hematology.2021; 96(11): 1541.     CrossRef
  • Epstein Barr Virus: Development of Vaccines and Immune Cell Therapy for EBV-Associated Diseases
    Xinle Cui, Clifford M. Snapper
    Frontiers in Immunology.2021;[Epub]     CrossRef
  • Recent Advances in Diagnosis and Therapy of Angioimmunoblastic T Cell Lymphoma
    Mostafa F. Mohammed Saleh, Ahmed Kotb, Ghada E. M. Abdallah, Ibrahim N. Muhsen, Riad El Fakih, Mahmoud Aljurf
    Current Oncology.2021; 28(6): 5480.     CrossRef
  • Intestinal ulcers as an initial finding in EBV-associated lymphoproliferative disorder
    Sizhu Wang, Yinghuan Dai, Jie Zhang, Dalian Ou, Chunhui Ouyang, Fanggen Lu
    Medicine.2020; 99(3): e18764.     CrossRef
  • Microbes as Master Immunomodulators: Immunopathology, Cancer and Personalized Immunotherapies
    Joana R. Lérias, Georgia Paraschoudi, Eric de Sousa, João Martins, Carolina Condeço, Nuno Figueiredo, Carlos Carvalho, Ernest Dodoo, Mireia Castillo-Martin, Antonio Beltrán, Dário Ligeiro, Martin Rao, Alimuddin Zumla, Markus Maeurer
    Frontiers in Cell and Developmental Biology.2020;[Epub]     CrossRef
  • Epstein Barr Virus-associated Pediatric Neoplasms
    Mozhgan Hashemieh, Fariba Shirvani
    Archives of Pediatric Infectious Diseases.2020;[Epub]     CrossRef
  • Novel IRF8 and PD-L1 molecular aberrations in systemic EBV-positive T-cell lymphoma of childhood
    Atif Saleem, Rohan Joshi, Li Lei, Lhara Lezama, Shyam S. Raghavan, Nastaran Neishaboori, Mohana Roy, Joe Schroers-Martin, Gregory W. Charville, Christian Kunder, Brent Tan, Beth A. Martin, Yasodha Natkunam
    Human Pathology: Case Reports.2020; 19: 200356.     CrossRef
  • Fatal SARS-CoV-2 coinfection in course of EBV-associated lymphoproliferative disease
    Luca Roncati, Beatrice Lusenti, Vincenzo Nasillo, Antonio Manenti
    Annals of Hematology.2020; 99(8): 1945.     CrossRef
  • Epstein-Barr Virus and the Eye
    Emmett T. Cunningham, Manfred Zierhut
    Ocular Immunology and Inflammation.2020; 28(4): 533.     CrossRef
  • An atypical systemic form of chronic active EBV infection
    Neha Gupta, Adam Bagg
    Leukemia & Lymphoma.2020; 61(12): 3030.     CrossRef
  • A Shared TCR Bias toward an Immunogenic EBV Epitope Dominates in HLA-B*07:02–Expressing Individuals
    Louise C. Rowntree, Thi H. O. Nguyen, Carine Farenc, Hanim Halim, Luca Hensen, Jamie Rossjohn, Tom C. Kotsimbos, Anthony W. Purcell, Katherine Kedzierska, Stephanie Gras, Nicole A. Mifsud
    The Journal of Immunology.2020; 205(6): 1524.     CrossRef
  • Chronic active Epstein–Barr virus infection manifesting as coronary artery aneurysm and uveitis
    Haijuan Xiao, Bing Hu, Rongmu Luo, Huili Hu, Junmei Zhang, Weiying Kuang, Rui Zhang, Li Li, Gang Liu
    Virology Journal.2020;[Epub]     CrossRef
  • Epstein-Barr Virus (EBV)-induced B-cell Lymphoproliferative Disorder Mimicking the Recurrence of EBV-associated Hemophagocytic Lymphohistiocytosis
    Yuki Yatsushiro, Takuro Nishikawa, Aki Saito, Yozo Nakazawa, Ken-Ichi Imadome, Shunsuke Nakagawa, Yuichi Kodama, Yasuhiro Okamoto, Hirokazu Kanegane, Yoshifumi Kawano
    Journal of Pediatric Hematology/Oncology.2019; 41(1): e44.     CrossRef
  • Epstein-Barr Virus (EBV)-Related Lymphoproliferative Disorders in Ataxia Telangiectasia: Does ATM Regulate EBV Life Cycle?
    Moussab Tatfi, Olivier Hermine, Felipe Suarez
    Frontiers in Immunology.2019;[Epub]     CrossRef
  • The factors associated with the early diagnosis of nasal NK/T-cell lymphoma with prominent ocular symptoms and general nasal NKTL
    Zhen zhen Hu, Ying Wang
    American Journal of Otolaryngology.2019; 40(3): 353.     CrossRef
  • Unusual lymphoid malignancy and treatment response in two children with Down syndrome
    Ashley Geerlinks, Jennifer Keis, Bo Ngan, Amer Shammas, Reza Vali, Johann Hitzler
    Pediatric Blood & Cancer.2019;[Epub]     CrossRef
  • Extreme Peripheral Blood Plasmacytosis Mimicking Plasma Cell Leukemia as a Presenting Feature of Angioimmunoblastic T-Cell Lymphoma (AITL)
    Kelsey Sokol, Saritha Kartan, William T. Johnson, Onder Alpdogan, Neda Nikbakht, Bradley M. Haverkos, Jerald Gong, Pierluigi Porcu
    Frontiers in Oncology.2019;[Epub]     CrossRef
  • High-Throughput Sequence Analysis of Peripheral T-Cell Lymphomas Indicates Subtype-Specific Viral Gene Expression Patterns and Immune Cell Microenvironments
    Hani Nakhoul, Zhen Lin, Xia Wang, Claire Roberts, Yan Dong, Erik Flemington, Blossom Damania
    mSphere.2019;[Epub]     CrossRef
  • Quercetin Interrupts the Positive Feedback Loop Between STAT3 and IL-6, Promotes Autophagy, and Reduces ROS, Preventing EBV-Driven B Cell Immortalization
    Granato, Gilardini Montani, Zompetta, Santarelli, Gonnella, Romeo, D’Orazi, Faggioni, Cirone
    Biomolecules.2019; 9(9): 482.     CrossRef
  • Diffuse Large B-Cell Lymphoma Arising within Ileal Neobladder: An Expanding Spectrum of Diffuse Large B-Cell Lymphoma Associated with Chronic Inflammation
    Hyekyung Lee, Hyunbin Shin, Nae Yu Kim, Hyun Sik Park, Jinsung Park
    Cancer Research and Treatment.2019; 51(4): 1666.     CrossRef
  • EBV-associated lymphoproliferative disorder involving the gastrointestinal tract which mimic IBD in immunocompetent patients: case reports and literature review
    Yanhua Zhou, Yanlin Zhang, Haiying Zhao, Xuan Cui, Yongqiu Wei, Yongdong Wu, Shutian Zhang, Ye Zong
    International Journal of Colorectal Disease.2019; 34(11): 1989.     CrossRef
  • Mechanistic Insights into Chemoresistance Mediated by Oncogenic Viruses in Lymphomas
    Jungang Chen, Samantha Kendrick, Zhiqiang Qin
    Viruses.2019; 11(12): 1161.     CrossRef
  • Rapidly Fatal Encephalitis Associated with Atypical Lymphoid Proliferations of the Basal Ganglia Subsequent to Aneurysmal Subarachnoid Hemorrhage
    Ayesha Kar, Evin L. Guilliams, Joshua A. Cuoco, Eric A. Marvin
    Clinics and Practice.2019; 9(4): 1187.     CrossRef
  • Clinicopathologic features of adult EBV-associated B-cell lymphoproliferative disease
    Sonja Wörner, Hans-Konrad Mueller-Hermelink, Hans-Ullrich Voelker
    Pathology - Research and Practice.2018; 214(2): 207.     CrossRef
  • Primary Intestinal Epstein–Barr Virus-associated Natural Killer/T-cell Lymphoproliferative Disorder: A Disease Mimicking Inflammatory Bowel Disease
    Zhujun Wang, Wenyan Zhang, Chengxin Luo, Min Zhu, Yu Zhen, Jingxi Mu, Yan Zhang, Renwei Hu, Yufang Wang, Zhonghui Wen, Qin Ouyang, Shuyuan Xiao, Hu Zhang
    Journal of Crohn's and Colitis.2018; 12(8): 896.     CrossRef
  • Downregulation of CD5 and dysregulated CD8+ T‐cell activation
    Taizo Wada
    Pediatrics International.2018; 60(9): 776.     CrossRef
  • Chronic active Epstein-Barr virus infection of T-cell type, systemic form in an African migrant: case report and review of the literature on diagnostics standards and therapeutic options
    Maxi Wass, Marcus Bauer, Roald Pfannes, Kerstin Lorenz, Andreas Odparlik, Lutz P Müller, Claudia Wickenhauser
    BMC Cancer.2018;[Epub]     CrossRef
  • Aggressive B-cell lymphomas in patients with myelofibrosis receiving JAK1/2 inhibitor therapy
    Edit Porpaczy, Sabrina Tripolt, Andrea Hoelbl-Kovacic, Bettina Gisslinger, Zsuzsanna Bago-Horvath, Emilio Casanova-Hevia, Emmanuelle Clappier, Thomas Decker, Sabine Fajmann, Daniela A. Fux, Georg Greiner, Sinan Gueltekin, Gerwin Heller, Harald Herkner, Gr
    Blood.2018; 132(7): 694.     CrossRef
  • Gammaherpesviral infections in patients with immunological disorders
    Anna Żuk-Wasek, Maciej Przybylski, Natalia Żeber, Grażyna Młynarczyk, Tomasz Dzieciątkowski
    Postępy Mikrobiologii - Advancements of Microbiology.2018; 57(2): 145.     CrossRef
  • COMPARATIVE ANALYSIS OF SEROLOGICAL MARKERS OF HERPES VIRUSES AND QUANTITATIVE IMMUNOGLOBULINOPATHIES IN PRIMARY PATIENTS WITH ANGIOIMMUNOBLASTIC T-CELL LYMPHOMA
    N. G. Chernova, D. S. Tihomirov, N. P. Soboleva, S. A. Mariina, Y. V. Sidorova, M. N. Sinitsyna, V. N. Dvirnyk, S. M. Kulikov, T. A. Tupoleva, E. E. Zvonkov
    Problems of Virology.2018; 63(4): 171.     CrossRef
Original Article
Loss of E-cadherin and Acquisition of Vimentin in Epithelial-Mesenchymal Transition are Noble Indicators of Uterine Cervix Cancer Progression
Na-Hye Myong
Korean J Pathol. 2012;46(4):341-348.   Published online August 23, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.4.341
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AbstractAbstract PDF
Background

Epithelial-mesenchymal transition (EMT) has been known to play a key role in the stromal invasion of carcinoma in situ (CIS) lesion. Loss of E-cadherin and acquisition of vimentin are two critical steps in EMT, that are induced by Snail-1 upregulation associated with overexpression of epidermal growth factor receptor (EGFR). However, roles of EMT-related proteins in human cervical tissues have not been fully elucidated. In this study, we investigated the immunoexpressions of EMT-related proteins in CIS, microinvasive squamous cell carcinoma (SCC), and invasive SCC to demonstrate their key roles in tumor progression.

Methods

Eighty one CIS, 17 microinvasive, and 21 invasive SCC cases were immunostained with primary antibodies for Snail-1, EGFR, E-cadherin, and vimentin on paraffin-embedded tissue microarray blocks.

Results

EGFR and Snail-1 proteins were highly expressed but the levels were not significantly different between the three groups. However, loss of E-cadherin and acquisition of vimentin were proven to occur significantly higher in microinvasive and invasive SCC cases than in CIS.

Conclusions

E-cadherin and vimentin were found to be two useful indicators of EMT in evaluating stromal invasion of CIS. However, it was not demonstrated for Snail-1 and EGFR proteins to play any key role in the progression of cervix cancer.

Citations

Citations to this article as recorded by  
  • The effects of low-dose sorafenib on epithelial-mesenchymal transition and multidrug resistance markers in HepG2 cell line
    Yaprak DÖNMEZ ÇAKIL, Zeynep AKBULUT, Gamze DEMİREL, Ranan GÜLHAN, Zeynep OZUNAL
    The European Research Journal.2023; 9(2): 367.     CrossRef
  • Oral Submucous Fibrosis: Etiological Mechanism, Malignant Transformation, Therapeutic Approaches and Targets
    Xiaofeng Qin, Yujie Ning, Liming Zhou, Youming Zhu
    International Journal of Molecular Sciences.2023; 24(5): 4992.     CrossRef
  • Comparative Assessment of E-cadherin’s Expression between the Metastatic and Non-metastatic Oral Squamous Cell Carcinoma: An Immunohistochemical Study
    Sufia Khan, Veda Hegde, Deepti Shrivastava, Mohammed Azamulla, Mohammad Khursheed Alam, Kumar Chandan Srivastava
    Pesquisa Brasileira em Odontopediatria e Clínica Integrada.2023;[Epub]     CrossRef
  • Role of Vimentin and E-cadherin Expression in Premalignant and Malignant Lesions of Oral Cavity
    Sandesh Kumar Gupta, Sunita Agarwal, Shashank Nath Singh, Ritu Sehra, Prem Singh Jat, Pawan Singhal
    Indian Journal of Otolaryngology and Head & Neck Surgery.2022; 74(3): 350.     CrossRef
  • Increased Sphingosine Kinase 1 Expression Is Associated with Poor Prognosis in Human Solid Tumors: A Meta-Analysis
    Chuanmeng Zhang, Chenglin Zhou, Jie Xu, Shanshan Xue, Alexander G Mathioudakis
    Disease Markers.2022; 2022: 1.     CrossRef
  • Current Progress of EMT: A New Direction of Targeted Therapy for Colorectal Cancer with Invasion and Metastasis
    Zhuomin Tan, Wenyan Sun, Ya Li, Xingmeng Jiao, Mingliang Zhu, Junfei Zhang, Chen Qing, Yinnong Jia
    Biomolecules.2022; 12(12): 1723.     CrossRef
  • Study of expression of epithelial cadherin in benign and malignant epithelial lesions of uterine cervix
    Pooja Gupta, Pooja Agarwal, Lalit Kumar, Shikha Prakash, Poonam Yadav
    Journal of Datta Meghe Institute of Medical Sciences University.2022; 17(3): 662.     CrossRef
  • Morphological and molecular characteristics of spheroid formation in HT-29 and Caco-2 colorectal cancer cell lines
    Elmira Gheytanchi, Marzieh Naseri, Feridoun Karimi-Busheri, Fatemeh Atyabi, Ensie Sadat Mirsharif, Mahmood Bozorgmehr, Roya Ghods, Zahra Madjd
    Cancer Cell International.2021;[Epub]     CrossRef
  • MACC1 Is Associated With Epithelial–Mesenchymal Transition and Can Predict Poor Prognosis in Nasopharyngeal Carcinoma
    Hao Cheng, Linxiang Zhou, Yalan Long, Juanjuan Xiang, Longhua Chen
    Frontiers in Oncology.2021;[Epub]     CrossRef
  • Cellular and biomolecular detection based on suspended microchannel resonators
    Juhee Ko, Jaewoo Jeong, Sukbom Son, Jungchul Lee
    Biomedical Engineering Letters.2021; 11(4): 367.     CrossRef
  • Anticancer Properties of Eugenol: A Review
    Ali T. Zari, Talal A. Zari, Khalid Rehman Hakeem
    Molecules.2021; 26(23): 7407.     CrossRef
  • Up-regulated microRNA-33b inhibits epithelial–mesenchymal transition in gallbladder cancer through down-regulating CROCC
    Guohui Xu, Xiaoyong Wei, Qiang Tu, Cuncai Zhou
    Bioscience Reports.2020;[Epub]     CrossRef
  • Independent Validation of Tumor Budding Activity and Cell Nest Size as Determinants of Patient Outcome in Squamous Cell Carcinoma of the Uterine Cervix
    Somaye Y. Zare, Omonigho Aisagbonhi, Farnaz Hasteh, Oluwole Fadare
    American Journal of Surgical Pathology.2020; 44(9): 1151.     CrossRef
  • Study of long non-coding RNA highly upregulated in liver cancer (HULC) in breast cancer: A clinical & in vitro investigation
    ReyhanehRavanbakhsh Gavgani, Esmaeil Babaei, MohammadAli Hosseinpourfeizi, Ashraf Fakhrjou, Vahid Montazeri
    Indian Journal of Medical Research.2020; 152(3): 244.     CrossRef
  • Resveratrol suppresses the growth and metastatic potential of cervical cancer by inhibiting STAT3Tyr705 phosphorylation
    Xiaodong Sun, Qianqian Xu, Lian Zeng, Lixia Xie, Qiang Zhao, Hongxia Xu, Xuanbin Wang, Nan Jiang, Pan Fu, Ming Sang
    Cancer Medicine.2020; 9(22): 8685.     CrossRef
  • microRNA-877 contributes to decreased non-small cell lung cancer cell growth via the PI3K/AKT pathway by targeting tartrate resistant acid phosphatase 5 activity
    Xue Bai, Changjun He, Bicheng Fu, Xianglong Kong, Jianlong Bu, Kaibin Zhu, Wei Zheng, Fucheng Zhou, Boxiong Ni
    Cell Cycle.2020; 19(23): 3260.     CrossRef
  • TRPM4 channel is involved in regulating epithelial to mesenchymal transition, migration, and invasion of prostate cancer cell lines
    Alfredo I. Sagredo, Eduardo A. Sagredo, Victor Pola, César Echeverría, Rodrigo Andaur, Luis Michea, Andrés Stutzin, Felipe Simon, Katherine Marcelain, Ricardo Armisén
    Journal of Cellular Physiology.2019; 234(3): 2037.     CrossRef
  • Overexpression of microRNA‐190 inhibits migration, invasion, epithelial‐mesenchymal transition, and angiogenesis through suppression of protein kinase B‐extracellular signal‐regulated kinase signaling pathway via binding to stanniocalicin 2 in breast canc
    Guiming Sun, Meirong Liu, Hui Han
    Journal of Cellular Physiology.2019; 234(10): 17824.     CrossRef
  • Effect of tumor microenvironment on pathogenesis of the head and neck squamous cell carcinoma: a systematic review
    Barbora Peltanova, Martina Raudenska, Michal Masarik
    Molecular Cancer.2019;[Epub]     CrossRef
  • YY1: A novel therapeutic target for diabetic nephropathy orchestrated renal fibrosis
    Tingting Yang, Fanglin Shu, Hao Yang, Cai Heng, Yi Zhou, Yibing Chen, Xuan Qian, Lei Du, Xia Zhu, Qian Lu, Xiaoxing Yin
    Metabolism.2019; 96: 33.     CrossRef
  • Malignant ascites-derived exosomes promote peritoneal tumor cell dissemination and reveal a distinct miRNA signature in advanced gastric cancer
    Yanting Hu, Changsong Qi, Xiang Liu, Cheng Zhang, Jing Gao, Yi Wu, Jing Yang, Qian Zhao, Jian Li, Xiaojuan Wang, Lin Shen
    Cancer Letters.2019; 457: 142.     CrossRef
  • Silencing of lysyl oxidase‑like 2 inhibits the migration, invasion and epithelial‑to‑mesenchymal transition of renal cell carcinoma cells through the Src/FAK signaling pathway
    Xi Hong, Jian‑Jun Yu
    International Journal of Oncology.2019;[Epub]     CrossRef
  • YY1 Complex Promotes Quaking Expression via Super-Enhancer Binding during EMT of Hepatocellular Carcinoma
    Jingxia Han, Jing Meng, Shuang Chen, Xiaorui Wang, Shan Yin, Qiang Zhang, Huijuan Liu, Rong Qin, Zhongwei Li, Weilong Zhong, Chao Zhang, Heng Zhang, Yuanhao Tang, Tingting Lin, Wanfeng Gao, Xiaoyun Zhang, Lan Yang, Yanrong Liu, Hong-gang Zhou, Tao Sun, Ch
    Cancer Research.2019; 79(7): 1451.     CrossRef
  • E-cadherin: Its dysregulation in carcinogenesis and clinical implications
    Sonia How Ming Wong, Chee Mun Fang, Lay-Hong Chuah, Chee Onn Leong, Siew Ching Ngai
    Critical Reviews in Oncology/Hematology.2018; 121: 11.     CrossRef
  • NDRG2 suppresses proliferation, migration, invasion and epithelial-mesenchymal transition of esophageal cancer cells through regulating the AKT/XIAP signaling pathway
    Cheng-Liang Yang, Xiao-Li Zheng, Ke Ye, Hong Ge, Ya-Nan Sun, Yu-Fei Lu, Qing-Xia Fan
    The International Journal of Biochemistry & Cell Biology.2018; 99: 43.     CrossRef
  • NUSAP1 gene silencing inhibits cell proliferation, migration and invasion through inhibiting DNMT1 gene expression in human colorectal cancer
    Guoda Han, Zhijiang Wei, Haibin Cui, Wei Zhang, Xiaonan Wei, Zhiliang Lu, Xiyong Bai
    Experimental Cell Research.2018; 367(2): 216.     CrossRef
  • Human papillomavirus type 16 E5-mediated upregulation of Met in human keratinocytes
    Matthew L. Scott, David T. Coleman, Kinsey C. Kelly, Jennifer L. Carroll, Brittany Woodby, William K. Songock, James A. Cardelli, Jason M. Bodily
    Virology.2018; 519: 1.     CrossRef
  • Lamin A/C might be involved in the EMT signalling pathway
    Lingkun Zuo, Huanying Zhao, Ronghui Yang, Liyong Wang, Hui Ma, Xiaoxue Xu, Ping Zhou, Lu Kong
    Gene.2018; 663: 51.     CrossRef
  • Potential role of periodontal pathogens in compromising epithelial barrier function by inducing epithelial‐mesenchymal transition
    A. A. Abdulkareem, R. M. Shelton, G. Landini, P. R. Cooper, M. R. Milward
    Journal of Periodontal Research.2018; 53(4): 565.     CrossRef
  • Loss of CAMSAP3 promotes EMT via the modification of microtubule-Akt machinery
    Varisa Pongrakhananon, Onsurang Wattanathamsan, Masatoshi Takeichi, Paninee Chetprayoon, Pithi Chanvorachote
    Journal of Cell Science.2018;[Epub]     CrossRef
  • A Role for βA3/A1-Crystallin in Type 2 EMT of RPE Cells Occurring in Dry Age-Related Macular Degeneration
    Sayan Ghosh, Peng Shang, Hiroto Terasaki, Nadezda Stepicheva, Stacey Hose, Meysam Yazdankhah, Joseph Weiss, Taiji Sakamoto, Imran A. Bhutto, Shuli Xia, J. Samuel Zigler, Ram Kannan, Jiang Qian, James T. Handa, Debasish Sinha
    Investigative Opthalmology & Visual Science.2018; 59(4): AMD104.     CrossRef
  • Nlrp3 Activation Induces Il-18 Synthesis and Affects the Epithelial Barrier Function in Reactive Cholangiocytes
    Luca Maroni, Laura Agostinelli, Stefania Saccomanno, Claudio Pinto, Debora M. Giordano, Chiara Rychlicki, Samuele De Minicis, Luciano Trozzi, Jesus M. Banales, Espen Melum, Tom H. Karlsen, Antonio Benedetti, Gianluca Svegliati Baroni, Marco Marzioni
    The American Journal of Pathology.2017; 187(2): 366.     CrossRef
  • Corepressor metastasis-associated protein 3 modulates epithelial-to-mesenchymal transition and metastasis
    Liang Du, Zhifeng Ning, Fuxing Liu, Hao Zhang
    Chinese Journal of Cancer.2017;[Epub]     CrossRef
  • JNK-associated scattered growth of YD-10B oral squamous carcinoma cells while maintaining the epithelial phenotype
    Gayoung Lee, Hyun-Man Kim
    Biochemical and Biophysical Research Communications.2017; 487(4): 862.     CrossRef
  • Invasive Front Grading and Epithelial-Mesenchymal Transition in Canine Oral and Cutaneous Squamous Cell Carcinomas
    E. Nagamine, K. Hirayama, K. Matsuda, M. Okamoto, T. Ohmachi, K. Uchida, T. Kadosawa, H. Taniyama
    Veterinary Pathology.2017; 54(5): 783.     CrossRef
  • Protein kinase B
    Bhumika Wadhwa, Ubaid Makhdoomi, Ram Vishwakarma, Fayaz Malik
    Anti-Cancer Drugs.2017; 28(6): 569.     CrossRef
  • Correlation analysis between the parameters of contrast-enhanced ultrasonography in evaluating cervical cancer metastasis and expression of E-cadherin
    Xiaolan Lv, Min Hou, Xiaojing Duan
    Oncology Letters.2017; 14(4): 4641.     CrossRef
  • Distribution of telocytes in the corpus and cervix of human uterus: an immunohistochemical study
    Martin Klein, Ladislav Urban, Ivan Deckov, Lubos Danisovic, Stefan Polak, Ludovit Danihel, Ivan Varga
    Biologia.2017; 72(10): 1217.     CrossRef
  • Epithelial–mesenchymal transition, proliferation, and angiogenesis in locally advanced cervical cancer treated with chemoradiotherapy
    Leonardo Rojas‐Puentes, Andrés F. Cardona, Hernán Carranza, Carlos Vargas, Luis F. Jaramillo, Delma Zea, Lucely Cetina, Beatriz Wills, Erika Ruiz‐Garcia, Oscar Arrieta
    Cancer Medicine.2016; 5(8): 1989.     CrossRef
  • Tumor Necrosis Factor-Like Weak Inducer of Apoptosis Accelerates the Progression of Renal Fibrosis in Lupus Nephritis by Activating SMAD and p38 MAPK in TGF-β1 Signaling Pathway
    Zhiqin Liu, Leixi Xue, Zhichun Liu, Jun Huang, Jian Wen, Ji Hu, Lin Bo, Ru Yang
    Mediators of Inflammation.2016; 2016: 1.     CrossRef
  • Identification of SEC62 as a potential marker for 3q amplification and cellular migration in dysplastic cervical lesions
    Maximilian Linxweiler, Florian Bochen, Bernhard Schick, Silke Wemmert, Basel Al Kadah, Markus Greiner, Andrea Hasenfus, Rainer-Maria Bohle, Ingolf Juhasz-Böss, Erich-Franz Solomayer, Zoltan Ferenc Takacs
    BMC Cancer.2016;[Epub]     CrossRef
  • The indicative function of Twist2 and E-cadherin in HPV oncogene-induced epithelial-mesenchymal transition of cervical cancer cells
    YUAN LIU, WENYAN QIAN, JIAWEN ZHANG, YU DONG, CAN SHI, ZHIQIANG LIU, SUFANG WU
    Oncology Reports.2015; 33(2): 639.     CrossRef
  • Prognostic significance of YY1 protein expression and mRNA levels by bioinformatics analysis in human cancers: A therapeutic target
    Benjamin Bonavida, Samantha Kaufhold
    Pharmacology & Therapeutics.2015; 150: 149.     CrossRef
  • Expression of podoplanin and vimentin is correlated with prognosis in esophageal squamous cell carcinoma
    MAKIKO TANAKA, HIROSHI KIJIMA, HIDEO SHIMADA, HIROYASU MAKUUCHI, SOJI OZAWA, SADAKI INOKUCHI
    Molecular Medicine Reports.2015; 12(3): 4029.     CrossRef
  • Podoplanin expression is correlated with the prognosis of lung squamous cell carcinoma
    Yoichiro IKOMA, Hiroshi KIJIMA, Ryota MASUDA, Makiko TANAKA, Sadaki INOKUCHI, Masayuki IWAZAKI
    Biomedical Research.2015; 36(6): 393.     CrossRef
  • Abnormal expression of EMT-related proteins, S100A4, vimentin and E-cadherin, is correlated with clinicopathological features and prognosis in HCC
    Xiaolu Zhai, Huijun Zhu, Wei Wang, Shu Zhang, Yixin Zhang, Guoxin Mao
    Medical Oncology.2014;[Epub]     CrossRef
  • The Clinicopathological Significance of Epithelial Mesenchymal Transition Associated Protein Expression in Head and Neck Squamous Cell Carcinoma
    Kyu Ho Kim, Lucia Kim, Suk Jin Choi, Jee Young Han, Joon Mee Kim, Young Chae Chu, Young-Mo Kim, In Suh Park, Joo Han Lim
    Korean Journal of Pathology.2014; 48(4): 263.     CrossRef
  • Thrombomodulin mediates the migration of cervical cancer cells through the regulation of epithelial–mesenchymal transition biomarkers
    Cheng-Jeng Tai, Chao-Wen Cheng, Hou-Yu Su, Wei-Yu Chen, Chun-Te Wu, Feng-Yen Lin, Chien-Kai Wang, Chen-Jei Tai, Po-Li Wei
    Tumor Biology.2014; 35(1): 47.     CrossRef
  • Role of epithelial to mesenchymal transition proteins in gynecological cancers: pathological and therapeutic perspectives
    Xiao-mei Zhou, Hai Zhang, Xia Han
    Tumor Biology.2014; 35(10): 9523.     CrossRef
  • Normal Fibroblasts Induce E-Cadherin Loss and Increase Lymph Node Metastasis in Gastric Cancer
    Wen Xu, Xinlei Hu, Zhongting Chen, Xiaoping Zheng, Chenjing Zhang, Gang Wang, Yu Chen, Xinglu Zhou, Xiaoxiao Tang, Laisheng Luo, Xiang Xu, Wensheng Pan, Elad Katz
    PLoS ONE.2014; 9(5): e97306.     CrossRef
  • The Culture of Cancer Cell Lines as Tumorspheres Does Not Systematically Result in Cancer Stem Cell Enrichment
    Christophe Y. Calvet, Franck M. André, Lluis M. Mir, Anita B. Hjelmeland
    PLoS ONE.2014; 9(2): e89644.     CrossRef
  • Role of YY1 in the pathogenesis of prostate cancer and correlation with bioinformatic data sets of gene expression
    Vaishali Kashyap, Benjamin Bonavida
    Genes & Cancer.2014; 5(3-4): 71.     CrossRef
  • Expression and Significance of Twist and E-cadherin in Ovarian Cancer Tissues
    Wen-Shuang Wang, Shou-Li Yu, Xing-Sheng Yang, Shu-De Chang, Jian-Qing Hou
    Asian Pacific Journal of Cancer Prevention.2013; 14(2): 669.     CrossRef
  • The glioma-associated oncogene homolog 1 promotes epithelial–mesenchymal transition in human esophageal squamous cell cancer by inhibiting E-cadherin via Snail
    S Min, X Xiaoyan, P Fanghui, W Yamei, Y Xiaoli, W Feng
    Cancer Gene Therapy.2013; 20(7): 379.     CrossRef
  • TACC3 Is Essential for EGF-Mediated EMT in Cervical Cancer
    Geun-Hyoung Ha, Jung-Lye Kim, Eun-Kyoung Yim Breuer, Antimo Migliaccio
    PLoS ONE.2013; 8(8): e70353.     CrossRef
  • Overexpression of E2F1 Promotes Tumor Malignancy And Correlates with TNM Stages in Clear Cell Renal Cell Carcinoma
    Xin Ma, Yu Gao, Yang Fan, Dong Ni, Yu Zhang, Weihao Chen, Peng Zhang, Erlin Song, Qingbo Huang, Qing Ai, Hongzhao Li, Baojun Wang, Tao Zheng, Taoping Shi, Xu Zhang, Hiromu Suzuki
    PLoS ONE.2013; 8(9): e73436.     CrossRef
  • Transforming growth factor-β1 induces bronchial epithelial cells to mesenchymal transition by activating the Snail pathway and promotes airway remodeling in asthma
    ZHAO-CHUAN YANG, MING-JI YI, NI RAN, CHONG WANG, PENG FU, XUE-YING FENG, LEI XU, ZHENG-HAI QU
    Molecular Medicine Reports.2013; 8(6): 1663.     CrossRef
Reviews
Extracellular Vesicles and the Promise of Continuous Liquid Biopsies
Don Armstrong, Derek E. Wildman
J Pathol Transl Med. 2018;52(1):1-8.   Published online January 15, 2018
DOI: https://doi.org/10.4132/jptm.2017.05.21
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AbstractAbstract PDF
The rapid and accurate diagnosis of patients with minimally invasive procedures was once only found in science fiction. However, the discovery of extracellular vesicles (EVs) and their near ubiquity in body fluids, coupled with the advent of inexpensive next generation sequencing techniques and EV purification protocols, promises to make science fiction a reality. Purifying and sequencing the RNA content of EV from routine blood draws and urine samples are likely to enable pathologists and physicians to diagnose and track the progress of diseases in many inaccessible tissues in the near future. Here we present the evolutionary background of EV, summarize the biology of EV formation and cargo selection, and discuss the current barriers to making continuous liquid biopsies through the use of EV a science reality.

Citations

Citations to this article as recorded by  
  • Extracellular Vesicles as Delivery Vehicles for Non-Coding RNAs: Potential Biomarkers for Chronic Liver Diseases
    Arianna Ferro, Gabriele Saccu, Simone Mattivi, Andrea Gaido, Maria Beatriz Herrera Sanchez, Shafiul Haque, Lorenzo Silengo, Fiorella Altruda, Marilena Durazzo, Sharmila Fagoonee
    Biomolecules.2024; 14(3): 277.     CrossRef
  • Autologous Platelet and Extracellular Vesicle-Rich Plasma as Therapeutic Fluid: A Review
    Kaja Troha, Domen Vozel, Matevž Arko, Apolonija Bedina Zavec, Drago Dolinar, Matej Hočevar, Zala Jan, Matic Kisovec, Boštjan Kocjančič, Ljubiša Pađen, Manca Pajnič, Samo Penič, Anna Romolo, Neža Repar, Vesna Spasovski, Nejc Steiner, Vid Šuštar, Aleš Iglič
    International Journal of Molecular Sciences.2023; 24(4): 3420.     CrossRef
  • Liquid Biopsies, Novel Approaches and Future Directions
    Athanasios Armakolas, Maria Kotsari, John Koskinas
    Cancers.2023; 15(5): 1579.     CrossRef
  • Proteomic Signature of Extracellular Vesicles Associated with Colorectal Cancer
    Natalia Soloveva, Svetlana Novikova, Tatiana Farafonova, Olga Tikhonova, Victor Zgoda
    Molecules.2023; 28(10): 4227.     CrossRef
  • Engineering extracellular vesicles for Alzheimer's disease: An emerging cell‐free approach for earlier diagnosis and treatment
    Sabrina Valentina Lazar, Sirjan Mor, David Wang, Leora Goldbloom‐Helzner, Kaitlin Clark, Dake Hao, Diana Lee Farmer, Aijun Wang
    WIREs Mechanisms of Disease.2022;[Epub]     CrossRef
  • Engineered exosomes as a natural nanoplatform for cancer targeted delivery of metal-based drugs
    Tao Feng, Johannes Karges, Xinxing Liao, Liangnian Ji, Hui Chao
    Coordination Chemistry Reviews.2022; 454: 214325.     CrossRef
  • Storage conditions determine the characteristics of red blood cell derived extracellular vesicles
    Tímea Bebesi, Diána Kitka, Anikó Gaál, Imola Csilla Szigyártó, Róbert Deák, Tamás Beke-Somfai, Kitti Koprivanacz, Tünde Juhász, Attila Bóta, Zoltán Varga, Judith Mihály
    Scientific Reports.2022;[Epub]     CrossRef
  • Novel Exosome Biomarker Candidates for Alzheimer’s Disease Unravelled Through Mass Spectrometry Analysis
    Tânia Soares Martins, Rui Marçalo, Cristóvão B. da Cruz e Silva, Dário Trindade, José Catita, Francisco Amado, Tânia Melo, Ilka Martins Rosa, Jonathan Vogelgsang, Jens Wiltfang, Odete A. B. da Cruz e Silva, Ana Gabriela Henriques
    Molecular Neurobiology.2022; 59(5): 2838.     CrossRef
  • Saliva Based Liquid Biopsies in Head and Neck Cancer: How Far Are We From the Clinic?
    Aditi Patel, Shanaya Patel, Parina Patel, Vivek Tanavde
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Incidental Detection of Maternal Malignancy by Fetal Cell-Free DNA Screening
    Britton D. Rink, Blair K. Stevens, Mary E. Norton
    Obstetrics & Gynecology.2022; 140(1): 121.     CrossRef
  • Investigating the consistency of extracellular vesicle production from breast cancer subtypes using CELLine adherent bioreactors
    Colin L. Hisey, Anastasiia Artuyants, George Guo, Vanessa Chang, Gabrielle Reshef, Martin Middleditch, Bincy Jacob, Lawrence W. Chamley, Cherie Blenkiron
    Journal of Extracellular Biology.2022;[Epub]     CrossRef
  • Diagnostic and therapeutic potential of exosomes in Alzheimer’s disease
    Tânia Soares Martins, Dário Trindade, Margarida Vaz, Inês Campelo, Martim Almeida, Guilherme Trigo, Odete A. B. da Cruz e Silva, Ana Gabriela Henriques
    Journal of Neurochemistry.2021; 156(2): 162.     CrossRef
  • Composition of the whole transcriptome in the human plasma: Cellular source and modification by aging
    Tapio Nevalainen, Arttu Autio, Maija Puhka, Marja Jylhä, Mikko Hurme
    Experimental Gerontology.2021; 143: 111119.     CrossRef
  • Extracellular vesicles in cancer diagnostics and therapeutics
    Adeeb Shehzad, Salman Ul Islam, Raheem Shahzad, Salman Khan, Young Sup Lee
    Pharmacology & Therapeutics.2021; 223: 107806.     CrossRef
  • Elevated complement mediator levels in endothelial-derived plasma exosomes implicate endothelial innate inflammation in diminished brain function of aging humans
    Fanny M. Elahi, Danielle Harvey, Marie Altendahl, Nivetha Brathaban, Nicole Fernandes, Kaitlin B. Casaletto, Adam M. Staffaroni, Pauline Maillard, Jason D. Hinman, Bruce L. Miller, Charles DeCarli, Joel H. Kramer, Edward J. Goetzl
    Scientific Reports.2021;[Epub]     CrossRef
  • Extracellular Vesicles as Mediators of Cancer Disease and as Nanosystems in Theranostic Applications
    Renato Burgos-Ravanal, América Campos, Magda C. Díaz-Vesga, María Fernanda González, Daniela León, Lorena Lobos-González, Lisette Leyton, Marcelo J. Kogan, Andrew F. G. Quest
    Cancers.2021; 13(13): 3324.     CrossRef
  • Extracellular Vesicles as Biomarkers and Therapeutic Tools: From Pre-Clinical to Clinical Applications
    Maria Chiara Ciferri, Rodolfo Quarto, Roberta Tasso
    Biology.2021; 10(5): 359.     CrossRef
  • Unsupervised Machine Learning‐Based Clustering of Nanosized Fluorescent Extracellular Vesicles
    Sören Kuypers, Nick Smisdom, Isabel Pintelon, Jean‐Pierre Timmermans, Marcel Ameloot, Luc Michiels, Jelle Hendrix, Baharak Hosseinkhani
    Small.2021;[Epub]     CrossRef
  • A multiparametric extraction method for Vn96-isolated plasma extracellular vesicles and cell-free DNA that enables multi-omic profiling
    Jeremy W. Roy, Catherine A. Taylor, Annie P. Beauregard, Surendar R. Dhadi, D. Craig Ayre, Sheena Fry, Simi Chacko, Gabriel Wajnberg, Andrew P. Joy, Ngoc-Nu Mai-Thi, Nicolas Crapoulet, David A. Barnett, Anirban Ghosh, Stephen M. Lewis, Rodney J. Ouellette
    Scientific Reports.2021;[Epub]     CrossRef
  • The distinct roles of exosomes in tumor-stroma crosstalk within gastric tumor microenvironment
    Hanyu Zhang, Min Yang, Xu Wu, Qianxiu Li, Xin Li, Yueshui Zhao, Fukuan Du, Yu Chen, Zhigui Wu, Zhangang Xiao, Jing Shen, Qinglian Wen, Wei Hu, Chi Hin Cho, Meijuan Chen, Yejiang Zhou, Mingxing Li
    Pharmacological Research.2021; 171: 105785.     CrossRef
  • Exosomes in Alzheimer’s Disease: From Being Pathological Players to Potential Diagnostics and Therapeutics
    Hagar M. Soliman, Ghada A. Ghonaim, Shaza M. Gharib, Hitesh Chopra, Aya K. Farag, Mohamed H. Hassanin, Abdalrazeq Nagah, Mahmoud Emad-Eldin, Nevertary E. Hashem, Galal Yahya, Sherif E. Emam, Abdalla E. A. Hassan, Mohamed S. Attia
    International Journal of Molecular Sciences.2021; 22(19): 10794.     CrossRef
  • Mitochondrial Quality Control in Cardiac-Conditioning Strategies against Ischemia-Reperfusion Injury
    Wylly Ramsés García-Niño, Cecilia Zazueta, Mabel Buelna-Chontal, Alejandro Silva-Palacios
    Life.2021; 11(11): 1123.     CrossRef
  • Proteomic Profiling of Exosomes Derived from Plasma of HIV-Infected Alcohol Drinkers and Cigarette Smokers
    Sunitha Kodidela, Yujie Wang, Benjamin J. Patters, Yuqing Gong, Namita Sinha, Sabina Ranjit, Kelli Gerth, Sanjana Haque, Theodore Cory, Carole McArthur, Anil Kumar, Jim Y. Wan, Santosh Kumar
    Journal of Neuroimmune Pharmacology.2020; 15(3): 501.     CrossRef
  • Promising Applications of AIEgens in Animal Models
    Bairong He, Bo Situ, Zujin Zhao, Lei Zheng
    Small Methods.2020;[Epub]     CrossRef
  • Extracellular Vesicles Derived Human-miRNAs Modulate the Immune System in Type 1 Diabetes
    Tine Tesovnik, Jernej Kovač, Katka Pohar, Samo Hudoklin, Klemen Dovč, Nataša Bratina, Katarina Trebušak Podkrajšek, Maruša Debeljak, Peter Veranič, Emanuele Bosi, Lorenzo Piemonti, Alojz Ihan, Tadej Battelino
    Frontiers in Cell and Developmental Biology.2020;[Epub]     CrossRef
  • The Role of Extracellular Vesicles in the Hallmarks of Cancer and Drug Resistance
    Cristina P. R. Xavier, Hugo R. Caires, Mélanie A. G. Barbosa, Rui Bergantim, José E. Guimarães, M. Helena Vasconcelos
    Cells.2020; 9(5): 1141.     CrossRef
  • Connexin-46 Contained in Extracellular Vesicles Enhance Malignancy Features in Breast Cancer Cells
    Rodrigo A. Acuña, Manuel Varas-Godoy, Viviana M. Berthoud, Ivan E. Alfaro, Mauricio A. Retamal
    Biomolecules.2020; 10(5): 676.     CrossRef
  • Mentalexo approach for diagnosis of psychiatric disorders
    Ahmet Topuzoğlu, Can Ilgın
    Medical Hypotheses.2020; 143: 109823.     CrossRef
  • Reagent-free total protein quantification of intact extracellular vesicles by attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy
    Veronika Szentirmai, András Wacha, Csaba Németh, Diána Kitka, Anita Rácz, Károly Héberger, Judith Mihály, Zoltán Varga
    Analytical and Bioanalytical Chemistry.2020; 412(19): 4619.     CrossRef
  • Urinary Biomarkers in Bladder Cancer: Where Do We Stand and Potential Role of Extracellular Vesicles
    Manuel Castanheira de Oliveira, Hugo R. Caires, Maria J. Oliveira, Avelino Fraga, M. Helena Vasconcelos, Ricardo Ribeiro
    Cancers.2020; 12(6): 1400.     CrossRef
  • (Sub)populations of extracellular vesicles released by TNF‐α –triggered human endothelial cells promote vascular inflammation and monocyte migration
    Baharak Hosseinkhani, Nynke M.S. van den Akker, Daniel G.M. Molin, Luc Michiels
    Journal of Extracellular Vesicles.2020;[Epub]     CrossRef
  • Liquid biopsy using extracellular vesicle–derived DNA in lung adenocarcinoma
    In Ae Kim, Jae Young Hur, Hee Joung Kim, Seung Eun Lee, Wan Seop Kim, Kye Young Lee
    Journal of Pathology and Translational Medicine.2020; 54(6): 453.     CrossRef
  • Mitochondrial RNA in Alzheimer’s Disease Circulating Extracellular Vesicles
    Kyoung Mi Kim, Qiong Meng, Olivia Perez de Acha, Maja Mustapic, Aiwu Cheng, Erden Eren, Gautam Kundu, Yulan Piao, Rachel Munk, William H. Wood, Supriyo De, Ji Heon Noh, Michael Delannoy, Lesley Cheng, Kotb Abdelmohsen, Dimitrios Kapogiannis, Myriam Gorosp
    Frontiers in Cell and Developmental Biology.2020;[Epub]     CrossRef
  • Challenges in Biomaterial-Based Drug Delivery Approach for the Treatment of Neurodegenerative Diseases: Opportunities for Extracellular Vesicles
    Asit Kumar, Lina Zhou, Kaining Zhi, Babatunde Raji, Shelby Pernell, Erene Tadrous, Sunitha Kodidela, Anantha Nookala, Harry Kochat, Santosh Kumar
    International Journal of Molecular Sciences.2020; 22(1): 138.     CrossRef
  • Tumor-specific genetic aberrations in cell-free DNA of gastroesophageal cancer patients
    Kristina Magaard Koldby, Michael Bau Mortensen, Sönke Detlefsen, Per Pfeiffer, Mads Thomassen, Torben A. Kruse
    Journal of Gastroenterology.2019; 54(2): 108.     CrossRef
  • Raman tweezers microspectroscopy of circa 100 nm extracellular vesicles
    Sergei G. Kruglik, Félix Royo, Jean-Michel Guigner, Laura Palomo, Olivier Seksek, Pierre-Yves Turpin, Irène Tatischeff, Juan M. Falcón-Pérez
    Nanoscale.2019; 11(4): 1661.     CrossRef
  • Application of Extracellular Vesicles Proteomics to Cardiovascular Disease: Guidelines, Data Analysis, and Future Perspectives
    Maria N. Barrachina, Beatriz Calderón‐Cruz, Lucía Fernandez‐Rocca, Ángel García
    PROTEOMICS.2019;[Epub]     CrossRef
  • Prognostic Role of S100A8 and S100A9 Protein Expressions in Non-small Cell Carcinoma of the Lung
    Hyun Min Koh, Hyo Jung An, Gyung Hyuck Ko, Jeong Hee Lee, Jong Sil Lee, Dong Chul Kim, Jung Wook Yang, Min Hye Kim, Sung Hwan Kim, Kyung Nyeo Jeon, Gyeong-Won Lee, Se Min Jang, Dae Hyun Song
    Journal of Pathology and Translational Medicine.2019; 53(1): 13.     CrossRef
  • High-fidelity probing of the structure and heterogeneity of extracellular vesicles by resonance-enhanced atomic force microscopy infrared spectroscopy
    Sally Yunsun Kim, Dipesh Khanal, Bill Kalionis, Wojciech Chrzanowski
    Nature Protocols.2019; 14(2): 576.     CrossRef
  • Liquid Biopsies in Cancer Diagnosis, Monitoring, and Prognosis
    Gabriele De Rubis, Sabna Rajeev Krishnan, Mary Bebawy
    Trends in Pharmacological Sciences.2019; 40(3): 172.     CrossRef
  • Intercellular Vesicular Transfer by Exosomes, Microparticles and Oncosomes - Implications for Cancer Biology and Treatments
    Ritu Jaiswal, Lisa M. Sedger
    Frontiers in Oncology.2019;[Epub]     CrossRef
  • Dictyostelium: A Model for Studying the Extracellular Vesicle Messengers Involved in Human Health and Disease
    Irène Tatischeff
    Cells.2019; 8(3): 225.     CrossRef
  • Extracellular Vesicles as Diagnostics and Therapeutics for Structural Epilepsies
    Jenni Karttunen, Mette Heiskanen, Anssi Lipponen, David Poulsen, Asla Pitkänen
    International Journal of Molecular Sciences.2019; 20(6): 1259.     CrossRef
  • Post-translational modification and protein sorting to small extracellular vesicles including exosomes by ubiquitin and UBLs
    Hiroshi Ageta, Kunihiro Tsuchida
    Cellular and Molecular Life Sciences.2019; 76(24): 4829.     CrossRef
  • Exosome release and cargo in Down syndrome
    Eric D. Hamlett, Angela LaRosa, Elliott J. Mufson, Juan Fortea, Aurélie Ledreux, Ann‐Charlotte Granholm
    Developmental Neurobiology.2019; 79(7): 639.     CrossRef
  • Exosomes in specific fractions of the boar ejaculate contain CD44: A marker for epididymosomes?
    Manuel Alvarez-Rodriguez, Stefan A. Ljunggren, Helen Karlsson, Heriberto Rodriguez-Martinez
    Theriogenology.2019; 140: 143.     CrossRef
  • A review on protein markers of exosome from different bio-resources and the antibodies used for characterization
    Fengyan Deng, Josh Miller
    Journal of Histotechnology.2019; 42(4): 226.     CrossRef
  • Tangential Flow Microfluidics for the Capture and Release of Nanoparticles and Extracellular Vesicles on Conventional and Ultrathin Membranes
    Mehdi Dehghani, Kilean Lucas, Jonathan Flax, James McGrath, Thomas Gaborski
    Advanced Materials Technologies.2019;[Epub]     CrossRef
  • Lipidomic analysis of urinary exosomes from hereditary α‐tryptasemia patients and healthy volunteers
    Sarah C. Glover, Mohammad‐Zaman Nouri, Kubra M. Tuna, Lybil B. Mendoza Alvarez, Lisa K. Ryan, James F. Shirley, Ying Tang, Nancy D. Denslow, Abdel A. Alli
    FASEB BioAdvances.2019; 1(10): 624.     CrossRef
  • Novel Epigenetic Biomarkers in Pregnancy-Related Disorders and Cancers
    Karin-Kujundzic, Sola, Predavec, Potkonjak, Somen, Mioc, Serman, Vranic, Serman
    Cells.2019; 8(11): 1459.     CrossRef
  • The Potential Clinical Implications of Circulating Tumor Cells and Circulating Tumor Microemboli in Gastric Cancer
    Emne A. Abdallah, Alexcia C. Braun, Bianca C.T.C.P. Flores, Laís Senda, Ana Cláudia Urvanegia, Vinicius Calsavara, Victor Hugo Fonseca de Jesus, Maria Fernanda Arruda Almeida, Maria Dirlei Begnami, Felipe J.F. Coimbra, Wilson Luiz da Costa, Diana Noronha
    The Oncologist.2019; 24(9): e854.     CrossRef
  • Role of tumor‑derived extracellular vesicles in cancer progression and their clinical applications (Review)
    Fuhao Qiao, Peng Pan, Jiaping Yan, Jing Sun, Yan Zong, Zhiyong Wu, Xiaoqin Lu, Na Chen, Rui Mi, Yongbin Ma, Yuan Ji
    International Journal of Oncology.2019;[Epub]     CrossRef
  • Circulating tumor DNA – Current state of play and future perspectives
    Gabriele De Rubis, Sabna Rajeev Krishnan, Mary Bebawy
    Pharmacological Research.2018; 136: 35.     CrossRef
  • “Liquid Biopsy” of White Matter Hyperintensity in Functionally Normal Elders
    Fanny M. Elahi, Kaitlin B. Casaletto, Marie Altendahl, Adam M. Staffaroni, Evan Fletcher, Teresa J. Filshtein, Maria M. Glymour, Bruce L. Miller, Jason D. Hinman, Charles DeCarli, Edward J. Goetzl, Joel H. Kramer
    Frontiers in Aging Neuroscience.2018;[Epub]     CrossRef
  • The role of exosomal transport of viral agents in persistent HIV pathogenesis
    Benjamin J. Patters, Santosh Kumar
    Retrovirology.2018;[Epub]     CrossRef
Tumor immune response and immunotherapy in gastric cancer
Yoonjin Kwak, An Na Seo, Hee Eun Lee, Hye Seung Lee
J Pathol Transl Med. 2020;54(1):20-33.   Published online November 1, 2019
DOI: https://doi.org/10.4132/jptm.2019.10.08
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AbstractAbstract PDF
Remarkable developments in immuno-oncology have changed the landscape of gastric cancer (GC) treatment. Because immunotherapy intervenes with tumor immune response rather than directly targeting tumor cells, it is important to develop a greater understanding of tumor immunity. This review paper summarizes the tumor immune reaction and immune escape mechanisms while focusing on the role of T cells and their co-inhibitory signals, such as the immune checkpoint molecules programmed death-1 and programmed deathligand 1 (PD-L1). This paper also describes past clinical trials of immunotherapy for patients with GC and details their clinical implications. Strong predictive markers are essential to improve response to immunotherapy. Microsatellite instability, Epstein-Barr virus, PD-L1 expression, and tumor mutational burden are now regarded as potent predictive markers for immunotherapy in patients with GC. Novel immunotherapy and combination therapy targeting new immune checkpoint molecules such as lymphocyte-activation gene 3, T cell immunoglobulin, and mucin domain containing-3, and indoleamine 2,3-dioxygenase have been suggested, and trials are ongoing to evaluate their safety and efficacy. Immunotherapy is an important treatment option for patients with GC and has great potential for improving patient outcome, and further research in immuno-oncology should be carried out.

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  • Ubiquilin-4 induces immune escape in gastric cancer by activating the notch signaling pathway
    Quan Jiang, Hao Chen, Shixin Zhou, Tao Zhu, Wenshuai Liu, Hao Wu, Yong Zhang, Fenglin Liu, Yihong Sun
    Cellular Oncology.2024; 47(1): 303.     CrossRef
  • Expression and prognostic value of APOBEC2 in gastric adenocarcinoma and its association with tumor-infiltrating immune cells
    Lipan Wei, Xiuqian Wu, Lan Wang, Ling Chen, Xuejun Wu, Tiantian Song, Yuanyuan Wang, Wenjun Chang, Aizhen Guo, Yongdong Niu, Haihua Huang
    BMC Cancer.2024;[Epub]     CrossRef
  • Identification and characterization of CLEC11A and its derived immune signature in gastric cancer
    Qing Zheng, Zhenqi Gong, Baizhi Li, Runzi Cheng, Weican Luo, Cong Huang, Huaiming Wang
    Frontiers in Immunology.2024;[Epub]     CrossRef
  • Computed tomography-detected extramural venous invasion-related gene signature: a potential negative biomarker of immune checkpoint inhibitor treatment in patients with gastric cancer
    Hao Yang, Xinyi Gou, Caizhen Feng, Yinli Zhang, Fan Chai, Nan Hong, Yingjiang Ye, Yi Wang, Bo Gao, Jin Cheng
    Journal of Translational Medicine.2023;[Epub]     CrossRef
  • A standardized pathology report for gastric cancer: 2nd edition
    Young Soo Park, Myeong-Cherl Kook, Baek-hui Kim, Hye Seung Lee, Dong-Wook Kang, Mi-Jin Gu, Ok Ran Shin, Younghee Choi, Wonae Lee, Hyunki Kim, In Hye Song, Kyoung-Mee Kim, Hee Sung Kim, Guhyun Kang, Do Youn Park, So-Young Jin, Joon Mee Kim, Yoon Jung Choi,
    Journal of Pathology and Translational Medicine.2023; 57(1): 1.     CrossRef
  • A Standardized Pathology Report for Gastric Cancer: 2nd Edition
    Young Soo Park, Myeong-Cherl Kook, Baek-hui Kim, Hye Seung Lee, Dong-Wook Kang, Mi-Jin Gu, Ok Ran Shin, Younghee Choi, Wonae Lee, Hyunki Kim, In Hye Song, Kyoung-Mee Kim, Hee Sung Kim, Guhyun Kang, Do Youn Park, So-Young Jin, Joon Mee Kim, Yoon Jung Choi,
    Journal of Gastric Cancer.2023; 23(1): 107.     CrossRef
  • Korean Practice Guidelines for Gastric Cancer 2022: An Evidence-based, Multidisciplinary Approach
    Tae-Han Kim, In-Ho Kim, Seung Joo Kang, Miyoung Choi, Baek-Hui Kim, Bang Wool Eom, Bum Jun Kim, Byung-Hoon Min, Chang In Choi, Cheol Min Shin, Chung Hyun Tae, Chung sik Gong, Dong Jin Kim, Arthur Eung-Hyuck Cho, Eun Jeong Gong, Geum Jong Song, Hyeon-Su Im
    Journal of Gastric Cancer.2023; 23(1): 3.     CrossRef
  • Could Toll-like Receptor 2 Serve as Biomarker to Detect Advanced Gastric Cancer?
    Marek Majewski, Kamil Torres, Paulina Mertowska, Sebastian Mertowski, Izabela Korona-Głowniak, Jan Korulczyk, Witold Zgodziński, Ewelina Grywalska
    International Journal of Molecular Sciences.2023; 24(6): 5824.     CrossRef
  • Research Progress of Immunotherapy for Gastric Cancer
    Zhipeng Zhang, Ningning Liu, Mingyu Sun
    Technology in Cancer Research & Treatment.2023; 22: 153303382211505.     CrossRef
  • Case Report: A rare synchronous multiple gastric carcinoma achieved progression-free disease through NGS-guided serial treatment
    Xinyi Shao, Jin Yin, Di Wang, Erjiong Huang, Yini Zhang, Jiani C. Yin, Chen Huang, Hao Wu, Xiaoli Wu
    Frontiers in Oncology.2023;[Epub]     CrossRef
  • Artificial Intelligence-Enabled Gastric Cancer Interpretations
    Mustafa Yousif, Liron Pantanowitz
    Surgical Pathology Clinics.2023; 16(4): 673.     CrossRef
  • The Optimal Tumor Mutational Burden Cutoff Value as a Novel Marker for Predicting the Efficacy of Programmed Cell Death-1 Checkpoint Inhibitors in Advanced Gastric Cancer
    Jae Yeon Jang, Youngkyung Jeon, Sun Young Jeong, Sung Hee Lim, Won Ki Kang, Jeeyun Lee, Seung Tae Kim
    Journal of Gastric Cancer.2023; 23(3): 476.     CrossRef
  • Biomarkers for Predicting Response to Personalized Immunotherapy in Gastric Cancer
    Moonsik Kim, Ji Yun Jeong, An Na Seo
    Diagnostics.2023; 13(17): 2782.     CrossRef
  • The Prognostic Value of the Prognostic Nutritional Index in Patients with Advanced or Metastatic Gastric Cancer Treated with Immunotherapy
    Yuting Pan, Yue Ma, Guanghai Dai
    Nutrients.2023; 15(19): 4290.     CrossRef
  • Molecular classification of gastric cancer predicts survival in patients undergoing radical gastrectomy based on project HOPE
    Kenichiro Furukawa, Keiichi Hatakeyama, Masanori Terashima, Takeshi Nagashima, Kenichi Urakami, Keiichi Ohshima, Akifumi Notsu, Takashi Sugino, Taisuke Yagi, Keiichi Fujiya, Satoshi Kamiya, Makoto Hikage, Yutaka Tanizawa, Etsuro Bando, Yae Kanai, Yasuto A
    Gastric Cancer.2022; 25(1): 138.     CrossRef
  • Immunotherapy for gastric cancer: a 2021 update
    Christo Kole, Nikolaos Charalampakis, Sergios Tsakatikas, Nikolaos-Iasonas Kouris, George Papaxoinis, Michalis V Karamouzis, Anna Koumarianou, Dimitrios Schizas
    Immunotherapy.2022; 14(1): 41.     CrossRef
  • The immune microenvironment in gastric adenocarcinoma
    Yana Zavros, Juanita L. Merchant
    Nature Reviews Gastroenterology & Hepatology.2022; 19(7): 451.     CrossRef
  • Immunomodulation by Gut Microbiome on Gastrointestinal Cancers: Focusing on Colorectal Cancer
    Raghad Khalid AL-Ishaq, Lenka Koklesova, Peter Kubatka, Dietrich Büsselberg
    Cancers.2022; 14(9): 2140.     CrossRef
  • An Immunity-Associated lncRNA Signature for Predicting Prognosis in Gastric Adenocarcinoma
    Xiaowen Zhao, Pingfan Wu, Dongling Liu, Changtian Li, Ling Xue, Zhe Liu, Meng Zhu, Jie Yang, Ziyi Chen, Yaling Li, Yali She, Kathiravan Srinivasan
    Journal of Healthcare Engineering.2022; 2022: 1.     CrossRef
  • RNA modification writers influence tumor microenvironment in gastric cancer and prospects of targeted drug therapy
    Peng Song, Sheng Zhou, Xiaoyang Qi, Yuwen Jiao, Yu Gong, Jie Zhao, Haojun Yang, Zhifen Qian, Jun Qian, Liming Tang
    Journal of Bioinformatics and Computational Biology.2022;[Epub]     CrossRef
  • Identification of the three subtypes and the prognostic characteristics of stomach adenocarcinoma: analysis of the hypoxia-related long non-coding RNAs
    Zehua Fan, Yanqun Wang, Rong Niu
    Functional & Integrative Genomics.2022; 22(5): 919.     CrossRef
  • Complete Response of High Microsatellite Instability Gastric Cancer and Synchronous Microsatellite Stability Rectal Cancer
    Zachary E Hunzeker, Pooja Bhakta, Sindusha R Gudipally, Sri Bharathi Kavuri, Rohit Venkatesan, Chukwuyejulumafor Nwanze
    Cureus.2022;[Epub]     CrossRef
  • Immune Profiling in Gastric Cancer Reveals the Dynamic Landscape of Immune Signature Underlying Tumor Progression
    Yuhan Wei, Jianwei Zhang, Xueke Fan, Zhi Zheng, Xiaoyue Jiang, Dexi Chen, Yuting Lu, Yingrui Li, Miao Wang, Min Hu, Qi Du, Liuting Yang, Hongzhong Li, Yi Xiao, Yongfu Li, Jiangtao Jin, Deying Wang, Xiangliang Yuan, Qin Li
    Frontiers in Immunology.2022;[Epub]     CrossRef
  • Tumor vessel normalization and immunotherapy in gastric cancer
    Xianzhe Yu, Shan He, Jian Shen, Qiushi Huang, Peng Yang, Lin Huang, Dan Pu, Li Wang, Lu Li, Jinghua Liu, Zelong Liu, Lingling Zhu
    Therapeutic Advances in Medical Oncology.2022; 14: 175883592211101.     CrossRef
  • FN1 is a prognostic biomarker and correlated with immune infiltrates in gastric cancers
    Han Wang, Junchang Zhang, Huan Li, Hong Yu, Songyao Chen, Shuhao Liu, Changhua Zhang, Yulong He
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Molecular Pathology of Gastric Cancer
    Moonsik Kim, An Na Seo
    Journal of Gastric Cancer.2022; 22(4): 264.     CrossRef
  • Bioinformatics Analysis and Structure of Gastric Cancer Prognosis Model Based on Lipid Metabolism and Immune Microenvironment
    Yongzhi Chen, Hongjun Yuan, Qian Yu, Jianyu Pang, Miaomiao Sheng, Wenru Tang
    Genes.2022; 13(9): 1581.     CrossRef
  • Clinical implications of interleukins-31, 32, and 33 in gastric cancer
    Qing-Hua Liu, Ji-Wei Zhang, Lei Xia, Steven G Wise, Brett David Hambly, Kun Tao, Shi-San Bao
    World Journal of Gastrointestinal Oncology.2022; 14(9): 1808.     CrossRef
  • Microbiota and the Immune System—Actors in the Gastric Cancer Story
    Marek Majewski, Paulina Mertowska, Sebastian Mertowski, Konrad Smolak, Ewelina Grywalska, Kamil Torres
    Cancers.2022; 14(15): 3832.     CrossRef
  • Bioinformatics and Experimental Analyses Reveal MAP4K4 as a Potential Marker for Gastric Cancer
    Junping Zhang, Xiaoping Cai, Weifeng Cui, Zheng Wei
    Genes.2022; 13(10): 1786.     CrossRef
  • Common strategies for effective immunotherapy of gastroesophageal cancers using immune checkpoint inhibitors
    Shuang Ma, Fei Chen
    Pathology - Research and Practice.2022; 238: 154110.     CrossRef
  • High-level of intratumoral GITR+ CD4 T cells associate with poor prognosis in gastric cancer
    Shouyu Ke, Feng Xie, Yixian Guo, Jieqiong Chen, Zeyu Wang, Yimeng Yu, Haigang Geng, Danhua Xu, Xu Liu, Xiang Xia, Fengrong Yu, Chunchao Zhu, Zizhen Zhang, Gang Zhao, Bin Li, Wenyi Zhao
    iScience.2022; 25(12): 105529.     CrossRef
  • Characteristics of Adenosine-to-Inosine RNA editing-based subtypes and novel risk score for the prognosis and drug sensitivity in stomach adenocarcinoma
    Jingjing Pan, Xinyuan Gu, Jing Luo, Xinye Qian, Qiang Gao, Tianjie Li, Longying Ye, Chenlu Li
    Frontiers in Cell and Developmental Biology.2022;[Epub]     CrossRef
  • Inhibition of NF‐κB is required for oleanolic acid to downregulate PD‐L1 by promoting DNA demethylation in gastric cancer cells
    Xirong Lu, Yuyi Li, Wei Yang, Minghao Tao, Yanmiao Dai, Jinkang Xu, Qianfei Xu
    Journal of Biochemical and Molecular Toxicology.2021;[Epub]     CrossRef
  • Prognostic Value of C-Reactive Protein to Albumin Ratio in Gastric Cancer: A Meta-Analysis
    Liang Yue, Yi Lu, Yulin Li, Yilin Wang
    Nutrition and Cancer.2021; 73(10): 1864.     CrossRef
  • Immunogenic characteristics of microsatellite instability‐low esophagogastric junction adenocarcinoma based on clinicopathological, molecular, immunological and survival analyses
    Yu Imamura, Tasuku Toihata, Ikumi Haraguchi, Yoko Ogata, Manabu Takamatsu, Aya Kuchiba, Norio Tanaka, Osamu Gotoh, Seiichi Mori, Yuichiro Nakashima, Eiji Oki, Masaki Mori, Yoshinao Oda, Kenichi Taguchi, Manabu Yamamoto, Masaru Morita, Naoya Yoshida, Hideo
    International Journal of Cancer.2021; 148(5): 1260.     CrossRef
  • Two Similar Signatures for Predicting the Prognosis and Immunotherapy Efficacy of Stomach Adenocarcinoma Patients
    Taohua Yue, Shuai Zuo, Jing Zhu, Shihao Guo, Zhihao Huang, Jichang Li, Xin Wang, Yucun Liu, Shanwen Chen, Pengyuan Wang
    Frontiers in Cell and Developmental Biology.2021;[Epub]     CrossRef
  • Tumor microenvironment characterization in stage IV gastric cancer
    Feng Yang, Zhenbao Wang, Xianxue Zhang
    Bioscience Reports.2021;[Epub]     CrossRef
  • E2F2 inhibition induces autophagy via the PI3K/Akt/mTOR pathway in gastric cancer
    Hui Li, Shufen Zhao, Liwei Shen, Peige Wang, Shihai Liu, Yingji Ma, Zhiwei Liang, Gongjun Wang, Jing Lv, Wensheng Qiu
    Aging.2021; 13(10): 13626.     CrossRef
  • Chemoradiation induces upregulation of immunogenic cell death-related molecules together with increased expression of PD-L1 and galectin-9 in gastric cancer
    S. H. Petersen, L. F. Kua, S. Nakajima, W. P. Yong, K. Kono
    Scientific Reports.2021;[Epub]     CrossRef
  • Establishment of an Immune Cell Infiltration Score to Help Predict the Prognosis and Chemotherapy Responsiveness of Gastric Cancer Patients
    Quan Jiang, Jie Sun, Hao Chen, Chen Ding, Zhaoqing Tang, Yuanyuan Ruan, Fenglin Liu, Yihong Sun
    Frontiers in Oncology.2021;[Epub]     CrossRef
  • Microsatellite instability in Gastric Cancer: Between lights and shadows
    Elisabetta Puliga, Simona Corso, Filippo Pietrantonio, Silvia Giordano
    Cancer Treatment Reviews.2021; 95: 102175.     CrossRef
  • Survival-associated alternative splicing events interact with the immune microenvironment in stomach adenocarcinoma
    Zai-Sheng Ye, Miao Zheng, Qin-Ying Liu, Yi Zeng, Sheng-Hong Wei, Yi Wang, Zhi-Tao Lin, Chen Shu, Qiu-Hong Zheng, Lu-Chuan Chen
    World Journal of Gastroenterology.2021; 27(21): 2871.     CrossRef
  • Immunotherapy of gastric cancer: Past, future perspective and challenges
    Jun Xie, Liping Fu, Li Jin
    Pathology - Research and Practice.2021; 218: 153322.     CrossRef
  • Clinicopathologic and Prognostic Association of GRP94 Expression in Colorectal Cancer with Synchronous and Metachronous Metastases
    Sumi Yun, Sukmook Lee, Ho-Young Lee, Hyeon Jeong Oh, Yoonjin Kwak, Hye Seung Lee
    International Journal of Molecular Sciences.2021; 22(13): 7042.     CrossRef
  • Injectable shear-thinning polylysine hydrogels for localized immunotherapy of gastric cancer through repolarization of tumor-associated macrophages
    Yan Yang, Yang Yang, Meili Chen, Jianquan Chen, Jinyan Wang, Yajun Ma, Hanqing Qian
    Biomaterials Science.2021; 9(19): 6597.     CrossRef
  • Correlation between LRP1B Mutations and Tumor Mutation Burden in Gastric Cancer
    Sizhe Hu, Xiaokang Zhao, Feng Qian, Cancan Jin, Kaishun Hou, Tao Huang
    Computational and Mathematical Methods in Medicine.2021; 2021: 1.     CrossRef
  • Comprehensive Analysis to Identify MAGEA3 Expression Correlated With Immune Infiltrates and Lymph Node Metastasis in Gastric Cancer
    Jinji Jin, Jianxin Tu, Jiahuan Ren, Yiqi Cai, Wenjing Chen, Lifang Zhang, Qiyu Zhang, Guanbao Zhu
    Frontiers in Oncology.2021;[Epub]     CrossRef
  • Effect of P2X7 receptor on tumorigenesis and its pharmacological properties
    Wen-jun Zhang, Ce-gui Hu, Zheng-ming Zhu, Hong-liang Luo
    Biomedicine & Pharmacotherapy.2020; 125: 109844.     CrossRef
  • Current status and future potential of predictive biomarkers for immune checkpoint inhibitors in gastric cancer
    Byung Woog Kang, Ian Chau
    ESMO Open.2020; 5(4): e000791.     CrossRef
  • Is ramucirumab still the only second-line treatment in metastatic gastric cancer?
    Khalil El Gharib, Hampig Raphael Kourie
    Pharmacogenomics.2020; 21(17): 1203.     CrossRef
  • Deep Learning Predicts Underlying Features on Pathology Images with Therapeutic Relevance for Breast and Gastric Cancer
    Renan Valieris, Lucas Amaro, Cynthia Aparecida Bueno de Toledo Osório, Adriana Passos Bueno, Rafael Andres Rosales Mitrowsky, Dirce Maria Carraro, Diana Noronha Nunes, Emmanuel Dias-Neto, Israel Tojal da Silva
    Cancers.2020; 12(12): 3687.     CrossRef

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